Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CYP2A6	1548	broad.mit.edu	37	19	41354569	41354569	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr19:41354569C>T	ENST00000301141.5	-	3	463	c.443G>A	c.(442-444)cGc>cAc	p.R148H	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753.3	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	148					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	CTCCTGGATGCGCTCCTCGAT	0.692000													4	163					0	0	1	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905220	144905220	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chrX:144905220G>T	ENST00000370490.1	+	1	5532	c.1277G>T	c.(1276-1278)cGc>cTc	p.R426L	SLITRK2_ENST00000428560.2_Missense_Mutation_p.R426L|SLITRK2_ENST00000434188.2_Missense_Mutation_p.R426L|SLITRK2_ENST00000413937.2_Missense_Mutation_p.R426L|SLITRK2_ENST00000447897.2_Missense_Mutation_p.R426L			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	426						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					ACCAGTTTACGCAGACTTTAT	0.393000													6	315					0.0293803	0.0314789	1	1	0
PCDHA6	56142	broad.mit.edu	37	5	140209731	140209731	+	Silent	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr5:140209731C>T	ENST00000529310.1	+	1	2169	c.2055C>T	c.(2053-2055)ggC>ggT	p.G685G	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTCGGTGGGCGCCGCGGGCC	0.662000													10	190					0	0	1	0	0
ELL3	80237	broad.mit.edu	37	15	44065388	44065388	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr15:44065388C>T	ENST00000319359.3	-	11	1761	c.1120G>A	c.(1120-1122)Gag>Aag	p.E374K	RP11-296A16.1_ENST00000417761.2_3'UTR|PDIA3_ENST00000300289.5_3'UTR|ELL3_ENST00000497465.1_5'UTR	NM_025165.2	NP_079441.1	Q9HB65	ELL3_HUMAN	elongation factor RNA polymerase II-like 3	374					positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				cervix(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|skin(1)	13		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)		TGAAGGTACTCACAGCGACGC	0.433000													8	162					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25677815	25677815	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr4:25677815C>T	ENST00000382051.3	+	13	1567	c.1517C>T	c.(1516-1518)cCg>cTg	p.P506L	SLC34A2_ENST00000503434.1_Missense_Mutation_p.P505L|SLC34A2_ENST00000504570.1_Missense_Mutation_p.P505L	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	506					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TACCCGATCCCGTTCACTCGC	0.567000			T	ROS1	NSCLC								20	135					0	0	1	0	0
GDPD2	54857	broad.mit.edu	37	X	69652158	69652158	+	Splice_Site	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chrX:69652158G>A	ENST00000453994.2	+	14	1823	c.1460_splice	c.e14-1	p.A488_splice	GDPD2_ENST00000538649.1_Splice_Site_p.A358_splice|GDPD2_ENST00000536730.1_Splice_Site_p.A358_splice|GDPD2_ENST00000374382.3_Splice_Site_p.A437_splice|GDPD2_ENST00000472623.1_3'UTR	NM_001171192.1	NP_001164663.1	Q9HCC8	GDPD2_HUMAN	glycerophosphodiester phosphodiesterase domain containing 2	437					glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|large_intestine(8)|lung(3)|ovary(2)	22	Renal(35;0.156)					CCTTCACAGGGCATTGCATAA	0.517000													4	236					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38783304	38783304	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr6:38783304C>A	ENST00000359357.3	+	24	2997	c.2743C>A	c.(2743-2745)Ctg>Atg	p.L915M	DNAH8_ENST00000449981.2_Missense_Mutation_p.L1132M|DNAH8_ENST00000441566.1_Missense_Mutation_p.L915M					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CCAGTTAACCCTGGAGGTCAG	0.488000													15	83					5.03518e-11	6.00789e-11	1	1	0
UBR4	23352	broad.mit.edu	37	1	19524200	19524200	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:19524200G>A	ENST00000375267.2	-	7	860	c.857C>T	c.(856-858)cCt>cTt	p.P286L	UBR4_ENST00000375226.2_Missense_Mutation_p.P286L|UBR4_ENST00000375254.3_Missense_Mutation_p.P286L|UBR4_ENST00000375217.2_Missense_Mutation_p.P286L			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	286					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TACTGTTGCAGGCATTATGAA	0.433000													27	272					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871058	170871058	+	Silent	SNP	G	G	A	rs113440919		TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr6:170871058G>A	ENST00000392092.2	+	3	513	c.234G>A	c.(232-234)caG>caA	p.Q78Q	TBP_ENST00000540980.1_Silent_p.Q58Q|TBP_ENST00000230354.6_Silent_p.Q78Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	78	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.577000													4	90					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42458395	42458395	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr15:42458395C>A	ENST00000318006.5	-	16	1804	c.1642G>T	c.(1642-1644)Gtg>Ttg	p.V548L	VPS39_ENST00000348544.4_Missense_Mutation_p.V559L	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	559					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		AGCACCCACACTGAGTAGGAG	0.502000													4	134					1	1	1	1	0
PLEKHB2	55041	broad.mit.edu	37	2	131890480	131890480	+	Silent	SNP	T	T	C			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr2:131890480T>C	ENST00000403716.1	+	6	899	c.339T>C	c.(337-339)taT>taC	p.Y113Y	PLEKHB2_ENST00000404460.1_Silent_p.Y113Y|PLEKHB2_ENST00000303908.3_Silent_p.Y113Y|PLEKHB2_ENST00000538982.1_Silent_p.Y65Y|PLEKHB2_ENST00000234115.6_Silent_p.Y113Y|PLEKHB2_ENST00000409279.1_Silent_p.Y113Y|PLEKHB2_ENST00000409158.1_Silent_p.Y113Y|PLEKHB2_ENST00000439822.2_Intron|PLEKHB2_ENST00000409612.1_Silent_p.Y113Y|PLEKHB2_ENST00000438882.2_Silent_p.Y113Y	NM_001100623.1|NM_001267062.1|NM_001267063.1|NM_001267064.1|NM_001267065.1|NM_001267066.1|NM_017958.2	NP_001094093.1|NP_001253991.1|NP_001253992.1|NP_001253993.1|NP_001253994.1|NP_001253995.1|NP_060428.2	Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	113						membrane	protein binding			large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		CGCAGGCGTATGTGGGCTCTG	0.547000													6	175					0	0	1	0	0
BCAS2	10286	broad.mit.edu	37	1	115118251	115118251	+	Missense_Mutation	SNP	T	T	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:115118251T>A	ENST00000369541.3	-	4	426	c.379A>T	c.(379-381)Atg>Ttg	p.M127L	BCAS2_ENST00000485021.1_5'UTR	NM_005872.2	NP_005863.1	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	127					mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			biliary_tract(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)	13	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGCTGTGACATTAGTTCCAGA	0.353000													4	129					0	0	1	0	0
OR4F6	390648	broad.mit.edu	37	15	102346711	102346711	+	Silent	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr15:102346711C>T	ENST00000328882.4	+	1	810	c.789C>T	c.(787-789)ccC>ccT	p.P263P		NM_001005326.1	NP_001005326.1	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F, member 6	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(1)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			TTCCATTTCCCACATCACATC	0.378000													9	147					0	0	1	0	0
NELFCD	51497	broad.mit.edu	37	20	57569701	57569701	+	Silent	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr20:57569701C>T	ENST00000602795.1	+	15	1818	c.1770C>T	c.(1768-1770)caC>caT	p.H590H	NELFCD_ENST00000344018.3_Silent_p.H581H|NELFCD_ENST00000479207.1_3'UTR					negative elongation factor complex member C/D																		TTAAAGCTCACTGCAAATCTA	0.373000													4	170					0	0	1	0	0
ZNF426	79088	broad.mit.edu	37	19	9639460	9639460	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr19:9639460C>T	ENST00000593003.1	-	6	1624	c.1147G>A	c.(1147-1149)Gag>Aag	p.E383K	ZNF426_ENST00000535489.1_Missense_Mutation_p.E421K|ZNF426_ENST00000253115.2_Missense_Mutation_p.E421K			Q9BUY5	ZN426_HUMAN	zinc finger protein 426	421					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20						ATCTTACACTCACAGGCCTTC	0.433000													11	128					0	0	1	0	0
GAB3	139716	broad.mit.edu	37	X	153944560	153944560	+	Silent	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chrX:153944560G>A	ENST00000369575.3	-	2	148	c.117C>T	c.(115-117)agC>agT	p.S39S	GAB3_ENST00000424127.2_Silent_p.S39S|GAB3_ENST00000496390.1_5'UTR	NM_001081573.1|NM_080612.2	NP_001075042.1|NP_542179.1	Q8WWW8	GAB3_HUMAN	GRB2-associated binding protein 3	39	PH.									NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)	25	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CGGGGTTGCCGCTCATGCGGC	0.562000													4	164					0	0	1	0	0
LYSMD1	388695	broad.mit.edu	37	1	151134229	151134229	+	Silent	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:151134229C>T	ENST00000368908.5	-	2	1188	c.528G>A	c.(526-528)ctG>ctA	p.L176L	LYSMD1_ENST00000440902.2_Silent_p.L128L	NM_212551.4	NP_997716.1	Q96S90	LYSM1_HUMAN	LysM, putative peptidoglycan-binding, domain containing 1	176					cell wall macromolecule catabolic process					endometrium(2)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCCCTTTTTTCAGCTTCTGAG	0.468000													5	247					0	0	1	0	0
FEM1A	55527	broad.mit.edu	37	19	4793724	4793724	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr19:4793724C>A	ENST00000269856.3	+	1	1997	c.1858C>A	c.(1858-1860)Ctg>Atg	p.L620M	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	620					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity	p.L620M(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GGCCTACGAGCTGCTGGACGA	0.607000													5	64					1	1	1	1	0
ANKRD30BP3	338579	broad.mit.edu	37	10	45652235	45652235	+	RNA	SNP	C	C	G	rs149362183		TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr10:45652235C>G	ENST00000427229.2	+	0	1749																											GAAGGAACATCTGAAGGAACA	0.478000													6	18					0	0	1	0	0
LCA5	167691	broad.mit.edu	37	6	80197408	80197408	+	Silent	SNP	A	A	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr6:80197408A>T	ENST00000392959.1	-	9	2018	c.1407T>A	c.(1405-1407)gcT>gcA	p.A469A	LCA5_ENST00000369846.4_Silent_p.A469A	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	469					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		CATTCAGTTTAGCAAGTAGCA	0.378000													4	175					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53062469	53062469	+	Silent	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr8:53062469G>A	ENST00000276480.7	-	16	2558	c.1875C>T	c.(1873-1875)gaC>gaT	p.D625D		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	625						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				GTGCAGACTTGTCCAGGATTC	0.408000													15	123					0	0	1	0	0
BCOR	54880	broad.mit.edu	37	X	39923084	39923084	+	Missense_Mutation	SNP	T	T	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chrX:39923084T>A	ENST00000342274.4	-	8	3884	c.3522A>T	c.(3520-3522)caA>caT	p.Q1174H	BCOR_ENST00000378463.1_Missense_Mutation_p.Q51H|BCOR_ENST00000378444.4_Missense_Mutation_p.Q1208H|BCOR_ENST00000378455.4_Missense_Mutation_p.Q1156H|BCOR_ENST00000397354.3_Missense_Mutation_p.Q1174H	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	1208					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						GCAAGTGGCGTTGTTTTTTAG	0.512000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						30	117					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	569666	569666	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr12:569666G>A	ENST00000266383.5	+	1	137	c.124G>A	c.(124-126)Gaa>Aaa	p.E42K		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	42						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			TCTGTATCTGGAACTGGTGGC	0.731000													9	33					0	0	1	0	0
FAM120A	23196	broad.mit.edu	37	9	96305693	96305693	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr9:96305693C>T	ENST00000277165.6	+	11	2293	c.2099C>T	c.(2098-2100)cCa>cTa	p.P700L	FAM120A_ENST00000333936.5_Missense_Mutation_p.P728L|FAM120A_ENST00000340893.4_Missense_Mutation_p.P700L	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	700						cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TCGGACACCCCAGCCATGCTC	0.637000													6	139					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1272626	1272626	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr11:1272626C>G	ENST00000447027.1	+	31	14583	c.14525C>G	c.(14524-14526)tCc>tGc	p.S4842C	MUC5B_ENST00000529681.1_Missense_Mutation_p.S4839C			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4839	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCCACCCTGTCCTCCACCCCA	0.647000													7	355					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18916757	18916757	+	Silent	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr17:18916757G>A	ENST00000317977.6	+	9	1387	c.816G>A	c.(814-816)ctG>ctA	p.L272L	SLC5A10_ENST00000417251.2_Intron|SLC5A10_ENST00000395647.2_Silent_p.L355L|SLC5A10_ENST00000395643.2_Silent_p.L312L|SLC5A10_ENST00000395645.3_Silent_p.L339L|SLC5A10_ENST00000395642.1_Silent_p.L272L			A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	339					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						CCGAGTGCCTGCGGGCCTGCG	0.632000													8	140					0	0	1	0	0
PPOX	5498	broad.mit.edu	37	1	161140283	161140283	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:161140283G>A	ENST00000367999.4	+	10	1338	c.1072G>A	c.(1072-1074)Ggg>Agg	p.G358R	PPOX_ENST00000432542.2_Missense_Mutation_p.G103R|PPOX_ENST00000495483.1_3'UTR|PPOX_ENST00000352210.5_Missense_Mutation_p.G358R|PPOX_ENST00000544598.1_Intron|PPOX_ENST00000535223.1_Intron	NM_001122764.1	NP_001116236.1	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	358					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(3)	15	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TGAGCAGGACGGGAGCCCCCC	0.547000													11	127					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38119859	38119859	+	Silent	SNP	C	C	T	rs66505048		TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr22:38119859C>T	ENST00000406386.3	+	7	1551	c.1296C>T	c.(1294-1296)tgC>tgT	p.C432C	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	432					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding	p.C432C(6)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GAACATCCTGCGCCCAGCGGG	0.582000													5	282					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70926037	70926037	+	Silent	SNP	G	G	C			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr14:70926037G>C	ENST00000603540.1	+	2	2079	c.1821G>C	c.(1819-1821)gtG>gtC	p.V607V	ADAM21_ENST00000267499.3_Silent_p.V607V|RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	607	Cys-rich.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TTGGTGAAGTGAAAGATGGTA	0.433000													4	99					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51890704	51890704	+	Missense_Mutation	SNP	C	C	T	rs141972092		TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr6:51890704C>T	ENST00000371117.3	-	32	4179	c.3904G>A	c.(3904-3906)Gta>Ata	p.V1302I	PKHD1_ENST00000340994.4_Missense_Mutation_p.V1302I	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1302	IPT/TIG 8; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GCAGTGACTACTGGTGTTGCT	0.542000													26	117					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70812039	70812039	+	Missense_Mutation	SNP	A	A	C			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr5:70812039A>C	ENST00000358731.4	+	21	5064	c.4801A>C	c.(4801-4803)Att>Ctt	p.I1601L	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	1601					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		CAAAGGCATAATTAAGGAAGG	0.373000													4	56					0	0	1	0	0
TCFL5	10732	broad.mit.edu	37	20	61492864	61492864	+	Silent	SNP	C	C	T	rs145355253	byFrequency	TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr20:61492864C>T	ENST00000335351.3	-	1	251	c.159G>A	c.(157-159)gaG>gaA	p.E53E	TCFL5_ENST00000217162.5_Silent_p.E5E	NM_006602.2	NP_006593.2	Q9UL49	TCFL5_HUMAN	transcription factor-like 5 (basic helix-loop-helix)	53					cell differentiation|multicellular organismal development|regulation of cell differentiation|regulation of cell proliferation|spermatogenesis|transcription from RNA polymerase II promoter		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(1)|urinary_tract(1)	9	Breast(26;5.68e-08)					GCTGCGTGTACTCCACCTCCG	0.741000													22	61					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24388545	24388545	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:24388545C>A	ENST00000330966.7	-	33	3996	c.3834G>T	c.(3832-3834)gaG>gaT	p.E1278D	MYOM3_ENST00000338909.5_Missense_Mutation_p.E168D|MYOM3_ENST00000374434.3_Missense_Mutation_p.E1275D|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	1275										NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GAAGCCAGATCTCATCCAGGG	0.527000													6	368					0.0293803	0.0314789	1	1	0
OR2W3	343171	broad.mit.edu	37	1	248059593	248059593	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:248059593G>C	ENST00000537741.1	+	3	962	c.705G>C	c.(703-705)caG>caC	p.Q235H	OR2W3_ENST00000360358.3_Missense_Mutation_p.Q235H			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CAGGAAGGCAGAAGGCCTTCG	0.532000													5	316					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74289004	74289004	+	Missense_Mutation	SNP	G	G	A	rs143499534	byFrequency	TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr17:74289004G>A	ENST00000262765.5	-	4	1485	c.1306C>T	c.(1306-1308)Cgg>Tgg	p.R436W		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	436	Gln-rich.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						attccaggccggaccaaacca	0.557000													3	78					0	0	1	0	0
CCDC91	55297	broad.mit.edu	37	12	28637039	28637039	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr12:28637039G>C	ENST00000545336.1	+	15	1575	c.1156G>C	c.(1156-1158)Gaa>Caa	p.E386Q	CCDC91_ENST00000306172.5_Missense_Mutation_p.E356Q|CCDC91_ENST00000540401.1_3'UTR|CCDC91_ENST00000539107.1_Missense_Mutation_p.E350Q|CCDC91_ENST00000381259.1_Missense_Mutation_p.E386Q|CCDC91_ENST00000381256.1_Missense_Mutation_p.E350Q			Q7Z6B0	CCD91_HUMAN	coiled-coil domain containing 91	386	Homodimerization.				protein transport	Golgi apparatus|membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|skin(1)	22	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					AAAGGCTGTGGAAGAGGCAGT	0.383000													8	28					0	0	1	0	0
FIG4	9896	broad.mit.edu	37	6	110081456	110081456	+	Silent	SNP	C	C	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr6:110081456C>A	ENST00000230124.3	+	11	1265	c.1141C>A	c.(1141-1143)Cga>Aga	p.R381R	FIG4_ENST00000441478.2_Silent_p.R104R	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	381	SAC.				cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		GATAAAGGAACGAGAGAAAAG	0.333000													14	57					2.62699e-14	3.2451e-14	1	1	0
RNF113A	7737	broad.mit.edu	37	X	119005322	119005322	+	Silent	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chrX:119005322G>A	ENST00000371442.2	-	1	469	c.255C>T	c.(253-255)agC>agT	p.S85S		NM_006978.2	NP_008909.1	O15541	R113A_HUMAN	ring finger protein 113A	85							nucleic acid binding|zinc ion binding	p.S85S(1)		NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(6)	15						CTTCCTCTTCGCTGCTCAAGT	0.552000													17	388					0	0	1	0	0
DAP3	7818	broad.mit.edu	37	1	155699050	155699050	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:155699050G>C	ENST00000368336.5	+	9	860	c.736G>C	c.(736-738)Gag>Cag	p.E246Q	DAP3_ENST00000421487.2_Missense_Mutation_p.E212Q|DAP3_ENST00000343043.3_Missense_Mutation_p.E246Q|DAP3_ENST00000535183.1_Missense_Mutation_p.E205Q|MSTO1_ENST00000538143.1_Intron|MSTO1_ENST00000452804.2_Intron|DAP3_ENST00000471214.1_3'UTR	NM_001199849.1|NM_004632.3	NP_001186778.1|NP_004623.1	P51398	RT29_HUMAN	death associated protein 3	246					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	24	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TGTGCTGAAAGAGCTAAAGAG	0.473000													8	166					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108622615	108622615	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr2:108622615G>A	ENST00000264047.2	+	7	1128	c.852G>A	c.(850-852)atG>atA	p.M284I	SLC5A7_ENST00000409059.1_Missense_Mutation_p.M284I|SLC5A7_ENST00000540517.1_Missense_Mutation_p.M179I	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	284					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	GCCTGGTGATGGCCATCCCAG	0.522000													34	93					0	0	1	0	0
CCDC36	339834	broad.mit.edu	37	3	49294343	49294343	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr3:49294343C>G	ENST00000438782.1	+	8	1649	c.1413C>G	c.(1411-1413)ttC>ttG	p.F471L	CCDC36_ENST00000452691.2_Missense_Mutation_p.F471L|CCDC36_ENST00000296449.5_Missense_Mutation_p.F471L			Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	471										endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|urinary_tract(3)	14				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		CCTGTAAATTCAATTCCAAAT	0.542000													5	322					0	0	1	0	0
C17orf70	80233	broad.mit.edu	37	17	79517622	79517622	+	Missense_Mutation	SNP	T	T	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr17:79517622T>A	ENST00000537152.1	-	3	970	c.445A>T	c.(445-447)Aat>Tat	p.N149Y	C17orf70_ENST00000327787.8_Missense_Mutation_p.N300Y	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	300					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			GGCAGAAAATTCTCTGCAGCT	0.577000													9	206					0	0	1	0	0
GGT3P	2679	broad.mit.edu	37	22	18778603	18778603	+	RNA	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr22:18778603C>T	ENST00000412448.1	-	0	802																											TTGGCATCCGCGGCCACGGCA	0.627000													7	22					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414687	105414687	+	Silent	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr14:105414687G>A	ENST00000333244.5	-	7	7220	c.7101C>T	c.(7099-7101)agC>agT	p.S2367S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2367						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGGGCTGAACGCTGAGGTCAG	0.657000													11	429					0	0	1	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12918890	12918890	+	Missense_Mutation	SNP	T	T	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:12918890T>A	ENST00000240189.2	+	2	113	c.26T>A	c.(25-27)cTa>cAa	p.L9Q		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	9										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCACCGAGACTACTGGAGCTG	0.552000													6	282					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916924	178916924	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr3:178916924C>T	ENST00000263967.3	+	2	468	c.311C>T	c.(310-312)cCa>cTa	p.P104L		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	104	PI3K-ABD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.P104L(1)|p.P104R(1)|p.P104_G106>R(1)|p.E103_G106>D(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GTAATTGAACCAGTAGGCAAC	0.353000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			30	111					0	0	1	0	0
IGKV1D-13	28902	broad.mit.edu	37	2	90193232	90193232	+	RNA	SNP	T	T	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr2:90193232T>A	ENST00000390275.2	+	0	339																											GCATTAGCAGTGCTTTAGCCT	0.537000													79	203					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													4	109					0	0	1	0	0
TIAM2	26230	broad.mit.edu	37	6	155458655	155458655	+	Silent	SNP	C	C	G			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr6:155458655C>G	ENST00000461783.3	+	7	2812	c.1539C>G	c.(1537-1539)ctC>ctG	p.L513L	TIAM2_ENST00000529824.2_Silent_p.L513L|TIAM2_ENST00000318981.5_Silent_p.L513L|TIAM2_ENST00000360366.4_Silent_p.L513L|TIAM2_ENST00000456144.1_Silent_p.L513L|TIAM2_ENST00000367174.2_5'UTR			Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	513	PH 1.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(20)|lung(21)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	65		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		CCGGGTGGCTCTTCTTCAAGC	0.562000													4	105					0	0	1	0	0
GRAMD4	23151	broad.mit.edu	37	22	47022830	47022830	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr22:47022830C>T	ENST00000406902.1	+	2	347	c.134C>T	c.(133-135)cCc>cTc	p.P45L	GRAMD4_ENST00000490378.1_Intron|GRAMD4_ENST00000361034.3_Missense_Mutation_p.P45L			Q6IC98	GRAM4_HUMAN	GRAM domain containing 4	45					apoptosis	integral to membrane|mitochondrial membrane				breast(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|skin(1)	12		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		CGGACCTCGCCCCGGGACAGC	0.647000													33	135					0	0	1	0	0
HNRNPH2	3188	broad.mit.edu	37	X	100667389	100667389	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chrX:100667389C>G	ENST00000316594.5	+	2	491	c.413C>G	c.(412-414)cCa>cGa	p.P138R		NM_001032393.2|NM_001199973.1|NM_001199974.1|NM_019597.4	NP_001027565.1|NP_001186902.1|NP_001186903.1|NP_062543.1	P55795	HNRH2_HUMAN	heterogeneous nuclear ribonucleoprotein H2 (H')	138	RRM 2.				nuclear mRNA splicing, via spliceosome	actin cytoskeleton|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(3)|large_intestine(2)|lung(6)|skin(1)	12						GAAATTGTGCCAAATGGGATG	0.498000													7	170					0	0	1	0	0
MPO	4353	broad.mit.edu	37	17	56355289	56355289	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr17:56355289C>T	ENST00000340482.3	-	6	1375	c.1199G>A	c.(1198-1200)cGc>cAc	p.R400H	MPO_ENST00000225275.3_Missense_Mutation_p.R368H|MPO_ENST00000578493.1_5'UTR			P05164	PERM_HUMAN	myeloperoxidase	368					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	GTCTTGGAAGCGCTGGTTGAC	0.652000													12	137					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr7:55259515T>G	ENST00000275493.2	+	21	2750	c.2573T>G	c.(2572-2574)cTg>cGg	p.L858R	EGFR_ENST00000455089.1_Missense_Mutation_p.L813R|EGFR_ENST00000454757.2_Missense_Mutation_p.L805R|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	858	Protein kinase.		L -> M (found in a lung cancer sample).|L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(1489)|p.L858Q(1)|p.L858K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537000	L858R(NCIH1975_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			51	202					0	0	1	0	0
RCC1	1104	broad.mit.edu	37	1	28863387	28863387	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:28863387G>T	ENST00000373833.6	+	12	1351	c.1066G>T	c.(1066-1068)Gtg>Ttg	p.V356L	RCC1_ENST00000373831.3_Missense_Mutation_p.V387L|RCC1_ENST00000373832.1_Missense_Mutation_p.V356L|RCC1_ENST00000398958.2_Missense_Mutation_p.V356L			P18754	RCC1_HUMAN	regulator of chromosome condensation 1	356					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		TGGGGCCTCTGTGGGGTATGC	0.597000													9	364					1.12685e-05	1.27225e-05	1	1	0
DSCR9	257203	broad.mit.edu	37	21	38593667	38593667	+	RNA	SNP	T	T	C			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr21:38593667T>C	ENST00000454482.2	+	0	1274					NR_026719.2																						TGACCACGCCTACAGCCGAAG	0.652000													5	119					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18156872	18156872	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr17:18156872G>T	ENST00000327031.4	-	8	1066	c.841C>A	c.(841-843)Ctc>Atc	p.L281I	FLII_ENST00000545457.2_Missense_Mutation_p.L227I|FLII_ENST00000584444.1_Intron|FLII_ENST00000578558.1_Missense_Mutation_p.L281I|FLII_ENST00000579294.1_Missense_Mutation_p.L270I|FLII_ENST00000379450.4_Missense_Mutation_p.L196I	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	281	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					AGTGAGGTGAGCTGATTTCGG	0.642000													6	233					1	1	1	1	0
ACACA	31	broad.mit.edu	37	17	35614667	35614667	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr17:35614667C>A	ENST00000353139.5	-	14	2265	c.1784G>T	c.(1783-1785)gGt>gTt	p.G595V	ACACA_ENST00000394406.2_Missense_Mutation_p.G558V|ACACA_ENST00000360679.3_Missense_Mutation_p.G500V|ACACA_ENST00000335166.5_Missense_Mutation_p.G480V	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	558	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	AAAGCAGTGACCAAACTGAGA	0.383000													4	96					1	1	1	1	0
ZNF823	55552	broad.mit.edu	37	19	11833207	11833207	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr19:11833207G>T	ENST00000341191.6	-	4	1295	c.1142C>A	c.(1141-1143)aCa>aAa	p.T381K	ZNF823_ENST00000545749.1_Missense_Mutation_p.T199K	NM_001080493.2	NP_001073962.1	P16415	ZN823_HUMAN	zinc finger protein 823	381					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)	26						TCCTGTGTGTGTTATCATGTG	0.428000										HNSCC(68;0.2)			5	161					0.00116845	0.00130518	1	1	0
CSAG4	100130935	broad.mit.edu	37	X	151896589	151896589	+	RNA	SNP	C	C	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chrX:151896589C>A	ENST00000361201.4	-	0	351					NR_073432.1													p.L11F(1)		endometrium(2)|kidney(2)|lung(1)	5						GGTTGTTGGACAATGGGCTGG	0.557000													6	314					0.00448238	0.0049026	1	1	0
NCAPD2	9918	broad.mit.edu	37	12	6627032	6627032	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr12:6627032G>T	ENST00000315579.5	+	13	2295	c.1496G>T	c.(1495-1497)gGa>gTa	p.G499V	NCAPD2_ENST00000545962.1_Missense_Mutation_p.G454V	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	499	Interactions with SMC2 and SMC4.				cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						CTTCCCCAGGGAGAGGAGGAG	0.507000													4	111					0.184627	0.193859	1	1	0
RBM47	54502	broad.mit.edu	37	4	40438646	40438646	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr4:40438646C>T	ENST00000381793.2	-	4	1538	c.1142G>A	c.(1141-1143)cGa>cAa	p.R381Q	RBM47_ENST00000381795.6_Intron|RBM47_ENST00000319592.4_Intron|RBM47_ENST00000295971.7_Missense_Mutation_p.R381Q|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000514014.1_Missense_Mutation_p.R343Q			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	381						nucleus	nucleotide binding|RNA binding	p.R381P(1)		breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						ACCTCGCCCTCGGCCTCTTAT	0.552000													5	250					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73675265	73675265	+	Silent	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr2:73675265C>T	ENST00000264448.6	+	8	1719	c.1608C>T	c.(1606-1608)ctC>ctT	p.L536L	ALMS1_ENST00000409009.1_Silent_p.L494L|ALMS1_ENST00000377715.1_Silent_p.L536L	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	536					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						CTGATACTCTCAACCAAAAGA	0.428000													38	105					0	0	1	0	0
RFX3	5991	broad.mit.edu	37	9	3330515	3330515	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr9:3330515C>A	ENST00000382004.3	-	5	529	c.218G>T	c.(217-219)cGa>cTa	p.R73L	RFX3_ENST00000358730.2_Missense_Mutation_p.R73L|RFX3_ENST00000302303.1_Missense_Mutation_p.R73L	NM_134428.1	NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)	73					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		CGTTGTTGTTCGGCTTTAGAA	0.348000													4	109					1	1	1	1	0
FOXQ1	94234	broad.mit.edu	37	6	1313481	1313481	+	Missense_Mutation	SNP	T	T	C			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr6:1313481T>C	ENST00000296839.2	+	1	807	c.542T>C	c.(541-543)cTg>cCg	p.L181P		NM_033260.3	NP_150285.3	Q9C009	FOXQ1_HUMAN	forkhead box Q1	181					DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			lung(1)|urinary_tract(1)	2	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		GTCAAGGTGCTGCGCGACCCC	0.642000													28	153					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198285796	198285796	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr2:198285796G>A	ENST00000335508.5	-	3	348	c.257C>T	c.(256-258)gCc>gTc	p.A86V	SF3B1_ENST00000414963.2_Missense_Mutation_p.A86V|SF3B1_ENST00000487698.1_Missense_Mutation_p.A86V|SF3B1_ENST00000409915.4_Missense_Mutation_p.A86V	NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	86					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGCCACAGGGGCATGATATCC	0.388000			Mis		myelodysplastic syndrome								17	215					0	0	1	0	0
NPTXR	23467	broad.mit.edu	37	22	39224291	39224291	+	Splice_Site	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr22:39224291C>T	ENST00000333039.2	-	2	974		c.e2+1			NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor							integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					CCAGGACCCACCGTGCTCCAG	0.597000													31	149					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844888	18844888	+	RNA	SNP	A	A	G			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr22:18844888A>G	ENST00000412938.1	+	0	3138																											GCTCACGGAAATACAGCTTCA	0.587000													5	78					0	0	1	0	0
CDX2	1045	broad.mit.edu	37	13	28542667	28542667	+	Silent	SNP	G	G	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr13:28542667G>T	ENST00000381020.7	-	1	2609	c.477C>A	c.(475-477)ggC>ggA	p.G159G		NM_001265.4	NP_001256.3	Q99626	CDX2_HUMAN	caudal type homeobox 2	159					organ morphogenesis|transcription from RNA polymerase II promoter		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(1)|lung(6)	9	all_cancers(110;0.191)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0407)|all cancers(112;0.0491)|OV - Ovarian serous cystadenocarcinoma(117;0.199)		GCCGCTGGCCGCCGGGAGACA	0.736000			T	ETV6	AML								6	41					5.18039e-06	6.04379e-06	1	1	0
LAX1	54900	broad.mit.edu	37	1	203743757	203743757	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:203743757G>T	ENST00000442561.2	+	5	1535	c.1145G>T	c.(1144-1146)gGa>gTa	p.G382V	LAX1_ENST00000367217.5_Missense_Mutation_p.G366V|LAX1_ENST00000367215.1_3'UTR	NM_017773.3	NP_060243.2	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1	382					B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)|endometrium(3)|large_intestine(2)|lung(13)|prostate(1)|stomach(1)|urinary_tract(2)	24	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GCCAAGTTAGGAGGCAGGGAC	0.488000													8	142					1.12685e-05	1.27225e-05	1	1	0
BRINP2	57795	broad.mit.edu	37	1	177247895	177247895	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:177247895G>T	ENST00000361539.4	+	7	1521	c.1209G>T	c.(1207-1209)caG>caT	p.Q403H	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		403						extracellular region		p.Q403H(1)		breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						GCCATCGCCAGCCTCGCTTCC	0.622000													13	179					4.93089e-13	5.95108e-13	1	1	0
ITGA2	3673	broad.mit.edu	37	5	52368966	52368966	+	Silent	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr5:52368966C>T	ENST00000296585.5	+	20	2591	c.2448C>T	c.(2446-2448)gtC>gtT	p.V816V		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	816					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CCTTTATTGTCAGCAACCAAA	0.313000													4	105					0	0	1	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905221	144905221	+	Silent	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chrX:144905221C>T	ENST00000370490.1	+	1	5533	c.1278C>T	c.(1276-1278)cgC>cgT	p.R426R	SLITRK2_ENST00000428560.2_Silent_p.R426R|SLITRK2_ENST00000434188.2_Silent_p.R426R|SLITRK2_ENST00000413937.2_Silent_p.R426R|SLITRK2_ENST00000447897.2_Silent_p.R426R			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	426						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGTTTACGCAGACTTTATC	0.393000													6	317					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058353	11058353	+	RNA	SNP	T	T	C	rs79433933	by1000genomes	TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr21:11058353T>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAAATCTCTTTATAAAACCTT	0.343000													10	140					0	0	1	0	0
HOXA10	3206	broad.mit.edu	37	7	27211519	27211519	+	Silent	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr7:27211519C>T	ENST00000283921.4	-	2	1231	c.1232G>A	c.(1231-1233)tGa>tAa	p.*411*	HOXA10_ENST00000521421.1_5'UTR|RP1-170O19.20_ENST00000470747.4_Intron|HOXA10_ENST00000396344.4_Silent_p.*95*|RP1-170O19.20_ENST00000465941.1_Intron|HOXA-AS4_ENST00000519935.1_RNA	NM_018951.3	NP_061824.3	P31260	HXA10_HUMAN	homeobox A10	0					spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	9						GGAGATTCATCAGGAAAAATT	0.517000													9	176					0	0	1	0	0
COLEC12	81035	broad.mit.edu	37	18	347278	347278	+	Missense_Mutation	SNP	A	A	G			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr18:347278A>G	ENST00000400256.3	-	5	551	c.344T>C	c.(343-345)aTt>aCt	p.I115T		NM_130386.2	NP_569057.1	Q5KU26	COL12_HUMAN	collectin sub-family member 12	115					carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			cervix(2)|endometrium(3)|kidney(2)|large_intestine(10)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	46		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				GAGATCTAGAATGTCTGATCT	0.458000													85	150					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98779374	98779374	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr2:98779374C>T	ENST00000477737.1	+	8	1253	c.1049C>T	c.(1048-1050)aCg>aTg	p.T350M	VWA3B_ENST00000435344.1_Missense_Mutation_p.T350M|VWA3B_ENST00000451075.2_Missense_Mutation_p.T200M	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	350										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GCCTGCAGCACGCTGGCCCAG	0.587000													6	99					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179733928	179733928	+	Silent	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr2:179733928G>A	ENST00000420890.2	-	15	2427	c.2310C>T	c.(2308-2310)caC>caT	p.H770H	CCDC141_ENST00000295723.5_Silent_p.H195H	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	195							protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			TTTGATGGAAGTGAATAAGGT	0.423000													14	132					0	0	1	0	0
PER1	5187	broad.mit.edu	37	17	8047060	8047060	+	Missense_Mutation	SNP	T	T	G			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr17:8047060T>G	ENST00000317276.4	-	19	2833	c.2596A>C	c.(2596-2598)Acc>Ccc	p.T866P	PER1_ENST00000578089.1_5'UTR|PER1_ENST00000581082.1_Missense_Mutation_p.T843P	NM_002616.2	NP_002607.2	O15534	PER1_HUMAN	period circadian clock 1	866	Pro-rich.				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity	p.T866P(1)		breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GGCCAGGGGGTGGAGGGTGGC	0.667000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes					9	20					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2820010	2820010	+	Silent	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr8:2820010G>A	ENST00000520002.1	-	62	10164	c.9609C>T	c.(9607-9609)agC>agT	p.S3203S	CSMD1_ENST00000602723.1_Silent_p.S3026S|CSMD1_ENST00000400186.3_Silent_p.S3026S|CSMD1_ENST00000602557.1_Silent_p.S3203S|CSMD1_ENST00000542608.1_Silent_p.S3025S|CSMD1_ENST00000537824.1_Silent_p.S3202S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3203	Sushi 26.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTTGTATGCCGCTCCACGTGC	0.468000													3	60					0	0	1	0	0
ANKMY2	57037	broad.mit.edu	37	7	16664699	16664699	+	Silent	SNP	T	T	C			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr7:16664699T>C	ENST00000306999.2	-	4	522	c.279A>G	c.(277-279)aaA>aaG	p.K93K		NM_020319.2	NP_064715.1	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	93						cilium	zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	23	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		ATGTGATGTCTTTATTACCTA	0.408000													33	73					0	0	1	0	0
ACTC1	70	broad.mit.edu	37	15	35083338	35083338	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr15:35083338C>A	ENST00000290378.4	-	6	1622	c.967G>T	c.(967-969)Gct>Tct	p.A323S	RP11-814P5.1_ENST00000503496.1_RNA	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	323					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GTGCTAGGAGCCAGAGCAGTG	0.448000													18	397					2.94398e-08	3.47324e-08	1	1	0
ABTB2	25841	broad.mit.edu	37	11	34378353	34378353	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr11:34378353C>A	ENST00000435224.2	-	1	1202	c.778G>T	c.(778-780)Ggg>Tgg	p.G260W	ABTB2_ENST00000298992.2_Missense_Mutation_p.G74W	NM_145804.2	NP_665803.2	A8K6S9	A8K6S9_HUMAN	ankyrin repeat and BTB (POZ) domain containing 2	74							DNA binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Acute lymphoblastic leukemia(5;0.0508)|all_hematologic(20;0.0691)				GACACCTCCCCGCCTCCGGCC	0.657000													3	36					0.115264	0.12225	1	1	0
KIF4B	285643	broad.mit.edu	37	5	154393963	154393963	+	Missense_Mutation	SNP	T	T	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr5:154393963T>A	ENST00000435029.4	+	1	704	c.544T>A	c.(544-546)Tta>Ata	p.L182I		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	182	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GAAGACTGTTTTAGTTGCCTT	0.468000													67	239					0	0	1	0	0
GGT3P	2679	broad.mit.edu	37	22	18778601	18778601	+	RNA	SNP	C	C	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr22:18778601C>T	ENST00000412448.1	-	0	804																											GCTTGGCATCCGCGGCCACGG	0.627000													4	25					0	0	1	0	0
FABP7	2173	broad.mit.edu	37	6	123101489	123101489	+	Missense_Mutation	SNP	A	A	C			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr6:123101489A>C	ENST00000356535.4	+	2	163	c.127A>C	c.(127-129)Atc>Ctc	p.I43L	FABP7_ENST00000368444.3_Missense_Mutation_p.I43L			O15540	FABP7_HUMAN	fatty acid binding protein 7, brain	43					negative regulation of cell proliferation	cytoplasm	lipid binding|transporter activity			kidney(1)|large_intestine(1)|lung(2)|stomach(1)	5				GBM - Glioblastoma multiforme(226;0.226)	Alpha-Linolenic Acid(DB00132)|gamma-Homolinolenic acid(DB00154)|Icosapent(DB00159)	AACGGTAATTATCAGTCAAGA	0.463000													4	63					0	0	1	0	0
ABCB7	22	broad.mit.edu	37	X	74332726	74332726	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chrX:74332726C>G	ENST00000253577.3	-	3	355	c.331G>C	c.(331-333)Gaa>Caa	p.E111Q	ABCB7_ENST00000373394.3_Missense_Mutation_p.E110Q|ABCB7_ENST00000339447.4_Missense_Mutation_p.E110Q	NM_001271696.1|NM_004299.3	NP_001258625.1|NP_004290.2	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 7	110					cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			breast(1)|endometrium(5)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)	20						CTTACCCCTTCTTTTGGGTCT	0.398000													4	190					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176640151	176640151	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:176640151C>G	ENST00000367662.3	+	4	3201	c.2037C>G	c.(2035-2037)aaC>aaG	p.N679K	PAPPA2_ENST00000367661.3_Missense_Mutation_p.N679K	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	679	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TGCAGCTGAACAGTACTCACT	0.512000													12	366					0	0	1	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42126987	42126987	+	Silent	SNP	G	G	A			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr15:42126987G>A	ENST00000382448.4	+	2	123	c.114G>A	c.(112-114)ccG>ccA	p.P38P	JMJD7_ENST00000397299.4_Silent_p.P38P|JMJD7-PLA2G4B_ENST00000542534.1_Silent_p.P38P|JMJD7_ENST00000408047.1_Intron|JMJD7-PLA2G4B_ENST00000342159.4_Silent_p.P38P|JMJD7_ENST00000405106.2_3'UTR	NM_005090.3	NP_005081.1	P0C869	PA24B_HUMAN		0	C2.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(2)	25						CCCCAACTCCGCTCCACTTCT	0.607000													12	182					0	0	1	0	0
CTBS	1486	broad.mit.edu	37	1	85039999	85040007	+	In_Frame_Del	DEL	GCAGCGCCA	GCAGCGCCA	-	rs3217269		TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:85039999_85040007delGCAGCGCCA	ENST00000370630.4	-	1	140_148	c.92_100delTGGCGCTGC	c.(91-102)cgg>c	p.LALR31del	CTBS_ENST00000477677.1_5'UTR	NM_004388.2	NP_004379.1	Q01459	DIAC_HUMAN	chitobiase, di-N-acetyl-	31						lysosome	cation binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(1)	9				all cancers(265;0.00727)|Epithelial(280;0.0192)|OV - Ovarian serous cystadenocarcinoma(397;0.166)		GCCGCGAGCCgcagcgccagcagcgccag	0.718													6	6	---	---	---	---					
RPL5	6125	broad.mit.edu	37	1	93301834	93301837	+	Frame_Shift_Del	DEL	CAGC	CAGC	-			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr1:93301834_93301837delCAGC	ENST00000370321.3	+	5	502_505	c.412_415delCAGC	c.(412-417)cafs	p.QP138fs		NM_000969.3	NP_000960.2	P46777	RL5_HUMAN	ribosomal protein L5	138					endocrine pancreas development|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	5S rRNA binding|protein binding|structural constituent of ribosome			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		all_lung(203;0.00265)|Lung NSC(277;0.0056)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000305)|all cancers(265;0.000343)|Epithelial(280;0.0927)		CATTGATGGTCAGCCAGGTGCCTT	0.480													28	247	---	---	---	---					
ATP6V1C2	245973	broad.mit.edu	37	2	10917819	10917820	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr2:10917819_10917820delAG	ENST00000272238.4	+	11	1043_1044	c.934_935delAG	c.(934-936)afs	p.R312fs	ATP6V1C2_ENST00000381661.3_Intron	NM_001039362.1	NP_001034451.1	Q8NEY4	VATC2_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2	312					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		GCAGACCGACAGAGAGAGAGAG	0.604													11	218	---	---	---	---					
AC027612.3	0	broad.mit.edu	37	2	91899626	91899626	+	RNA	DEL	A	A	-			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr2:91899626delA	ENST00000436174.1	-	0	168																											CCAGAGGCTCAAAAAAAAAAA	0.289													6	11	---	---	---	---					
HLA-DRB6	3128	broad.mit.edu	37	6	32523362	32523363	+	RNA	INS	-	-	GATA	rs142676080	by1000genomes	TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr6:32523362_32523363insGATA	ENST00000411500.1	-	0	458					NR_001298.1																						AAAGCAATGTGGATAAAGGGAC	0.431													7	13	---	---	---	---					
BCKDHB	594	broad.mit.edu	37	6	80878646	80878646	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr6:80878646delG	ENST00000545529.1	+	5	560	c.532delG	c.(532-534)gafs	p.G178fs	BCKDHB_ENST00000369760.4_Frame_Shift_Del_p.G178fs|BCKDHB_ENST00000356489.5_Frame_Shift_Del_p.G178fs|BCKDHB_ENST00000320393.6_Frame_Shift_Del_p.G178fs			P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1, beta polypeptide	178					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding	p.G178*(1)		central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(1)	15		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		TTTTAACTGTGGAAGCCTCAC	0.498													15	160	---	---	---	---					
RNF20	56254	broad.mit.edu	37	9	104314008	104314009	+	Frame_Shift_Ins	INS	-	-	T			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr9:104314008_104314009insT	ENST00000389120.3	+	11	1405_1406	c.1315_1316insT	c.(1315-1317)tcafs	p.S439fs		NM_019592.5	NP_062538.5	Q5VTR2	BRE1A_HUMAN	ring finger protein 20, E3 ubiquitin protein ligase	439					histone H2B ubiquitination|histone monoubiquitination|negative regulation of cell migration|positive regulation of transcription, DNA-dependent|protein polyubiquitination|ubiquitin-dependent protein catabolic process	nucleolus|ubiquitin ligase complex	histone binding|p53 binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(3)|kidney(6)|large_intestine(7)|lung(23)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_hematologic(171;8.99e-06)|Acute lymphoblastic leukemia(62;0.000365)|Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.88e-19)|STAD - Stomach adenocarcinoma(157;0.00311)		GACTGAAGTAATTCAGCTAGAA	0.386													9	103	---	---	---	---					
DUSP8	1850	broad.mit.edu	37	11	1577819	1577820	+	Frame_Shift_Del	DEL	CG	CG	-	rs61747093		TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr11:1577819_1577820delCG	ENST00000397374.3	-	7	1933_1934	c.1806_1807delCG	c.(1804-1809)cggcfs	p.RG602fs	DUSP8_ENST00000331588.4_Frame_Shift_Del_p.RG602fs	NM_004420.2	NP_004411.2	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	602					inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(1)|lung(2)|prostate(1)|urinary_tract(1)	5		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		AGCTCCTCGCCGCGCGCGCGCC	0.752													2	4	---	---	---	---					
ROBO3	64221	broad.mit.edu	37	11	124750448	124750453	+	In_Frame_Del	DEL	CGGAGT	CGGAGT	-	rs55725290		TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr11:124750448_124750453delCGGAGT	ENST00000397801.1	+	27	4285_4290	c.4093_4098delCGGAGT	c.(4093-4098)del	p.RS1367del	ROBO3_ENST00000543966.1_In_Frame_Del_p.RS130del|ROBO3_ENST00000538940.1_In_Frame_Del_p.RS1345del|ROBO3_ENST00000525482.1_3'UTR	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	1367					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		TGgccggagccggagtcggagtcaga	0.660													4	8	---	---	---	---					
MESP2	145873	broad.mit.edu	37	15	90320121	90320144	+	In_Frame_Del	DEL	AGGGGCAGGGGCAAGGGCAGGGGC	AGGGGCAGGGGCAAGGGCAGGGGC	-	rs56192595		TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr15:90320121_90320144delAGGGGCAGGGGCAAGGGCAGGGGC	ENST00000341735.3	+	1	533_556	c.533_556delAGGGGCAGGGGCAAGGGCAGGGGC	c.(532-558)gag>g	p.EGQGQGQGQ178del	MESP2_ENST00000558723.1_Intron|MESP2_ENST00000560219.1_Intron	NM_001039958.1	NP_001035047.1	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog (mouse)	178					Notch signaling pathway	nucleus	DNA binding	p.Q198_G205delQGQGQGQG(1)		kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			ACGCaggcggaggggcaggggcaagggcaggggcaggggcaggg	0.777													6	4	---	---	---	---					
CAPN15	6650	broad.mit.edu	37	16	597209	597214	+	In_Frame_Del	DEL	AGGACA	AGGACA	-			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr16:597209_597214delAGGACA	ENST00000219611.2	+	4	734_739	c.371_376delAGGACA	c.(370-378)gag>g	p.EDK124del	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		GGGCAGTGCgaggacaaggacgagga	0.714													3	6	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74378976	74378976	+	RNA	DEL	T	T	-	rs35591542		TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr16:74378976delT	ENST00000429810.2	-	0	1086																											ACCTCTTGAAttttttttttt	0.418													2	4	---	---	---	---					
TBC1D3P2	440452	broad.mit.edu	37	17	60347260	60347260	+	RNA	DEL	T	T	-	rs71816198		TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr17:60347260delT	ENST00000581291.1	-	0	581																				breast(2)|kidney(1)|lung(2)	5						CTCTGAATGATTTTTTTTTTT	0.448													4	3	---	---	---	---					
TNFSF9	8744	broad.mit.edu	37	19	6531149	6531151	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr19:6531149_6531151delGCT	ENST00000245817.3	+	1	140_142	c.102_104delGCT	c.(100-105)ggg>gg	p.GL34del		NM_003811.3	NP_003802.1	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily, member 9	34					apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	5						TGGTCGCGGGgctgctgctgctg	0.768													9	75	---	---	---	---					
SUGP2	10147	broad.mit.edu	37	19	19136394	19136394	+	Frame_Shift_Del	DEL	T	T	-			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr19:19136394delT	ENST00000601879.1	-	3	1060	c.763delA	c.(763-765)tafs	p.I255fs	SUGP2_ENST00000337018.6_Frame_Shift_Del_p.I255fs|SUGP2_ENST00000452918.2_Frame_Shift_Del_p.I255fs|SUGP2_ENST00000600377.1_Frame_Shift_Del_p.I269fs|SUGP2_ENST00000456085.2_Intron|SUGP2_ENST00000598202.1_5'UTR			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	255					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						ACGGTGGGTATTTTTTTTGTG	0.502													7	225	---	---	---	---					
CTC-260E6.6	0	broad.mit.edu	37	19	20359846	20359847	+	RNA	DEL	GT	GT	-			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr19:20359846_20359847delGT	ENST00000593655.1	-	0	199																											TTAAGTAAAGGTGTGTGTGTGT	0.421													8	167	---	---	---	---					
TRIOBP	11078	broad.mit.edu	37	22	38120029	38120031	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr22:38120029_38120031delCCT	ENST00000406386.3	+	7	1721_1723	c.1466_1468delCCT	c.(1465-1470)gcc>g	p.AS489del	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	489					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AATCCCAGAGCCTCCTCTCCCAG	0.601													14	353	---	---	---	---					
RANGAP1	5905	broad.mit.edu	37	22	41650469	41650471	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-97-8177-01A-11D-2284-08	TCGA-97-8177-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d0aee258-a42e-4e90-a4e2-cd6a1b437915	f9d419fc-603b-44bb-964c-1d80d0dddb6b	g.chr22:41650469_41650471delTCC	ENST00000455915.2	-	10	2570_2572	c.1101_1103delGGA	c.(1099-1104)gaa>ga	p.EE367del	RANGAP1_ENST00000405486.1_In_Frame_Del_p.EE367del|RANGAP1_ENST00000356244.3_In_Frame_Del_p.EE367del|RANGAP1_ENST00000407260.4_In_Frame_Del_p.EE312del			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	367	Asp/Glu-rich (highly acidic).				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ctcttctccttcctcctcctcct	0.562													9	275	---	---	---	---