Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RPS6KA5	9252	broad.mit.edu	37	14	91389482	91389482	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr14:91389482C>G	ENST00000261991.3	-	6	850	c.677G>C	c.(676-678)aGa>aCa	p.R226T	RPS6KA5_ENST00000418736.2_Missense_Mutation_p.R226T|RPS6KA5_ENST00000536315.2_Missense_Mutation_p.R147T	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	226	Protein kinase 1.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.R226T(2)		endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		ATCTCCCCCTCTGACAATATC	0.333000													5	106					0	0	0.029380	0	0
ASCC2	84164	broad.mit.edu	37	22	30197042	30197042	+	Silent	SNP	A	A	G			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr22:30197042A>G	ENST00000397771.2	-	16	1803	c.1626T>C	c.(1624-1626)aaT>aaC	p.N542N	ASCC2_ENST00000307790.3_Silent_p.N542N|ASCC2_ENST00000542393.1_Silent_p.N466N			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	542					regulation of transcription, DNA-dependent|transcription, DNA-dependent			p.N542N(1)		endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			CAAACTCGTCATTCTGGAAGA	0.567000													26	145					0	0	0.045705	0	0
MYH9	4627	broad.mit.edu	37	22	36708237	36708237	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr22:36708237C>A	ENST00000216181.5	-	14	1815	c.1585G>T	c.(1585-1587)Gac>Tac	p.D529Y		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	529	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity	p.D529Y(1)		NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						CACTCCTCGTCCAGCAGGGCC	0.637000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				8	73					1.58986e-06	1.70183e-06	0.069234	1	0
LRRTM4	80059	broad.mit.edu	37	2	77745685	77745685	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr2:77745685G>A	ENST00000409088.3	-	3	1724	c.1310C>T	c.(1309-1311)gCc>gTc	p.A437V	LRRTM4_ENST00000409282.1_Missense_Mutation_p.A438V|LRRTM4_ENST00000409093.1_Missense_Mutation_p.A437V|LRRTM4_ENST00000409884.1_Missense_Mutation_p.A437V|LRRTM4_ENST00000409911.1_Missense_Mutation_p.A438V	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	437						integral to membrane		p.A437V(2)		autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		GAGGATCATGGCCACTGAGAG	0.498000													20	71					0	0	0.062417	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	43					0	0	0.004672	0	0
CD4	920	broad.mit.edu	37	12	6925422	6925422	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr12:6925422C>T	ENST00000011653.4	+	6	1066	c.808C>T	c.(808-810)Cct>Tct	p.P270S	CD4_ENST00000538827.1_3'UTR|CD4_ENST00000541982.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	270	Ig-like C2-type 2.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding	p.P270S(1)		breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				TACCCAGGACCCTAAGCTCCA	0.587000													48	84					0	0	0.048971	0	0
SEMA3D	223117	broad.mit.edu	37	7	84644482	84644482	+	Silent	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr7:84644482G>A	ENST00000284136.6	-	14	1639	c.1596C>T	c.(1594-1596)caC>caT	p.H532H	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	532					cell differentiation|nervous system development	extracellular region|membrane	receptor activity	p.H532H(1)		NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TGTCGCATCTGTGCAAGGAGA	0.468000													11	65					0	0	0.080935	0	0
LAMA1	284217	broad.mit.edu	37	18	6980611	6980611	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr18:6980611C>G	ENST00000389658.3	-	42	6009	c.5916G>C	c.(5914-5916)ttG>ttC	p.L1972F		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1972	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding	p.L1972F(1)		NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTTATTTCTCAATTCACTCA	0.358000													4	55					0	0	0.009096	0	0
SLC2A8	29988	broad.mit.edu	37	9	130162258	130162258	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr9:130162258G>A	ENST00000373371.3	+	4	588	c.499G>A	c.(499-501)Gtc>Atc	p.V167I	SLC2A8_ENST00000373352.1_5'UTR|SLC2A8_ENST00000373360.3_Missense_Mutation_p.V167I	NM_001271712.1|NM_014580.3	NP_001258641.1|NP_055395.2	Q9NY64	GTR8_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 8	167						cytoplasmic vesicle membrane|integral to plasma membrane	D-glucose transmembrane transporter activity	p.V167I(1)		cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)	11						AATGGTCGTCGTCGGCATCCT	0.517000													12	68					0	0	0.105934	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													3	43					0	0	0.009096	0	0
ACTR3B	57180	broad.mit.edu	37	7	152497649	152497649	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr7:152497649A>C	ENST00000256001.8	+	3	268	c.134A>C	c.(133-135)gAc>gCc	p.D45A	ACTR3B_ENST00000537264.1_Intron|ACTR3B_ENST00000397282.2_5'UTR|ACTR3B_ENST00000377776.3_Missense_Mutation_p.D45A	NM_020445.5	NP_065178.1	Q9P1U1	ARP3B_HUMAN	ARP3 actin-related protein 3 homolog B (yeast)	45					regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding	p.D45A(1)		breast(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	13		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)		AAGGTAGTTGACCAAGCTCAA	0.373000													17	137					0	0	0.033300	0	0
LASP1	3927	broad.mit.edu	37	17	37034383	37034383	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr17:37034383A>G	ENST00000433206.2	+	2	273	c.31A>G	c.(31-33)Act>Gct	p.T11A	LASP1_ENST00000435347.3_Silent_p.T38T|LASP1_ENST00000318008.6_Silent_p.T38T			Q14847	LASP1_HUMAN	LIM and SH3 protein 1	0	LIM zinc-binding.					cortical actin cytoskeleton	ion transmembrane transporter activity|SH3/SH2 adaptor activity|zinc ion binding	p.T38T(1)		breast(1)|large_intestine(2)|lung(4)|urinary_tract(2)	9						GCAAGATGACACTGAACATGA	0.547000			T	MLL	AML								20	87					0	0	0.069288	0	0
STX8	9482	broad.mit.edu	37	17	9460847	9460847	+	Splice_Site	SNP	T	T	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr17:9460847T>A	ENST00000306357.3	-	3	545		c.e3-2		STX8_ENST00000573373.1_Splice_Site|STX8_ENST00000574431.1_Splice_Site	NM_004853.2	NP_004844.1	Q9UNK0	STX8_HUMAN	syntaxin 8						transport	endoplasmic reticulum|integral to plasma membrane		p.?(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|skin(1)|urinary_tract(1)	12						CACGGTAAGCTGAAAAGAAAA	0.403000													19	65					0	0	0.069288	0	0
SULT1B1	27284	broad.mit.edu	37	4	70620398	70620398	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr4:70620398T>A	ENST00000310613.2	-	3	564	c.267A>T	c.(265-267)ttA>ttT	p.L89F		NM_014465.3	NP_055280.2	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member 1	89					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol		p.L89F(1)		breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(14)|prostate(1)|upper_aerodigestive_tract(1)	24						CTGATGTTCTTAATCCAGGGA	0.308000													5	85					0	0	0.029380	0	0
MYH1	4619	broad.mit.edu	37	17	10412921	10412921	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr17:10412921G>A	ENST00000226207.5	-	15	1562	c.1468C>T	c.(1468-1470)Cag>Tag	p.Q490*	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	490	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity	p.Q490*(1)		NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TTGAAAAACTGTTGCAGTTTC	0.428000													23	178					0	0	0.034045	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755505	140755505	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr5:140755505G>A	ENST00000517434.1	+	1	1855	c.1855G>A	c.(1855-1857)Gtg>Atg	p.V619M	PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1												p.V619M(1)		breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTTTTCTCAGTGGGCCTGCA	0.682000													12	83					0	0	0.028581	0	0
IMPG1	3617	broad.mit.edu	37	6	76728564	76728564	+	Silent	SNP	T	T	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr6:76728564T>A	ENST00000369950.3	-	7	867	c.678A>T	c.(676-678)acA>acT	p.T226T	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	226					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity	p.T226T(1)		breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CAGCGAATTCTGTTTCTCTTT	0.403000													42	54					0	0	0.111260	0	0
GRID1	2894	broad.mit.edu	37	10	87898745	87898745	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr10:87898745G>A	ENST00000327946.7	-	4	642	c.557C>T	c.(556-558)tCg>tTg	p.S186L		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	186						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity	p.S186L(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	GCCCAGCCGCGAGGCCTGGTC	0.512000										Multiple Myeloma(13;0.14)			7	208					0	0	0.080935	0	0
PMFBP1	83449	broad.mit.edu	37	16	72174328	72174328	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr16:72174328C>T	ENST00000537465.1	-	6	948	c.790G>A	c.(790-792)Gcc>Acc	p.A264T	PMFBP1_ENST00000355636.6_Missense_Mutation_p.A119T|PMFBP1_ENST00000237353.10_Missense_Mutation_p.A264T			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	264								p.A264T(1)		NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TTACTGCAGGCCAGCTTATTT	0.463000													57	482					0	0	0.048971	0	0
NLRP5	126206	broad.mit.edu	37	19	56572884	56572884	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr19:56572884G>A	ENST00000390649.3	+	15	3593	c.3593G>A	c.(3592-3594)tGg>tAg	p.W1198*		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1198						mitochondrion|nucleolus	ATP binding	p.W1198*(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CGGTACTGGTGGAAAAACTGA	0.488000													20	72					0	0	0.076483	0	0
LINC00969	440993	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													3	36					0	0	0.009096	0	0
IFNLR1	163702	broad.mit.edu	37	1	24484026	24484026	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr1:24484026G>A	ENST00000327535.1	-	7	1169	c.1157C>T	c.(1156-1158)tCa>tTa	p.S386L	IFNLR1_ENST00000327575.2_3'UTR|IFNLR1_ENST00000374421.3_Missense_Mutation_p.S357L	NM_170743.3|NM_173064.2	NP_734464.1|NP_775087.1			interferon, lambda receptor 1									p.S386L(1)									GCTTCTGTCTGAAGAATCCCA	0.657000													3	39					0	0	0.009096	0	0
PARP9	83666	broad.mit.edu	37	3	122274901	122274901	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr3:122274901T>A	ENST00000462315.1	-	4	410	c.117A>T	c.(115-117)ttA>ttT	p.L39F	PARP9_ENST00000471785.1_Missense_Mutation_p.L39F|PARP9_ENST00000360356.2_Missense_Mutation_p.L74F|PARP9_ENST00000492382.1_Intron|PARP9_ENST00000477522.2_Missense_Mutation_p.L39F	NM_001146106.1	NP_001139578.1	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	74					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding	p.L74F(1)		endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	34				GBM - Glioblastoma multiforme(114;0.0519)		CATTATTTTTTAAAATTTTGA	0.383000													7	81					0	0	0.038147	0	0
RPAIN	84268	broad.mit.edu	37	17	5324728	5324728	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr17:5324728T>A	ENST00000381209.3	+	2	764	c.194T>A	c.(193-195)aTg>aAg	p.M65K	RPAIN_ENST00000536255.2_Missense_Mutation_p.M65K|RPAIN_ENST00000574003.1_Missense_Mutation_p.M65K|RPAIN_ENST00000405578.4_Missense_Mutation_p.M65K|RPAIN_ENST00000381208.5_Missense_Mutation_p.M65K|RPAIN_ENST00000327154.6_Missense_Mutation_p.M65K	NM_001033002.3	NP_001028174.2	Q86UA6	RIP_HUMAN	RPA interacting protein	65					DNA recombination|DNA repair|DNA-dependent DNA replication|protein import into nucleus|response to UV	cytoplasm|nucleolus|PML body	metal ion binding|protein complex binding	p.M65K(2)		breast(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)	6						CAAGAGGTGATGGAAGAAGAG	0.527000													10	97					0	0	0.069234	0	0
NFAT5	10725	broad.mit.edu	37	16	69724870	69724870	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr16:69724870A>G	ENST00000349945.1	+	13	3072	c.1520A>G	c.(1519-1521)gAt>gGt	p.D507G	NFAT5_ENST00000567239.1_Missense_Mutation_p.D600G|NFAT5_ENST00000566899.1_Missense_Mutation_p.D507G|NFAT5_ENST00000432919.1_Missense_Mutation_p.D601G|NFAT5_ENST00000354436.2_Missense_Mutation_p.D583G|NFAT5_ENST00000393742.2_Missense_Mutation_p.D507G	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	583					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.D507G(1)|p.D601G(1)		NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						TGTAATTTAGATAAGGTAAAT	0.313000													33	144					0	0	0.080422	0	0
PDPR	55066	broad.mit.edu	37	16	70165265	70165265	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr16:70165265G>A	ENST00000288050.4	+	8	1747	c.790G>A	c.(790-792)Gaa>Aaa	p.E264K	PDPR_ENST00000398122.3_Missense_Mutation_p.E164K|PDPR_ENST00000568530.1_Missense_Mutation_p.E264K	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	264					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity	p.E264K(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		ACATGCCTGCGAACACTTCTA	0.517000													3	14					0	0	0.004672	0	0
NF2	4771	broad.mit.edu	37	22	30035169	30035169	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr22:30035169C>T	ENST00000338641.4	+	3	772	c.331C>T	c.(331-333)Cag>Tag	p.Q111*	NF2_ENST00000397789.3_Nonsense_Mutation_p.Q111*|NF2_ENST00000413209.2_Nonsense_Mutation_p.Q111*|NF2_ENST00000361452.4_Intron|NF2_ENST00000361676.4_Nonsense_Mutation_p.Q69*|NF2_ENST00000347330.5_Intron|NF2_ENST00000403435.1_Nonsense_Mutation_p.Q111*|NF2_ENST00000403999.3_Nonsense_Mutation_p.Q111*|NF2_ENST00000361166.4_Nonsense_Mutation_p.Q111*|NF2_ENST00000353887.4_Intron|NF2_ENST00000334961.7_Intron	NM_000268.3|NM_016418.5|NM_181832.2	NP_000259.1|NP_057502.2|NP_861970.1	P35240	MERL_HUMAN	neurofibromin 2 (merlin)	111	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.Q111*(4)|p.?(3)|p.H95fs*3(1)|p.V86_Q111>E(1)|p.L97fs*17(1)		NS(1)|bone(2)|breast(5)|central_nervous_system(21)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(17)|large_intestine(9)|liver(1)|lung(9)|meninges(372)|ovary(2)|pituitary(1)|pleura(9)|prostate(1)|skin(7)|soft_tissue(303)|stomach(2)|thyroid(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	776						GGAGCTGGTTCAGGAGATCAC	0.458000			"""D, Mis, N, F, S, O"""		"""meningioma, acoustic neuroma, renal """	"""meningioma, acoustic neuroma"""			Neurofibromatosis, type 2				7	114					0	0	0.029380	0	0
FOXF2	2295	broad.mit.edu	37	6	1390684	1390684	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr6:1390684C>A	ENST00000259806.1	+	1	616	c.502C>A	c.(502-504)Ccc>Acc	p.P168T		NM_001452.1	NP_001443.1	Q12947	FOXF2_HUMAN	forkhead box F2	168					epithelial to mesenchymal transition|genitalia development|palate development|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding	p.P168T(1)		large_intestine(2)|lung(5)|prostate(1)	8	Ovarian(93;0.0733)	all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.095)		CCTCGGGCGGCCCGGCAAGGG	0.672000													5	89					1.23904e-05	1.30788e-05	0.014758	1	0
PCDH9	5101	broad.mit.edu	37	13	67801491	67801491	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr13:67801491C>T	ENST00000544246.1	-	2	1773	c.1082G>A	c.(1081-1083)aGg>aAg	p.R361K	PCDH9_ENST00000456367.1_Missense_Mutation_p.R361K|PCDH9_ENST00000377861.3_Missense_Mutation_p.R361K|PCDH9_ENST00000377865.2_Missense_Mutation_p.R361K|PCDH9_ENST00000328454.5_Missense_Mutation_p.R361K	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	361					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R361K(1)		breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TATAATGTACCTGAGGTCTAT	0.438000													9	265					0	0	0.058154	0	0
PARP14	54625	broad.mit.edu	37	3	122418783	122418783	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr3:122418783A>G	ENST00000474629.2	+	6	1648	c.1382A>G	c.(1381-1383)aAa>aGa	p.K461R		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	461					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity	p.K461R(1)|p.K298R(1)		NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		CAAAAAATTAAAAGGGAAGAG	0.398000													13	60					0	0	0.024245	0	0
FGF16	8823	broad.mit.edu	37	X	76711920	76711920	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chrX:76711920T>C	ENST00000439435.1	+	2	257	c.257T>C	c.(256-258)cTa>cCa	p.L86P				O43320	FGF16_HUMAN	fibroblast growth factor 16	0					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|metabolic process|organ morphogenesis|response to temperature stimulus	extracellular space	growth factor activity	p.T85T(1)		NS(1)|breast(1)|lung(2)	4						GATACAGGACTAAACGACACC	0.473000													16	93					0	0	0.033300	0	0
ERBB3	2065	broad.mit.edu	37	12	56489568	56489568	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr12:56489568G>A	ENST00000267101.3	+	17	2473	c.2033G>A	c.(2032-2034)aGg>aAg	p.R678K	ERBB3_ENST00000450146.2_Missense_Mutation_p.R35K|ERBB3_ENST00000415288.2_Missense_Mutation_p.R619K	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	678					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.R678K(1)		central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AGGGCTATGAGGCGATACTTG	0.433000													16	130					0	0	0.028581	0	0
UNC13A	23025	broad.mit.edu	37	19	17780382	17780382	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr19:17780382G>A	ENST00000428389.2	-	6	637	c.638C>T	c.(637-639)aCg>aTg	p.T213M	UNC13A_ENST00000252773.7_Missense_Mutation_p.T125M|UNC13A_ENST00000552293.1_Missense_Mutation_p.T125M|UNC13A_ENST00000550896.1_Missense_Mutation_p.T125M|UNC13A_ENST00000519716.2_Missense_Mutation_p.T125M|UNC13A_ENST00000551649.1_Missense_Mutation_p.T125M			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	125					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding	p.T213M(2)|p.T125M(2)		breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CTCAAAGCGCGTGTCCAGGAG	0.612000													8	32					0	0	0.058154	0	0
ABCC11	85320	broad.mit.edu	37	16	48244898	48244898	+	Silent	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr16:48244898C>T	ENST00000394747.1	-	10	1918	c.1569G>A	c.(1567-1569)ctG>ctA	p.L523L	ABCC11_ENST00000394748.1_Silent_p.L523L|ABCC11_ENST00000356608.2_Silent_p.L523L|ABCC11_ENST00000537808.1_Silent_p.L523L|ABCC11_ENST00000353782.5_Silent_p.L523L	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	523	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.L523L(1)		breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				ACTCTGGGCCCAGGCTGTTCC	0.617000													25	42					0	0	0.083992	0	0
NLRP5	126206	broad.mit.edu	37	19	56572808	56572808	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr19:56572808G>A	ENST00000390649.3	+	15	3517	c.3517G>A	c.(3517-3519)Gaa>Aaa	p.E1173K		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1173						mitochondrion|nucleolus	ATP binding	p.E1173K(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GCTGCTGGAGGAAGTGCAGCT	0.498000													17	55					0	0	0.038395	0	0
SNX30	401548	broad.mit.edu	37	9	115580031	115580031	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr9:115580031G>T	ENST00000374232.3	+	3	559	c.395G>T	c.(394-396)aGa>aTa	p.R132I		NM_001012994.1	NP_001013012.1	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	132	PX.				cell communication|protein transport	cytoplasm	phosphatidylinositol binding	p.R132I(1)		large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						GTTCGTCGAAGATACCAGGAT	0.438000													27	80					2.47511e-08	2.68726e-08	0.037714	1	0
SLC22A2	6582	broad.mit.edu	37	6	160679700	160679700	+	Silent	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr6:160679700C>T	ENST00000366952.1	-	3	1508	c.27G>A	c.(25-27)tcG>tcA	p.S9S	SLC22A2_ENST00000491092.1_5'UTR|SLC22A2_ENST00000366953.3_Silent_p.S30S			O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	30					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity	p.S30S(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CGAAGGTAGCCGAGAGCAGAG	0.612000													4	59					0	0	0.021553	0	0
DUSP9	1852	broad.mit.edu	37	X	152915088	152915088	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chrX:152915088G>A	ENST00000342782.3	+	3	1040	c.775G>A	c.(775-777)Gac>Aac	p.D259N	DUSP9_ENST00000370167.4_Missense_Mutation_p.D259N			Q99956	DUS9_HUMAN	dual specificity phosphatase 9	259	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity	p.D259N(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCCATCTCCGACCACTGGAG	0.567000													8	243					0	0	0.047766	0	0
ZNF770	54989	broad.mit.edu	37	15	35274487	35274487	+	Silent	SNP	T	T	C			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr15:35274487T>C	ENST00000356321.4	-	3	1493	c.1149A>G	c.(1147-1149)agA>agG	p.R383R		NM_014106.3	NP_054825.2	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	383					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R383R(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)	29		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		CCACAAATGTTCTCTGGGTTT	0.328000													6	78					0	0	0.038147	0	0
SLC22A3	6581	broad.mit.edu	37	6	160831831	160831831	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr6:160831831C>T	ENST00000392145.1	+	5	955	c.928C>T	c.(928-930)Cgc>Tgc	p.R310C	SLC22A3_ENST00000275300.2_Missense_Mutation_p.R310C			O75751	S22A3_HUMAN	solute carrier family 22 (organic cation transporter), member 3	310						integral to plasma membrane|membrane fraction	protein binding|quaternary ammonium group transmembrane transporter activity	p.R310C(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		Breast(66;0.00028)|Ovarian(120;0.0308)|Prostate(117;0.218)		OV - Ovarian serous cystadenocarcinoma(65;9.47e-17)|BRCA - Breast invasive adenocarcinoma(81;9.75e-06)		GATCCTGAGACGCATTGCTAA	0.418000													9	89					0	0	0.047766	0	0
NFX1	4799	broad.mit.edu	37	9	33369972	33369972	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr9:33369972A>G	ENST00000379540.3	+	24	3421	c.3359A>G	c.(3358-3360)gAc>gGc	p.D1120G		NM_002504.4	NP_002495.2	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	1120					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.D1120G(1)		central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		GACGTCCAGGACTAAGAAGAT	0.388000													3	52					0	0	0.004672	0	0
C10orf137	26098	broad.mit.edu	37	10	127429728	127429728	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr10:127429728C>T	ENST00000337623.3	+	16	2332	c.2227C>T	c.(2227-2229)Cag>Tag	p.Q743*	C10orf137_ENST00000356792.4_Nonsense_Mutation_p.Q777*	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	777					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding	p.Q743*(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AAAAGAAGACCAGGAGATCCT	0.473000													16	111					0	0	0.024245	0	0
SLC22A6	9356	broad.mit.edu	37	11	62752036	62752036	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr11:62752036C>T	ENST00000377871.3	-	1	393	c.127G>A	c.(127-129)Gcc>Acc	p.A43T	SLC22A6_ENST00000360421.4_Missense_Mutation_p.A43T|SLC22A6_ENST00000458333.2_Missense_Mutation_p.A43T|SLC22A6_ENST00000421062.2_Missense_Mutation_p.A43T	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	43					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding	p.A43T(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GTAGGGATGGCAGCAGTGAAG	0.672000													3	31					0	0	0.004672	0	0
CAD	790	broad.mit.edu	37	2	27462316	27462316	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr2:27462316G>A	ENST00000264705.4	+	33	5533	c.5371G>A	c.(5371-5373)Gag>Aag	p.E1791K	CAD_ENST00000403525.1_Missense_Mutation_p.E1728K	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1791	Linker.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity	p.E1791K(1)		NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	CCTGCGAGGGGAGGTTGCCTA	0.577000													3	34					0	0	0.009096	0	0
NVL	4931	broad.mit.edu	37	1	224477242	224477242	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr1:224477242G>A	ENST00000281701.6	-	13	1778	c.1519C>T	c.(1519-1521)Cca>Tca	p.P507S	NVL_ENST00000340871.4_Missense_Mutation_p.P318S|NVL_ENST00000469075.1_Missense_Mutation_p.P416S|NVL_ENST00000391875.2_Missense_Mutation_p.P401S|NVL_ENST00000482491.1_Missense_Mutation_p.P231S|NVL_ENST00000361463.3_Missense_Mutation_p.P401S	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	507						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity	p.P507S(2)		breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		CCTTTAGATGGCAAATCTTCC	0.443000													4	71					0	0	0.014758	0	0
BEND3	57673	broad.mit.edu	37	6	107390628	107390628	+	Silent	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr6:107390628C>T	ENST00000429433.2	-	5	2416	c.1767G>A	c.(1765-1767)gaG>gaA	p.E589E	BEND3_ENST00000369042.1_Silent_p.E589E	NM_001080450.2	NP_001073919.1	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	589	BEN 3.							p.E589E(1)		central_nervous_system(1)|cervix(2)|endometrium(3)|large_intestine(7)|lung(10)|ovary(4)|prostate(3)	30						TGCGCAGGTTCTCGTGCGTGA	0.627000													9	58					0	0	0.093190	0	0
SYNE1	23345	broad.mit.edu	37	6	152751686	152751686	+	Silent	SNP	T	T	C			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr6:152751686T>C	ENST00000367255.5	-	35	5221	c.4620A>G	c.(4618-4620)gcA>gcG	p.A1540A	SYNE1_ENST00000341594.5_Silent_p.A1610A|SYNE1_ENST00000448038.1_Silent_p.A1547A|SYNE1_ENST00000367253.4_Silent_p.A1540A|SYNE1_ENST00000423061.1_Silent_p.A1547A|SYNE1_ENST00000265368.4_Silent_p.A1540A	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1540					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.A1540A(2)|p.A1547A(1)		NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCAGACACTGTGCATGCTCTC	0.413000										HNSCC(10;0.0054)			14	380					0	0	0.024245	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	72					0	0	0.004672	0	0
FBXO43	286151	broad.mit.edu	37	8	101146122	101146122	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr8:101146122C>G	ENST00000428847.2	-	5	2351	c.2035G>C	c.(2035-2037)Gaa>Caa	p.E679Q		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	679					meiosis		zinc ion binding	p.E645Q(2)|p.E679Q(1)		endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			CTACATTCTTCAGACCCATGA	0.453000													93	117					0	0	0.048971	0	0
OXTR	5021	broad.mit.edu	37	3	8809556	8809556	+	Silent	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr3:8809556G>A	ENST00000316793.3	-	3	942	c.318C>T	c.(316-318)taC>taT	p.Y106Y	CAV3_ENST00000472766.1_Intron	NM_000916.3	NP_000907.2	P30559	OXYR_HUMAN	oxytocin receptor	106					female pregnancy|lactation|muscle contraction	integral to plasma membrane	oxytocin receptor activity|vasopressin receptor activity	p.Y106Y(1)		NS(1)|endometrium(2)|large_intestine(4)|lung(5)|urinary_tract(1)	13				OV - Ovarian serous cystadenocarcinoma(96;0.15)	Carbetocin(DB01282)	GGTCGGGCCCGTAGAAGCGGA	0.612000													3	15					0	0	0.004672	0	0
FBXO43	286151	broad.mit.edu	37	8	101154000	101154000	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr8:101154000G>C	ENST00000428847.2	-	2	798	c.482C>G	c.(481-483)tCt>tGt	p.S161C		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	161					meiosis		zinc ion binding	p.S127C(2)|p.S161C(1)		endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			AAGAGCGAAAGATACATTCAA	0.348000													17	282					0	0	0.038395	0	0
SLC5A1	6523	broad.mit.edu	37	22	32445957	32445957	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr22:32445957G>C	ENST00000266088.4	+	2	413	c.163G>C	c.(163-165)Gtt>Ctt	p.V55L		NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	55					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding	p.V55L(1)		NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						TCGTGGGACTGTTGGAGGCTT	0.468000													68	248					0	0	0.048971	0	0
ABCA7	10347	broad.mit.edu	37	19	1063563	1063563	+	Silent	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr19:1063563G>A	ENST00000263094.6	+	43	5964	c.5733G>A	c.(5731-5733)gcG>gcA	p.A1911A	ABCA7_ENST00000433129.1_Silent_p.A1911A|ABCA7_ENST00000435683.2_Silent_p.A1773A	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1911	ABC transporter 2.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity	p.A1911A(1)		NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGGCCTGGCGCGTCTGGGAC	0.667000													4	41					0	0	0.009096	0	0
ALDH1A3	220	broad.mit.edu	37	15	101433167	101433167	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr15:101433167T>A	ENST00000329841.5	+	5	1025	c.493T>A	c.(493-495)Ttc>Atc	p.F165I	ALDH1A3_ENST00000346623.6_Intron	NM_000693.2	NP_000684.2	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1 family, member A3	165					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity	p.F165I(1)		NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(7)|lung(9)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	27	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	CGTCGTGTGCTTCACCAGGCA	0.493000													29	86					0	0	0.045705	0	0
C3orf17	25871	broad.mit.edu	37	3	112727277	112727277	+	Splice_Site	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr3:112727277C>T	ENST00000314400.5	-	8	1167	c.975_splice	c.e8-1	p.E326_splice	C3orf17_ENST00000383675.2_Splice_Site_p.E256_splice|C3orf17_ENST00000393857.2_Splice_Site_p.E190_splice|C3orf17_ENST00000472762.1_5'UTR	NM_015412.3	NP_056227.2	Q6NW34	CC017_HUMAN	chromosome 3 open reading frame 17	326						integral to membrane		p.E326K(1)		central_nervous_system(1)|endometrium(1)|kidney(2)|lung(6)|prostate(2)|skin(1)	13						AAACTGGTCTCCTGAAACGTG	0.328000													22	107					0	0	0.083992	0	0
STAC3	246329	broad.mit.edu	37	12	57641974	57641974	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr12:57641974C>A	ENST00000332782.2	-	5	641	c.440G>T	c.(439-441)gGt>gTt	p.G147V	STAC3_ENST00000546246.2_5'UTR|STAC3_ENST00000554578.1_Missense_Mutation_p.G108V	NM_145064.1	NP_659501.1	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	147					intracellular signal transduction		identical protein binding|metal ion binding	p.G147V(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(2)|skin(1)	18						CCGATGGAAACCAGGTGGCTG	0.498000													44	97					1.00953e-15	1.11195e-15	0.045515	1	0
CD72	971	broad.mit.edu	37	9	35616193	35616193	+	Silent	SNP	G	G	C			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr9:35616193G>C	ENST00000396757.1	-	6	599	c.435C>G	c.(433-435)ctC>ctG	p.L145L	CD72_ENST00000490239.1_5'UTR|CD72_ENST00000378431.1_3'UTR|CD72_ENST00000259633.4_Silent_p.L145L			P21854	CD72_HUMAN	CD72 molecule	145					axon guidance|cell adhesion	integral to plasma membrane	receptor binding|sugar binding|transmembrane receptor activity	p.L145L(1)		large_intestine(5)|liver(1)|lung(6)	12			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCGTTATCTTGAGGCGGAGCT	0.577000													10	99					0	0	0.080935	0	0
CHN1	1123	broad.mit.edu	37	2	175742790	175742790	+	Silent	SNP	G	G	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr2:175742790G>A	ENST00000409900.3	-	6	640	c.327C>T	c.(325-327)cgC>cgT	p.R109R	CHN1_ENST00000409156.3_Silent_p.R109R|CHN1_ENST00000488080.1_Intron	NM_001822.5	NP_001813.1	P15882	CHIN_HUMAN	chimerin 1	109	SH2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity	p.R109R(1)		NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.226)			TGGACTCAAAGCGTTTCTCCC	0.418000			T	TAF15	extraskeletal myxoid chondrosarcoma								8	77					0	0	0.047766	0	0
CCDC116	164592	broad.mit.edu	37	22	21988400	21988400	+	Silent	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr22:21988400C>T	ENST00000292779.3	+	3	323	c.162C>T	c.(160-162)agC>agT	p.S54S		NM_152612.2	NP_689825.2	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	54								p.S54S(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(5)	22	Colorectal(54;0.105)					CATGTGGCAGCTCAGCACTCC	0.612000													11	69					0	0	0.020292	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554534	140554534	+	Silent	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr5:140554534C>T	ENST00000231137.3	+	1	2292	c.2118C>T	c.(2116-2118)ttC>ttT	p.F706F		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		706					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.F706F(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTCCTGTTCGTGGCGGTGC	0.692000													10	352					0	0	0.062417	0	0
TEX2	55852	broad.mit.edu	37	17	62230409	62230409	+	Silent	SNP	C	C	T			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr17:62230409C>T	ENST00000258991.3	-	10	3141	c.3057G>A	c.(3055-3057)aaG>aaA	p.K1019K	TEX2_ENST00000583097.1_Silent_p.K1012K|TEX2_ENST00000584379.1_Silent_p.K1012K|TEX2_ENST00000581812.1_5'UTR			Q8IWB9	TEX2_HUMAN	testis expressed 2	1012					signal transduction|sphingolipid metabolic process	integral to membrane		p.K1019K(1)		breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		CTTCTTCGATCTTCTTTTTAA	0.418000													10	76					0	0	0.058154	0	0
GCSHP3	100329109	broad.mit.edu	37	2	206981155	206981155	+	RNA	DEL	C	C	-	rs71410864		TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr2:206981155delC	ENST00000453039.1	+	0	885					NR_033248.1																						AGGCAGGGCGCGGCAGGTGCC	0.627													5	3	---	---	---	---					
ABHD14B	84836	broad.mit.edu	37	3	52003555	52003564	+	Frame_Shift_Del	DEL	GCTTCAGGTG	GCTTCAGGTG	-	rs148406733	byFrequency	TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr3:52003555_52003564delGCTTCAGGTG	ENST00000315877.10	-	6	1198_1207	c.505_514delCACCTGAAGC	c.(505-516)agfs	p.HLKQ169fs	ABHD14B_ENST00000525795.1_Frame_Shift_Del_p.HLKQ171fs|RP11-155D18.12_ENST00000488257.1_RNA|ABHD14B_ENST00000487005.1_5'UTR|ABHD14B_ENST00000483233.1_Frame_Shift_Del_p.HLKQ171fs|ABHD14B_ENST00000395008.2_Frame_Shift_Del_p.HLKQ171fs|ABHD14B_ENST00000361143.5_Frame_Shift_Del_p.HLKQ171fs|ABHD14B_ENST00000461108.1_3'UTR			Q96IU4	ABHEB_HUMAN	abhydrolase domain containing 14B	171						cytoplasm|nucleus	hydrolase activity			large_intestine(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000548)|KIRC - Kidney renal clear cell carcinoma(197;0.00072)		TTGGGCAGCTGCTTCAGGTGCTCAAAGCTG	0.595													7	204	---	---	---	---					
PRRC2A	7916	broad.mit.edu	37	6	31605327	31605328	+	Frame_Shift_Ins	INS	-	-	G			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr6:31605327_31605328insG	ENST00000376033.2	+	31	6672_6673	c.6438_6439insG	c.(6436-6441)cggggafs	p.RG2146fs	PRRC2A_ENST00000376007.4_Frame_Shift_Ins_p.RG2146fs	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	2146						cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CTGGGTCCCGAGGGGACAAGGA	0.634													10	77	---	---	---	---					
PHACTR2	9749	broad.mit.edu	37	6	144086413	144086414	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr6:144086413_144086414insA	ENST00000427704.2	+	6	807_808	c.677_678insA	c.(676-678)taafs	p.*226fs	PHACTR2_ENST00000305766.6_Frame_Shift_Ins_p.*146fs|PHACTR2_ENST00000367584.4_Frame_Shift_Ins_p.*214fs|PHACTR2_ENST00000367582.3_Frame_Shift_Ins_p.*157fs|PHACTR2_ENST00000440869.2_Frame_Shift_Ins_p.*237fs	NM_001100166.1|NM_014721.2	NP_001093636.1|NP_055536.2	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2	226							actin binding|protein phosphatase inhibitor activity			NS(3)|breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TCCTCTCATTCAAAAAAAACAA	0.396													7	246	---	---	---	---					
KMT2C	58508	broad.mit.edu	37	7	151896444	151896445	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr7:151896444_151896445delTT	ENST00000355193.2	-	27	4410_4411	c.4192_4193delAA	c.(4192-4194)cfs	p.N1398fs	KMT2C_ENST00000262189.6_Frame_Shift_Del_p.N1398fs					lysine (K)-specific methyltransferase 2C																		TGTGTTCATGTTTGTTTTATAT	0.371													8	37	---	---	---	---					
NCOA2	10499	broad.mit.edu	37	8	71126235	71126235	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr8:71126235delA	ENST00000452400.2	-	4	343	c.162delT	c.(160-162)ttfs	p.F54fs		NM_006540.2	NP_006531.1	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	54					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)|HEY1/NCOA2(10)	NS(1)|breast(4)|endometrium(7)|kidney(4)|large_intestine(10)|lung(25)|ovary(1)|pancreas(2)|prostate(2)|skin(4)	60	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			TAAAATTTGCAAAAATCAACT	0.303			T	"""RUNXBP2, HEY1"""	"""AML, Chondrosarcoma"""								8	32	---	---	---	---					
MAFA	389692	broad.mit.edu	37	8	144511954	144511956	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr8:144511954_144511956delTGG	ENST00000333480.2	-	1	620_622	c.621_623delCCA	c.(619-624)cat>ca	p.HH207del	MAFA_ENST00000528185.1_5'UTR	NM_201589.3	NP_963883.2	Q8NHW3	MAFA_HUMAN	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	207	His-rich.				insulin secretion|nitric oxide mediated signal transduction|response to glucose stimulus	nucleus	protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.H208delH(3)		breast(1)|lung(1)|upper_aerodigestive_tract(2)	4	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.237)			CGCGCCGCCAtggtggtggtggt	0.744										HNSCC(29;0.082)			2	4	---	---	---	---					
PPP1CA	5499	broad.mit.edu	37	11	67166623	67166623	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr11:67166623delC	ENST00000376745.4	-	5	683	c.535delG	c.(535-537)acfs	p.D179fs	PPP1CA_ENST00000312989.7_Frame_Shift_Del_p.D190fs|PPP1CA_ENST00000532446.1_5'UTR|PPP1CA_ENST00000358239.4_Frame_Shift_Del_p.D135fs	NM_001008709.1|NM_002708.3	NP_001008709.1|NP_002699.1	P62136	PP1A_HUMAN	protein phosphatase 1, catalytic subunit, alpha isozyme	179					cell cycle|cell division|glycogen metabolic process|protein dephosphorylation|triglyceride catabolic process	cytosol|MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein phosphatase type 1 regulator activity|protein serine/threonine phosphatase activity			breast(1)|lung(2)|pancreas(1)|urinary_tract(3)	7			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			GACTGCAGGTCCGGGGACAGG	0.622													10	62	---	---	---	---					
ERBB2	2064	broad.mit.edu	37	17	37880997	37880998	+	In_Frame_Ins	INS	-	-	TAT	rs144434331		TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chr17:37880997_37880998insTAT	ENST00000406381.2	+	22	2746_2747	c.2236_2237insTAT	c.(2236-2238)tgt>TATtgt	p.745_746insY	ERBB2_ENST00000584601.1_In_Frame_Ins_p.745_746insY|ERBB2_ENST00000269571.5_In_Frame_Ins_p.775_776insY|ERBB2_ENST00000584450.1_In_Frame_Ins_p.775_776insY|ERBB2_ENST00000541774.1_In_Frame_Ins_p.760_761insY|ERBB2_ENST00000445658.2_In_Frame_Ins_p.499_500insY|ERBB2_ENST00000540147.1_In_Frame_Ins_p.745_746insY	NM_001005862.1	NP_001005862.1	P04626	ERBB2_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	775	Protein kinase.				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.A775_G776insYVMA(10)|p.G776>VC(9)|p.G776>LC(3)|p.G776V(2)|p.G776S(2)|p.G776C(1)		NS(1)|breast(16)|central_nervous_system(17)|endometrium(6)|haematopoietic_and_lymphoid_tissue(8)|kidney(4)|large_intestine(16)|liver(3)|lung(125)|ovary(18)|pancreas(1)|prostate(4)|skin(1)|stomach(14)|upper_aerodigestive_tract(9)|urinary_tract(4)	247	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	CGTGATGGCTGGTGTGGGCTCC	0.579		1	"""A, Mis, O"""		"""breast, ovarian, other tumour types, NSCLC, gastric"""					TCGA GBM(5;<1E-08)			19	76	---	---	---	---					
KDM5C	8242	broad.mit.edu	37	X	53225159	53225159	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chrX:53225159delT	ENST00000452825.3	-	18	3390	c.2858delA	c.(2857-2859)cgfs	p.Q953fs	KDM5C_ENST00000404049.3_Frame_Shift_Del_p.Q1019fs|KDM5C_ENST00000375383.3_Frame_Shift_Del_p.Q979fs|KDM5C_ENST00000375379.3_Frame_Shift_Del_p.Q1020fs|KDM5C_ENST00000375401.3_Frame_Shift_Del_p.Q1020fs	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	1020					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						CTTGAGAGCCTGGATGTTGGG	0.542			"""N, F, S"""		clear cell renal carcinoma								13	28	---	---	---	---					
SLC6A14	11254	broad.mit.edu	37	X	115584241	115584241	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4434-01A-01D-1265-08	TCGA-05-4434-10A-01D-1265-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f529778c-5968-4d87-80c0-bd14ba2311d0	934b703f-5677-4597-9bf5-b55604e1f7d9	g.chrX:115584241delT	ENST00000371900.4	+	9	1307	c.1219delT	c.(1219-1221)ttfs	p.F407fs		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	407					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	AGGTGGTCCATTTTGGTCCAT	0.368													7	141	---	---	---	---