Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ITSN1	6453	broad.mit.edu	37	21	35147397	35147397	+	Silent	SNP	A	A	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr21:35147397A>G	ENST00000381318.3	+	14	1869	c.1581A>G	c.(1579-1581)ctA>ctG	p.L527L	ITSN1_ENST00000381285.4_Silent_p.L527L|ITSN1_ENST00000381291.4_Silent_p.L527L|ITSN1_ENST00000399349.1_Silent_p.L527L|ITSN1_ENST00000399352.1_Silent_p.L527L|AP000304.12_ENST00000429238.1_Intron|ITSN1_ENST00000399353.1_Silent_p.L490L|ITSN1_ENST00000399367.3_Silent_p.L527L|ITSN1_ENST00000399326.3_Silent_p.L527L|ITSN1_ENST00000399338.4_Silent_p.L527L|ITSN1_ENST00000379960.5_Silent_p.L527L|ITSN1_ENST00000437442.2_Silent_p.L527L|ITSN1_ENST00000399355.2_Silent_p.L527L	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	527	KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						TCACCCATCTACAGCAACAAT	0.353000													6	34					0	0	1	0	0
ZNF92	168374	broad.mit.edu	37	7	64863705	64863705	+	Silent	SNP	A	A	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr7:64863705A>G	ENST00000328747.7	+	4	877	c.678A>G	c.(676-678)gaA>gaG	p.E226E	ZNF92_ENST00000431504.1_Silent_p.E150E|ZNF92_ENST00000450302.2_Silent_p.E157E|ZNF92_ENST00000357512.2_Silent_p.E194E	NM_152626.2	NP_689839.1	Q03936	ZNF92_HUMAN	zinc finger protein 92	226						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				ATACTGGAGAAAAACCCTACA	0.338000													3	58					0	0	1	0	0
BTN2A2	10385	broad.mit.edu	37	6	26384103	26384103	+	Silent	SNP	C	C	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr6:26384103C>G	ENST00000356709.4	+	2	165	c.54C>G	c.(52-54)ctC>ctG	p.L18L	BTN2A2_ENST00000416795.2_Silent_p.L18L|BTN2A2_ENST00000469230.1_Silent_p.L18L|BTN2A2_ENST00000432533.2_Silent_p.L18L|BTN2A2_ENST00000352867.2_Silent_p.L18L|BTN2A2_ENST00000482536.1_Silent_p.L18L	NM_001197240.1|NM_006995.4	NP_001184169.1|NP_008926.2	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2	18					negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane				breast(2)|endometrium(3)|large_intestine(5)|lung(13)	23						tcctcctcctcctgctcctcc	0.587000													3	71					0	0	1	0	0
DPYSL2	1808	broad.mit.edu	37	8	26441458	26441458	+	Missense_Mutation	SNP	A	A	G	rs113269672		TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr8:26441458A>G	ENST00000311151.5	+	3	684	c.272A>G	c.(271-273)cAa>cGa	p.Q91R	DPYSL2_ENST00000523027.1_Missense_Mutation_p.Q55R|DPYSL2_ENST00000521913.1_Missense_Mutation_p.Q55R	NM_001386.5	NP_001377.1	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	91					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			breast(1)|endometrium(5)|large_intestine(8)|lung(3)|prostate(1)|skin(1)|stomach(1)	20		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		GATTTCTTCCAAGGAACCAAG	0.498000													18	84					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134158730	134158730	+	Silent	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr11:134158730G>A	ENST00000389887.5	+	7	3171	c.675G>A	c.(673-675)gaG>gaA	p.E225E	GLB1L3_ENST00000431683.2_Silent_p.E225E			Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	225					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TGCAAGTGGAGAATGAGTATG	0.502000													5	26					0	0	1	0	0
WBP11	51729	broad.mit.edu	37	12	14947586	14947586	+	Silent	SNP	A	A	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:14947586A>G	ENST00000261167.2	-	7	839	c.606T>C	c.(604-606)ccT>ccC	p.P202P	WBP11_ENST00000537574.1_Silent_p.P202P	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	202	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						GACCAGGGGGAGGGCCAGGAG	0.512000													4	114					0	0	1	0	0
RRP1	8568	broad.mit.edu	37	21	45220445	45220445	+	Silent	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr21:45220445C>T	ENST00000497547.1	+	10	1056	c.939C>T	c.(937-939)cgC>cgT	p.R313R	RRP1_ENST00000471909.1_3'UTR	NM_003683.5	NP_003674.1	P56182	RRP1_HUMAN	ribosomal RNA processing 1	313					rRNA processing	nucleolus|preribosome, small subunit precursor				central_nervous_system(1)|kidney(1)|lung(4)|stomach(2)	8				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		TGGCCAGCCGCCAGAGCACCC	0.552000													4	24					0	0	1	0	0
DRAM1	55332	broad.mit.edu	37	12	102315025	102315025	+	Missense_Mutation	SNP	A	A	G	rs61748066		TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:102315025A>G	ENST00000258534.8	+	7	1143	c.704A>G	c.(703-705)aAt>aGt	p.N235S	DRAM1_ENST00000544152.1_Missense_Mutation_p.N125S	NM_018370.2	NP_060840.2	Q8N682	DRAM1_HUMAN	DNA-damage regulated autophagy modulator 1	235					apoptosis|autophagy	integral to membrane|lysosomal membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(1)	12						ACAGAAATCAATGGTGATATT	0.388000													14	76					0	0	1	0	0
ALPK1	80216	broad.mit.edu	37	4	113356393	113356393	+	Nonsense_Mutation	SNP	A	A	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr4:113356393A>T	ENST00000458497.1	+	12	3403	c.3124A>T	c.(3124-3126)Aaa>Taa	p.K1042*	ALPK1_ENST00000504176.2_Nonsense_Mutation_p.K964*|ALPK1_ENST00000177648.9_Nonsense_Mutation_p.K1042*	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1042	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		GACTGTGAAGAAAAAAGGCAG	0.348000													11	111					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20600000	20600000	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr20:20600000A>C	ENST00000202677.6	-	12	1602	c.1460T>G	c.(1459-1461)tTc>tGc	p.F487C		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	487					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						TGCACTTGTGAAGGAGTATGT	0.483000													3	13					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79733547	79733547	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr5:79733547G>C	ENST00000338008.5	+	3	1223	c.1043G>C	c.(1042-1044)aGt>aCt	p.S348T	ZFYVE16_ENST00000510158.1_Missense_Mutation_p.S348T|ZFYVE16_ENST00000505560.1_Missense_Mutation_p.S348T	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	348					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		GACTCAAAAAGTTTAGACCTT	0.353000													10	27					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31644125	31644125	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr14:31644125C>A	ENST00000399332.1	-	4	1083	c.595G>T	c.(595-597)Gat>Tat	p.D199Y	HECTD1_ENST00000553700.1_Missense_Mutation_p.D199Y	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	199					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		ACCTGATGATCTTCATGCTTT	0.338000													3	17					1	1	1	1	0
PRSS3P2	154754	broad.mit.edu	37	7	142482242	142482242	+	RNA	SNP	G	G	A	rs143538588	by1000genomes	TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr7:142482242G>A	ENST00000603901.1	+	0	622					NR_001296.3																						GGTCTGCAATGGACAGCTTCA	0.493000													3	32					0	0	1	0	0
TOP1MT	116447	broad.mit.edu	37	8	144406735	144406735	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr8:144406735C>T	ENST00000523676.1	-	7	847	c.442G>A	c.(442-444)Gtc>Atc	p.V148I	TOP1MT_ENST00000519148.1_Missense_Mutation_p.V148I|TOP1MT_ENST00000329245.4_Missense_Mutation_p.V246I|TOP1MT_ENST00000521193.1_Missense_Mutation_p.V148I			Q969P6	TOP1M_HUMAN	topoisomerase (DNA) I, mitochondrial	246					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	23	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	AGCCACGTGACGGTGTTATCG	0.592000													6	113					0	0	1	0	0
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr19:49926533G>C	ENST00000270631.1	-	1	165	c.64C>G	c.(64-66)Ctg>Gtg	p.L22V		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	22					neuropeptide signaling pathway	extracellular region		p.L22V(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.692000													3	25					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140625619	140625619	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr5:140625619G>A	ENST00000231173.3	+	1	473	c.473G>A	c.(472-474)cGg>cAg	p.R158Q		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		158	Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAAAAGCTCGGGACTTGGAC	0.448000													3	38					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	27					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62839705	62839705	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr20:62839705G>A	ENST00000536311.1	+	7	1520	c.1156G>A	c.(1156-1158)Gcc>Acc	p.A386T	MYT1_ENST00000360149.4_Intron|MYT1_ENST00000328439.1_Missense_Mutation_p.A386T			Q01538	MYT1_HUMAN	myelin transcription factor 1	386					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GCAGGCCATCGCCCTGAAGGC	0.662000													9	32					0	0	1	0	0
OGT	8473	broad.mit.edu	37	X	70775057	70775057	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chrX:70775057T>A	ENST00000373719.3	+	7	963	c.746T>A	c.(745-747)cTt>cAt	p.L249H	OGT_ENST00000373701.3_Missense_Mutation_p.L239H	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	249					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					GCAGCTTATCTTCGTGCCCTA	0.458000													3	16					0	0	1	0	0
ARHGEF9	23229	broad.mit.edu	37	X	62944546	62944546	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chrX:62944546G>A	ENST00000253401.6	-	2	855	c.55C>T	c.(55-57)Cac>Tac	p.H19Y	ARHGEF9_ENST00000495564.1_5'UTR|ARHGEF9_ENST00000374872.1_5'UTR|ARHGEF9_ENST00000374878.1_Missense_Mutation_p.H17Y|ARHGEF9_ENST00000437457.2_Intron|ARHGEF9_ENST00000374870.4_Intron	NM_015185.2	NP_056000.1	O43307	ARHG9_HUMAN	Cdc42 guanine nucleotide exchange factor (GEF) 9	19	SH3.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(14)|ovary(5)|pancreas(1)|skin(1)	35						ATGGTGACGTGATCCCATACT	0.512000													3	38					0	0	1	0	0
FAM129C	199786	broad.mit.edu	37	19	17660359	17660359	+	Silent	SNP	G	G	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr19:17660359G>T	ENST00000595684.1	+	15	2004	c.1866G>T	c.(1864-1866)ctG>ctT	p.L622L	FAM129C_ENST00000352727.3_Intron|FAM129C_ENST00000332386.5_Intron|FAM129C_ENST00000599164.1_Intron|FAM129C_ENST00000449408.2_Intron|FAM129C_ENST00000601861.1_Intron|FAM129C_ENST00000599124.1_Intron|FAM129C_ENST00000335393.4_Intron|FAM129C_ENST00000600871.1_Intron			Q86XR2	NIBL2_HUMAN	family with sequence similarity 129, member C	0										autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(2)|lung(14)|ovary(1)|skin(3)|stomach(1)	33						ACAGGCTTCTGAAACATGCCA	0.552000													3	19					0.115264	0.119171	1	1	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000404276.1_Silent_p.S372S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	26					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31810592	31810592	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr10:31810592C>G	ENST00000446923.2	+	7	2672	c.2281C>G	c.(2281-2283)Cca>Gca	p.P761A	ZEB1_ENST00000542815.3_Missense_Mutation_p.P710A|ZEB1_ENST00000320985.10_Missense_Mutation_p.P777A|ZEB1_ENST00000560721.2_Missense_Mutation_p.P757A|ZEB1_ENST00000361642.5_Missense_Mutation_p.P778A|ZEB1_ENST00000559858.1_3'UTR	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	777					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AAAAAAGGAGCCACAAAAGGA	0.423000													12	53					0	0	1	0	0
ZNF83	55769	broad.mit.edu	37	19	53116801	53116801	+	Silent	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr19:53116801G>A	ENST00000597597.1	-	2	3270	c.1017C>T	c.(1015-1017)caC>caT	p.H339H	ZNF83_ENST00000391789.4_Silent_p.H311H|ZNF83_ENST00000601257.1_Intron|ZNF83_ENST00000600714.1_Intron|ZNF83_ENST00000301096.3_Silent_p.H339H|ZNF83_ENST00000544146.1_Silent_p.H339H|ZNF83_ENST00000541777.2_Silent_p.H339H|ZNF83_ENST00000536937.1_Silent_p.H339H|ZNF83_ENST00000545872.1_Silent_p.H339H			P51522	ZNF83_HUMAN	zinc finger protein 83	339						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		TCTCTCCAGTGTGGATTCTCC	0.418000													5	129					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38798590	38798590	+	Silent	SNP	G	G	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr3:38798590G>C	ENST00000449082.2	-	8	1010	c.1011C>G	c.(1009-1011)acC>acG	p.T337T		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	337					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	AATCAAAGCTGGTGTAGTTAA	0.502000													9	39					0	0	1	0	0
ID2	3398	broad.mit.edu	37	2	8822342	8822342	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr2:8822342C>T	ENST00000234091.4	+	3	907	c.47C>T	c.(46-48)tCg>tTg	p.S16L	ID2_ENST00000396290.1_Missense_Mutation_p.S16L|ID2_ENST00000331129.3_Missense_Mutation_p.S16L			Q02363	ID2_HUMAN	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	16					cellular senescence|embryonic digestive tract morphogenesis|endodermal digestive tract morphogenesis|epithelial cell differentiation involved in mammary gland alveolus development|mammary gland epithelial cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of neuron differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|neuron fate commitment|positive regulation of blood pressure|positive regulation of cell cycle arrest|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent	protein complex	protein binding			breast(1)|large_intestine(1)|lung(1)|prostate(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AACAGCCTGTCGGACCACAGC	0.597000													5	39					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028425	37028425	+	Missense_Mutation	SNP	A	A	G	rs145580328	byFrequency	TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chrX:37028425A>G	ENST00000358047.3	+	1	1994	c.1942A>G	c.(1942-1944)Aat>Gat	p.N648D		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	648								p.N648D(7)		breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGAGCCTCCCAATACTGGAGT	0.642000													3	50					0	0	1	0	0
KRT16P2	400578	broad.mit.edu	37	17	16734770	16734770	+	RNA	SNP	C	C	T	rs659229		TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr17:16734770C>T	ENST00000579062.1	-	0	545																											TCAGGCCTTCCATCTGCATCT	0.627000													3	60					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102294648	102294648	+	RNA	SNP	T	T	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr15:102294648T>C	ENST00000561463.1	+	0	2694																											TTCTCAGAGCTGCTGTCCAAC	0.587000													4	34					0	0	1	0	0
SKA1	220134	broad.mit.edu	37	18	47911673	47911673	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr18:47911673T>A	ENST00000285116.3	+	5	610	c.399T>A	c.(397-399)agT>agA	p.S133R	SKA1_ENST00000488454.1_Intron|SKA1_ENST00000417656.2_Intron|SKA1_ENST00000398452.2_Missense_Mutation_p.S133R	NM_001039535.2|NM_145060.3	NP_001034624.1|NP_659497.1	Q96BD8	SKA1_HUMAN	spindle and kinetochore associated complex subunit 1	133					cell division|chromosome segregation|mitotic anaphase|mitotic prometaphase|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytosol|spindle microtubule	microtubule binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(1)|prostate(1)	13						AGCAAAGAAGTATTAAGGAAA	0.348000													3	29					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48454284	48454284	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr3:48454284C>G	ENST00000358536.4	-	25	4990	c.4721G>C	c.(4720-4722)aGg>aCg	p.R1574T	PLXNB1_ENST00000448774.2_Missense_Mutation_p.R185T|PLXNB1_ENST00000358459.4_Missense_Mutation_p.R1391T|PLXNB1_ENST00000296440.6_Missense_Mutation_p.R1574T|PLXNB1_ENST00000456774.1_Missense_Mutation_p.R1391T	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1574					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAAGAAGATCCTCTCCGCATA	0.612000													8	71					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20489434	20489434	+	RNA	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr15:20489434C>T	ENST00000555186.1	+	0	422					NR_038836.1																						CACTGAAGGACCAGATCACCA	0.413000													4	51					0	0	1	0	0
CD109	135228	broad.mit.edu	37	6	74497176	74497176	+	Splice_Site	SNP	G	G	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr6:74497176G>T	ENST00000437994.2	+	21	2987		c.e21+1		CD109_ENST00000422508.2_Splice_Site|CD109_ENST00000287097.5_Splice_Site	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule							anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TTTAGTAAAGGTAAATATTTG	0.378000													10	30					3.03607e-14	3.49435e-14	1	1	0
TTN	7273	broad.mit.edu	37	2	179592542	179592542	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr2:179592542T>A	ENST00000589042.1	-	68	19987	c.19763A>T	c.(19762-19764)gAt>gTt	p.D6588V	TTN_ENST00000591111.1_Missense_Mutation_p.D6271V|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D5344V|TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6271	Ig-like 47.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGTAGAATCAGGTATGGC	0.353000													8	22					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48622705	48622705	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr4:48622705C>A	ENST00000358350.4	-	6	869	c.265G>T	c.(265-267)Gaa>Taa	p.E89*	FRYL_ENST00000503238.1_Nonsense_Mutation_p.E89*|FRYL_ENST00000507711.1_Nonsense_Mutation_p.E89*|FRYL_ENST00000537810.1_Nonsense_Mutation_p.E89*|FRYL_ENST00000264319.7_5'UTR	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						GATTCATCTTCCGTTCCATTT	0.428000													7	74					1.12685e-05	1.24978e-05	1	1	0
PCLO	27445	broad.mit.edu	37	7	82763935	82763935	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr7:82763935T>G	ENST00000423517.2	-	3	3268	c.2931A>C	c.(2929-2931)caA>caC	p.Q977H	PCLO_ENST00000333891.8_Missense_Mutation_p.Q977H	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	923					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGGGTGGCCCTTGTGAAGTAG	0.507000													4	14					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37431050	37431050	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr10:37431050G>C	ENST00000374660.1	+	7	1156	c.1057G>C	c.(1057-1059)Gca>Cca	p.A353P	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.A353P|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.A353P			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	409						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.A353P(1)		NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ATTTACGTGGGCAGCAAAAGG	0.408000													4	34					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11693	11693	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chrM:11693G>A	ENST00000361381.2	+	1	934	c.934G>A	c.(934-936)Gca>Aca	p.312_312insT						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						GCTTCACCGGCGCAGTCATTC	0.473000													19	10					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43258606	43258606	+	Silent	SNP	T	T	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr19:43258606T>A	ENST00000404209.4	-	5	1218	c.1122A>T	c.(1120-1122)ctA>ctT	p.L374L	PSG8_ENST00000306511.4_Silent_p.L374L|PSG8_ENST00000406636.3_Silent_p.L252L|PSG8_ENST00000600709.1_5'UTR|PSG8_ENST00000401467.2_Silent_p.L281L	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	374	Ig-like C2-type 3.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				TTTGTCCTGATAGCTGAAACT	0.463000													21	212					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142482229	142482229	+	RNA	SNP	T	T	A	rs145494190	by1000genomes	TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr7:142482229T>A	ENST00000603901.1	+	0	609					NR_001296.3													p.P203P(1)									CTGGTGGCCCTGTGGTCTGCA	0.493000													3	28					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20760303	20760303	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr22:20760303C>T	ENST00000400451.2	+	5	1494	c.980C>T	c.(979-981)aCg>aTg	p.T327M	ZNF74_ENST00000405993.1_Missense_Mutation_p.T295M|ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000356671.5_Missense_Mutation_p.T327M|ZNF74_ENST00000357502.5_3'UTR	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	327					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CGCATCCACACGGGCGAGCGG	0.672000													7	38					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68140474	68140474	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr8:68140474C>A	ENST00000262215.3	-	24	3795	c.3406G>T	c.(3406-3408)Gat>Tat	p.D1136Y	ARFGEF1_ENST00000520381.1_Missense_Mutation_p.D590Y|ARFGEF1_ENST00000518230.1_5'UTR	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	1136					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GCATTTCCATCTAGCCTTGTA	0.308000													9	102					0.00829132	0.00903161	1	1	0
DNM1P47	100216544	broad.mit.edu	37	15	102294651	102294651	+	RNA	SNP	T	T	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr15:102294651T>G	ENST00000561463.1	+	0	2697																											TCAGAGCTGCTGTCCAACCTG	0.587000													3	35					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77611877	77611877	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr3:77611877G>T	ENST00000461745.1	+	10	2413	c.1513G>T	c.(1513-1515)Gtg>Ttg	p.V505L	ROBO2_ENST00000487694.3_Missense_Mutation_p.V521L|ROBO2_ENST00000332191.8_Missense_Mutation_p.V505L	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	505					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AGTGCTGGATGTGACAGGTGA	0.423000													7	28					1.06961e-07	1.20827e-07	1	1	0
SMG5	23381	broad.mit.edu	37	1	156243215	156243215	+	Missense_Mutation	SNP	C	C	A	rs147611925	byFrequency	TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr1:156243215C>A	ENST00000361813.5	-	6	715	c.571G>T	c.(571-573)Gta>Tta	p.V191L	SMG5_ENST00000368267.4_Missense_Mutation_p.V191L	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	191					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					TCGGTATCTACGCCAGCTAAT	0.483000													7	42					0.0477658	0.0502364	1	1	0
PNKD	25953	broad.mit.edu	37	2	219137330	219137330	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr2:219137330C>T	ENST00000248451.3	+	3	418	c.274C>T	c.(274-276)Ctc>Ttc	p.L92F	PNKD_ENST00000273077.4_Intron|PNKD_ENST00000472650.1_Intron	NM_001077399.2	NP_001070867.1	Q8N490	PNKD_HUMAN	paroxysmal nonkinesigenic dyskinesia	0						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	10		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTCTTCATCCTCACCAAGCG	0.607000											OREG0015199	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	135					0	0	1	0	0
MT-CO1	4512	broad.mit.edu	37	MT	5978	5978	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chrM:5978A>G	ENST00000361624.2	+	1	75	c.75A>G	c.(73-75)tgA>tgG	p.25_25insW						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						TTCGGCGCATGAGCTGGAGTC	0.507000													4	9					0	0	1	0	0
KCNA5	3741	broad.mit.edu	37	12	5154827	5154827	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:5154827T>C	ENST00000252321.3	+	1	1743	c.1514T>C	c.(1513-1515)gTc>gCc	p.V505A		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	505						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						ATCGCCGGGGTCCTCACCATT	0.607000													8	59					0	0	1	0	0
IL26	55801	broad.mit.edu	37	12	68619484	68619484	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:68619484A>T	ENST00000229134.4	-	1	117	c.53T>A	c.(52-54)cTt>cAt	p.L18H	IFNG-AS1_ENST00000536914.1_RNA	NM_018402.1	NP_060872.1	Q9NPH9	IL26_HUMAN	interleukin 26	18					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		GGCAATGGCAAGAGACAGAGT	0.483000													25	96					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162556	90162556	+	RNA	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr16:90162556G>A	ENST00000564451.1	+	0	1909				TUBB8P7_ENST00000567960.1_RNA														p.E430*(1)									TGCCACGGCCGAGGAGGAGGA	0.517000													4	122					0	0	1	0	0
KRTAP4-2	85291	broad.mit.edu	37	17	39334280	39334280	+	Missense_Mutation	SNP	C	C	A	rs147637076	by1000genomes	TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr17:39334280C>A	ENST00000377726.2	-	1	180	c.137G>T	c.(136-138)tGc>tTc	p.C46F		NM_033062.3	NP_149051.1	Q9BYR5	KRA42_HUMAN	keratin associated protein 4-2	46	20 X 5 AA repeats OF C-C-[GRQVS]-[SPT]- [VSTQ].					keratin filament				kidney(2)|lung(4)|upper_aerodigestive_tract(1)	7		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			CTGCGGTCTGCAGCAGCTGGA	0.677000													4	99					0.00909568	0.00973397	1	1	0
ITPRIPL1	150771	broad.mit.edu	37	2	96992793	96992795	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr2:96992793_96992795delGAG	ENST00000361124.4	+	1	859_861	c.448_450delGAG	c.(448-450)del	p.E155del	ITPRIPL1_ENST00000536814.1_In_Frame_Del_p.E139del|ITPRIPL1_ENST00000439118.2_In_Frame_Del_p.E147del|ITPRIPL1_ENST00000542887.1_In_Frame_Del_p.E139del	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	147						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTCCAGCAGTGAGGAGGAGGAGG	0.532													7	50	---	---	---	---					
ANKRD44	91526	broad.mit.edu	37	2	197943383	197943384	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr2:197943383_197943384delTG	ENST00000409153.1	-	16	1875_1876	c.1693_1694delCA	c.(1693-1695)tfs	p.H565fs	ANKRD44_ENST00000539527.1_Frame_Shift_Del_p.H493fs|ANKRD44_ENST00000337207.5_Intron|ANKRD44_ENST00000450567.1_Intron|ANKRD44_ENST00000282272.8_Intron|ANKRD44_ENST00000328737.2_Intron			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	811							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			ATTTGGGGTATGTGTGTGTGTG	0.411													4	6	---	---	---	---					
GLT8D1	55830	broad.mit.edu	37	3	52730605	52730609	+	Frame_Shift_Del	DEL	CCAAA	CCAAA	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr3:52730605_52730609delCCAAA	ENST00000407584.3	-	6	1246_1250	c.396_400delTTTGG	c.(394-402)ctaafs	p.LLE132fs	GLT8D1_ENST00000266014.5_Frame_Shift_Del_p.LLE132fs|GLT8D1_ENST00000394783.3_Frame_Shift_Del_p.LLE132fs|GLT8D1_ENST00000478968.2_Frame_Shift_Del_p.LLE132fs|GLT8D1_ENST00000491606.1_Frame_Shift_Del_p.LLE132fs|GLT8D1_ENST00000463827.1_5'UTR	NM_001010983.1|NM_001278280.1	NP_001010983.1|NP_001265209.1	Q68CQ7	GL8D1_HUMAN	glycosyltransferase 8 domain containing 1	132						integral to membrane|mitochondrion	transferase activity, transferring glycosyl groups			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)	8				BRCA - Breast invasive adenocarcinoma(193;6.78e-05)|Kidney(197;0.000618)|KIRC - Kidney renal clear cell carcinoma(197;0.000779)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ACTTTTCCTTCCAAAAGTTTAGGGT	0.390													7	30	---	---	---	---					
WWC2	80014	broad.mit.edu	37	4	184182555	184182555	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr4:184182555delT	ENST00000403733.3	+	11	1978	c.1779delT	c.(1777-1779)cafs	p.H593fs	WWC2_ENST00000378925.3_Frame_Shift_Del_p.H495fs|WWC2_ENST00000448232.2_Frame_Shift_Del_p.H593fs|WWC2_ENST00000513834.1_Intron|WWC2_ENST00000504005.1_Frame_Shift_Del_p.H275fs	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	593										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		TGAGTAGCCATTTTGCAGATA	0.448													2	4	---	---	---	---					
MTUS1	57509	broad.mit.edu	37	8	17611606	17611606	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr8:17611606delT	ENST00000381869.3	-	2	2184	c.1711delA	c.(1711-1713)ttfs	p.I571fs	MTUS1_ENST00000381862.3_Frame_Shift_Del_p.I571fs|MTUS1_ENST00000519263.1_Frame_Shift_Del_p.I571fs|MTUS1_ENST00000262102.6_Frame_Shift_Del_p.I571fs	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	571						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		GTCTTGTTAATTAGAATTTCT	0.398													42	198	---	---	---	---					
FAM166B	730112	broad.mit.edu	37	9	35562393	35562394	+	Frame_Shift_Ins	INS	-	-	TAGT	rs142582869	by1000genomes	TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr9:35562393_35562394insTAGT	ENST00000399742.2	-	5	792_793	c.722_723insACTA	c.(721-723)tggfs	p.W241fs	FAM166B_ENST00000492890.1_5'UTR	NM_001099951.2|NM_001164310.1	NP_001093421.1|NP_001157782.1	A8MTA8	F166B_HUMAN	family with sequence similarity 166, member B	241								p.Y225fs*1(1)		kidney(3)|large_intestine(1)|lung(4)|ovary(1)	9						CGTAGCCCCCATAGTTAGGTAA	0.564													4	3	---	---	---	---					
ZNF367	195828	broad.mit.edu	37	9	99180258	99180259	+	In_Frame_Ins	INS	-	-	GGC			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr9:99180258_99180259insGGC	ENST00000375256.4	-	1	352_353	c.56_57insGCC	c.(55-57)cgt>cGCCgt	p.19_19R>RR		NM_153695.3	NP_710162.1	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	19	Pro-rich.				regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(4)|large_intestine(3)|lung(3)|prostate(1)	12		Acute lymphoblastic leukemia(62;0.0167)				AGAAGATGACGggcggcggcgg	0.752													6	7	---	---	---	---					
KRT76	51350	broad.mit.edu	37	12	53162773	53162775	+	In_Frame_Del	DEL	ACT	ACT	-	rs1464423	by1000genomes	TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:53162773_53162775delACT	ENST00000332411.2	-	9	1692_1694	c.1639_1641delAGT	c.(1639-1641)del	p.S547del		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	547	Tail.				cytoskeleton organization	keratin filament	structural molecule activity	p.S547_G548insS(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ctccatagccactgctgctgctg	0.635													3	6	---	---	---	---					
LRRIQ1	84125	broad.mit.edu	37	12	85449409	85449409	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:85449409delT	ENST00000393217.2	+	8	899	c.838delT	c.(838-840)tafs	p.L280fs		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	280	Glu-rich.									breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		AAATTCTTTGTTAAAACAGCA	0.274													7	21	---	---	---	---					
CTD-2377D24.8	0	broad.mit.edu	37	17	46777522	46777524	+	RNA	DEL	GGA	GGA	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr17:46777522_46777524delGGA	ENST00000575202.1	+	0	51																											ggaggaagggggaggaggaggag	0.537													2	4	---	---	---	---					
ITGB4	3691	broad.mit.edu	37	17	73732157	73732158	+	Frame_Shift_Del	DEL	GT	GT	-	rs121912463		TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr17:73732157_73732158delGT	ENST00000200181.3	+	14	1870_1871	c.1683_1684delGT	c.(1681-1686)cagtfs	p.QC561fs	ITGB4_ENST00000339591.3_Frame_Shift_Del_p.QC561fs|ITGB4_ENST00000579662.1_Frame_Shift_Del_p.QC561fs|ITGB4_ENST00000450894.3_Frame_Shift_Del_p.QC561fs|ITGB4_ENST00000449880.2_Frame_Shift_Del_p.QC561fs|ITGB4_ENST00000584558.1_3'UTR	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	561	Cysteine-rich tandem repeats.				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCATGGGCCAGTGTGTGTGTGA	0.604													7	260	---	---	---	---					
RP11-739N10.1	0	broad.mit.edu	37	18	24935152	24935157	+	RNA	DEL	CATCAT	CATCAT	-	rs36161350		TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr18:24935152_24935157delCATCAT	ENST00000584546.1	-	0	447																											accaccactacatcatcatcatcatc	0.481													3	5	---	---	---	---