Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DIS3L2	129563	broad.mit.edu	37	2	233028203	233028203	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:233028203A>T	ENST00000325385.7	+	9	1261	c.985A>T	c.(985-987)Att>Ttt	p.I329F	DIS3L2_ENST00000409307.1_Missense_Mutation_p.I329F|DIS3L2_ENST00000360410.4_Missense_Mutation_p.K348N|DIS3L2_ENST00000273009.6_Missense_Mutation_p.I329F	NM_152383.4	NP_689596.4	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like 2	329							exonuclease activity|ribonuclease activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(2)|urinary_tract(1)	40		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		GGCTGGTGAAATTGAGCCTGA	0.453000													10	26					0	0	0.058154	0	0
POU3F2	5454	broad.mit.edu	37	6	99283514	99283514	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:99283514C>A	ENST00000328345.5	+	1	935	c.765C>A	c.(763-765)caC>caA	p.H255Q		NM_005604.3	NP_005595.2	P20265	PO3F2_HUMAN	POU class 3 homeobox 2	255					positive regulation of cell proliferation		identical protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(5)	10		all_cancers(76;1.56e-06)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00893)|Colorectal(196;0.069)|Lung NSC(302;0.197)		BRCA - Breast invasive adenocarcinoma(108;0.0355)		CAGGCGCGCACCACGACCCGC	0.706000													9	36					0.00621372	0.00674442	0.058154	1	0
PRUNE2	158471	broad.mit.edu	37	9	79326184	79326184	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:79326184C>T	ENST00000376718.3	-	8	1129	c.1006G>A	c.(1006-1008)Gag>Aag	p.E336K	PRUNE2_ENST00000428286.1_5'UTR	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	336					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GAAGGGTCCTCTTGTTGGTAC	0.512000													5	17					0	0	0.021553	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20496657	20496657	+	RNA	SNP	C	C	T	rs7180374	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:20496657C>T	ENST00000555186.1	+	0	710					NR_038836.1																						GACCACAAAGCGCCCGGCTGT	0.438000													9	49					0	0	0.058154	0	0
FGD3	89846	broad.mit.edu	37	9	95776272	95776272	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:95776272C>T	ENST00000375482.3	+	9	1670	c.1174C>T	c.(1174-1176)Ctc>Ttc	p.L392F	FGD3_ENST00000337352.6_Missense_Mutation_p.L392F|FGD3_ENST00000416701.2_Missense_Mutation_p.L392F	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	392	PH 1.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						GGACCGCCACCTCTTCCTGGT	0.632000													4	46					0	0	0.033300	0	0
MIA3	375056	broad.mit.edu	37	1	222805568	222805568	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:222805568G>T	ENST00000344922.5	+	5	3256	c.3231G>T	c.(3229-3231)caG>caT	p.Q1077H	MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000344507.1_Intron|MIA3_ENST00000344441.6_Missense_Mutation_p.Q1077H	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1077					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		TTAATGTGCAGGTTCCTGAAG	0.483000													25	88					1.08312e-15	1.46823e-15	0.041601	1	0
OR5D14	219436	broad.mit.edu	37	11	55563066	55563066	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:55563066C>T	ENST00000335605.1	+	1	35	c.35C>T	c.(34-36)cCc>cTc	p.P12L		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				AGCATGGAGCCCACCTTTGCC	0.408000													4	78					0	0	0.021553	0	0
DOCK9	23348	broad.mit.edu	37	13	99462449	99462449	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr13:99462449T>C	ENST00000376460.1	-	47	5307	c.5227A>G	c.(5227-5229)Att>Gtt	p.I1743V	DOCK9_ENST00000339416.2_Missense_Mutation_p.I1744V|DOCK9_ENST00000448493.2_3'UTR	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1744	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTCTCATAAATGGGGATGATA	0.473000													53	63					0	0	0.048971	0	0
DENND5B	160518	broad.mit.edu	37	12	31633142	31633142	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:31633142T>G	ENST00000389082.5	-	3	549	c.285A>C	c.(283-285)aaA>aaC	p.K95N	DENND5B_ENST00000354285.4_Missense_Mutation_p.K117N|DENND5B_ENST00000536562.1_Missense_Mutation_p.K130N|DENND5B_ENST00000545147.1_Intron|DENND5B_ENST00000306833.6_Missense_Mutation_p.K130N	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	95	UDENN.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						ACTGGGGGTCTTTATTGTCCG	0.363000													4	26					0	0	0.021553	0	0
EPHA6	285220	broad.mit.edu	37	3	97439124	97439124	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:97439124G>T	ENST00000389672.5	+	15	2842	c.2804G>T	c.(2803-2805)aGg>aTg	p.R935M		NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	840	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						ATCCCCATAAGGTGGACAGCC	0.413000													13	39					2.32078e-09	2.97411e-09	0.024245	1	0
SEMA3A	10371	broad.mit.edu	37	7	83823799	83823799	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:83823799G>C	ENST00000265362.3	-	1	418	c.104C>G	c.(103-105)tCc>tGc	p.S35C	SEMA3A_ENST00000436949.1_Missense_Mutation_p.S35C	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	35	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						ACCTTTGTAGGATAATTTCAG	0.403000													23	55					0	0	0.099896	0	0
TRAPPC1	58485	broad.mit.edu	37	17	7834428	7834428	+	Silent	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:7834428T>C	ENST00000303731.4	-	3	325	c.210A>G	c.(208-210)aaA>aaG	p.K70K	TRAPPC1_ENST00000540486.1_Silent_p.K70K	NM_021210.4	NP_067033.1	Q9Y5R8	TPPC1_HUMAN	trafficking protein particle complex 1	70					ER to Golgi vesicle-mediated transport	endoplasmic reticulum				breast(1)|lung(2)	3		Prostate(122;0.173)				AGTAATGGAGTTTGTAACGGC	0.512000													10	18					0	0	0.093190	0	0
TRIM51	84767	broad.mit.edu	37	11	55653094	55653094	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:55653094C>T	ENST00000449290.2	+	2	282	c.190C>T	c.(190-192)Ctc>Ttc	p.L64F		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	64						intracellular	zinc ion binding										GCAGAGAAACCTCAACACTGA	0.502000													9	11					0	0	0.058154	0	0
HTR1E	3354	broad.mit.edu	37	6	87726013	87726013	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:87726013G>T	ENST00000305344.4	+	2	1664	c.961G>T	c.(961-963)Gtg>Ttg	p.V321L	HTR1E_ENST00000369584.1_Missense_Mutation_p.V321L	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	321					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CATCTACACCGTGTCCTCGGA	0.483000													64	202					2.43199e-30	3.54907e-30	0.048971	1	0
SIGLEC10	89790	broad.mit.edu	37	19	51914558	51914558	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:51914558G>A	ENST00000353836.5	-	10	1825	c.1604C>T	c.(1603-1605)tCc>tTc	p.S535F	SIGLEC10_ENST00000436984.2_Missense_Mutation_p.S487F|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.S387F|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.S572F|SIGLEC10_ENST00000441969.3_Missense_Mutation_p.S477F|SIGLEC10_ENST00000339313.5_Missense_Mutation_p.S630F|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.S630F|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.S452F|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.S445F	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	630					cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		TGATTCTGGGGAGGGAGCACC	0.517000													28	38					0	0	0.034045	0	0
TRIM43	129868	broad.mit.edu	37	2	96261979	96261979	+	Silent	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:96261979C>A	ENST00000272395.2	+	4	673	c.537C>A	c.(535-537)atC>atA	p.I179I		NM_001164464.1|NM_138800.1	NP_001157936.1|NP_620155.1	Q96BQ3	TRI43_HUMAN	tripartite motif containing 43	179						intracellular	zinc ion binding			breast(1)|large_intestine(3)|lung(7)|ovary(1)	12						CACAGATGATCAGGAATGAGT	0.428000													4	19					0.014758	0.015575	0.014758	1	0
SERPINA11	256394	broad.mit.edu	37	14	94914753	94914753	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr14:94914753C>A	ENST00000334708.3	-	2	423	c.359G>T	c.(358-360)cGg>cTg	p.R120L	RP11-349I1.2_ENST00000536735.1_RNA	NM_001080451.1	NP_001073920.1	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	120					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(14)|skin(1)|upper_aerodigestive_tract(1)	24				COAD - Colon adenocarcinoma(157;0.211)		GAGGAGGCTCCGGAAGCCCTG	0.572000													64	110					1.77355e-41	2.65164e-41	0.048971	1	0
SPEG	10290	broad.mit.edu	37	2	220354245	220354245	+	Silent	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:220354245C>G	ENST00000312358.7	+	36	8637	c.8505C>G	c.(8503-8505)ctC>ctG	p.L2835L	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2835	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TGTCCTCGCTCAAGGCTGTGG	0.687000													4	28					0	0	0.009096	0	0
DNM1P46	196968	broad.mit.edu	37	15	100332723	100332723	+	RNA	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:100332723G>T	ENST00000341853.1	-	0	1468					NR_003260.1																						gggggtgggcgtgagggtggg	0.602000													9	37					0.00448238	0.00488259	0.047766	1	0
FAM214B	80256	broad.mit.edu	37	9	35107982	35107982	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:35107982G>A	ENST00000378561.1	-	2	3345	c.290C>T	c.(289-291)tCt>tTt	p.S97F	FAM214B_ENST00000603301.1_Missense_Mutation_p.S97F|FAM214B_ENST00000378566.1_Intron|FAM214B_ENST00000605244.1_Missense_Mutation_p.S97F|FAM214B_ENST00000322813.5_Missense_Mutation_p.S97F|FAM214B_ENST00000378554.2_Missense_Mutation_p.S97F|FAM214B_ENST00000488109.2_Missense_Mutation_p.S97F|FAM214B_ENST00000378557.1_Missense_Mutation_p.S97F			Q7L5A3	K1539_HUMAN	family with sequence similarity 214, member B	97						nucleus											CCCCACAGTAGATGGTTCTTC	0.632000													6	98					0	0	0.029380	0	0
NNMT	4837	broad.mit.edu	37	11	114182962	114182962	+	Silent	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:114182962A>T	ENST00000535401.1	+	5	822	c.558A>T	c.(556-558)ctA>ctT	p.L186L	NNMT_ENST00000541754.1_5'UTR|RP11-64D24.2_ENST00000544925.1_RNA|NNMT_ENST00000299964.3_Silent_p.L186L|NNMT_ENST00000545255.1_5'UTR|NNMT_ENST00000542647.1_5'UTR			P40261	NNMT_HUMAN	nicotinamide N-methyltransferase	186					xenobiotic metabolic process	cytosol	nicotinamide N-methyltransferase activity|pyridine N-methyltransferase activity			kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;4.83e-16)|all_epithelial(67;7.28e-09)|all_hematologic(158;0.000135)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.79e-06)|Epithelial(105;1.32e-05)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.128)	Niacin(DB00627)	TCGGCAGCCTACTGAAGCCAG	0.632000													8	17					0	0	0.047766	0	0
SELL	6402	broad.mit.edu	37	1	169677568	169677568	+	Silent	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:169677568G>C	ENST00000236147.4	-	3	661	c.501C>G	c.(499-501)ctC>ctG	p.L167L	C1orf112_ENST00000498289.1_Intron|SELL_ENST00000463108.1_5'UTR	NM_000655.4	NP_000646.2	P14151	LYAM1_HUMAN	selectin L	154	EGF-like.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	15	all_hematologic(923;0.208)					CTGTGTAACAGAGGGCTGCCT	0.498000													26	161					0	0	0.045705	0	0
PNCK	139728	broad.mit.edu	37	X	152936415	152936415	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:152936415G>T	ENST00000393831.2	-	9	1267	c.833C>A	c.(832-834)cCc>cAc	p.P278H	PNCK_ENST00000370142.1_Missense_Mutation_p.P278H|PNCK_ENST00000370145.4_Missense_Mutation_p.P272H|PNCK_ENST00000370150.1_Missense_Mutation_p.P255H|PNCK_ENST00000447676.2_Missense_Mutation_p.P338H|PNCK_ENST00000340888.3_Missense_Mutation_p.P255H	NM_001039582.3	NP_001034671.3	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase	255						cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTCTTCTGGGGGTCTCGCTC	0.632000													21	55					2.98393e-07	3.6404e-07	0.076483	1	0
SGTB	54557	broad.mit.edu	37	5	64976348	64976348	+	Silent	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:64976348C>T	ENST00000381007.4	-	8	889	c.654G>A	c.(652-654)ttG>ttA	p.L218L		NM_019072.2	NP_061945.1	Q96EQ0	SGTB_HUMAN	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta	218							binding			large_intestine(3)|lung(3)|skin(3)	9		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Breast(144;0.174)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0657)|Lung(70;0.00487)		GATTATTTATCAAGCTAGCCA	0.348000													4	6					0	0	0.009096	0	0
ALK	238	broad.mit.edu	37	2	29940452	29940452	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:29940452C>A	ENST00000389048.3	-	2	1685	c.779G>T	c.(778-780)aGc>aTc	p.S260I	ALK_ENST00000431873.1_Missense_Mutation_p.S260I	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	260					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	ACCATATCGGCTGCGATGAGA	0.388000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				27	40					1.38267e-23	1.98922e-23	0.108266	1	0
XYLT1	64131	broad.mit.edu	37	16	17352994	17352994	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr16:17352994G>A	ENST00000261381.6	-	3	848	c.764C>T	c.(763-765)cCt>cTt	p.P255L		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	255					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GTCACACTTAGGGGGCTGGTC	0.612000													22	140					0	0	0.069288	0	0
NUP35	129401	broad.mit.edu	37	2	184022190	184022190	+	Silent	SNP	T	T	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:184022190T>G	ENST00000295119.4	+	6	661	c.558T>G	c.(556-558)gcT>gcG	p.A186A	NUP35_ENST00000541912.1_Silent_p.A51A|NUP35_ENST00000409798.1_Silent_p.A169A	NM_138285.3	NP_612142.2	Q8NFH5	NUP53_HUMAN	nucleoporin 35kDa	186	RRM Nup35-type.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	intermediate filament cytoskeleton|nuclear membrane|nuclear pore|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	8						AAGCATCTGCTTCCTACATAT	0.333000													4	36					0	0	0.014758	0	0
ADAMTSL4	54507	broad.mit.edu	37	1	150530998	150530998	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:150530998T>C	ENST00000271643.4	+	15	2668	c.2432T>C	c.(2431-2433)gTt>gCt	p.V811A	ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.V811A|ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.V834A|ADAMTSL4_ENST00000369041.5_Missense_Mutation_p.V811A	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	811	TSP type-1 3.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GTTCGCTGTGTTGGGAACAAT	0.667000													3	18					0	0	0.014758	0	0
TTLL9	164395	broad.mit.edu	37	20	30497669	30497669	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:30497669C>T	ENST00000375938.4	+	6	701	c.448C>T	c.(448-450)Cac>Tac	p.H150Y	TTLL9_ENST00000375922.4_Missense_Mutation_p.H100Y|TTLL9_ENST00000535842.1_Missense_Mutation_p.H150Y|TTLL9_ENST00000310998.4_Missense_Mutation_p.H100Y|TTLL9_ENST00000375934.4_Missense_Mutation_p.H132Y|TTLL9_ENST00000375921.2_Missense_Mutation_p.H100Y			Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	150	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TTGCGAGTACCACCTGTTTGT	0.567000													6	40					0	0	0.038147	0	0
LRRC20	55222	broad.mit.edu	37	10	72061136	72061136	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:72061136C>A	ENST00000355790.4	-	5	1006	c.529G>T	c.(529-531)Gaa>Taa	p.E177*	LRRC20_ENST00000373224.1_Nonsense_Mutation_p.E177*|LRRC20_ENST00000358141.2_Nonsense_Mutation_p.E127*|LRRC20_ENST00000395011.1_Nonsense_Mutation_p.E127*|LRRC20_ENST00000395010.1_Nonsense_Mutation_p.E121*	NM_001278212.1|NM_001278214.1|NM_207119.1	NP_001265141.1|NP_001265143.1|NP_997002.1	Q8TCA0	LRC20_HUMAN	leucine rich repeat containing 20	177										endometrium(2)|large_intestine(4)|lung(2)|urinary_tract(1)	9						CTTGCGCCTTCCGGAGACATG	0.647000													16	74					8.34094e-07	1.00553e-06	0.049695	1	0
MTMR8	55613	broad.mit.edu	37	X	63444978	63444978	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:63444978G>A	ENST00000453546.1	-	10	1767	c.1678C>T	c.(1678-1680)Ctc>Ttc	p.L560F	ASB12_ENST00000396130.2_Missense_Mutation_p.L176F|ASB12_ENST00000362002.2_Missense_Mutation_p.L185F			Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	0						nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)|p.L176I(1)|p.L185I(1)|p.L560I(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						GCCAAATAGAGGGGGCCAGAA	0.557000													41	33					0	0	0.045515	0	0
KEAP1	9817	broad.mit.edu	37	19	10602799	10602799	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:10602799C>A	ENST00000171111.5	-	3	1326	c.779G>T	c.(778-780)cGa>cTa	p.R260L	KEAP1_ENST00000588024.1_5'UTR|KEAP1_ENST00000393623.2_Missense_Mutation_p.R260L	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	260	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding	p.R260Q(1)		breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GTAGAACCGTCGCTGTTCGCA	0.627000													8	10					3.09899e-07	3.75076e-07	0.047766	1	0
ZBTB39	9880	broad.mit.edu	37	12	57396734	57396734	+	Silent	SNP	C	C	A	rs148071081	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:57396734C>A	ENST00000300101.2	-	2	2053	c.1968G>T	c.(1966-1968)tcG>tcT	p.S656S		NM_014830.2	NP_055645.1	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	656					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|prostate(1)	16						TGAGGGCCCCCGAGTGTGTCT	0.572000													28	61					4.74835e-14	6.32423e-14	0.045705	1	0
THBS4	7060	broad.mit.edu	37	5	79368108	79368108	+	Silent	SNP	A	A	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:79368108A>G	ENST00000350881.2	+	14	1918	c.1728A>G	c.(1726-1728)aaA>aaG	p.K576K	THBS4_ENST00000511733.1_Silent_p.K485K|CTD-2201I18.1_ENST00000514042.1_RNA|CTD-2201I18.1_ENST00000503007.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	576					endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		CAGGAATAAAAAACATTCTGG	0.493000													55	122					0	0	0.048971	0	0
PRAME	23532	broad.mit.edu	37	22	22892423	22892423	+	Silent	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr22:22892423G>T	ENST00000543184.1	-	4	1540	c.678C>A	c.(676-678)atC>atA	p.I226I	PRAME_ENST00000398741.1_Silent_p.I226I|PRAME_ENST00000539862.1_Silent_p.I210I|PRAME_ENST00000402697.1_Silent_p.I226I|PRAME_ENST00000424204.2_Silent_p.I210I|PRAME_ENST00000398743.2_Silent_p.I226I|PRAME_ENST00000405655.3_Silent_p.I226I	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	226					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		CCATTTTCAGGATCATCTTGA	0.443000													4	18					2.0095e-06	2.39413e-06	0.029380	1	0
OR5D14	219436	broad.mit.edu	37	11	55563948	55563948	+	Nonsense_Mutation	SNP	T	T	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:55563948T>G	ENST00000335605.1	+	1	917	c.917T>G	c.(916-918)tTa>tGa	p.L306*		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				TTCTGGAAGTTAATACATACA	0.403000													6	12					0	0	0.021553	0	0
TTN	7273	broad.mit.edu	37	2	179414451	179414451	+	Silent	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:179414451G>T	ENST00000589042.1	-	338	92222	c.91998C>A	c.(91996-91998)gcC>gcA	p.A30666A	TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342992.6_Silent_p.A28098A|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000460472.2_Silent_p.A21601A|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592750.1_RNA|RP11-65L3.2_ENST00000603415.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.A29025A|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000359218.5_Silent_p.A21726A|TTN_ENST00000342175.6_Silent_p.A21793A|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29025	Ig-like 138.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAGTGCCCAGGCAAGTCTGC	0.453000													12	42					1.08611e-07	1.3466e-07	0.080935	1	0
TRIM42	287015	broad.mit.edu	37	3	140406869	140406869	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:140406869C>A	ENST00000286349.3	+	3	1536	c.1345C>A	c.(1345-1347)Ctg>Atg	p.L449M		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	449	COS.					intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AGCCAAGATCCTGGTGGACCA	0.552000													13	57					9.31168e-06	1.09233e-05	0.105934	1	0
RAB11FIP2	22841	broad.mit.edu	37	10	119805399	119805399	+	Silent	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:119805399C>A	ENST00000355624.3	-	1	715	c.276G>T	c.(274-276)gtG>gtT	p.V92V	RAB11FIP2_ENST00000369199.3_Silent_p.V92V	NM_014904.2	NP_055719.1	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2 (class I)	92	C2.|Necessary for its cellular translocation to the plasma membrane.				protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(8)	19		Colorectal(252;0.235)		all cancers(201;0.0238)		TATCCAGACCCACCAGGGACC	0.398000													5	13					1.23904e-05	1.44792e-05	0.014758	1	0
NHP2L1	4809	broad.mit.edu	37	22	42076369	42076369	+	Splice_Site	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr22:42076369C>G	ENST00000401959.1	-	3	320		c.e3-1		NHP2L1_ENST00000215956.5_Splice_Site|NHP2L1_ENST00000402458.1_Splice_Site|NHP2L1_ENST00000355257.3_Splice_Site|NHP2L1_ENST00000463675.1_Splice_Site	NM_005008.3	NP_004999.1	P55769	NH2L1_HUMAN	NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)						nuclear mRNA splicing, via spliceosome|ribosome biogenesis	box C/D snoRNP complex|nucleoplasm|spliceosomal complex	protein binding|RNA binding			endometrium(1)|kidney(1)|lung(1)|prostate(1)	4						CAGCCTCAGTCTATGGGGGGG	0.478000													3	31					0	0	0.014758	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11738	11738	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrM:11738T>C	ENST00000361381.2	+	1	979	c.979T>C	c.(979-981)Ttc>Ctc	p.327_327insL						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						CCTCATTACTATTCTGCCTAG	0.468000													7	727					0	0	0.047766	0	0
GABRQ	55879	broad.mit.edu	37	X	151820167	151820167	+	Silent	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:151820167C>A	ENST00000370306.2	+	8	1100	c.1080C>A	c.(1078-1080)cgC>cgA	p.R360R		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	360						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					GACCTCGGCGCCAGCCTAGGC	0.498000													19	47					2.54575e-18	3.54545e-18	0.055883	1	0
LRP1B	53353	broad.mit.edu	37	2	141202236	141202236	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:141202236C>T	ENST00000389484.3	-	64	11041	c.10070G>A	c.(10069-10071)tGt>tAt	p.C3357Y		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3357	LDL-receptor class A 22.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCCTGGCTGACATCTAAATTC	0.408000										TSP Lung(27;0.18)			14	32					0	0	0.020292	0	0
TRAJ16	28739	broad.mit.edu	37	14	22997530	22997530	+	RNA	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr14:22997530G>A	ENST00000390521.1	+	0	44																											GGGGAACCATGTTAAAGGTGG	0.368000													5	4					0	0	0.014758	0	0
MUC4	4585	broad.mit.edu	37	3	195515449	195515449	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:195515449A>T	ENST00000463781.3	-	2	3461	c.3002T>A	c.(3001-3003)gTa>gAa	p.V1001E	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.V1001E|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1006	Ser-rich.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.V1001A(1)|p.V1001E(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACCTGTGGATACTGAGGAAGC	0.587000													3	14					0	0	0.009096	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6723	6723	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrM:6723G>A	ENST00000361624.2	+	1	820	c.820G>A	c.(820-822)Gtc>Atc	p.274_274insI						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						ACATAGGTATGGTCTGAGCTA	0.388000													11	516					0	0	0.024245	0	0
BAGE2	85319	broad.mit.edu	37	21	11039127	11039127	+	RNA	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr21:11039127C>A	ENST00000470054.1	-	0	1076									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AACTGTTCCTCAGGACATAAT	0.398000													7	219					0.0381472	0.0397096	0.038147	1	0
MRO	83876	broad.mit.edu	37	18	48325711	48325711	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr18:48325711A>C	ENST00000428869.2	-	9	1001	c.743T>G	c.(742-744)cTg>cGg	p.L248R	MRO_ENST00000431965.2_Missense_Mutation_p.L210R|MRO_ENST00000398439.3_Missense_Mutation_p.L248R|MRO_ENST00000588444.1_Missense_Mutation_p.L196R|MRO_ENST00000256425.2_Missense_Mutation_p.L248R|MRO_ENST00000436348.2_Missense_Mutation_p.L262R			Q9BYG7	MSTRO_HUMAN	maestro	248						nucleolus	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)|skin(2)	10		Colorectal(6;0.0596)		Colorectal(21;0.082)		CTGCGCTTACAGAATTTTATT	0.463000													7	57					0	0	0.047766	0	0
IGDCC3	9543	broad.mit.edu	37	15	65667437	65667437	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:65667437G>T	ENST00000327987.4	-	2	658	c.407C>A	c.(406-408)gCa>gAa	p.A136E		NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	136	Ig-like C2-type 1.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CCACTTACTTGCAGCTTGGAT	0.582000													15	37					1.5739e-10	2.06025e-10	0.028581	1	0
IGHV3OR16-9	28307	broad.mit.edu	37	16	33647353	33647353	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr16:33647353C>T	ENST00000558425.1	-	2	246	c.247G>A	c.(247-249)Gtg>Atg	p.V83M																								CGGCCCTTCACAGAGTCTGCG	0.502000													34	167					0	0	0.080422	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303501	151303501	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:151303501C>A	ENST00000370323.4	-	4	908	c.592G>T	c.(592-594)Ggc>Tgc	p.G198C	MAGEA10_ENST00000244096.3_Missense_Mutation_p.G198C|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	198	MAGE.									endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					AAGGAGTGGCCAGTGGGATCC	0.488000													9	45					2.17888e-05	2.50776e-05	0.058154	1	0
OTUD7B	56957	broad.mit.edu	37	1	149943154	149943154	+	Silent	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:149943154G>A	ENST00000369135.3	-	3	405	c.111C>T	c.(109-111)gcC>gcT	p.A37A	OTUD7B_ENST00000479905.1_5'UTR	NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	37					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			AATCACTGAGGGCGGCATTCA	0.463000													7	83					0	0	0.047766	0	0
PUF60	22827	broad.mit.edu	37	8	144898802	144898802	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:144898802G>A	ENST00000526683.1	-	12	2123	c.1568C>T	c.(1567-1569)tCt>tTt	p.S523F	PUF60_ENST00000527197.1_Missense_Mutation_p.S477F|PUF60_ENST00000456095.2_Missense_Mutation_p.S494F|PUF60_ENST00000349157.6_Missense_Mutation_p.S506F|PUF60_ENST00000453551.2_Missense_Mutation_p.S480F|PUF60_ENST00000313352.7_Missense_Mutation_p.S463F	NM_001271098.1|NM_078480.1	NP_001258027.1|NP_510965.1	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa	523	Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.|RRM 3; atypical.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding			NS(1)|endometrium(1)|kidney(3)|lung(7)|prostate(2)	14	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			ATGAGTCTCAGAGGCTATGGA	0.527000													4	23					0	0	0.009096	0	0
BEND2	139105	broad.mit.edu	37	X	18213466	18213466	+	Missense_Mutation	SNP	G	G	T	rs28496595		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:18213466G>T	ENST00000380033.4	-	7	1262	c.1130C>A	c.(1129-1131)aCg>aAg	p.T377K	BEND2_ENST00000380030.3_Intron	NM_153346.4	NP_699177.2	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	377										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(11)|liver(1)|lung(21)|ovary(3)|prostate(1)	49						TGGGGCACTCGTATTTCCCGA	0.393000													10	38					9.70103e-10	1.24844e-09	0.069234	1	0
NLRP6	171389	broad.mit.edu	37	11	282701	282701	+	Splice_Site	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:282701G>T	ENST00000312165.5	+	5	2105		c.e5-1		NLRP6_ENST00000534750.1_Intron	NM_138329.1	NP_612202.2	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6							cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CTCTCTCCCAGCAGTTCTCAA	0.572000													8	9					0.0581538	0.0603296	0.058154	1	0
RHPN2	85415	broad.mit.edu	37	19	33517420	33517420	+	Translation_Start_Site	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:33517420G>C	ENST00000400226.4	-	0	339				RHPN2_ENST00000254260.3_Missense_Mutation_p.Q102E			Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2						signal transduction	perinuclear region of cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(5)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(3)|urinary_tract(1)	44	Esophageal squamous(110;0.137)					TCTGTGTTCTGATAGACGCCC	0.562000													69	90					0	0	0.048971	0	0
ROR1	4919	broad.mit.edu	37	1	64515390	64515390	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:64515390T>A	ENST00000371079.1	+	3	566	c.191T>A	c.(190-192)aTg>aAg	p.M64K	ROR1_ENST00000482426.1_3'UTR|ROR1_ENST00000371080.1_Missense_Mutation_p.M64K	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	64	Ig-like C2-type.				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						GATGAACCAATGAATAACATC	0.537000													53	149					0	0	0.048971	0	0
SELL	6402	broad.mit.edu	37	1	169677935	169677935	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:169677935G>T	ENST00000236147.4	-	3	294	c.134C>A	c.(133-135)gCa>gAa	p.A45E	C1orf112_ENST00000498289.1_Intron|SELL_ENST00000463108.1_5'UTR	NM_000655.4	NP_000646.2	P14151	LYAM1_HUMAN	selectin L	32					blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	15	all_hematologic(923;0.208)					TCCATGATGTGCCAGGAAATC	0.428000													6	16					4.096e-09	5.18373e-09	0.021553	1	0
CNR1	1268	broad.mit.edu	37	6	88854039	88854039	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:88854039T>A	ENST00000537554.1	-	2	4517	c.955A>T	c.(955-957)Atc>Ttc	p.I319F	CNR1_ENST00000535130.1_Missense_Mutation_p.I319F|CNR1_ENST00000428600.2_Missense_Mutation_p.I319F|CNR1_ENST00000549716.1_Missense_Mutation_p.I258F|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000369501.2_Missense_Mutation_p.I319F|CNR1_ENST00000369499.2_Missense_Mutation_p.I319F|CNR1_ENST00000549890.1_Missense_Mutation_p.I319F|CNR1_ENST00000468898.1_Missense_Mutation_p.I286F	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	319					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	GACGTGTGGATGATGATGCTC	0.547000													25	48					0	0	0.034045	0	0
ZNF839	55778	broad.mit.edu	37	14	102792955	102792955	+	Silent	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr14:102792955C>T	ENST00000262236.5	+	2	929	c.574C>T	c.(574-576)Ctg>Ttg	p.L192L	ZNF839_ENST00000558850.1_Silent_p.L192L|ZNF839_ENST00000442396.2_Silent_p.L308L|ZNF839_ENST00000559185.1_Silent_p.L192L	NM_018335.4	NP_060805.3	A8K0R7	ZN839_HUMAN	zinc finger protein 839	192						intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19						GAGCTGCTCCCTGAGGCCCAA	0.478000													13	35					0	0	0.020292	0	0
USP19	10869	broad.mit.edu	37	3	49153944	49153944	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:49153944C>A	ENST00000453664.1	-	8	1511	c.1193G>T	c.(1192-1194)tGc>tTc	p.C398F	USP19_ENST00000417901.1_Missense_Mutation_p.C408F|USP19_ENST00000398888.2_Missense_Mutation_p.C307F|USP19_ENST00000398892.3_Missense_Mutation_p.C345F|USP19_ENST00000398896.1_Missense_Mutation_p.C113F|USP19_ENST00000398898.2_Missense_Mutation_p.C345F|USP19_ENST00000434032.2_Missense_Mutation_p.C408F	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	307					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGTGTCCCTGCAGATCTCCTT	0.542000													18	37					1.99824e-07	2.45751e-07	0.033300	1	0
SLIT3	6586	broad.mit.edu	37	5	168244331	168244331	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:168244331A>T	ENST00000519560.1	-	8	1186	c.767T>A	c.(766-768)gTg>gAg	p.V256E	SLIT3_ENST00000404867.3_Missense_Mutation_p.V256E|SLIT3_ENST00000332966.8_Missense_Mutation_p.V256E	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	256	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTCTTCTGCACATCCGCCAC	0.592000													12	22					0	0	0.105934	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72055488	72055488	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr14:72055488G>A	ENST00000555818.1	+	2	1247	c.899G>A	c.(898-900)cGc>cAc	p.R300H	SIPA1L1_ENST00000381232.3_Missense_Mutation_p.R300H|SIPA1L1_ENST00000358550.2_Missense_Mutation_p.R300H	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	300					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CGTAAATTGCGCAATGCCAAA	0.443000													4	85					0	0	0.009096	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156727536	156727536	+	Splice_Site	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:156727536A>T	ENST00000264424.8	+	14	1918		c.e14-1		GUCY1B3_ENST00000503520.1_Splice_Site|GUCY1B3_ENST00000505154.1_Splice_Site|GUCY1B3_ENST00000505764.1_Splice_Site|GUCY1B3_ENST00000513437.1_Splice_Site|GUCY1B3_ENST00000502959.1_Splice_Site|GUCY1B3_ENST00000507146.1_Splice_Site	NM_000857.2	NP_000848.1	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3						blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		TGCCTATTTAAGGAAACAAAG	0.388000													4	19					0	0	0.014758	0	0
OR4K17	390436	broad.mit.edu	37	14	20586108	20586108	+	Silent	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr14:20586108C>A	ENST00000315543.4	+	1	543	c.543C>A	c.(541-543)ctC>ctA	p.L181L		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CCTCATGGCTCTTGGGTCTCC	0.458000													33	53					3.80469e-20	5.37237e-20	0.041601	1	0
OPN3	23596	broad.mit.edu	37	1	241767797	241767797	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:241767797C>A	ENST00000366554.2	-	2	564	c.458G>T	c.(457-459)tGg>tTg	p.W153L	OPN3_ENST00000469376.1_5'UTR|OPN3_ENST00000331838.5_Intron	NM_014322.2	NP_055137.2	Q9H1Y3	OPN3_HUMAN	opsin 3	153					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|visual perception	integral to plasma membrane	G-protein coupled photoreceptor activity			endometrium(1)|large_intestine(5)|lung(5)	11	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CCTCCAGGCCCAGGAAAAATT	0.537000													12	50					0.000151284	0.000170265	0.105934	1	0
TGFBR2	7048	broad.mit.edu	37	3	30686295	30686295	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:30686295T>C	ENST00000295754.5	+	2	533	c.151T>C	c.(151-153)Tgt>Cgt	p.C51R	TGFBR2_ENST00000359013.4_Missense_Mutation_p.C76R	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	51					activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						TCCACAACTGTGTAAATTTTG	0.423000													19	30					0	0	0.055883	0	0
PRKACB	5567	broad.mit.edu	37	1	84668410	84668410	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:84668410C>G	ENST00000370689.2	+	8	951	c.687C>G	c.(685-687)atC>atG	p.I229M	PRKACB_ENST00000370688.3_Missense_Mutation_p.I229M|PRKACB_ENST00000370685.3_Missense_Mutation_p.I276M|PRKACB_ENST00000370682.3_Missense_Mutation_p.I233M|PRKACB_ENST00000370680.1_Missense_Mutation_p.I235M|PRKACB_ENST00000394839.2_Missense_Mutation_p.I199M|PRKACB_ENST00000394838.2_Missense_Mutation_p.I236M	NM_001242862.1|NM_002731.2	NP_001229791.1|NP_002722.1	P22694	KAPCB_HUMAN	protein kinase, cAMP-dependent, catalytic, beta	229	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|regulation of insulin secretion|synaptic transmission|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|magnesium ion binding|protein binding			breast(1)|endometrium(2)|kidney(1)|lung(11)|ovary(1)	16				all cancers(265;0.00536)|Epithelial(280;0.0161)|OV - Ovarian serous cystadenocarcinoma(397;0.141)		GAGTGCTAATCTATGAAATGG	0.368000													6	109					0	0	0.069234	0	0
PCLO	27445	broad.mit.edu	37	7	82585848	82585848	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:82585848T>C	ENST00000423517.2	-	5	4758	c.4421A>G	c.(4420-4422)gAa>gGa	p.E1474G	PCLO_ENST00000333891.8_Missense_Mutation_p.E1474G	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1405					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GTCTTTCCTTTCTTCTTGACT	0.363000													25	49					0	0	0.108266	0	0
OR5D18	219438	broad.mit.edu	37	11	55587309	55587309	+	Silent	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:55587309C>G	ENST00000333976.4	+	1	224	c.204C>G	c.(202-204)tcC>tcG	p.S68S		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				GCCAACTCTCCTTTGTGGATT	0.413000													44	128					0	0	0.039052	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862844	10862844	+	RNA	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr21:10862844C>A	ENST00000559480.1	+	0	140																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						TCTGGATACACCATCACCAGC	0.577000													28	154					3.99451e-17	5.53784e-17	0.041601	1	0
EHMT1	79813	broad.mit.edu	37	9	140693353	140693353	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:140693353A>T	ENST00000460843.1	+	17	2621	c.2594A>T	c.(2593-2595)gAc>gTc	p.D865V		NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	865					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GGACAGATGGACGTCAACTGT	0.552000													19	39					0	0	0.049695	0	0
GRIN2B	2904	broad.mit.edu	37	12	13717204	13717204	+	Silent	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:13717204G>T	ENST00000279593.3	-	13	3177	c.2968C>A	c.(2968-2970)Cgg>Agg	p.R990R		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	990					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTATGGGGCCGGTGGTGATGG	0.552000													22	51					9.95505e-16	1.35549e-15	0.069288	1	0
INSRR	3645	broad.mit.edu	37	1	156812204	156812204	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:156812204G>A	ENST00000368195.3	-	18	3619	c.3223C>T	c.(3223-3225)Cgg>Tgg	p.R1075W	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	1075	Protein kinase.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCCTCAGGCCGCAAAGATCGA	0.602000													4	182					0	0	0.009096	0	0
RYR2	6262	broad.mit.edu	37	1	237947057	237947057	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:237947057A>T	ENST00000366574.2	+	90	12362	c.12045A>T	c.(12043-12045)aaA>aaT	p.K4015N	RYR2_ENST00000360064.6_Missense_Mutation_p.K4021N|RYR2_ENST00000542537.1_Missense_Mutation_p.K3999N	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4015					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGATTCTCAAATTTTTTGACA	0.403000													9	24					0	0	0.069234	0	0
DST	667	broad.mit.edu	37	6	56371575	56371575	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:56371575C>G	ENST00000370754.5	-	76	19158	c.19159G>C	c.(19159-19161)Gaa>Caa	p.E6387Q	DST_ENST00000340834.4_5'UTR|DST_ENST00000421834.2_Missense_Mutation_p.E4121Q|DST_ENST00000370788.2_Missense_Mutation_p.E4012Q|DST_ENST00000446842.2_Missense_Mutation_p.E5883Q|DST_ENST00000361203.3_Missense_Mutation_p.E6098Q|DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Missense_Mutation_p.E3795Q|DST_ENST00000370769.4_Missense_Mutation_p.E6209Q			Q03001	DYST_HUMAN	dystonin	6207					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CCATCTATTTCTTCCCTTATG	0.368000													26	56					0	0	0.034045	0	0
SPAG17	200162	broad.mit.edu	37	1	118693248	118693248	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:118693248T>C	ENST00000336338.5	-	3	298	c.233A>G	c.(232-234)aAt>aGt	p.N78S		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	78						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ATTTATTTCATTAATCTGTAA	0.284000													5	20					0	0	0.014758	0	0
SEC63	11231	broad.mit.edu	37	6	108227934	108227934	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:108227934T>C	ENST00000369002.4	-	9	960	c.781A>G	c.(781-783)Aat>Gat	p.N261D		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	261	SEC63 1.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		GCATCTTTATTATACTGAGGA	0.343000													32	81					0	0	0.050027	0	0
IGSF9	57549	broad.mit.edu	37	1	159897588	159897588	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:159897588G>A	ENST00000368094.1	-	20	3517	c.3320C>T	c.(3319-3321)gCc>gTc	p.A1107V	IGSF9_ENST00000361509.3_Missense_Mutation_p.A1091V|IGSF9_ENST00000493195.1_5'UTR	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	1107						cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			CCGGGAGCTGGCCAAGCCCAG	0.577000													4	85					0	0	0.009096	0	0
ALMS1	7840	broad.mit.edu	37	2	73677777	73677777	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:73677777A>G	ENST00000264448.6	+	8	4231	c.4120A>G	c.(4120-4122)Act>Gct	p.T1374A	ALMS1_ENST00000409009.1_Missense_Mutation_p.T1332A|ALMS1_ENST00000377715.1_Missense_Mutation_p.T1374A	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1374	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole		p.T1374A(1)		breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						TGGCACACCAACTGTAACCTC	0.443000													3	54					0	0	0.004672	0	0
TMEM190	147744	broad.mit.edu	37	19	55889560	55889560	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:55889560G>C	ENST00000291934.3	+	5	541	c.523G>C	c.(523-525)Gag>Cag	p.E175Q		NM_139172.1	NP_631911.1	Q8WZ59	TM190_HUMAN	transmembrane protein 190	175	Poly-Glu.					integral to membrane				large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	5	Breast(117;0.191)		BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		gggcgaggaagaggaggatta	0.637000													24	35					0	0	0.091800	0	0
ZSWIM3	140831	broad.mit.edu	37	20	44506136	44506136	+	Silent	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:44506136C>T	ENST00000255152.2	+	2	1148	c.939C>T	c.(937-939)ctC>ctT	p.L313L	ZSWIM3_ENST00000454862.2_Silent_p.L307L	NM_080752.3	NP_542790.2	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM-type containing 3	313							zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	35		Myeloproliferative disorder(115;0.0122)				CAACCCGACTCTTGGAGAAGA	0.522000													9	57					0	0	0.058154	0	0
NR5A2	2494	broad.mit.edu	37	1	200017310	200017310	+	Silent	SNP	C	C	T	rs151039307		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:200017310C>T	ENST00000367362.3	+	5	720	c.474C>T	c.(472-474)gcC>gcT	p.A158A	NR5A2_ENST00000544748.1_Silent_p.A86A|NR5A2_ENST00000236914.3_Silent_p.A112A	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	158					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					CTGTAAGGGCCGACCGAATGC	0.463000													13	52					0	0	0.105934	0	0
MYH13	8735	broad.mit.edu	37	17	10209812	10209812	+	Silent	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:10209812C>T	ENST00000418404.3	-	36	5593	c.5430G>A	c.(5428-5430)aaG>aaA	p.K1810K	MYH13_ENST00000252172.4_Silent_p.K1810K|MYH13_ENST00000570743.1_Silent_p.K1810K			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1810					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TCTTCCCGCCCTTCAGCGCCA	0.552000													50	135					0	0	0.048971	0	0
PANX1	24145	broad.mit.edu	37	11	93886744	93886744	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:93886744A>G	ENST00000227638.3	+	2	654	c.269A>G	c.(268-270)cAg>cGg	p.Q90R	PANX1_ENST00000436171.2_Missense_Mutation_p.Q90R	NM_015368.3	NP_056183.2	Q96RD7	PANX1_HUMAN	pannexin 1	90					positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding			endometrium(2)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GCTGTTCAGCAGAAGAACTCA	0.463000													5	27					0	0	0.029380	0	0
ACSS1	84532	broad.mit.edu	37	20	24994697	24994697	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:24994697A>T	ENST00000537502.1	-	7	2634	c.1103T>A	c.(1102-1104)aTc>aAc	p.I368N	ACSS1_ENST00000542618.1_Missense_Mutation_p.I330N|ACSS1_ENST00000432802.2_Missense_Mutation_p.I451N|ACSS1_ENST00000323482.4_Missense_Mutation_p.I451N			Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	451					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGCGATGCAGATGCCACCTGT	0.577000													4	9					0	0	0.021553	0	0
MYH6	4624	broad.mit.edu	37	14	23858085	23858085	+	Silent	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr14:23858085C>T	ENST00000405093.3	-	29	4228	c.4158G>A	c.(4156-4158)gaG>gaA	p.E1386E	MYH6_ENST00000356287.3_Silent_p.E1386E	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1386					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CTTCGAGCTCCTCAGTCCGCT	0.617000													29	62					0	0	0.041601	0	0
KCNJ3	3760	broad.mit.edu	37	2	155566162	155566162	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:155566162A>T	ENST00000295101.2	+	2	1227	c.750A>T	c.(748-750)gaA>gaT	p.E250D	KCNJ3_ENST00000493505.1_3'UTR|KCNJ3_ENST00000544049.1_Intron	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	250					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	ACCAACTTGAACTGGATGTAG	0.453000													10	59					0	0	0.069234	0	0
MT-ND1	4535	broad.mit.edu	37	MT	3380	3380	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrM:3380G>A	ENST00000361390.2	+	1	74	c.74G>A	c.(73-75)cGa>cAa	p.25_25insQ						mitochondrially encoded NADH dehydrogenase 1											breast(1)|endometrium(13)|kidney(17)|lung(2)|prostate(1)	34						GCTTACCGAACGAAAAATTCT	0.463000													13	818					0	0	0.105934	0	0
TRIM51HP	440041	broad.mit.edu	37	11	55065043	55065043	+	RNA	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:55065043G>T	ENST00000526016.1	-	0	382					NR_038174.2																						TTTTTTTTAGGAGCTCCTCCT	0.393000													7	19					0.00198382	0.00217649	0.029380	1	0
NRP2	8828	broad.mit.edu	37	2	206590699	206590699	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:206590699G>T	ENST00000360409.3	+	6	1674	c.883G>T	c.(883-885)Gcc>Tcc	p.A295S	NRP2_ENST00000357118.4_Missense_Mutation_p.A295S|NRP2_ENST00000540841.1_Missense_Mutation_p.A295S|NRP2_ENST00000540178.1_Missense_Mutation_p.A295S|NRP2_ENST00000417189.1_Missense_Mutation_p.A295S|NRP2_ENST00000355117.4_Missense_Mutation_p.A295S|NRP2_ENST00000272849.3_Missense_Mutation_p.A295S|NRP2_ENST00000412873.2_Missense_Mutation_p.A295S|NRP2_ENST00000357785.5_Missense_Mutation_p.A295S	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	295	F5/8 type C 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						ACAGATCAGTGCCTCATCTAC	0.527000													10	48					0.00829132	0.00896756	0.069234	1	0
OR10Q1	219960	broad.mit.edu	37	11	57995621	57995621	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:57995621A>G	ENST00000316770.2	-	1	769	c.727T>C	c.(727-729)Ttc>Ctc	p.F243L		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				CAGGTGGAGAAGGCCCGGCGG	0.632000													9	38					0	0	0.028581	0	0
UBOX5	22888	broad.mit.edu	37	20	3095974	3095974	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:3095974G>T	ENST00000217173.2	-	4	1865	c.1394C>A	c.(1393-1395)tCc>tAc	p.S465Y	UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000348031.2_Intron	NM_001267584.1|NM_014948.3	NP_001254513.1|NP_055763.1	O94941	RNF37_HUMAN	U-box domain containing 5	465						nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	20						AGGCCTCCAGGAAGTGTTGCT	0.612000											OREG0025729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	30					0.0381472	0.0397096	0.038147	1	0
OBSCN	84033	broad.mit.edu	37	1	228509046	228509046	+	Splice_Site	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:228509046T>C	ENST00000570156.2	+	66	17449	c.17373_splice	c.e66-1	p.V5792_splice	OBSCN_ENST00000422127.1_Splice_Site_p.V4835_splice|OBSCN_ENST00000366707.4_Splice_Site_p.V2469_splice|OBSCN_ENST00000366709.4_Splice_Site_p.V1954_splice|OBSCN_ENST00000284548.11_Splice_Site_p.V4835_splice	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4835	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGCCCACAGGTTGGGGCCCCA	0.632000													3	3					0	0	0.009096	0	0
TAF1A	9015	broad.mit.edu	37	1	222742739	222742739	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:222742739T>C	ENST00000543857.1	-	8	1130	c.922A>G	c.(922-924)Agt>Ggt	p.S308G	TAF1A_ENST00000350027.4_Intron|TAF1A_ENST00000391882.1_Intron|TAF1A_ENST00000366890.1_Intron|TAF1A_ENST00000352967.4_Intron			Q15573	TAF1A_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	0					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	RNA polymerase I transcription factor complex	DNA binding			kidney(3)|large_intestine(3)|lung(11)|urinary_tract(1)	18				GBM - Glioblastoma multiforme(131;0.0186)		CTCAGTGTACTGTACATTATT	0.418000													4	15					0	0	0.009096	0	0
RBM48	84060	broad.mit.edu	37	7	92158932	92158932	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:92158932A>C	ENST00000481551.1	+	2	295	c.254A>C	c.(253-255)gAc>gCc	p.D85A	RBM48_ENST00000265732.5_Missense_Mutation_p.D85A			Q5RL73	CG064_HUMAN	RNA binding motif protein 48	85							nucleotide binding										CCAGCAGAAGACTTTACTGAA	0.358000													6	14					0	0	0.029380	0	0
C17orf97	400566	broad.mit.edu	37	17	263456	263456	+	Silent	SNP	T	T	C	rs71369086		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:263456T>C	ENST00000360127.6	+	2	838	c.822T>C	c.(820-822)ggT>ggC	p.G274G	AC108004.3_ENST00000466740.2_RNA|C17orf97_ENST00000571106.1_Intron	NM_001013672.4	NP_001013694.4	Q6ZQX7	CQ097_HUMAN	chromosome 17 open reading frame 97	304	20 X 10 AA approximative tandem repeat of A-L-K-G-F-H-P-D-P-E.									breast(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)	14						CCCTCAAGGGTTTCCACACTG	0.682000													3	15					0	0	0.004672	0	0
COPB1	1315	broad.mit.edu	37	11	14496148	14496148	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:14496148C>A	ENST00000249923.3	-	14	1930	c.1630G>T	c.(1630-1632)Gga>Tga	p.G544*	COPB1_ENST00000439561.2_Nonsense_Mutation_p.G544*|COPB1_ENST00000526191.1_5'UTR	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	544					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						AGAAGGAATCCTCTCAAGGGA	0.433000													22	124					3.62473e-10	4.72454e-10	0.062417	1	0
ATP1A4	480	broad.mit.edu	37	1	160143392	160143392	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:160143392C>A	ENST00000368081.4	+	13	2347	c.1876C>A	c.(1876-1878)Cat>Aat	p.H626N	ATP1A4_ENST00000418334.1_3'UTR	NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	626					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AACAGGAGATCATCCCATTAC	0.522000													40	115					3.54909e-21	5.08203e-21	0.042209	1	0
CCDC172	374355	broad.mit.edu	37	10	118138001	118138001	+	Silent	SNP	A	A	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:118138001A>G	ENST00000333254.3	+	8	971	c.720A>G	c.(718-720)acA>acG	p.T240T		NM_198515.2	NP_940917.1			coiled-coil domain containing 172																		CTCTCCAAACAGAAATAGAAT	0.289000													5	6					0	0	0.014758	0	0
WDR16	146845	broad.mit.edu	37	17	9538770	9538770	+	Missense_Mutation	SNP	C	C	A	rs140517505	byFrequency	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:9538770C>A	ENST00000352665.5	+	11	1438	c.1369C>A	c.(1369-1371)Ctg>Atg	p.L457M	WDR16_ENST00000396219.3_Missense_Mutation_p.L389M|WDR16_ENST00000576714.1_3'UTR|WDR16_ENST00000299764.5_Missense_Mutation_p.L467M	NM_145054.4	NP_659491.4	Q8N1V2	WDR16_HUMAN	WD repeat domain 16	457						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31						GGAGGAGGCCCTGAAGGAACA	0.537000													11	21					1.58986e-06	1.90909e-06	0.069234	1	0
C6orf222	389384	broad.mit.edu	37	6	36287308	36287308	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:36287308C>A	ENST00000437635.2	-	11	1925	c.1748G>T	c.(1747-1749)cGc>cTc	p.R583L		NM_001010903.4	NP_001010903.3	P0C671	CF222_HUMAN	chromosome 6 open reading frame 222	583										breast(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(4)|urinary_tract(4)	26						CACCTGGCTGCGCAGGGTGGC	0.532000													17	82					2.4624e-09	3.1293e-09	0.049695	1	0
PPAT	5471	broad.mit.edu	37	4	57301533	57301533	+	Silent	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:57301533G>C	ENST00000264220.2	-	1	248	c.111C>G	c.(109-111)ctC>ctG	p.L37L		NM_002703.4	NP_002694.3	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	37	Glutamine amidotransferase type-2.				glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding			cervix(1)|endometrium(2)|large_intestine(6)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	20	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	GCAGCCCCACGAGTCCCAGAG	0.657000													6	31					0	0	0.029380	0	0
UPF2	26019	broad.mit.edu	37	10	12043820	12043820	+	Silent	SNP	T	T	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:12043820T>A	ENST00000356352.2	-	5	1982	c.1509A>T	c.(1507-1509)gcA>gcT	p.A503A	UPF2_ENST00000357604.5_Silent_p.A503A|UPF2_ENST00000397053.2_Silent_p.A503A			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	503					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				TAGATTCTTTTGCCTCTGTTG	0.353000													3	9					0	0	0.004672	0	0
COL4A1	1282	broad.mit.edu	37	13	110814736	110814736	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr13:110814736C>A	ENST00000375820.4	-	48	4424	c.4303G>T	c.(4303-4305)Ggg>Tgg	p.G1435W	COL4A1_ENST00000467182.1_5'UTR	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1435	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTGGGGGCCCCATGGATCCT	0.512000													90	141					5.19266e-41	7.72567e-41	0.048971	1	0
NRP2	8828	broad.mit.edu	37	2	206590698	206590698	+	Silent	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:206590698T>C	ENST00000360409.3	+	6	1673	c.882T>C	c.(880-882)agT>agC	p.S294S	NRP2_ENST00000357118.4_Silent_p.S294S|NRP2_ENST00000540841.1_Silent_p.S294S|NRP2_ENST00000540178.1_Silent_p.S294S|NRP2_ENST00000417189.1_Silent_p.S294S|NRP2_ENST00000355117.4_Silent_p.S294S|NRP2_ENST00000272849.3_Silent_p.S294S|NRP2_ENST00000412873.2_Silent_p.S294S|NRP2_ENST00000357785.5_Silent_p.S294S	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	294	F5/8 type C 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						AACAGATCAGTGCCTCATCTA	0.527000													10	47					0	0	0.069234	0	0
EDAR	10913	broad.mit.edu	37	2	109513583	109513583	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:109513583T>G	ENST00000409271.1	-	12	1666	c.1223A>C	c.(1222-1224)cAc>cCc	p.H408P	EDAR_ENST00000376651.1_Missense_Mutation_p.H408P|EDAR_ENST00000258443.2_Missense_Mutation_p.H376P			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	376	Death.		I -> F (in EDA).		apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						CTCGGCGAGGTGGCGCCACGT	0.572000													15	40					0	0	0.043863	0	0
DENND2C	163259	broad.mit.edu	37	1	115151428	115151428	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:115151428T>A	ENST00000393274.1	-	10	2061	c.1436A>T	c.(1435-1437)gAg>gTg	p.E479V	DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393276.3_Missense_Mutation_p.E422V|DENND2C_ENST00000393277.1_Missense_Mutation_p.E479V	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	479										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAGATCCCGCTCCAAGGTCTG	0.433000													10	25					0	0	0.058154	0	0
ZNF831	128611	broad.mit.edu	37	20	57769599	57769599	+	Silent	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:57769599C>A	ENST00000371030.2	+	1	3525	c.3525C>A	c.(3523-3525)ccC>ccA	p.P1175P		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1175						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					ACCCCTTTCCCTCACTGAAGG	0.662000													12	24					2.27111e-07	2.78188e-07	0.093190	1	0
SEMG1	6406	broad.mit.edu	37	20	43836133	43836133	+	Silent	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:43836133T>C	ENST00000372781.3	+	2	252	c.195T>C	c.(193-195)atT>atC	p.I65I	SEMG1_ENST00000244069.6_Silent_p.I65I	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GTTTTTCTATTCAATACACAT	0.398000													8	74					0	0	0.038147	0	0
WDR73	84942	broad.mit.edu	37	15	85197493	85197493	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:85197493C>A	ENST00000434634.2	-	1	73	c.13G>T	c.(13-15)Gac>Tac	p.D5Y	WDR73_ENST00000398528.3_5'UTR	NM_032856.2	NP_116245.2	Q6P4I2	WDR73_HUMAN	WD repeat domain 73	5										cervix(1)|large_intestine(1)|lung(1)	3						AGCCAGTCGTCCCCAGGATCC	0.677000													16	43					2.12542e-12	2.80628e-12	0.030593	1	0
KCTD19	146212	broad.mit.edu	37	16	67354623	67354623	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr16:67354623C>G	ENST00000304372.5	-	2	224	c.169G>C	c.(169-171)Gac>Cac	p.D57H	KCTD19_ENST00000562860.1_5'UTR	NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	57	BTB 1.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CCATCTCTGTCGATAAATAGC	0.478000													9	35					0	0	0.047766	0	0
COL27A1	85301	broad.mit.edu	37	9	116931659	116931659	+	Silent	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:116931659C>A	ENST00000356083.3	+	3	2215	c.1824C>A	c.(1822-1824)ggC>ggA	p.G608G		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	608	Pro-rich.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						CGAGCAGTGGCTATTCGATCT	0.657000													7	16					2.17888e-05	2.50776e-05	0.058154	1	0
ZNF709	163051	broad.mit.edu	37	19	12575977	12575977	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:12575977T>G	ENST00000397732.3	-	4	930	c.759A>C	c.(757-759)gaA>gaC	p.E253D	CTD-3105H18.18_ENST00000598753.1_Intron|ZNF709_ENST00000428311.1_Missense_Mutation_p.E253D	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	253					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						ATTGTTTACATTCATAGGGTT	0.383000													14	22					0	0	0.020292	0	0
HTR5A	3361	broad.mit.edu	37	7	154876127	154876127	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:154876127C>A	ENST00000287907.2	+	2	1580	c.1004C>A	c.(1003-1005)cCc>cAc	p.P335H	HTR5A_ENST00000486819.1_3'UTR	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	335						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TTCTTTAACCCCCTGATCTAT	0.483000													29	70					3.17567e-06	3.76879e-06	0.037714	1	0
PRMT6	55170	broad.mit.edu	37	1	107600087	107600087	+	Silent	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:107600087G>T	ENST00000361318.5	+	1	821	c.573G>T	c.(571-573)ccG>ccT	p.P191P	PRMT6_ENST00000370078.1_Silent_p.P250P	NM_018137.2	NP_060607.2	Q96LA8	ANM6_HUMAN	protein arginine methyltransferase 6	250					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			biliary_tract(1)|breast(2)|kidney(1)|large_intestine(4)|lung(5)|urinary_tract(1)	14		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		TGGCCCGGCCGCAGCGCTTTG	0.692000													14	35					1.49906e-05	1.74509e-05	0.020292	1	0
LRRC7	57554	broad.mit.edu	37	1	70478656	70478656	+	Splice_Site	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:70478656G>C	ENST00000310961.5	+	14	1453		c.e14-1		LRRC7_ENST00000035383.5_Splice_Site|LRRC7_ENST00000415775.2_Splice_Site			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7							centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GTTACCTACAGATTGGAAGTT	0.279000													6	35					0	0	0.021553	0	0
ATR	545	broad.mit.edu	37	3	142281289	142281289	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:142281289T>A	ENST00000350721.4	-	4	1076	c.955A>T	c.(955-957)Aat>Tat	p.N319Y	ATR_ENST00000383101.3_Missense_Mutation_p.N319Y	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	319					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						AGCAGCATATTTAAATAGACA	0.378000								Other conserved DNA damage response genes					11	18					0	0	0.093190	0	0
UNC13A	23025	broad.mit.edu	37	19	17785516	17785516	+	Silent	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:17785516C>G	ENST00000428389.2	-	4	365	c.366G>C	c.(364-366)acG>acC	p.T122T	UNC13A_ENST00000552293.1_Silent_p.T34T|UNC13A_ENST00000519716.2_Silent_p.T34T|UNC13A_ENST00000551649.1_Silent_p.T34T|UNC13A_ENST00000252773.7_Silent_p.T34T|UNC13A_ENST00000550896.1_Silent_p.T34T			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	34					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CCGCGATGGTCGTGCTCTTGA	0.587000													13	31					0	0	0.093190	0	0
PHKA2	5256	broad.mit.edu	37	X	18926946	18926946	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:18926946T>C	ENST00000379942.4	-	21	2998	c.2333A>G	c.(2332-2334)gAc>gGc	p.D778G		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	778					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					GTACAGAATGTCTGCTTGGTC	0.428000													21	55					0	0	0.062417	0	0
POPDC3	64208	broad.mit.edu	37	6	105607676	105607676	+	Silent	SNP	A	A	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:105607676A>G	ENST00000254765.3	-	3	782	c.504T>C	c.(502-504)gaT>gaC	p.D168D	POPDC3_ENST00000474760.1_5'UTR|BVES-AS1_ENST00000369122.3_RNA|BVES-AS1_ENST00000580854.1_RNA|BVES-AS1_ENST00000580511.1_RNA	NM_022361.4	NP_071756.2	Q9HBV1	POPD3_HUMAN	popeye domain containing 3	168						integral to membrane				NS(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(3)|urinary_tract(1)	26		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				GAAATTCGCCATCAACTGTCA	0.458000													9	23					0	0	0.069234	0	0
RIF1	55183	broad.mit.edu	37	2	152320281	152320281	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:152320281G>T	ENST00000243326.4	+	29	4730	c.4247G>T	c.(4246-4248)cGg>cTg	p.R1416L	RIF1_ENST00000430328.2_Missense_Mutation_p.R1416L|RIF1_ENST00000428287.2_Missense_Mutation_p.R1416L|RIF1_ENST00000444746.2_Missense_Mutation_p.R1416L|RIF1_ENST00000453091.2_Missense_Mutation_p.R1416L			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	1416					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		ACCCTTAGACGGTCTTCAAGG	0.393000													5	35					0.014758	0.015575	0.014758	1	0
OR11L1	391189	broad.mit.edu	37	1	248004584	248004584	+	Silent	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:248004584G>T	ENST00000355784.2	-	1	670	c.615C>A	c.(613-615)gcC>gcA	p.A205A		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGCACAGCACGGCAATTGACA	0.473000													43	124					2.95478e-19	4.15303e-19	0.104719	1	0
MUC7	4589	broad.mit.edu	37	4	71347033	71347033	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:71347033C>T	ENST00000413702.1	+	4	860	c.572C>T	c.(571-573)gCc>gTc	p.A191V	MUC7_ENST00000456088.1_Missense_Mutation_p.A191V|MUC7_ENST00000304887.5_Missense_Mutation_p.A191V	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	191	Thr-rich.					extracellular region	protein binding	p.A191V(1)		central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACCACAGCTGCCCCACCCACA	0.587000													4	130					0	0	0.021553	0	0
SLC40A1	30061	broad.mit.edu	37	2	190428759	190428759	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:190428759T>C	ENST00000261024.2	-	7	1379	c.953A>G	c.(952-954)tAt>tGt	p.Y318C		NM_014585.5	NP_055400.1	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated transporter), member 1	318					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			GACAGTCATATAAAGGAAAGC	0.527000													6	27					0	0	0.038147	0	0
CPN1	1369	broad.mit.edu	37	10	101829549	101829549	+	Silent	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:101829549G>T	ENST00000370418.3	-	3	749	c.498C>A	c.(496-498)ctC>ctA	p.L166L		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	166	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		TATAGGTATTGAGATCAGGGA	0.463000													26	40					5.09552e-08	6.3694e-08	0.045705	1	0
ZNF536	9745	broad.mit.edu	37	19	30935619	30935619	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:30935619G>T	ENST00000355537.3	+	2	1297	c.1150G>T	c.(1150-1152)Gag>Tag	p.E384*		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GCGCTTCAAGGAGCCCTGGTT	0.607000													31	50					2.61193e-14	3.49403e-14	0.041601	1	0
DNAAF3	352909	broad.mit.edu	37	19	55670944	55670944	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:55670944C>T	ENST00000527223.2	-	11	1397	c.1396G>A	c.(1396-1398)Gcc>Acc	p.A466T	DNAAF3_ENST00000587789.2_5'UTR|DNAAF3_ENST00000391720.4_Missense_Mutation_p.A446T|DNAAF3_ENST00000455045.1_Missense_Mutation_p.A345T|CTD-2587H24.5_ENST00000591665.1_RNA|CTD-2587H24.4_ENST00000587871.1_Missense_Mutation_p.G60D|DNAAF3_ENST00000524407.2_Missense_Mutation_p.A399T	NM_001256714.1	NP_001243643.1	Q8N9W5	CS051_HUMAN	dynein, axonemal, assembly factor 3	399																	GCCACACAGGCCCCAAGCTCA	0.587000													38	42					0	0	0.111260	0	0
SLITRK3	22865	broad.mit.edu	37	3	164907125	164907125	+	Silent	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:164907125T>C	ENST00000475390.1	-	2	1937	c.1494A>G	c.(1492-1494)gcA>gcG	p.A498A	SLITRK3_ENST00000241274.3_Silent_p.A498A			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	498						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						GGCTGAAGGCTGCAGGCTGGA	0.512000										HNSCC(40;0.11)			12	71					0	0	0.093190	0	0
RSPO4	343637	broad.mit.edu	37	20	948637	948637	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:948637G>T	ENST00000217260.4	-	2	320	c.224C>A	c.(223-225)cCt>cAt	p.P75H	RSPO4_ENST00000400634.2_Missense_Mutation_p.P75H	NM_001029871.3	NP_001025042.2	Q2I0M5	RSPO4_HUMAN	R-spondin 4	75					Wnt receptor signaling pathway	extracellular region	heparin binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						GAAGTACCCAGGGGGACAGTC	0.602000													45	99					5.22555e-25	7.55353e-25	0.048971	1	0
DSG2	1829	broad.mit.edu	37	18	29122617	29122617	+	Silent	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr18:29122617C>T	ENST00000261590.8	+	14	2345	c.2136C>T	c.(2134-2136)tcC>tcT	p.S712S	RP11-75N4.2_ENST00000583706.1_RNA	NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	712					cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			ATGAGATGTCCGAGATGGATG	0.507000													19	62					0	0	0.049695	0	0
NINL	22981	broad.mit.edu	37	20	25485523	25485523	+	Splice_Site	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:25485523C>A	ENST00000278886.6	-	6	782		c.e6+1		NINL_ENST00000422516.1_Splice_Site	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like						G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						GTGCCCCTCACCTCTTTCTCG	0.622000													3	10					0.00909568	0.00969994	0.009096	1	0
CCDC172	374355	broad.mit.edu	37	10	118138000	118138000	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:118138000C>A	ENST00000333254.3	+	8	970	c.719C>A	c.(718-720)aCa>aAa	p.T240K		NM_198515.2	NP_940917.1			coiled-coil domain containing 172																		GCTCTCCAAACAGAAATAGAA	0.289000													5	6					0.000602214	0.000670348	0.014758	1	0
SAAL1	113174	broad.mit.edu	37	11	18112007	18112007	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:18112007G>C	ENST00000524803.1	-	5	496	c.447C>G	c.(445-447)gaC>gaG	p.D149E	SAAL1_ENST00000300013.4_Missense_Mutation_p.D149E|SAAL1_ENST00000533851.1_5'UTR|SAAL1_ENST00000529318.1_Missense_Mutation_p.D149E			Q96ER3	SAAL1_HUMAN	serum amyloid A-like 1	149					acute-phase response	extracellular region	binding			breast(2)|large_intestine(5)|lung(8)	15						GAGTAGGTGGGTCTGAATCAT	0.323000													3	16					0	0	0.004672	0	0
SGSM1	129049	broad.mit.edu	37	22	25264768	25264768	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr22:25264768G>T	ENST00000400358.4	+	12	1294	c.1237G>T	c.(1237-1239)Gag>Tag	p.E413*	SGSM1_ENST00000400359.4_Nonsense_Mutation_p.E413*	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	413						Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						AGATGATGATGAGGCCACGGA	0.537000													15	78					3.45872e-05	3.96582e-05	0.028581	1	0
OR5M11	219487	broad.mit.edu	37	11	56310716	56310716	+	Silent	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:56310716G>T	ENST00000528616.2	-	1	41	c.18C>A	c.(16-18)ggC>ggA	p.G6G		NM_001005245.1	NP_001005245.1	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M, member 11	6					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)	18						TGATTGCACTGCCATTTGTGT	0.403000													25	71					4.87955e-14	6.47071e-14	0.108266	1	0
XIRP2	129446	broad.mit.edu	37	2	168103983	168103983	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:168103983G>T	ENST00000409195.1	+	9	6170	c.6081G>T	c.(6079-6081)aaG>aaT	p.K2027N	XIRP2_ENST00000409273.1_Missense_Mutation_p.K1805N|XIRP2_ENST00000295237.9_Missense_Mutation_p.K2027N|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1852					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GCACTGTAAAGATTGTCATAG	0.383000													17	45					2.4624e-09	3.1293e-09	0.049695	1	0
ZAN	7455	broad.mit.edu	37	7	100362997	100362997	+	RNA	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:100362997C>A	ENST00000542585.1	+	0	4438				ZAN_ENST00000546213.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CGCCCAACAGCAAGTACTCCC	0.597000													4	50					3.59834e-05	4.11046e-05	0.021553	1	0
SLC6A12	6539	broad.mit.edu	37	12	311924	311924	+	Missense_Mutation	SNP	T	T	C	rs144464466		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:311924T>C	ENST00000428720.1	-	5	1215	c.472A>G	c.(472-474)Aac>Gac	p.N158D	SLC6A12_ENST00000538272.1_5'UTR|SLC6A12_ENST00000359674.4_Missense_Mutation_p.N158D|SLC6A12_ENST00000397296.2_Missense_Mutation_p.N158D|SLC6A12_ENST00000424061.2_Missense_Mutation_p.N158D|SLC6A12_ENST00000536824.1_Missense_Mutation_p.N158D	NM_001122848.2	NP_001116320.1	P48065	S6A12_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 12	158					cellular nitrogen compound metabolic process|neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0172)|all_epithelial(11;0.0283)|all_lung(10;0.0392)|Lung NSC(10;0.0567)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00227)			CAAAAGTTGTTGCAGGTCGTC	0.527000													12	29					0	0	0.020292	0	0
MYO1D	4642	broad.mit.edu	37	17	30932130	30932130	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:30932130C>A	ENST00000318217.5	-	21	3143	c.2839G>T	c.(2839-2841)Gga>Tga	p.G947*	MYO1D_ENST00000394649.4_Nonsense_Mutation_p.G859*|MYO1D_ENST00000579584.1_Nonsense_Mutation_p.G947*	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	947						myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			ACCAGCACTCCAACAAGTTCT	0.383000													6	19					0.0215528	0.0225897	0.021553	1	0
PDP1	54704	broad.mit.edu	37	8	94935198	94935198	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:94935198C>T	ENST00000396200.3	+	3	1262	c.986C>T	c.(985-987)tCa>tTa	p.S329L	PDP1_ENST00000517764.1_Missense_Mutation_p.S304L|PDP1_ENST00000297598.4_Missense_Mutation_p.S304L|PDP1_ENST00000520728.1_Missense_Mutation_p.S304L	NM_001161779.1	NP_001155251.1	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 1	304					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18						GAGGACGGCTCATGGTCAGCA	0.517000													3	26					0	0	0.004672	0	0
CMYA5	202333	broad.mit.edu	37	5	79027236	79027236	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:79027236C>T	ENST00000446378.2	+	2	2679	c.2648C>T	c.(2647-2649)tCa>tTa	p.S883L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	883						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GTTGTTCTATCAGACGAAGAG	0.493000													4	69					0	0	0.009096	0	0
MUC16	94025	broad.mit.edu	37	19	9076923	9076923	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:9076923T>A	ENST00000397910.4	-	3	10726	c.10523A>T	c.(10522-10524)gAc>gTc	p.D3508V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3509	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGGGCAATGTCACTTTTCAC	0.512000													83	143					0	0	0.048971	0	0
GPR112	139378	broad.mit.edu	37	X	135432048	135432048	+	Silent	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:135432048T>C	ENST00000394143.1	+	6	6474	c.6183T>C	c.(6181-6183)tcT>tcC	p.S2061S	GPR112_ENST00000287534.4_Silent_p.S1998S|GPR112_ENST00000370652.1_Silent_p.S2061S|GPR112_ENST00000412101.1_Silent_p.S1856S|GPR112_ENST00000394141.1_Silent_p.S1856S	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2061					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CACTACCCTCTGCTACTATGA	0.438000													54	103					0	0	0.048971	0	0
DFNB31	25861	broad.mit.edu	37	9	117168637	117168637	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:117168637C>A	ENST00000362057.3	-	9	2402	c.2234G>T	c.(2233-2235)cGc>cTc	p.R745L	DFNB31_ENST00000374059.3_Missense_Mutation_p.R394L|DFNB31_ENST00000265134.6_Missense_Mutation_p.R362L	NM_001173425.1|NM_015404.3	NP_001166896.1|NP_056219.3	Q9P202	WHRN_HUMAN	deafness, autosomal recessive 31	745					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|ovary(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GTACTCACTGCGCGTCTGGGG	0.607000													15	31					1.01871e-10	1.33926e-10	0.049695	1	0
IKBIP	121457	broad.mit.edu	37	12	99019977	99019977	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:99019977C>G	ENST00000299157.4	-	3	1238	c.865G>C	c.(865-867)Gat>Cat	p.D289H	IKBIP_ENST00000342502.2_Intron|IKBIP_ENST00000393042.3_Intron|IKBIP_ENST00000420861.1_Intron	NM_153687.3	NP_710154.1	Q70UQ0	IKIP_HUMAN	IKBKB interacting protein	290					induction of apoptosis|response to X-ray	endoplasmic reticulum membrane|integral to membrane	protein binding			NS(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(2)	6						TCTATCAGATCCTGAGAGACT	0.373000													5	8					0	0	0.014758	0	0
ITPR2	3709	broad.mit.edu	37	12	26818887	26818887	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:26818887G>A	ENST00000381340.3	-	14	1923	c.1507C>T	c.(1507-1509)Cga>Tga	p.R503*		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	503					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					TGACGCTCTCGGTTTGGCTTA	0.338000													6	20					0	0	0.038147	0	0
TRIM54	57159	broad.mit.edu	37	2	27521582	27521582	+	Missense_Mutation	SNP	G	G	A	rs140219939		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:27521582G>A	ENST00000296098.4	+	2	586	c.316G>A	c.(316-318)Gac>Aac	p.D106N	TRIM54_ENST00000380075.2_Missense_Mutation_p.D106N	NM_032546.3	NP_115935.3	Q9BYV2	TRI54_HUMAN	tripartite motif containing 54	106					cell differentiation|microtubule-based process|multicellular organismal development|negative regulation of microtubule depolymerization	microtubule|sarcomere	signal transducer activity|zinc ion binding			cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAACATTATCGACATTTACAA	0.557000													7	16					0	0	0.029380	0	0
COL7A1	1294	broad.mit.edu	37	3	48607596	48607596	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:48607596G>A	ENST00000328333.8	-	98	7563	c.7456C>T	c.(7456-7458)Ccc>Tcc	p.P2486S	COL7A1_ENST00000454817.1_Missense_Mutation_p.P2454S	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2486	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCCTGGCCGGGGCGGCCATCT	0.592000													6	17					0	0	0.038147	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378149	31378149	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:31378149T>C	ENST00000297142.3	-	2	1056	c.734A>G	c.(733-735)gAa>gGa	p.E245G		NM_022728.2	NP_073565.2	Q96NK8	NDF6_HUMAN	neuronal differentiation 6	245					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	32						GGAAGTACTTTCATAGAAGGA	0.473000													15	54					0	0	0.024245	0	0
GALNT12	79695	broad.mit.edu	37	9	101599398	101599398	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:101599398C>G	ENST00000375011.3	+	6	1180	c.1180C>G	c.(1180-1182)Ctc>Gtc	p.L394V		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	394						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				ATTTAAAGAGCTCTACTACCA	0.542000													73	165					0	0	0.048971	0	0
SLC5A8	160728	broad.mit.edu	37	12	101577946	101577946	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:101577946G>C	ENST00000536262.2	-	8	1576	c.1018C>G	c.(1018-1020)Ctt>Gtt	p.L340V		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	340					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GCCACAAAAAGTCCAGGAAGT	0.358000													8	42					0	0	0.069234	0	0
OR8D2	283160	broad.mit.edu	37	11	124189502	124189502	+	Silent	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:124189502G>A	ENST00000357438.2	-	1	682	c.592C>T	c.(592-594)Ctg>Ttg	p.L198L		NM_001002918.1	NP_001002918.1	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D, member 2	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	25		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		ATGAACAGCAGAATCTCATTG	0.403000													32	80					0	0	0.041601	0	0
DNAH3	55567	broad.mit.edu	37	16	21051240	21051240	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr16:21051240A>G	ENST00000261383.3	-	33	4663	c.4664T>C	c.(4663-4665)aTg>aCg	p.M1555T	DNAH3_ENST00000415178.1_Missense_Mutation_p.M1555T	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1555	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		ATCTGGGACCATCATGGCCAC	0.478000													47	104					0	0	0.048971	0	0
LACC1	144811	broad.mit.edu	37	13	44455589	44455589	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr13:44455589A>T	ENST00000441843.1	+	2	953	c.468A>T	c.(466-468)gaA>gaT	p.E156D	LACC1_ENST00000325686.6_Missense_Mutation_p.E156D	NM_001128303.1	NP_001121775.1	Q8IV20	CM031_HUMAN	laccase (multicopper oxidoreductase) domain containing 1	156																	CAGCTCAAGAACTAAGAGGAA	0.338000													6	35					0	0	0.029380	0	0
FLG	2312	broad.mit.edu	37	1	152283678	152283678	+	Silent	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:152283678G>A	ENST00000368799.1	-	3	3719	c.3684C>T	c.(3682-3684)gaC>gaT	p.D1228D	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1228	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTGGAGCCGTCTCCTGATT	0.562000									Ichthyosis				124	211					0	0	0.048971	0	0
TNC	3371	broad.mit.edu	37	9	117848545	117848545	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:117848545C>T	ENST00000350763.4	-	3	1876	c.1465G>A	c.(1465-1467)Gac>Aac	p.D489N	TNC_ENST00000537320.1_Missense_Mutation_p.D489N|TNC_ENST00000345230.3_Missense_Mutation_p.D489N|TNC_ENST00000535648.1_Missense_Mutation_p.D489N|TNC_ENST00000341037.4_Missense_Mutation_p.D489N|TNC_ENST00000346706.3_Missense_Mutation_p.D489N|TNC_ENST00000340094.3_Missense_Mutation_p.D489N|TNC_ENST00000423613.2_Missense_Mutation_p.D489N|TNC_ENST00000542877.1_Missense_Mutation_p.D489N	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	489	EGF-like 11.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						GTGTAGCCGTCATCACAAACA	0.582000													32	96					0	0	0.039052	0	0
DNASE2B	58511	broad.mit.edu	37	1	84880433	84880433	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:84880433G>C	ENST00000370665.3	+	6	1001	c.968G>C	c.(967-969)gGa>gCa	p.G323A	DNASE2B_ENST00000370662.3_Missense_Mutation_p.G115A	NM_021233.2	NP_067056.2	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta	323					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		ACATGTATTGGAGACCTAAAT	0.393000													8	25					0	0	0.047766	0	0
LRRK2	120892	broad.mit.edu	37	12	40761466	40761466	+	Missense_Mutation	SNP	G	G	T	rs150062967		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:40761466G>T	ENST00000298910.7	+	51	7541	c.7483G>T	c.(7483-7485)Gtt>Ttt	p.V2495F		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2495					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding	p.V2495I(1)|p.V2502I(1)		NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTGCTTGACCGTTTGGGACAT	0.308000													4	11					0.014758	0.015575	0.014758	1	0
NT5C3A	51251	broad.mit.edu	37	7	33057180	33057180	+	Silent	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:33057180T>C	ENST00000396152.2	-	8	764	c.462A>G	c.(460-462)caA>caG	p.Q154Q	NT5C3A_ENST00000381626.2_Silent_p.Q142Q|NT5C3A_ENST00000242210.7_Silent_p.Q193Q|NT5C3A_ENST00000405342.1_Silent_p.Q154Q|NT5C3A_ENST00000409787.1_Silent_p.Q154Q|AVL9_ENST00000404479.1_Intron|NT5C3A_ENST00000409467.1_Silent_p.Q142Q	NM_016489.12	NP_057573.2			5'-nucleotidase, cytosolic IIIA																		TGCTATGTTGTTGGAGCTTAT	0.378000													10	44					0	0	0.080935	0	0
DOCK10	55619	broad.mit.edu	37	2	225709558	225709558	+	Splice_Site	SNP	T	T	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:225709558T>A	ENST00000409592.3	-	22	2577		c.e22-2		DOCK10_ENST00000258390.7_Splice_Site			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10								GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CCCACCATGCTGCAAAATAAA	0.353000													5	8					0	0	0.014758	0	0
MMP9	4318	broad.mit.edu	37	20	44639914	44639914	+	Missense_Mutation	SNP	A	A	G	rs144229833		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:44639914A>G	ENST00000372330.3	+	5	801	c.782A>G	c.(781-783)aAc>aGc	p.N261S		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	261	Fibronectin type-II 1.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	ACCACGGCCAACTACGACACC	0.677000													7	99					0	0	0.038147	0	0
IWS1	55677	broad.mit.edu	37	2	128255738	128255738	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:128255738C>T	ENST00000295321.4	-	6	1802	c.1543G>A	c.(1543-1545)Gat>Aat	p.D515N	AC010976.2_ENST00000599001.1_RNA|IWS1_ENST00000455721.2_Intron	NM_017969.2	NP_060439.2	Q96ST2	IWS1_HUMAN	IWS1 homolog (S. cerevisiae)	515					transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(2)|kidney(6)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		TTTATGTTATCATCAGAATCT	0.303000													4	27					0	0	0.009096	0	0
CPS1	1373	broad.mit.edu	37	2	211447412	211447412	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:211447412G>C	ENST00000233072.5	+	6	796	c.600G>C	c.(598-600)ttG>ttC	p.L200F	CPS1_ENST00000430249.2_Missense_Mutation_p.L206F	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	200	Anthranilate phosphoribosyltransferase homolog.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AACAGAATTTGATTGCTGAGG	0.323000													10	24					0	0	0.080935	0	0
COL15A1	1306	broad.mit.edu	37	9	101806867	101806867	+	Silent	SNP	G	G	A	rs138283764	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:101806867G>A	ENST00000375001.3	+	25	3015	c.2592G>A	c.(2590-2592)ccG>ccA	p.P864P		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	864	Triple-helical region 4 (COL4).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				AGGGAGAGCCGGGTGCCATCC	0.517000													7	19					0	0	0.038147	0	0
CCDC33	80125	broad.mit.edu	37	15	74574148	74574148	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:74574148G>T	ENST00000321288.5	+	12	1662	c.1662G>T	c.(1660-1662)gaG>gaT	p.E554D	CCDC33_ENST00000398814.3_Missense_Mutation_p.E351D			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	554							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						TCAATGATGAGGCCCCCACAG	0.597000													21	67					1.5548e-18	2.17529e-18	0.108266	1	0
INHBA	3624	broad.mit.edu	37	7	41729684	41729684	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:41729684T>C	ENST00000242208.4	-	3	1091	c.845A>G	c.(844-846)gAt>gGt	p.D282G	INHBA_ENST00000442711.1_Missense_Mutation_p.D282G|AC005027.3_ENST00000416150.1_RNA|INHBA_ENST00000464515.1_5'UTR	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	282					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						cttttcctcatctgctcctgc	0.597000										TSP Lung(11;0.080)			14	30					0	0	0.020292	0	0
MYO16	23026	broad.mit.edu	37	13	109507808	109507808	+	Silent	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr13:109507808T>C	ENST00000356711.2	+	11	1326	c.1200T>C	c.(1198-1200)ccT>ccC	p.P400P	MYO16_ENST00000251041.5_Silent_p.P400P|MYO16_ENST00000357550.2_Silent_p.P400P	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	400					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TAATGCCTCCTGCCCCAAACG	0.458000													10	42					0	0	0.069234	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14851708	14851708	+	Silent	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr18:14851708A>T	ENST00000358984.4	+	36	3588	c.3408A>T	c.(3406-3408)acA>acT	p.T1136T		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1221										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						AACAGAAAACAGTAACAAAAA	0.353000													6	20					0	0	0.021553	0	0
SCAND3	114821	broad.mit.edu	37	6	28543125	28543125	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:28543125T>C	ENST00000452236.2	-	3	1974	c.1357A>G	c.(1357-1359)Att>Gtt	p.I453V		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	453	Integrase catalytic.				DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						TCTGGCCAAATATTACTGAGT	0.418000													4	15					0	0	0.014758	0	0
CXorf64	100130613	broad.mit.edu	37	X	125955417	125955417	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:125955417G>C	ENST00000371125.3	+	2	876	c.796G>C	c.(796-798)Gct>Cct	p.A266P		NM_001122716.1	NP_001116188.1	B1ATL7	CX064_HUMAN	chromosome X open reading frame 64	266	Pro-rich.																TCTTCCTTTTGCTCCTCCTCC	0.488000													9	14					0	0	0.069234	0	0
FRMD1	79981	broad.mit.edu	37	6	168479609	168479609	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:168479609C>T	ENST00000283309.6	-	1	230	c.166G>A	c.(166-168)Gtc>Atc	p.V56I		NM_024919.3	NP_079195.3	Q8N878	FRMD1_HUMAN	FERM domain containing 1	56	FERM.					cytoskeleton	binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	19		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		AGCACGAGGACATCCCTGTGT	0.667000													8	31					0	0	0.058154	0	0
IFNA16	3449	broad.mit.edu	37	9	21217301	21217301	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:21217301C>A	ENST00000380216.1	-	1	9	c.4G>T	c.(4-6)Gcc>Tcc	p.A2S		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	2					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		AAGGACAGGGCCATTGGGATG	0.473000													20	44					1.28384e-07	1.58531e-07	0.062417	1	0
DMKN	93099	broad.mit.edu	37	19	36004272	36004272	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:36004272C>T	ENST00000339686.3	-	1	282	c.106G>A	c.(106-108)Ggg>Agg	p.G36R	DMKN_ENST00000418261.1_Missense_Mutation_p.G36R|DMKN_ENST00000419602.1_Missense_Mutation_p.G36R|DMKN_ENST00000429837.1_Missense_Mutation_p.G36R|DMKN_ENST00000424570.2_Missense_Mutation_p.G36R|DMKN_ENST00000451297.2_Missense_Mutation_p.G36R|DMKN_ENST00000447113.2_Missense_Mutation_p.G36R|DMKN_ENST00000440396.1_Missense_Mutation_p.G36R	NM_033317.4	NP_201574.3	Q6E0U4	DMKN_HUMAN	dermokine	36	Gly-rich.					extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			AGGGCCTCCCCAATATTTGTC	0.657000													19	27					0	0	0.076483	0	0
PSG5	5673	broad.mit.edu	37	19	43680281	43680281	+	Silent	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:43680281G>A	ENST00000404580.1	-	3	538	c.450C>T	c.(448-450)taC>taT	p.Y150Y	PSG5_ENST00000599812.1_Silent_p.Y243Y|PSG5_ENST00000342951.6_Silent_p.Y150Y|PSG5_ENST00000407356.1_Silent_p.Y150Y|PSG5_ENST00000366175.3_Silent_p.Y150Y|PSG5_ENST00000407568.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	150	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				TGATGGTGATGTAGGGCTTGG	0.468000													56	169					0	0	0.048971	0	0
OR7A5	26659	broad.mit.edu	37	19	14938184	14938184	+	Silent	SNP	A	A	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:14938184A>G	ENST00000322301.3	-	2	957	c.870T>C	c.(868-870)taT>taC	p.Y290Y	OR7A5_ENST00000601611.1_Intron|OR7A5_ENST00000594432.1_Silent_p.Y290Y			Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A, member 5	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Y290Y(2)		breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26						TCCTCAGACTATAGATAAAGG	0.478000													3	62					0	0	0.004672	0	0
CD86	942	broad.mit.edu	37	3	121828232	121828232	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:121828232G>A	ENST00000330540.2	+	5	940	c.824G>A	c.(823-825)cGg>cAg	p.R275Q	CD86_ENST00000393627.2_Missense_Mutation_p.R269Q|CD86_ENST00000469710.1_Missense_Mutation_p.R193Q|CD86_ENST00000493101.1_Missense_Mutation_p.R163Q|CD86_ENST00000264468.5_Missense_Mutation_p.R62Q	NM_175862.4	NP_787058.4	P42081	CD86_HUMAN	CD86 molecule	275					interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			breast(2)|endometrium(1)|kidney(1)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	23				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	AAGAAGAAGCGGCCTCGCAAC	0.473000													16	81					0	0	0.038395	0	0
C1orf106	55765	broad.mit.edu	37	1	200880665	200880665	+	Silent	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:200880665G>A	ENST00000367342.4	+	9	1499	c.1299G>A	c.(1297-1299)gtG>gtA	p.V433V	C1orf106_ENST00000413687.2_Silent_p.V348V	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	433										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						CGGTGACAGTGCCAGATTCCT	0.667000													26	78					0	0	0.064281	0	0
PCDH15	65217	broad.mit.edu	37	10	55581630	55581630	+	Silent	SNP	A	A	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:55581630A>C	ENST00000361849.3	-	34	6256	c.5862T>G	c.(5860-5862)tcT>tcG	p.S1954S	PCDH15_ENST00000437009.1_Silent_p.S1883S|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000373957.3_Silent_p.S806S|PCDH15_ENST00000320301.6_Silent_p.S1952S|PCDH15_ENST00000395433.1_Silent_p.S1929S|PCDH15_ENST00000395432.2_Silent_p.S1912S|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395430.1_Silent_p.S1949S|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000463095.1_5'UTR	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1952					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ACAGTGAAGTAGATTGACTGT	0.363000										HNSCC(58;0.16)			31	20					0	0	0.069456	0	0
ISL1	3670	broad.mit.edu	37	5	50683572	50683572	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:50683572T>A	ENST00000230658.7	+	3	1052	c.467T>A	c.(466-468)cTg>cAg	p.L156Q	ISL1_ENST00000505475.2_3'UTR|ISL1_ENST00000511384.1_Missense_Mutation_p.L156Q	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	156					generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				GCGCGGCCACTGCAAATGGCA	0.652000													8	9					0	0	0.093190	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455751	5455751	+	Silent	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:5455751C>G	ENST00000222033.4	+	1	326	c.249C>G	c.(247-249)gtC>gtG	p.V83V		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	83						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		TCGTGGCAGTCAAAGCCTTGC	0.667000													5	28					0	0	0.058154	0	0
C1orf173	127254	broad.mit.edu	37	1	75078310	75078310	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:75078310T>C	ENST00000326665.5	-	9	1402	c.1184A>G	c.(1183-1185)tAc>tGc	p.Y395C	C1orf173_ENST00000420661.2_Missense_Mutation_p.Y198C|RP4-612J11.1_ENST00000416017.1_RNA	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	395										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCCATACTTGTAGCAAGGAGA	0.398000													11	30					0	0	0.093190	0	0
BARHL1	56751	broad.mit.edu	37	9	135464768	135464768	+	Silent	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:135464768C>A	ENST00000263610.2	+	3	1456	c.843C>A	c.(841-843)cgC>cgA	p.R281R	BARHL1_ENST00000542090.1_Silent_p.R281R	NM_020064.3	NP_064448.1	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	281						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(2)|lung(2)|skin(3)	8				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		ACCTGTACCGCGGCCCCAGCG	0.697000													10	34					2.17888e-05	2.50776e-05	0.058154	1	0
SERPINA11	256394	broad.mit.edu	37	14	94914752	94914752	+	Silent	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr14:94914752C>A	ENST00000334708.3	-	2	424	c.360G>T	c.(358-360)cgG>cgT	p.R120R	RP11-349I1.2_ENST00000536735.1_RNA	NM_001080451.1	NP_001073920.1	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	120					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(14)|skin(1)|upper_aerodigestive_tract(1)	24				COAD - Colon adenocarcinoma(157;0.211)		GGAGGAGGCTCCGGAAGCCCT	0.567000													63	114					3.4779e-39	5.12444e-39	0.048971	1	0
CHRD	8646	broad.mit.edu	37	3	184105183	184105183	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:184105183G>A	ENST00000204604.1	+	19	2615	c.2369G>A	c.(2368-2370)cGg>cAg	p.R790Q	CHRD_ENST00000348986.3_Missense_Mutation_p.R750Q|CHRD_ENST00000545352.1_Missense_Mutation_p.R332Q|CHRD_ENST00000450923.1_Missense_Mutation_p.R790Q|EIF2B5_ENST00000444495.1_Intron	NM_003741.2	NP_003732.2	Q9H2X0	CHRD_HUMAN	chordin	790	VWFC 3.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(23)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GATGGTGACCGGAGCTGGCGG	0.597000													4	27					0	0	0.021553	0	0
ALPK2	115701	broad.mit.edu	37	18	56204135	56204135	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr18:56204135A>T	ENST00000361673.3	-	5	3497	c.3284T>A	c.(3283-3285)tTc>tAc	p.F1095Y	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1095							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						ATTACTGCAGAAACCCTCTCC	0.498000													20	91					0	0	0.062417	0	0
SPAM1	6677	broad.mit.edu	37	7	123599760	123599760	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:123599760C>A	ENST00000340011.5	+	5	1624	c.1267C>A	c.(1267-1269)Ctt>Att	p.L423I	SPAM1_ENST00000223028.7_Missense_Mutation_p.L423I|SPAM1_ENST00000460182.1_Missense_Mutation_p.L423I|SPAM1_ENST00000439500.1_Missense_Mutation_p.L423I|SPAM1_ENST00000402183.2_Missense_Mutation_p.L423I	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	423					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	AAAACCGACACTTGAAGACCT	0.383000													14	66					3.35478e-16	4.58837e-16	0.024245	1	0
IARS	3376	broad.mit.edu	37	9	95015664	95015664	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:95015664T>G	ENST00000375643.3	-	21	2475	c.2209A>C	c.(2209-2211)Atg>Ctg	p.M737L	IARS_ENST00000443024.2_Missense_Mutation_p.M737L|IARS_ENST00000375629.3_5'UTR|IARS_ENST00000447699.2_Missense_Mutation_p.M627L	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	737					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	CTGCGGTTCATTCTAACATAC	0.398000													3	46					0	0	0.004672	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459863	66459863	+	RNA	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:66459863G>A	ENST00000424345.1	+	0	123																											tttcctggatggtgttgatgc	0.363000													4	33					0	0	0.009096	0	0
RBP2	5948	broad.mit.edu	37	3	139180964	139180964	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:139180964C>T	ENST00000232217.2	-	2	298	c.242G>A	c.(241-243)cGg>cAg	p.R81Q	RP11-319G6.1_ENST00000515247.1_RNA	NM_004164.2	NP_004155.2	P50120	RET2_HUMAN	retinol binding protein 2, cellular	81					epidermis development|retinoid metabolic process|steroid metabolic process|vitamin A metabolic process	cytosol	retinal binding|retinol binding|transporter activity			breast(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12					Vitamin A(DB00162)	CTTAACATGCCGGTTATCCAG	0.418000													10	73					0	0	0.058154	0	0
EP400	57634	broad.mit.edu	37	12	132498035	132498035	+	Splice_Site	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:132498035C>G	ENST00000333577.4	+	19	3829	c.3719_splice	c.e19-1	p.S1240_splice	EP400_ENST00000332482.4_Splice_Site_p.S1167_splice|EP400_ENST00000389562.2_Splice_Site_p.S1203_splice|EP400_ENST00000389561.2_Splice_Site_p.S1204_splice|EP400_ENST00000330386.6_Splice_Site_p.S1204_splice			Q96L91	EP400_HUMAN	E1A binding protein p400	1240	Helicase ATP-binding.|Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CTGTTTGCAGCCAACAACGTC	0.547000													19	43					0	0	0.076483	0	0
CHD3	1107	broad.mit.edu	37	17	7801419	7801419	+	Splice_Site	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:7801419C>T	ENST00000380358.4	+	12	2228	c.2228_splice	c.e12+1	p.R743_splice	CHD3_ENST00000358181.4_Splice_Site_p.R684_splice|CHD3_ENST00000330494.7_Splice_Site_p.R684_splice	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	684					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CTGGAGACACCGGTGAGGGAA	0.458000													50	87					0	0	0.048971	0	0
MPP1	4354	broad.mit.edu	37	X	154007590	154007590	+	Silent	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:154007590G>T	ENST00000413259.3	-	13	1565	c.1173C>A	c.(1171-1173)gcC>gcA	p.A391A	MPP1_ENST00000393531.1_Silent_p.A401A|MPP1_ENST00000369534.3_Silent_p.A421A	NM_001166462.1	NP_001159934.1	Q00013	EM55_HUMAN	membrane protein, palmitoylated 1, 55kDa	421	Guanylate kinase-like.|Interaction with MPP5.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(9)|ovary(2)|prostate(1)	21	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GGCTGCGGATGGCCTCAGAGT	0.527000													8	79					3.09899e-07	3.75076e-07	0.047766	1	0
FCRL1	115350	broad.mit.edu	37	1	157771907	157771907	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:157771907G>T	ENST00000358292.3	-	5	735	c.684C>A	c.(682-684)caC>caA	p.H228Q	FCRL1_ENST00000368176.3_Missense_Mutation_p.H228Q|FCRL1_ENST00000491942.1_Missense_Mutation_p.H228Q|FCRL1_ENST00000489998.1_5'UTR	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	228	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GGGCCTCACAGTGAAGCTCCA	0.612000													10	59					0.00136819	0.0015065	0.093190	1	0
GDF3	9573	broad.mit.edu	37	12	7843254	7843254	+	Silent	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:7843254C>T	ENST00000329913.3	-	2	362	c.315G>A	c.(313-315)ctG>ctA	p.L105L		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	105					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						GGAGCTTCTGCAGGCAGGAGG	0.443000													7	48					0	0	0.058154	0	0
OPN1LW	5956	broad.mit.edu	37	X	153421993	153421993	+	Silent	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:153421993C>A	ENST00000369951.4	+	5	1029	c.969C>A	c.(967-969)gtC>gtA	p.V323V		NM_020061.4	NP_064445.1	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	323					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	15	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTATCTATGTCTTTATGAACC	0.532000													33	96					1.76056e-25	2.557e-25	0.042209	1	0
KIAA1614	57710	broad.mit.edu	37	1	180886045	180886045	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:180886045C>T	ENST00000367588.4	+	2	861	c.806C>T	c.(805-807)aCg>aTg	p.T269M		NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	269										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						GTCCCCAGGACGGCCCTGCTG	0.617000													21	78					0	0	0.062417	0	0
MAGEA3	4102	broad.mit.edu	37	X	151935513	151935513	+	Silent	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:151935513C>T	ENST00000393902.3	-	3	1221	c.654G>A	c.(652-654)gaG>gaA	p.E218E	MAGEA3_ENST00000370278.3_Silent_p.E218E			P43357	MAGA3_HUMAN	melanoma antigen family A, 3	218	MAGE.									endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)	15	Acute lymphoblastic leukemia(192;6.56e-05)					AGATTTTCTCCTCAGGGGCAC	0.552000													34	100					0	0	0.098360	0	0
RASGRF2	5924	broad.mit.edu	37	5	80376547	80376547	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:80376547A>C	ENST00000265080.4	+	7	1167	c.1100A>C	c.(1099-1101)gAa>gCa	p.E367A	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	367	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		AAACAGTATGAAGCCAATCCA	0.418000													5	41					0	0	0.021553	0	0
REG1P	5969	broad.mit.edu	37	2	79364148	79364148	+	RNA	SNP	A	A	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:79364148A>G	ENST00000444841.1	-	0	285																											AGGACAGCACAGAAATGTCCC	0.463000													4	23					0	0	0.009096	0	0
NEUROD4	58158	broad.mit.edu	37	12	55420509	55420509	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:55420509G>A	ENST00000242994.3	+	2	664	c.286G>A	c.(286-288)Gaa>Aaa	p.E96K		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	96					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						TAATGCCAGAGAACGGACCCG	0.498000													35	115					0	0	0.080422	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274291	39274291	+	Missense_Mutation	SNP	T	T	C	rs149439944	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:39274291T>C	ENST00000391413.2	-	1	315	c.277A>G	c.(277-279)Atg>Gtg	p.M93V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	93	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.M93V(4)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCAGCACATAGACTGGCAG	0.662000													3	26					0	0	0.009096	0	0
COL5A2	1290	broad.mit.edu	37	2	189933534	189933534	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:189933534G>T	ENST00000374866.3	-	19	1509	c.1235C>A	c.(1234-1236)cCa>cAa	p.P412Q		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	412					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AGAGCCAACTGGACCTGGGGG	0.502000													4	12					0.00909568	0.00969994	0.009096	1	0
CYR61	3491	broad.mit.edu	37	1	86047826	86047826	+	Missense_Mutation	SNP	G	G	A	rs146738107		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:86047826G>A	ENST00000451137.2	+	3	717	c.493G>A	c.(493-495)Gag>Aag	p.E165K		NM_001554.4	NP_001545.2	O00622	CYR61_HUMAN	cysteine-rich, angiogenic inducer, 61	165				E -> Q (in Ref. 2; CAA72167).	cell proliferation|chemotaxis|positive regulation of BMP signaling pathway|positive regulation of cell migration|positive regulation of osteoblast differentiation|positive regulation of osteoblast proliferation|positive regulation of protein kinase activity|positive regulation of protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell growth|regulation of ERK1 and ERK2 cascade|wound healing, spreading of cells	extracellular region	heparin binding|insulin-like growth factor binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|prostate(1)	5				all cancers(265;0.0216)|Epithelial(280;0.0441)		GGTCTGTGACGAGGATAGTAT	0.567000											OREG0013583	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	64					0	0	0.058154	0	0
PTER	9317	broad.mit.edu	37	10	16526695	16526695	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:16526695C>A	ENST00000378000.1	+	3	558	c.312C>A	c.(310-312)agC>agA	p.S104R	PTER_ENST00000423462.2_Missense_Mutation_p.S104R|PTER_ENST00000298942.3_Missense_Mutation_p.S104R|PTER_ENST00000535784.2_Missense_Mutation_p.S104R|PTER_ENST00000485788.1_3'UTR	NM_001001484.2|NM_001261838.1|NM_030664.4	NP_001001484.1|NP_001248767.1|NP_109589.2	Q96BW5	PTER_HUMAN	phosphotriesterase related	104					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)	15						CTGGGATTAGCCGAGACACAC	0.458000													11	43					4.36969e-10	5.6713e-10	0.105934	1	0
HSD17B7	51478	broad.mit.edu	37	1	162773268	162773268	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:162773268G>T	ENST00000254521.3	+	6	745	c.690G>T	c.(688-690)ttG>ttT	p.L230F	HSD17B7_ENST00000485405.1_3'UTR|HSD17B7_ENST00000367917.3_Intron	NM_016371.2	NP_057455.1	P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	230					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity			endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_hematologic(112;0.115)				NADH(DB00157)	TGACCAATTTGACATATGGAA	0.398000													15	59					7.33628e-21	1.04559e-20	0.069288	1	0
ZNF483	158399	broad.mit.edu	37	9	114304933	114304933	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:114304933A>G	ENST00000309235.5	+	6	1876	c.1718A>G	c.(1717-1719)cAt>cGt	p.H573R	ZNF483_ENST00000358151.4_Intron	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	573					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						CAGAGAATTCATACTGGAGAG	0.413000													18	77					0	0	0.055883	0	0
TMEM175	84286	broad.mit.edu	37	4	949544	949544	+	Splice_Site	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:949544C>A	ENST00000264771.4	+	10	893	c.706_splice	c.e10-1	p.G236_splice	TMEM175_ENST00000515740.1_Splice_Site_p.G120_splice|TMEM175_ENST00000508204.1_Splice_Site_p.G154_splice	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	236						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			TGTCCCCAGGCCACAGGGAGC	0.642000													4	7					0.00116845	0.00129122	0.021553	1	0
CPNE1	8904	broad.mit.edu	37	20	34215225	34215225	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:34215225C>T	ENST00000317619.3	-	16	1607	c.1213G>A	c.(1213-1215)Gct>Act	p.A405T	CPNE1_ENST00000352393.4_Missense_Mutation_p.A405T|CPNE1_ENST00000317677.5_Missense_Mutation_p.A410T|CPNE1_ENST00000397443.1_Missense_Mutation_p.A405T|CPNE1_ENST00000397442.1_Missense_Mutation_p.A405T|CPNE1_ENST00000397445.1_Missense_Mutation_p.A405T|CPNE1_ENST00000397446.1_Missense_Mutation_p.A405T			Q99829	CPNE1_HUMAN	copine I	405	VWFA.				lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			breast(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			TGATGTGCAGCCTGGGCTGCA	0.562000													4	100					0	0	0.014758	0	0
RXRG	6258	broad.mit.edu	37	1	165398014	165398014	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:165398014G>T	ENST00000359842.5	-	2	541	c.239C>A	c.(238-240)cCc>cAc	p.P80H		NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	80	Modulating (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	TGCTCCTGAGGGTGGGCCCAT	0.592000													18	58					1.67942e-08	2.10791e-08	0.038395	1	0
NAP1L2	4674	broad.mit.edu	37	X	72433353	72433353	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:72433353C>A	ENST00000373517.3	-	1	1331	c.976G>T	c.(976-978)Gag>Tag	p.E326*	NAP1L2_ENST00000536638.1_Nonsense_Mutation_p.E184*	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	326					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					GTGGAATACTCAATCGCAGTT	0.403000													48	75					4.37618e-36	6.417e-36	0.048971	1	0
FIZ1	84922	broad.mit.edu	37	19	56109113	56109113	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:56109113C>G	ENST00000221665.3	-	2	208	c.119G>C	c.(118-120)cGc>cCc	p.R40P	FIZ1_ENST00000592585.1_Missense_Mutation_p.R40P	NM_032836.2	NP_116225.2	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	40					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)	11			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		GGCAAAGTGGCGCCGCAGGTC	0.667000													19	34					0	0	0.069288	0	0
HDGFL1	154150	broad.mit.edu	37	6	22569903	22569903	+	Silent	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:22569903C>T	ENST00000510882.2	+	1	109	c.99C>T	c.(97-99)acC>acT	p.T33T	HDGFL1_ENST00000230012.3_Silent_p.T33T			Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	33	PWWP.									kidney(1)|large_intestine(3)|lung(7)	11	Ovarian(93;0.163)					AGCACATGACCCAGCCCAACC	0.582000													8	18					0	0	0.069234	0	0
ZNF229	7772	broad.mit.edu	37	19	44932522	44932522	+	Missense_Mutation	SNP	G	G	A	rs61742344		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:44932522G>A	ENST00000291187.4	-	6	2738	c.2416C>T	c.(2416-2418)Cgg>Tgg	p.R806W	ZNF229_ENST00000591289.1_Intron|CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000588931.1_Missense_Mutation_p.R812W	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	812					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				TGGTGGTTCCGCAGACCTGAG	0.483000													5	50					0	0	0.021553	0	0
SLC5A9	200010	broad.mit.edu	37	1	48696360	48696360	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:48696360C>T	ENST00000236495.5	+	6	718	c.668C>T	c.(667-669)gCc>gTc	p.A223V	SLC5A9_ENST00000533824.1_Missense_Mutation_p.A219V|SLC5A9_ENST00000438567.2_Missense_Mutation_p.A198V|SLC5A9_ENST00000420136.2_3'UTR	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	198						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						GTGGTGACTGCCGTCTACACC	0.552000													17	47					0	0	0.055883	0	0
IARS	3376	broad.mit.edu	37	9	95015646	95015646	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:95015646T>G	ENST00000375643.3	-	21	2493	c.2227A>C	c.(2227-2229)Aag>Cag	p.K743Q	IARS_ENST00000443024.2_Missense_Mutation_p.K743Q|IARS_ENST00000375629.3_5'UTR|IARS_ENST00000447699.2_Missense_Mutation_p.K633Q	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	743					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	GCACTTACCTTTAATCTTCTG	0.383000													3	42					0	0	0.004672	0	0
PLCL2	23228	broad.mit.edu	37	3	17051510	17051510	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:17051510G>C	ENST00000418129.2	+	2	759	c.294G>C	c.(292-294)gaG>gaC	p.E98D	PLCL2_ENST00000460467.1_3'UTR|PLCL2_ENST00000396755.2_Missense_Mutation_p.E98D|PLCL2_ENST00000432376.1_Missense_Mutation_p.E98D	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	224					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.E98D(1)		breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						TATATGGAGAGAATTATGAGT	0.418000													5	68					0	0	0.014758	0	0
TTN	7273	broad.mit.edu	37	2	179409131	179409131	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:179409131A>G	ENST00000589042.1	-	345	96049	c.95825T>C	c.(95824-95826)gTa>gCa	p.V31942A	TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V29374A|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.V22877A|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V30301A|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V23002A|TTN_ENST00000342175.6_Missense_Mutation_p.V23069A|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30301	Ig-like 141.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACATATCCTACAATGTCAGT	0.463000													23	61					0	0	0.083992	0	0
PRKAR2A	5576	broad.mit.edu	37	3	48810501	48810501	+	Missense_Mutation	SNP	G	G	A	rs147886817		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:48810501G>A	ENST00000265563.8	-	6	832	c.583C>T	c.(583-585)Cgc>Tgc	p.R195C	PRKAR2A_ENST00000454963.1_Missense_Mutation_p.R195C|PRKAR2A_ENST00000296446.8_Missense_Mutation_p.R195C	NM_004157.2	NP_004148.1	P13861	KAP2_HUMAN	protein kinase, cAMP-dependent, regulatory, type II, alpha	195					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|membrane fraction	cAMP binding|cAMP-dependent protein kinase regulator activity		SLC26A6/PRKAR2A(2)	breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.000176)|Kidney(197;0.00246)|KIRC - Kidney renal clear cell carcinoma(197;0.00261)		CCAACAGAGCGGGTTTGATTA	0.383000													8	53					0	0	0.047766	0	0
FOXL1	2300	broad.mit.edu	37	16	86612429	86612429	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr16:86612429C>T	ENST00000320241.3	+	1	315	c.100C>T	c.(100-102)Ccc>Tcc	p.P34S		NM_005250.2	NP_005241.1	Q12952	FOXL1_HUMAN	forkhead box L1	34					brain development|camera-type eye development|cartilage development|embryo development|forelimb morphogenesis|heart development|organ morphogenesis|pattern specification process|proteoglycan biosynthetic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt receptor signaling pathway|visceral mesoderm-endoderm interaction involved in midgut development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(2)|prostate(3)|skin(1)|urinary_tract(1)	15						GGCCTTCGCCCCCGCGGCTGC	0.697000													7	13					0	0	0.069234	0	0
OR5L2	26338	broad.mit.edu	37	11	55595206	55595206	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:55595206C>A	ENST00000378397.1	+	1	512	c.512C>A	c.(511-513)tCt>tAt	p.S171Y		NM_001004739.1	NP_001004739.1	Q8NGL0	OR5L2_HUMAN	olfactory receptor, family 5, subfamily L, member 2	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(1)|lung(42)|ovary(1)|prostate(3)|skin(1)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	59		all_epithelial(135;0.208)				TTCTATAGATCTAATGTGATT	0.488000										HNSCC(27;0.073)			54	154					1.72845e-40	2.55911e-40	0.048971	1	0
CCDC142	84865	broad.mit.edu	37	2	74708398	74708398	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:74708398C>G	ENST00000393965.3	-	3	1606	c.1210G>C	c.(1210-1212)Gat>Cat	p.D404H	CCDC142_ENST00000290418.4_Missense_Mutation_p.D404H|CCDC142_ENST00000471713.1_5'UTR	NM_032779.3	NP_116168.3	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	404										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	16						CGAAGGGCATCCAAGAGAGGA	0.572000													12	29					0	0	0.093190	0	0
RSU1P2	100133308	broad.mit.edu	37	10	45602403	45602403	+	RNA	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:45602403C>A	ENST00000423875.1	-	0	1033																											CCCTACAAGGCTGCAGCAGTG	0.388000													6	6					2.0095e-06	2.39413e-06	0.029380	1	0
OR11L1	391189	broad.mit.edu	37	1	248004585	248004585	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:248004585G>T	ENST00000355784.2	-	1	669	c.614C>A	c.(613-615)gCc>gAc	p.A205D		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCACAGCACGGCAATTGACAG	0.473000													44	123					2.35958e-20	3.34732e-20	0.111260	1	0
UNC5D	137970	broad.mit.edu	37	8	35616848	35616848	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:35616848C>T	ENST00000287272.2	+	13	1987	c.1967C>T	c.(1966-1968)tCa>tTa	p.S656L	UNC5D_ENST00000449677.1_Missense_Mutation_p.S301L|UNC5D_ENST00000453357.2_Missense_Mutation_p.S720L|UNC5D_ENST00000420357.1_Missense_Mutation_p.S658L|UNC5D_ENST00000404895.2_Missense_Mutation_p.S725L|UNC5D_ENST00000416672.1_Missense_Mutation_p.S730L			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	725					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GAAGTGGTTTCAGATGAAAGG	0.378000													12	47					0	0	0.080935	0	0
OR5J2	282775	broad.mit.edu	37	11	55944493	55944493	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:55944493G>C	ENST00000312298.1	+	1	400	c.400G>C	c.(400-402)Gta>Cta	p.V134L		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					GCTTTACACTGTAGCCATGTC	0.458000													8	42					0	0	0.058154	0	0
EBF2	64641	broad.mit.edu	37	8	25899680	25899680	+	Silent	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:25899680G>T	ENST00000520164.1	-	2	756	c.219C>A	c.(217-219)ctC>ctA	p.L73L		NM_022659.3	NP_073150.2	Q9HAK2	COE2_HUMAN	early B-cell factor 2	73					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GCCTGTCATAGAGCGCCAGGA	0.592000													8	54					5.50884e-06	6.48724e-06	0.093190	1	0
FBXO25	26260	broad.mit.edu	37	8	413123	413123	+	Silent	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:413123T>C	ENST00000352684.2	+	8	1176	c.759T>C	c.(757-759)tgT>tgC	p.C253C	FBXO25_ENST00000519376.1_3'UTR|FBXO25_ENST00000350302.3_Silent_p.C320C|FBXO25_ENST00000382824.1_Silent_p.C253C|FBXO25_ENST00000276326.5_Silent_p.C320C	NM_012173.3	NP_036305.2	Q8TCJ0	FBX25_HUMAN	F-box protein 25	320	F-box.					nucleus|SCF ubiquitin ligase complex	actin binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10		Ovarian(12;0.00965)|Colorectal(14;0.0815)|Myeloproliferative disorder(644;0.116)|all_neural(12;0.122)		Epithelial(5;3.14e-14)|OV - Ovarian serous cystadenocarcinoma(5;1.56e-07)|BRCA - Breast invasive adenocarcinoma(11;1.88e-06)		TGCATTTCTGTCGGCACTGCA	0.378000													10	125					0	0	0.093190	0	0
OR5A2	219981	broad.mit.edu	37	11	59189969	59189969	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:59189969C>G	ENST00000302040.4	-	1	480	c.458G>C	c.(457-459)gGa>gCa	p.G153A		NM_001001954.1	NP_001001954.1	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A, member 2	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	21						ACTAAGGAATCCACCCACATA	0.458000													8	59					0	0	0.047766	0	0
MIR891B	100126304	broad.mit.edu	37	X	145082576	145082576	+	RNA	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:145082576T>C	ENST00000401245.1	-	0	73					NR_030590.1																						ttatctcttttgaccctaaca	0.388000													8	12					0	0	0.038147	0	0
DEFB136	613210	broad.mit.edu	37	8	11832060	11832060	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:11832060G>T	ENST00000382209.2	-	1	48	c.49C>A	c.(49-51)Cct>Act	p.P17T		NM_001033018.2	NP_001028190.2	Q30KP8	DB136_HUMAN	defensin, beta 136	17					defense response to bacterium	extracellular region				endometrium(2)|large_intestine(1)|lung(4)	7			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.163)		TTACCTGAAGGCAGTAAGATC	0.483000													33	183					3.33393e-15	4.49934e-15	0.074837	1	0
NXPE4	54827	broad.mit.edu	37	11	114442052	114442052	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:114442052A>T	ENST00000375478.3	-	6	1423	c.1243T>A	c.(1243-1245)Tac>Aac	p.Y415N	NXPE4_ENST00000424261.2_Missense_Mutation_p.Y131N	NM_001077639.1	NP_001071107.1			neurexophilin and PC-esterase domain family, member 4																		CGGGTGAGGTACTCCATCTCT	0.423000													21	94					0	0	0.083992	0	0
GRIK3	2899	broad.mit.edu	37	1	37319244	37319244	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:37319244A>T	ENST00000373091.3	-	8	1200	c.1184T>A	c.(1183-1185)aTc>aAc	p.I395N	GRIK3_ENST00000373093.4_Missense_Mutation_p.I395N|GRIK3_ENST00000462621.1_5'UTR	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	395					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TTTCAGGCTGATGATGTCCAG	0.547000													10	3					0	0	0.058154	0	0
DSG1	1828	broad.mit.edu	37	18	28908227	28908227	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr18:28908227G>A	ENST00000257192.4	+	4	504	c.292G>A	c.(292-294)Ggg>Agg	p.G98R		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	98	Cadherin 1.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GCCACCATATGGGATCTTTGT	0.388000													4	19					0	0	0.014758	0	0
SH3BP5L	80851	broad.mit.edu	37	1	249106452	249106452	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:249106452C>A	ENST00000366472.5	-	7	2058	c.829G>T	c.(829-831)Ggg>Tgg	p.G277W	SH3BP5L_ENST00000475978.1_5'UTR|SH3BP5L_ENST00000411742.2_Missense_Mutation_p.G245W	NM_030645.1	NP_085148.1	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	277								p.G277R(1)		endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GGCAGACCCCCGCGGCGCCGT	0.692000													7	21					1.06961e-07	1.33156e-07	0.038147	1	0
EPN1	29924	broad.mit.edu	37	19	56204360	56204360	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:56204360T>G	ENST00000411543.2	+	9	2026	c.1479T>G	c.(1477-1479)ttT>ttG	p.F493L	EPN1_ENST00000085079.7_Missense_Mutation_p.F381L|EPN1_ENST00000270460.6_Missense_Mutation_p.F407L	NM_001130071.1	NP_001123543.1	Q9Y6I3	EPN1_HUMAN	epsin 1	407	Ala/Gly/Pro-rich.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	17		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		TCTCTGACTTTGACCGACTCC	0.701000													10	51					0	0	0.093190	0	0
CLU	1191	broad.mit.edu	37	8	27472255	27472255	+	Missense_Mutation	SNP	T	T	C	rs2077086		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:27472255T>C	ENST00000560366.1	-	1	72	c.44A>G	c.(43-45)cAg>cGg	p.Q15R	CLU_ENST00000316403.10_5'UTR	NM_001831.3	NP_001822.3	P10909	CLUS_HUMAN	clusterin	0					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		TATAGCGCTCTGCTCGCGCAC	0.657000											OREG0018671	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	23					0	0	0.009096	0	0
CSMD1	64478	broad.mit.edu	37	8	2820774	2820774	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:2820774C>T	ENST00000602557.1	-	61	9982	c.9427G>A	c.(9427-9429)Gtg>Atg	p.V3143M	CSMD1_ENST00000400186.3_Missense_Mutation_p.V2966M|CSMD1_ENST00000520002.1_Missense_Mutation_p.V3143M|CSMD1_ENST00000542608.1_Missense_Mutation_p.V2965M|CSMD1_ENST00000537824.1_Missense_Mutation_p.V3142M|CSMD1_ENST00000602723.1_Missense_Mutation_p.V2966M			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3143	Sushi 25.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCTTTCCACACCCCGCGACCT	0.567000													17	56					0	0	0.099896	0	0
C1orf106	55765	broad.mit.edu	37	1	200880666	200880666	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:200880666C>A	ENST00000367342.4	+	9	1500	c.1300C>A	c.(1300-1302)Cca>Aca	p.P434T	C1orf106_ENST00000413687.2_Missense_Mutation_p.P349T	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	434										endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						GGTGACAGTGCCAGATTCCTG	0.667000													26	83					2.20474e-14	2.96231e-14	0.064281	1	0
CDH18	1016	broad.mit.edu	37	5	19591214	19591214	+	Silent	SNP	T	T	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:19591214T>A	ENST00000507958.1	-	9	1941	c.951A>T	c.(949-951)tcA>tcT	p.S317S	CDH18_ENST00000511273.1_Silent_p.S317S|CDH18_ENST00000274170.4_Silent_p.S317S|CDH18_ENST00000502796.1_Silent_p.S317S|CDH18_ENST00000506372.1_Silent_p.S317S|CDH18_ENST00000382275.1_Silent_p.S317S			Q13634	CAD18_HUMAN	cadherin 18, type 2	317	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CAGTGGAGATTGAGAATATTC	0.403000													25	31					0	0	0.108266	0	0
VDR	7421	broad.mit.edu	37	12	48240466	48240466	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:48240466T>A	ENST00000229022.3	-	9	1162	c.881A>T	c.(880-882)aAg>aTg	p.K294M	VDR_ENST00000549336.1_Missense_Mutation_p.K294M|VDR_ENST00000395324.2_Missense_Mutation_p.K294M|VDR_ENST00000550325.1_Missense_Mutation_p.K344M|VDR_ENST00000535672.1_Missense_Mutation_p.K262M	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	294	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	GACGCGGTACTTGTAGTCTTG	0.542000													12	38					0	0	0.093190	0	0
ALK	238	broad.mit.edu	37	2	29940451	29940451	+	Silent	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:29940451G>A	ENST00000389048.3	-	2	1686	c.780C>T	c.(778-780)agC>agT	p.S260S	ALK_ENST00000431873.1_Silent_p.S260S	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	260					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TACCATATCGGCTGCGATGAG	0.393000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				27	38					0	0	0.108266	0	0
GGCX	2677	broad.mit.edu	37	2	85777682	85777682	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:85777682G>C	ENST00000233838.3	-	14	2160	c.2080C>G	c.(2080-2082)Cgc>Ggc	p.R694G	GGCX_ENST00000430215.3_Missense_Mutation_p.R637G	NM_000821.5	NP_000812.2	P38435	VKGC_HUMAN	gamma-glutamyl carboxylase	694					blood coagulation|peptidyl-glutamic acid carboxylation|post-translational protein modification	endoplasmic reticulum membrane|integral to membrane|membrane fraction	gamma-glutamyl carboxylase activity			endometrium(3)|large_intestine(5)|lung(3)|ovary(1)|stomach(1)|urinary_tract(2)	15					Anisindione(DB01125)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Drotrecogin alfa(DB00055)|L-Glutamic Acid(DB00142)|Menadione(DB00170)|Phytonadione(DB01022)	ACTTACCTGCGGCGAAAGACA	0.468000													29	63					0	0	0.034045	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13093	13093	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrM:13093G>A	ENST00000361567.2	+	1	757	c.757G>A	c.(757-759)Gtt>Att	p.V253I				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	253			V -> A (in MT-C1D).		mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	CAAGCACTATAGTTGTAGCAG	0.522000													12	579					0	0	0.049695	0	0
GPANK1	7918	broad.mit.edu	37	6	31630177	31630177	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:31630177C>A	ENST00000375906.1	-	4	1621	c.937G>T	c.(937-939)Gat>Tat	p.D313Y	GPANK1_ENST00000375893.2_Missense_Mutation_p.D313Y|GPANK1_ENST00000375900.4_Missense_Mutation_p.D313Y|GPANK1_ENST00000375896.4_Missense_Mutation_p.D313Y|GPANK1_ENST00000375895.2_Missense_Mutation_p.D313Y	NM_001199237.1	NP_001186166.1	O95872	GPAN1_HUMAN	G patch domain and ankyrin repeats 1	313						intracellular	nucleic acid binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(7)	12						GCTCGGGTATCCCAAGCTGGG	0.632000													5	17					0.000157383	0.000176478	0.038147	1	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													3	31					0	0	0.004672	0	0
BAZ2B	29994	broad.mit.edu	37	2	160243034	160243034	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:160243034G>A	ENST00000392783.2	-	22	3796	c.3301C>T	c.(3301-3303)Cga>Tga	p.R1101*	AC008277.1_ENST00000420020.1_RNA|BAZ2B_ENST00000392782.1_Nonsense_Mutation_p.R1065*|BAZ2B_ENST00000355831.2_Nonsense_Mutation_p.R1067*|BAZ2B_ENST00000343439.5_Nonsense_Mutation_p.R1001*	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1101	DDT.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						CCAAAGTTTCGTAAGAACTGC	0.413000													13	50					0	0	0.024245	0	0
GKAP1	80318	broad.mit.edu	37	9	86357514	86357514	+	Splice_Site	SNP	C	C	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:86357514C>T	ENST00000376371.2	-	11	1306	c.904_splice	c.e11-1	p.M302_splice	GKAP1_ENST00000376362.1_5'UTR|GKAP1_ENST00000376365.3_Splice_Site_p.M251_splice	NM_025211.3	NP_079487.2	Q5VSY0	GKAP1_HUMAN	G kinase anchoring protein 1	302					signal transduction	Golgi apparatus				endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)	14						CCTTATCTTTCACTGACAAAA	0.368000													4	26					0	0	0.009096	0	0
PPP2R5D	5528	broad.mit.edu	37	6	42976964	42976964	+	Splice_Site	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:42976964A>T	ENST00000485511.1	+	11	1429	c.1251_splice	c.e11+1	p.Q417_splice	PPP2R5D_ENST00000461010.1_Splice_Site_p.Q311_splice|PPP2R5D_ENST00000394110.3_Splice_Site_p.Q385_splice|PPP2R5D_ENST00000472118.1_Splice_Site_p.Q409_splice	NM_001270476.1|NM_006245.3	NP_001257405.1|NP_006236.1	Q14738	2A5D_HUMAN	protein phosphatase 2, regulatory subunit B', delta	417					nervous system development|signal transduction	cytoplasm|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	25			Colorectal(64;0.00237)|all cancers(41;0.00411)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0664)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCCCATTTCCAGGTGAGACTC	0.557000											OREG0017447	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	65					0	0	0.048971	0	0
TLN2	83660	broad.mit.edu	37	15	63040641	63040641	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:63040641G>A	ENST00000561311.1	+	32	4347	c.4117G>A	c.(4117-4119)Gag>Aag	p.E1373K	TLN2_ENST00000306829.6_Missense_Mutation_p.E1373K			Q9Y4G6	TLN2_HUMAN	talin 2	1373					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						GCGGGAGCTCGAGGTAGGTCC	0.537000													14	57					0	0	0.020292	0	0
C1orf141	400757	broad.mit.edu	37	1	67561035	67561035	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:67561035A>T	ENST00000371007.2	-	7	595	c.486T>A	c.(484-486)agT>agA	p.S162R	C1orf141_ENST00000371006.1_Missense_Mutation_p.S162R|C1orf141_ENST00000544837.1_Missense_Mutation_p.S162R	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	162										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						ACCTATACTTACTTAATTGAT	0.338000													5	11					0	0	0.014758	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459862	66459862	+	RNA	SNP	T	T	C	rs142101130	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:66459862T>C	ENST00000424345.1	+	0	122																											ttttcctggatggtgttgatg	0.363000													4	35					0	0	0.009096	0	0
RGS22	26166	broad.mit.edu	37	8	101078438	101078438	+	Silent	SNP	T	T	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:101078438T>C	ENST00000360863.6	-	7	875	c.681A>G	c.(679-681)gtA>gtG	p.V227V	RGS22_ENST00000523287.1_Silent_p.V46V|RGS22_ENST00000523437.1_Silent_p.V215V	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	227					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			TGTTGTAGGGTACACAACAGG	0.363000													8	41					0	0	0.058154	0	0
LHCGR	3973	broad.mit.edu	37	2	48915565	48915565	+	Silent	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:48915565G>T	ENST00000294954.7	-	11	1392	c.1371C>A	c.(1369-1371)ctC>ctA	p.L457L	STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000405626.1_Silent_p.L430L|LHCGR_ENST00000401907.1_Intron|LHCGR_ENST00000344775.3_Silent_p.L395L|LHCGR_ENST00000403273.1_3'UTR	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	457			L -> R (in FMPP).		male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	TGATGACGGTGAGGGTGTAGA	0.478000													38	104					8.73648e-17	1.20571e-16	0.069456	1	0
CC2D2A	57545	broad.mit.edu	37	4	15504503	15504503	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:15504503G>T	ENST00000424120.1	+	6	649	c.395G>T	c.(394-396)cGa>cTa	p.R132L	CC2D2A_ENST00000513811.1_3'UTR|CC2D2A_ENST00000413206.1_Missense_Mutation_p.R132L|CC2D2A_ENST00000503292.1_Missense_Mutation_p.R132L|CC2D2A_ENST00000389652.5_Missense_Mutation_p.R83L			Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A	132					cell projection organization	cilium|microtubule basal body		p.R83Q(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|urinary_tract(2)	32						AGACGCTTACGAAGTCCCAGT	0.418000													9	16					0.000673444	0.000746911	0.069234	1	0
VPS13D	55187	broad.mit.edu	37	1	12566973	12566973	+	Silent	SNP	G	G	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:12566973G>A	ENST00000358136.3	+	69	12991	c.12861G>A	c.(12859-12861)ctG>ctA	p.L4287L	VPS13D_ENST00000471923.1_5'UTR|VPS13D_ENST00000543710.1_Silent_p.L91L|VPS13D_ENST00000496628.1_3'UTR|VPS13D_ENST00000356315.4_Silent_p.L4262L|VPS13D_ENST00000543766.1_Silent_p.L285L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	4286					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTTACTTCCTGAAAAGTGGAG	0.493000													11	35					0	0	0.069234	0	0
LOC101928460	101928460	broad.mit.edu	37	1	29667679	29667679	+	RNA	DEL	G	G	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:29667679delG	ENST00000417651.1	-	0	432																											ttttttttttgttttgttttg	0.438													4	2	---	---	---	---					
RP5-1198O20.4	0	broad.mit.edu	37	1	44537841	44537841	+	RNA	DEL	T	T	-	rs35296865		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:44537841delT	ENST00000434244.1	+	0	930																											ggaacccaggttttttttttt	0.438													4	2	---	---	---	---					
GNG12-AS1	100289178	broad.mit.edu	37	1	68372385	68372385	+	RNA	DEL	T	T	-	rs147868269		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:68372385delT	ENST00000420587.1	+	0	134				GNG12-AS1_ENST00000413628.1_RNA	NR_040077.1		Q6ZVV5	Q6ZVV5_HUMAN																			tttgaggcagttttttttttg	0.368													3	5	---	---	---	---					
RP4-714D9.5	0	broad.mit.edu	37	1	100496224	100496225	+	RNA	DEL	TG	TG	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:100496224_100496225delTG	ENST00000564623.1	+	0	103_104																											ACACAAAATCTGTGTGTGTGTG	0.332													2	4	---	---	---	---					
RP11-202K23.1	0	broad.mit.edu	37	1	102843938	102843938	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:102843938delA	ENST00000447916.1	-	0	339																											TAAATGAGTGAAAAATATAAG	0.299													2	4	---	---	---	---					
LINC01525	104355292	broad.mit.edu	37	1	117840123	117840124	+	RNA	INS	-	-	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:117840123_117840124insA	ENST00000442182.1	+	0	298																											aactccgtctcaaaaaaaaaaa	0.396													2	4	---	---	---	---					
LOC101927648	101927648	broad.mit.edu	37	1	143451865	143451866	+	RNA	INS	-	-	AT	rs141878771		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:143451865_143451866insAT	ENST00000423249.1	-	0	59																											aaaaaaaaaaaaaaaaaacaaa	0.386													2	4	---	---	---	---					
LOC400794	400794	broad.mit.edu	37	1	165537915	165537916	+	RNA	INS	-	-	A	rs35877698	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:165537915_165537916insA	ENST00000438275.1	-	0	932				RP11-280O1.2_ENST00000421273.1_RNA|RP11-280O1.2_ENST00000416424.1_RNA																							gataggagatgaaaaaaaaact	0.351													3	4	---	---	---	---					
LINC00970	101978719	broad.mit.edu	37	1	169001336	169001337	+	RNA	DEL	TC	TC	-	rs71736072		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:169001336_169001337delTC	ENST00000366408.3	-	0	209																											tcttcttctttctctctctctc	0.441													5	7	---	---	---	---					
RP11-373J16.1	0	broad.mit.edu	37	1	189005853	189005854	+	RNA	INS	-	-	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:189005853_189005854insC	ENST00000445072.1	+	0	244_245																											ccccagaattgccCCcctgggg	0.416													2	4	---	---	---	---					
CTD-2090I13.1	0	broad.mit.edu	37	1	227597661	227597661	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr1:227597661delT	ENST00000445817.1	+	0	340																											TGACCATTTCTTTTTTTTTAA	0.333													4	7	---	---	---	---					
AC008069.1	0	broad.mit.edu	37	2	16916657	16916658	+	RNA	INS	-	-	AGAA	rs10675465	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:16916657_16916658insAGAA	ENST00000448650.1	+	0	56																											CAAAGAGAGGTAGGCCCCTGTG	0.475													2	4	---	---	---	---					
AC012593.1	0	broad.mit.edu	37	2	35083953	35083956	+	RNA	DEL	CAGA	CAGA	-	rs147807518		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:35083953_35083956delCAGA	ENST00000588944.1	+	0	115																											ataccaaaaccagacaaagaccca	0.299													6	0	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	59780942	59780942	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:59780942delA	ENST00000606382.1	-	0	236																											tgggcggatcacttgagcctg	0.507													2	4	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	59858908	59858908	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:59858908delT	ENST00000606382.1	-	0	236																											gatttaattcttttttatggc	0.368													2	4	---	---	---	---					
LOC101929231	101929231	broad.mit.edu	37	2	150470187	150470188	+	RNA	INS	-	-	GTGC			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:150470187_150470188insGTGC	ENST00000449714.1	+	0	655																											tgtgtgtgtgtgcgtgtgcgtg	0.356													5	2	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	165126276	165126276	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:165126276delT	ENST00000429636.1	-	0	104																											cttaatttgcttaggacaatg	0.368													2	4	---	---	---	---					
LINC00607	646324	broad.mit.edu	37	2	216619195	216619195	+	RNA	DEL	C	C	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:216619195delC	ENST00000445174.1	-	0	211					NR_037195.1																						ttaagtgctgctcaaaagctt	0.383													2	4	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217560771	217560772	+	RNA	DEL	GT	GT	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:217560771_217560772delGT	ENST00000447289.1	+	0	298																											TCCATGTGGGGTGTGTGTGTGT	0.421													2	4	---	---	---	---					
AC097713.3	0	broad.mit.edu	37	2	235367136	235367137	+	RNA	DEL	CG	CG	-	rs141075144		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:235367136_235367137delCG	ENST00000418025.1	+	0	188																											tccttccccccgccggtcccca	0.530													3	3	---	---	---	---					
AC113618.1	0	broad.mit.edu	37	2	239639784	239639784	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr2:239639784delA	ENST00000448543.1	+	0	98																											CTGGCAAGTTAAAAAAAAAAA	0.348													3	3	---	---	---	---					
LMCD1-AS1	100288428	broad.mit.edu	37	3	8652218	8652219	+	RNA	DEL	TG	TG	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:8652218_8652219delTG	ENST00000458666.1	-	0	426				LMCD1-AS1_ENST00000439407.1_RNA																							ATATACATGTTGTGTGTGTGTA	0.411													2	4	---	---	---	---					
LINC00882	100302640	broad.mit.edu	37	3	106822402	106822403	+	RNA	INS	-	-	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:106822402_106822403insT	ENST00000484698.1	-	0	295																											GCAACTTCTACTTTTGCTAATA	0.460													2	4	---	---	---	---					
LINC00636	285205	broad.mit.edu	37	3	107621270	107621270	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:107621270delT	ENST00000494231.1	+	0	59					NR_015394.1																						agctttgttctttttgcttag	0.338													2	4	---	---	---	---					
RP11-200A1.1	0	broad.mit.edu	37	3	134039247	134039248	+	RNA	INS	-	-	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:134039247_134039248insA	ENST00000482019.1	+	0	42																											GGGAGTCTTACAAAAAAAAAAG	0.302													2	4	---	---	---	---					
RP11-501O2.5	0	broad.mit.edu	37	3	148078586	148078587	+	RNA	DEL	AT	AT	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:148078586_148078587delAT	ENST00000481334.1	+	0	106																											tgtccttgcgatagtttgctca	0.416													4	8	---	---	---	---					
AADACL2-AS1	101928142	broad.mit.edu	37	3	151578589	151578589	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:151578589delT	ENST00000483843.2	-	0	439				RP11-454C18.2_ENST00000475855.1_RNA																							ATGCCCTGCCTACAACTTAGT	0.373													2	4	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153258149	153258149	+	RNA	DEL	G	G	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:153258149delG	ENST00000493214.2	-	0	260																											TAATTAACATGGTGATAGCAC	0.328													2	4	---	---	---	---					
RP11-298O21.2	0	broad.mit.edu	37	3	167594669	167594674	+	RNA	DEL	TGTGTG	TGTGTG	-	rs57722183		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:167594669_167594674delTGTGTG	ENST00000475324.1	+	0	282				RP11-298O21.6_ENST00000463642.1_lincRNA																							GAGgtgtgcttgtgtgtgtgtgtgtg	0.432													2	4	---	---	---	---					
LINC01330	646168	broad.mit.edu	37	3	167616888	167616888	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:167616888delT	ENST00000481578.1	+	0	137																											CATGCTTTCCTTCCTTCTAAA	0.363													2	4	---	---	---	---					
LINC00578	100505566	broad.mit.edu	37	3	177255583	177255584	+	RNA	INS	-	-	CA	rs141426881	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:177255583_177255584insCA	ENST00000442937.1	+	0	190					NR_047568.1																						TGAAAGTGCTCCAGTGTCACTT	0.475													3	5	---	---	---	---					
LOC101929106	101929106	broad.mit.edu	37	3	186921739	186921739	+	RNA	DEL	T	T	-	rs140101149	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:186921739delT	ENST00000356133.3	-	0	344																											AGTTTCTGACTTTTGCAGTCC	0.418													2	4	---	---	---	---					
SDHAP1	255812	broad.mit.edu	37	3	195701310	195701311	+	RNA	INS	-	-	AA			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr3:195701310_195701311insAA	ENST00000427841.1	-	0	1513_1514					NR_003264.2																						CATGCCTGACCAGACAACCAGG	0.574													9	114	---	---	---	---					
LOC256880	256880	broad.mit.edu	37	4	100910774	100910775	+	RNA	INS	-	-	CA	rs143996847	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:100910774_100910775insCA	ENST00000507494.1	+	0	191				RP11-15B17.1_ENST00000501976.2_RNA																							cccctggcaacccattctgtct	0.376													3	3	---	---	---	---					
RP11-556I14.2	0	broad.mit.edu	37	4	105773374	105773374	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:105773374delT	ENST00000515127.1	-	0	366																											ttgggttttgttttttaatcc	0.313													2	4	---	---	---	---					
RP11-284M14.1	0	broad.mit.edu	37	4	144041311	144041312	+	RNA	DEL	CA	CA	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:144041311_144041312delCA	ENST00000507826.1	-	0	354																											caaaggttgtcacaatgcctga	0.332													2	4	---	---	---	---					
RP11-285C1.2	0	broad.mit.edu	37	4	153971300	153971300	+	RNA	DEL	A	A	-	rs71598231		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:153971300delA	ENST00000515232.1	+	0	218																											aagtctctacaaaaaaataca	0.483													2	4	---	---	---	---					
LOC100506085	100506085	broad.mit.edu	37	4	170887159	170887163	+	RNA	DEL	CAAAA	CAAAA	-	rs7659042	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:170887159_170887163delCAAAA	ENST00000508313.1	-	0	87					NR_037878.1																						GTTCTTGaagcaaaacaaaacaaaa	0.395													4	6	---	---	---	---					
LOC100506085	100506085	broad.mit.edu	37	4	170888757	170888759	+	RNA	DEL	AAC	AAC	-	rs148791379		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:170888757_170888759delAAC	ENST00000508313.1	-	0	87					NR_037878.1																						AAAAAAAAAAAACAAAAACTGAT	0.241													8	0	---	---	---	---					
LINC01098	285501	broad.mit.edu	37	4	178911644	178911644	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr4:178911644delA	ENST00000507870.1	+	6	774	c.312delA	c.(310-312)ttfs	p.L104fs																	lung(8)|prostate(1)	9						TTCAAGCATTAAGCACTGTGC	0.393													14	36	---	---	---	---					
LINC01019	285577	broad.mit.edu	37	5	3446822	3446824	+	RNA	DEL	TGA	TGA	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:3446822_3446824delTGA	ENST00000505443.1	-	0	459					NR_033898.1																						gtggtgatggtgatgatgatggt	0.473													7	2	---	---	---	---					
LOC100505625	100505625	broad.mit.edu	37	5	6687787	6687790	+	RNA	DEL	CACT	CACT	-	rs61338104		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:6687787_6687790delCACT	ENST00000503989.1	-	0	2756					NR_103771.1																						atatcactcacactcagtcacacc	0.475													3	3	---	---	---	---					
TRIO	7204	broad.mit.edu	37	5	14487780	14487781	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:14487780_14487781insC	ENST00000344204.4	+	48	7067_7068	c.7043_7044insC	c.(7042-7044)cccfs	p.P2348fs	TRIO_ENST00000537187.1_Frame_Shift_Ins_p.P2348fs	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2348					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					GTCCGACACCACCCCCCCGTGC	0.748													2	4	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21559505	21559506	+	RNA	INS	-	-	CA	rs149099655	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:21559505_21559506insCA	ENST00000607545.1	+	0	314					NR_027026.1																						TCAATAGACtgtagtatgttcg	0.356													4	3	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21564316	21564317	+	RNA	DEL	TC	TC	-	rs71607535		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:21564316_21564317delTC	ENST00000607545.1	+	0	314					NR_027026.1																						AAGGAGCCTTTCTCTGCCTGAA	0.361													3	3	---	---	---	---					
LIFR-AS1	100506495	broad.mit.edu	37	5	38596646	38596647	+	RNA	DEL	AG	AG	-	rs151228908		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:38596646_38596647delAG	ENST00000500733.2	+	0	2540				LIFR-AS1_ENST00000500817.2_RNA	NR_037423.1|NR_103553.1																						ctgctggactagagaccacact	0.465													6	0	---	---	---	---					
CTD-2023N9.2	0	broad.mit.edu	37	5	56878730	56878730	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:56878730delA	ENST00000513392.1	+	0	244																											TAGCAGCTTTAAAAAAAAAAT	0.438													2	4	---	---	---	---					
RP11-60A8.1	0	broad.mit.edu	37	5	72542103	72542104	+	RNA	DEL	GC	GC	-	rs36124854		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:72542103_72542104delGC	ENST00000513379.1	+	0	328																											ACATGCGCGTGCGCGCGCGCGc	0.485													5	1	---	---	---	---					
ZBED3-AS1	728723	broad.mit.edu	37	5	76419181	76419182	+	RNA	INS	-	-	C	rs143726317	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:76419181_76419182insC	ENST00000513591.1	+	0	865				ZBED3-AS1_ENST00000515419.1_RNA|ZBED3-AS1_ENST00000502433.1_RNA|ZBED3-AS1_ENST00000514905.1_RNA|ZBED3-AS1_ENST00000508401.1_RNA|ZBED3-AS1_ENST00000514114.1_RNA|ZBED3-AS1_ENST00000512001.1_RNA|ZBED3-AS1_ENST00000513406.1_RNA|ZBED3-AS1_ENST00000504506.1_RNA|ZBED3-AS1_ENST00000507749.1_RNA|ZBED3-AS1_ENST00000503969.1_RNA																							gttgaattcctcccccaccgcc	0.460													2	4	---	---	---	---					
MEF2C-AS1	101929423	broad.mit.edu	37	5	88425194	88425194	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:88425194delT	ENST00000512585.1	+	0	202				MEF2C-AS1_ENST00000514571.1_RNA|MEF2C-AS1_ENST00000514092.1_RNA																							TCTGTCAGCCTTCCTTATTAT	0.398													2	4	---	---	---	---					
RP11-254I22.1	0	broad.mit.edu	37	5	95533467	95533468	+	RNA	INS	-	-	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:95533467_95533468insT	ENST00000507997.1	+	0	159				CTD-2337A12.1_ENST00000511775.1_RNA|CTD-2337A12.1_ENST00000502645.2_RNA																							CAACCTAGACAtttttttgtgt	0.485													2	4	---	---	---	---					
LINC01340	102546227	broad.mit.edu	37	5	96847371	96847377	+	RNA	DEL	CCTATGG	CCTATGG	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:96847371_96847377delCCTATGG	ENST00000504012.1	+	0	97																											ctctcacctacctatggcctggaagtc	0.440													2	4	---	---	---	---					
LOC101927115	101927115	broad.mit.edu	37	5	151532834	151532835	+	RNA	DEL	TG	TG	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:151532834_151532835delTG	ENST00000524295.1	+	0	199																											gctttttatatgtgtgtgtgtg	0.381													2	4	---	---	---	---					
RP11-541P9.3	0	broad.mit.edu	37	5	162514093	162514094	+	RNA	INS	-	-	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:162514093_162514094insA	ENST00000509211.1	-	0	219				RP11-541P9.3_ENST00000458002.2_RNA																							TTTCCATTTGGAAAAAAAAAGT	0.307													2	4	---	---	---	---					
CTC-535M15.2	0	broad.mit.edu	37	5	165026516	165026517	+	RNA	INS	-	-	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:165026516_165026517insT	ENST00000522189.1	+	0	21																											tacagcacaacttttttttttt	0.361													3	3	---	---	---	---					
CTD-2532K18.1	0	broad.mit.edu	37	5	174256314	174256315	+	RNA	INS	-	-	T	rs68084293		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr5:174256314_174256315insT	ENST00000502684.1	+	0	50																											TCCAGTGGCTCTTTTTTTTTTT	0.347													4	3	---	---	---	---					
ZNRD1-AS1	80862	broad.mit.edu	37	6	29987533	29987534	+	RNA	INS	-	-	A	rs9280845	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:29987533_29987534insA	ENST00000444051.1	-	0	2112_2113				ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000376797.3_RNA|ZNRD1-AS1_ENST00000448093.1_RNA	NR_103542.1																						tctttactgacaactagatttg	0.480													3	3	---	---	---	---					
LOC101928516	101928516	broad.mit.edu	37	6	74912077	74912077	+	RNA	DEL	T	T	-	rs112680600		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr6:74912077delT	ENST00000435946.1	+	0	138																											tttgttgggatttttttttta	0.303													2	4	---	---	---	---					
LOC100505938	100505938	broad.mit.edu	37	7	8351813	8351813	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:8351813delT	ENST00000424460.1	+	0	493				RP4-594A5.1_ENST00000435967.1_lincRNA																							tttccacccctttaccttgag	0.358													2	4	---	---	---	---					
AC007091.1	0	broad.mit.edu	37	7	19613595	19613595	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:19613595delA	ENST00000412563.1	+	0	356																											actgtagaagaaaagcctgaa	0.433													2	4	---	---	---	---					
AC004009.3	0	broad.mit.edu	37	7	27446565	27446566	+	RNA	INS	-	-	GATGT	rs149252430	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:27446565_27446566insGATGT	ENST00000412413.1	+	0	399																											aggagtccagggagcagcctct	0.550													2	4	---	---	---	---					
STEAP2-AS1	100874100	broad.mit.edu	37	7	89570560	89570560	+	RNA	DEL	C	C	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:89570560delC	ENST00000478318.2	-	0	424																											tggagtaaaaccctggctgct	0.378													2	4	---	---	---	---					
GAL3ST4	79690	broad.mit.edu	37	7	99758298	99758299	+	Frame_Shift_Ins	INS	-	-	G	rs149033197	byFrequency	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:99758298_99758299insG	ENST00000360039.4	-	4	1105_1106	c.713_714insC	c.(712-714)ccafs	p.P238fs	GAL3ST4_ENST00000411994.1_Frame_Shift_Ins_p.Q137fs|GAL3ST4_ENST00000413800.1_Frame_Shift_Ins_p.P238fs|GAL3ST4_ENST00000426974.2_Frame_Shift_Ins_p.P176fs|GAL3ST4_ENST00000423751.1_Frame_Shift_Ins_p.Q137fs	NM_024637.4	NP_078913.3	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	238					cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(5)|prostate(1)|upper_aerodigestive_tract(1)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCTGCAGCTGTGGGGGGTTGGG	0.564													7	414	---	---	---	---					
COL26A1	136227	broad.mit.edu	37	7	101040812	101040813	+	RNA	INS	-	-	C	rs145665554	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:101040812_101040813insC	ENST00000313669.7	+	0	350				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		ccttctctcctccccccccctc	0.525													2	4	---	---	---	---					
AC004014.3	0	broad.mit.edu	37	7	108557140	108557140	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:108557140delT	ENST00000413406.1	+	0	75																											tattcctaagttttttttttt	0.373													4	3	---	---	---	---					
AC004014.3	0	broad.mit.edu	37	7	108576408	108576408	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:108576408delA	ENST00000413406.1	+	0	75																											ttatatcactaatcatcaggg	0.299													2	4	---	---	---	---					
ZNF767	79970	broad.mit.edu	37	7	149267422	149267425	+	RNA	DEL	AGAG	AGAG	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:149267422_149267425delAGAG	ENST00000463567.1	-	0	600					NR_027788.1				zinc finger family member 767											central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(1)	5	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00434)			ACGGGATGACagagagagagagag	0.505													2	4	---	---	---	---					
C7orf13	129790	broad.mit.edu	37	7	156282032	156282033	+	RNA	INS	-	-	AGAC	rs28562054	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr7:156282032_156282033insAGAC	ENST00000447933.1	-	0	300																											ataagatagatagatagacaga	0.381													5	1	---	---	---	---					
RP11-388G22.1	0	broad.mit.edu	37	8	58544068	58544069	+	RNA	INS	-	-	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:58544068_58544069insC	ENST00000520426.1	-	0	273																											CTCTATACCTACCCCCAAAGCT	0.416													2	4	---	---	---	---					
CTD-3118D11.3	0	broad.mit.edu	37	8	87213066	87213066	+	RNA	DEL	G	G	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:87213066delG	ENST00000523112.1	+	0	459																											AGTAAGGCATGGATGTCTGAG	0.333													3	4	---	---	---	---					
LINC00534	100874052	broad.mit.edu	37	8	91357773	91357774	+	RNA	INS	-	-	A	rs35932905		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:91357773_91357774insA	ENST00000523406.1	+	0	300					NR_051989.1																						ATAGGAAATGGAAAAAAAAAAA	0.436													3	4	---	---	---	---					
C8orf37-AS1	100616530	broad.mit.edu	37	8	96370154	96370154	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:96370154delA	ENST00000521905.1	+	0	126																											AGGTGTTTAGAAGTTGGTTGT	0.517													2	4	---	---	---	---					
RP11-1084E5.1	0	broad.mit.edu	37	8	109920931	109920931	+	RNA	DEL	C	C	-	rs78437633		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:109920931delC	ENST00000524134.1	-	0	431				RP11-1084E5.1_ENST00000522244.1_RNA																							CTGTTTTTTTCCCCCCAATTA	0.393													2	4	---	---	---	---					
RP11-149P24.1	0	broad.mit.edu	37	8	137173788	137173789	+	RNA	INS	-	-	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr8:137173788_137173789insT	ENST00000523150.1	+	0	330																											CACACACAttcttttttttttt	0.431													2	4	---	---	---	---					
VLDLR-AS1	401491	broad.mit.edu	37	9	2480436	2480437	+	RNA	INS	-	-	T	rs57040683	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:2480436_2480437insT	ENST00000416826.2	-	0	1214																											tggtgttctcatactttctctc	0.411													2	4	---	---	---	---					
MIR31HG	554202	broad.mit.edu	37	9	21494917	21494918	+	RNA	INS	-	-	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:21494917_21494918insT	ENST00000304425.3	-	0	181					NR_027054.1																						ACGAGCATCTCTTTTTTTCTAA	0.386													2	4	---	---	---	---					
LINC01239	441389	broad.mit.edu	37	9	22817441	22817442	+	RNA	INS	-	-	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:22817441_22817442insG	ENST00000436786.1	+	0	524					NR_038977.1																						GATTAGGGGTTGGGGGGAAGGT	0.406													2	4	---	---	---	---					
RP11-162D16.2	0	broad.mit.edu	37	9	124171967	124171968	+	RNA	INS	-	-	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:124171967_124171968insT	ENST00000440807.1	+	0	85																											tagttggcttctttttgccttt	0.366													2	4	---	---	---	---					
RP11-343J18.2	0	broad.mit.edu	37	9	128853019	128853020	+	RNA	INS	-	-	G	rs34835338	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr9:128853019_128853020insG	ENST00000441473.1	+	0	235																											TATTCTGGGTTGGGGGGGACCA	0.505													4	6	---	---	---	---					
LINC00708	100507143	broad.mit.edu	37	10	8305896	8305896	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:8305896delA	ENST00000428165.1	-	0	271																											aaatttcattaaaaaaaaaaa	0.473													4	3	---	---	---	---					
RP11-543F8.2	0	broad.mit.edu	37	10	8469388	8469389	+	RNA	DEL	AA	AA	-	rs61622451		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:8469388_8469389delAA	ENST00000413286.1	+	0	141																											TCCTATATCCAAAAAAAAAAAA	0.441													2	4	---	---	---	---					
TMEM72-AS1	220980	broad.mit.edu	37	10	45399946	45399947	+	RNA	INS	-	-	A	rs147150139		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:45399946_45399947insA	ENST00000450287.2	-	0	244				RP11-285G1.2_ENST00000436877.2_RNA	NR_033842.1																						gactccatcttaaaaaaaaaaa	0.520													2	4	---	---	---	---					
LINC01468	101928687	broad.mit.edu	37	10	54212419	54212419	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:54212419delT	ENST00000435813.2	-	0	331																											ATTTGTAAGATTTTTGAGCTG	0.413													2	4	---	---	---	---					
RP11-170M17.1	0	broad.mit.edu	37	10	65699694	65699695	+	RNA	DEL	AG	AG	-	rs34364511		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:65699694_65699695delAG	ENST00000444770.1	+	0	494																											GGGACATGACAGAGAGTAACTG	0.391													3	4	---	---	---	---					
RP11-432J9.6	0	broad.mit.edu	37	10	72705640	72705641	+	RNA	INS	-	-	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:72705640_72705641insC	ENST00000560700.1	+	0	128																											tagcacatgcacccccccaagg	0.594													2	4	---	---	---	---					
ZNF503-AS1	253264	broad.mit.edu	37	10	77107149	77107150	+	RNA	INS	-	-	AA	rs35170209	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:77107149_77107150insAA	ENST00000416398.1	+	0	262				RP11-399K21.11_ENST00000418818.2_lincRNA	NR_038223.1																						GCAGGGCTGACGAGAGGAGAAC	0.559													4	5	---	---	---	---					
RP11-245J24.1	0	broad.mit.edu	37	10	120013763	120013764	+	RNA	INS	-	-	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:120013763_120013764insT	ENST00000436430.1	+	0	263																											TGGGGAGGGGAGGGGAGACAGG	0.460													3	5	---	---	---	---					
RP11-282I1.1	0	broad.mit.edu	37	10	125150650	125150650	+	RNA	DEL	C	C	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr10:125150650delC	ENST00000448347.1	+	0	586																											TGTAGTTCATCCCCTGGCTGG	0.567													8	2	---	---	---	---					
CYB5R2	51700	broad.mit.edu	37	11	7693706	7693706	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:7693706delC	ENST00000533558.1	-	3	683	c.127delG	c.(127-129)acfs	p.D43fs	CYB5R2_ENST00000524790.1_Frame_Shift_Del_p.D43fs|CYB5R2_ENST00000299497.9_Frame_Shift_Del_p.D43fs|CYB5R2_ENST00000299498.6_Frame_Shift_Del_p.D43fs			Q6BCY4	NB5R2_HUMAN	cytochrome b5 reductase 2	43	FAD-binding FR-type.				sterol biosynthetic process	membrane|soluble fraction	cytochrome-b5 reductase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)	11				Epithelial(150;5.48e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AAGACATGGTCCGGCGAAGGC	0.547													16	54	---	---	---	---					
LOC283299	283299	broad.mit.edu	37	11	7854683	7854685	+	RNA	DEL	ATC	ATC	-	rs35937916		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:7854683_7854685delATC	ENST00000527565.1	-	0	542																											tgatgcctgtatcatcattatat	0.409													3	6	---	---	---	---					
ZBED5-AS1	729013	broad.mit.edu	37	11	10921845	10921846	+	RNA	DEL	GT	GT	-	rs10596848		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:10921845_10921846delGT	ENST00000530344.1	+	0	67																											TGCtgtgtccgtgtgtgtgtgt	0.480													2	4	---	---	---	---					
RP5-1024C24.1	0	broad.mit.edu	37	11	30627839	30627839	+	RNA	DEL	A	A	-	rs76102461		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:30627839delA	ENST00000531002.1	+	0	297																											ctgtatcaagaaaaaaaaaaa	0.443													2	4	---	---	---	---					
RP11-124G5.3	0	broad.mit.edu	37	11	41581268	41581269	+	RNA	INS	-	-	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:41581268_41581269insA	ENST00000526978.1	-	0	519																											ccacagaaagtaaaaaaaaaag	0.351													2	4	---	---	---	---					
RP11-124G5.3	0	broad.mit.edu	37	11	41670427	41670428	+	RNA	INS	-	-	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:41670427_41670428insT	ENST00000526978.1	-	0	149																											gcaaaccctgcttttttttgct	0.371													2	4	---	---	---	---					
LOC101928989	101928989	broad.mit.edu	37	11	82340227	82340227	+	RNA	DEL	C	C	-	rs144658171	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:82340227delC	ENST00000527364.1	-	0	271																											aagcttgccgccccagccagc	0.473													2	4	---	---	---	---					
CTD-2216M2.1	0	broad.mit.edu	37	11	123078550	123078551	+	RNA	INS	-	-	T			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr11:123078550_123078551insT	ENST00000531681.1	+	0	305																											TTATAAGTTTGTTTTTttcctc	0.426													2	4	---	---	---	---					
CD27-AS1	678655	broad.mit.edu	37	12	6549381	6549381	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:6549381delA	ENST00000545339.1	-	0	1250				CD27-AS1_ENST00000399492.2_RNA																							caacatggtgaaaccacgtct	0.507													2	4	---	---	---	---					
SSPN	8082	broad.mit.edu	37	12	26278872	26278873	+	RNA	INS	-	-	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:26278872_26278873insC	ENST00000545819.1	-	0	219				RP11-283G6.3_ENST00000535914.1_RNA																							CCATCCCCCCGCCCCCCCGCGC	0.619													2	4	---	---	---	---					
ANP32D	23519	broad.mit.edu	37	12	48866596	48866597	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:48866596_48866597insA	ENST00000266594.1	+	1	149_150	c.149_150insA	c.(148-150)aaafs	p.K50fs		NM_012404.2	NP_036536.2	O95626	AN32D_HUMAN	acidic (leucine-rich) nuclear phosphoprotein 32 family, member D	50								p.I50T(1)		central_nervous_system(1)|large_intestine(2)|lung(3)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	9						TTAAATACAATCAACATAGGCC	0.396													40	180	---	---	---	---					
FLJ12825	440101	broad.mit.edu	37	12	54499109	54499110	+	RNA	INS	-	-	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:54499109_54499110insA	ENST00000515617.1	+	0	311					NR_026655.1																						cccatctctacaaaaaaagcaa	0.510													4	2	---	---	---	---					
RP11-150C16.1	0	broad.mit.edu	37	12	59344671	59344671	+	RNA	DEL	G	G	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:59344671delG	ENST00000547590.1	+	0	226																											tgtggtgccaggcaggaatga	0.473													2	4	---	---	---	---					
RP11-631N16.2	0	broad.mit.edu	37	12	63004718	63004721	+	RNA	DEL	TGTG	TGTG	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:63004718_63004721delTGTG	ENST00000550290.1	+	0	84																											TAACCTTCTTtgtgtgtgtgtgtg	0.407													3	6	---	---	---	---					
FLJ41278	400046	broad.mit.edu	37	12	65357789	65357789	+	RNA	DEL	G	G	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:65357789delG	ENST00000535058.1	+	0	594				RP11-766N7.4_ENST00000510459.2_lincRNA	NR_033988.1																						ttcaggagcaggttgctcaat	0.373													2	4	---	---	---	---					
IRAK3	11213	broad.mit.edu	37	12	66603295	66603295	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:66603295delT	ENST00000261233.4	+	3	797	c.376delT	c.(376-378)tcfs	p.F126fs	IRAK3_ENST00000457197.2_Frame_Shift_Del_p.F65fs	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	126					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		AAATATATTATTCAAGGTAGA	0.348													8	34	---	---	---	---					
NAV3	89795	broad.mit.edu	37	12	78400511	78400512	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:78400511_78400512insC	ENST00000397909.2	+	8	1366_1367	c.1193_1194insC	c.(1192-1194)cccfs	p.P398fs	NAV3_ENST00000228327.6_Frame_Shift_Ins_p.P398fs|NAV3_ENST00000266692.7_Frame_Shift_Ins_p.P398fs|NAV3_ENST00000536525.2_Frame_Shift_Ins_p.P398fs			Q8IVL0	NAV3_HUMAN	neuron navigator 3	398						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						ACTGCTTTACGCCCCCCGCAGC	0.495										HNSCC(70;0.22)			7	113	---	---	---	---					
RP11-536G4.2	0	broad.mit.edu	37	12	96231057	96231064	+	RNA	DEL	GAGGGAGA	GAGGGAGA	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:96231057_96231064delGAGGGAGA	ENST00000553194.1	-	0	86																											agagagggaggagggagagagggagaga	0.567													5	1	---	---	---	---					
FAM101A	144347	broad.mit.edu	37	12	124674432	124674433	+	RNA	INS	-	-	T	rs59449837		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:124674432_124674433insT	ENST00000540762.1	+	0	444																											cctcctctttcttttttttttt	0.510													3	4	---	---	---	---					
RP11-897M7.1	0	broad.mit.edu	37	12	131962424	131962426	+	RNA	DEL	GAT	GAT	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr12:131962424_131962426delGAT	ENST00000535133.1	-	0	195																											tgataatgaggatgatgatgata	0.384													2	4	---	---	---	---					
TPTE2P1	646405	broad.mit.edu	37	13	25539913	25539921	+	RNA	DEL	CCTCTGCCT	CCTCTGCCT	-	rs2991008		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr13:25539913_25539921delCCTCTGCCT	ENST00000429698.1	-	0	282																											ctcactgcaacctctgcctcctgggttca	0.431													2	4	---	---	---	---					
RP11-141M1.3	0	broad.mit.edu	37	13	34069185	34069186	+	RNA	INS	-	-	AGT	rs10689124	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr13:34069185_34069186insAGT	ENST00000454681.2	-	0	226																											TTTCCTGCCTACACTTCCGCTA	0.426													3	5	---	---	---	---					
RP11-16D22.2	0	broad.mit.edu	37	13	34981514	34981514	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr13:34981514delT	ENST00000605909.1	+	0	82																											tgattttttattaggatgaca	0.418													2	4	---	---	---	---					
LINC00559	100874187	broad.mit.edu	37	13	90719206	90719206	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr13:90719206delA	ENST00000569476.1	-	0	3418					NR_047489.1																						TCATTTATATAAATCATTTCC	0.269													2	4	---	---	---	---					
RP11-116N8.1	0	broad.mit.edu	37	14	36526759	36526759	+	RNA	DEL	T	T	-	rs111244625		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr14:36526759delT	ENST00000550089.1	+	0	417																											GGTCTCATACTTTTTTTTTTT	0.388													2	4	---	---	---	---					
RP11-305B6.3	0	broad.mit.edu	37	14	44743279	44743280	+	RNA	INS	-	-	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr14:44743279_44743280insG	ENST00000553827.1	-	0	69																											tggtaaaatgtggaaatgggag	0.381													2	4	---	---	---	---					
RP11-398E10.1	0	broad.mit.edu	37	14	45240432	45240432	+	RNA	DEL	G	G	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr14:45240432delG	ENST00000556405.1	-	0	275																											tgtaaacataggttttcattt	0.318													2	4	---	---	---	---					
RP11-61O1.1	0	broad.mit.edu	37	14	98539045	98539045	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr14:98539045delA	ENST00000555776.1	-	0	270																											ACCAAGATGTAAGTCTGAGTT	0.428													2	4	---	---	---	---					
HERC2P3	283755	broad.mit.edu	37	15	20631659	20631659	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:20631659delT	ENST00000428453.1	-	0	4041																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						gaggtttcacttttttttccc	0.338													3	6	---	---	---	---					
NBEAP1	606	broad.mit.edu	37	15	20873109	20873109	+	RNA	DEL	A	A	-	rs111264216		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:20873109delA	ENST00000556948.1	-	0	452																											gcaactttgtaacttttctgt	0.289													5	4	---	---	---	---					
LOC101927079	101927079	broad.mit.edu	37	15	22331642	22331643	+	RNA	INS	-	-	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:22331642_22331643insA	ENST00000558896.1	+	0	194																											ATAGTAAAGACAAAAAATATGA	0.317													3	3	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25483318	25483319	+	RNA	INS	-	-	G	rs140580374	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:25483318_25483319insG	ENST00000453082.2	+	0	1979					NR_003343.1																						GCGCATCTTGTGGGGGGGCAAT	0.579													4	4	---	---	---	---					
FMN1	342184	broad.mit.edu	37	15	33359176	33359176	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:33359176delC	ENST00000334528.9	-	1	909	c.910delG	c.(910-912)acfs	p.D304fs	FMN1_ENST00000561249.1_Intron|FMN1_ENST00000558197.1_Frame_Shift_Del_p.D304fs|FMN1_ENST00000559047.1_Intron|FMN1_ENST00000559150.1_Intron	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	405	Microtubule-binding (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		AAAGCTAAGTCCCCATCCTTT	0.512													10	34	---	---	---	---					
RP11-323I15.5	0	broad.mit.edu	37	15	35432323	35432324	+	RNA	INS	-	-	A	rs150961888		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:35432323_35432324insA	ENST00000559246.1	-	0	74																											agatcctgcctaaaaaaaaaaa	0.366													3	5	---	---	---	---					
DPH6-AS1	100507466	broad.mit.edu	37	15	35879914	35879915	+	RNA	DEL	TG	TG	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:35879914_35879915delTG	ENST00000501169.2	+	0	279					NR_038251.1																						ATTGTGAGCATGTGTGTGTGTG	0.406													4	2	---	---	---	---					
DPH6-AS1	100507466	broad.mit.edu	37	15	36087808	36087809	+	RNA	INS	-	-	AAAC	rs59103217	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:36087808_36087809insAAAC	ENST00000501169.2	+	0	462					NR_038251.1																						actccgtctcaaaacaaacaaa	0.460													6	2	---	---	---	---					
RP11-507B12.2	0	broad.mit.edu	37	15	61899439	61899450	+	RNA	DEL	AGGAAGGAAGGA	AGGAAGGAAGGA	-	rs76475731	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:61899439_61899450delAGGAAGGAAGGA	ENST00000559783.1	-	0	35																											catGAaagggaggaaggaaggaaggaaggaag	0.491													4	9	---	---	---	---					
LOC102723481	102723481	broad.mit.edu	37	15	67248462	67248463	+	RNA	INS	-	-	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:67248462_67248463insG	ENST00000558436.1	-	0	179																											tccctgtgcctgggggggcctg	0.564													2	4	---	---	---	---					
RP11-798K3.2	0	broad.mit.edu	37	15	67305872	67305873	+	RNA	INS	-	-	CC			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:67305872_67305873insCC	ENST00000558071.1	-	0	114																											CACTCCCCCCACCCCCCATCTA	0.460													2	4	---	---	---	---					
CTD-2034I4.1	0	broad.mit.edu	37	15	81746870	81746870	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:81746870delT	ENST00000559211.1	+	0	98																											tttctctctcttttttttttt	0.423													2	4	---	---	---	---					
LOC101926928	101926928	broad.mit.edu	37	15	92007011	92007014	+	RNA	DEL	TTGA	TTGA	-	rs150084691		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:92007011_92007014delTTGA	ENST00000554333.1	+	0	295																											gtatacatgtttgattattttctt	0.412													4	3	---	---	---	---					
RP11-152L20.3	0	broad.mit.edu	37	15	92810991	92810992	+	RNA	INS	-	-	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:92810991_92810992insC	ENST00000561674.1	-	0	185																											TCCTCTGACCACCCCCTTTAGA	0.411													2	4	---	---	---	---					
LINC01581	101927112	broad.mit.edu	37	15	94516968	94516969	+	RNA	INS	-	-	C	rs142439738	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:94516968_94516969insC	ENST00000558874.1	-	0	1765				CTD-2643K12.2_ENST00000555364.1_lincRNA																							ATTCATGATTTCCCCCCCCAGA	0.332													2	4	---	---	---	---					
LINC01581	101927112	broad.mit.edu	37	15	94592880	94592880	+	RNA	DEL	A	A	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr15:94592880delA	ENST00000558874.1	-	0	1141																											AAAAGTGACTAAAAAATCAGT	0.378													2	4	---	---	---	---					
LOC101927009	101927009	broad.mit.edu	37	16	9467302	9467302	+	RNA	DEL	G	G	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr16:9467302delG	ENST00000564305.1	+	0	193																											cccccatggtggggggggcgg	0.532													2	4	---	---	---	---					
CTA-481E9.4	0	broad.mit.edu	37	16	18061962	18061962	+	RNA	DEL	A	A	-	rs72396467		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr16:18061962delA	ENST00000567304.1	-	0	251																											GCAATCTTTTAAAAAAAAAAA	0.403													2	4	---	---	---	---					
RP11-252E2.2	0	broad.mit.edu	37	16	75155068	75155068	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr16:75155068delT	ENST00000563098.1	+	0	25																											ttcttttttgttttttttttt	0.418													2	4	---	---	---	---					
CTD-2336H13.2	0	broad.mit.edu	37	16	76936444	76936445	+	RNA	INS	-	-	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr16:76936444_76936445insA	ENST00000567777.1	+	0	138																											acttcatttacaaaaaaacagg	0.361													2	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7579582	7579583	+	Frame_Shift_Ins	INS	-	-	A	rs121912661		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:7579582_7579583insA	ENST00000420246.2	-	4	236_237	c.104_105insT	c.(103-105)tccfs	p.S35fs	TP53_ENST00000445888.2_Frame_Shift_Ins_p.S35fs|TP53_ENST00000359597.4_Frame_Shift_Ins_p.S35fs|TP53_ENST00000413465.2_Frame_Shift_Ins_p.S35fs|TP53_ENST00000269305.4_Frame_Shift_Ins_p.S35fs|TP53_ENST00000455263.2_Frame_Shift_Ins_p.S35fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	35	Interaction with HRMT1L2.|Transcription activation (acidic).		L -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.L35fs*8(4)|p.L35F(3)|p.?(1)|p.S33fs*23(1)|p.P13fs*18(1)|p.S33fs*6(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTTGGGACGGCAAGGGGGACTG	0.599		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			102	340	---	---	---	---					
CTC-501O10.1	0	broad.mit.edu	37	17	41777035	41777036	+	RNA	INS	-	-	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:41777035_41777036insG	ENST00000593169.1	+	0	93																											TGGGAGGGGATGGGGGGGTGAC	0.475													2	4	---	---	---	---					
RP11-893F2.5	0	broad.mit.edu	37	17	48290557	48290558	+	RNA	INS	-	-	C	rs146824499	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:48290557_48290558insC	ENST00000509943.1	+	0	399				RP11-893F2.15_ENST00000577175.1_RNA																							TTGCTGGGGCTTCCCCCCTGgc	0.554													4	9	---	---	---	---					
LINC01482	101928104	broad.mit.edu	37	17	66652728	66652728	+	RNA	DEL	G	G	-	rs148607395	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr17:66652728delG	ENST00000585484.1	+	0	129																											TAACCGGAATGGGTACCTCAA	0.403													2	4	---	---	---	---					
RP11-746B8.1	0	broad.mit.edu	37	18	30444122	30444122	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr18:30444122delT	ENST00000580366.1	+	0	27																											TCtggtatggtttgaatgtgt	0.443													2	4	---	---	---	---					
RP11-636O21.1	0	broad.mit.edu	37	18	37481016	37481016	+	RNA	DEL	T	T	-	rs151037405		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr18:37481016delT	ENST00000585822.1	-	0	218																											gcagagagtatttaaacatat	0.388													5	1	---	---	---	---					
RP11-325K19.1	0	broad.mit.edu	37	18	58554076	58554077	+	RNA	DEL	GT	GT	-	rs72201904		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr18:58554076_58554077delGT	ENST00000591869.1	-	0	38																											TGCTTTTGGGgtgtgtgtgtgt	0.455													3	3	---	---	---	---					
LOC284294	284294	broad.mit.edu	37	18	61805081	61805082	+	RNA	INS	-	-	ACAC	rs34096602	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr18:61805081_61805082insACAC	ENST00000589376.1	+	0	200				LINC00305_ENST00000323355.3_lincRNA	NR_033881.1																						Tacacacacatacacacacaca	0.327													3	4	---	---	---	---					
LINC01538	400654	broad.mit.edu	37	18	61891532	61891532	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr18:61891532delT	ENST00000588074.1	-	0	443				RP11-146N18.1_ENST00000589376.1_lincRNA	NR_033983.1																						catgtggtccttttttttccc	0.348													2	4	---	---	---	---					
RAVER1	125950	broad.mit.edu	37	19	10433827	10433828	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr19:10433827_10433828insC	ENST00000293677.6	-	5	1203_1204	c.1122_1123insG	c.(1120-1125)ggagcafs	p.A375fs		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	358	Interaction with PTBP1 (By similarity).					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			TTACCCTGCTTCCCCCCCGCAC	0.668													3	6	---	---	---	---					
LOC727993	727993	broad.mit.edu	37	20	1945066	1945066	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:1945066delT	ENST00000446562.1	+	0	476																											gttttggctcttttttttttg	0.403													3	6	---	---	---	---					
RP11-103J8.1	0	broad.mit.edu	37	20	10948588	10948588	+	RNA	DEL	C	C	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:10948588delC	ENST00000605292.1	+	0	439																											ggaaaaatgaccatttgccag	0.403													2	4	---	---	---	---					
RP4-734C18.1	0	broad.mit.edu	37	20	11251336	11251337	+	RNA	INS	-	-	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:11251336_11251337insA	ENST00000444792.1	-	0	432																											GCTAGaaaaacaaaaaacaaaa	0.426													2	4	---	---	---	---					
DLGAP4-AS1	101926987	broad.mit.edu	37	20	35190198	35190198	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr20:35190198delT	ENST00000439595.1	-	0	467				RP5-977B1.7_ENST00000425233.1_RNA|RP5-977B1.11_ENST00000561134.1_RNA																							gccactgtgctccagcctaag	0.458													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11036712	11036713	+	RNA	INS	-	-	AA	rs150393967		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr21:11036712_11036713insAA	ENST00000470054.1	-	0	1476									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTGACTTTAACAAAAAAATAGC	0.337													5	5	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11040447	11040447	+	RNA	DEL	A	A	-	rs145874834		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr21:11040447delA	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGGTAAGGATAAAAGAAAACT	0.343													4	7	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11063160	11063161	+	RNA	INS	-	-	A	rs147852817		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr21:11063160_11063161insA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		aaacgctatccaaaaaatgcag	0.282													5	9	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11094409	11094409	+	RNA	DEL	C	C	-	rs61674188		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr21:11094409delC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCTTAGCATGCAAAAATTATT	0.274													7	2	---	---	---	---					
AP000233.4	0	broad.mit.edu	37	21	26611867	26611867	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr21:26611867delT	ENST00000409758.1	-	0	89																											aacaatttcatttacaatagc	0.318													2	4	---	---	---	---					
AF096876.1	0	broad.mit.edu	37	21	31466644	31466644	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr21:31466644delT	ENST00000565564.1	+	0	275																											TGTTGCCCTATTCTTCAGCAT	0.373													2	4	---	---	---	---					
LOC101928233	101928233	broad.mit.edu	37	21	44030057	44030060	+	RNA	DEL	CGCA	CGCA	-	rs67305845		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr21:44030057_44030060delCGCA	ENST00000419628.1	-	0	206																											gccatgtgaccgcacccaaccaca	0.529													3	4	---	---	---	---					
CRYBB2P1	1416	broad.mit.edu	37	22	25868170	25868171	+	RNA	INS	-	-	G			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr22:25868170_25868171insG	ENST00000354451.2	+	0	366																											CAAGGCTGGCagggggtaaggg	0.550													2	4	---	---	---	---					
LARGE	9215	broad.mit.edu	37	22	33593904	33593905	+	RNA	DEL	AT	AT	-	rs72565599		TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr22:33593904_33593905delAT	ENST00000421232.1	-	0	150																											ataaacagacatatggatcaat	0.312													5	2	---	---	---	---					
ISX-AS1	101926957	broad.mit.edu	37	22	35369625	35369625	+	RNA	DEL	T	T	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chr22:35369625delT	ENST00000448318.4	-	0	1184																											GAAGTCCCACTAACCACATCT	0.428													2	4	---	---	---	---					
PTCHD1-AS	100873065	broad.mit.edu	37	X	22444900	22444903	+	RNA	DEL	GTGT	GTGT	-			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:22444900_22444903delGTGT	ENST00000455399.1	-	0	312																											TGTATCACGGGTGTGTGTGTGTGT	0.368													2	4	---	---	---	---					
RP11-268G12.1	0	broad.mit.edu	37	X	27318676	27318677	+	RNA	INS	-	-	A	rs111930568	by1000genomes	TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:27318676_27318677insA	ENST00000422048.1	-	0	232																											atgaaggtgaggaaaaaaccat	0.421													2	4	---	---	---	---					
FRMPD3-AS1	100874122	broad.mit.edu	37	X	106761782	106761783	+	RNA	INS	-	-	A			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:106761782_106761783insA	ENST00000415252.1	-	0	107																											aaggctattataaaaaaaaatg	0.356													2	4	---	---	---	---					
EMD	2010	broad.mit.edu	37	X	153608114	153608115	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z043-01A-01W-0746-08	TCGA-17-Z043-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	577f7267-c568-4002-a153-26c09d1eca97	fb9321cb-70ad-4dd6-9f9e-e4e2d45404dd	g.chrX:153608114_153608115insC	ENST00000369842.4	+	2	435_436	c.147_148insC	c.(145-150)tcccccfs	p.SP49fs	EMD_ENST00000369835.3_Intron|EMD_ENST00000492448.1_3'UTR	NM_000117.2	NP_000108.1	P50402	EMD_HUMAN	emerin	49	Interaction with F-actin (Probable).				cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding			lung(5)	5	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGCGGCTCTCGCCCCCCAGCTC	0.678													2	4	---	---	---	---