Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NLRP4	147945	broad.mit.edu	37	19	56382251	56382251	+	Missense_Mutation	SNP	C	C	G	rs144714657	by1000genomes	TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr19:56382251C>G	ENST00000301295.6	+	7	2835	c.2413C>G	c.(2413-2415)Cgt>Ggt	p.R805G	NLRP4_ENST00000346986.5_Missense_Mutation_p.R749G|NLRP4_ENST00000587891.1_Missense_Mutation_p.R730G	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	805							ATP binding	p.R805G(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AATGCTTCTGCGTAACAAGAG	0.522000													25	39					0	0	0.667858	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	NBPF10_ENST00000369338.1_Silent_p.L113L|NBPF10_ENST00000369339.2_Silent_p.L113L|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													3	75					0	0	0.150653	0	0
NCOA1	8648	broad.mit.edu	37	2	24930566	24930566	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr2:24930566T>G	ENST00000405141.1	+	14	2938	c.2227T>G	c.(2227-2229)Tca>Gca	p.S743A	NCOA1_ENST00000348332.3_Missense_Mutation_p.S743A|NCOA1_ENST00000406961.1_Missense_Mutation_p.S743A|NCOA1_ENST00000407230.1_Missense_Mutation_p.S592A|NCOA1_ENST00000395856.3_Missense_Mutation_p.S743A|NCOA1_ENST00000538539.1_Missense_Mutation_p.S743A|NCOA1_ENST00000288599.5_Missense_Mutation_p.S743A			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	743								p.S743A(2)	PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAAAAAAGAATCAAAAGACCA	0.383000			T	PAX3	alveolar rhadomyosarcoma								24	34					0	0	0.624587	0	0
TECRL	253017	broad.mit.edu	37	4	65146797	65146797	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr4:65146797G>T	ENST00000381210.3	-	11	1036	c.926C>A	c.(925-927)tCa>tAa	p.S309*	TECRL_ENST00000507440.1_Nonsense_Mutation_p.S309*	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	309					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors	p.S309*(1)		endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						ACTAATCCATGATCCAATCTG	0.284000													5	25					3.59834e-05	3.77825e-05	0.217242	1	0
C1QTNF7	114905	broad.mit.edu	37	4	15444073	15444073	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr4:15444073G>C	ENST00000295297.4	+	3	800	c.541G>C	c.(541-543)Gag>Cag	p.E181Q	C1QTNF7_ENST00000444304.2_Missense_Mutation_p.E174Q|C1QTNF7_ENST00000429690.1_Missense_Mutation_p.E174Q	NM_001135170.1	NP_001128642.1	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	174	C1q.					collagen		p.E174Q(1)|p.E174K(1)		endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	16						CCTCTTCAACGAGGGAGAGCA	0.443000													7	269					0	0	0.278610	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730641	140730641	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr5:140730641G>A	ENST00000523390.1	+	1	814	c.814G>A	c.(814-816)Gca>Aca	p.A272T	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1												p.A272T(1)		central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCATTAATGCAGAGATCAC	0.498000													24	89					0	0	0.654019	0	0
ITGAM	3684	broad.mit.edu	37	16	31282351	31282351	+	Silent	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr16:31282351G>T	ENST00000544665.3	+	6	575	c.504G>T	c.(502-504)cgG>cgT	p.R168R	ITGAM_ENST00000287497.8_Silent_p.R168R	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	168	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity	p.R168L(1)		endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						ACTTTCGGCGGATGAAGGAGT	0.507000													49	132					2.55665e-31	3.15821e-31	0.870114	1	0
DDX39B	7919	broad.mit.edu	37	6	31508296	31508296	+	Missense_Mutation	SNP	T	T	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr6:31508296T>G	ENST00000417556.2	-	2	644	c.14A>C	c.(13-15)gAt>gCt	p.D5A	DDX39B_ENST00000376177.2_Missense_Mutation_p.D5A|DDX39B_ENST00000449074.2_Missense_Mutation_p.D5A|DDX39B_ENST00000415382.2_Start_Codon_SNP_p.M1L|DDX39B_ENST00000453105.2_Start_Codon_SNP_p.M1L|DDX39B_ENST00000396172.1_Missense_Mutation_p.D5A|DDX39B_ENST00000458640.1_Missense_Mutation_p.D5A|ATP6V1G2-DDX39B_ENST00000376185.1_3'UTR			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	5					intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding	p.D5A(1)		NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						ATTGTCCACATCGTTCTCTGC	0.552000													16	66					0	0	0.557998	0	0
MMP12	4321	broad.mit.edu	37	11	102743681	102743681	+	RNA	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr11:102743681G>A	ENST00000532855.1	-	0	360							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.H88H(1)		autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	ATCGAGGTGCGTGCATCATCT	0.483000													6	19					0	0	0.217242	0	0
KANK4	163782	broad.mit.edu	37	1	62737210	62737210	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr1:62737210C>A	ENST00000371153.4	-	4	2330	c.1952G>T	c.(1951-1953)gGc>gTc	p.G651V	KANK4_ENST00000354381.3_Missense_Mutation_p.G23V|KANK4_ENST00000371150.1_Missense_Mutation_p.G7V	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	651								p.G651V(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						TGCACGGAAGCCATAGTCTTT	0.468000													5	154					2.0095e-06	2.15303e-06	0.248553	1	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	55					0	0	0.115264	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151142342	151142342	+	Missense_Mutation	SNP	C	C	T	rs140780640	byFrequency	TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr6:151142342C>T	ENST00000367328.1	+	14	1732	c.1420C>T	c.(1420-1422)Cgg>Tgg	p.R474W	PLEKHG1_ENST00000358517.2_Missense_Mutation_p.R474W	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	474					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity	p.R474W(1)		breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		ACCTTCCTCACGGTCACATAA	0.333000													14	41					0	0	0.457914	0	0
FDFT1	2222	broad.mit.edu	37	8	11683576	11683576	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr8:11683576G>A	ENST00000220584.4	+	5	776	c.554G>A	c.(553-555)cGt>cAt	p.R185H	FDFT1_ENST00000446331.2_Intron|FDFT1_ENST00000525900.1_Missense_Mutation_p.R178H|FDFT1_ENST00000525777.1_Missense_Mutation_p.R100H|FDFT1_ENST00000443614.2_Missense_Mutation_p.R142H|FDFT1_ENST00000538689.1_Missense_Mutation_p.R74H|FDFT1_ENST00000528643.1_Missense_Mutation_p.R100H|FDFT1_ENST00000530664.1_Missense_Mutation_p.R121H|FDFT1_ENST00000528812.1_Missense_Mutation_p.R121H	NM_004462.3	NP_004453.3	P37268	FDFT_HUMAN	farnesyl-diphosphate farnesyltransferase 1	185					cholesterol biosynthetic process|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	farnesyl-diphosphate farnesyltransferase activity|oxidoreductase activity|protein binding|squalene synthase activity	p.R185H(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)	12	all_epithelial(15;0.234)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.18)		GGCCTTTCCCGTCTTTTCTCA	0.428000													20	85					0	0	0.624587	0	0
TP53	7157	broad.mit.edu	37	17	7577085	7577085	+	Nonsense_Mutation	SNP	C	C	A	rs112431538		TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr17:7577085C>A	ENST00000420246.2	-	8	985	c.853G>T	c.(853-855)Gag>Tag	p.E285*	TP53_ENST00000455263.2_Nonsense_Mutation_p.E285*|TP53_ENST00000445888.2_Nonsense_Mutation_p.E285*|TP53_ENST00000359597.4_Nonsense_Mutation_p.E285*|TP53_ENST00000413465.2_Intron|TP53_ENST00000269305.4_Nonsense_Mutation_p.E285*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	285	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(111)|p.E285*(24)|p.0?(8)|p.E285Q(4)|p.?(2)|p.R283fs*16(2)|p.C275fs*20(1)|p.R282_E287delRRTEEE(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.T284_G293del10(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.G279fs*59(1)|p.R283fs*56(1)|p.E285fs*20(1)|p.E285fs*13(1)|p.R283fs*59(1)|p.V272_K292del21(1)|p.E285_N288delEEEN(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			33	22					2.08457e-15	2.35354e-15	0.750413	1	0
BTNL2	56244	broad.mit.edu	37	6	32362585	32362585	+	Silent	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr6:32362585G>A	ENST00000454136.3	-	6	1300	c.1296C>T	c.(1294-1296)gaC>gaT	p.D432D	BTNL2_ENST00000374993.1_Silent_p.D432D|BTNL2_ENST00000414363.1_Silent_p.D222D|BTNL2_ENST00000374995.3_Silent_p.D338D|BTNL2_ENST00000540315.1_Silent_p.D222D|BTNL2_ENST00000544175.1_Silent_p.D155D|BTNL2_ENST00000429232.2_3'UTR			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	432						integral to membrane		p.D432D(1)		central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						AACAAGTGACGTCCACAGCGG	0.498000													29	135					0	0	0.750413	0	0
TMEM132A	54972	broad.mit.edu	37	11	60695271	60695271	+	Silent	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr11:60695271C>T	ENST00000005286.4	+	3	627	c.474C>T	c.(472-474)ccC>ccT	p.P158P	TMEM132A_ENST00000453848.2_Silent_p.P158P	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	158						endoplasmic reticulum membrane|Golgi membrane|integral to membrane		p.P158P(2)		breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						GCAGCCTGCCCTGTGCCCGGC	0.657000													10	44					0	0	0.387290	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102296140	102296140	+	RNA	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr15:102296140C>T	ENST00000561463.1	+	0	4186																											GTCCAACCTGCACTCGCGTGG	0.602000													4	3					0	0	0.150653	0	0
CFL2	1073	broad.mit.edu	37	14	35182544	35182544	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr14:35182544G>A	ENST00000341223.3	-	2	378	c.227C>T	c.(226-228)cCt>cTt	p.P76L	CFL2_ENST00000298159.6_Missense_Mutation_p.P76L|CFL2_ENST00000555765.1_Missense_Mutation_p.P59L|CFL2_ENST00000556161.1_Missense_Mutation_p.P59L	NM_001243645.1|NM_021914.7	NP_001230574.1|NP_068733.1	Q9Y281	COF2_HUMAN	cofilin 2 (muscle)	76	ADF-H.					cytoplasm|cytoskeleton|nuclear matrix	actin binding	p.P76L(1)		breast(3)|endometrium(2)|lung(3)	8	Breast(36;0.0361)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;6.07e-06)|Lung(238;2.23e-05)|Epithelial(34;0.0387)|all cancers(34;0.0814)	GBM - Glioblastoma multiforme(112;0.0424)		ATCATTCAGAGGTAGCAACTT	0.383000													26	88					0	0	0.693898	0	0
HIST1H3F	8968	broad.mit.edu	37	6	26250719	26250719	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr6:26250719G>T	ENST00000446824.2	-	1	116	c.115C>A	c.(115-117)Ccc>Acc	p.P39T		NM_021018.2	NP_066298.1	P68431	H31_HUMAN	histone cluster 1, H3f	39					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding	p.P39T(1)		lung(6)|urinary_tract(1)	7						TAGCGGTGGGGCTTCTTCACG	0.612000													27	89					6.55177e-30	7.99926e-30	0.717897	1	0
MYO1B	4430	broad.mit.edu	37	2	192225432	192225432	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr2:192225432C>G	ENST00000392318.3	+	8	885	c.638C>G	c.(637-639)tCt>tGt	p.S213C	MYO1B_ENST00000339514.4_Missense_Mutation_p.S213C|MYO1B_ENST00000392316.1_Missense_Mutation_p.S213C|MYO1B_ENST00000304164.4_Missense_Mutation_p.S213C	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	213	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity	p.S213C(2)		NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			CAGCTGCTCTCTGGTGCCTCT	0.413000													90	112					0	0	0.870114	0	0
GLYATL1	92292	broad.mit.edu	37	11	58723213	58723213	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr11:58723213G>T	ENST00000300079.5	+	7	765	c.715G>T	c.(715-717)Gcc>Tcc	p.A239S	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Missense_Mutation_p.A208S	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	208						mitochondrion	glycine N-acyltransferase activity	p.A239S(1)|p.A208S(1)		NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	CCTGCCAGCAGCCTGTATGCT	0.522000													8	28					3.86212e-05	4.01507e-05	0.361761	1	0
CSNK1A1P1	161635	broad.mit.edu	37	15	37109938	37109938	+	RNA	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr15:37109938G>T	ENST00000430593.3	-	0	722					NR_027320.1																						CTGGTTTAATGGCTCTGTGTA	0.378000													18	23					3.8784e-16	4.42644e-16	0.608945	1	0
RP11-407N17.3	0	broad.mit.edu	37	14	39716224	39716224	+	Missense_Mutation	SNP	A	A	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr14:39716224A>T	ENST00000553728.1	+	4	659	c.446A>T	c.(445-447)gAt>gTt	p.D149V	MIA2_ENST00000280082.3_Missense_Mutation_p.D149V|MIA2_ENST00000556784.1_Missense_Mutation_p.D148V														p.D149V(1)									GAAGATAAAGATGAAAAATCT	0.299000													9	34					0	0	0.335167	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185954	127185954	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chrX:127185954G>T	ENST00000371124.3	-	1	428	c.232C>A	c.(232-234)Ctg>Atg	p.L78M		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	78						cytoplasm|cytoskeleton		p.L78M(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						CCTGTTACCAGTCCACGCTCA	0.493000													64	210					3.37043e-27	4.02153e-27	0.870114	1	0
FGD5	152273	broad.mit.edu	37	3	14862467	14862467	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr3:14862467C>A	ENST00000285046.5	+	1	1999	c.1889C>A	c.(1888-1890)aCa>aAa	p.T630K	FGD5_ENST00000543601.1_Missense_Mutation_p.T389K	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	630					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding	p.T630K(1)|p.T389K(1)		NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						AAGCCCATCACAAAGAGCTCT	0.547000													9	36					0.00829132	0.00853518	0.361761	1	0
TUBB8P7	197331	broad.mit.edu	37	16	90161578	90161578	+	RNA	SNP	G	G	A	rs13337896	by1000genomes	TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr16:90161578G>A	ENST00000567960.1	+	0	314				TUBB8P7_ENST00000564451.1_RNA														p.R105H(3)									GCCAAGGGACGCTACACCGAA	0.587000													6	21					0	0	0.217242	0	0
SPAG4	6676	broad.mit.edu	37	20	34208665	34208665	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr20:34208665G>C	ENST00000374273.3	+	11	1249	c.1137G>C	c.(1135-1137)gaG>gaC	p.E379D		NM_003116.1	NP_003107.1	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	379	SUN.				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity	p.E379D(1)		NS(1)|cervix(5)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			TCGATGTTGAGAAATCGGAGA	0.507000													20	279					0	0	0.608945	0	0
CSMD1	64478	broad.mit.edu	37	8	3226892	3226892	+	Splice_Site	SNP	G	G	C			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr8:3226892G>C	ENST00000520002.1	-	20	3341	c.2785_splice	c.e20-1	p.A929_splice	CSMD1_ENST00000537824.1_Splice_Site_p.A928_splice|CSMD1_ENST00000602723.1_Splice_Site_p.A929_splice|CSMD1_ENST00000400186.3_Splice_Site_p.A929_splice|CSMD1_ENST00000602557.1_Splice_Site_p.A929_splice|CSMD1_ENST00000542608.1_Splice_Site_p.A928_splice|CSMD1_ENST00000539096.1_Splice_Site_p.A928_splice			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	929	Sushi 5.					integral to membrane		p.A928G(1)|p.A657G(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCCACATAGAGCTTAAAATAA	0.388000													3	19					0	0	0.115264	0	0
PTDSS1	9791	broad.mit.edu	37	8	97321848	97321848	+	Silent	SNP	T	T	C			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr8:97321848T>C	ENST00000517309.1	+	9	1397	c.1071T>C	c.(1069-1071)ttT>ttC	p.F357F	PTDSS1_ENST00000455950.2_Silent_p.F211F|PTDSS1_ENST00000522072.1_Silent_p.F154F	NM_014754.1	NP_055569.1	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	357					phosphatidylserine biosynthetic process	integral to membrane	transferase activity	p.F357F(1)		endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|stomach(1)	29	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	GCTGGGTGTTTGGGTGAGTAA	0.408000													18	38					0	0	0.639603	0	0
TOP3B	8940	broad.mit.edu	37	22	22323138	22323138	+	Silent	SNP	A	A	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr22:22323138A>G	ENST00000398793.2	-	7	1025	c.591T>C	c.(589-591)acT>acC	p.T197T	TOP3B_ENST00000357179.5_Silent_p.T197T|TOP3B_ENST00000413067.2_5'UTR	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	197					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding	p.T197T(2)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		GGAAATATTTAGTCTGAAACC	0.488000													3	99					0	0	0.150653	0	0
CCDC178	374864	broad.mit.edu	37	18	30791980	30791980	+	Silent	SNP	T	T	A	rs61749300		TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr18:30791980T>A	ENST00000383096.3	-	20	2300	c.2118A>T	c.(2116-2118)gcA>gcT	p.A706A	CCDC178_ENST00000583930.1_Silent_p.A706A|CCDC178_ENST00000406524.2_Silent_p.A706A|CCDC178_ENST00000403303.1_Silent_p.A706A|CCDC178_ENST00000579947.1_Silent_p.A706A|CCDC178_ENST00000402325.1_Silent_p.A706A|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000300227.8_Silent_p.A668A					coiled-coil domain containing 178									p.A668A(1)|p.A706A(1)									ACACAGTTTGTGCATGTTCCC	0.323000													7	27					0	0	0.278610	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507534	74507534	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr1:74507534A>G	ENST00000354431.4	-	7	1272	c.1081T>C	c.(1081-1083)Tca>Cca	p.S361P	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.S361P	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	361				S -> G (in Ref. 4; AAH62795).				p.S361P(1)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						AATGAACCTGAAGTGTATATG	0.353000													28	68					0	0	0.681144	0	0
TTC14	151613	broad.mit.edu	37	3	180320181	180320181	+	Silent	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr3:180320181C>T	ENST00000412756.2	+	1	201	c.132C>T	c.(130-132)ggC>ggT	p.G44G	TTC14_ENST00000382584.4_Silent_p.G44G|TTC14_ENST00000296015.4_Silent_p.G44G	NM_001042601.2	NP_001036066.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	44							RNA binding	p.G44G(1)		endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CAGCCCGGGGCCCGCCGCCCC	0.672000													5	5					0	0	0.217242	0	0
COL17A1	1308	broad.mit.edu	37	10	105800830	105800830	+	Silent	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr10:105800830G>A	ENST00000353479.5	-	39	2984	c.2694C>T	c.(2692-2694)tcC>tcT	p.S898S	COL17A1_ENST00000369733.3_Silent_p.S898S	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	898	Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding	p.S898S(1)		NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TACCTGAGTTGGACAGGAACG	0.577000													6	46					0	0	0.278610	0	0
GYS1	2997	broad.mit.edu	37	19	49494725	49494725	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr19:49494725G>T	ENST00000323798.3	-	2	330	c.134C>A	c.(133-135)aCg>aAg	p.T45K	GYS1_ENST00000263276.6_Missense_Mutation_p.T45K|GYS1_ENST00000541188.1_Intron|GYS1_ENST00000544287.1_Intron|GYS1_ENST00000540532.1_Intron|GYS1_ENST00000457974.1_5'UTR	NM_002103.4	NP_002094.2	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle)	45					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding	p.T45K(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		CTGCAGCACCGTGTAGATGCC	0.672000													14	108					2.32078e-09	2.53836e-09	0.479597	1	0
PCDH18	54510	broad.mit.edu	37	4	138453153	138453153	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr4:138453153C>G	ENST00000344876.4	-	1	476	c.90G>C	c.(88-90)ttG>ttC	p.L30F	PCDH18_ENST00000412923.2_Missense_Mutation_p.L30F|PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000507846.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	30	Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.L30F(1)		NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TCCTGTATTTCAAATTCTTGC	0.378000													3	117					0	0	0.150653	0	0
RPL6	6128	broad.mit.edu	37	12	112843710	112843710	+	Missense_Mutation	SNP	T	T	G	rs148929822	byFrequency	TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr12:112843710T>G	ENST00000424576.2	-	6	846	c.661A>C	c.(661-663)Aag>Cag	p.K221Q	RPL6_ENST00000202773.9_Missense_Mutation_p.K221Q	NM_001024662.1	NP_001019833.1	Q02878	RL6_HUMAN	ribosomal protein L6	221					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome	p.K221Q(1)		cervix(1)|large_intestine(6)|lung(3)	10						TTCCGCAGCTTCTTCTTCTTG	0.423000													15	79					0	0	0.520397	0	0
IRX6	79190	broad.mit.edu	37	16	55360423	55360423	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr16:55360423C>T	ENST00000290552.7	+	2	1553	c.221C>T	c.(220-222)cCc>cTc	p.P74L	RP11-26L20.3_ENST00000558730.2_RNA|IRX6_ENST00000558315.1_3'UTR	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	74						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.P74H(1)|p.P74L(1)		breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						TATGGAGCACCCTATGCGGCC	0.672000													5	6					0	0	0.248553	0	0
ITGA2	3673	broad.mit.edu	37	5	52360756	52360756	+	Silent	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr5:52360756G>A	ENST00000296585.5	+	14	1760	c.1617G>A	c.(1615-1617)caG>caA	p.Q539Q		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	539					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity	p.Q539Q(2)		breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TTTTGGGTCAGCACCAATTTC	0.428000													3	50					0	0	0.150653	0	0
SSTR1	6751	broad.mit.edu	37	14	38679102	38679102	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr14:38679102C>T	ENST00000267377.2	+	3	1125	c.508C>T	c.(508-510)Cgg>Tgg	p.R170W		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	170					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity	p.R170W(1)		breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	CCGCTACCGCCGGCCCACCGT	0.637000													5	39					0	0	0.217242	0	0
WBSCR17	64409	broad.mit.edu	37	7	71175812	71175812	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr7:71175812G>A	ENST00000333538.5	+	10	2201	c.1567G>A	c.(1567-1569)Gac>Aac	p.D523N	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	523	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.D523N(1)		NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				ACTCCTCCCTGACACCCGCTG	0.612000													15	61					0	0	0.479597	0	0
BRINP3	339479	broad.mit.edu	37	1	190067206	190067206	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr1:190067206G>A	ENST00000367462.3	-	8	2474	c.2243C>T	c.(2242-2244)gCg>gTg	p.A748V	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.A646V	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		748						extracellular region		p.A748V(1)		NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GGCATTAAACGCCTGCAGAGC	0.428000													6	158					0	0	0.248553	0	0
MMP27	64066	broad.mit.edu	37	11	102565768	102565768	+	Missense_Mutation	SNP	G	G	C			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr11:102565768G>C	ENST00000260229.4	-	7	1054	c.963C>G	c.(961-963)ttC>ttG	p.F321L		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	321	Hemopexin-like 1.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.F321L(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		GAGATGGCCAGAATGAAGCAA	0.423000													6	74					0	0	0.278610	0	0
OR4D9	390199	broad.mit.edu	37	11	59283060	59283060	+	Silent	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr11:59283060G>A	ENST00000329328.3	+	1	675	c.675G>A	c.(673-675)ctG>ctA	p.L225L		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L225L(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						TGATGATGCTGAGGTCTCACA	0.488000													34	140					0	0	0.760397	0	0
RGS12	6002	broad.mit.edu	37	4	3344679	3344679	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr4:3344679C>T	ENST00000336727.3	+	3	2801	c.1897C>T	c.(1897-1899)Cgg>Tgg	p.R633W	RGS12_ENST00000306648.7_Missense_Mutation_p.R31W|RGS12_ENST00000543385.1_Missense_Mutation_p.R633W|RGS12_ENST00000382788.3_Missense_Mutation_p.R633W|RGS12_ENST00000344733.5_Missense_Mutation_p.R633W	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	633						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity	p.R633W(1)		autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AAAATTTGGGCGGGGAACTGG	0.448000													10	57					0	0	0.411799	0	0
SALL1	6299	broad.mit.edu	37	16	51173914	51173914	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr16:51173914C>T	ENST00000440970.1	-	2	2359	c.1928G>A	c.(1927-1929)gGc>gAc	p.G643D	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.G740D	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	740					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.G740D(1)		NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GAAAGCCCGGCCACAGATCTT	0.552000													6	33					0	0	0.217242	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51630513	51630513	+	Silent	SNP	T	T	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr19:51630513T>A	ENST00000440804.3	+	4	1042	c.975T>A	c.(973-975)ccT>ccA	p.P325P	SIGLEC9_ENST00000250360.3_Silent_p.P325P	NM_001198558.1	NP_001185487.1	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9	325	Ig-like C2-type 2.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding	p.P325P(1)		NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(3)|lung(25)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	45		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CTCAGAACCCTCTCGGCTCTC	0.612000													6	14					0	0	0.217242	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr7:55259515T>G	ENST00000275493.2	+	21	2750	c.2573T>G	c.(2572-2574)cTg>cGg	p.L858R	EGFR_ENST00000455089.1_Missense_Mutation_p.L813R|EGFR_ENST00000454757.2_Missense_Mutation_p.L805R|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	858	Protein kinase.		L -> M (found in a lung cancer sample).|L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(1489)|p.L858Q(1)|p.L858K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537000	L858R(NCIH1975_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			23	57					0	0	0.639603	0	0
NAP1L5	266812	broad.mit.edu	37	4	89618409	89618409	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr4:89618409C>T	ENST00000323061.5	-	1	977	c.497G>A	c.(496-498)gGg>gAg	p.G166E	HERC3_ENST00000543130.1_Intron|HERC3_ENST00000402738.1_Intron|HERC3_ENST00000264345.3_Intron	NM_153757.2	NP_715638.1	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	166					nucleosome assembly	nucleus	protein binding	p.G166E(1)		endometrium(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		ATGTTTGGCCCCCGCGGCAGC	0.612000													27	75					0	0	0.729181	0	0
TBC1D16	125058	broad.mit.edu	37	17	77915948	77915948	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr17:77915948C>T	ENST00000310924.2	-	11	2081	c.1966G>A	c.(1966-1968)Gtc>Atc	p.V656I	TBC1D16_ENST00000576768.1_Missense_Mutation_p.V281I|TBC1D16_ENST00000340848.7_Missense_Mutation_p.V294I	NM_001271844.1|NM_001271845.1|NM_019020.2	NP_001258773.1|NP_001258774.1|NP_061893.2	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	656						intracellular	Rab GTPase activator activity	p.V656I(1)		NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(3)	28	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			TGCTCGATGACGTCATCCCCG	0.612000													5	18					0	0	0.217242	0	0
ESPNP	284729	broad.mit.edu	37	1	17017751	17017751	+	RNA	SNP	C	C	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr1:17017751C>G	ENST00000492551.1	-	0	1976					NR_026567.1																						GGTCCCACCTCCAGGCGGGCA	0.662000													9	15					0	0	0.307466	0	0
RIOK2	55781	broad.mit.edu	37	5	96503628	96503628	+	Missense_Mutation	SNP	C	C	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr5:96503628C>G	ENST00000283109.3	-	8	1008	c.940G>C	c.(940-942)Gaa>Caa	p.E314Q	CTD-2215E18.1_ENST00000509481.1_Intron|RIOK2_ENST00000508447.1_Missense_Mutation_p.E314Q	NM_018343.2	NP_060813.2	Q9BVS4	RIOK2_HUMAN	RIO kinase 2	314	Protein kinase.						ATP binding|protein serine/threonine kinase activity	p.E314Q(2)		breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|urinary_tract(2)	23		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		TGAAGCAGTTCATCATCTGCC	0.408000													26	91					0	0	0.706142	0	0
ITGAM	3684	broad.mit.edu	37	16	31282350	31282350	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr16:31282350G>T	ENST00000544665.3	+	6	574	c.503G>T	c.(502-504)cGg>cTg	p.R168L	ITGAM_ENST00000287497.8_Missense_Mutation_p.R168L	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	168	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity	p.R168L(1)		endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						GACTTTCGGCGGATGAAGGAG	0.507000													50	133					1.67211e-32	2.09014e-32	0.870114	1	0
PIP4K2B	8396	broad.mit.edu	37	17	36935652	36935652	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr17:36935652C>T	ENST00000269554.3	-	5	1118	c.638G>A	c.(637-639)cGc>cAc	p.R213H	PIP4K2B_ENST00000311500.6_5'UTR	NM_003559.4	NP_003550.1	P78356	PI42B_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, beta	213	PIPK.				cell surface receptor linked signaling pathway	endoplasmic reticulum membrane|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|receptor signaling protein activity	p.R213H(1)		endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)	19						GTCATACTTGCGATGCACAGT	0.552000													4	139					0	0	0.217242	0	0
TENM2	57451	broad.mit.edu	37	5	167551958	167551958	+	Silent	SNP	C	C	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr5:167551958C>A	ENST00000519204.1	+	10	1867	c.1749C>A	c.(1747-1749)gtC>gtA	p.V583V	TENM2_ENST00000520394.1_Silent_p.V472V|TENM2_ENST00000403607.2_Silent_p.V537V|TENM2_ENST00000545108.1_Silent_p.V704V|TENM2_ENST00000518659.1_Silent_p.V704V|CTB-178M22.1_ENST00000517408.1_RNA					teneurin transmembrane protein 2									p.V704V(1)|p.V537V(1)|p.V583V(1)									TGGCGAGGGTCCAGTGCCCAG	0.617000													4	19					0.00909568	0.0092723	0.150653	1	0
DPPA4	55211	broad.mit.edu	37	3	109049557	109049557	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr3:109049557G>A	ENST00000335658.6	-	5	547	c.493C>T	c.(493-495)Cct>Tct	p.P165S	DPPA4_ENST00000478791.1_5'UTR	NM_018189.3	NP_060659.3	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	165						nucleus	protein binding	p.P165S(1)		central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(17)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25						ACTTCAGGAGGATGTGTCTCA	0.483000													36	58					0	0	0.796494	0	0
MYRF	745	broad.mit.edu	37	11	61539415	61539415	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr11:61539415A>G	ENST00000278836.5	+	7	1202	c.1106A>G	c.(1105-1107)tAc>tGc	p.Y369C	TMEM258_ENST00000535042.1_Intron|MYRF_ENST00000265460.5_Missense_Mutation_p.Y360C	NM_001127392.1	NP_001120864.1			myelin regulatory factor									p.Y360C(1)									GATGCTAACTACAAGGAGCTG	0.617000													15	58					0	0	0.520397	0	0
COL6A2	1292	broad.mit.edu	37	21	47532313	47532313	+	Missense_Mutation	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr21:47532313G>T	ENST00000300527.4	+	3	640	c.536G>T	c.(535-537)cGg>cTg	p.R179L	COL6A2_ENST00000310645.5_Missense_Mutation_p.R179L|COL6A2_ENST00000409416.1_Missense_Mutation_p.R179L|COL6A2_ENST00000397763.1_Missense_Mutation_p.R179L|COL6A2_ENST00000357838.4_Missense_Mutation_p.R179L	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	179	Nonhelical region.|VWFA 1.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging	p.R179L(3)		NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CAGGCCGAGCGGGCCCGCGAG	0.716000													14	10					1.3612e-06	1.47347e-06	0.479597	1	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	RNA	SNP	G	G	A	rs150520281	by1000genomes	TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr16:21817457G>A	ENST00000546471.1	-	0	1601																											CTTACATCCAGCTTGAGTAGT	0.259000													4	17					0	0	0.217242	0	0
RABEP1	9135	broad.mit.edu	37	17	5286437	5286437	+	Silent	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr17:5286437G>A	ENST00000262477.6	+	18	2732	c.2508G>A	c.(2506-2508)cgG>cgA	p.R836R	NUP88_ENST00000573169.1_Intron|RABEP1_ENST00000546142.2_Silent_p.R836R|RABEP1_ENST00000537505.1_Silent_p.R793R|RABEP1_ENST00000408982.2_Silent_p.R803R|RABEP1_ENST00000341923.6_Silent_p.R803R	NM_004703.4	NP_004694.2	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	836					apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity	p.R836R(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	8						AGCGGATCCGGCAAGCTGACT	0.473000													3	53					0	0	0.115264	0	0
XIRP2	129446	broad.mit.edu	37	2	168115032	168115032	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr2:168115032A>G	ENST00000409728.1	+	11	2164	c.2075A>G	c.(2074-2076)aAt>aGt	p.N692S	XIRP2_ENST00000295237.9_3'UTR|XIRP2_ENST00000409195.1_3'UTR|XIRP2_ENST00000409043.1_Missense_Mutation_p.N659S|XIRP2_ENST00000409756.2_Missense_Mutation_p.N659S|XIRP2_ENST00000409605.1_Missense_Mutation_p.N437S|XIRP2_ENST00000409273.1_3'UTR|XIRP2_ENST00000420519.1_Missense_Mutation_p.N692S	NM_001199143.1	NP_001186072.1	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding	p.N692S(1)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATGGATCTTAATGACAACAAT	0.373000													7	30					0	0	0.278610	0	0
SLC25A12	8604	broad.mit.edu	37	2	172644412	172644412	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr2:172644412G>A	ENST00000422440.2	-	16	1668	c.1631C>T	c.(1630-1632)aCa>aTa	p.T544I	SLC25A12_ENST00000392592.4_Missense_Mutation_p.T437I	NM_003705.4	NP_003696.2	O75746	CMC1_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 12	544					gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding	p.T544I(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|upper_aerodigestive_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	CTGCAGTCTTGTCTTGATGAC	0.493000													10	21					0	0	0.435327	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													3	44					0	0	0.217242	0	0
BAHCC1	57597	broad.mit.edu	37	17	79409981	79409981	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr17:79409981C>T	ENST00000307745.7	+	9	1606	c.1606C>T	c.(1606-1608)Cca>Tca	p.P536S															p.P536S(1)									GGCCGGCCCCCCAGGGGCACA	0.692000													20	12					0	0	0.624587	0	0
SPAG4	6676	broad.mit.edu	37	20	34207180	34207180	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr20:34207180G>A	ENST00000374273.3	+	9	969	c.857G>A	c.(856-858)tGg>tAg	p.W286*		NM_003116.1	NP_003107.1	Q9NPE6	SPAG4_HUMAN	sperm associated antigen 4	286	SUN.				spermatogenesis	cilium|flagellar axoneme|integral to membrane	structural molecule activity	p.W286*(1)		NS(1)|cervix(5)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.0127)			GCCTACTTCTGGAATCGCTTC	0.597000													27	203					0	0	0.750413	0	0
C5orf51	285636	broad.mit.edu	37	5	41904478	41904478	+	Silent	SNP	C	C	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr5:41904478C>G	ENST00000381647.2	+	1	28	c.9C>G	c.(7-9)gcC>gcG	p.A3A	C5orf51_ENST00000505931.2_Intron	NM_175921.4	NP_787117.3	A6NDU8	CE051_HUMAN	chromosome 5 open reading frame 51	3								p.A3A(1)		endometrium(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						CCATGGCGGCCGCAGTCTCTA	0.662000													10	10					0	0	0.435327	0	0
WDFY3	23001	broad.mit.edu	37	4	85781638	85781638	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr4:85781638C>T	ENST00000322366.6	-	4	514	c.107G>A	c.(106-108)tGc>tAc	p.C36Y	WDFY3_ENST00000295888.4_Missense_Mutation_p.C36Y			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	36						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding	p.C36Y(1)		breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GGGAGGATGGCACAACTCCGT	0.557000													16	47					0	0	0.539581	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92838013	92838013	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr7:92838013G>A	ENST00000394468.2	-	4	969	c.892C>T	c.(892-894)Cgc>Tgc	p.R298C	HEPACAM2_ENST00000440868.1_Missense_Mutation_p.R286C|HEPACAM2_ENST00000453812.2_Missense_Mutation_p.R321C|HEPACAM2_ENST00000341723.4_Missense_Mutation_p.R286C	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	298	Ig-like C2-type 2.					integral to membrane		p.R286C(1)|p.R298C(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						ACTTCTAAGCGAGGCCCATGC	0.448000													39	59					0	0	0.804634	0	0
XDH	7498	broad.mit.edu	37	2	31598368	31598368	+	Silent	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr2:31598368G>A	ENST00000379416.3	-	15	1528	c.1480C>T	c.(1480-1482)Ctg>Ttg	p.L494L		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	494					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity	p.L494L(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GGCAGATGCAGCTCCTCTGCC	0.627000													22	26					0	0	0.608945	0	0
MMP27	64066	broad.mit.edu	37	11	102565801	102565801	+	Silent	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr11:102565801G>A	ENST00000260229.4	-	7	1021	c.930C>T	c.(928-930)atC>atT	p.I310I		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	310	Hemopexin-like 1.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.I310I(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		CAACATCCGTGATATCATAAT	0.388000													7	92					0	0	0.248553	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21355464	21355464	+	Missense_Mutation	SNP	T	T	C			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr12:21355464T>C	ENST00000256958.2	+	10	1271	c.1175T>C	c.(1174-1176)tTa>tCa	p.L392S		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	392					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity	p.L392S(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	GGAATGTTTTTAGGAGGATAT	0.289000													18	30					0	0	0.557998	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													3	75					0	0	0.115264	0	0
PKD1L2	114780	broad.mit.edu	37	16	81151065	81151065	+	RNA	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr16:81151065G>T	ENST00000533478.1	-	0	4738				PKD1L2_ENST00000525539.1_RNA|PKD1L2_ENST00000534142.1_RNA	NM_001278425.1	NP_001265354.1	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						AGCTGGCCAGGATGATGGCCA	0.612000													41	50					1.00001e-27	1.2069e-27	0.847076	1	0
PPP6R3	55291	broad.mit.edu	37	11	68337296	68337296	+	Silent	SNP	T	T	C			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr11:68337296T>C	ENST00000393799.2	+	11	1476	c.1209T>C	c.(1207-1209)ccT>ccC	p.P403P	PPP6R3_ENST00000529710.1_Silent_p.P352P|PPP6R3_ENST00000534534.1_Silent_p.P171P|PPP6R3_ENST00000527403.2_Silent_p.P403P|PPP6R3_ENST00000265637.4_Silent_p.P403P|PPP6R3_ENST00000393800.2_Silent_p.P403P|PPP6R3_ENST00000265636.5_Silent_p.P352P|PPP6R3_ENST00000524904.1_Silent_p.P403P|PPP6R3_ENST00000393801.3_Silent_p.P403P|PPP6R3_ENST00000524845.1_Silent_p.P403P			Q5H9R7	PP6R3_HUMAN	protein phosphatase 6, regulatory subunit 3	403					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding	p.P352P(1)|p.P403P(1)		breast(2)|endometrium(6)|kidney(3)|large_intestine(10)|liver(2)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TTGCAAGTCCTTTTGAAAACA	0.333000													3	174					0	0	0.150653	0	0
MMP27	64066	broad.mit.edu	37	11	102565710	102565710	+	Silent	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr11:102565710G>A	ENST00000260229.4	-	7	1112	c.1021C>T	c.(1021-1023)Ctg>Ttg	p.L341L		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	341	Hemopexin-like 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.L341L(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		TTAAAAACCAGAATCTTATCT	0.428000													7	31					0	0	0.248553	0	0
CEP95	90799	broad.mit.edu	37	17	62504728	62504728	+	Missense_Mutation	SNP	A	A	G			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr17:62504728A>G	ENST00000556440.2	+	2	548	c.38A>G	c.(37-39)aAt>aGt	p.N13S	CEP95_ENST00000581056.1_Missense_Mutation_p.N13S|CEP95_ENST00000553412.1_5'UTR	NM_138363.1	NP_612372.1	Q96GE4	CEP95_HUMAN	centrosomal protein 95kDa	13						centrosome|spindle pole	protein binding	p.N13S(2)		endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)	13						ACCATTGCCAATAACCTTCTT	0.348000													22	48					0	0	0.624587	0	0
MKLN1	4289	broad.mit.edu	37	7	131113849	131113849	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr7:131113849C>T	ENST00000352689.6	+	9	945	c.905C>T	c.(904-906)gCg>gTg	p.A302V	MKLN1_ENST00000421797.2_Missense_Mutation_p.A210V	NM_013255.4	NP_037387.2	Q9UL63	MKLN1_HUMAN	muskelin 1, intracellular mediator containing kelch motifs	302					signal transduction	cytoplasm	protein binding	p.A302V(1)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	28	Melanoma(18;0.162)					GACTTCTGGGCGTACAGTGTG	0.388000													9	80					0	0	0.361761	0	0
MED13	9969	broad.mit.edu	37	17	60040305	60040305	+	Silent	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr17:60040305G>T	ENST00000397786.2	-	21	4948	c.4872C>A	c.(4870-4872)atC>atA	p.I1624I		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1624					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding	p.I1624I(1)		breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						CATCTGTGGGGATTCCCACTT	0.388000													41	156					5.44703e-19	6.35487e-19	0.847076	1	0
ATRX	546	broad.mit.edu	37	X	76875916	76875916	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chrX:76875916G>T	ENST00000373344.5	-	20	5433	c.5219C>A	c.(5218-5220)tCa>tAa	p.S1740*	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Nonsense_Mutation_p.S1702*	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1740	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.S1740*(2)|p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	CCTCCTCCTTGATCGTATAGA	0.333000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						8	43					1.12685e-05	1.19514e-05	0.307466	1	0
TP53BP2	7159	broad.mit.edu	37	1	223983555	223983555	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr1:223983555G>A	ENST00000391878.2	-	14	3067	c.2299C>T	c.(2299-2301)Cgc>Tgc	p.R767C	TP53BP2_ENST00000498843.1_5'UTR|TP53BP2_ENST00000391879.2_Missense_Mutation_p.R129C|TP53BP2_ENST00000343537.7_Missense_Mutation_p.R896C	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	890					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity	p.R896C(1)|p.R767C(1)		NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		TCAGGCGGGCGCATGCTCACC	0.537000													4	80					0	0	0.184627	0	0
CSMD3	114788	broad.mit.edu	37	8	113564858	113564858	+	Missense_Mutation	SNP	C	C	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr8:113564858C>A	ENST00000297405.5	-	26	4570	c.4326G>T	c.(4324-4326)atG>atT	p.M1442I	CSMD3_ENST00000343508.3_Missense_Mutation_p.M1402I|CSMD3_ENST00000455883.2_Missense_Mutation_p.M1338I|CSMD3_ENST00000352409.3_Missense_Mutation_p.M1442I	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1442	CUB 8.					integral to membrane|plasma membrane		p.M1442I(1)|p.M1402I(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CAATCATCCACATGCAACGCA	0.378000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			28	42					7.01153e-11	7.74959e-11	0.717897	1	0
PAK1IP1	55003	broad.mit.edu	37	6	10702848	10702848	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr6:10702848C>A	ENST00000379568.3	+	4	710	c.419C>A	c.(418-420)tCg>tAg	p.S140*		NM_017906.2	NP_060376.2	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1	140					negative regulation of signal transduction	nucleolus|plasma membrane		p.S140Y(1)		kidney(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	12	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)				TTGGCCCTGTCGGTTGGTACA	0.408000													30	112					1.61788e-16	1.86678e-16	0.760397	1	0
TRUB2	26995	broad.mit.edu	37	9	131071839	131071839	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr9:131071839G>A	ENST00000372890.4	-	8	1319	c.986C>T	c.(985-987)gCg>gTg	p.A329V	TRUB2_ENST00000546104.1_Missense_Mutation_p.A273V	NM_015679.1	NP_056494.1	O95900	TRUB2_HUMAN	TruB pseudouridine (psi) synthase family member 2	329					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding	p.A329V(1)		kidney(2)|large_intestine(2)|lung(3)|ovary(1)	8						TCACTGCCCCGCACCCCTCTC	0.617000													9	26					0	0	0.335167	0	0
ZZEF1	23140	broad.mit.edu	37	17	3990763	3990763	+	Silent	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr17:3990763C>T	ENST00000381638.2	-	14	2431	c.2307G>A	c.(2305-2307)caG>caA	p.Q769Q	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	769							calcium ion binding|zinc ion binding	p.Q769Q(1)		central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						TCCAGAAGATCTGCAAATCAA	0.303000													8	41					0	0	0.335167	0	0
SYNE1	23345	broad.mit.edu	37	6	152671318	152671318	+	Silent	SNP	T	T	C			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr6:152671318T>C	ENST00000367255.5	-	72	12487	c.11886A>G	c.(11884-11886)caA>caG	p.Q3962Q	SYNE1_ENST00000423061.1_Intron|SYNE1_ENST00000265368.4_Silent_p.Q3962Q|SYNE1_ENST00000448038.1_Intron|SYNE1_ENST00000341594.5_Silent_p.Q3886Q	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3962					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.Q3962Q(2)		NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGTGGGCCAATTGCTGGGTGA	0.557000										HNSCC(10;0.0054)			9	41					0	0	0.361761	0	0
PSMC2	5701	broad.mit.edu	37	7	103006539	103006539	+	Missense_Mutation	SNP	G	G	A			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr7:103006539G>A	ENST00000435765.1	+	10	1184	c.773G>A	c.(772-774)cGt>cAt	p.R258H	SLC26A5_ENST00000339444.6_Intron|SLC26A5_ENST00000393735.2_Intron|SLC26A5_ENST00000356767.4_Intron|PSMC2_ENST00000292644.3_Missense_Mutation_p.R258H|PSMC2_ENST00000544811.1_Missense_Mutation_p.R121H	NM_002803.3	NP_002794.1	P35998	PRS7_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 2	258					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding	p.R258H(1)		breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	21						CGAATGGTTCGTGAACTCTTT	0.313000													25	91					0	0	0.729181	0	0
FRMD8	83786	broad.mit.edu	37	11	65172387	65172387	+	Missense_Mutation	SNP	C	C	T			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr11:65172387C>T	ENST00000317568.5	+	10	1287	c.1124C>T	c.(1123-1125)gCg>gTg	p.A375V	FRMD8_ENST00000416776.2_Missense_Mutation_p.A341V|FRMD8_ENST00000355991.5_Missense_Mutation_p.A319V	NM_031904.3	NP_114110.1	Q9BZ67	FRMD8_HUMAN	FERM domain containing 8	375	FERM.					cytoskeleton	binding	p.A375V(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|urinary_tract(1)	17						AGCCAGGCGGCGGAGCCCGCA	0.682000													7	37					0	0	0.335167	0	0
RSPRY1	89970	broad.mit.edu	37	16	57261295	57261295	+	Frame_Shift_Del	DEL	T	T	-			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr16:57261295delT	ENST00000537866.1	+	11	2076	c.1203delT	c.(1201-1203)tafs	p.Y401fs	RSPRY1_ENST00000563073.1_3'UTR|RSPRY1_ENST00000394420.4_Frame_Shift_Del_p.Y401fs			Q96DX4	RSPRY_HUMAN	ring finger and SPRY domain containing 1	401	B30.2/SPRY.					extracellular region	zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|urinary_tract(3)	27						CCTGTGCGTATGATGGCTGCC	0.483													13	40	---	---	---	---					
OR7G1	125962	broad.mit.edu	37	19	9226266	9226266	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-5944-01A-11D-1753-08	TCGA-50-5944-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a314ee0c-694b-4ac8-b572-ff1fbbda4765	c84c2300-f61a-4475-800d-75efe77a7716	g.chr19:9226266delG	ENST00000293614.1	-	1	173	c.174delC	c.(172-174)ccfs	p.P58fs	OR7G1_ENST00000541538.1_Frame_Shift_Del_p.P58fs			Q8NGA0	OR7G1_HUMAN	olfactory receptor, family 7, subfamily G, member 1	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	20						GGAAGTACATGGGGGTGTGGA	0.483													53	38	---	---	---	---