Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPR173	54328	broad.mit.edu	37	X	53106254	53106254	+	Missense_Mutation	SNP	T	T	C			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chrX:53106254T>C	ENST00000332582.4	+	2	942	c.451T>C	c.(451-453)Tct>Cct	p.S151P		NM_018969.5	NP_061842.1	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	151						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)	16						CTGGACCCTGTCTGTGGCCAT	0.587000													4	31					0	0	1	0	0
PPL	5493	broad.mit.edu	37	16	4935331	4935331	+	Missense_Mutation	SNP	C	C	G	rs145520571		TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr16:4935331C>G	ENST00000345988.2	-	22	3414	c.3325G>C	c.(3325-3327)Gag>Cag	p.E1109Q	PPL_ENST00000590782.2_Missense_Mutation_p.E1107Q	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	1109					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						ATCTTGCCCTCGGCCATGGCC	0.632000													6	102					0	0	1	0	0
CAAP1	79886	broad.mit.edu	37	9	26842344	26842344	+	Silent	SNP	C	C	G			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr9:26842344C>G	ENST00000333916.5	-	6	1129	c.1041G>C	c.(1039-1041)gcG>gcC	p.A347A	CAAP1_ENST00000535437.1_Silent_p.A202A|CAAP1_ENST00000520187.1_3'UTR	NM_001167575.1|NM_024828.3	NP_001161047.1|NP_079104.3	Q9H8G2	CI082_HUMAN	caspase activity and apoptosis inhibitor 1	347																	GGGCTTTAATCGCTCTTGCCC	0.428000													4	56					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580953	140580953	+	Missense_Mutation	SNP	C	C	G			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr5:140580953C>G	ENST00000354757.3	+	1	1606	c.1606C>G	c.(1606-1608)Cgc>Ggc	p.R536G	PCDHB11_ENST00000536699.1_Missense_Mutation_p.R171G	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		536	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGCCACAGACCGCGGCTCCCC	0.667000													11	177					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871076	170871076	+	Silent	SNP	G	G	A			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr6:170871076G>A	ENST00000392092.2	+	3	531	c.252G>A	c.(250-252)caG>caA	p.Q84Q	TBP_ENST00000540980.1_Silent_p.Q64Q|TBP_ENST00000230354.6_Silent_p.Q84Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	84	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q84Q(2)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.602000													6	73					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1585397	1585397	+	Missense_Mutation	SNP	T	T	C	rs148754551	by1000genomes	TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr20:1585397T>C	ENST00000279477.7	-	3	806	c.742A>G	c.(742-744)Acc>Gcc	p.T248A	SIRPB1_ENST00000381605.4_Intron|SIRPB1_ENST00000568365.1_Missense_Mutation_p.T248A|SIRPB1_ENST00000381603.3_Intron|RP4-576H24.4_ENST00000564763.1_Intron	NM_001135844.2	NP_001129316.1	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	248					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.T248A(5)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CCTCGGATGGTCTCAGACAAG	0.627000													8	42					0	0	1	0	0
ZNF587B	100293516	broad.mit.edu	37	19	58352292	58352292	+	Missense_Mutation	SNP	A	A	G	rs2562053		TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr19:58352292A>G	ENST00000442832.4	+	3	484	c.250A>G	c.(250-252)Aca>Gca	p.T84A	ZNF587B_ENST00000316462.4_Missense_Mutation_p.T83A|ZNF587B_ENST00000594901.1_Missense_Mutation_p.T84A|CTD-2583A14.10_ENST00000598031.1_Intron	NM_001204818.1	NP_001191747.1	B4DR41	B4DR41_HUMAN	zinc finger protein 587B	84					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding										GACTCCTGTGACAGGTGTGTC	0.498000													3	25					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233785120	233785120	+	Missense_Mutation	SNP	C	C	A			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr2:233785120C>A	ENST00000264051.3	-	5	980	c.702G>T	c.(700-702)aaG>aaT	p.K234N	NGEF_ENST00000373552.4_Missense_Mutation_p.K142N|NGEF_ENST00000409079.1_Missense_Mutation_p.K142N	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	234	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GGGGCAGAGTCTTCCTCTCTG	0.602000													4	84					2.56e-06	2.84444e-06	1	1	0
PPP1R3A	5506	broad.mit.edu	37	7	113518262	113518262	+	Missense_Mutation	SNP	C	C	T	rs148408134	byFrequency	TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr7:113518262C>T	ENST00000284601.3	-	4	2953	c.2885G>A	c.(2884-2886)gGt>gAt	p.G962D		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	962					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						CTTCTCAATACCCTGGATTTC	0.403000													3	42					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871043	170871043	+	Silent	SNP	G	G	A			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr6:170871043G>A	ENST00000392092.2	+	3	498	c.219G>A	c.(217-219)caG>caA	p.Q73Q	TBP_ENST00000540980.1_Silent_p.Q53Q|TBP_ENST00000230354.6_Silent_p.Q73Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	73	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q73Q(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcaacagcaacagcagc	0.562000													9	64					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103063627	103063627	+	Silent	SNP	G	G	T			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr2:103063627G>T	ENST00000264260.2	+	10	1759	c.1170G>T	c.(1168-1170)ctG>ctT	p.L390L	IL18RAP_ENST00000409369.1_Silent_p.L248L	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	390					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						AAATAGTGCTGCTGTACCGGA	0.577000													8	225					1.58986e-06	1.81699e-06	1	1	0
CPS1	1373	broad.mit.edu	37	2	211532996	211532996	+	Silent	SNP	G	G	C			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr2:211532996G>C	ENST00000233072.5	+	34	4285	c.4089G>C	c.(4087-4089)ctG>ctC	p.L1363L	CPS1_ENST00000451903.2_Silent_p.L912L|CPS1_ENST00000430249.2_Silent_p.L1369L	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1363					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		AAGGCATCCTGATAGGCATCC	0.458000													4	65					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100680859	100680859	+	Silent	SNP	G	G	T			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr7:100680859G>T	ENST00000306151.4	+	3	6226	c.6162G>T	c.(6160-6162)acG>acT	p.T2054T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2054	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCAGCACTACGCTTGTGGTCA	0.493000													8	248					5.68852e-11	6.69238e-11	1	1	0
LILRB1	10859	broad.mit.edu	37	19	55143042	55143042	+	Silent	SNP	G	G	A			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr19:55143042G>A	ENST00000396331.1	+	5	519	c.162G>A	c.(160-162)gaG>gaA	p.E54E	LILRB1_ENST00000434867.2_Silent_p.E54E|LILRB1_ENST00000418536.2_Silent_p.E54E|LILRB1_ENST00000396315.1_Silent_p.E54E|LILRB1_ENST00000396321.2_Silent_p.E54E|LILRB1_ENST00000396332.4_Silent_p.E54E|LILRB1_ENST00000324602.7_Silent_p.E54E|LILRB1_ENST00000396317.1_Silent_p.E54E|LILRB1_ENST00000448689.1_Silent_p.E54E|LILRB1_ENST00000396327.3_Silent_p.E54E|LILRB1_ENST00000427581.2_Silent_p.E90E	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	54	Ig-like C2-type 1.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GGGGCCAGGAGACCCAGGAGT	0.582000										HNSCC(37;0.09)			7	135					0	0	1	0	0
GLB1L2	89944	broad.mit.edu	37	11	134238566	134238566	+	Silent	SNP	G	G	T			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr11:134238566G>T	ENST00000535456.2	+	10	1106	c.918G>T	c.(916-918)gtG>gtT	p.V306V	GLB1L2_ENST00000529077.1_3'UTR|GLB1L2_ENST00000389881.3_Silent_p.V306V|GLB1L2_ENST00000339772.7_Silent_p.V306V	NM_138342.3	NP_612351.2	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2	306					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CTGCCATTGTGGACGCCGGCT	0.527000													5	57					0.184627	0.189361	1	1	0
CAPN6	827	broad.mit.edu	37	X	110495622	110495622	+	Silent	SNP	G	G	A			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chrX:110495622G>A	ENST00000324068.1	-	5	779	c.612C>T	c.(610-612)taC>taT	p.Y204Y	CAPN6_ENST00000541758.1_Intron	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	204	Calpain catalytic.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						CAAGCTCAGTGTATCTTCCTT	0.438000													4	29					0	0	1	0	0
MMP27	64066	broad.mit.edu	37	11	102565727	102565727	+	Missense_Mutation	SNP	T	T	A			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr11:102565727T>A	ENST00000260229.4	-	7	1095	c.1004A>T	c.(1003-1005)aAc>aTc	p.N335I		NM_022122.2	NP_071405.2	Q9H306	MMP27_HUMAN	matrix metallopeptidase 27	335	Hemopexin-like 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.N335I(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(12)|ovary(2)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		ATCTCTGGGGTTCTCGTATGC	0.448000													4	39					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453124	140453124	+	Missense_Mutation	SNP	C	C	A			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr7:140453124C>A	ENST00000288602.6	-	15	1871	c.1811G>T	c.(1810-1812)tGg>tTg	p.W604L		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	604	Protein kinase.				activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.W604*(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.V600_S605>EK(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	GGACCCACTCCATCGAGATTT	0.388000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				3	30					1	1	1	1	0
ZSCAN5B	342933	broad.mit.edu	37	19	56704080	56704080	+	Missense_Mutation	SNP	G	G	T			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr19:56704080G>T	ENST00000586855.2	-	2	655	c.342C>A	c.(340-342)gaC>gaA	p.D114E	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.D114E			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	114	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						GGTCCTCCAGGTCTTTGCAGC	0.547000													4	64					0.00024832	0.000268454	1	1	0
BMS1P20	96610	broad.mit.edu	37	22	22664056	22664056	+	RNA	SNP	T	T	C	rs3178309		TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr22:22664056T>C	ENST00000426066.1	+	0	623					NR_027293.1																						ATAAAGTATATGATTTTGTGT	0.348000													4	33					0	0	1	0	0
GAB4	128954	broad.mit.edu	37	22	17450878	17450878	+	Missense_Mutation	SNP	C	C	A			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr22:17450878C>A	ENST00000400588.1	-	4	999	c.892G>T	c.(892-894)Ggc>Tgc	p.G298C	GAB4_ENST00000523144.1_Intron	NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	298										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				CTGGTGTGGCCATGGGAGGCC	0.597000													6	154					0.00116845	0.00122994	1	1	0
TBP	6908	broad.mit.edu	37	6	170871082	170871082	+	Silent	SNP	G	G	A			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr6:170871082G>A	ENST00000392092.2	+	3	537	c.258G>A	c.(256-258)caG>caA	p.Q86Q	TBP_ENST00000540980.1_Silent_p.Q66Q|TBP_ENST00000230354.6_Silent_p.Q86Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	86	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q86Q(2)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.612000													10	70					0	0	1	0	0
HOXA7	3204	broad.mit.edu	37	7	27194807	27194807	+	Silent	SNP	C	C	G			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr7:27194807C>G	ENST00000242159.3	-	2	547	c.414G>C	c.(412-414)acG>acC	p.T138T	HOXA7_ENST00000523796.2_5'UTR|HOXA-AS3_ENST00000518947.2_RNA	NM_006896.3	NP_008827.2	P31268	HXA7_HUMAN	homeobox A7	138					angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding			endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|urinary_tract(1)	16						TCTGGTAGCGCGTGTAGGTCT	0.607000													9	126					0	0	1	0	0
MAGEA6	4105	broad.mit.edu	37	X	151869808	151869808	+	Silent	SNP	G	G	C			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chrX:151869808G>C	ENST00000329342.5	+	3	723	c.498G>C	c.(496-498)ctG>ctC	p.L166L		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	166	MAGE.						protein binding			breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GCATCGAGCTGATGGAAGTGG	0.542000													8	107					0	0	1	0	0
FLJ33360	401172	broad.mit.edu	37	5	6337066	6337067	+	RNA	DEL	AC	AC	-			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr5:6337066_6337067delAC	ENST00000507444.1	-	0	143					NR_028351.1																						acacatacatacacacacacac	0.475													2	4	---	---	---	---					
PCDHB8	56128	broad.mit.edu	37	5	140559076	140559076	+	Frame_Shift_Del	DEL	C	C	-			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr5:140559076delC	ENST00000239444.2	+	1	1706	c.1461delC	c.(1459-1461)gtfs	p.V487fs		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		487	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGCCCAGGTCACCTACTCGC	0.657													9	504	---	---	---	---					
PHF14	9678	broad.mit.edu	37	7	11082342	11082342	+	Frame_Shift_Del	DEL	A	A	-			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr7:11082342delA	ENST00000403050.3	+	13	2665	c.2213delA	c.(2212-2214)ctfs	p.H738fs	PHF14_ENST00000445996.2_Frame_Shift_Del_p.H453fs	NM_014660.3	NP_055475.2	O94880	PHF14_HUMAN	PHD finger protein 14	738							zinc ion binding			NS(2)|breast(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	35				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		CATGATCAGCATCTTCTTTTA	0.338													2	4	---	---	---	---					
ZAN	7455	broad.mit.edu	37	7	100369720	100369721	+	RNA	INS	-	-	T			TCGA-L4-A4E6-01A-11D-A24D-08	TCGA-L4-A4E6-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2dae3b0-daed-439d-a376-38b637cc16de	029290ef-d50f-4821-ab73-8e05ab4a233c	g.chr7:100369720_100369721insT	ENST00000542585.1	+	0	5573				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			cctctaaattcttttttttttt	0.535													5	6	---	---	---	---