Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SMC2	10592	broad.mit.edu	37	9	106876287	106876287	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:106876287C>G	ENST00000286398.7	+	12	1745	c.1457C>G	c.(1456-1458)tCt>tGt	p.S486C	SMC2_ENST00000303219.8_Missense_Mutation_p.S486C|SMC2_ENST00000374787.3_Missense_Mutation_p.S486C|SMC2_ENST00000374793.3_Missense_Mutation_p.S486C	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	486					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						AGGCAGCTGTCTCGTGATATT	0.338000													9	109					0	0	0.047766	0	0
MYO10	4651	broad.mit.edu	37	5	16699587	16699587	+	Silent	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:16699587C>T	ENST00000513610.1	-	26	3982	c.3528G>A	c.(3526-3528)ccG>ccA	p.P1176P	MYO10_ENST00000505695.1_Silent_p.P515P|MYO10_ENST00000427430.2_Silent_p.P533P|MYO10_ENST00000274203.9_Silent_p.P533P|MYO10_ENST00000515803.1_Silent_p.P515P	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1176					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						TGTGGAAATACGGCAGAGTGA	0.488000													12	54					0	0	0.105934	0	0
FAT3	120114	broad.mit.edu	37	11	92534203	92534203	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:92534203C>T	ENST00000298047.6	+	9	8041	c.8024C>T	c.(8023-8025)tCg>tTg	p.S2675L	FAT3_ENST00000525166.1_Missense_Mutation_p.S2525L|FAT3_ENST00000409404.2_Missense_Mutation_p.S2675L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2675	Cadherin 24.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACAGTGCTTTCGTTCTTTGTC	0.483000										TCGA Ovarian(4;0.039)			3	27					0	0	0.115264	0	0
CTPS2	56474	broad.mit.edu	37	X	16717205	16717205	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:16717205C>T	ENST00000443824.1	-	3	921	c.178G>A	c.(178-180)Gtc>Atc	p.V60I	CTPS2_ENST00000380241.3_Missense_Mutation_p.V60I|CTPS2_ENST00000359276.4_Missense_Mutation_p.V60I	NM_001144002.1	NP_001137474.1	Q9NRF8	PYRG2_HUMAN	CTP synthase 2	60					glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Hepatocellular(33;0.0997)					TCATTTAAGACGAAGACTTCA	0.313000													19	76					0	0	0.055883	0	0
KBTBD6	89890	broad.mit.edu	37	13	41705374	41705374	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr13:41705374C>T	ENST00000379485.1	-	1	1508	c.1274G>A	c.(1273-1275)cGt>cAt	p.R425H	KBTBD6_ENST00000499385.2_Missense_Mutation_p.R359H	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	425							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		CATGCCCTCACGACACAGCAA	0.483000													19	118					0	0	0.175082	0	0
BFAR	51283	broad.mit.edu	37	16	14761536	14761536	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr16:14761536C>T	ENST00000261658.2	+	8	1482	c.1205C>T	c.(1204-1206)aCg>aTg	p.T402M	BFAR_ENST00000563082.1_3'UTR|BFAR_ENST00000426842.2_Missense_Mutation_p.T274M|BFAR_ENST00000563971.1_Missense_Mutation_p.T277M	NM_016561.2	NP_057645.1	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	402					anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	11						AAAGTATCAACGCAGGGGCTT	0.488000													14	47					0	0	0.132662	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581715	140581715	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:140581715C>T	ENST00000354757.3	+	1	2368	c.2368C>T	c.(2368-2370)Cga>Tga	p.R790*	PCDHB11_ENST00000536699.1_Nonsense_Mutation_p.R425*	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		790					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCACCTTTCGAAATAGCTT	0.323000													3	25					0	0	0.115264	0	0
SDHA	6389	broad.mit.edu	37	5	236581	236581	+	Silent	SNP	C	C	T	rs144473374		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:236581C>T	ENST00000264932.6	+	10	1414	c.1299C>T	c.(1297-1299)ccC>ccT	p.P433P	SDHA_ENST00000510361.1_Silent_p.P385P|SDHA_ENST00000504309.1_Silent_p.P433P	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	433					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	AGATTGTGCCCGGCCTGTACG	0.602000									Familial Paragangliomas				7	23					0	0	0.069234	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70712712	70712712	+	RNA	SNP	A	A	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr14:70712712A>T	ENST00000530196.1	-	0	1806					NR_003951.1																						AAGACATCAGAGATATGACAT	0.383000													13	71					0	0	0.055883	0	0
PTCHD1	139411	broad.mit.edu	37	X	23412133	23412133	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:23412133T>A	ENST00000379361.4	+	3	3358	c.2498T>A	c.(2497-2499)gTc>gAc	p.V833D		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	833					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						ATAGCATTTGTCACCTTCTTT	0.423000													5	71					0	0	0.014758	0	0
SLC6A2	6530	broad.mit.edu	37	16	55690765	55690765	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr16:55690765G>A	ENST00000379906.2	+	1	414	c.159G>A	c.(157-159)gcG>gcA	p.A53A	SLC6A2_ENST00000414754.3_Silent_p.A53A|SLC6A2_ENST00000219833.8_Silent_p.A53A|SLC6A2_ENST00000561820.1_Silent_p.A53A|SLC6A2_ENST00000568943.1_Silent_p.A53A|SLC6A2_ENST00000566163.1_Silent_p.A53A	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	53					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity	p.A53A(2)		breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	ACGGCGACGCGCAGCCCCGGG	0.682000													15	51					0	0	0.132662	0	0
MAST2	23139	broad.mit.edu	37	1	46497165	46497165	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:46497165C>T	ENST00000361297.2	+	24	3378	c.3095C>T	c.(3094-3096)tCt>tTt	p.S1032F	MAST2_ENST00000372008.1_Intron|MAST2_ENST00000372009.2_Missense_Mutation_p.S962F	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	1032					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CGGCTGCTCTCTGGGGACTCA	0.637000													6	15					0	0	0.047766	0	0
FREM1	158326	broad.mit.edu	37	9	14848754	14848754	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:14848754G>A	ENST00000380881.4	-	8	1988	c.1173C>T	c.(1171-1173)taC>taT	p.Y391Y	FREM1_ENST00000422223.2_Silent_p.Y390Y|FREM1_ENST00000380880.3_Silent_p.Y390Y			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	390					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGAAGAAGTCGTATACCTCCA	0.453000													21	37					0	0	0.062417	0	0
LOXL4	84171	broad.mit.edu	37	10	100013452	100013452	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr10:100013452G>A	ENST00000260702.3	-	11	1843	c.1693C>T	c.(1693-1695)Ctc>Ttc	p.L565F	RP11-34A14.3_ENST00000433374.1_RNA	NM_032211.6	NP_115587.6	Q96JB6	LOXL4_HUMAN	lysyl oxidase-like 4	565	Lysyl-oxidase like.					extracellular space|membrane	copper ion binding|protein binding|scavenger receptor activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(8)|ovary(4)|prostate(1)|skin(2)	26		Colorectal(252;0.234)		Epithelial(162;2.14e-11)|all cancers(201;2.49e-09)		GACTTGGAGAGGCAGTTCTCC	0.597000													5	29					0	0	0.014758	0	0
F13A1	2162	broad.mit.edu	37	6	6305708	6305708	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:6305708G>A	ENST00000264870.3	-	3	460	c.195C>T	c.(193-195)caC>caT	p.H65H		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	65					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TGTCAGTGTGGTGGTCCACCT	0.438000													15	38					0	0	0.132662	0	0
MMS22L	253714	broad.mit.edu	37	6	97634528	97634528	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:97634528T>C	ENST00000275053.4	-	15	2343	c.2078A>G	c.(2077-2079)gAc>gGc	p.D693G	MMS22L_ENST00000369251.2_Missense_Mutation_p.D653G	NM_198468.2	NP_940870.2	Q6ZRQ5	MMS22_HUMAN	MMS22-like, DNA repair protein	693					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding			breast(1)|endometrium(9)|kidney(2)|large_intestine(12)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	50						GTCCACATTGTCCCTTTGAAG	0.373000													13	49					0	0	0.105934	0	0
DLD	1738	broad.mit.edu	37	7	107557789	107557789	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:107557789G>A	ENST00000205402.5	+	11	1399	c.1118G>A	c.(1117-1119)tGt>tAt	p.C373Y	DLD_ENST00000440410.1_Missense_Mutation_p.C350Y|DLD_ENST00000537148.1_Missense_Mutation_p.C274Y|DLD_ENST00000437604.2_Missense_Mutation_p.C325Y	NM_000108.3	NP_000099.2	P09622	DLDH_HUMAN	dihydrolipoamide dehydrogenase	373					branched chain family amino acid catabolic process|cell redox homeostasis|lysine catabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|tricarboxylic acid cycle	mitochondrial matrix	dihydrolipoyl dehydrogenase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(10)|prostate(1)	20					NADH(DB00157)	GGCATTATCTGTGTTGAAGGA	0.443000													18	44					0	0	0.043863	0	0
DSP	1832	broad.mit.edu	37	6	7583731	7583731	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:7583731A>C	ENST00000379802.3	+	24	6577	c.6236A>C	c.(6235-6237)gAc>gCc	p.D2079A	DSP_ENST00000418664.2_Missense_Mutation_p.D1480A	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2079	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GACCTCATTGACTTCGATGAC	0.478000													12	116					0	0	0.093190	0	0
HEY1	23462	broad.mit.edu	37	8	80679298	80679298	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr8:80679298G>A	ENST00000337919.5	-	3	388	c.195C>T	c.(193-195)atC>atT	p.I65I	HEY1_ENST00000354724.3_Silent_p.I65I	NM_001040708.1	NP_001035798.1	Q9Y5J3	HEY1_HUMAN	hes-related family bHLH transcription factor with YRPW motif 1	65	Helix-loop-helix motif.|Transcriptional repression and interaction with NCOR1 and SIN3A (By similarity).				angiogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|transcription, DNA-dependent	nucleus	DNA binding|protein binding		HEY1/NCOA2(10)	cervix(1)|kidney(2)|large_intestine(5)|lung(14)	22	all_lung(9;5.1e-05)		Epithelial(68;0.076)|all cancers(69;0.179)			AACTGTTATTGATCCGGTCTC	0.438000			T	NCOA2	mesenchymal chondrosarcoma								7	109					0	0	0.038147	0	0
FBN1	2200	broad.mit.edu	37	15	48791196	48791196	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr15:48791196G>A	ENST00000316623.5	-	18	2608	c.2153C>T	c.(2152-2154)aCg>aTg	p.T718M		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	718					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCCTGCTGACGTCATTCCTGG	0.458000													26	76					0	0	0.144211	0	0
C4B	721	broad.mit.edu	37	6	31997026	31997026	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:31997026C>T	ENST00000435363.2	+	28	3671	c.3587C>T	c.(3586-3588)aCg>aTg	p.T1196M	C4B_ENST00000425700.2_Missense_Mutation_p.T1196M	NM_001002029.3	NP_001002029.3	P0C0L5	CO4B_HUMAN	complement component 4B (Chido blood group)	1196					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity										GCTGCCATCACGGCCTATGCC	0.607000													3	22					0	0	0.115264	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459813	66459813	+	RNA	SNP	G	G	A	rs10752517	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:66459813G>A	ENST00000424345.1	+	0	73																											tccaggatttgtccccagtgc	0.343000													3	17					0	0	0.115264	0	0
GALNT3	2591	broad.mit.edu	37	2	166611208	166611208	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:166611208C>G	ENST00000392701.3	-	9	2330	c.1555G>C	c.(1555-1557)Gat>Cat	p.D519H	GALNT3_ENST00000409882.1_Missense_Mutation_p.D257H	NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	519	Ricin B-type lectin.				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						TCTCCAACATCCAGACATAGA	0.318000													4	19					0	0	0.150653	0	0
ZNF607	84775	broad.mit.edu	37	19	38190779	38190779	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr19:38190779C>T	ENST00000355202.4	-	5	848	c.253G>A	c.(253-255)Gaa>Aaa	p.E85K	CTD-2528L19.4_ENST00000586606.2_Missense_Mutation_p.E85K|ZNF607_ENST00000395835.3_Missense_Mutation_p.E84K	NM_032689.4	NP_116078.4	Q96SK3	ZN607_HUMAN	zinc finger protein 607	85					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|lung(8)|urinary_tract(1)	27			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			CTGATTATTTCACATCTTGAA	0.313000													3	20					0	0	0.115264	0	0
SYNE1	23345	broad.mit.edu	37	6	152718022	152718022	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:152718022C>A	ENST00000367255.5	-	50	8045	c.7444G>T	c.(7444-7446)Gtc>Ttc	p.V2482F	SYNE1_ENST00000341594.5_Missense_Mutation_p.V2521F|SYNE1_ENST00000448038.1_Missense_Mutation_p.V2489F|SYNE1_ENST00000265368.4_Missense_Mutation_p.V2482F|SYNE1_ENST00000423061.1_Missense_Mutation_p.V2489F	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2482					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATGCTACTGACAATTTGTTTA	0.393000										HNSCC(10;0.0054)			9	58					1.12685e-05	1.22579e-05	0.047766	1	0
CYB5RL	606495	broad.mit.edu	37	1	54661235	54661235	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:54661235G>A	ENST00000419823.2	-	2	279	c.55C>T	c.(55-57)Cgg>Tgg	p.R19W	CYB5RL_ENST00000542737.1_Missense_Mutation_p.R19W|CYB5RL_ENST00000534324.1_Missense_Mutation_p.R19W|CYB5RL_ENST00000497820.1_Missense_Mutation_p.R19W|CYB5RL_ENST00000537208.1_Missense_Mutation_p.R19W|MRPL37_ENST00000487096.1_Intron|CYB5RL_ENST00000401046.3_De_novo_Start_InFrame|RP11-446E24.4_ENST00000311841.7_Missense_Mutation_p.R19W|CYB5RL_ENST00000287899.8_Missense_Mutation_p.R19W	NM_001031672.2	NP_001026842.2	Q6IPT4	NB5R5_HUMAN	cytochrome b5 reductase-like	19							cytochrome-b5 reductase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|urinary_tract(1)	8						TCTGTGGGCCGTAGCTGCATC	0.597000													27	71					0	0	0.144211	0	0
FBXW7	55294	broad.mit.edu	37	4	153249384	153249384	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:153249384C>T	ENST00000281708.4	-	9	2623	c.1394G>A	c.(1393-1395)cGt>cAt	p.R465H	FBXW7_ENST00000263981.5_Missense_Mutation_p.R385H|FBXW7_ENST00000393956.3_Missense_Mutation_p.R289H|FBXW7_ENST00000603841.1_Missense_Mutation_p.R465H|FBXW7_ENST00000296555.5_Missense_Mutation_p.R347H|FBXW7_ENST00000603548.1_Missense_Mutation_p.R465H	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	465			R -> C (in a acute lymphoblastic leukemia cell line).|R -> H (in a colorectal cancer sample; somatic mutation).		interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R465H(69)|p.R385H(16)|p.R226H(16)|p.R465L(4)|p.R347H(4)|p.R465Y(2)|p.?(1)|p.R385L(1)|p.R226L(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ATGCATACAACGCACAGTGGA	0.408000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								22	144					0	0	0.076483	0	0
ALAD	210	broad.mit.edu	37	9	116151291	116151291	+	Silent	SNP	G	G	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:116151291G>C	ENST00000409155.3	-	11	1093	c.897C>G	c.(895-897)gcC>gcG	p.A299A	ALAD_ENST00000277315.5_Silent_p.A282A	NM_000031.5	NP_000022.3	P13716	HEM2_HUMAN	aminolevulinate dehydratase	299					heme biosynthetic process|protein homooligomerization	cytosol	identical protein binding|lead ion binding|porphobilinogen synthase activity|zinc ion binding	p.A328A(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|stomach(1)	9					Aminolevulinic acid(DB00855)	CCTCCAGTACGGCAGCCTTGA	0.602000													3	13					0	0	0.150653	0	0
NEIL3	55247	broad.mit.edu	37	4	178260967	178260967	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:178260967C>T	ENST00000264596.3	+	5	776	c.658C>T	c.(658-660)Cac>Tac	p.H220Y		NM_018248.2	NP_060718.2	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3 (E. coli)	220					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		ACAGATCCATCACCTCATGAA	0.353000								Base excision repair (BER), DNA glycosylases					4	28					0	0	0.014758	0	0
CDH10	1008	broad.mit.edu	37	5	24593560	24593560	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:24593560C>G	ENST00000264463.4	-	2	547	c.40G>C	c.(40-42)Gta>Cta	p.V14L	RP11-116O11.1_ENST00000510391.1_RNA	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	14					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GGCAGGCATACCCAGAATAGA	0.413000										HNSCC(23;0.051)			10	62					0	0	0.069234	0	0
ZNF260	339324	broad.mit.edu	37	19	37005579	37005579	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr19:37005579C>T	ENST00000523638.1	-	3	1683	c.562G>A	c.(562-564)Gga>Aga	p.G188R	ZNF260_ENST00000588993.1_Missense_Mutation_p.G188R|ZNF260_ENST00000592282.1_Missense_Mutation_p.G188R|ZNF260_ENST00000593142.1_Missense_Mutation_p.G188R	NM_001166036.1|NM_001166037.1|NM_001166038.1	NP_001159508.1|NP_001159509.1|NP_001159510.1	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	188					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)	15	Esophageal squamous(110;0.162)					GGCTTCTTTCCAGTATGGATG	0.378000													23	46					0	0	0.076483	0	0
PTPRE	5791	broad.mit.edu	37	10	129861400	129861400	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr10:129861400T>C	ENST00000254667.3	+	10	958	c.679T>C	c.(679-681)Tct>Cct	p.S227P	PTPRE_ENST00000419012.2_Missense_Mutation_p.S227P|PTPRE_ENST00000306042.5_Missense_Mutation_p.S169P|PTPRE_ENST00000430713.2_3'UTR	NM_006504.4	NP_006495.1	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	227	Tyrosine-protein phosphatase 1.				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	22		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				GGAGCAAAAGTCTGCGACCAT	0.498000													13	39					0	0	0.105934	0	0
CARD6	84674	broad.mit.edu	37	5	40853691	40853691	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:40853691A>T	ENST00000254691.5	+	3	2456	c.2257A>T	c.(2257-2259)Atg>Ttg	p.M753L	CARD6_ENST00000381677.3_Intron	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	753					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						CTCCTGGGTTATGGGCCGCCC	0.507000													36	238					0	0	0.086207	0	0
LDLRAP1	26119	broad.mit.edu	37	1	25881403	25881403	+	Missense_Mutation	SNP	G	G	A	rs139877665	byFrequency	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:25881403G>A	ENST00000374338.4	+	3	403	c.284G>A	c.(283-285)cGg>cAg	p.R95Q	LDLRAP1_ENST00000488127.1_3'UTR	NM_015627.2	NP_056442.2	Q5SW96	ARH_HUMAN	low density lipoprotein receptor adaptor protein 1	95	PID.				amyloid precursor protein metabolic process|cholesterol homeostasis|cholesterol metabolic process|positive regulation of receptor-mediated endocytosis|receptor internalization|receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport|regulation of establishment of protein localization in plasma membrane|regulation of protein binding	basal plasma membrane|cytosol|early endosome|internal side of plasma membrane|neurofilament|recycling endosome	beta-amyloid binding|clathrin binding|low-density lipoprotein particle receptor binding|phosphatidylinositol-4,5-bisphosphate binding|phosphotyrosine binding|protein binding, bridging|protein complex binding|receptor signaling complex scaffold activity|signaling adaptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|ovary(1)|skin(1)|urinary_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.63e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|GBM - Glioblastoma multiforme(114;0.00914)|READ - Rectum adenocarcinoma(331;0.0649)		GTGTCGCCACGGGGAATTATC	0.552000													4	15					0	0	0.150653	0	0
LRP1	4035	broad.mit.edu	37	12	57593171	57593171	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:57593171C>T	ENST00000243077.3	+	61	10319	c.9853C>T	c.(9853-9855)Cgc>Tgc	p.R3285C		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3285					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCATGCCCTGCGCCAGCCAGA	0.617000													8	43					0	0	0.093190	0	0
ZNF510	22869	broad.mit.edu	37	9	99522314	99522314	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:99522314C>A	ENST00000375231.1	-	6	1448	c.798G>T	c.(796-798)aaG>aaT	p.K266N	ZNF510_ENST00000223428.4_Missense_Mutation_p.K266N			Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	266					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	21		Acute lymphoblastic leukemia(62;0.0527)				CACAGTTAGCCTTATCATTAA	0.323000													5	20					0.014758	0.0153071	0.014758	1	0
CD226	10666	broad.mit.edu	37	18	67614224	67614224	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr18:67614224C>G	ENST00000280200.4	-	3	396	c.128G>C	c.(127-129)gGc>gCc	p.G43A	CD226_ENST00000577287.1_Intron|CD226_ENST00000581982.1_Intron|CD226_ENST00000582621.1_Missense_Mutation_p.G43A	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	43	Ig-like C2-type 1.				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				TGTTAAGATGCCCATTGATGG	0.463000													13	41					0	0	0.093190	0	0
SERTAD4	56256	broad.mit.edu	37	1	210415316	210415316	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:210415316G>A	ENST00000367012.3	+	4	935	c.705G>A	c.(703-705)ttG>ttA	p.L235L	SERTAD4_ENST00000490620.1_3'UTR	NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	235	Ser-rich.						protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		ctccccctTTGCCTTTACCGA	0.493000													4	59					0	0	0.150653	0	0
TRIM3	10612	broad.mit.edu	37	11	6477334	6477334	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:6477334C>T	ENST00000525074.1	-	7	1895	c.1501G>A	c.(1501-1503)Gtg>Atg	p.V501M	TRIM3_ENST00000537602.1_Missense_Mutation_p.V423M|TRIM3_ENST00000536344.1_Missense_Mutation_p.V382M|TRIM3_ENST00000359518.3_Missense_Mutation_p.V501M|TRIM3_ENST00000345851.3_Missense_Mutation_p.V501M	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	501					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTGCTACCACGATGCGGCCG	0.502000													8	48					0	0	0.080935	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135772779	135772779	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:135772779C>T	ENST00000250617.6	-	10	2380	c.1175G>A	c.(1174-1176)cGg>cAg	p.R392Q	ARHGEF6_ENST00000370620.1_Missense_Mutation_p.R238Q|ARHGEF6_ENST00000370622.1_Missense_Mutation_p.R238Q|ARHGEF6_ENST00000535227.1_Missense_Mutation_p.R265Q	NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	392	DH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					CTCCATATGCCGTTCTAACTC	0.473000													11	47					0	0	0.080935	0	0
LOC644669	644669	broad.mit.edu	37	18	15323276	15323276	+	RNA	SNP	A	A	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr18:15323276A>T	ENST00000455308.2	-	0	572					NR_027417.1																						ATCAACTGCAATTGCATTTGC	0.308000													4	5					0	0	0.014758	0	0
FRMPD1	22844	broad.mit.edu	37	9	37746019	37746019	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:37746019G>A	ENST00000539465.1	+	16	4583	c.3990G>A	c.(3988-3990)ggG>ggA	p.G1330G	FRMPD1_ENST00000377765.3_Silent_p.G1330G|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1330						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CCAGGATAGGGATGGACCAGT	0.567000													43	100					0	0	0.131918	0	0
PIGL	9487	broad.mit.edu	37	17	16203255	16203255	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr17:16203255T>G	ENST00000225609.5	+	3	406	c.389T>G	c.(388-390)gTc>gGc	p.V130G	PIGL_ENST00000395844.3_Missense_Mutation_p.V130G|PIGL_ENST00000498772.2_Missense_Mutation_p.V130G|PIGL_ENST00000581006.1_Missense_Mutation_p.V130G	NM_004278.3	NP_004269.1	Q9Y2B2	PIGL_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class L	130					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminylphosphatidylinositol deacetylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)	11				UCEC - Uterine corpus endometrioid carcinoma (92;0.0934)		GTGGCCAGAGTCCTCCTTCAG	0.507000													20	43					0	0	0.043863	0	0
OR52B2	255725	broad.mit.edu	37	11	6191530	6191530	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:6191530G>A	ENST00000530810.1	-	1	108	c.27C>T	c.(25-27)ttC>ttT	p.F9F	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGCAGGATGGAAGATGGTAA	0.438000													12	119					0	0	0.105934	0	0
DEFB119	245932	broad.mit.edu	37	20	29965049	29965049	+	Nonstop_Mutation	SNP	T	T	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr20:29965049T>C	ENST00000376321.3	-	2	374	c.255A>G	c.(253-255)tgA>tgG	p.*85W	DEFB119_ENST00000492344.1_5'UTR|DEFB119_ENST00000339144.3_3'UTR	NM_153289.2	NP_695021.2	Q8N690	DB119_HUMAN	defensin, beta 119	0					defense response to bacterium	extracellular region				large_intestine(2)|lung(1)|prostate(1)	4	all_hematologic(12;0.158)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			TCACCAGCACTCAAGGTAGTC	0.493000													6	144					0	0	0.021553	0	0
CDC37	11140	broad.mit.edu	37	19	10504047	10504047	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr19:10504047C>T	ENST00000222005.2	-	6	850	c.797G>A	c.(796-798)cGt>cAt	p.R266H		NM_007065.3	NP_008996.1	Q16543	CDC37_HUMAN	cell division cycle 37	266					protein targeting|regulation of cyclin-dependent protein kinase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway		unfolded protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	16			OV - Ovarian serous cystadenocarcinoma(20;4.65e-10)|Epithelial(33;6.48e-07)|all cancers(31;2.31e-06)	GBM - Glioblastoma multiforme(1328;0.0318)		CAGCTTGGCACGGCCCCGCAC	0.652000													13	80					0	0	0.105934	0	0
PDCD2	5134	broad.mit.edu	37	6	170892657	170892657	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:170892657G>T	ENST00000541970.1	-	2	540	c.462C>A	c.(460-462)taC>taA	p.Y154*	PDCD2_ENST00000443345.2_Nonsense_Mutation_p.Y121*|PDCD2_ENST00000542896.1_Nonsense_Mutation_p.Y154*|PDCD2_ENST00000392090.2_Nonsense_Mutation_p.Y121*|PDCD2_ENST00000537445.1_Nonsense_Mutation_p.Y121*|PDCD2_ENST00000453163.2_Nonsense_Mutation_p.Y154*	NM_001199462.1|NM_002598.3	NP_001186391.1|NP_002589.2	Q16342	PDCD2_HUMAN	programmed cell death 2	154					apoptosis	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(1)|lung(5)	9		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.91e-23)|BRCA - Breast invasive adenocarcinoma(81;4.82e-06)|GBM - Glioblastoma multiforme(31;0.142)		CCTTGCTGCAGTAATATGCTT	0.478000													10	45					2.17888e-05	2.35869e-05	0.058154	1	0
KIAA0922	23240	broad.mit.edu	37	4	154519861	154519861	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:154519861C>T	ENST00000409959.3	+	21	2292	c.2243C>T	c.(2242-2244)tCc>tTc	p.S748F	KIAA0922_ENST00000440693.1_Missense_Mutation_p.S664F|KIAA0922_ENST00000409663.3_Missense_Mutation_p.S747F	NM_001131007.1	NP_001124479.1	A2VDJ0	T131L_HUMAN	KIAA0922	747						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				GTGCCCGAGTCCACGCTGATG	0.483000													5	15					0	0	0.014758	0	0
RXFP3	51289	broad.mit.edu	37	5	33937262	33937262	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:33937262G>A	ENST00000330120.3	+	1	772	c.417G>A	c.(415-417)gcG>gcA	p.A139A		NM_016568.3	NP_057652.1	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	139						integral to plasma membrane	N-formyl peptide receptor activity			endometrium(4)|large_intestine(9)|lung(24)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)	42						CCTTCTGGGCGGTGGAGAACG	0.557000													7	36					0	0	0.029380	0	0
DAPK1	1612	broad.mit.edu	37	9	90321154	90321154	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:90321154G>A	ENST00000469640.2	+	27	3618	c.3243G>A	c.(3241-3243)gcG>gcA	p.A1081A	DAPK1_ENST00000408954.3_Silent_p.A1056A|DAPK1_ENST00000358077.5_Silent_p.A1056A|DAPK1_ENST00000472284.1_Silent_p.A1056A|DAPK1_ENST00000491893.1_Silent_p.A990A			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1056					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						CCCCACGGGCGCTGCACCACT	0.637000									Chronic Lymphocytic Leukemia, Familial Clustering of				4	14					0	0	0.150653	0	0
CCDC39	339829	broad.mit.edu	37	3	180377345	180377345	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:180377345T>G	ENST00000273654.4	-	12	1504	c.885A>C	c.(883-885)caA>caC	p.Q295H	CCDC39_ENST00000442201.2_Missense_Mutation_p.Q211H			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	211					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TACGAAAATCTTGTGCTGCTT	0.338000													14	58					0	0	0.160694	0	0
CT47B1	643311	broad.mit.edu	37	X	120009284	120009284	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:120009284C>T	ENST00000371311.3	-	1	495	c.241G>A	c.(241-243)Gcc>Acc	p.A81T		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	81										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						TCCTCCTCGGCGCTCCCGCCC	0.721000													4	12					0	0	0.021553	0	0
PTPRC	5788	broad.mit.edu	37	1	198668831	198668831	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:198668831C>A	ENST00000367376.2	+	5	602	c.431C>A	c.(430-432)tCa>tAa	p.S144*	PTPRC_ENST00000352140.3_Nonsense_Mutation_p.S144*|PTPRC_ENST00000594404.1_Intron|PTPRC_ENST00000348564.6_Intron|PTPRC_ENST00000391970.3_3'UTR|PTPRC_ENST00000442510.2_Nonsense_Mutation_p.S146*	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	144					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						AATGCTATCTCAGGTTTGCGG	0.488000											OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	154					3.80469e-20	4.35101e-20	0.144211	1	0
LINGO4	339398	broad.mit.edu	37	1	151774060	151774060	+	Missense_Mutation	SNP	C	C	T	rs143135535		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:151774060C>T	ENST00000368820.3	-	2	2058	c.1121G>A	c.(1120-1122)cGc>cAc	p.R374H		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	374	LRRCT.					integral to membrane		p.R374H(1)		breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GTCCAGGTGGCGGCGGAGCCG	0.617000													5	13					0	0	0.093190	0	0
C3orf27	23434	broad.mit.edu	37	3	128292393	128292393	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:128292393G>A	ENST00000356020.2	-	3	1146	c.180C>T	c.(178-180)ctC>ctT	p.L60L		NM_007354.2	NP_031380.1	O15544	GR6_HUMAN	chromosome 3 open reading frame 27	60										large_intestine(2)|lung(5)|prostate(1)	8				GBM - Glioblastoma multiforme(114;0.176)		CCAGACCCCCGAGTGTCTCTG	0.622000													9	53					0	0	0.058154	0	0
FAM111A	63901	broad.mit.edu	37	11	58919346	58919346	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:58919346G>C	ENST00000528737.1	+	5	3023	c.205G>C	c.(205-207)Gac>Cac	p.D69H	FAM111A_ENST00000361723.3_Missense_Mutation_p.D69H|FAM111A_ENST00000531147.1_Missense_Mutation_p.D69H|FAM111A_ENST00000533703.1_Missense_Mutation_p.D69H|FAM111A_ENST00000420244.1_Missense_Mutation_p.D69H			Q96PZ2	F111A_HUMAN	family with sequence similarity 111, member A	69					proteolysis		serine-type endopeptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_epithelial(135;0.139)				AAATCCAGAAGACCAGACCAT	0.413000													3	112					0	0	0.150653	0	0
MAMLD1	10046	broad.mit.edu	37	X	149638793	149638793	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:149638793G>A	ENST00000370401.2	+	4	1258	c.948G>A	c.(946-948)ggG>ggA	p.G316G	MAMLD1_ENST00000426613.2_Silent_p.G291G|MAMLD1_ENST00000432680.2_Silent_p.G291G|MAMLD1_ENST00000262858.5_Silent_p.G316G			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	316					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					GCAAGCAGGGGTCTGCTACAA	0.647000													11	79					0	0	0.132662	0	0
A2ML1	144568	broad.mit.edu	37	12	9020881	9020881	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:9020881G>C	ENST00000299698.7	+	31	4169	c.3989G>C	c.(3988-3990)aGt>aCt	p.S1330T	A2ML1_ENST00000539547.1_Missense_Mutation_p.S839T	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	1174						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						TTTAGTCTTAGTGTGGAAATA	0.448000													5	182					0	0	0.014758	0	0
KIAA1755	85449	broad.mit.edu	37	20	36867983	36867983	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr20:36867983C>T	ENST00000279024.4	-	4	1965	c.1694G>A	c.(1693-1695)aGg>aAg	p.R565K		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	565										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				AGCCCCAATCCTGGGCTCAGG	0.632000													6	189					0	0	0.021553	0	0
DNAH11	8701	broad.mit.edu	37	7	21737769	21737769	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:21737769C>T	ENST00000328843.6	+	37	6170	c.6139C>T	c.(6139-6141)Cgt>Tgt	p.R2047C	DNAH11_ENST00000409508.3_Missense_Mutation_p.R2040C			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2047	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGTGGATGCGCGTGCATTAGC	0.418000									Kartagener syndrome				7	29					0	0	0.029380	0	0
ATP5A1	498	broad.mit.edu	37	18	43666458	43666458	+	Silent	SNP	G	G	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr18:43666458G>T	ENST00000593152.2	-	9	1568	c.1029C>A	c.(1027-1029)atC>atA	p.I343I	ATP5A1_ENST00000590665.1_Silent_p.I371I|ATP5A1_ENST00000398752.6_Silent_p.I393I|ATP5A1_ENST00000282050.2_Silent_p.I393I	NM_001257335.1	NP_001244264.1	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	393					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|skin(1)|urinary_tract(1)	22						TTTCCAAGAAGATCTATAATG	0.403000													4	15					0.0215528	0.0222512	0.021553	1	0
MYOF	26509	broad.mit.edu	37	10	95162103	95162103	+	Splice_Site	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr10:95162103G>A	ENST00000371501.4	-	11	998	c.874_splice	c.e11-1	p.G292_splice	MYOF_ENST00000358334.5_Splice_Site_p.G292_splice|MYOF_ENST00000371489.1_Splice_Site_p.G292_splice|MYOF_ENST00000371502.4_Splice_Site_p.G292_splice|MYOF_ENST00000359263.4_Splice_Site_p.G292_splice			Q9NZM1	MYOF_HUMAN	myoferlin	292					blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			NS(2)|autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(7)|large_intestine(15)|lung(14)|ovary(4)|prostate(4)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TGACAGCATGGCCTAAAATAG	0.418000													11	47					0	0	0.119110	0	0
ABCC8	6833	broad.mit.edu	37	11	17464266	17464266	+	Splice_Site	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:17464266C>T	ENST00000302539.4	-	10	1756		c.e10+1		ABCC8_ENST00000528202.1_Splice_Site|ABCC8_ENST00000389817.3_Splice_Site	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8						carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GGTGAACTCACTGGAGATGGA	0.612000													12	50					0	0	0.119110	0	0
AIM2	9447	broad.mit.edu	37	1	159035745	159035745	+	Silent	SNP	A	A	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:159035745A>G	ENST00000368130.4	-	4	1059	c.771T>C	c.(769-771)acT>acC	p.T257T	AIM2_ENST00000481829.1_5'UTR	NM_004833.1	NP_004824.1	O14862	AIM2_HUMAN	absent in melanoma 2	257	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				breast(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(1)	16	all_hematologic(112;0.0429)					CAAGGGGCTGAGTTTGAAGCG	0.393000													13	66					0	0	0.119110	0	0
AK7	122481	broad.mit.edu	37	14	96917885	96917885	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr14:96917885A>G	ENST00000267584.4	+	10	1120	c.1076A>G	c.(1075-1077)tAc>tGc	p.Y359C		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	359					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CTCAAGGAGTACAAGCAAAGC	0.393000													4	26					0	0	0.014758	0	0
SCN8A	6334	broad.mit.edu	37	12	52201020	52201020	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:52201020G>T	ENST00000354534.5	+	27	5928	c.5750G>T	c.(5749-5751)tGc>tTc	p.C1917F	SCN8A_ENST00000545061.1_Missense_Mutation_p.C1876F	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1917	IQ.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	GGCTTCATCTGCAAAAAGACA	0.547000													17	83					1.99824e-07	2.22803e-07	0.160694	1	0
CHRM2	1129	broad.mit.edu	37	7	136700368	136700368	+	Silent	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:136700368C>T	ENST00000445907.2	+	3	1284	c.756C>T	c.(754-756)gaC>gaT	p.D252D	CHRM2_ENST00000397608.3_Silent_p.D252D|AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000593789.1_RNA|CHRM2_ENST00000453373.1_Silent_p.D252D|CHRM2_ENST00000401861.1_Silent_p.D252D|CHRM2_ENST00000320658.5_Silent_p.D252D|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000592183.1_RNA|CHRM2_ENST00000402486.3_Silent_p.D252D|AC009264.1_ENST00000425981.2_RNA|AC009264.1_ENST00000586239.1_RNA|AC009264.1_ENST00000598184.1_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	252					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CCAGCAGTGACGATGGCCTGG	0.507000													6	24					0	0	0.029380	0	0
KRT6C	286887	broad.mit.edu	37	12	52865969	52865969	+	Silent	SNP	C	C	T	rs147574610		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:52865969C>T	ENST00000252250.6	-	2	683	c.636G>A	c.(634-636)ccG>ccA	p.P212P		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	212	Linker 1.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GCTCGAACAACGGCTCCAGGT	0.602000													11	42					0	0	0.146539	0	0
NOTCH2	4853	broad.mit.edu	37	1	120539849	120539849	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:120539849G>A	ENST00000256646.2	-	4	741	c.522C>T	c.(520-522)ttC>ttT	p.F174F	NOTCH2_ENST00000602566.1_Silent_p.F135F	NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	174	EGF-like 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTGCCCTGTGAAGCCTGTGA	0.547000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				36	65					0	0	0.074837	0	0
KRT34	3885	broad.mit.edu	37	17	39535236	39535236	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr17:39535236G>A	ENST00000394001.1	-	6	1225	c.1195C>T	c.(1195-1197)Cgg>Tgg	p.R399W		NM_021013.3	NP_066293.2	O76011	KRT34_HUMAN	keratin 34	399	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				AGGAGGCTCCGGTACGTGTTG	0.562000													86	148					0	0	0.139131	0	0
BNIP3P1	319138	broad.mit.edu	37	14	28734125	28734125	+	RNA	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr14:28734125C>T	ENST00000550043.1	+	0	530																											TTGGTCAAGTCGGCCGGAAAA	0.478000													10	33					0	0	0.069234	0	0
GART	2618	broad.mit.edu	37	21	34903822	34903822	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr21:34903822T>G	ENST00000381831.3	-	6	833	c.570A>C	c.(568-570)gaA>gaC	p.E190D	GART_ENST00000381839.3_Missense_Mutation_p.E190D|GART_ENST00000361093.5_Missense_Mutation_p.E190D|GART_ENST00000497313.1_5'UTR|GART_ENST00000381815.4_Missense_Mutation_p.E190D	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	190	ATP-grasp.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	CAAGAAGTTCTTCAATGACAA	0.358000													6	72					0	0	0.047766	0	0
CCDC125	202243	broad.mit.edu	37	5	68578628	68578628	+	Silent	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:68578628C>T	ENST00000396496.2	-	12	1571	c.1464G>A	c.(1462-1464)caG>caA	p.Q488Q	CCDC125_ENST00000511257.1_Silent_p.Q363Q|CCDC125_ENST00000383374.2_3'UTR|CCDC125_ENST00000396499.1_Silent_p.Q488Q|CCDC125_ENST00000460090.1_5'UTR			Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	488						cytoplasm				breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|urinary_tract(1)	19		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		TTTGAGAGTGCTGGATTGAAC	0.378000													3	51					0	0	0.115264	0	0
UMODL1	89766	broad.mit.edu	37	21	43519072	43519072	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr21:43519072T>A	ENST00000400427.1	+	7	1148	c.752T>A	c.(751-753)gTc>gAc	p.V251D	UMODL1_ENST00000408989.2_Missense_Mutation_p.V323D|UMODL1_ENST00000400424.1_Missense_Mutation_p.V251D|UMODL1_ENST00000408910.2_Missense_Mutation_p.V323D	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	323						cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						GTCCTCAACGTCACCAGTGAC	0.507000													10	108					0	0	0.069234	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28338433	28338433	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr21:28338433G>A	ENST00000284987.5	-	1	399	c.278C>T	c.(277-279)gCg>gTg	p.A93V		NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	93					proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						CCGGCCGCCCGCGTAGACGAG	0.701000													12	27					0	0	0.146539	0	0
OR4C15	81309	broad.mit.edu	37	11	55322168	55322168	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:55322168T>C	ENST00000314644.2	+	1	386	c.386T>C	c.(385-387)gTc>gCc	p.V129A		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TTCTCATCTGTCATCACCCCA	0.468000										HNSCC(20;0.049)			10	190					0	0	0.080935	0	0
OR2T27	403239	broad.mit.edu	37	1	248813367	248813367	+	Silent	SNP	A	A	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:248813367A>G	ENST00000344889.3	-	1	818	c.819T>C	c.(817-819)gcT>gcC	p.A273A		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	273					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGCAGATACAGCTTTGTCCT	0.522000													12	45					0	0	0.105934	0	0
CPO	130749	broad.mit.edu	37	2	207814376	207814376	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:207814376A>C	ENST00000272852.3	+	2	150	c.104A>C	c.(103-105)aAg>aCg	p.K35T		NM_173077.2	NP_775100.1	Q8IVL8	CBPO_HUMAN	carboxypeptidase O	35					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	14				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		ATTGTGGACAAGTCAGTGAGT	0.502000													13	67					0	0	0.119110	0	0
OR51I2	390064	broad.mit.edu	37	11	5475386	5475386	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:5475386G>A	ENST00000341449.2	+	1	749	c.668G>A	c.(667-669)cGt>cAt	p.R223H	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R223H(1)		endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCATTCTGCGTTCTGTCATG	0.448000													17	103					0	0	0.049695	0	0
CNR1	1268	broad.mit.edu	37	6	88853987	88853987	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:88853987C>T	ENST00000537554.1	-	2	4569	c.1007G>A	c.(1006-1008)cGc>cAc	p.R336H	CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000428600.2_Missense_Mutation_p.R336H|CNR1_ENST00000468898.1_Missense_Mutation_p.R303H|CNR1_ENST00000369501.2_Missense_Mutation_p.R336H|CNR1_ENST00000549716.1_Missense_Mutation_p.R275H|CNR1_ENST00000369499.2_Missense_Mutation_p.R336H|CNR1_ENST00000549890.1_Missense_Mutation_p.R336H|CNR1_ENST00000535130.1_Missense_Mutation_p.R336H	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	336					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding	p.R336H(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	AATGTCCATGCGGGCTTGGTC	0.567000													3	77					0	0	0.115264	0	0
FAT2	2196	broad.mit.edu	37	5	150905367	150905367	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:150905367T>C	ENST00000261800.5	-	17	10480	c.10468A>G	c.(10468-10470)Agc>Ggc	p.S3490G		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	3490	Cadherin 31.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCCCTCCTGCTTAGGCCCTCA	0.572000													6	49					0	0	0.021553	0	0
FAM71E1	112703	broad.mit.edu	37	19	50979509	50979509	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr19:50979509G>T	ENST00000600100.1	-	1	501	c.137C>A	c.(136-138)cCt>cAt	p.P46H	FAM71E1_ENST00000595790.1_Missense_Mutation_p.P46H			Q6IPT2	F71E1_HUMAN	family with sequence similarity 71, member E1	46										breast(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		GAGAAAGCGAGGGGGCGGGAC	0.657000													3	7					0.00909568	0.00956763	0.150653	1	0
FDFT1	2222	broad.mit.edu	37	8	11667355	11667355	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr8:11667355C>A	ENST00000220584.4	+	3	599	c.377C>A	c.(376-378)cCa>cAa	p.P126Q	FDFT1_ENST00000528643.1_Missense_Mutation_p.P41Q|FDFT1_ENST00000538689.1_Missense_Mutation_p.P15Q|FDFT1_ENST00000525900.1_Missense_Mutation_p.P119Q|FDFT1_ENST00000446331.2_Intron|FDFT1_ENST00000530664.1_Missense_Mutation_p.P62Q|FDFT1_ENST00000528812.1_Missense_Mutation_p.P62Q|FDFT1_ENST00000525777.1_Missense_Mutation_p.P41Q|FDFT1_ENST00000443614.2_Missense_Mutation_p.P126Q	NM_004462.3	NP_004453.3	P37268	FDFT_HUMAN	farnesyl-diphosphate farnesyltransferase 1	126					cholesterol biosynthetic process|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	farnesyl-diphosphate farnesyltransferase activity|oxidoreductase activity|protein binding|squalene synthase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)	12	all_epithelial(15;0.234)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.18)		GAGGACTTCCCAACGGTGAGT	0.498000													3	13					0.004672	0.00496122	0.115264	1	0
TRIP12	9320	broad.mit.edu	37	2	230724133	230724133	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:230724133G>A	ENST00000283943.5	-	3	434	c.256C>T	c.(256-258)Cct>Tct	p.P86S	TRIP12_ENST00000389045.3_Intron|TRIP12_ENST00000389044.4_Missense_Mutation_p.P128S|TRIP12_ENST00000409677.1_Missense_Mutation_p.P128S|TRIP12_ENST00000543084.1_Missense_Mutation_p.P128S	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	86					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		GCAGAGCTAGGAGAATTGGTC	0.428000													25	88					0	0	0.076483	0	0
MT-CO3	4514	broad.mit.edu	37	MT	9575	9575	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrM:9575G>C	ENST00000362079.2	+	1	369	c.369G>C	c.(367-369)ccG>ccC	p.123_123insP						mitochondrially encoded cytochrome c oxidase III											breast(1)|endometrium(10)|kidney(14)|lung(1)|urinary_tract(1)	27						GGCATCACCCCGCTAAATCCC	0.498000													105	218					0	0	0.139131	0	0
KAT2A	2648	broad.mit.edu	37	17	40269436	40269436	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr17:40269436T>A	ENST00000225916.5	-	10	1660	c.1607A>T	c.(1606-1608)aAg>aTg	p.K536M		NM_021078.2	NP_066564.2	Q92830	KAT2A_HUMAN	K(lysine) acetyltransferase 2A	536	N-acetyltransferase.				chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						GATATACTCCTTAGGCATGCG	0.642000													3	20					0	0	0.115264	0	0
CCDC170	80129	broad.mit.edu	37	6	151859418	151859418	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:151859418A>G	ENST00000367290.5	+	3	514	c.425A>G	c.(424-426)gAg>gGg	p.E142G	CCDC170_ENST00000544131.1_3'UTR|CCDC170_ENST00000239374.7_Missense_Mutation_p.E142G			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	142																	AAAGTTGTAGAGTTAAATGAA	0.343000													4	62					0	0	0.014758	0	0
TSHZ1	10194	broad.mit.edu	37	18	73000513	73000513	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr18:73000513G>A	ENST00000322038.5	+	2	3600	c.3016G>A	c.(3016-3018)Gca>Aca	p.A1006T	TSHZ1_ENST00000580243.1_Missense_Mutation_p.A1051T	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	1051						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		GAGCAAGCACGCAGTCAAACT	0.542000													10	42					0	0	0.080935	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113634553	113634553	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:113634553G>A	ENST00000358160.4	+	10	1450	c.958G>A	c.(958-960)Gtt>Att	p.V320I	GRAMD1C_ENST00000479212.1_3'UTR|GRAMD1C_ENST00000472026.1_Missense_Mutation_p.V153I|GRAMD1C_ENST00000440446.2_Missense_Mutation_p.V115I|GRAMD1C_ENST00000452134.2_Missense_Mutation_p.V49I	NM_017577.4	NP_060047.3	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	320						integral to membrane				NS(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	26						TCCAGAAAATGTTCCTGAGAA	0.328000													3	18					0	0	0.150653	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655812	40655812	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:40655812C>T	ENST00000406785.1	-	2	1798	c.1609G>A	c.(1609-1611)Gca>Aca	p.A537T	SLC8A1_ENST00000405901.3_Missense_Mutation_p.A537T|SLC8A1_ENST00000408028.2_Missense_Mutation_p.A537T|SLC8A1_ENST00000406391.2_Missense_Mutation_p.A537T|SLC8A1_ENST00000405269.1_Missense_Mutation_p.A537T|SLC8A1_ENST00000332839.4_Missense_Mutation_p.A537T|SLC8A1_ENST00000542756.1_Missense_Mutation_p.A537T|SLC8A1_ENST00000403092.1_Missense_Mutation_p.A537T|SLC8A1_ENST00000542024.1_Missense_Mutation_p.A537T|SLC8A1_ENST00000402441.1_Missense_Mutation_p.A537T			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	537	Calx-beta 2.				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding	p.A537T(1)		NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AAAATGCCTGCGTGGTCATCA	0.453000													9	58					0	0	0.058154	0	0
FRG1B	284802	broad.mit.edu	37	20	29625934	29625934	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr20:29625934C>T	ENST00000278882.3	+	5	558	c.178C>T	c.(178-180)Cat>Tat	p.H60Y	FRG1B_ENST00000439954.2_Missense_Mutation_p.H65Y|FRG1B_ENST00000358464.4_Missense_Mutation_p.H60Y																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ACTTGTTGGGCATTCAGATGC	0.338000													4	82					0	0	0.029380	0	0
OXR1	55074	broad.mit.edu	37	8	107763109	107763109	+	Silent	SNP	T	T	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr8:107763109T>C	ENST00000445937.1	+	16	2742	c.2481T>C	c.(2479-2481)cgT>cgC	p.R827R	OXR1_ENST00000517566.2_Silent_p.R854R|OXR1_ENST00000449762.2_Silent_p.R197R|OXR1_ENST00000297447.6_Silent_p.R224R|OXR1_ENST00000531443.1_Silent_p.R827R|OXR1_ENST00000312046.6_Silent_p.R820R|OXR1_ENST00000521592.1_Silent_p.R100R|OXR1_ENST00000442977.2_Silent_p.R855R|OXR1_ENST00000452423.2_Silent_p.R275R	NM_018002.3	NP_060472.2	Q8N573	OXR1_HUMAN	oxidation resistance 1	855	TLD.				cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion				NS(2)|breast(2)|endometrium(2)|large_intestine(9)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			TTGGGAATCGTACACTTTCTA	0.373000													9	47					0	0	0.058154	0	0
BRIX1	55299	broad.mit.edu	37	5	34924964	34924964	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:34924964G>C	ENST00000336767.5	+	9	1039	c.676G>C	c.(676-678)Gat>Cat	p.D226H	BRIX1_ENST00000506023.1_3'UTR	NM_018321.3	NP_060791.3	Q8TDN6	BRX1_HUMAN	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)	226	Brix.				ribosome biogenesis|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(1)|large_intestine(2)|lung(1)	4						CATAGAAGAAGATGCTGCTCT	0.338000													4	29					0	0	0.014758	0	0
CELSR2	1952	broad.mit.edu	37	1	109807587	109807587	+	Silent	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:109807587C>T	ENST00000271332.3	+	12	5623	c.5562C>T	c.(5560-5562)acC>acT	p.T1854T		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1854	EGF-like 6; calcium-binding.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		ATGGCTATACCTGCGAGTGTC	0.562000													19	87					0	0	0.062417	0	0
WNK1	65125	broad.mit.edu	37	12	977239	977239	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:977239A>G	ENST00000537687.1	+	9	2990	c.2347A>G	c.(2347-2349)Agt>Ggt	p.S783G	WNK1_ENST00000535572.1_Intron|WNK1_ENST00000530271.2_Missense_Mutation_p.S868G|WNK1_ENST00000315939.6_Intron|WNK1_ENST00000574564.1_Missense_Mutation_p.S82G|WNK1_ENST00000340908.4_Intron	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	0					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TGTTGGCCAAAGTCTTCTTCC	0.542000													11	550					0	0	0.105934	0	0
NEK11	79858	broad.mit.edu	37	3	131068579	131068579	+	Nonstop_Mutation	SNP	A	A	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:131068579A>T	ENST00000510688.1	+	16	2024	c.1800A>T	c.(1798-1800)tgA>tgT	p.*600C	NEK11_ENST00000412440.2_Missense_Mutation_p.I449F|NEK11_ENST00000383366.4_Missense_Mutation_p.I633F|RP11-933H2.4_ENST00000513905.1_RNA|NEK11_ENST00000508196.1_Missense_Mutation_p.I633F|NEK11_ENST00000429253.2_Missense_Mutation_p.I633F|NEK11_ENST00000510769.1_Missense_Mutation_p.I528F|RP11-933H2.4_ENST00000502521.1_RNA	NM_001146003.1	NP_001139475.1	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11	0					cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|stomach(1)|urinary_tract(2)	33						GCAGTTGCTGATCACGATGGG	0.433000													9	83					0	0	0.047766	0	0
GEMIN8	54960	broad.mit.edu	37	X	14038377	14038377	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:14038377G>T	ENST00000380523.4	-	4	610	c.292C>A	c.(292-294)Cag>Aag	p.Q98K	GEMIN8_ENST00000460203.1_5'UTR|GEMIN8_ENST00000398355.3_Missense_Mutation_p.Q98K	NM_017856.2	NP_060326.1	Q9NWZ8	GEMI8_HUMAN	gem (nuclear organelle) associated protein 8	98					spliceosomal snRNP assembly	Cajal body|cytoplasm|SMN complex|spliceosomal complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	9						CGTGGATGCTGCCCAGATCTT	0.493000													26	105					3.73988e-18	4.25507e-18	0.116897	1	0
PTPRN	5798	broad.mit.edu	37	2	220166981	220166981	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:220166981G>A	ENST00000295718.2	-	6	1112	c.872C>T	c.(871-873)gCc>gTc	p.A291V	PTPRN_ENST00000409251.3_Missense_Mutation_p.A291V|PTPRN_ENST00000423636.2_Missense_Mutation_p.A201V|AC114803.3_ENST00000417355.1_RNA	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	291					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TGGCACCCTGGCCCTGCTGGG	0.632000													21	33					0	0	0.049695	0	0
IKZF5	64376	broad.mit.edu	37	10	124753876	124753876	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr10:124753876T>C	ENST00000368886.5	-	5	1000	c.680A>G	c.(679-681)tAt>tGt	p.Y227C	PSTK_ENST00000497219.1_Intron	NM_001271840.1	NP_001258769.1	Q9H5V7	IKZF5_HUMAN	IKAROS family zinc finger 5 (Pegasus)	227					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|lung(3)|prostate(1)	6		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		CATACTTTCATAGGAGTCAGT	0.463000													23	109					0	0	0.069288	0	0
ABCG1	9619	broad.mit.edu	37	21	43708163	43708163	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr21:43708163C>T	ENST00000398437.1	+	10	1724	c.1576C>T	c.(1576-1578)Cga>Tga	p.R526*	ABCG1_ENST00000347800.2_Intron|ABCG1_ENST00000462050.1_Intron|ABCG1_ENST00000340588.4_Nonsense_Mutation_p.R488*|ABCG1_ENST00000398449.3_Intron|ABCG1_ENST00000398457.2_Intron|ABCG1_ENST00000343687.3_Intron|ABCG1_ENST00000361802.2_Nonsense_Mutation_p.R380*			P45844	ABCG1_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 1	380	ABC transmembrane type-2.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(3)|prostate(2)|stomach(1)	29					Adenosine triphosphate(DB00171)	GCAGACAAAACGATTAAAGGG	0.562000													39	179					0	0	0.092188	0	0
TPR	7175	broad.mit.edu	37	1	186307308	186307308	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:186307308T>A	ENST00000367478.3	-	31	4515	c.4219A>T	c.(4219-4221)Aga>Tga	p.R1407*		NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	1407					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TTTTCAGTTCTTACTTTATTT	0.308000			T	NTRK1	papillary thyroid								3	22					0	0	0.150653	0	0
TTK	7272	broad.mit.edu	37	6	80750407	80750407	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:80750407T>G	ENST00000509894.1	+	21	3303	c.2474T>G	c.(2473-2475)tTg>tGg	p.L825W	TTK_ENST00000230510.3_Missense_Mutation_p.L825W|TTK_ENST00000369798.2_Missense_Mutation_p.L826W			P33981	TTK_HUMAN	TTK protein kinase	826					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		AACTCCATTTTGAAAGCTGCT	0.323000													10	40					0	0	0.080935	0	0
WNK3	65267	broad.mit.edu	37	X	54335697	54335697	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:54335697G>T	ENST00000354646.2	-	4	1200	c.762C>A	c.(760-762)tgC>tgA	p.C254*	WNK3_ENST00000375159.2_Nonsense_Mutation_p.C254*|WNK3_ENST00000375169.3_Nonsense_Mutation_p.C254*	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	254	Protein kinase.				intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						AAATTTGCCTGCACCAGCTCC	0.393000													17	28					1.5739e-10	1.77262e-10	0.146539	1	0
GRIA2	2891	broad.mit.edu	37	4	158282246	158282246	+	Silent	SNP	A	A	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:158282246A>G	ENST00000264426.9	+	14	2655	c.2376A>G	c.(2374-2376)ggA>ggG	p.G792G	GRIA2_ENST00000296526.7_Intron|GRIA2_ENST00000449365.1_Intron|GRIA2_ENST00000507898.1_Intron|GRIA2_ENST00000393815.2_Intron	NM_001083619.1	NP_001077088.1	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	792					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	ACGACAAAGGAGAGTGCGGCA	0.448000													7	33					0	0	0.038147	0	0
SIM1	6492	broad.mit.edu	37	6	100841682	100841682	+	Silent	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:100841682C>T	ENST00000369208.3	-	11	2033	c.1251G>A	c.(1249-1251)ccG>ccA	p.P417P	SIM1_ENST00000262901.4_Silent_p.P417P			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	417	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CCAGAAGCTGCGGAGAGGCCG	0.592000													20	25					0	0	0.062417	0	0
SLITRK6	84189	broad.mit.edu	37	13	86370440	86370440	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr13:86370440T>A	ENST00000400286.2	-	2	802	c.204A>T	c.(202-204)caA>caT	p.Q68H		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	68						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		ATAAGCTTAGTTGGAAAGGTC	0.373000													12	82					0	0	0.132662	0	0
LZTR1	8216	broad.mit.edu	37	22	21344731	21344731	+	Silent	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr22:21344731C>T	ENST00000215739.8	+	8	1067	c.708C>T	c.(706-708)tgC>tgT	p.C236C	LZTR1_ENST00000479606.1_3'UTR|LZTR1_ENST00000389355.3_Silent_p.C217C	NM_006767.3	NP_006758.2	Q8N653	LZTR1_HUMAN	leucine-zipper-like transcription regulator 1	236					anatomical structure morphogenesis		sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)	42	all_cancers(11;1.83e-25)|all_epithelial(7;9.19e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TGGCTGTGTGCCGGGACAAGA	0.582000													3	28					0	0	0.115264	0	0
SLFN11	91607	broad.mit.edu	37	17	33687335	33687335	+	Silent	SNP	A	A	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr17:33687335A>G	ENST00000394566.1	-	5	1397	c.1125T>C	c.(1123-1125)ccT>ccC	p.P375P	SLFN11_ENST00000308377.4_Silent_p.P375P	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	375						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGCTAAGGGGAGGCCCACTAG	0.388000													9	47					0	0	0.058154	0	0
ZFP82	284406	broad.mit.edu	37	19	36884572	36884572	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr19:36884572T>A	ENST00000392161.3	-	5	912	c.670A>T	c.(670-672)Aaa>Taa	p.K224*	ZFP82_ENST00000392171.1_Nonsense_Mutation_p.K224*	NM_133466.2	NP_597723.1	Q8N141	ZFP82_HUMAN	ZFP82 zinc finger protein	224					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TCATAGAGTTTTTCACCAGAA	0.403000													16	61					0	0	0.160694	0	0
PRICKLE3	4007	broad.mit.edu	37	X	49032614	49032614	+	Splice_Site	SNP	G	G	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:49032614G>T	ENST00000376317.3	-	9	1350	c.1255_splice	c.e9-1	p.A419_splice	PRICKLE3_ENST00000538114.1_Intron|PRICKLE3_ENST00000536904.1_Splice_Site_p.A338_splice|PRICKLE3_ENST00000540849.1_Splice_Site_p.A351_splice	NM_006150.3	NP_006141.2	O43900	PRIC3_HUMAN	prickle homolog 3 (Drosophila)	419				Missing (in Ref. 5; AAB92357).			protein binding|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|skin(2)	22						AGGGCCTGTAGCTGTTAAGGG	0.647000													3	10					0.004672	0.00496122	0.115264	1	0
USH2A	7399	broad.mit.edu	37	1	216108090	216108090	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:216108090C>T	ENST00000366943.2	-	38	7554	c.7168G>A	c.(7168-7170)Gga>Aga	p.G2390R	USH2A_ENST00000307340.3_Missense_Mutation_p.G2390R			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2390	Fibronectin type-III 10.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.G2390R(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTCTCTTCTCCGCTGTACATG	0.343000										HNSCC(13;0.011)			17	24					0	0	0.043863	0	0
CPXM2	119587	broad.mit.edu	37	10	125539747	125539747	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr10:125539747C>T	ENST00000241305.3	-	7	1068	c.914G>A	c.(913-915)cGg>cAg	p.R305Q	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	305					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding	p.R305L(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CATCTCGTTCCGGCGGTGATA	0.443000													19	51					0	0	0.049695	0	0
PMS2CL	441194	broad.mit.edu	37	7	6777427	6777427	+	RNA	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:6777427G>A	ENST00000486256.1	+	0	1554					NR_002217.1																						GAACTTTTCTGAGTTCTTTAG	0.393000													5	19					0	0	0.029380	0	0
ZNF157	7712	broad.mit.edu	37	X	47272631	47272631	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:47272631G>A	ENST00000377073.3	+	4	1245	c.1159G>A	c.(1159-1161)Gaa>Aaa	p.E387K		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	387					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						GAAACCTTACGAATGTAATGA	0.428000													7	71					0	0	0.047766	0	0
MTHFD1L	25902	broad.mit.edu	37	6	151209072	151209072	+	Silent	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:151209072C>T	ENST00000367321.3	+	7	1009	c.735C>T	c.(733-735)tcC>tcT	p.S245S	MTHFD1L_ENST00000367307.4_Silent_p.S245S	NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	245	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		GAAAAGGGTCCATGACAATGA	0.438000													11	33					0	0	0.080935	0	0
DNAJC25	548645	broad.mit.edu	37	9	114411887	114411887	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:114411887G>A	ENST00000313525.3	+	3	700	c.644G>A	c.(643-645)cGt>cAt	p.R215H	DNAJC25-GNG10_ENST00000374294.3_Intron|DNAJC25_ENST00000556107.1_Intron	NM_001015882.2	NP_001015882.2	Q9H1X3	DJC25_HUMAN	DnaJ (Hsp40) homolog, subfamily C , member 25	215					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(2)|lung(1)|skin(4)	8						GAAGAAATTCGTGACGAGGAG	0.393000													3	40					0	0	0.115264	0	0
SEMA3A	10371	broad.mit.edu	37	7	83640399	83640399	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:83640399A>G	ENST00000265362.3	-	9	1248	c.934T>C	c.(934-936)Ttc>Ctc	p.F312L	SEMA3A_ENST00000436949.1_Missense_Mutation_p.F312L	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	312	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						TTCATTAGGAATACATCCTCT	0.303000													5	28					0	0	0.014758	0	0
LOC645166	645166	broad.mit.edu	37	1	148932789	148932789	+	RNA	SNP	G	G	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:148932789G>T	ENST00000539543.1	+	0	45					NR_027355.1																						TCTGCAGACTGCTGGCCAGAC	0.582000													4	99					0.014758	0.0153071	0.014758	1	0
MDN1	23195	broad.mit.edu	37	6	90455080	90455080	+	Missense_Mutation	SNP	C	C	T	rs114853466	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:90455080C>T	ENST00000369393.3	-	29	4205	c.4090G>A	c.(4090-4092)Gtg>Atg	p.V1364M	MDN1_ENST00000428876.1_Missense_Mutation_p.V1364M			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1364					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCAGTCCACACGATATGGCCA	0.433000													9	52					0	0	0.047766	0	0
OR2G6	391211	broad.mit.edu	37	1	248685778	248685778	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:248685778C>G	ENST00000343414.4	+	1	863	c.831C>G	c.(829-831)ttC>ttG	p.F277L		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTTCTCTTTTCTATACCATAG	0.438000													5	92					0	0	0.014758	0	0
PCLO	27445	broad.mit.edu	37	7	82582407	82582407	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:82582407G>A	ENST00000423517.2	-	5	8199	c.7862C>T	c.(7861-7863)tCt>tTt	p.S2621F	PCLO_ENST00000333891.8_Missense_Mutation_p.S2621F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2552					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AGGAACTACAGAAAACACAGG	0.453000													20	109					0	0	0.049695	0	0
CENPC	1060	broad.mit.edu	37	4	68374581	68374581	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:68374581C>A	ENST00000273853.6	-	10	2105	c.1855G>T	c.(1855-1857)Gaa>Taa	p.E619*		NM_001812.2	NP_001803.2			centromere protein C																		TCATCACTTTCCAATGGCTCA	0.368000													18	99					2.35188e-11	2.66228e-11	0.175082	1	0
CTDSPL	10217	broad.mit.edu	37	3	38022323	38022323	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:38022323G>A	ENST00000443503.2	+	7	1003	c.763G>A	c.(763-765)Gtg>Atg	p.V255M	CTDSPL_ENST00000273179.5_Missense_Mutation_p.V266M|CTDSPL_ENST00000310189.3_3'UTR	NM_005808.2	NP_005799.2	O15194	CTDSL_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	266	FCP1 homology.					nucleus	metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|large_intestine(4)|skin(1)	8		Melanoma(1037;0.0122)		KIRC - Kidney renal clear cell carcinoma(284;0.0729)|Kidney(284;0.0902)		GGAGGACGACGTGTACAGCAT	0.617000													6	9					0	0	0.047766	0	0
THSD7B	80731	broad.mit.edu	37	2	137988705	137988705	+	Silent	SNP	C	C	T	rs143921844	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:137988705C>T	ENST00000409968.1	+	8	1993	c.1815C>T	c.(1813-1815)agC>agT	p.S605S	THSD7B_ENST00000413152.2_Silent_p.S574S|THSD7B_ENST00000272643.3_Silent_p.S605S|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		GTGTGCTGAGCGAGTGGACGG	0.512000													16	45					0	0	0.146539	0	0
PMS2CL	441194	broad.mit.edu	37	7	6777402	6777402	+	RNA	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:6777402G>A	ENST00000486256.1	+	0	1529					NR_002217.1																						AAATTAATAAGAAAGTTGTGC	0.368000													5	16					0	0	0.038147	0	0
PREX2	80243	broad.mit.edu	37	8	69129863	69129863	+	Silent	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr8:69129863C>T	ENST00000288368.4	+	38	4894	c.4617C>T	c.(4615-4617)agC>agT	p.S1539S		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1539					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GCACCCTGAGCGTGACGCTGG	0.527000													5	24					0	0	0.021553	0	0
SMG1	23049	broad.mit.edu	37	16	18896866	18896866	+	Silent	SNP	A	A	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr16:18896866A>G	ENST00000446231.2	-	7	1357	c.945T>C	c.(943-945)ttT>ttC	p.F315F	SMG1_ENST00000565224.1_Silent_p.F289F|SMG1_ENST00000389467.3_Silent_p.F315F			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	315	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						AACTCACCCTAAAATTAGTGC	0.428000													26	88					0	0	0.116897	0	0
RAB6B	51560	broad.mit.edu	37	3	133558368	133558368	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:133558368G>A	ENST00000285208.4	-	5	732	c.383C>T	c.(382-384)aCg>aTg	p.T128M	RAB6B_ENST00000469959.1_Intron|RAB6B_ENST00000543906.1_Missense_Mutation_p.T128M|RAB6B_ENST00000486858.1_Missense_Mutation_p.T115M	NM_016577.3	NP_057661.3	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	128					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	11						AGCCAGGTCCGTCTTGTTGCC	0.562000													13	45					0	0	0.119110	0	0
NMUR2	56923	broad.mit.edu	37	5	151784112	151784112	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:151784112T>A	ENST00000255262.3	-	1	728	c.563A>T	c.(562-564)aAg>aTg	p.K188M	NMUR2_ENST00000518933.1_Intron	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	188					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GTAGTGGAACTTGATGCCATG	0.592000													19	69					0	0	0.062417	0	0
KRT38	8687	broad.mit.edu	37	17	39594546	39594546	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr17:39594546G>A	ENST00000246646.3	-	6	1039	c.1040C>T	c.(1039-1041)tCc>tTc	p.S347F		NM_006771.3	NP_006762.3	O76015	KRT38_HUMAN	keratin 38	347	Coil 2.|Rod.					intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	29		Breast(137;0.000496)				TTCACACAGGGAGTTCTGCAG	0.537000													4	31					0	0	0.115264	0	0
ROCK2	9475	broad.mit.edu	37	2	11351926	11351926	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:11351926T>C	ENST00000315872.6	-	18	2532	c.2084A>G	c.(2083-2085)aAa>aGa	p.K695R	ROCK2_ENST00000401753.1_Missense_Mutation_p.K452R	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	695	Interaction with PPP1R12A.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		CTGTATAACTTTTAGTTGGTA	0.348000													3	54					0	0	0.115264	0	0
DNAH11	8701	broad.mit.edu	37	7	21882362	21882362	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:21882362T>G	ENST00000328843.6	+	67	10944	c.10913T>G	c.(10912-10914)cTt>cGt	p.L3638R	DNAH11_ENST00000409508.3_Missense_Mutation_p.L3631R			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3638	AAA 5 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TTGGAGAAACTTAAGGTAAAA	0.433000									Kartagener syndrome				3	15					0	0	0.115264	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30863357	30863357	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:30863357C>T	ENST00000251071.5	-	18	3613	c.2863G>A	c.(2863-2865)Gaa>Aaa	p.E955K	CAPRIN2_ENST00000395805.2_3'UTR|CAPRIN2_ENST00000308433.5_Missense_Mutation_p.E621K|CAPRIN2_ENST00000298892.5_Missense_Mutation_p.E905K|CAPRIN2_ENST00000417045.1_3'UTR	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	955					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TTAAAGGTTTCGTTGTCTCTT	0.478000													50	213					0	0	0.139131	0	0
TRAPPC12	51112	broad.mit.edu	37	2	3428399	3428399	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:3428399A>C	ENST00000324266.5	+	5	1577	c.1382A>C	c.(1381-1383)tAc>tCc	p.Y461S	TRAPPC12_ENST00000469147.1_3'UTR|TRAPPC12_ENST00000382110.2_Missense_Mutation_p.Y461S	NM_016030.5	NP_057114.5	Q8WVT3	TTC15_HUMAN	trafficking protein particle complex 12	461							binding										GATCTTTATTACGAGTACTAC	0.453000													9	29					0	0	0.069234	0	0
DSCAM	1826	broad.mit.edu	37	21	41711173	41711173	+	Silent	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr21:41711173C>T	ENST00000400454.1	-	7	1857	c.1380G>A	c.(1378-1380)acG>acA	p.T460T		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	460	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCCCCTCCGACGTGATCATCT	0.612000													10	40					0	0	0.080935	0	0
FANCG	2189	broad.mit.edu	37	9	35076825	35076825	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:35076825T>A	ENST00000378643.3	-	7	1311	c.820A>T	c.(820-822)Aaa>Taa	p.K274*		NM_004629.1	NP_004620.1	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	274					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|stomach(1)	28			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GATCCCTCTTTCAGGGCTGCA	0.532000			"""Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks					7	78					0	0	0.029380	0	0
DNAH5	1767	broad.mit.edu	37	5	13759048	13759048	+	Silent	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:13759048C>T	ENST00000265104.4	-	61	10430	c.10326G>A	c.(10324-10326)caG>caA	p.Q3442Q		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3442	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCTGCAGATCCTGCATGGCCA	0.547000									Kartagener syndrome				5	150					0	0	0.014758	0	0
ANO5	203859	broad.mit.edu	37	11	22248895	22248895	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:22248895G>C	ENST00000324559.8	+	7	728	c.411G>C	c.(409-411)tgG>tgC	p.W137C		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	137						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ATGCCCCTTGGGAGGTATTAG	0.408000													10	122					0	0	0.093190	0	0
ZNF774	342132	broad.mit.edu	37	15	90904004	90904004	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr15:90904004C>T	ENST00000354377.3	+	4	1127	c.941C>T	c.(940-942)aCg>aTg	p.T314M	ZNF774_ENST00000379090.5_Intron	NM_001004309.2	NP_001004309.2	Q6NX45	ZN774_HUMAN	zinc finger protein 774	314					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(4)|prostate(1)|stomach(1)	14	Melanoma(11;0.00551)|Lung NSC(78;0.0158)|all_lung(78;0.0331)		BRCA - Breast invasive adenocarcinoma(143;0.0224)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CGAACCCACACGGGAGAACGG	0.527000													21	211					0	0	0.062417	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	G	rs121913529		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:25398284C>G	ENST00000311936.3	-	2	226	c.35G>C	c.(34-36)gGt>gCt	p.G12A	KRAS_ENST00000557334.1_Missense_Mutation_p.G12A|KRAS_ENST00000556131.1_Missense_Mutation_p.G12A|KRAS_ENST00000256078.4_Missense_Mutation_p.G12A	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	9					0	0	0.014758	0	0
OR2M7	391196	broad.mit.edu	37	1	248487030	248487030	+	Missense_Mutation	SNP	C	C	T	rs143090101	byFrequency	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:248487030C>T	ENST00000317965.2	-	1	869	c.841G>A	c.(841-843)Gtc>Atc	p.V281I		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V281I(1)		breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGGGAGTGACGATGGTGTAG	0.453000													12	54					0	0	0.080935	0	0
DLX5	1749	broad.mit.edu	37	7	96653608	96653608	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:96653608G>A	ENST00000222598.4	-	1	801	c.328C>T	c.(328-330)Cgc>Tgc	p.R110C	DLX5_ENST00000486603.2_Missense_Mutation_p.R110C|DLX5_ENST00000493764.1_5'UTR	NM_005221.5	NP_005212.1	P56178	DLX5_HUMAN	distal-less homeobox 5	110					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)	20	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					CTTGGGACGCGGTTGTAGGCG	0.637000													3	14					0	0	0.014758	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77327081	77327081	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr16:77327081G>A	ENST00000282849.5	-	20	3499	c.3081C>T	c.(3079-3081)ccC>ccT	p.P1027P		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	1027	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						ACTGGCTCTCGGGGAGGGTTT	0.567000													17	44					0	0	0.175082	0	0
SH2D2A	9047	broad.mit.edu	37	1	156779567	156779567	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:156779567G>A	ENST00000392306.2	-	6	769	c.630C>T	c.(628-630)acC>acT	p.T210T	SH2D2A_ENST00000368199.3_Silent_p.T200T|SH2D2A_ENST00000368198.3_Silent_p.T182T	NM_001161441.1	NP_001154913.1	Q9NP31	SH22A_HUMAN	SH2 domain containing 2A	200	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|large_intestine(2)|lung(15)	18	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTGATTCTTCGGTCCTCAGGG	0.582000													150	338					0	0	0.139131	0	0
NAALAD2	10003	broad.mit.edu	37	11	89896721	89896721	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:89896721C>A	ENST00000534061.1	+	11	1444	c.1214C>A	c.(1213-1215)aCt>aAt	p.T405N	NAALAD2_ENST00000375944.3_Intron|NAALAD2_ENST00000321955.4_Missense_Mutation_p.T372N|NAALAD2_ENST00000525171.1_Missense_Mutation_p.T312N	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	405	NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CCTAGAAGAACTATCATTTTT	0.368000													7	33					1.12685e-05	1.22579e-05	0.047766	1	0
DAW1	164781	broad.mit.edu	37	2	228758628	228758628	+	Silent	SNP	T	T	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:228758628T>G	ENST00000373666.2	+	5	1071	c.435T>G	c.(433-435)ccT>ccG	p.P145P	DAW1_ENST00000309931.2_Silent_p.P145P|DAW1_ENST00000472604.1_3'UTR|DAW1_ENST00000545118.1_Silent_p.P130P					dynein assembly factor with WDR repeat domains 1																		TCAACAATCCTTACGGGTGTG	0.458000													3	8					0	0	0.115264	0	0
LINC00264	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	G	A	rs138111133	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr10:26880266G>A	ENST00000412114.1	+	0	501					NR_026793.1																						ACCAAGCCCAGTGGACAGATG	0.443000													4	48					0	0	0.150653	0	0
LINC00969	440993	broad.mit.edu	37	3	195410627	195410627	+	RNA	SNP	A	A	G	rs6583272	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:195410627A>G	ENST00000445430.1	+	0	1824																											CCTCAGGTGCAGATTGATGAG	0.473000													4	31					0	0	0.021553	0	0
TTN	7273	broad.mit.edu	37	2	179449471	179449471	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:179449471G>A	ENST00000589042.1	-	310	65121	c.64897C>T	c.(64897-64899)Cgg>Tgg	p.R21633W	TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R19992W|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R19065W|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R12760W|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R12568W|TTN_ENST00000359218.5_Missense_Mutation_p.R12693W	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19992	Fibronectin type-III 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACGGACCCGGAAGATGTAC	0.493000													5	207					0	0	0.029380	0	0
MFAP3L	9848	broad.mit.edu	37	4	170913056	170913056	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:170913056C>T	ENST00000361618.3	-	3	1010	c.703G>A	c.(703-705)Gaa>Aaa	p.E235K	RP11-6E9.4_ENST00000508955.1_RNA|MFAP3L_ENST00000393704.3_Missense_Mutation_p.E132K	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	235						integral to membrane|plasma membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		GCAAGCTCTTCGATGTAGCGG	0.547000													3	34					0	0	0.047766	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973245	46973245	+	Missense_Mutation	SNP	C	C	T	rs144904720	byFrequency	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr19:46973245C>T	ENST00000313683.10	-	2	1353	c.1048G>A	c.(1048-1050)Gtg>Atg	p.V350M	PNMAL1_ENST00000438932.2_Missense_Mutation_p.V350M|PNMAL1_ENST00000602246.1_Intron	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	350										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ACCCAGGCCACGGCCTTCTTC	0.597000													50	143					0	0	0.139131	0	0
POLR3E	55718	broad.mit.edu	37	16	22334242	22334242	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr16:22334242G>A	ENST00000299853.5	+	14	1225	c.1058G>A	c.(1057-1059)cGa>cAa	p.R353Q	POLR3E_ENST00000564209.1_Missense_Mutation_p.R353Q|POLR3E_ENST00000359210.4_Missense_Mutation_p.R353Q|POLR3E_ENST00000418581.2_Missense_Mutation_p.R317Q	NM_001258033.1|NM_001258035.1|NM_018119.3	NP_001244962.1|NP_001244964.1|NP_060589.1	Q9NVU0	RPC5_HUMAN	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	353					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.012)		TGCAGGGGCCGAGACTTCGTT	0.637000													3	9					0	0	0.115264	0	0
NLRP5	126206	broad.mit.edu	37	19	56538691	56538691	+	Silent	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr19:56538691C>T	ENST00000390649.3	+	7	1092	c.1092C>T	c.(1090-1092)ttC>ttT	p.F364F		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	364	NACHT.					mitochondrion|nucleolus	ATP binding	p.F364F(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TTGACGGTTTCGATGACCTGG	0.552000													5	21					0	0	0.014758	0	0
CP	1356	broad.mit.edu	37	3	148925350	148925350	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:148925350T>A	ENST00000264613.6	-	5	1098	c.836A>T	c.(835-837)gAc>gTc	p.D279V		NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	279	F5/8 type A 1.|Plastocyanin-like 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	TTTTACTCTGTCTTCAGCACA	0.433000													13	72					0	0	0.105934	0	0
UNC79	57578	broad.mit.edu	37	14	94044289	94044289	+	Silent	SNP	G	G	A	rs149686132		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr14:94044289G>A	ENST00000553484.1	+	18	2467	c.2313G>A	c.(2311-2313)ccG>ccA	p.P771P	UNC79_ENST00000393151.2_Silent_p.P771P|UNC79_ENST00000555664.1_Silent_p.P771P|UNC79_ENST00000256339.4_Silent_p.P594P			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	771						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TGCGTAGTCCGTTTCGTAGCC	0.438000													14	127					0	0	0.132662	0	0
KRT38	8687	broad.mit.edu	37	17	39594556	39594556	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr17:39594556G>A	ENST00000246646.3	-	6	1029	c.1030C>T	c.(1030-1032)Ctg>Ttg	p.L344L		NM_006771.3	NP_006762.3	O76015	KRT38_HUMAN	keratin 38	344	Coil 2.|Rod.					intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	29		Breast(137;0.000496)				GAGTTCTGCAGACAGTCCTTC	0.527000													5	35					0	0	0.150653	0	0
PRSS35	167681	broad.mit.edu	37	6	84233872	84233872	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:84233872C>T	ENST00000536636.1	+	3	1057	c.712C>T	c.(712-714)Cgg>Tgg	p.R238W	PRSS35_ENST00000369700.3_Missense_Mutation_p.R238W	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	238	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity	p.R238W(1)		breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		AAAATCTGGCCGGGGTCAGAG	0.587000													16	32					0	0	0.043863	0	0
LPHN2	23266	broad.mit.edu	37	1	82408983	82408983	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:82408983C>T	ENST00000370728.1	+	8	1373	c.728C>T	c.(727-729)gCc>gTc	p.A243V	LPHN2_ENST00000370723.1_Missense_Mutation_p.A243V|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370730.1_Missense_Mutation_p.A243V|LPHN2_ENST00000271029.4_Missense_Mutation_p.A243V|LPHN2_ENST00000370721.1_Missense_Mutation_p.A247V|LPHN2_ENST00000394879.1_Missense_Mutation_p.A243V|LPHN2_ENST00000370713.1_Missense_Mutation_p.A243V|LPHN2_ENST00000319517.6_Missense_Mutation_p.A243V|LPHN2_ENST00000370715.1_Missense_Mutation_p.A243V|LPHN2_ENST00000370725.1_Missense_Mutation_p.A243V|LPHN2_ENST00000335786.5_Missense_Mutation_p.A243V|LPHN2_ENST00000370717.2_Missense_Mutation_p.A243V|LPHN2_ENST00000359929.3_Missense_Mutation_p.A243V|LPHN2_ENST00000370727.1_Missense_Mutation_p.A243V			O95490	LPHN2_HUMAN	latrophilin 2	243	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		AGTGGCGAGGCCATAATTAAC	0.398000													10	49					0	0	0.058154	0	0
NETO1	81832	broad.mit.edu	37	18	70526282	70526282	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr18:70526282T>G	ENST00000327305.6	-	4	905	c.248A>C	c.(247-249)tAc>tCc	p.Y83S	NETO1_ENST00000397929.1_Missense_Mutation_p.Y82S|NETO1_ENST00000583169.1_Missense_Mutation_p.Y83S|NETO1_ENST00000580049.1_5'UTR|NETO1_ENST00000299430.2_Missense_Mutation_p.Y82S	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	83	CUB 1.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		TTCATCAAAGTAAAGTTCAAT	0.378000													11	27					0	0	0.093190	0	0
PRDM2	7799	broad.mit.edu	37	1	14105149	14105149	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:14105149G>A	ENST00000235372.7	+	8	1715	c.859G>A	c.(859-861)Gat>Aat	p.D287N	PRDM2_ENST00000413440.1_Missense_Mutation_p.D86N|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000311066.5_Missense_Mutation_p.D287N|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000343137.4_Missense_Mutation_p.D86N|PRDM2_ENST00000376048.5_Intron	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	287	Asp/Glu-rich (acidic).			EDEEEEEDDDDDELEDEG -> VGGGGGVVVVVSWKARGE (in Ref. 4; AAA87023).		Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		tgatgatgatgatgagttgga	0.463000													24	58					0	0	0.076483	0	0
CBLB	868	broad.mit.edu	37	3	105456067	105456067	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:105456067T>C	ENST00000264122.4	-	8	1340	c.1019A>G	c.(1018-1020)gAt>gGt	p.D340G	CBLB_ENST00000405772.1_Missense_Mutation_p.D340G|CBLB_ENST00000545639.1_3'UTR|CBLB_ENST00000394027.3_Missense_Mutation_p.D362G|CBLB_ENST00000403724.1_Missense_Mutation_p.D340G	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	340	Cbl-PTB.|SH2-like.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						TCCAGTTAAATCAGGATTATA	0.279000			Mis S		AML								6	10					0	0	0.029380	0	0
TP53	7157	broad.mit.edu	37	17	7577097	7577097	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr17:7577097C>T	ENST00000420246.2	-	8	973	c.841G>A	c.(841-843)Gac>Aac	p.D281N	TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Missense_Mutation_p.D281N|TP53_ENST00000269305.4_Missense_Mutation_p.D281N|TP53_ENST00000359597.4_Missense_Mutation_p.D281N|TP53_ENST00000445888.2_Missense_Mutation_p.D281N	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	281	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		D -> A (in sporadic cancers; somatic mutation).|D -> E (in sporadic cancers; somatic mutation).|D -> G (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|D -> H (in sporadic cancers; somatic mutation).|D -> N (in LFS; germline mutation and in sporadic cancers; somatic mutation).|D -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|D -> V (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|D -> Y (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.D281N(25)|p.D281H(19)|p.D281Y(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.D281>AGPY(2)|p.A276_R283delACPGRDRR(1)|p.D281R(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.D281_R282delDR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGCGCCGGTCTCTCCCAGGA	0.547000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			11	22					0	0	0.069234	0	0
FCRL3	115352	broad.mit.edu	37	1	157650553	157650553	+	Silent	SNP	A	A	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:157650553A>G	ENST00000368184.3	-	13	2256	c.1965T>C	c.(1963-1965)ccT>ccC	p.P655P	FCRL3_ENST00000368186.5_Silent_p.P655P|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	655						integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					TGCTATCTCCAGGATTTACTG	0.418000													11	81					0	0	0.080935	0	0
CACNA1S	779	broad.mit.edu	37	1	201038623	201038623	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:201038623G>A	ENST00000362061.3	-	18	2693	c.2467C>T	c.(2467-2469)Cgg>Tgg	p.R823W	CACNA1S_ENST00000367338.3_Missense_Mutation_p.R823W	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	823					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GAATCAGCCCGGATGGGGTCT	0.597000													10	8					0	0	0.080935	0	0
PSD	5662	broad.mit.edu	37	10	104173681	104173681	+	Silent	SNP	C	C	T	rs140240917		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr10:104173681C>T	ENST00000020673.5	-	5	1924	c.1398G>A	c.(1396-1398)ccG>ccA	p.P466P	PSD_ENST00000406432.1_Silent_p.P466P	NM_001270966.1|NM_002779.3	NP_001257895.1|NP_002770.3	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	466	Pro-rich.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|endometrium(2)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		TACCAGAATCCGGTTCAAGAG	0.672000													3	20					0	0	0.115264	0	0
KIAA1109	84162	broad.mit.edu	37	4	123192465	123192465	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:123192465A>T	ENST00000264501.4	+	47	8159	c.7786A>T	c.(7786-7788)Aga>Tga	p.R2596*	KIAA1109_ENST00000455637.1_Nonsense_Mutation_p.R2596*|KIAA1109_ENST00000388738.3_Nonsense_Mutation_p.R2596*			Q2LD37	K1109_HUMAN	KIAA1109	2596					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TAAACTTAGCAGATATACAGC	0.413000													6	68					0	0	0.021553	0	0
CPPED1	55313	broad.mit.edu	37	16	12758835	12758835	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr16:12758835C>T	ENST00000381774.4	-	4	1093	c.853G>A	c.(853-855)Gcc>Acc	p.A285T	CPPED1_ENST00000261660.4_Missense_Mutation_p.R111H|CPPED1_ENST00000433677.2_Missense_Mutation_p.A143T	NM_018340.2	NP_060810.2	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain containing 1	285							hydrolase activity|metal ion binding	p.A285T(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|urinary_tract(1)	18						ATTTTCTCGGCGGTGACCACC	0.522000													6	14					0	0	0.029380	0	0
MAGI1	9223	broad.mit.edu	37	3	65415696	65415696	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:65415696A>C	ENST00000330909.8	-	12	1665	c.1666T>G	c.(1666-1668)Tat>Gat	p.Y556D	MAGI1_ENST00000483466.1_Missense_Mutation_p.Y556D|MAGI1_ENST00000497477.2_Missense_Mutation_p.Y556D|MAGI1_ENST00000402939.2_Missense_Mutation_p.Y556D	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	556					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GGCAATGGATAACCTCGGCAG	0.463000													7	42					0	0	0.029380	0	0
TBX15	6913	broad.mit.edu	37	1	119467377	119467377	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:119467377T>A	ENST00000369429.3	-	4	594	c.585A>T	c.(583-585)agA>agT	p.R195S	TBX15_ENST00000207157.3_Missense_Mutation_p.R89S			Q96SF7	TBX15_HUMAN	T-box 15	195						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GTATATAAACTCTTGGGGGCA	0.453000													48	202					0	0	0.139131	0	0
C2orf71	388939	broad.mit.edu	37	2	29296670	29296670	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:29296670G>A	ENST00000331664.5	-	1	457	c.458C>T	c.(457-459)aCg>aTg	p.T153M		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	153					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TGTGCTTGACGTGTGACATTT	0.517000													13	35					0	0	0.093190	0	0
PEX11B	8799	broad.mit.edu	37	1	145522602	145522602	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:145522602C>T	ENST00000369306.3	+	4	612	c.463C>T	c.(463-465)Cgg>Tgg	p.R155W	PEX11B_ENST00000537888.1_Missense_Mutation_p.R141W	NM_003846.2	NP_003837.1	O96011	PX11B_HUMAN	peroxisomal biogenesis factor 11 beta	155					peroxisome fission|signal transduction	integral to peroxisomal membrane	protein binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGCTTGTAGCCGGCGACTGAA	0.527000													47	62					0	0	0.139131	0	0
PPT2	9374	broad.mit.edu	37	6	32130686	32130686	+	Missense_Mutation	SNP	C	C	T	rs144778647	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:32130686C>T	ENST00000324816.6	+	9	1436	c.868C>T	c.(868-870)Cgt>Tgt	p.R290C	PPT2_ENST00000361568.2_Missense_Mutation_p.R296C|PPT2_ENST00000395523.1_Missense_Mutation_p.R290C|PPT2-EGFL8_ENST00000422437.1_Intron|PPT2_ENST00000375137.2_Missense_Mutation_p.R290C|PPT2_ENST00000445576.2_Intron|PPT2-EGFL8_ENST00000453656.2_Intron|PPT2_ENST00000375143.2_Missense_Mutation_p.R290C|PPT2_ENST00000437001.2_Intron			Q9UMR5	PPT2_HUMAN	palmitoyl-protein thioesterase 2	290					protein modification process	lysosome	palmitoyl-(protein) hydrolase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|prostate(1)|urinary_tract(1)	17						GCACTCCAACCGTACCCTTTA	0.552000													31	155					0	0	0.183431	0	0
MYO1F	4542	broad.mit.edu	37	19	8587292	8587292	+	Silent	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr19:8587292G>A	ENST00000338257.8	-	27	3456	c.3189C>T	c.(3187-3189)aaC>aaT	p.N1063N		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	1063	SH3.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CCTCGTTCACGTTGAAGCTCA	0.622000													3	25					0	0	0.150653	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104961395	104961395	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:104961395G>A	ENST00000372582.1	+	7	1564	c.808G>A	c.(808-810)Gga>Aga	p.G270R	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.G270R	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	270	Ig-like C2-type 3.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AGCATTCTTCGGATTCAGTGG	0.438000													39	81					0	0	0.092188	0	0
CFHR3	10878	broad.mit.edu	37	1	196759231	196759231	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:196759231T>A	ENST00000367425.4	+	5	762	c.670T>A	c.(670-672)Ttt>Att	p.F224I	CFHR3_ENST00000391985.3_Missense_Mutation_p.F163I	NM_021023.5	NP_066303.2			complement factor H-related 3											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18						TACCACCTCCTTTCTACTAAA	0.388000													14	41					0	0	0.108266	0	0
CMYA5	202333	broad.mit.edu	37	5	79086882	79086882	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:79086882C>T	ENST00000446378.2	+	11	11810	c.11779C>T	c.(11779-11781)Cgg>Tgg	p.R3927W	CTC-431G16.2_ENST00000421252.2_RNA	NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3927	B30.2/SPRY.		R -> Q (in dbSNP:rs1129770).			perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TGAGAGGAGACGGCTGACGGA	0.517000													3	21					0	0	0.115264	0	0
MXRA5	25878	broad.mit.edu	37	X	3241359	3241359	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:3241359T>G	ENST00000217939.6	-	5	2521	c.2367A>C	c.(2365-2367)aaA>aaC	p.K789N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	789						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TCCCACGGACTTTGGCTAAAA	0.458000													10	131					0	0	0.069234	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459873	66459873	+	RNA	SNP	C	C	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:66459873C>T	ENST00000424345.1	+	0	133																											ggtgttgatgctagtagatgt	0.373000													3	38					0	0	0.150653	0	0
SCMH1	22955	broad.mit.edu	37	1	41579129	41579129	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:41579129G>A	ENST00000402904.2	-	8	909	c.541C>T	c.(541-543)Cct>Tct	p.P181S	SCMH1_ENST00000397171.2_Missense_Mutation_p.P120S|SCMH1_ENST00000361191.5_Missense_Mutation_p.P120S|SCMH1_ENST00000397174.2_Missense_Mutation_p.P161S|SCMH1_ENST00000361705.3_Missense_Mutation_p.P134S|SCMH1_ENST00000456518.2_Intron|SCMH1_ENST00000372597.1_Missense_Mutation_p.P134S|SCMH1_ENST00000372595.1_Missense_Mutation_p.P120S|SCMH1_ENST00000372596.1_Missense_Mutation_p.P120S|SCMH1_ENST00000337495.5_Missense_Mutation_p.P191S|SCMH1_ENST00000326197.7_Missense_Mutation_p.P181S	NM_001031694.2	NP_001026864.1	Q96GD3	SCMH1_HUMAN	sex comb on midleg homolog 1 (Drosophila)	181					anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(2)|pancreas(2)|upper_aerodigestive_tract(1)	15	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				ATGAAATGAGGGTTCTTCCTG	0.512000													11	29					0	0	0.069234	0	0
ERCC6L	54821	broad.mit.edu	37	X	71425005	71425005	+	Silent	SNP	T	T	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:71425005T>C	ENST00000373657.1	-	3	3845	c.3243A>G	c.(3241-3243)gtA>gtG	p.V1081V	PIN4_ENST00000423432.2_Intron|ERCC6L_ENST00000334463.3_Silent_p.V1204V			Q2NKX8	ERC6L_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	1204					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			breast(2)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(9)|lung(9)|ovary(3)|skin(1)	38	Renal(35;0.156)					TTCCACGCTTTACAAGAGTCT	0.463000													11	62					0	0	0.069234	0	0
KCNT2	343450	broad.mit.edu	37	1	196227504	196227504	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:196227504G>A	ENST00000367433.5	-	25	3060	c.2959C>T	c.(2959-2961)Cgg>Tgg	p.R987W	KCNT2_ENST00000451324.2_3'UTR|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000294725.8_Missense_Mutation_p.R1011W|KCNT2_ENST00000367431.4_Missense_Mutation_p.R945W			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1011						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CTTTTTCTCCGCAGCAAGGGA	0.512000													7	28					0	0	0.038147	0	0
LOC284632	284632	broad.mit.edu	37	1	24533206	24533206	+	RNA	DEL	G	G	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:24533206delG	ENST00000439059.2	+	0	288					NR_027087.2																						CTAGAGGCCAGGGCAGAAAGC	0.587													2	4	---	---	---	---					
SLC16A1-AS1	100506392	broad.mit.edu	37	1	113520589	113520589	+	RNA	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:113520589delA	ENST00000435800.2	+	0	627																											acttcgtctcaaaaaaaaaaa	0.552													2	4	---	---	---	---					
RP11-640M9.2	0	broad.mit.edu	37	1	144595647	144595647	+	RNA	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:144595647delT	ENST00000419820.1	+	0	439																											aatctttttatccagttttca	0.308													2	4	---	---	---	---					
RP11-640M9.2	0	broad.mit.edu	37	1	144597983	144597991	+	RNA	DEL	CAGATAGAC	CAGATAGAC	-	rs111294330		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:144597983_144597991delCAGATAGAC	ENST00000419820.1	+	0	439																											TATACGTGTACAGATAGACCAGATAGACC	0.402													4	4	---	---	---	---					
PDE4DIP	9659	broad.mit.edu	37	1	145014186	145014187	+	Frame_Shift_Ins	INS	-	-	A	rs142142861		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:145014186_145014187insA	ENST00000493130.2	-	4	516_517	c.355_356insT	c.(355-357)accfs	p.T119fs	PDE4DIP_ENST00000369348.3_Intron|PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000530740.1_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCCAAAAGGTGAAAAAAAAAAA	0.510			T	PDGFRB	MPD								2	4	---	---	---	---					
SEC22B	9554	broad.mit.edu	37	1	145107771	145107774	+	RNA	DEL	AAAT	AAAT	-	rs3977178		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:145107771_145107774delAAAT	ENST00000453618.1	+	0	512							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										agcaaaaaacaaataaccccattt	0.309													4	6	---	---	---	---					
LOC101928565	101928565	broad.mit.edu	37	1	168435505	168435506	+	RNA	INS	-	-	T	rs55921453	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:168435505_168435506insT	ENST00000422253.1	-	0	359																											AGGAAGGGGAATGCTTTTCATT	0.441													4	4	---	---	---	---					
RP11-323I1.1	0	broad.mit.edu	37	1	213923251	213923252	+	RNA	INS	-	-	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr1:213923251_213923252insG	ENST00000456240.1	+	0	143																											CAGGAAGGTTAGCGGGGAACAT	0.455													2	4	---	---	---	---					
AC105393.1	0	broad.mit.edu	37	2	409412	409412	+	RNA	DEL	A	A	-	rs11328094		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:409412delA	ENST00000431911.1	+	0	186																											aaacaacaacaaaaaaaaCCA	0.512													5	2	---	---	---	---					
LINC01115	339822	broad.mit.edu	37	2	808217	808217	+	RNA	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:808217delT	ENST00000414556.1	-	0	548					NR_033880.1																						tttcttgaccttgtgatctgc	0.448													2	4	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12208946	12208947	+	RNA	INS	-	-	A	rs34909473	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:12208946_12208947insA	ENST00000412294.1	+	0	197																											tccccgaacttaaaaaaaaaag	0.431													6	1	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12439880	12439881	+	RNA	DEL	AG	AG	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:12439880_12439881delAG	ENST00000412294.1	+	0	315																											gaggtgagacagagagagagag	0.436													3	4	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22727578	22727579	+	RNA	INS	-	-	AGAG			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:22727578_22727579insAGAG	ENST00000450551.1	-	0	70																											gacagtgagtcagagagagaca	0.366													2	4	---	---	---	---					
LOC100505774	100505774	broad.mit.edu	37	2	28951499	28951501	+	RNA	DEL	AAC	AAC	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:28951499_28951501delAAC	ENST00000452212.1	-	0	179				AC097724.3_ENST00000444501.1_RNA|AC097724.3_ENST00000428036.1_RNA																							tgtctcgaaaaacaacaacaaca	0.438													4	4	---	---	---	---					
AC009229.5	0	broad.mit.edu	37	2	38443256	38443261	+	RNA	DEL	TGTTTG	TGTTTG	-	rs74869664		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:38443256_38443261delTGTTTG	ENST00000450854.1	-	0	533																											ggtgtttttttgtttgtgtttgtgtt	0.374													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51425495	51425495	+	RNA	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:51425495delA	ENST00000440698.1	+	0	514																											AGCAGGTATCAAGCACAACAT	0.428													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51641525	51641526	+	RNA	INS	-	-	GT			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:51641525_51641526insGT	ENST00000440698.1	+	0	694																											AATATGCTAAAGTGTGTGTGTG	0.347													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51644170	51644171	+	RNA	INS	-	-	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:51644170_51644171insC	ENST00000440698.1	+	0	694																											gtcataagacaccccccattcc	0.406													2	4	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	59656451	59656451	+	RNA	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:59656451delT	ENST00000606382.1	-	0	433																											acgatctgaattttttttttt	0.423													3	5	---	---	---	---					
AC084193.1	0	broad.mit.edu	37	2	80946485	80946485	+	RNA	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:80946485delA	ENST00000450290.1	-	0	468																											tagtggttctaaccatcccca	0.478													2	4	---	---	---	---					
LINC00152	112597	broad.mit.edu	37	2	87754980	87754981	+	RNA	INS	-	-	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:87754980_87754981insT	ENST00000409054.1	+	0	94_95					NR_015395.1																						AGGTGTGCGCCTTTTTTTTTTT	0.431													2	4	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	164876099	164876099	+	RNA	DEL	C	C	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:164876099delC	ENST00000429636.1	-	0	196																											ttattcctcacccccctccca	0.428													3	3	---	---	---	---					
SCN9A	6335	broad.mit.edu	37	2	167168127	167168127	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:167168127delG	ENST00000375387.4	-	2	480	c.140delC	c.(139-141)cafs	p.P47fs	SCN9A_ENST00000409672.1_Frame_Shift_Del_p.P47fs|SCN9A_ENST00000303354.6_Frame_Shift_Del_p.P47fs|SCN9A_ENST00000409435.1_Frame_Shift_Del_p.P47fs			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	47						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	GCTTGGCTTTGGGGCTTCTTC	0.488													27	120	---	---	---	---					
FSIP2	401024	broad.mit.edu	37	2	186665039	186665039	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:186665039delA	ENST00000343098.5	+	17	11273	c.11273delA	c.(11272-11274)cafs	p.Q3758fs	FSIP2_ENST00000424728.1_Frame_Shift_Del_p.Q3669fs	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						CAACTTTTTCAAAAAAATAAG	0.323													2	4	---	---	---	---					
AC018717.1	0	broad.mit.edu	37	2	199885954	199885955	+	RNA	INS	-	-	GT	rs77536519		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:199885954_199885955insGT	ENST00000456031.1	-	0	114																											tgtgtgtgtgcgtgtgtgtgtg	0.450													2	4	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217816106	217816107	+	RNA	INS	-	-	A	rs143950283	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr2:217816106_217816107insA	ENST00000447289.1	+	0	510				AC007563.5_ENST00000607591.1_RNA																							cattctttttttggctgcatag	0.351													5	3	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18933610	18933611	+	RNA	DEL	CT	CT	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:18933610_18933611delCT	ENST00000425799.2	+	0	463																											ctctccctcgctctctctctct	0.465													2	4	---	---	---	---					
AC018359.1	0	broad.mit.edu	37	3	34295726	34295737	+	RNA	DEL	AAAAAAAAAAAA	AAAAAAAAAAAA	-	rs68057677		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:34295726_34295737delAAAAAAAAAAAA	ENST00000424786.1	+	0	159				AC123023.1_ENST00000455974.1_lincRNA																							aaactcctttaaaaaaaaaaaaaaaaaaaaaa	0.401													2	4	---	---	---	---					
RP11-719N22.2	0	broad.mit.edu	37	3	59458472	59458472	+	RNA	DEL	G	G	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:59458472delG	ENST00000486137.1	-	0	287																											TTCATTCACTGGGGGAAGAAA	0.423													2	4	---	---	---	---					
AC136289.1	0	broad.mit.edu	37	3	63779849	63779850	+	RNA	DEL	AC	AC	-	rs34728435		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:63779849_63779850delAC	ENST00000443346.1	-	0	622																											acacacacatacacacacacac	0.455													2	4	---	---	---	---					
SUCLG2-AS1	101927111	broad.mit.edu	37	3	67991797	67991798	+	RNA	INS	-	-	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:67991797_67991798insC	ENST00000482677.1	+	0	1653																											ttcttctgcctcccccccttct	0.465													3	5	---	---	---	---					
RP11-190P13.2	0	broad.mit.edu	37	3	114974578	114974578	+	RNA	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:114974578delA	ENST00000459855.1	+	0	115																											cggaaaacccaaaaggccaga	0.483													2	4	---	---	---	---					
LOC101927123	101927123	broad.mit.edu	37	3	127101867	127101867	+	RNA	DEL	G	G	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr3:127101867delG	ENST00000488425.1	-	0	225																											cctaaggcaaggggtgctatt	0.527													2	4	---	---	---	---					
CTBP1-AS2	92070	broad.mit.edu	37	4	1262349	1262350	+	RNA	INS	-	-	TG	rs141580004	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:1262349_1262350insTG	ENST00000578730.1	+	0	2372																											gatgttagctctgtgtgtgtgt	0.490													5	2	---	---	---	---					
LOC101929095	101929095	broad.mit.edu	37	4	15184306	15184307	+	RNA	INS	-	-	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:15184306_15184307insG	ENST00000502344.1	-	0	154				RP11-665G4.1_ENST00000513384.1_RNA																							aaacccagggtggggggcacag	0.505													2	4	---	---	---	---					
RP11-227F19.1	0	broad.mit.edu	37	4	41825720	41825720	+	RNA	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:41825720delA	ENST00000508038.1	+	0	671																											actctgtctcaaaaaaaaaaa	0.403													2	4	---	---	---	---					
IGFBP7-AS1	255130	broad.mit.edu	37	4	58053425	58053426	+	RNA	INS	-	-	AC	rs112034412	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:58053425_58053426insAC	ENST00000499667.2	+	0	209				RP11-12A1.1_ENST00000508328.1_RNA|RP11-12A1.1_ENST00000515865.1_RNA	NR_034081.1																						aagaattcagaacacacacaca	0.366													3	4	---	---	---	---					
RP11-506N2.1	0	broad.mit.edu	37	4	59812179	59812180	+	RNA	INS	-	-	T	rs111536593	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:59812179_59812180insT	ENST00000513551.1	-	0	236																											caaattcattgtttttttttta	0.337													2	4	---	---	---	---					
RPL34-AS1	285456	broad.mit.edu	37	4	109467732	109467733	+	RNA	INS	-	-	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:109467732_109467733insG	ENST00000507248.1	-	0	890					NR_026968.1																						TTGAACAGCTTGGGGGTTGCTG	0.446													2	4	---	---	---	---					
LINC01378	103689918	broad.mit.edu	37	4	118583625	118583626	+	RNA	INS	-	-	A	rs138494530	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:118583625_118583626insA	ENST00000422145.3	+	0	263																											ccatcattcccaaaaaaacatg	0.322													3	4	---	---	---	---					
RP11-427M20.1	0	broad.mit.edu	37	4	134818162	134818163	+	RNA	INS	-	-	A	rs10717687		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:134818162_134818163insA	ENST00000507844.1	-	0	223																											ggagagaagagaaaaaaaaaaa	0.381													2	4	---	---	---	---					
DCHS2	54798	broad.mit.edu	37	4	155244402	155244405	+	Frame_Shift_Del	DEL	TTTG	TTTG	-	rs112727159		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr4:155244402_155244405delTTTG	ENST00000339452.1	-	8	4455_4458	c.4095_4098delCAAA	c.(4093-4098)aafs	p.NK1365fs	DCHS2_ENST00000357232.3_Intron	NM_001142552.1	NP_001136024.1	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1234	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		aggtCAGGATtttgtttgtttgtt	0.377													3	4	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21544716	21544717	+	RNA	DEL	AT	AT	-	rs145084669		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:21544716_21544717delAT	ENST00000607545.1	+	0	314					NR_027026.1																						GACCAGAACAATATAGTACAAT	0.366													3	3	---	---	---	---					
RP11-184E9.1	0	broad.mit.edu	37	5	25214763	25214764	+	RNA	DEL	AC	AC	-	rs3857316		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:25214763_25214764delAC	ENST00000502100.2	+	0	352																											gcttgcagatacacacacacac	0.401													2	4	---	---	---	---					
CTD-2023N9.1	0	broad.mit.edu	37	5	56737960	56737961	+	RNA	DEL	TG	TG	-	rs10586343		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:56737960_56737961delTG	ENST00000506106.1	+	0	119																											TTTGCtgtgctgtgtgtgtgtg	0.406													2	4	---	---	---	---					
LINC01331	104310351	broad.mit.edu	37	5	73719218	73719221	+	RNA	DEL	AAAG	AAAG	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:73719218_73719221delAAAG	ENST00000507781.1	-	0	422																											AAAGAAAGACaaagaaagaaagaa	0.412													3	3	---	---	---	---					
CTC-498M16.4	0	broad.mit.edu	37	5	87787803	87787803	+	RNA	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:87787803delA	ENST00000504034.2	-	0	25																											TTCCCTCTGGAAAAAAAAAAA	0.348													2	4	---	---	---	---					
CTD-2007H13.3	0	broad.mit.edu	37	5	98290528	98290528	+	RNA	DEL	C	C	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:98290528delC	ENST00000513175.1	+	0	141																											GTCTGTCCTTCATTGACTGCC	0.517													2	4	---	---	---	---					
APC	324	broad.mit.edu	37	5	112175752	112175752	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:112175752delT	ENST00000457016.1	+	16	4841	c.4461delT	c.(4459-4461)acfs	p.T1487fs	APC_ENST00000257430.4_Frame_Shift_Del_p.T1487fs|APC_ENST00000508376.2_Frame_Shift_Del_p.T1487fs|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	1487	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.T1487fs*17(10)|p.L1488fs*19(7)|p.L1488fs*26(5)|p.L1488fs*18(1)|p.?(1)|p.K1454fs*3(1)|p.T1487fs*25(1)|p.T1487T(1)|p.K1192fs*3(1)|p.T1487fs*23(1)|p.L1488fs*20(1)|p.L1488fs*21(1)|p.L1488fs*23(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ATGCTGATACTTTATTACATT	0.443		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			14	48	---	---	---	---					
LOC102546294	102546294	broad.mit.edu	37	5	147685319	147685320	+	RNA	DEL	TG	TG	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:147685319_147685320delTG	ENST00000501695.3	-	0	591																											AGCTGGGAGCtgtgtgtgtgtg	0.455													2	4	---	---	---	---					
LINC01411	101928176	broad.mit.edu	37	5	173830194	173830194	+	RNA	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr5:173830194delT	ENST00000510234.1	+	0	82																											Ttttcttttcttttttttttt	0.468													3	3	---	---	---	---					
LY86-AS1	285780	broad.mit.edu	37	6	6507756	6507759	+	RNA	DEL	AAGG	AAGG	-	rs71732744		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:6507756_6507759delAAGG	ENST00000435641.1	-	0	482				LY86-AS1_ENST00000429345.1_RNA|LY86-AS1_ENST00000447858.1_RNA																							aggagagagaaaggaaggaaggaa	0.348													3	5	---	---	---	---					
RP11-716O23.2	0	broad.mit.edu	37	6	11491237	11491238	+	RNA	DEL	TA	TA	-	rs59042046		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:11491237_11491238delTA	ENST00000423149.1	+	0	417																											tgtgtgtgtctatgtgcgtgca	0.485													5	5	---	---	---	---					
TDRG1	732253	broad.mit.edu	37	6	40314879	40314879	+	RNA	DEL	C	C	-	rs66692453		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:40314879delC	ENST00000451810.1	+	0	313				TDRG1_ENST00000448559.1_RNA																							TAGACCTGATCCCCCACATGA	0.527													9	3	---	---	---	---					
LOC101927082	101927082	broad.mit.edu	37	6	51476169	51476170	+	RNA	INS	-	-	A	rs140463758		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:51476169_51476170insA	ENST00000589278.1	+	0	731				RP3-335N17.2_ENST00000454361.1_RNA																							aagacttggtcaaaaaaaaaaa	0.540													4	3	---	---	---	---					
LOC101928307	101928307	broad.mit.edu	37	6	69344215	69344221	+	RNA	DEL	CCTTTTT	CCTTTTT	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:69344215_69344221delCCTTTTT	ENST00000604392.1	-	0	698_704				RP3-525N10.2_ENST00000603261.1_RNA|RP3-525N10.2_ENST00000419979.1_RNA																							ATCCCTTTTCCCTTTTTCCTTTCTATA	0.406													4	4	---	---	---	---					
RP11-351A11.1	0	broad.mit.edu	37	6	119268430	119268432	+	RNA	DEL	ATC	ATC	-	rs77458334		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:119268430_119268432delATC	ENST00000518570.1	+	0	206																											gacaaaacttatcaaaacctctg	0.340													2	4	---	---	---	---					
RP11-138M12.1	0	broad.mit.edu	37	6	125758765	125758765	+	RNA	DEL	G	G	-	rs34044752		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:125758765delG	ENST00000430672.1	-	0	162																											aaaaaaaaaagattagatgag	0.413													4	2	---	---	---	---					
LOC100507406	100507406	broad.mit.edu	37	6	138054863	138054864	+	RNA	INS	-	-	T	rs113843461		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:138054863_138054864insT	ENST00000411615.1	-	0	275																											AACCTTGACACttttttttttt	0.455													3	6	---	---	---	---					
RP11-503C24.1	0	broad.mit.edu	37	6	168604993	168604994	+	RNA	INS	-	-	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr6:168604993_168604994insG	ENST00000457340.1	+	0	331																											tacagggggatgggggGCCCTA	0.520													3	4	---	---	---	---					
FAM126A	84668	broad.mit.edu	37	7	22936607	22936607	+	RNA	DEL	G	G	-	rs57885287		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:22936607delG	ENST00000421730.1	-	0	137																											aagtgtaagagggaggcaaag	0.483													4	2	---	---	---	---					
AC073325.1	0	broad.mit.edu	37	7	45542534	45542534	+	RNA	DEL	A	A	-	rs112431031		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:45542534delA	ENST00000443714.1	+	0	259																											ggcaaaaaggaaaaaaaaaaa	0.468													2	4	---	---	---	---					
RP11-467H10.2	0	broad.mit.edu	37	7	76679379	76679380	+	RNA	INS	-	-	CT	rs113718280	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:76679379_76679380insCT	ENST00000459742.1	+	0	58																											acagagcaagactgtctccaaa	0.416													2	4	---	---	---	---					
DLX6-AS1	285987	broad.mit.edu	37	7	96608206	96608207	+	RNA	INS	-	-	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:96608206_96608207insT	ENST00000430027.2	-	0	837_838				DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000458352.2_RNA|DLX6-AS1_ENST00000431497.2_RNA|DLX6-AS1_ENST00000605417.1_RNA|DLX6-AS1_ENST00000437331.2_RNA|DLX6-AS1_ENST00000430404.2_RNA	NR_015448.1																						CTTCCTCTTCATTTTCCTTACT	0.371													2	4	---	---	---	---					
ZAN	7455	broad.mit.edu	37	7	100373941	100373948	+	RNA	DEL	AGGGAGGG	AGGGAGGG	-	rs3991185		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:100373941_100373948delAGGGAGGG	ENST00000542585.1	+	0	6337				ZAN_ENST00000348028.3_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			actTGAaggaagggagggagggagggag	0.553													4	6	---	---	---	---					
LINC-PINT	378805	broad.mit.edu	37	7	130693477	130693477	+	RNA	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:130693477delA	ENST00000451786.1	-	0	1655																											AAGAAATTCCAAAGCACTATT	0.333													2	4	---	---	---	---					
RP11-728K20.2	0	broad.mit.edu	37	7	149700258	149700259	+	RNA	INS	-	-	TT			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr7:149700258_149700259insTT	ENST00000565102.1	+	0	2327																											gtgtgtgtgtgtgtggtgtgta	0.475													3	4	---	---	---	---					
RP11-941H19.3	0	broad.mit.edu	37	8	81192735	81192736	+	RNA	INS	-	-	A	rs144312229	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr8:81192735_81192736insA	ENST00000522044.1	+	0	218																											tcgtgtgtgggaagcctttggg	0.396													6	5	---	---	---	---					
CNBD1	168975	broad.mit.edu	37	8	88571817	88571820	+	RNA	DEL	AGAA	AGAA	-	rs3082607		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr8:88571817_88571820delAGAA	ENST00000440763.2	-	0	205																											agacacagagagaaagaaagaaag	0.353													3	4	---	---	---	---					
CASC8	727677	broad.mit.edu	37	8	128466629	128466644	+	RNA	DEL	TTAACCCATTCTATTA	TTAACCCATTCTATTA	-	rs56994994		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr8:128466629_128466644delTTAACCCATTCTATTA	ENST00000502082.1	-	0	1041				CASC8_ENST00000502056.1_RNA																							TGTTATGGCCTTAACCCATTCTATTATGCCTCCAAG	0.407													3	3	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130413859	130413860	+	RNA	INS	-	-	A	rs147516046		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr8:130413859_130413860insA	ENST00000446592.3	-	0	360																											attaaaaagttaaaaaaaaaaa	0.322													2	4	---	---	---	---					
CTD-2588J1.1	0	broad.mit.edu	37	8	134801142	134801143	+	RNA	DEL	TC	TC	-	rs5895207		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr8:134801142_134801143delTC	ENST00000517695.1	+	0	154																											AAAATGGAGAtctctctctctc	0.376													3	4	---	---	---	---					
RP11-149P24.1	0	broad.mit.edu	37	8	137118147	137118147	+	RNA	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr8:137118147delT	ENST00000523150.1	+	0	330																											CAGGGCAGAATCCATCAGATG	0.458													2	4	---	---	---	---					
LOC101930053	101930053	broad.mit.edu	37	9	2525942	2525943	+	RNA	INS	-	-	TCTC	rs140398159	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:2525942_2525943insTCTC	ENST00000416826.2	-	0	434																											ctttctctctttctctctctct	0.446													3	2	---	---	---	---					
VLDLR-AS1	401491	broad.mit.edu	37	9	2584752	2584753	+	RNA	INS	-	-	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:2584752_2584753insG	ENST00000416826.2	-	0	185				RP11-125B21.2_ENST00000453601.1_RNA																							aaaacatatttgggggaataat	0.386													2	4	---	---	---	---					
MIR31HG	554202	broad.mit.edu	37	9	21513701	21513705	+	RNA	DEL	AGGCT	AGGCT	-	rs56812146		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:21513701_21513705delAGGCT	ENST00000304425.3	-	0	181					NR_027054.1																						TCTTGTCCTGAGGCTAGGTAACTTG	0.395													5	7	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68406993	68406994	+	RNA	INS	-	-	AA	rs142369550	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr9:68406993_68406994insAA	ENST00000417843.2	-	0	224																											taagggtagggaaagagtctgt	0.446													3	6	---	---	---	---					
LINC00709	100507163	broad.mit.edu	37	10	9323424	9323424	+	RNA	DEL	T	T	-	rs146309697		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr10:9323424delT	ENST00000458168.1	+	0	28																											TGCCTTCTGCttttttttttt	0.393													3	5	---	---	---	---					
RP11-135D11.2	0	broad.mit.edu	37	10	61365215	61365216	+	RNA	INS	-	-	CTAAA	rs148496396	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr10:61365215_61365216insCTAAA	ENST00000450677.1	+	0	419																											tgAAAAGAAAGCTAAATTTCAT	0.351													2	4	---	---	---	---					
LOC102724589	102724589	broad.mit.edu	37	10	116754571	116754572	+	RNA	INS	-	-	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr10:116754571_116754572insC	ENST00000433085.1	+	0	129																											CTAGGCTGTAACCCCCACCATC	0.550													2	4	---	---	---	---					
TCERG1L	256536	broad.mit.edu	37	10	132891433	132891433	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr10:132891433delT	ENST00000368642.4	-	12	1838	c.1753delA	c.(1753-1755)tgfs	p.M585fs		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	585										cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		ACTCATCTCATTTTCCGCAGC	0.517													10	35	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14102302	14102302	+	RNA	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:14102302delT	ENST00000310358.7	+	0	1211							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		TCAGCATGCCTTTTTTTTACT	0.478													2	4	---	---	---	---					
RP1-65P5.1	0	broad.mit.edu	37	11	32268692	32268693	+	RNA	DEL	GG	GG	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:32268692_32268693delGG	ENST00000525689.1	-	0	122																											aaggtcttcaggggcaataatc	0.460													2	4	---	---	---	---					
RP11-718B12.2	0	broad.mit.edu	37	11	82504288	82504289	+	RNA	DEL	AC	AC	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr11:82504288_82504289delAC	ENST00000526305.1	+	0	63																											acacacataaacacacacacac	0.480													2	4	---	---	---	---					
LOC283440	283440	broad.mit.edu	37	12	2877533	2877533	+	RNA	DEL	C	C	-	rs74199312		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:2877533delC	ENST00000536497.1	-	0	147				RP11-885B4.1_ENST00000540093.1_lincRNA	NR_033958.1																						gtgaacccctcaaagccaggt	0.522													9	86	---	---	---	---					
LOC283440	283440	broad.mit.edu	37	12	2877627	2877627	+	RNA	DEL	C	C	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:2877627delC	ENST00000536497.1	-	0	147				RP11-885B4.1_ENST00000540093.1_lincRNA	NR_033958.1																						gtgaacccctcaaagccaggT	0.542													14	148	---	---	---	---					
LOC101930452	101930452	broad.mit.edu	37	12	9548694	9548695	+	RNA	INS	-	-	TG	rs71929516	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:9548694_9548695insTG	ENST00000567749.1	+	0	2869_2870																											acattcgcgcctgtgtgtgtgt	0.495													2	4	---	---	---	---					
RP11-4N23.1	0	broad.mit.edu	37	12	13681415	13681415	+	RNA	DEL	A	A	-	rs112849187		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:13681415delA	ENST00000535528.1	+	0	94																											TCTAACCTATAAAATGGGAGT	0.323													5	3	---	---	---	---					
RP11-90C1.1	0	broad.mit.edu	37	12	78835362	78835362	+	RNA	DEL	T	T	-	rs71941566		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:78835362delT	ENST00000547569.1	-	0	812				RP11-754N21.1_ENST00000548963.1_lincRNA																							AAAGATAATCTTTTTTTTTTT	0.343													2	4	---	---	---	---					
LOC643339	643339	broad.mit.edu	37	12	93747318	93747318	+	RNA	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr12:93747318delA	ENST00000552835.1	-	0	280				RP11-486A14.2_ENST00000549806.1_RNA|RP11-486A14.2_ENST00000548890.1_RNA																							CAACCACTAGAAAAAAAAAtt	0.453													2	4	---	---	---	---					
EEF1DP3	196549	broad.mit.edu	37	13	32519869	32519869	+	RNA	DEL	T	T	-	rs139284204		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr13:32519869delT	ENST00000428783.1	+	0	158																											CAACTGATGGTTTTTTTTTTT	0.403													4	3	---	---	---	---					
RP11-114G1.2	0	broad.mit.edu	37	13	90139450	90139451	+	RNA	DEL	AC	AC	-	rs62683560		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr13:90139450_90139451delAC	ENST00000425048.1	-	0	136																											CCTTCTCTCAacacacacacac	0.366													3	5	---	---	---	---					
LINC00410	144776	broad.mit.edu	37	13	91568280	91568280	+	RNA	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr13:91568280delT	ENST00000419272.1	-	0	117					NR_027039.1																						ATGGAAGCTCTTTTTTTTGCA	0.388													2	4	---	---	---	---					
LINC00871	100506412	broad.mit.edu	37	14	46964691	46964692	+	RNA	INS	-	-	T			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr14:46964691_46964692insT	ENST00000556886.1	+	0	349					NR_102701.1																						AGTCTTGGTCCTTTTTTTCAGT	0.391													2	4	---	---	---	---					
RP11-2G1.1	0	broad.mit.edu	37	14	48904559	48904560	+	RNA	DEL	TC	TC	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr14:48904559_48904560delTC	ENST00000555693.1	-	0	123																											acttcctccttctctctctctc	0.525													4	2	---	---	---	---					
LOC100128233	100128233	broad.mit.edu	37	14	65683107	65683108	+	RNA	INS	-	-	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr14:65683107_65683108insG	ENST00000531609.1	-	0	408					NR_103769.1																						TCAGACTATCTGGGGGGAAAAG	0.431													2	4	---	---	---	---					
RP11-789A21.1	0	broad.mit.edu	37	14	85689390	85689391	+	RNA	INS	-	-	A			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr14:85689390_85689391insA	ENST00000556016.1	-	0	209																											CTGCAACTTTTAAAAATCACTG	0.416													2	4	---	---	---	---					
GPR65	8477	broad.mit.edu	37	14	88478143	88478143	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr14:88478143delC	ENST00000267549.3	+	2	1510	c.952delC	c.(952-954)aafs	p.Q318fs	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	318					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						ATCACAAAGACAAAGAAAACG	0.358													11	43	---	---	---	---					
RP11-403B2.7	0	broad.mit.edu	37	15	20941993	20941993	+	RNA	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr15:20941993delA	ENST00000564214.1	-	0	254																											ttctgaaaagaaaaaaaaaaa	0.348													3	5	---	---	---	---					
DPH6-AS1	100507466	broad.mit.edu	37	15	36016208	36016209	+	RNA	DEL	AG	AG	-	rs113843236		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr15:36016208_36016209delAG	ENST00000501169.2	+	0	462					NR_038251.1																						agagcgagaaagagagcgaaag	0.361													3	3	---	---	---	---					
RP11-507B12.2	0	broad.mit.edu	37	15	61825595	61825595	+	RNA	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr15:61825595delA	ENST00000559783.1	-	0	123																											TAGATGAGAGAAAAGGCCTCA	0.448													2	4	---	---	---	---					
RP11-507B12.2	0	broad.mit.edu	37	15	61851993	61851994	+	RNA	DEL	TT	TT	-	rs56156446		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr15:61851993_61851994delTT	ENST00000559783.1	-	0	123																											cttctatctcttttccacctct	0.455													3	5	---	---	---	---					
RP11-798K3.2	0	broad.mit.edu	37	15	67349063	67349064	+	RNA	INS	-	-	T	rs112364779		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr15:67349063_67349064insT	ENST00000558071.1	-	0	114																											tcttctctctcttttttttttt	0.455													2	4	---	---	---	---					
RP11-1006G14.1	0	broad.mit.edu	37	15	72909977	72909978	+	RNA	INS	-	-	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr15:72909977_72909978insG	ENST00000563464.1	+	0	1827_1828				RP11-1006G14.2_ENST00000565305.1_lincRNA																							tgtgcttctgtggggggaaGCC	0.465													2	4	---	---	---	---					
RP11-382A20.4	0	broad.mit.edu	37	15	84099378	84099379	+	RNA	INS	-	-	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr15:84099378_84099379insC	ENST00000565495.1	+	0	264																											TTCCAATCCCACCCCCCCCTTA	0.490													2	4	---	---	---	---					
RP11-142A12.1	0	broad.mit.edu	37	16	26740279	26740280	+	RNA	DEL	TC	TC	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr16:26740279_26740280delTC	ENST00000562900.1	+	0	549_550																											TCGCTTGCTTTCTCTCTCTCTC	0.431													2	4	---	---	---	---					
RRN3P2	653390	broad.mit.edu	37	16	29113498	29113498	+	RNA	DEL	T	T	-	rs11366120		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr16:29113498delT	ENST00000564580.1	+	0	1360																											AGGAGGTGGAttttttttttc	0.542													3	5	---	---	---	---					
CCDC144NL-AS1	440416	broad.mit.edu	37	17	20870101	20870101	+	RNA	DEL	C	C	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr17:20870101delC	ENST00000582583.1	+	0	799				RP11-344E13.3_ENST00000581958.1_RNA|RP11-344E13.3_ENST00000583481.1_RNA|RP11-344E13.3_ENST00000580056.1_RNA|RP11-344E13.3_ENST00000423473.2_RNA|RP11-344E13.3_ENST00000439794.2_RNA|RP11-381P6.1_ENST00000581673.1_RNA																							GGGGAAATTTCCATCTCTAAT	0.433													2	4	---	---	---	---					
LOC339192	339192	broad.mit.edu	37	17	43276430	43276430	+	RNA	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr17:43276430delT	ENST00000586376.1	-	0	604																											cctcttctcctttttttttga	0.423													2	4	---	---	---	---					
LOC100288866	100288866	broad.mit.edu	37	17	47593808	47593809	+	RNA	DEL	AG	AG	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr17:47593808_47593809delAG	ENST00000514506.1	-	0	246					NR_103773.1																						cccagagcccagagagtgagta	0.619													2	4	---	---	---	---					
LINC01476	101927728	broad.mit.edu	37	17	57511677	57511678	+	RNA	INS	-	-	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr17:57511677_57511678insG	ENST00000584262.1	-	0	583																											ctcacagttcaggggggacata	0.455													2	4	---	---	---	---					
ROCK1P1	727758	broad.mit.edu	37	18	112369	112370	+	RNA	INS	-	-	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr18:112369_112370insG	ENST00000576266.1	+	0	3_4																											AGCCAGGTGTTCCCCGCGAAAG	0.688													2	4	---	---	---	---					
RP11-449D8.5	0	broad.mit.edu	37	18	22326225	22326226	+	RNA	DEL	AC	AC	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr18:22326225_22326226delAC	ENST00000582650.1	+	0	235																											Gcacacacagacacacacacac	0.485													2	4	---	---	---	---					
RP11-449D8.5	0	broad.mit.edu	37	18	22495117	22495119	+	RNA	DEL	AGG	AGG	-	rs72351746		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr18:22495117_22495119delAGG	ENST00000582650.1	+	0	235																											ATTTAGAAACaggaggaggagga	0.493													5	1	---	---	---	---					
KC6	641516	broad.mit.edu	37	18	39060522	39060523	+	RNA	INS	-	-	G			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr18:39060522_39060523insG	ENST00000592302.1	-	0	1424_1425					NR_002838.1																						CATACAAAACTGGGGGGCACAA	0.426													2	4	---	---	---	---					
C3	718	broad.mit.edu	37	19	6697480	6697481	+	Frame_Shift_Ins	INS	-	-	G	rs137956083		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr19:6697480_6697481insG	ENST00000245907.6	-	21	2762_2763	c.2670_2671insC	c.(2668-2673)ccagtcfs	p.V891fs		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	891					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		AACGAGGACTTGGGGGGGATGG	0.574													7	68	---	---	---	---					
ZIM2-AS1	101929059	broad.mit.edu	37	19	57219135	57219136	+	RNA	INS	-	-	T	rs72530679	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr19:57219135_57219136insT	ENST00000594400.1	+	0	208				AC006115.3_ENST00000600093.1_RNA|AC006115.3_ENST00000597822.1_RNA																							CTACCCTGACATTATTGAAAAT	0.396													3	3	---	---	---	---					
ZNF551	90233	broad.mit.edu	37	19	58204033	58204033	+	Frame_Shift_Del	DEL	A	A	-	rs76200340		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr19:58204033delA	ENST00000597520.1	-	1	95	c.96delT	c.(94-96)ttfs	p.F32fs	AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000596085.1_Intron																							actccgtctcaaaaaaaaaaa	0.512													3	4	---	---	---	---					
KIZ-AS1	101929591	broad.mit.edu	37	20	21159850	21159850	+	RNA	DEL	T	T	-	rs149456856		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr20:21159850delT	ENST00000591761.1	-	0	5051				PLK1S1_ENST00000457464.1_RNA																							ggtttttttgttttttttttt	0.313													5	2	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29589550	29589550	+	RNA	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr20:29589550delT	ENST00000432067.1	-	0	152																											tgacctaagatttgatctatc	0.323													2	4	---	---	---	---					
RP11-445H22.4	0	broad.mit.edu	37	20	43326138	43326139	+	RNA	DEL	CT	CT	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr20:43326138_43326139delCT	ENST00000427598.1	-	0	246				RP11-445H22.4_ENST00000445420.1_RNA																							gcagatattcctctctCTCTCT	0.396													3	3	---	---	---	---					
LINC00494	284749	broad.mit.edu	37	20	46994261	46994262	+	RNA	INS	-	-	C			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr20:46994261_46994262insC	ENST00000416742.1	+	0	510					NR_026958.1																						gcagcacacagccccccagaag	0.475													2	4	---	---	---	---					
MIR646HG	284757	broad.mit.edu	37	20	58889846	58889846	+	RNA	DEL	C	C	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr20:58889846delC	ENST00000432910.1	+	0	332					NR_046099.1																						atcctcccatccatccatcca	0.547													3	3	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11072388	11072389	+	RNA	INS	-	-	T	rs139874484		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr21:11072388_11072389insT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tggttcacgccgtgattccagc	0.505													5	6	---	---	---	---					
AP000282.2	0	broad.mit.edu	37	21	34350174	34350181	+	RNA	DEL	GTGTGTGC	GTGTGTGC	-	rs138491450	by1000genomes	TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr21:34350174_34350181delGTGTGTGC	ENST00000420356.1	-	0	201				AP000282.2_ENST00000454622.1_RNA																							gtgtgtgcatgtgtgtgcgtgtgtgtgt	0.495													3	4	---	---	---	---					
LOC101928233	101928233	broad.mit.edu	37	21	44030057	44030060	+	RNA	DEL	CGCA	CGCA	-	rs67305845		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr21:44030057_44030060delCGCA	ENST00000419628.1	-	0	206																											gccatgtgaccgcacccaaccaca	0.529													2	4	---	---	---	---					
CTA-833B7.2	0	broad.mit.edu	37	22	37250509	37250509	+	RNA	DEL	A	A	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chr22:37250509delA	ENST00000330602.2	-	0	349																											actggaaaacaaaaaaaaaac	0.323													2	4	---	---	---	---					
LOC101928495	101928495	broad.mit.edu	37	X	125243955	125243956	+	RNA	INS	-	-	GGCTCG	rs71940569		TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:125243955_125243956insGGCTCG	ENST00000438994.1	+	0	102_103																											caccctgcttccacacggtgcg	0.564													2	4	---	---	---	---					
FIRRE	286467	broad.mit.edu	37	X	130838851	130838851	+	RNA	DEL	T	T	-			TCGA-17-Z037-01A-01W-0746-08	TCGA-17-Z037-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bffe237d-31b0-4950-a7ab-4ac7047aa3c0	a403da0b-0d52-4223-89d6-043a49fe666f	g.chrX:130838851delT	ENST00000427391.1	-	0	2059					NR_026975.1																						AACAACGTTCTTCCAGGGGAG	0.458											OREG0019926	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---