Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ALOX15	246	broad.mit.edu	37	17	4535037	4535037	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr17:4535037C>T	ENST00000570836.1	-	15	1943	c.1847G>A	c.(1846-1848)gGc>gAc	p.G616D	ALOX15_ENST00000293761.3_Missense_Mutation_p.G616D|ALOX15_ENST00000574640.1_Missense_Mutation_p.G577D|ALOX15_ENST00000545513.1_Missense_Mutation_p.G638D			P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	616	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(5)	20				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	AGGCTCAGGGCCCGAAAAATA	0.572000													6	161					0	0	0.217242	0	0
UBBP4	23666	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000584398.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													4	123					0	0	0.150653	0	0
ZNF733P	643955	broad.mit.edu	37	7	62752443	62752443	+	RNA	SNP	G	G	C			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr7:62752443G>C	ENST00000331425.6	-	0	992					NR_003952.1																						CTTATGTCTAGTAAGGTTTGA	0.438000													3	32					0	0	0.115264	0	0
IGKV1D-43	28891	broad.mit.edu	37	2	90249265	90249265	+	RNA	SNP	C	C	A			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr2:90249265C>A	ENST00000468879.1	+	0	402																											TATTATGCATCCAGTTTGCAA	0.498000													13	234					4.36969e-10	5.26349e-10	0.435327	1	0
AHI1	54806	broad.mit.edu	37	6	135784313	135784313	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr6:135784313T>C	ENST00000367800.4	-	6	1097	c.881A>G	c.(880-882)cAa>cGa	p.Q294R	AHI1_ENST00000457866.2_Missense_Mutation_p.Q294R|AHI1_ENST00000327035.6_Missense_Mutation_p.Q294R	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	294						adherens junction|cilium|microtubule basal body		p.Q294R(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TGTATCATCTTGCATGCTGTC	0.313000													4	70					0	0	0.150653	0	0
SCN8A	6334	broad.mit.edu	37	12	52164405	52164405	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr12:52164405G>A	ENST00000354534.5	+	19	3761	c.3583G>A	c.(3583-3585)Gtg>Atg	p.V1195M	SCN8A_ENST00000545061.1_Missense_Mutation_p.V1195M	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1195					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CTTCCTCATCGTGGAGCACAA	0.567000													3	42					0	0	0.115264	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000556131.1_Missense_Mutation_p.G12D|KRAS_ENST00000256078.4_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			4	28					0	0	0.184627	0	0
RPL5	6125	broad.mit.edu	37	1	93306107	93306107	+	Splice_Site	SNP	G	G	T			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr1:93306107G>T	ENST00000370321.3	+	7	795		c.e7-1			NM_000969.3	NP_000960.2	P46777	RL5_HUMAN	ribosomal protein L5						endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		CTTTGTTTCAGATGGAGGAGA	0.373000													6	111					3.59834e-05	3.97316e-05	0.217242	1	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													6	98					0	0	0.278610	0	0
CDH9	1007	broad.mit.edu	37	5	26915914	26915914	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr5:26915914A>T	ENST00000231021.4	-	3	519	c.347T>A	c.(346-348)cTa>cAa	p.L116Q		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	116	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.L116Q(1)		breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						TTCTCTGTCTAGTTTCTTTGC	0.383000													5	177					0	0	0.184627	0	0
IGKV3-11	28914	broad.mit.edu	37	2	89326699	89326699	+	RNA	SNP	A	A	G			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr2:89326699A>G	ENST00000483158.1	-	0	360																											ACAGTAATAAACTGCAAAATC	0.493000													4	129					0	0	0.184627	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25258179	25258179	+	Silent	SNP	T	T	C			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr16:25258179T>C	ENST00000328086.7	-	5	2141	c.1338A>G	c.(1336-1338)agA>agG	p.R446R		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	446					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		TTCTCTTCAGTCTGGGGACAG	0.483000													5	118					0	0	0.217242	0	0
TG	7038	broad.mit.edu	37	8	134034380	134034380	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr8:134034380G>A	ENST00000220616.4	+	40	7061	c.7021G>A	c.(7021-7023)Ggc>Agc	p.G2341S	TG_ENST00000519543.1_Missense_Mutation_p.G474S|TG_ENST00000377869.1_Missense_Mutation_p.G2284S|TG_ENST00000542445.1_Missense_Mutation_p.G711S	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2341					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGGTGTCTTCGGCTTCCTGAG	0.617000													8	123					0	0	0.278610	0	0
FRG1B	284802	broad.mit.edu	37	20	29625955	29625955	+	Nonsense_Mutation	SNP	A	A	T			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr20:29625955A>T	ENST00000278882.3	+	5	579	c.199A>T	c.(199-201)Aga>Tga	p.R67*	FRG1B_ENST00000439954.2_Nonsense_Mutation_p.R72*|FRG1B_ENST00000358464.4_Nonsense_Mutation_p.R67*																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATTGGACCAAGAGAACAATG	0.338000													4	66					0	0	0.184627	0	0
BABAM1	29086	broad.mit.edu	37	19	17384762	17384762	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr19:17384762G>A	ENST00000359435.4	+	4	587	c.394G>A	c.(394-396)Gtg>Atg	p.V132M	BABAM1_ENST00000448635.2_3'UTR|BABAM1_ENST00000598188.1_Missense_Mutation_p.V132M|BABAM1_ENST00000447614.2_Missense_Mutation_p.V132M|BABAM1_ENST00000595632.1_Intron|CTD-2278I10.6_ENST00000596542.1_Missense_Mutation_p.V54M|BABAM1_ENST00000601043.1_Missense_Mutation_p.V132M	NM_001033549.1	NP_001028721.1	Q9NWV8	BABA1_HUMAN	BRISC and BRCA1 A complex member 1	132	VWFA-like.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|protein K63-linked deubiquitination|response to ionizing radiation	BRCA1-A complex|BRISC complex|cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5						TGAGATGTTCGTGCGGACAAA	0.577000													3	35					0	0	0.115264	0	0
DAPP1	27071	broad.mit.edu	37	4	100761541	100761541	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr4:100761541A>G	ENST00000296414.7	+	3	401	c.320A>G	c.(319-321)aAg>aGg	p.K107R	DAPP1_ENST00000512369.1_Missense_Mutation_p.K107R			Q9UN19	DAPP1_HUMAN	dual adaptor of phosphotyrosine and 3-phosphoinositides	107	SH2.				signal transduction	cytoplasm|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein tyrosine phosphatase activity			endometrium(1)|kidney(1)|lung(4)	6				OV - Ovarian serous cystadenocarcinoma(123;7.04e-09)		GATTTTGTCAAGCATTTTGCA	0.363000													4	35					0	0	0.150653	0	0
CHRM3	1131	broad.mit.edu	37	1	240072343	240072343	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr1:240072343G>T	ENST00000255380.4	+	5	2371	c.1592G>T	c.(1591-1593)tGg>tTg	p.W531L		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	531					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity	p.W531S(2)		breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CTGGGCTACTGGCTGTGCTAC	0.488000													8	103					1.06961e-07	1.25977e-07	0.278610	1	0
SLC39A10	57181	broad.mit.edu	37	2	196593042	196593042	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr2:196593042G>A	ENST00000409086.3	+	9	2581	c.2306G>A	c.(2305-2307)gGc>gAc	p.G769D	SLC39A10_ENST00000541054.1_Missense_Mutation_p.G319D|SLC39A10_ENST00000359634.5_Missense_Mutation_p.G769D	NM_001127257.1	NP_001120729.1	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter), member 10	769					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(16)|pancreas(1)|prostate(1)|skin(2)	34			OV - Ovarian serous cystadenocarcinoma(117;0.221)			GTCACTGCAGGCATGTTCCTC	0.413000													4	132					0	0	0.150653	0	0
ZNF131	7690	broad.mit.edu	37	5	43139296	43139296	+	Missense_Mutation	SNP	A	A	C			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr5:43139296A>C	ENST00000509634.1	+	3	712	c.256A>C	c.(256-258)Att>Ctt	p.I86L	ZNF131_ENST00000399534.1_Missense_Mutation_p.I86L|ZNF131_ENST00000509156.1_Missense_Mutation_p.I86L|ZNF131_ENST00000505606.2_Missense_Mutation_p.I86L|ZNF131_ENST00000306938.4_Missense_Mutation_p.I86L|ZNF131_ENST00000509931.1_Intron			P52739	ZN131_HUMAN	zinc finger protein 131	86	BTB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	17						TCGCCATTTAATTGAGTTCAC	0.328000													4	94					0	0	0.184627	0	0
SYNCRIP	10492	broad.mit.edu	37	6	86329003	86329003	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr6:86329003G>C	ENST00000355238.6	-	9	1347	c.1141C>G	c.(1141-1143)Cga>Gga	p.R381G	SYNCRIP_ENST00000369622.3_Missense_Mutation_p.R381G	NM_001159673.1|NM_001159674.1|NM_001159676.1|NM_001159677.1|NM_001253771.1	NP_001153145.1|NP_001153146.1|NP_001153148.1|NP_001153149.1|NP_001240700.1	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA interacting protein	381	RRM 3.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		GCACCATCTCGCTCATCAAAA	0.333000													7	83					0	0	0.335167	0	0
DOCK2	1794	broad.mit.edu	37	5	169504819	169504819	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr5:169504819C>A	ENST00000256935.8	+	48	5052	c.4972C>A	c.(4972-4974)Ccc>Acc	p.P1658T	DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Missense_Mutation_p.P719T|DOCK2_ENST00000520908.1_Missense_Mutation_p.P1150T	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1658					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGCAGCACCCCCAGCAAGCC	0.597000													4	51					0.00909568	0.00983818	0.150653	1	0
FAT3	120114	broad.mit.edu	37	11	92613995	92613995	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr11:92613995G>A	ENST00000298047.6	+	22	12243	c.12226G>A	c.(12226-12228)Gat>Aat	p.D4076N	FAT3_ENST00000525166.1_Missense_Mutation_p.D3926N|FAT3_ENST00000533797.1_Missense_Mutation_p.D411N|FAT3_ENST00000409404.2_Missense_Mutation_p.D4076N			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4076	EGF-like 3.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGGATCCTGCGATCCAATAGG	0.453000										TCGA Ovarian(4;0.039)			15	214					0	0	0.500413	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	60					0	0	0.115264	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20128845	20128845	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr22:20128845C>T	ENST00000334554.7	+	8	1141	c.1000C>T	c.(1000-1002)Cgc>Tgc	p.R334C	ZDHHC8_ENST00000405930.3_Missense_Mutation_p.R334C|ZDHHC8_ENST00000320602.7_Missense_Mutation_p.R242C|ZDHHC8_ENST00000468112.1_3'UTR	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	334						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					GCAGACCCCGCGCCCAGGCAG	0.642000													3	39					0	0	0.150653	0	0
A2M	2	broad.mit.edu	37	12	9262615	9262615	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr12:9262615C>T	ENST00000318602.7	-	6	828	c.521G>A	c.(520-522)cGc>cAc	p.R174H		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	174					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding	p.R174H(1)		breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	TTGTGCGATGCGATTTCCTTT	0.423000													9	125					0	0	0.361761	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													4	65					0	0	0.150653	0	0
PLXNB1	5364	broad.mit.edu	37	3	48453984	48453984	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr3:48453984G>A	ENST00000358536.4	-	26	5169	c.4900C>T	c.(4900-4902)Cgt>Tgt	p.R1634C	PLXNB1_ENST00000448774.2_Missense_Mutation_p.R245C|PLXNB1_ENST00000456774.1_Missense_Mutation_p.R1451C|PLXNB1_ENST00000296440.6_Missense_Mutation_p.R1634C|PLXNB1_ENST00000358459.4_Missense_Mutation_p.R1451C	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1634					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACGTAGGCACGGTCCCGAGCT	0.587000													5	50					0	0	0.184627	0	0
UGT2B4	7363	broad.mit.edu	37	4	70355193	70355193	+	Silent	SNP	A	A	G			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr4:70355193A>G	ENST00000305107.6	-	3	1012	c.966T>C	c.(964-966)aaT>aaC	p.N322N	UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000512583.1_Silent_p.N322N|UGT2B4_ENST00000381096.3_Silent_p.N186N	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	322					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						ATGCAATTACATTGGCCCTTT	0.403000													9	205					0	0	0.307466	0	0
KRTAP9-9	81870	broad.mit.edu	37	17	39411940	39411940	+	Silent	SNP	C	C	T			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr17:39411940C>T	ENST00000394008.1	+	1	305	c.303C>T	c.(301-303)ggC>ggT	p.G101G		NM_030975.2	NP_112237.2	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	101						keratin filament				endometrium(3)|skin(2)|upper_aerodigestive_tract(1)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCAGCTGTGGCCAGAGCAGCT	0.617000													5	165					0	0	0.184627	0	0
ALPP	250	broad.mit.edu	37	2	233244593	233244593	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr2:233244593C>T	ENST00000392027.2	+	5	873	c.604C>T	c.(604-606)Cag>Tag	p.Q202*	AC068134.8_ENST00000441266.1_RNA|AC068134.8_ENST00000439072.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	202						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		CTCCGCCCGCCAGGAGGGGTG	0.672000													4	58					0	0	0.184627	0	0
SPOP	8405	broad.mit.edu	37	17	47696461	47696461	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr17:47696461C>T	ENST00000393331.3	-	7	832	c.362G>A	c.(361-363)cGg>cAg	p.R121Q	SPOP_ENST00000393328.2_Missense_Mutation_p.R121Q|SPOP_ENST00000347630.2_Missense_Mutation_p.R121Q|SPOP_ENST00000503676.1_Missense_Mutation_p.R121Q|SPOP_ENST00000504102.1_Missense_Mutation_p.R121Q	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	121	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.R121Q(1)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						CCTATATGCCCGTTGACTCTC	0.433000										Prostate(2;0.17)			6	159					0	0	0.217242	0	0
PECR	55825	broad.mit.edu	37	2	216931198	216931198	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr2:216931198C>G	ENST00000265322.7	-	2	242	c.168G>C	c.(166-168)aaG>aaC	p.K56N	PECR_ENST00000497889.1_5'UTR	NM_018441.5	NP_060911.2	Q9BY49	PECR_HUMAN	peroxisomal trans-2-enoyl-CoA reductase	56					fatty acid biosynthetic process|regulation of apoptosis	peroxisome	binding|trans-2-enoyl-CoA reductase (NADPH) activity			endometrium(2)|kidney(1)|liver(1)|lung(9)|stomach(1)	14		Renal(323;0.0327)		Epithelial(149;3.8e-06)|all cancers(144;0.000272)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Adenine(DB00173)	CTGCCGCAGACTTCAATCTCT	0.488000													4	110					0	0	0.150653	0	0
ATP1A4	480	broad.mit.edu	37	1	160147371	160147371	+	Silent	SNP	A	A	C			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr1:160147371A>C	ENST00000368081.4	+	18	3124	c.2653A>C	c.(2653-2655)Agg>Cgg	p.R885R	ATP1A4_ENST00000470705.1_Silent_p.R21R|ATP1A4_ENST00000418334.1_3'UTR	NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	885					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GAATGGTTTTAGGCCTGTTGA	0.507000													4	98					0	0	0.150653	0	0
PCSK9	255738	broad.mit.edu	37	1	55505552	55505553	+	In_Frame_Ins	INS	-	-	CTG	rs35574083		TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr1:55505552_55505553insCTG	ENST00000302118.5	+	1	332_333	c.42_43insCTG	c.(40-45)cctgct>ccCTGtgct	p.14_15PA>PCA	PCSK9_ENST00000452118.2_In_Frame_Ins_p.14_15PA>PCA	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	14					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding	p.P14_L15insL(2)		NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						Ggccgctgccactgctgctgct	0.703													3	3	---	---	---	---					
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121116645	121116645	+	RNA	DEL	T	T	-			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr1:121116645delT	ENST00000437515.1	-	0	329																											CAAGCCCCCCTTTAAAAAAAA	0.393													7	62	---	---	---	---					
ZNF268	10795	broad.mit.edu	37	12	133779606	133779606	+	Frame_Shift_Del	DEL	T	T	-			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr12:133779606delT	ENST00000536435.2	+	6	1664	c.1334delT	c.(1333-1335)gtfs	p.V445fs	ZNF268_ENST00000541009.2_3'UTR|ZNF268_ENST00000228289.5_Frame_Shift_Del_p.V445fs|ZNF268_ENST00000536899.2_3'UTR|ZNF268_ENST00000537565.1_Frame_Shift_Del_p.V284fs|ZNF268_ENST00000542986.2_3'UTR	NM_001165885.1|NM_003415.2	NP_001159357.1|NP_003406.1	Q14587	ZN268_HUMAN	zinc finger protein 268	445						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(3)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(1)	24	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.000215)|all_epithelial(31;0.096)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		AAACCTTATGTTTGTAGTGAT	0.408													2	4	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													4	8	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	-	G	rs2981599		TCGA-75-7030-01A-11D-1945-08	TCGA-75-7030-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0ce6f3ed-bdbc-4b70-9db4-2e48f4bf644d	9659d703-504e-4b47-a4f4-b376dbbbfbac	g.chr16:3119304_3119305insG	ENST00000525643.2	+	7	847_848	c.515_516insG	c.(514-516)gaafs	p.E172fs	IL32_ENST00000534507.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000396887.3_Frame_Shift_Ins_p.E115fs|IL32_ENST00000551513.1_Frame_Shift_Ins_p.E209fs|IL32_ENST00000325568.5_Frame_Shift_Ins_p.E172fs|IL32_ENST00000528163.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000551122.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000529699.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000396890.2_Frame_Shift_Ins_p.E218fs|IL32_ENST00000549213.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000530538.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000440815.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000552936.1_Frame_Shift_Ins_p.E196fs|IL32_ENST00000548246.1_Frame_Shift_Ins_p.E132fs|IL32_ENST00000382213.3_Frame_Shift_Ins_p.E163fs|IL32_ENST00000008180.9_Frame_Shift_Ins_p.E152fs|IL32_ENST00000529550.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000552664.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000533097.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000548476.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000444393.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000526464.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000548652.1_Frame_Shift_Ins_p.E163fs|IL32_ENST00000530890.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000531965.1_Frame_Shift_Ins_p.E162fs|IL32_ENST00000552356.1_Frame_Shift_Ins_p.E152fs			P24001	IL32_HUMAN	interleukin 32	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						CCACGGGGGGACAAGGAGGAGC	0.574													8	301	---	---	---	---