Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IGKV6D-41	28869	broad.mit.edu	37	2	90108951	90108951	+	RNA	SNP	C	C	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr2:90108951C>G	ENST00000390271.2	+	0	242																											AGTATGCTTCCCAGTCCATCT	0.517000													10	96					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038777	75038777	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr1:75038777C>G	ENST00000326665.5	-	14	2835	c.2617G>C	c.(2617-2619)Gat>Cat	p.D873H	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	873	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GGAGCCTCATCTTTACTCAGA	0.527000													77	164					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27296911	27296911	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr8:27296911G>T	ENST00000397501.1	+	25	2638	c.1830G>T	c.(1828-1830)atG>atT	p.M610I	PTK2B_ENST00000517339.1_Missense_Mutation_p.M610I|PTK2B_ENST00000338238.4_Missense_Mutation_p.M610I|PTK2B_ENST00000544172.1_Missense_Mutation_p.M610I|PTK2B_ENST00000420218.2_Missense_Mutation_p.M610I|PTK2B_ENST00000397497.4_Missense_Mutation_p.M356I|PTK2B_ENST00000346049.5_Missense_Mutation_p.M610I	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	610	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		ACGTCTGGATGTTCGGTGAGT	0.552000													9	45					0.0135373	0.0138715	1	1	0
MYO1G	64005	broad.mit.edu	37	7	45014808	45014808	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr7:45014808G>A	ENST00000258787.7	-	5	719	c.583C>T	c.(583-585)Cac>Tac	p.H195Y		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	195	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						TCACCCACGTGCTGCTTGAGG	0.592000													64	646					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71492074	71492074	+	Silent	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr5:71492074G>A	ENST00000296755.7	+	5	3190	c.2892G>A	c.(2890-2892)gtG>gtA	p.V964V		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	964						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		ACGTATGTGTGAGCGCCTCCA	0.552000													10	28					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151259298	151259298	+	Silent	SNP	G	G	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr1:151259298G>T	ENST00000368879.2	+	2	629	c.531G>T	c.(529-531)ctG>ctT	p.L177L		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	177	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CAGATCCGCTGCCTCCCTCTG	0.617000													6	99					4.68919e-08	5.12109e-08	1	1	0
PROSER1	80209	broad.mit.edu	37	13	39588005	39588005	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr13:39588005G>A	ENST00000352251.3	-	11	2217	c.1384C>T	c.(1384-1386)Ctt>Ttt	p.L462F	PROSER1_ENST00000484434.2_Intron|PROSER1_ENST00000350125.3_Missense_Mutation_p.L440F	NM_025138.3	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	462	Ser-rich.																TTCACACCAAGTGGACCGGCA	0.493000													22	42					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144994957	144994957	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr8:144994957G>C	ENST00000322810.4	-	32	9612	c.9443C>G	c.(9442-9444)gCc>gGc	p.A3148G	PLEC_ENST00000356346.3_Missense_Mutation_p.A2997G|PLEC_ENST00000527096.1_Missense_Mutation_p.A3034G|PLEC_ENST00000354958.2_Missense_Mutation_p.A2989G|PLEC_ENST00000398774.2_Missense_Mutation_p.A2979G|PLEC_ENST00000354589.3_Missense_Mutation_p.A3011G|PLEC_ENST00000436759.2_Missense_Mutation_p.A3038G|PLEC_ENST00000357649.2_Missense_Mutation_p.A3015G|PLEC_ENST00000345136.3_Missense_Mutation_p.A3011G	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3148	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GTCCACCTCGGCTACGTCTCG	0.667000													17	52					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834848	125834848	+	Silent	SNP	C	C	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr12:125834848C>G	ENST00000299308.3	+	2	911	c.903C>G	c.(901-903)gtC>gtG	p.V301V		NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	301						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCTTTTTGGTCTCTCTGACCA	0.502000													27	336					0	0	1	0	0
LRP2BP	55805	broad.mit.edu	37	4	186294019	186294019	+	Missense_Mutation	SNP	A	A	C			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr4:186294019A>C	ENST00000362004.3	-	6	1611	c.800T>G	c.(799-801)tTt>tGt	p.F267C	LRP2BP_ENST00000328559.7_Missense_Mutation_p.F265C|RP11-714G18.1_ENST00000514884.1_RNA|LRP2BP_ENST00000505916.1_Missense_Mutation_p.F265C|LRP2BP_ENST00000510776.1_Missense_Mutation_p.F239C			Q9P2M1	LR2BP_HUMAN	LRP2 binding protein	265						cytoplasm	protein binding			breast(1)|endometrium(2)|large_intestine(6)|lung(3)|prostate(1)|skin(2)	15		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;2.14e-25)|Epithelial(43;1.55e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-11)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000766)|Colorectal(24;0.00116)|LUSC - Lung squamous cell carcinoma(40;0.00904)|COAD - Colon adenocarcinoma(29;0.0101)|READ - Rectum adenocarcinoma(43;0.161)		CCTTTTGGAAAATGCAACACA	0.373000													6	62					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16008253	16008253	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr19:16008253G>C	ENST00000221700.5	-	2	264	c.169C>G	c.(169-171)Cgg>Ggg	p.R57G	CYP4F2_ENST00000592328.1_Missense_Mutation_p.R57G|CYP4F2_ENST00000011989.7_5'UTR	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	57					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						AACCAGTTCCGTCTTGGGGGT	0.617000													11	131					0	0	1	0	0
MRPL38	64978	broad.mit.edu	37	17	73895713	73895713	+	Silent	SNP	C	C	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr17:73895713C>T	ENST00000309352.3	-	7	1290	c.753G>A	c.(751-753)acG>acA	p.T251T	MRPL38_ENST00000409963.3_Silent_p.T67T|RP11-552F3.10_ENST00000587267.1_RNA	NM_032478.3	NP_115867.2	Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38	251						actin cytoskeleton|mitochondrion|ribosome				ovary(1)|pancreas(1)|prostate(2)|skin(1)	5			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGTAGGGACACGTCACCTGTC	0.617000													10	29					0	0	1	0	0
GPR37	2861	broad.mit.edu	37	7	124386617	124386617	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr7:124386617C>T	ENST00000303921.2	-	2	2454	c.1804G>A	c.(1804-1806)Gaa>Aaa	p.E602K		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	602						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GTGGACATTTCACGGCGTATG	0.433000													25	233					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1259365	1259365	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr16:1259365G>A	ENST00000348261.5	+	17	3945	c.3697G>A	c.(3697-3699)Gac>Aac	p.D1233N	CACNA1H_ENST00000565831.1_Missense_Mutation_p.D1233N|CACNA1H_ENST00000358590.4_Missense_Mutation_p.D1233N	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1233					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CCTGCGCATCGACAGCCACCG	0.716000													9	77					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9048402	9048402	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr19:9048402G>T	ENST00000397910.4	-	5	33432	c.33229C>A	c.(33229-33231)Cat>Aat	p.H11077N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11079	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTGCCCCATGACTGGTGGCC	0.507000													11	96					9.31168e-06	9.90858e-06	1	1	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr7:55259515T>G	ENST00000275493.2	+	21	2750	c.2573T>G	c.(2572-2574)cTg>cGg	p.L858R	EGFR_ENST00000442591.1_Intron|EGFR_ENST00000454757.2_Missense_Mutation_p.L805R|EGFR_ENST00000455089.1_Missense_Mutation_p.L813R	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	858	Protein kinase.		L -> M (found in a lung cancer sample).|L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(1489)|p.L858Q(1)|p.L858K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537000	L858R(NCIH1975_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			291	118					0	0	1	0	0
TRBV7-1	28597	broad.mit.edu	37	7	142032050	142032050	+	RNA	SNP	G	G	C			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr7:142032050G>C	ENST00000547918.2	+	0	45																											TGGGCACAAGGCTCCTCTGCT	0.562000													3	51					0	0	1	0	0
ZNF649	65251	broad.mit.edu	37	19	52394871	52394871	+	Missense_Mutation	SNP	T	T	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr19:52394871T>G	ENST00000354957.3	-	5	802	c.518A>C	c.(517-519)aAc>aCc	p.N173T	ZNF649_ENST00000600738.1_Missense_Mutation_p.N173T|CTC-429C10.2_ENST00000600329.1_RNA	NM_023074.3	NP_075562.2	Q9BS31	ZN649_HUMAN	zinc finger protein 649	173					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		TTTCTCTATGTTGTGTGTTTG	0.413000													30	258					0	0	1	0	0
TMEM189	387521	broad.mit.edu	37	20	48744620	48744620	+	Silent	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr20:48744620G>A	ENST00000557021.1	-	5	743	c.583C>T	c.(583-585)Ctg>Ttg	p.L195L	TMEM189_ENST00000371650.5_Silent_p.L192L|TMEM189_ENST00000371652.4_Silent_p.L195L|TMEM189-UBE2V1_ENST00000341698.2_Silent_p.L195L|TMEM189_ENST00000371656.2_Silent_p.L120L	NM_199203.2	NP_954673.1			transmembrane protein 189											breast(1)|endometrium(2)|large_intestine(3)|lung(2)	8			BRCA - Breast invasive adenocarcinoma(9;3.02e-07)			CAGCGTGGCAGCCCAAAGTAC	0.577000													3	94					0	0	1	0	0
RPL14	9045	broad.mit.edu	37	3	40502966	40502966	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr3:40502966G>A	ENST00000396203.2	+	4	401	c.269G>A	c.(268-270)cGa>cAa	p.R90Q	RPL14_ENST00000416518.1_Missense_Mutation_p.R90Q|RPL14_ENST00000338970.6_Missense_Mutation_p.R90Q	NM_001034996.2	NP_001030168.1	P50914	RL14_HUMAN	ribosomal protein L14	90					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome								KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GCAGCCACACGATGGGCCAAG	0.458000													5	48					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102514197	102514197	+	Silent	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr14:102514197G>A	ENST00000360184.4	+	73	13214	c.13050G>A	c.(13048-13050)gaG>gaA	p.E4350E	RP11-1017G21.4_ENST00000557242.1_RNA|RP11-1017G21.4_ENST00000553701.1_RNA	NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	4350					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						AGATGTTGGAGGATGAGGACG	0.592000													3	94					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75156810	75156810	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr8:75156810G>A	ENST00000342232.4	-	4	1899	c.1859C>T	c.(1858-1860)cCa>cTa	p.P620L	JPH1_ENST00000518195.1_5'UTR	NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	620					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			GTTGCTTGCTGGATTCTTTGG	0.418000													32	103					0	0	1	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27765086	27765086	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chrX:27765086A>T	ENST00000451261.2	+	5	473	c.74A>T	c.(73-75)gAg>gTg	p.E25V		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						AGCCCAGAGGAGCAGTCTGGA	0.557000													3	7					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179403878	179403878	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr2:179403878T>A	ENST00000589042.1	-	353	99008	c.98784A>T	c.(98782-98784)agA>agT	p.R32928S	TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R31287S|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R23988S|TTN_ENST00000460472.2_Missense_Mutation_p.R23863S|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R30360S|TTN_ENST00000342175.6_Missense_Mutation_p.R24055S|TTN-AS1_ENST00000590040.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	31287							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCCTGTGACTCTAGAACCAC	0.498000													7	90					0	0	1	0	0
PTK2B	2185	broad.mit.edu	37	8	27296909	27296909	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr8:27296909A>T	ENST00000397501.1	+	25	2636	c.1828A>T	c.(1828-1830)Atg>Ttg	p.M610L	PTK2B_ENST00000517339.1_Missense_Mutation_p.M610L|PTK2B_ENST00000338238.4_Missense_Mutation_p.M610L|PTK2B_ENST00000544172.1_Missense_Mutation_p.M610L|PTK2B_ENST00000420218.2_Missense_Mutation_p.M610L|PTK2B_ENST00000397497.4_Missense_Mutation_p.M356L|PTK2B_ENST00000346049.5_Missense_Mutation_p.M610L	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	610	Protein kinase.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		TGACGTCTGGATGTTCGGTGA	0.547000													9	45					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													6	141					0	0	1	0	0
GDF2	2658	broad.mit.edu	37	10	48414310	48414310	+	Silent	SNP	T	T	C			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr10:48414310T>C	ENST00000249598.1	-	2	717	c.558A>G	c.(556-558)acA>acG	p.T186T		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	186					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						TCTTGGTCTCTGTAGCACTAT	0.547000													3	40					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66083663	66083663	+	Missense_Mutation	SNP	G	G	A	rs138260039		TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr11:66083663G>A	ENST00000311330.3	-	1	852	c.836C>T	c.(835-837)cCg>cTg	p.P279L	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	279						integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	CTGCTCGCACGGAGCCTGGGC	0.677000													3	36					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189864281	189864281	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr2:189864281G>A	ENST00000304636.3	+	31	2377	c.2207G>A	c.(2206-2208)aGt>aAt	p.S736N	COL3A1_ENST00000317840.5_Missense_Mutation_p.S736N	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	736	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGTCTTGGAAGTCCTGGTCCA	0.463000													12	87					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47250579	47250579	+	Missense_Mutation	SNP	C	C	T	rs144064667	byFrequency	TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr2:47250579C>T	ENST00000319190.5	+	13	1911	c.1543C>T	c.(1543-1545)Cgg>Tgg	p.R515W	TTC7A_ENST00000461601.1_3'UTR|TTC7A_ENST00000409245.1_Missense_Mutation_p.R481W|TTC7A_ENST00000263737.6_Missense_Mutation_p.R161W|TTC7A_ENST00000394850.2_Missense_Mutation_p.R515W	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	515							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TGAATTGCACCGGAAGGCACT	0.597000													15	52					0	0	1	0	0
TRIM21	6737	broad.mit.edu	37	11	4410931	4410931	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr11:4410931C>T	ENST00000254436.7	-	3	569	c.457G>A	c.(457-459)Gct>Act	p.A153T	TRIM21_ENST00000543625.1_Missense_Mutation_p.A153T	NM_003141.3	NP_003132.2	P19474	RO52_HUMAN	tripartite motif containing 21	153					cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)	16		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		AACTTCTCAGCCAACTCCTGC	0.493000													5	214					0	0	1	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140865302	140865302	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr5:140865302G>A	ENST00000306593.1	+	1	562	c.562G>A	c.(562-564)Ggc>Agc	p.G188S	PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1												p.G188S(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCAGCGACGGCAGCCTGGT	0.567000													6	58					0	0	1	0	0
OR10P1	121130	broad.mit.edu	37	12	56030844	56030844	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr12:56030844T>A	ENST00000309675.2	+	1	201	c.169T>A	c.(169-171)Tcc>Acc	p.S57T		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						TGCCCTGCACTCCCCCATGTA	0.612000													6	142					0	0	1	0	0
MAN2A2	4122	broad.mit.edu	37	15	91453343	91453343	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr15:91453343C>G	ENST00000360468.3	+	9	1416	c.1398C>G	c.(1396-1398)gaC>gaG	p.D466E	MAN2A2_ENST00000559717.1_Missense_Mutation_p.D466E|MAN2A2_ENST00000431652.2_Intron	NM_006122.2	NP_006113.2	P49641	MA2A2_HUMAN	mannosidase, alpha, class 2A, member 2	466					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			CTCTTTCTGACTATTTTGATG	0.582000													6	131					0	0	1	0	0
FAM86HP	729375	broad.mit.edu	37	3	129821632	129821632	+	RNA	SNP	C	C	T	rs115468595	by1000genomes	TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr3:129821632C>T	ENST00000500074.2	-	0	513																											ACACCTGGCACGTCTCTGGGT	0.662000													6	175					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179729428	179729428	+	Missense_Mutation	SNP	A	A	C			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr5:179729428A>C	ENST00000253778.8	-	18	2168	c.1999T>G	c.(1999-2001)Tat>Gat	p.Y667D		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	667	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	CGCACGTCATATCCTCGGAGA	0.498000													3	114					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	132069983	132069983	+	Silent	SNP	A	A	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr7:132069983A>T	ENST00000423507.2	-	4	1577	c.1443T>A	c.(1441-1443)acT>acA	p.T481T	PLXNA4_ENST00000321063.4_Intron|PLXNA4_ENST00000359827.3_Intron	NM_001105543.1	NP_001099013.1	Q9HCM2	PLXA4_HUMAN	plexin A4	1029	Sema.					integral to membrane|intracellular|plasma membrane		p.T481T(1)		NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GGAGTTCCAGAGTCACTGTTG	0.478000													6	70					0	0	1	0	0
KAT7	11143	broad.mit.edu	37	17	47904072	47904072	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr17:47904072G>T	ENST00000503935.2	+	14	2213	c.1177G>T	c.(1177-1179)Gct>Tct	p.A393S	KAT7_ENST00000435742.2_Missense_Mutation_p.A363S|KAT7_ENST00000510819.1_Missense_Mutation_p.A380S|KAT7_ENST00000259021.4_Missense_Mutation_p.A549S|KAT7_ENST00000509773.1_Missense_Mutation_p.A439S|KAT7_ENST00000513980.1_3'UTR|KAT7_ENST00000424009.2_Missense_Mutation_p.A519S|KAT7_ENST00000454930.2_Missense_Mutation_p.A410S			O95251	MYST2_HUMAN	K(lysine) acetyltransferase 7	549					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding										TCAGGAGACGGCTGTGAATCC	0.478000													12	162					1.99824e-07	2.15394e-07	1	1	0
TMPRSS6	164656	broad.mit.edu	37	22	37482363	37482363	+	Silent	SNP	G	G	A	rs141319169	byFrequency	TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr22:37482363G>A	ENST00000381792.2	-	8	1073	c.933C>T	c.(931-933)taC>taT	p.Y311Y	TMPRSS6_ENST00000442782.2_Silent_p.Y320Y|TMPRSS6_ENST00000406725.1_Silent_p.Y311Y|TMPRSS6_ENST00000406856.1_Silent_p.Y311Y|TMPRSS6_ENST00000346753.3_Silent_p.Y320Y			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	320	CUB 1.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity	p.Y320Y(1)		breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						CGAAGGGGTCGTAGTAGCTGT	0.677000													10	38					0	0	1	0	0
CCDC36	339834	broad.mit.edu	37	3	49293879	49293879	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr3:49293879G>T	ENST00000438782.1	+	8	1185	c.949G>T	c.(949-951)Gaa>Taa	p.E317*	CCDC36_ENST00000296449.5_Nonsense_Mutation_p.E317*|CCDC36_ENST00000452691.2_Nonsense_Mutation_p.E317*			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	317										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		ACAGCCTGGAGAATTTGATGT	0.507000													5	82					1.23904e-05	1.30178e-05	1	1	0
ZFYVE16	9765	broad.mit.edu	37	5	79746335	79746335	+	Silent	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr5:79746335G>A	ENST00000338008.5	+	9	3492	c.3312G>A	c.(3310-3312)ttG>ttA	p.L1104L	ZFYVE16_ENST00000505560.1_Silent_p.L1104L|ZFYVE16_ENST00000510158.1_Silent_p.L1104L	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	1104					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TGTTATGTTTGCCAAATGAAG	0.333000													24	136					0	0	1	0	0
ZFPM1	161882	broad.mit.edu	37	16	88599208	88599208	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr16:88599208A>G	ENST00000319555.3	+	9	1376	c.1054A>G	c.(1054-1056)Agc>Ggc	p.S352G		NM_153813.2	NP_722520.2	Q8IX07	FOG1_HUMAN	zinc finger protein, FOG family member 1	352					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)|ovary(2)|urinary_tract(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TGTCTGCCACAGCTGTGGCTT	0.657000													12	88					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38427311	38427311	+	Missense_Mutation	SNP	G	G	A	rs147520523	byFrequency	TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr5:38427311G>A	ENST00000322350.5	+	14	2357	c.2011G>A	c.(2011-2013)Gtg>Atg	p.V671M	EGFLAM_ENST00000354891.3_Missense_Mutation_p.V671M|EGFLAM_ENST00000336740.6_Missense_Mutation_p.V437M|EGFLAM_ENST00000397202.2_Missense_Mutation_p.V37M|EGFLAM-AS1_ENST00000508986.1_RNA	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	671	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					AGGGGGCCACGTGGAGTTCCG	0.522000													40	286					0	0	1	0	0
CHGA	1113	broad.mit.edu	37	14	93397926	93397926	+	Silent	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr14:93397926G>A	ENST00000216492.5	+	6	967	c.687G>A	c.(685-687)gaG>gaA	p.E229E	CHGA_ENST00000553866.1_3'UTR|CHGA_ENST00000334654.4_Intron	NM_001275.3	NP_001266.1	P10645	CMGA_HUMAN	chromogranin A (parathyroid secretory protein 1)	229					regulation of blood pressure	extracellular region|stored secretory granule				cervix(1)|large_intestine(1)|lung(3)|skin(3)	8		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		AGAGAgaagaggaggaggagg	0.647000													3	42					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000392221.1_Silent_p.P45P|EEF1B2_ENST00000236957.5_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													6	148					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414379	20414379	+	Silent	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr9:20414379G>A	ENST00000380338.4	-	5	751	c.465C>T	c.(463-465)agC>agT	p.S155S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S152S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	155	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S155S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.532000			T	MLL	ALL								4	15					0	0	1	0	0
SNAI3	333929	broad.mit.edu	37	16	88744934	88744934	+	Silent	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr16:88744934G>A	ENST00000332281.5	-	3	887	c.801C>T	c.(799-801)tgC>tgT	p.C267C	SNAI3-AS1_ENST00000563261.1_RNA	NM_178310.3	NP_840101.1	Q3KNW1	SNAI3_HUMAN	snail family zinc finger 3	267					oxidation-reduction process		copper ion binding|DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|kidney(1)|lung(1)|ovary(1)|skin(1)	6				BRCA - Breast invasive adenocarcinoma(80;0.048)		TGCAGCGCCGGCACCGGTACT	0.667000													3	46					0	0	1	0	0
MAS1L	116511	broad.mit.edu	37	6	29455331	29455331	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr6:29455331C>T	ENST00000377127.3	-	1	407	c.349G>A	c.(349-351)Gct>Act	p.A117T		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	117						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						ACGTCAGCAGCGACCAGGTGG	0.517000													4	70					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18622538	18622538	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr18:18622538C>T	ENST00000399799.1	-	7	1748	c.808G>A	c.(808-810)Gaa>Aaa	p.E270K		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	270	Protein kinase.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					ACAAGCATTTCGTATAAAAAT	0.348000													89	148					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578443	7578443	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr17:7578443A>G	ENST00000420246.2	-	5	619	c.487T>C	c.(487-489)Tac>Cac	p.Y163H	TP53_ENST00000269305.4_Missense_Mutation_p.Y163H|TP53_ENST00000413465.2_Missense_Mutation_p.Y163H|TP53_ENST00000359597.4_Missense_Mutation_p.Y163H|TP53_ENST00000445888.2_Missense_Mutation_p.Y163H|TP53_ENST00000455263.2_Missense_Mutation_p.Y163H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	163	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y163N(20)|p.Y163H(17)|p.0?(8)|p.Y163D(5)|p.I162_Y163>N(3)|p.Y163fs*7(2)|p.V157_C176del20(1)|p.Y163fs*1(1)|p.Y163_Q165delYKQ(1)|p.P151_V173del23(1)|p.S149fs*72(1)|p.I30_Y31>N(1)|p.I162_Y163delIY(1)|p.I69_Y70>N(1)|p.Y70N(1)|p.A161fs*7(1)|p.Y31N(1)|p.Y163fs*14(1)|p.A159_Q167delAMAIYKQSQ(1)|p.Y163fs*18(1)|p.Y70D(1)|p.Y31D(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GACTGCTTGTAGATGGCCATG	0.622000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			21	65					0	0	1	0	0
MIR522	574495	broad.mit.edu	37	19	54254543	54254543	+	RNA	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr19:54254543G>A	ENST00000385071.1	+	0	79					NR_030217.1																						AGAGTGTTACGCTTTGAGAAA	0.418000													15	53					0	0	1	0	0
TTC24	164118	broad.mit.edu	37	1	156555578	156555578	+	Silent	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr1:156555578G>A	ENST00000368236.3	+	9	1566	c.1530G>A	c.(1528-1530)acG>acA	p.T510T	TTC24_ENST00000495690.1_3'UTR|TTC24_ENST00000368237.3_Silent_p.T510T	NM_001105669.2	NP_001099139.2	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	510							binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|prostate(1)	20	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCAAGCACACGCCCTGCAGAG	0.517000													8	181					0	0	1	0	0
FBXO17	115290	broad.mit.edu	37	19	39435614	39435614	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr19:39435614G>A	ENST00000292852.4	-	5	1029	c.688C>T	c.(688-690)Cga>Tga	p.R230*	CTC-360G5.8_ENST00000599996.1_Missense_Mutation_p.P134L|FBXO17_ENST00000595329.1_Nonsense_Mutation_p.R230*|SARS2_ENST00000448145.2_Nonsense_Mutation_p.R65*	NM_024907.5	NP_079183.4			F-box protein 17											breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)	7	all_cancers(60;8.37e-07)|all_lung(34;3.71e-07)|Lung NSC(34;4.17e-07)|all_epithelial(25;1.13e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CCCACCTGTCGGCAGCCCCTC	0.602000													13	111					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99662889	99662889	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chrX:99662889G>A	ENST00000373034.4	-	1	2382	c.707C>T	c.(706-708)cCg>cTg	p.P236L	PCDH19_ENST00000255531.7_Missense_Mutation_p.P236L|PCDH19_ENST00000420881.2_Missense_Mutation_p.P236L	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	236	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						GCTAAACACCGGGTTGTTGTC	0.617000													5	130					0	0	1	0	0
FLAD1	80308	broad.mit.edu	37	1	154962054	154962054	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr1:154962054A>G	ENST00000368433.1	+	3	1479	c.1136A>G	c.(1135-1137)aAg>aGg	p.K379R	FLAD1_ENST00000295530.2_Intron|FLAD1_ENST00000405236.2_Intron|FLAD1_ENST00000368428.1_5'UTR|FLAD1_ENST00000368432.1_Missense_Mutation_p.K282R|FLAD1_ENST00000292180.3_Missense_Mutation_p.K379R|FLAD1_ENST00000315144.10_Missense_Mutation_p.K282R			Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	379					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTGGGGAAAAAGGTGGCAGGT	0.567000													4	155					0	0	1	0	0
VRK3	51231	broad.mit.edu	37	19	50500778	50500778	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr19:50500778G>A	ENST00000599538.1	-	7	1326	c.662C>T	c.(661-663)gCc>gTc	p.A221V	VRK3_ENST00000601912.1_Missense_Mutation_p.A171V|VRK3_ENST00000377011.2_Missense_Mutation_p.A171V|VRK3_ENST00000594948.1_Missense_Mutation_p.A221V|VRK3_ENST00000593919.1_Missense_Mutation_p.A221V|VRK3_ENST00000601341.1_Missense_Mutation_p.A171V|VRK3_ENST00000443401.2_Intron|VRK3_ENST00000424804.2_Intron|VRK3_ENST00000594092.1_Missense_Mutation_p.A221V|VRK3_ENST00000316763.3_Missense_Mutation_p.A221V			Q8IV63	VRK3_HUMAN	vaccinia related kinase 3	221	Protein kinase.					nucleus	ATP binding|protein kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)|stomach(2)|urinary_tract(1)	23		all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00166)|OV - Ovarian serous cystadenocarcinoma(262;0.00652)		AGGCTTGGCGGCCCGCTGGAA	0.587000													4	57					0	0	1	0	0
FGF18	8817	broad.mit.edu	37	5	170863216	170863216	+	Silent	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr5:170863216G>A	ENST00000274625.5	+	3	733	c.189G>A	c.(187-189)ggG>ggA	p.G63G		NM_003862.2	NP_003853.1	O76093	FGF18_HUMAN	fibroblast growth factor 18	63					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	9	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GGACCAGTGGGAAACACATCC	0.627000													7	58					0	0	1	0	0
PACSIN2	11252	broad.mit.edu	37	22	43289489	43289489	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr22:43289489C>T	ENST00000263246.3	-	3	392	c.191G>A	c.(190-192)cGg>cAg	p.R64Q	PACSIN2_ENST00000496919.1_5'UTR|PACSIN2_ENST00000402229.1_Missense_Mutation_p.R64Q|PACSIN2_ENST00000407585.1_Missense_Mutation_p.R64Q|PACSIN2_ENST00000337959.4_Missense_Mutation_p.R64Q|PACSIN2_ENST00000403744.3_Missense_Mutation_p.R64Q	NM_001184970.1	NP_001171899.1	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in neurons 2	64	FCH.				actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)	19		Glioma(61;0.222)				CCTCCAGCGCCGGGCCCACTC	0.672000													15	67					0	0	1	0	0
DDX53	168400	broad.mit.edu	37	X	23019710	23019710	+	Silent	SNP	C	C	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chrX:23019710C>T	ENST00000327968.5	+	1	1624	c.1536C>T	c.(1534-1536)gaC>gaT	p.D512D	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	512	Helicase C-terminal.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						CAGTAGAGGACTTTAAAAGCG	0.378000													24	46					0	0	1	0	0
ANKRA2	57763	broad.mit.edu	37	5	72858614	72858614	+	Missense_Mutation	SNP	T	T	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr5:72858614T>G	ENST00000296785.3	-	2	751	c.93A>C	c.(91-93)aaA>aaC	p.K31N		NM_023039.4	NP_075526.1	Q9H9E1	ANRA2_HUMAN	ankyrin repeat, family A (RFXANK-like), 2	31						cytoskeleton|cytosol|membrane	low-density lipoprotein particle binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8		Lung NSC(167;0.0378)|Ovarian(174;0.0908)		OV - Ovarian serous cystadenocarcinoma(47;3.71e-54)		GATGTTCTATTTTAATGTCTG	0.423000													11	174					0	0	1	0	0
FGF18	8817	broad.mit.edu	37	5	170863180	170863180	+	Silent	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr5:170863180G>A	ENST00000274625.5	+	3	697	c.153G>A	c.(151-153)caG>caA	p.Q51Q		NM_003862.2	NP_003853.1	O76093	FGF18_HUMAN	fibroblast growth factor 18	51					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	9	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCCGTAAGCAGCTGCGGCTGT	0.627000													6	67					0	0	1	0	0
PSMD13	5719	broad.mit.edu	37	11	250829	250829	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr11:250829G>C	ENST00000532097.1	+	10	1305	c.801G>C	c.(799-801)caG>caC	p.Q267H	PSMD13_ENST00000352303.5_Missense_Mutation_p.Q267H|PSMD13_ENST00000431206.2_Missense_Mutation_p.Q269H	NM_002817.3	NP_002808.3	Q9UNM6	PSD13_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	267	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding			NS(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	10		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.79e-27)|Epithelial(43;4e-26)|OV - Ovarian serous cystadenocarcinoma(40;6.02e-21)|BRCA - Breast invasive adenocarcinoma(625;3.93e-05)|Lung(200;0.112)|LUSC - Lung squamous cell carcinoma(625;0.129)		ATGAAGCCCAGCTTCTGAGGA	0.453000											OREG0020657	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	86					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358537	10358537	+	Silent	SNP	T	T	C			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr17:10358537T>C	ENST00000255381.2	-	20	2360	c.2250A>G	c.(2248-2250)ctA>ctG	p.L750L	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	750	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CAATAGACCCTAGAAGTTTCT	0.373000													3	71					0	0	1	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140890603	140890603	+	Missense_Mutation	SNP	G	G	A	rs116366286	by1000genomes	TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr5:140890603G>A	ENST00000252085.3	+	4	2804	c.2662G>A	c.(2662-2664)Gtg>Atg	p.V888M	PCDHGA8_ENST00000398604.2_Missense_Mutation_p.V888M|PCDHGA10_ENST00000398610.2_Missense_Mutation_p.V892M|PCDHGC3_ENST00000308177.3_Missense_Mutation_p.V890M|PCDHGC4_ENST00000306593.1_Missense_Mutation_p.V894M|PCDHGC5_ENST00000252087.1_Missense_Mutation_p.V900M|PCDHGB1_ENST00000523390.1_Missense_Mutation_p.V883M|PCDHGB3_ENST00000576222.1_Missense_Mutation_p.V885M|PCDHGB7_ENST00000398594.2_Missense_Mutation_p.V885M|PCDHGB2_ENST00000522605.1_Missense_Mutation_p.V887M|PCDHGA4_ENST00000571252.1_Missense_Mutation_p.V887M|PCDHGA7_ENST00000518325.1_Missense_Mutation_p.V888M|PCDHGA6_ENST00000517434.1_Missense_Mutation_p.V888M|PCDHGA11_ENST00000518882.1_Missense_Mutation_p.V706M|PCDHGA2_ENST00000394576.2_Missense_Mutation_p.V888M|PCDHGA3_ENST00000253812.6_Missense_Mutation_p.V888M|PCDHGA1_ENST00000517417.1_Missense_Mutation_p.V887M|PCDHGA9_ENST00000573521.1_Missense_Mutation_p.V888M|PCDHGB4_ENST00000519479.1_Missense_Mutation_p.V879M|PCDHGB6_ENST00000520790.1_Missense_Mutation_p.V886M|PCDHGA11_ENST00000398587.2_Missense_Mutation_p.V891M|PCDHGA5_ENST00000518069.1_Missense_Mutation_p.V887M	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGCAGCACGTGCCCGACTA	0.642000													14	182					0	0	1	0	0
MMP24	10893	broad.mit.edu	37	20	33851652	33851652	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr20:33851652C>G	ENST00000246186.6	+	5	961	c.876C>G	c.(874-876)caC>caG	p.H292Q	MMP24-AS1_ENST00000433764.1_RNA|MMP24-AS1_ENST00000453892.1_RNA|MMP24-AS1_ENST00000566203.1_RNA|EDEM2_ENST00000540582.1_Intron|MMP24-AS1_ENST00000456350.1_RNA|MMP24-AS1_ENST00000454184.1_RNA|MMP24-AS1_ENST00000438751.1_RNA	NM_006690.3	NP_006681.1	Q9Y5R2	MMP24_HUMAN	matrix metallopeptidase 24 (membrane-inserted)	292					proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(3)|large_intestine(1)|lung(2)|prostate(2)|skin(5)	14			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GACTGGAGCACTCCAGCGACC	0.622000													4	12					0	0	1	0	0
MAS1L	116511	broad.mit.edu	37	6	29455436	29455436	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr6:29455436C>G	ENST00000377127.3	-	1	302	c.244G>C	c.(244-246)Gct>Cct	p.A82P		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	82						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						ACCAGCACAGCCTTGGGGGCA	0.517000													13	32					0	0	1	0	0
KAT7	11143	broad.mit.edu	37	17	47904073	47904073	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr17:47904073C>T	ENST00000503935.2	+	14	2214	c.1178C>T	c.(1177-1179)gCt>gTt	p.A393V	KAT7_ENST00000435742.2_Missense_Mutation_p.A363V|KAT7_ENST00000510819.1_Missense_Mutation_p.A380V|KAT7_ENST00000259021.4_Missense_Mutation_p.A549V|KAT7_ENST00000509773.1_Missense_Mutation_p.A439V|KAT7_ENST00000513980.1_3'UTR|KAT7_ENST00000424009.2_Missense_Mutation_p.A519V|KAT7_ENST00000454930.2_Missense_Mutation_p.A410V			O95251	MYST2_HUMAN	K(lysine) acetyltransferase 7	549					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding										CAGGAGACGGCTGTGAATCCT	0.478000													12	164					0	0	1	0	0
PPIL3	53938	broad.mit.edu	37	2	201741737	201741737	+	Silent	SNP	A	A	C			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr2:201741737A>C	ENST00000286175.8	-	6	659	c.276T>G	c.(274-276)tcT>tcG	p.S92S	PPIL3_ENST00000409361.1_Silent_p.S84S|PPIL3_ENST00000409449.1_Silent_p.S92S|PPIL3_ENST00000392283.4_Silent_p.S88S|PPIL3_ENST00000465823.1_5'UTR	NM_032472.3	NP_115861.1	Q9H2H8	PPIL3_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 3	88	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity|protein binding			endometrium(1)|lung(2)	3						TATTAGCCATAGATACAACAC	0.378000													29	52					0	0	1	0	0
SGOL2	151246	broad.mit.edu	37	2	201437932	201437932	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr2:201437932C>A	ENST00000357799.4	+	7	2961	c.2863C>A	c.(2863-2865)Caa>Aaa	p.Q955K		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	955					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						ACTTGAATGCCAAGACATTAT	0.279000													3	54					1	1	1	1	0
UBA6	55236	broad.mit.edu	37	4	68529644	68529644	+	Missense_Mutation	SNP	T	T	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr4:68529644T>G	ENST00000322244.4	-	11	978	c.919A>C	c.(919-921)Aaa>Caa	p.K307Q	UBA6_ENST00000420827.2_Missense_Mutation_p.K307Q	NM_018227.5	NP_060697.4	A0AVT1	UBA6_HUMAN	ubiquitin-like modifier activating enzyme 6	307					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						TTTGGATGTTTTAACTGCCTC	0.393000													18	107					0	0	1	0	0
CIT	11113	broad.mit.edu	37	12	120128095	120128095	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr12:120128095C>T	ENST00000392521.2	-	47	6102	c.6047G>A	c.(6046-6048)cGc>cAc	p.R2016H	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Missense_Mutation_p.R1974H	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1974					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		CTCCAGGGGGCGGCCAGGAGA	0.731000													3	28					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103124113	103124113	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr11:103124113C>T	ENST00000375735.2	+	66	10286	c.10142C>T	c.(10141-10143)cCg>cTg	p.P3381L	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.P3388L	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3381	AAA 5 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTTATTCCACCGGATGCAGCT	0.368000													9	83					0	0	1	0	0
HTRA1	5654	broad.mit.edu	37	10	124268260	124268260	+	Missense_Mutation	SNP	C	C	T	rs139620409	byFrequency	TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr10:124268260C>T	ENST00000368984.3	+	6	1222	c.1094C>T	c.(1093-1095)aCg>aTg	p.T365M		NM_002775.4	NP_002766.1	Q92743	HTRA1_HUMAN	HtrA serine peptidase 1	365	PDZ.				proteolysis|regulation of cell growth	extracellular space	insulin-like growth factor binding|serine-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(8)|lung(7)	17		all_neural(114;0.0765)|Lung NSC(174;0.133)|all_lung(145;0.163)|Breast(234;0.238)				AAGTTCCTCACGGAGTCCCAT	0.522000													4	123					0	0	1	0	0
PRKCA	5578	broad.mit.edu	37	17	64641607	64641607	+	Silent	SNP	T	T	C			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr17:64641607T>C	ENST00000413366.3	+	5	533	c.507T>C	c.(505-507)gcT>gcC	p.A169A		NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	169					activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	CTGAGGTTGCTGATGAAAAGC	0.512000													4	129					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28991130	28991130	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr18:28991130G>A	ENST00000359747.4	+	14	2160	c.2131G>A	c.(2131-2133)Gtt>Att	p.V711I	RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Intron	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	699					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CGGCGGCAGCGTTTTAGGCAG	0.567000													4	29					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38858534	38858534	+	Silent	SNP	T	T	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr6:38858534T>G	ENST00000359357.3	+	56	8183	c.7929T>G	c.(7927-7929)acT>acG	p.T2643T	DNAH8_ENST00000449981.2_Silent_p.T2860T|DNAH8_ENST00000441566.1_Silent_p.T2607T					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GGCAATGGACTAAGGTACAGA	0.358000													32	69					0	0	1	0	0
SLC4A10	57282	broad.mit.edu	37	2	162361620	162361620	+	RNA	DEL	T	T	-			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr2:162361620delT	ENST00000605990.1	+	0	344																											TGAGGGCTTGTCTGTGCTCGC	0.433													12	56	---	---	---	---					
DYNC1I2	1781	broad.mit.edu	37	2	172546761	172546762	+	Frame_Shift_Ins	INS	-	-	A			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr2:172546761_172546762insA	ENST00000534253.2	+	2	264_265	c.96_97insA	c.(94-99)agaaaafs	p.RK32fs	DYNC1I2_ENST00000358002.6_Frame_Shift_Ins_p.RK32fs|DYNC1I2_ENST00000508530.1_Frame_Shift_Ins_p.RK32fs|DYNC1I2_ENST00000410079.3_Frame_Shift_Ins_p.RK32fs|DYNC1I2_ENST00000397119.3_Frame_Shift_Ins_p.RK32fs|DYNC1I2_ENST00000409453.1_Frame_Shift_Ins_p.RK32fs|DYNC1I2_ENST00000409317.1_Frame_Shift_Ins_p.RK32fs|DYNC1I2_ENST00000409773.1_Frame_Shift_Ins_p.RK32fs|DYNC1I2_ENST00000409197.1_Frame_Shift_Ins_p.RK32fs|DYNC1I2_ENST00000263811.4_Frame_Shift_Ins_p.RK32fs|DYNC1I2_ENST00000340296.4_Frame_Shift_Ins_p.RK32fs			Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	32					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			aagaagaaaggaaaaaaaaaga	0.312													2	4	---	---	---	---					
ZNF330	27309	broad.mit.edu	37	4	142143532	142143532	+	Frame_Shift_Del	DEL	A	A	-			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr4:142143532delA	ENST00000262990.4	+	2	235	c.7delA	c.(7-9)aafs	p.K5fs	ZNF330_ENST00000421169.2_5'UTR	NM_014487.4	NP_055302.1	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	5						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding	p.K5fs*18(1)		kidney(1)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	14	all_hematologic(180;0.162)					GAAAATGCCTAAAAAAAAGAC	0.353													7	30	---	---	---	---					
ERICH1-AS1	619343	broad.mit.edu	37	8	844731	844732	+	RNA	INS	-	-	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr8:844731_844732insG	ENST00000524139.1	+	0	151				ERICH1-AS1_ENST00000522092.1_RNA|ERICH1-AS1_ENST00000577187.1_RNA|ERICH1-AS1_ENST00000578889.1_RNA																							GGTGGCTGGCAGGGCAGGGTGG	0.713													3	6	---	---	---	---					
RFX7	64864	broad.mit.edu	37	15	56535420	56535421	+	Frame_Shift_Ins	INS	-	-	G			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr15:56535420_56535421insG	ENST00000423270.1	-	1	62_63	c.63_64insC	c.(61-66)ccgcgcfs	p.R22fs	RFX7_ENST00000559447.2_5'UTR|RFX7_ENST00000317318.6_Frame_Shift_Ins_p.R22fs|RFX7_ENST00000422057.1_5'UTR	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	666					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						TTGGGGGCGCTGGGGGGAAGCT	0.653													2	4	---	---	---	---					
DNAH3	55567	broad.mit.edu	37	16	21132130	21132132	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr16:21132130_21132132delCAG	ENST00000261383.3	-	11	1627_1629	c.1628_1630delCTG	c.(1627-1632)gat>g	p.AD543del	CTC-508F8.1_ENST00000575612.1_RNA|DNAH3_ENST00000415178.1_In_Frame_Del_p.AD543del	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	543	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CATTGCCGATCAGCAGCAGCAGC	0.498													7	116	---	---	---	---					
CTB-147C22.9	0	broad.mit.edu	37	19	51478657	51478657	+	RNA	DEL	T	T	-	rs71185783		TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr19:51478657delT	ENST00000594512.1	+	0	297																											gaggggctggtggggggggtt	0.687													2	4	---	---	---	---					
CTB-147C22.9	0	broad.mit.edu	37	19	51478666	51478666	+	RNA	DEL	T	T	-			TCGA-86-8055-01A-11D-2238-08	TCGA-86-8055-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a52fb9cb-1e02-4ee2-b532-e94a2b98c07f	7a62fd11-7a78-4cde-bacd-b5d2ceb6cdb4	g.chr19:51478666delT	ENST00000594512.1	+	0	297																											gtggggggggttctgaactcc	0.687													2	4	---	---	---	---