Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GALNT1	2589	broad.mit.edu	37	18	33272258	33272258	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr18:33272258C>T	ENST00000269195.5	+	8	1376	c.1273C>T	c.(1273-1275)Cca>Tca	p.P425S	GALNT1_ENST00000537549.1_Missense_Mutation_p.P365S	NM_020474.3	NP_065207.2	Q10472	GALT1_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)	425					protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(4)|stomach(1)	21						TTCTCAAATTCCACGTCACTA	0.294000													4	72					0	0	1	0	0
DDX27	55661	broad.mit.edu	37	20	47839913	47839913	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr20:47839913G>T	ENST00000371764.4	+	4	511	c.502G>T	c.(502-504)Gat>Tat	p.D168Y	DDX27_ENST00000484427.1_3'UTR	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	168	Asp/Glu/Lys-rich.					nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			AGGCTCAGAAGATGAAGCCTC	0.498000													9	109					0.00448238	0.00470398	1	1	0
FAM90A1	55138	broad.mit.edu	37	12	8375360	8375360	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:8375360C>T	ENST00000538603.1	-	7	1011	c.453G>A	c.(451-453)ccG>ccA	p.P151P	FAM90A1_ENST00000307435.6_Silent_p.P151P	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	151							nucleic acid binding|zinc ion binding	p.P151P(1)		endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		TTGTGTGGACCGGCATTGGCC	0.527000													3	23					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922485	24922485	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr15:24922485G>T	ENST00000329468.2	+	1	1945	c.1471G>T	c.(1471-1473)Gcg>Tcg	p.A491S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CGTAGGAGCAGCGCCTCTCAC	0.522000													19	184					5.35267e-07	6.2649e-07	1	1	0
AIPL1	23746	broad.mit.edu	37	17	6328971	6328971	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:6328971G>A	ENST00000381129.3	-	6	1044	c.964C>T	c.(964-966)Cgc>Tgc	p.R322C	AIPL1_ENST00000574506.1_Missense_Mutation_p.R310C|AIPL1_ENST00000576776.1_Missense_Mutation_p.R298C|AIPL1_ENST00000250087.5_Missense_Mutation_p.R259C|AIPL1_ENST00000575265.1_3'UTR|AIPL1_ENST00000576307.1_Missense_Mutation_p.R262C|AIPL1_ENST00000570466.1_Missense_Mutation_p.R300C	NM_001033055.1|NM_014336.3	NP_001028227.1|NP_055151.3	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting protein-like 1	322					protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	12				COAD - Colon adenocarcinoma(228;0.141)		TTCCGGCAGCGCAGCCGCTCC	0.672000													8	52					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216284084	216284084	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:216284084C>A	ENST00000354785.4	-	12	2069	c.1700G>T	c.(1699-1701)gGg>gTg	p.G567V	FN1_ENST00000443816.1_Missense_Mutation_p.G567V|FN1_ENST00000421182.1_Missense_Mutation_p.G567V|FN1_ENST00000357867.4_Missense_Mutation_p.G567V|FN1_ENST00000345488.5_Missense_Mutation_p.G567V|FN1_ENST00000357009.2_Missense_Mutation_p.G567V|FN1_ENST00000323926.6_Missense_Mutation_p.G567V|FN1_ENST00000432072.2_Missense_Mutation_p.G567V|FN1_ENST00000426059.1_Missense_Mutation_p.G567V|FN1_ENST00000446046.1_Missense_Mutation_p.G567V|FN1_ENST00000346544.3_Missense_Mutation_p.G567V|FN1_ENST00000359671.1_Missense_Mutation_p.G567V|FN1_ENST00000356005.4_Missense_Mutation_p.G567V|FN1_ENST00000336916.4_Missense_Mutation_p.G567V			P02751	FINC_HUMAN	fibronectin 1	567	Collagen-binding.|Fibronectin type-I 9.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATAAAACGTCCCAGTCTCTGA	0.433000													5	56					0.0215528	0.0219763	1	1	0
OR2F2	135948	broad.mit.edu	37	7	143632906	143632906	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:143632906C>T	ENST00000408955.2	+	1	648	c.581C>T	c.(580-582)tCc>tTc	p.S194F		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					GACACCTCCTCCAATGAGGCT	0.488000													20	83					0	0	1	0	0
LCMT2	9836	broad.mit.edu	37	15	43622606	43622606	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr15:43622606C>G	ENST00000305641.5	-	1	197	c.82G>C	c.(82-84)Gcc>Ccc	p.A28P	LCMT2_ENST00000544735.1_5'UTR|LCMT2_ENST00000567039.1_Missense_Mutation_p.A28P	NM_014793.4	NP_055608.2	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	28					tRNA processing		methyltransferase activity|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|liver(1)|lung(9)|skin(1)|urinary_tract(1)	20		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	CCGCGCGCGGCCAGGGAACGC	0.706000													7	26					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50051844	50051844	+	Silent	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:50051844C>A	ENST00000376042.1	+	6	973	c.675C>A	c.(673-675)acC>acA	p.T225T	CCNB3_ENST00000376038.1_Intron|CCNB3_ENST00000348603.2_Intron|CCNB3_ENST00000276014.7_Silent_p.T225T			Q8WWL7	CCNB3_HUMAN	cyclin B3	225					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					CAGCCATCACCAAGAAGACAT	0.473000													6	45					3.59834e-05	4.01056e-05	1	1	0
MAP2	4133	broad.mit.edu	37	2	210558582	210558582	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:210558582A>G	ENST00000360351.4	+	7	2194	c.1688A>G	c.(1687-1689)tAt>tGt	p.Y563C	MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.Y559C|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000361559.4_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	563					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	ATGCCATTTTATGAAGATAAA	0.378000													43	70					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179606632	179606632	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:179606632A>T	ENST00000589042.1	-	48	11552	c.11328T>A	c.(11326-11328)ttT>ttA	p.F3776L	TTN_ENST00000591111.1_Missense_Mutation_p.F3459L|TTN_ENST00000359218.5_Missense_Mutation_p.F3538L|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.F3605L|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.F3413L|TTN_ENST00000342992.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3459							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGCAGACAGAAAAGAACTAG	0.299000													3	4					0	0	1	0	0
DYRK1A	1859	broad.mit.edu	37	21	38884454	38884454	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr21:38884454A>T	ENST00000339659.3	+	11	3355	c.1885A>T	c.(1885-1887)Aat>Tat	p.N629Y	DYRK1A_ENST00000398960.2_Missense_Mutation_p.N638Y|DYRK1A_ENST00000455387.2_Missense_Mutation_p.N410Y|DYRK1A_ENST00000338785.3_3'UTR	NM_130436.2	NP_569120.1	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	638					nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			breast(4)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						TTCTCCAACGAATAGCTCCTC	0.532000													7	42					0	0	1	0	0
OLFM4	10562	broad.mit.edu	37	13	53624181	53624181	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr13:53624181C>A	ENST00000219022.2	+	5	886	c.808C>A	c.(808-810)Cta>Ata	p.L270I		NM_006418.4	NP_006409.3	Q6UX06	OLFM4_HUMAN	olfactomedin 4	270	Olfactomedin-like.				cell adhesion	extracellular space				breast(2)|endometrium(4)|kidney(4)|large_intestine(5)|lung(20)|skin(3)|urinary_tract(1)	39		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		GTTTTCTTATCTATATGGTGC	0.453000													16	66					2.32078e-09	2.82978e-09	1	1	0
CIT	11113	broad.mit.edu	37	12	120210636	120210636	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:120210636C>T	ENST00000392521.2	-	17	2075	c.2020G>A	c.(2020-2022)Gag>Aag	p.E674K	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Missense_Mutation_p.E674K	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	674					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGCAGCTTCTCCAGCTCCCTC	0.592000													48	138					0	0	1	0	0
SPPL3	121665	broad.mit.edu	37	12	121206210	121206210	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:121206210G>C	ENST00000353487.2	-	8	1194	c.691C>G	c.(691-693)Cta>Gta	p.L231V		NM_139015.4	NP_620584.2	Q8TCT6	PSL4_HUMAN	signal peptide peptidase like 3	232						integral to membrane	aspartic-type endopeptidase activity					all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TTCCGGGATAGAACGTCAAGG	0.537000													10	166					0	0	1	0	0
PHIP	55023	broad.mit.edu	37	6	79650952	79650952	+	Nonsense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:79650952T>A	ENST00000275034.4	-	40	5091	c.4924A>T	c.(4924-4926)Aaa>Taa	p.K1642*	PHIP_ENST00000479165.1_5'UTR	NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	1642					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		ACTTTAGGTTTCCTTCCAGGT	0.403000													21	87					0	0	1	0	0
STK17B	9262	broad.mit.edu	37	2	197028013	197028013	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:197028013T>C	ENST00000263955.4	-	2	381	c.95A>G	c.(94-96)tAt>tGt	p.Y32C	STK17B_ENST00000409228.1_Missense_Mutation_p.Y32C	NM_004226.3	NP_004217.1	O94768	ST17B_HUMAN	serine/threonine kinase 17b	32					apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(2)|large_intestine(1)|lung(10)	15			OV - Ovarian serous cystadenocarcinoma(117;0.141)			TGTAAGTATATAGAAATTATT	0.318000													51	59					0	0	1	0	0
MFAP3L	9848	broad.mit.edu	37	4	170913201	170913201	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:170913201G>A	ENST00000361618.3	-	3	865	c.558C>T	c.(556-558)atC>atT	p.I186I	RP11-6E9.4_ENST00000508955.1_RNA|MFAP3L_ENST00000393704.3_Silent_p.I83I	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	186						integral to membrane|plasma membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		AGAACTCATTGATGGCCTTCT	0.522000													9	106					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64415927	64415927	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:64415927G>T	ENST00000262043.3	+	12	3716	c.3376G>T	c.(3376-3378)Gca>Tca	p.A1126S	PHF3_ENST00000393387.1_Missense_Mutation_p.A1126S			Q92576	PHF3_HUMAN	PHD finger protein 3	1126					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AGGTCGAATGGCACCACCTGT	0.353000													3	36					0.115264	0.116764	1	1	0
DHX16	8449	broad.mit.edu	37	6	30633346	30633346	+	Silent	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:30633346C>A	ENST00000376442.3	-	5	1026	c.831G>T	c.(829-831)cgG>cgT	p.R277R		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	277					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			kidney(2)|ovary(2)	4						GGGCGAGATCCCGCACTCGCC	0.627000													6	68					0.000157383	0.000171324	1	1	0
RP1L1	94137	broad.mit.edu	37	8	10466057	10466057	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:10466057C>A	ENST00000382483.3	-	4	5774	c.5551G>T	c.(5551-5553)Gta>Tta	p.V1851L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1851					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GGGGCCTCTACACCTTCTGAC	0.642000													33	139					3.11337e-16	4.13053e-16	1	1	0
PRAMEF12	390999	broad.mit.edu	37	1	12835253	12835253	+	Silent	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:12835253G>T	ENST00000357726.4	+	1	270	c.243G>T	c.(241-243)gtG>gtT	p.V81V		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	81										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTCGAGCTGTGCTGGAGGGGC	0.587000													7	82					8.12818e-05	8.91047e-05	1	1	0
LONP1	9361	broad.mit.edu	37	19	5705926	5705926	+	Silent	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:5705926G>C	ENST00000360614.3	-	8	1381	c.1224C>G	c.(1222-1224)ggC>ggG	p.G408G	LONP1_ENST00000590729.1_Silent_p.G278G|LONP1_ENST00000540670.2_Silent_p.G212G|LONP1_ENST00000585374.1_Silent_p.G294G|LONP1_ENST00000593119.1_Silent_p.G344G	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	408					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CCTTCTCCAGGCCCAGCTCCT	0.582000													19	72					0	0	1	0	0
RCBTB2	1102	broad.mit.edu	37	13	49089420	49089420	+	Silent	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr13:49089420C>G	ENST00000344532.3	-	6	693	c.270G>C	c.(268-270)cgG>cgC	p.R90R	RCBTB2_ENST00000544492.1_5'UTR|RCBTB2_ENST00000481144.1_5'UTR|RCBTB2_ENST00000430805.2_Silent_p.R95R|RCBTB2_ENST00000544904.1_Silent_p.R66R	NM_001268.2	NP_001259.1	O95199	RCBT2_HUMAN	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	90							Ran guanyl-nucleotide exchange factor activity			breast(5)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(3)	31		all_cancers(8;4.86e-71)|all_epithelial(8;2.11e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;2.3e-10)|Lung NSC(96;1.07e-07)|Breast(56;1.53e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.00826)|Myeloproliferative disorder(33;0.0179)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(99;1.8e-09)|LUSC - Lung squamous cell carcinoma(3;0.116)		AATCCAGTCTCCGAGGTTCAA	0.463000													9	135					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	16006318	16006318	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:16006318G>A	ENST00000221700.5	-	3	436	c.341C>T	c.(340-342)tCa>tTa	p.S114L	CYP4F2_ENST00000592328.1_Intron|CYP4F2_ENST00000011989.7_Intron	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	114					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GATGGTACCTGAGGCGTTGAT	0.607000													10	155					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62849323	62849323	+	Splice_Site	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:62849323T>A	ENST00000512091.1	+	18	3779		c.e18+2		LPHN3_ENST00000514157.1_Splice_Site|LPHN3_ENST00000511324.1_Splice_Site|LPHN3_ENST00000507625.1_Splice_Site|LPHN3_ENST00000504896.1_Splice_Site|LPHN3_ENST00000506720.1_Splice_Site|LPHN3_ENST00000509896.1_Splice_Site|LPHN3_ENST00000508946.1_Splice_Site|LPHN3_ENST00000545650.1_Splice_Site|LPHN3_ENST00000508693.1_Splice_Site|LPHN3_ENST00000507164.1_Splice_Site|LPHN3_ENST00000514591.1_Splice_Site|LPHN3_ENST00000506746.1_Splice_Site|LPHN3_ENST00000514996.1_Splice_Site|LPHN3_ENST00000506700.1_Splice_Site			Q9HAR2	LPHN3_HUMAN	latrophilin 3						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						AGATAAAGTGTAAGTTTATTG	0.383000													6	89					0	0	1	0	0
TRBV7-1	28597	broad.mit.edu	37	7	142032484	142032484	+	RNA	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:142032484C>A	ENST00000547918.2	+	0	337																											CCAGCGCACACAGCAGGGGGA	0.562000													12	16					7.03913e-09	8.47235e-09	1	1	0
AGAP11	119385	broad.mit.edu	37	10	88764085	88764085	+	RNA	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:88764085G>C	ENST00000444431.1	+	0	2627				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										TCCACAGTGTGACCTTGGAGA	0.378000													11	175					0	0	1	0	0
UGT2B7	7364	broad.mit.edu	37	4	69973927	69973927	+	Silent	SNP	A	A	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:69973927A>G	ENST00000305231.7	+	5	1243	c.1197A>G	c.(1195-1197)caA>caG	p.Q399Q	UGT2B7_ENST00000509763.1_Intron|UGT2B7_ENST00000508661.1_Intron	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	399					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TTGCCGATCAACCTGATAACA	0.468000													10	131					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92365217	92365217	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:92365217T>C	ENST00000276609.3	+	11	1546	c.1307T>C	c.(1306-1308)aTc>aCc	p.I436T	SLC26A7_ENST00000523719.1_Missense_Mutation_p.I436T|SLC26A7_ENST00000309536.2_Missense_Mutation_p.I436T|SLC26A7_ENST00000520249.1_3'UTR	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	436						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			GTGGATAAAATCGATTGGGTA	0.308000													23	62					0	0	1	0	0
EVC	2121	broad.mit.edu	37	4	5733209	5733209	+	Silent	SNP	T	T	C	rs139931919	byFrequency	TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:5733209T>C	ENST00000382674.2	+	4	626	c.442T>C	c.(442-444)Ttg>Ctg	p.L148L	EVC_ENST00000264956.6_Silent_p.L148L|EVC_ENST00000509451.1_Silent_p.L148L			P57679	EVC_HUMAN	Ellis van Creveld syndrome	148					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				GCAGGCTGTTTTGCCACACCA	0.602000													5	86					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16419110	16419110	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:16419110C>G	ENST00000380672.4	-	7	3234	c.3177G>C	c.(3175-3177)ttG>ttC	p.L1059F	BNC2_ENST00000380667.2_Missense_Mutation_p.L992F|BNC2_ENST00000545497.1_Missense_Mutation_p.L964F	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	1059					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		GCATTTCTCTCAAATGCACAG	0.463000													4	69					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4511063	4511063	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:4511063C>T	ENST00000301286.3	-	3	2866	c.2867G>A	c.(2866-2868)gGg>gAg	p.G956E		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	956	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						ATTCACTGCCCCCGTGACTCC	0.592000													11	44					0	0	1	0	0
PLD1	5337	broad.mit.edu	37	3	171417558	171417558	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:171417558C>T	ENST00000356327.5	-	12	1274	c.1204G>A	c.(1204-1206)Gac>Aac	p.D402N	PLD1_ENST00000342215.6_Missense_Mutation_p.D402N|PLD1_ENST00000340989.4_Missense_Mutation_p.D402N|PLD1_ENST00000351298.4_Missense_Mutation_p.D402N	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	402					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	AGAATGCAGTCCAACCTCCAA	0.368000													15	303					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49696497	49696497	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:49696497C>A	ENST00000433368.2	-	8	822	c.753G>T	c.(751-753)caG>caT	p.Q251H	CRISP3_ENST00000393666.1_Missense_Mutation_p.Q228H|CRISP3_ENST00000423399.2_Missense_Mutation_p.Q138H|CRISP3_ENST00000263045.4_Missense_Mutation_p.Q241H|CRISP3_ENST00000371159.4_Missense_Mutation_p.Q259H	NM_001190986.1	NP_001177915.1	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3	228					innate immune response	proteinaceous extracellular matrix|specific granule				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|skin(6)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CCCTGACCAACTGATGTTTAC	0.388000													24	104					9.57634e-11	1.21857e-10	1	1	0
RAD51D	5892	broad.mit.edu	37	17	33434396	33434396	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:33434396C>A	ENST00000345365.6	-	4	589	c.334G>T	c.(334-336)Ggc>Tgc	p.G112C	RAD51D_ENST00000590380.1_5'UTR|RAD51D_ENST00000460118.2_Intron|RAD51D_ENST00000590016.1_Missense_Mutation_p.G132C|RAD51D_ENST00000360276.3_Missense_Mutation_p.G112C|RAD51D_ENST00000394589.4_Missense_Mutation_p.G112C|RAD51L3-RFFL_ENST00000593039.1_Intron|RAD51D_ENST00000335858.7_Intron	NM_002878.3	NP_002869.3	O75771	RA51D_HUMAN	RAD51 paralog D	112					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|liver(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						TGAGTTTTGCCGCTACCTGGG	0.502000								Direct reversal of damage					9	45					0.00621372	0.00644846	1	1	0
NCOA6	23054	broad.mit.edu	37	20	33345057	33345057	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr20:33345057G>C	ENST00000374796.2	-	8	4064	c.1494C>G	c.(1492-1494)aaC>aaG	p.N498K	NCOA6_ENST00000359003.2_Missense_Mutation_p.N498K			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	498	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						GTGGCCCCTGGTTTGGTGGTT	0.493000													27	95					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821329	5821329	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:5821329C>T	ENST00000381095.3	-	5	2017	c.1390G>A	c.(1390-1392)Ggc>Agc	p.G464S	NLGN4X_ENST00000538097.1_Missense_Mutation_p.G464S|NLGN4X_ENST00000381093.2_Missense_Mutation_p.G484S|NLGN4X_ENST00000275857.6_Missense_Mutation_p.G464S|NLGN4X_ENST00000381092.1_Missense_Mutation_p.G464S	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	464					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						GTGGGGGAGCCGTACTGCGCG	0.612000													12	19					0	0	1	0	0
DPY19L2	283417	broad.mit.edu	37	12	64061838	64061838	+	Splice_Site	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:64061838G>A	ENST00000324472.4	-	1	519	c.337_splice	c.e1+1	p.I112_splice	RP11-415I12.3_ENST00000509615.2_RNA	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	112					multicellular organismal development|spermatid development	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TCTCCTCACCGATGCCGAGAG	0.592000													8	79					0	0	1	0	0
ZAK	51776	broad.mit.edu	37	2	174085953	174085953	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:174085953G>C	ENST00000338983.3	+	12	1258	c.1063G>C	c.(1063-1065)Gag>Cag	p.E355Q	MLTK_ENST00000375213.3_Intron|MLTK_ENST00000539448.1_Missense_Mutation_p.E355Q|MLK7-AS1_ENST00000423106.2_RNA|MLTK_ENST00000409176.2_Intron|MLTK_ENST00000431503.2_Missense_Mutation_p.E254Q|MLK7-AS1_ENST00000422703.1_RNA	NM_133646.2	NP_598407.1																					AAACAGTGCAGAGATGTCATG	0.473000													14	70					0	0	1	0	0
SLC1A7	6512	broad.mit.edu	37	1	53553735	53553735	+	Silent	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:53553735A>T	ENST00000371494.4	-	11	1756	c.1629T>A	c.(1627-1629)gcT>gcA	p.A543A	SLC1A7_ENST00000488036.1_5'UTR	NM_006671.4	NP_006662.3	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter), member 7	543						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	TCAGACTCGCAGCGGGCAGCT	0.662000													10	30					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86872977	86872977	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:86872977C>A	ENST00000373119.4	+	4	915	c.770C>A	c.(769-771)gCt>gAt	p.A257D	KLHL4_ENST00000373114.4_Missense_Mutation_p.A257D	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	257						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						AGTTTGCTGGCTGCAGCTTGT	0.388000													6	21					3.59834e-05	4.01056e-05	1	1	0
SCN8A	6334	broad.mit.edu	37	12	52139713	52139713	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:52139713G>C	ENST00000354534.5	+	13	2203	c.2025G>C	c.(2023-2025)aaG>aaC	p.K675N	SCN8A_ENST00000545061.1_Missense_Mutation_p.K675N|SCN8A_ENST00000550891.1_Missense_Mutation_p.K675N	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	675					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AAATTAAGAAGAAAGGCCCTG	0.373000													4	30					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325651	31325651	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr18:31325651C>T	ENST00000269197.5	+	12	5839	c.5839C>T	c.(5839-5841)Ctg>Ttg	p.L1947L		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1947					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TACTGCAGCTCTGTTACAGGC	0.532000													6	88					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24463630	24463630	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:24463630G>C	ENST00000270800.1	-	3	384	c.346C>G	c.(346-348)Ctg>Gtg	p.L116V		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	116						integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		CTGTGCTGCAGAGAGCTGAAC	0.622000													3	32					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20344899	20344899	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:20344899G>T	ENST00000298642.2	+	1	509	c.473G>T	c.(472-474)aGt>aTt	p.S158I		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	158					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATTCAATGAGTCAGGTCATA	0.488000													61	189					9.53978e-28	1.31807e-27	1	1	0
PAPPA2	60676	broad.mit.edu	37	1	176659498	176659498	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:176659498C>G	ENST00000367662.3	+	5	3527	c.2363C>G	c.(2362-2364)cCc>cGc	p.P788R	PAPPA2_ENST00000367661.3_Missense_Mutation_p.P788R	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	788					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GAACCAGAGCCCACTAGTGAC	0.562000													31	98					0	0	1	0	0
CISH	1154	broad.mit.edu	37	3	50645412	50645412	+	Missense_Mutation	SNP	C	C	A	rs143405439		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:50645412C>A	ENST00000443053.2	-	4	681	c.454G>T	c.(454-456)Gac>Tac	p.D152Y	CISH_ENST00000348721.3_Missense_Mutation_p.D135Y	NM_013324.5	NP_037456.5	Q9NSE2	CISH_HUMAN	cytokine inducible SH2-containing protein	135	SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of cell growth	intracellular				breast(2)|lung(1)|stomach(1)|upper_aerodigestive_tract(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		AAGCTGGAGTCGGCATACTCA	0.577000													4	53					0.00909568	0.00939753	1	1	0
LAMA2	3908	broad.mit.edu	37	6	129468137	129468137	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:129468137G>A	ENST00000421865.2	+	6	902	c.853G>A	c.(853-855)Ggg>Agg	p.G285R		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	285	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTCAGTTGGAGGGATGTGCAT	0.433000													21	91					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19960535	19960535	+	Silent	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr22:19960535C>A	ENST00000263207.3	-	15	2754	c.2463G>T	c.(2461-2463)gcG>gcT	p.A821A	ARVCF_ENST00000401994.1_Silent_p.A758A|ARVCF_ENST00000406259.1_Silent_p.A815A|ARVCF_ENST00000344269.3_Silent_p.A758A|ARVCF_ENST00000406522.1_Silent_p.A752A	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	821					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					CGTGTGACGCCGCCTTCGCTT	0.682000													6	48					3.59834e-05	4.01056e-05	1	1	0
ZNF256	10172	broad.mit.edu	37	19	58452647	58452647	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:58452647T>A	ENST00000282308.3	-	3	1725	c.1529A>T	c.(1528-1530)cAg>cTg	p.Q510L	ZNF256_ENST00000598928.1_3'UTR	NM_005773.2	NP_005764.2	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	510					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		GTGAACTCTCTGGTGTTGAAG	0.463000													6	76					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103290767	103290767	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:103290767C>G	ENST00000424685.2	-	16	2115	c.1956G>C	c.(1954-1956)tgG>tgC	p.W652C	RELN_ENST00000343529.5_Missense_Mutation_p.W652C|RELN_ENST00000428762.1_Missense_Mutation_p.W652C			P78509	RELN_HUMAN	reelin	652					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGTTTGTCTCCAGCGAATCC	0.438000													7	79					0	0	1	0	0
CPXCR1	53336	broad.mit.edu	37	X	88008501	88008501	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:88008501C>A	ENST00000276127.4	+	3	345	c.86C>A	c.(85-87)aCa>aAa	p.T29K	CPXCR1_ENST00000373111.1_Missense_Mutation_p.T29K	NM_033048.5	NP_149037.4	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	29						intracellular	zinc ion binding			NS(1)|cervix(1)|kidney(1)|large_intestine(11)|liver(1)|lung(20)|ovary(3)|upper_aerodigestive_tract(2)	40						GACTGTAGTACAGACATAGAG	0.423000													8	7					5.18039e-06	5.94409e-06	1	1	0
OTOR	56914	broad.mit.edu	37	20	16729511	16729511	+	Splice_Site	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr20:16729511G>T	ENST00000246081.2	+	2	159		c.e2-1			NM_020157.2	NP_064542.1	Q9NRC9	OTOR_HUMAN	otoraplin						sensory perception of sound	extracellular region				breast(1)|central_nervous_system(1)|endometrium(1)|liver(4)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10						TTTTCTTCCAGATACTATTTC	0.328000													10	11					3.86212e-05	4.2538e-05	1	1	0
PSKH2	85481	broad.mit.edu	37	8	87060869	87060869	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:87060869G>T	ENST00000276616.2	-	3	1054	c.980C>A	c.(979-981)tCt>tAt	p.S327Y		NM_033126.1	NP_149117.1	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	327							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|kidney(11)|large_intestine(2)|lung(26)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(1)	47			STAD - Stomach adenocarcinoma(118;0.129)			CTTCATGGAAGACCCTGCAGC	0.532000													33	88					3.80469e-20	5.18015e-20	1	1	0
FSCB	84075	broad.mit.edu	37	14	44975506	44975506	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:44975506G>C	ENST00000340446.4	-	1	976	c.685C>G	c.(685-687)Ctt>Gtt	p.L229V		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	229						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		TCTTCTAAAAGTACCGGGGGA	0.408000													5	101					0	0	1	0	0
ACKR2	1238	broad.mit.edu	37	3	42907022	42907022	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:42907022C>T	ENST00000422265.1	+	3	1203	c.1028C>T	c.(1027-1029)tCa>tTa	p.S343L	ACKR2_ENST00000442925.1_Missense_Mutation_p.S343L|KRBOX1_ENST00000426937.1_Intron|CYP8B1_ENST00000437102.1_Intron|ACKR2_ENST00000273145.2_Missense_Mutation_p.S343L|ACKR2_ENST00000471537.1_Intron	NM_001296.4	NP_001287.2			atypical chemokine receptor 2																		GCCCAGGCCTCATTATCCAGC	0.547000													10	69					0	0	1	0	0
VANGL2	57216	broad.mit.edu	37	1	160394029	160394029	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:160394029C>A	ENST00000368061.2	+	7	1735	c.1261C>A	c.(1261-1263)Ctg>Atg	p.L421M		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	421					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGAGAGCATCCTGCAGCACCT	0.597000													7	66					0.00198382	0.00209129	1	1	0
CSK	1445	broad.mit.edu	37	15	75093898	75093898	+	Silent	SNP	G	G	A	rs143495597		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr15:75093898G>A	ENST00000220003.9	+	10	1578	c.849G>A	c.(847-849)cgG>cgA	p.R283R	CSK_ENST00000567571.1_Silent_p.R283R|CSK_ENST00000439220.2_Silent_p.R283R|CSK_ENST00000309470.9_Silent_p.R283R	NM_004383.2	NP_004374.1	P41240	CSK_HUMAN	c-src tyrosine kinase	283	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			central_nervous_system(1)|lung(2)	3						CTAGGGGTCGGTCAGTGCTGG	0.632000													4	40					0	0	1	0	0
ZNF507	22847	broad.mit.edu	37	19	32844925	32844925	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:32844925G>C	ENST00000311921.3	+	2	1381	c.1189G>C	c.(1189-1191)Gtg>Ctg	p.V397L	ZNF507_ENST00000544431.1_Missense_Mutation_p.V397L|ZNF507_ENST00000587084.1_3'UTR|ZNF507_ENST00000355898.5_Missense_Mutation_p.V397L	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					GCATGTTAACGTGATAGTGGA	0.463000													11	60					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26784835	26784835	+	Silent	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:26784835C>G	ENST00000381340.3	-	22	3314	c.2898G>C	c.(2896-2898)gtG>gtC	p.V966V	RP11-666F17.1_ENST00000414098.2_RNA	NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	966					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					TGGTGTCCATCACAGTCACAT	0.498000													9	133					0	0	1	0	0
PPP2R2A	5520	broad.mit.edu	37	8	26212074	26212074	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:26212074G>T	ENST00000380737.3	+	4	600	c.271G>T	c.(271-273)Gaa>Taa	p.E91*	PPP2R2A_ENST00000315985.7_Nonsense_Mutation_p.E101*	NM_002717.3	NP_002708.1			protein phosphatase 2, regulatory subunit B, alpha											kidney(1)|large_intestine(2)|ovary(1)	4		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		GAAAAGTTTAGAAATAGAAGA	0.338000													5	43					1	1	1	1	0
KIAA1109	84162	broad.mit.edu	37	4	123249451	123249451	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:123249451G>A	ENST00000264501.4	+	66	11561	c.11188G>A	c.(11188-11190)Gag>Aag	p.E3730K	KIAA1109_ENST00000388738.3_Missense_Mutation_p.E3730K			Q2LD37	K1109_HUMAN	KIAA1109	3730					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TGAAGATTCCGAGAAGGATGA	0.418000													12	50					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960838	73960838	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:73960838C>A	ENST00000373468.1	-	3	4205	c.3554G>T	c.(3553-3555)gGg>gTg	p.G1185V	KIAA2022_ENST00000055682.5_Missense_Mutation_p.G1185V			Q5QGS0	K2022_HUMAN	KIAA2022	1185					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						GTTCATAGCCCCACTCTTGCT	0.413000													6	63					0.0215528	0.0219763	1	1	0
SLC30A3	7781	broad.mit.edu	37	2	27479696	27479696	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:27479696G>A	ENST00000233535.4	-	6	1195	c.843C>T	c.(841-843)acC>acT	p.T281T	SLC30A3_ENST00000447008.2_Silent_p.T276T	NM_003459.4	NP_003450.2	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter), member 3	281					regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|pancreas(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGTGGGAGCGGTGGATCCAA	0.582000													15	31					0	0	1	0	0
C1QTNF2	114898	broad.mit.edu	37	5	159776680	159776680	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:159776680C>T	ENST00000393975.3	-	3	491	c.488G>A	c.(487-489)gGg>gAg	p.G163E		NM_031908.4	NP_114114.2	Q9BXJ5	C1QT2_HUMAN	C1q and tumor necrosis factor related protein 2	118	C1q.					collagen				breast(2)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	13	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCCATGCTTCCCGGGGGTACC	0.687000													8	104					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123599866	123599866	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:123599866G>C	ENST00000340011.5	+	5	1730	c.1373G>C	c.(1372-1374)tGt>tCt	p.C458S	SPAM1_ENST00000223028.7_Missense_Mutation_p.C458S|SPAM1_ENST00000439500.1_Missense_Mutation_p.C458S|SPAM1_ENST00000402183.2_Missense_Mutation_p.C458S|SPAM1_ENST00000460182.1_Missense_Mutation_p.C458S	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	458					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	GTTGATGTGTGTATTGCTGAT	0.403000													49	52					0	0	1	0	0
RECQL	5965	broad.mit.edu	37	12	21643161	21643161	+	Nonsense_Mutation	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:21643161A>T	ENST00000444129.2	-	4	834	c.366T>A	c.(364-366)tgT>tgA	p.C122*	RECQL_ENST00000421138.2_Nonsense_Mutation_p.C122*	NM_002907.3|NM_032941.2	NP_002898.2|NP_116559.1	P46063	RECQ1_HUMAN	RecQ protein-like (DNA helicase Q1-like)	122	Helicase ATP-binding.				DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17						GTAACTGGTAACATAAGCTCT	0.338000								Other identified genes with known or suspected DNA repair function					27	83					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	16004574	16004574	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:16004574C>T	ENST00000268712.3	-	20	2937	c.2680G>A	c.(2680-2682)Gag>Aag	p.E894K	NCOR1_ENST00000395848.1_Missense_Mutation_p.E801K|NCOR1_ENST00000395851.1_Missense_Mutation_p.E910K	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	894					cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTCTGCCTCTCTGGCTCTCCA	0.562000													7	73					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168104094	168104094	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:168104094C>T	ENST00000409195.1	+	9	6281	c.6192C>T	c.(6190-6192)gtC>gtT	p.V2064V	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Silent_p.V1842V|XIRP2_ENST00000295237.9_Silent_p.V2064V|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1889					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAACGGGTGTCTGGACTGATA	0.353000													5	69					0	0	1	0	0
MFSD9	84804	broad.mit.edu	37	2	103335600	103335600	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:103335600C>T	ENST00000258436.5	-	6	747	c.704G>A	c.(703-705)cGa>cAa	p.R235Q		NM_032718.3	NP_116107.3	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing 9	235					transmembrane transport	integral to membrane|plasma membrane	transporter activity			breast(3)|large_intestine(7)|liver(1)|lung(6)|ovary(2)|skin(1)	20						ATGGGTCTTTCGCAATGGCAG	0.567000													11	142					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058229	152058229	+	Silent	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:152058229T>C	ENST00000368806.1	-	3	1993	c.1929A>G	c.(1927-1929)ccA>ccG	p.P643P		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	643							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CAGCTGCACCTGGGCCTTTGG	0.547000													12	132					0	0	1	0	0
ZNF587	84914	broad.mit.edu	37	19	58370928	58370928	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:58370928G>T	ENST00000339656.5	+	3	1330	c.1148G>T	c.(1147-1149)gGa>gTa	p.G383V	ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF587_ENST00000423137.1_Missense_Mutation_p.G382V|ZNF587_ENST00000419854.1_Missense_Mutation_p.G340V|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597342.1_Intron	NM_001204817.1|NM_032828.3	NP_001191746.1|NP_116217.1	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	383					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		TACAAGTGTGGAGAATGTGGG	0.458000													39	139					4.32679e-17	5.80636e-17	1	1	0
OPA1	4976	broad.mit.edu	37	3	193385011	193385011	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:193385011T>A	ENST00000361510.2	+	29	3159	c.2925T>A	c.(2923-2925)gaT>gaA	p.D975E	OPA1_ENST00000392438.3_Missense_Mutation_p.D920E|OPA1_ENST00000361715.2_Missense_Mutation_p.D939E|OPA1_ENST00000361908.3_Missense_Mutation_p.D957E|OPA1_ENST00000361150.2_Missense_Mutation_p.D921E|OPA1_ENST00000361828.2_Missense_Mutation_p.D938E	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	920					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		TTGCTGAAGATGGTGAGAAGA	0.383000													34	40					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885984	88885984	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:88885984G>T	ENST00000319675.3	-	1	312	c.216C>A	c.(214-216)gaC>gaA	p.D72E		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	72										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						GGTTAAATCGGTCGCTTGCCA	0.527000													28	80					2.48779e-11	3.19176e-11	1	1	0
PIAS3	10401	broad.mit.edu	37	1	145578314	145578314	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:145578314C>G	ENST00000393045.2	+	2	367	c.277C>G	c.(277-279)Cta>Gta	p.L93V	PIAS3_ENST00000369299.3_Missense_Mutation_p.L84V|PIAS3_ENST00000369298.1_Intron	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	93	Pro-rich.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CCCTGGTCCTCTAGCTCCCAT	0.657000													8	164					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	19864441	19864441	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:19864441A>C	ENST00000396085.1	+	3	771	c.410A>C	c.(409-411)aAt>aCt	p.N137T	NAV2_ENST00000534229.1_3'UTR|NAV2_ENST00000540292.1_Missense_Mutation_p.N68T|NAV2_ENST00000349880.4_Missense_Mutation_p.N137T|NAV2_ENST00000360655.4_Missense_Mutation_p.N73T|NAV2_ENST00000527559.2_Missense_Mutation_p.N66T|NAV2_ENST00000396087.3_Missense_Mutation_p.N137T	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	137	CH.					nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						GAAGACATCAATGGCTGTCCG	0.403000													8	65					0	0	1	0	0
ACTN3	89	broad.mit.edu	37	11	66323653	66323653	+	RNA	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:66323653C>T	ENST00000513398.1	+	0	853				ACTN3_ENST00000502692.1_RNA	NM_001104.2	NP_001095.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						AGAAGGCCATCATGACCTATG	0.607000													6	115					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107846989	107846989	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:107846989C>A	ENST00000285311.3	-	2	1045	c.340G>T	c.(340-342)Ggc>Tgc	p.G114C	DKK2_ENST00000513208.1_Missense_Mutation_p.G14C|DKK2_ENST00000510463.1_Missense_Mutation_p.G68C	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	114	DKK-type Cys-1.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CAGCACATGCCATCTCGGTGG	0.493000													36	86					2.19358e-23	3.00411e-23	1	1	0
DOCK5	80005	broad.mit.edu	37	8	25226163	25226163	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:25226163C>T	ENST00000276440.7	+	33	3404	c.3360C>T	c.(3358-3360)ctC>ctT	p.L1120L		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1120						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		AAGTAGAGCTCCGGAAAGCCA	0.448000													5	22					0	0	1	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17132110	17132110	+	Splice_Site	SNP	T	T	A	rs67139828		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:17132110T>A	ENST00000265970.7	-	21	3414		c.e21-2		PIK3C2A_ENST00000531428.1_Splice_Site|PIK3C2A_ENST00000540361.1_Splice_Site	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha						cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	TTCACCAACCTTGAAATCAAG	0.368000													10	49					0	0	1	0	0
STEAP1B	256227	broad.mit.edu	37	7	22532236	22532236	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:22532236G>C	ENST00000404369.4	-	4	1125	c.710C>G	c.(709-711)tCt>tGt	p.S237C	STEAP1B_ENST00000406890.2_Missense_Mutation_p.S218C	NM_001164460.1	NP_001157932.1	Q6NZ63	STEAL_HUMAN	STEAP family member 1B	218						integral to membrane	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity			endometrium(1)|kidney(1)|lung(2)	4						AGATGGAATAGATGTCACAGC	0.378000													5	69					0	0	1	0	0
LPIN3	64900	broad.mit.edu	37	20	39987102	39987102	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr20:39987102G>A	ENST00000373257.3	+	19	2422	c.2331G>A	c.(2329-2331)gtG>gtA	p.V777V	LPIN3_ENST00000491528.1_3'UTR	NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	777	C-LIP.				fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				ACCGGCAGGTGGGCCTGCCTG	0.607000													4	62					0	0	1	0	0
BMF	90427	broad.mit.edu	37	15	40398001	40398001	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr15:40398001A>T	ENST00000354670.4	-	3	521	c.287T>A	c.(286-288)tTt>tAt	p.F96Y	BMF_ENST00000558774.1_Missense_Mutation_p.F96Y|BMF_ENST00000559701.1_Missense_Mutation_p.F96Y|BMF_ENST00000220446.4_Missense_Mutation_p.F96Y|BMF_ENST00000431415.3_Missense_Mutation_p.F96Y|BMF_ENST00000397573.1_Missense_Mutation_p.F96Y|BMF_ENST00000561360.1_Missense_Mutation_p.F96Y|BMF_ENST00000561282.1_Missense_Mutation_p.F96Y	NM_001003940.1	NP_001003940.1	Q96LC9	BMF_HUMAN	Bcl2 modifying factor	96					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|mitochondrial outer membrane|myosin complex|plasma membrane	protein binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	6		all_cancers(109;4.18e-18)|all_epithelial(112;6.15e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0516)		CTCACCATAAAAGAGTCGCTG	0.577000													9	87					0	0	1	0	0
SUPT7L	9913	broad.mit.edu	37	2	27883966	27883966	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:27883966G>C	ENST00000337768.5	-	3	873	c.304C>G	c.(304-306)Ctt>Gtt	p.L102V	SUPT7L_ENST00000404798.2_Intron|SUPT7L_ENST00000464789.2_Missense_Mutation_p.L100V|SUPT7L_ENST00000406540.1_Missense_Mutation_p.L100V|SUPT7L_ENST00000405491.1_Missense_Mutation_p.L100V	NM_014860.1	NP_055675.1	O94864	ST65G_HUMAN	suppressor of Ty 7 (S. cerevisiae)-like	102					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)|skin(2)|urinary_tract(1)	16	Acute lymphoblastic leukemia(172;0.155)					CACGAGGGAAGAGGTTCACTC	0.522000													5	45					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56552345	56552345	+	Silent	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:56552345C>A	ENST00000390649.3	+	11	2844	c.2844C>A	c.(2842-2844)gtC>gtA	p.V948V		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	948						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CAGCCCTCGTCAGCAACCGGA	0.562000													6	80					0.0215528	0.0219763	1	1	0
COL11A1	1301	broad.mit.edu	37	1	103444964	103444964	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:103444964C>A	ENST00000358392.2	-	32	2937	c.2620G>T	c.(2620-2622)Ggt>Tgt	p.G874C	COL11A1_ENST00000512756.1_Missense_Mutation_p.G746C|COL11A1_ENST00000370096.3_Missense_Mutation_p.G862C|COL11A1_ENST00000353414.4_Missense_Mutation_p.G823C	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	862	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCATTGGCACCTGGAAACCCA	0.348000													9	28					3.86212e-05	4.2538e-05	1	1	0
PPP1R8	5511	broad.mit.edu	37	1	28169792	28169792	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:28169792G>T	ENST00000373931.4	+	5	957	c.162G>T	c.(160-162)agG>agT	p.R54S	PPP1R8_ENST00000236412.7_5'UTR|PPP1R8_ENST00000311772.5_Missense_Mutation_p.R196S	NM_138558.2	NP_612568.1	Q12972	PP1R8_HUMAN	protein phosphatase 1, regulatory subunit 8	196	FHA.|Interaction with CDC5L, SF3B1 and MELK.				mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|RNA splicing|transcription, DNA-dependent	cytoplasm|nuclear speck|spliceosomal complex	DNA binding|endonuclease activity|protein binding|protein serine/threonine phosphatase inhibitor activity|ribonuclease E activity|RNA binding			breast(2)|cervix(1)|endometrium(2)|lung(2)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|all_lung(284;0.000129)|Lung NSC(340;0.000259)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.76e-24)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00248)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)		AGAGGAAGAGGAAGAACTCAC	0.468000													6	109					2.7689e-08	3.29027e-08	1	1	0
OR4C6	219432	broad.mit.edu	37	11	55432682	55432682	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:55432682G>A	ENST00000314259.3	+	1	69	c.40G>A	c.(40-42)Ggt>Agt	p.G14S		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						CATTCTTCTGGGTCTCACAGA	0.378000													25	93					0	0	1	0	0
AGO3	192669	broad.mit.edu	37	1	36474327	36474327	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:36474327G>C	ENST00000373191.4	+	7	1179	c.830G>C	c.(829-831)aGa>aCa	p.R277T	AGO3_ENST00000246314.6_Missense_Mutation_p.R43T|RP4-665N4.8_ENST00000466576.2_RNA	NM_024852.3	NP_079128.2			argonaute RISC catalytic component 3																		GGAACAATGAGACGGAAATAC	0.403000													8	53					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142562064	142562064	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:142562064C>T	ENST00000392957.2	+	7	1293	c.506C>T	c.(505-507)tCc>tTc	p.S169F	EPHB6_ENST00000411471.2_Intron|EPHB6_ENST00000442129.1_Missense_Mutation_p.S169F	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	169	Poly-Ser.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					tcctcctcctcctcctcctcc	0.627000													13	139					0	0	1	0	0
STK24	8428	broad.mit.edu	37	13	99127078	99127078	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr13:99127078C>T	ENST00000397517.2	-	5	670	c.594G>A	c.(592-594)tcG>tcA	p.S198S	STK24_ENST00000539966.1_Silent_p.S179S|STK24_ENST00000376547.3_Silent_p.S210S	NM_001032296.2	NP_001027467.2	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24	210	Protein kinase.				cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CCCTCACCTTCGAGTCATAGG	0.587000													8	117					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881739	228881739	+	Silent	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:228881739G>C	ENST00000392056.3	-	7	3877	c.3831C>G	c.(3829-3831)gtC>gtG	p.V1277V	SPHKAP_ENST00000344657.5_Silent_p.V1277V	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1277						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ACGCGCTACTGACCGGCTGCA	0.517000													12	99					0	0	1	0	0
RAB5B	5869	broad.mit.edu	37	12	56383883	56383883	+	Splice_Site	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:56383883G>T	ENST00000360299.5	+	3	536		c.e3+1		RAB5B_ENST00000448789.2_Splice_Site|RAB5B_ENST00000553116.1_Splice_Site	NM_002868.3	NP_002859.1	P61020	RAB5B_HUMAN	RAB5B, member RAS oncogene family						protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|membrane fraction|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity			endometrium(1)|large_intestine(1)|liver(2)|lung(4)|upper_aerodigestive_tract(1)	9			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			TACTAATCAGGTAAGTGAGCT	0.512000													4	24					0.00024832	0.000269061	1	1	0
JAK2	3717	broad.mit.edu	37	9	5044488	5044488	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:5044488G>C	ENST00000381652.3	+	5	930	c.436G>C	c.(436-438)Gat>Cat	p.D146H	JAK2_ENST00000544510.1_5'UTR|JAK2_ENST00000539801.1_Missense_Mutation_p.D146H	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	146	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TCCTCTTCTTGATGACTTTGT	0.363000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				7	48					0	0	1	0	0
HBP1	26959	broad.mit.edu	37	7	106841863	106841863	+	Nonsense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:106841863C>G	ENST00000222574.4	+	11	1718	c.1532C>G	c.(1531-1533)tCa>tGa	p.S511*	HBP1_ENST00000485846.1_Nonsense_Mutation_p.S511*|HBP1_ENST00000468410.1_Nonsense_Mutation_p.S511*	NM_012257.3	NP_036389.2	O60381	HBP1_HUMAN	HMG-box transcription factor 1	511					cell cycle arrest|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	DNA binding			large_intestine(4)|lung(3)|prostate(1)|skin(2)	10						CCACAGGGCTCACAACAACAT	0.294000													7	34					0	0	1	0	0
TCEB3	6924	broad.mit.edu	37	1	24077443	24077443	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:24077443G>A	ENST00000418390.2	+	4	697	c.426G>A	c.(424-426)tgG>tgA	p.W142*		NM_003198.2	NP_003189.2	Q14241	ELOA1_HUMAN	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)	142					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		AAGAAACCTGGAAAGCCACGG	0.552000													7	55					0	0	1	0	0
KIAA1614	57710	broad.mit.edu	37	1	180897675	180897675	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:180897675C>A	ENST00000367588.4	+	4	1226	c.1171C>A	c.(1171-1173)Cat>Aat	p.H391N	KIAA1614_ENST00000367587.1_Missense_Mutation_p.H12N	NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	391										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						CCGTGCCAGCCATGACATCGT	0.667000													14	45					1.3612e-06	1.58524e-06	1	1	0
ZNF684	127396	broad.mit.edu	37	1	41012295	41012295	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:41012295G>A	ENST00000372699.3	+	5	551	c.300G>A	c.(298-300)ttG>ttA	p.L100L	ZNF684_ENST00000493756.1_3'UTR	NM_152373.3	NP_689586.3	Q5T5D7	ZN684_HUMAN	zinc finger protein 684	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(2)|lung(3)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.42e-18)			ACAATTTTTTGAAGTCAGTTT	0.333000													6	57					0	0	1	0	0
CXADRP3	440224	broad.mit.edu	37	18	14479179	14479179	+	RNA	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr18:14479179C>T	ENST00000581457.1	-	0	729					NR_024076.1																						TTGGCTTTTTCAATCATCTGC	0.527000													4	39					0	0	1	0	0
OR10A5	144124	broad.mit.edu	37	11	6867160	6867160	+	Silent	SNP	C	C	T	rs148877908	byFrequency	TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:6867160C>T	ENST00000299454.4	+	1	278	c.247C>T	c.(247-249)Ctg>Ttg	p.L83L	OR10A5_ENST00000379831.2_Silent_p.L87L			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	83					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCCCAAAATGCTGGGGACCCT	0.498000													47	91					0	0	1	0	0
TNIK	23043	broad.mit.edu	37	3	171177825	171177825	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:171177825G>A	ENST00000436636.2	-	1	372	c.28C>T	c.(28-30)Ctg>Ttg	p.L10L	TNIK_ENST00000488470.1_Silent_p.L10L|TNIK_ENST00000470834.1_Silent_p.L10L|TNIK_ENST00000460047.1_Silent_p.L10L|TNIK_ENST00000538048.1_Silent_p.L10L|TNIK_ENST00000475336.1_Silent_p.L10L|TNIK_ENST00000465393.1_Silent_p.L10L|TNIK_ENST00000369326.5_Silent_p.L10L|TNIK_ENST00000357327.5_Silent_p.L10L|TNIK_ENST00000341852.6_Silent_p.L10L|TNIK_ENST00000284483.8_Silent_p.L10L	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	10					actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			ATTTCATCCAGGCTTCGAGCC	0.537000													10	7					0	0	1	0	0
MAP3K12	7786	broad.mit.edu	37	12	53876099	53876099	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:53876099G>T	ENST00000267079.2	-	13	2419	c.2194C>A	c.(2194-2196)Ctg>Atg	p.L732M	MAP3K12_ENST00000547488.1_Missense_Mutation_p.L765M|MAP3K12_ENST00000547035.1_Missense_Mutation_p.L765M	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	732					histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						CTTGATGTCAGCTCTACTTCA	0.488000													9	173					0.000274275	0.000296496	1	1	0
LRRTM1	347730	broad.mit.edu	37	2	80530877	80530877	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:80530877C>A	ENST00000295057.3	-	2	724	c.68G>T	c.(67-69)tGt>tTt	p.C23F	CTNNA2_ENST00000466387.1_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.C23F|CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000540488.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	23						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						CCCCAGCAGACACAAGACCAC	0.637000										HNSCC(69;0.2)			5	56					0.00116845	0.00124015	1	1	0
KIAA1217	56243	broad.mit.edu	37	10	24833116	24833116	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:24833116G>A	ENST00000376451.2	+	14	4226	c.3966G>A	c.(3964-3966)agG>agA	p.R1322R	KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000376454.3_Silent_p.R1639R|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376462.1_Intron|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000307544.6_Intron			Q5T5P2	SKT_HUMAN	KIAA1217	1639					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						ACACAGTGAGGAGGCAAGAGC	0.478000													10	74					0	0	1	0	0
CTNNB1	1499	broad.mit.edu	37	3	41266113	41266113	+	Missense_Mutation	SNP	C	C	G	rs121913416		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:41266113C>G	ENST00000349496.5	+	3	390	c.110C>G	c.(109-111)tCt>tGt	p.S37C	CTNNB1_ENST00000396183.3_Missense_Mutation_p.S37C|CTNNB1_ENST00000453024.1_Missense_Mutation_p.S30C|CTNNB1_ENST00000405570.1_Missense_Mutation_p.S37C|CTNNB1_ENST00000396185.3_Missense_Mutation_p.S37C	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	37			S -> A (in MDB and hepatocellular carcinoma; enhances transactivation of target genes).|S -> C (in PTR, hepatoblastoma and ovarian cancer).|S -> F (in PTR).|S -> Y (in hepatocellular carcinoma).|SG -> W (in hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.S37F(172)|p.S37C(141)|p.A5_A80del(53)|p.S37Y(31)|p.A5_Q143del(7)|p.A5_A80>D(7)|p.Q28_H134del(5)|p.?(4)|p.V22_G38del(3)|p.W25_I140del(3)|p.T3_A126del(2)|p.A5fs*7(2)|p.D32_S47del(2)|p.M5_N141>D(2)|p.L10_N141del(2)|p.A5_Y142>D(2)|p.A5_Q143>E(1)|p.S37_G48>C(1)|p.A13_R151del(1)|p.H36_E53>L(1)|p.M14_S45del(1)|p.A20_N141del(1)|p.M1_A87del(1)|p.D11_Y142>H(1)|p.I35_K170del(1)|p.H24_G38del(1)|p.I35_T41del(1)|p.I35_G38del(1)|p.Y30_A97del(1)|p.V22_T102del(1)|p.A20_A80del(1)|p.V22_S71>A(1)|p.Q28_A43del(1)|p.A5_T59del(1)|p.M1_V173del(1)|p.E15_I140>V(1)|p.S23_A39del(1)|p.H24_M131del(1)|p.A21_A80del(1)|p.D32fs*9(1)|p.A5_T40del(1)|p.A5_E54del(1)|p.S33_S37del(1)|p.M8_A80del(1)|p.P16_K133del(1)|p.V22_Y64del(1)|p.Q28_Q61del(1)|p.A20_S111del(1)|p.Y30_T40del(1)|p.GIHS34?(1)|p.S37_G38>W(1)|p.Y30_A80del(1)	CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	GGAATCCATTCTGGTGCCACT	0.498000	S37C(JHUEM2_ENDOMETRIUM)|S37C(SNU398_LIVER)|S37F(HUTU80_SMALL_INTESTINE)	15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				4	41					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101845298	101845298	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:101845298G>A	ENST00000360264.3	+	18	2774	c.2754G>A	c.(2752-2754)caG>caA	p.Q918Q	CUX1_ENST00000550008.2_Silent_p.Q851Q|CUX1_ENST00000549414.2_Silent_p.Q885Q|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000546411.2_Silent_p.Q805Q|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000437600.4_Intron|CUX1_ENST00000556210.1_Silent_p.Q749Q|CUX1_ENST00000292535.7_Silent_p.Q907Q|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000292538.4_Intron	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	907					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						AGACACCACAGAACAGCCCCC	0.652000													7	119					0	0	1	0	0
ABCF1	23	broad.mit.edu	37	6	30552239	30552239	+	Silent	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:30552239C>A	ENST00000326195.8	+	14	1399	c.1287C>A	c.(1285-1287)gcC>gcA	p.A429A	ABCF1_ENST00000396515.4_Intron|ABCF1_ENST00000376545.3_Silent_p.A391A	NM_001025091.1	NP_001020262.1	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 1	429	ABC transporter 1.				inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						CTGCAGAGGCCAAAGCACGGC	0.622000													5	79					0.000602214	0.000645032	1	1	0
DNM1L	10059	broad.mit.edu	37	12	32858780	32858780	+	Nonsense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:32858780C>G	ENST00000381000.4	+	3	313	c.272C>G	c.(271-273)tCa>tGa	p.S91*	DNM1L_ENST00000547312.1_Intron|DNM1L_ENST00000553257.1_Nonsense_Mutation_p.S91*|DNM1L_ENST00000266481.6_Intron|DNM1L_ENST00000452533.2_Intron|DNM1L_ENST00000414834.2_Missense_Mutation_p.Q23E|DNM1L_ENST00000358214.5_Nonsense_Mutation_p.S91*|DNM1L_ENST00000548671.1_Intron|DNM1L_ENST00000549701.1_Intron	NM_001278463.1|NM_001278465.1	NP_001265392.1|NP_001265394.1	O00429	DNM1L_HUMAN	dynamin 1-like	83	GTPase domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	23	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGGAAAAACTCAAGACACCTT	0.338000													12	153					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62289005	62289005	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:62289005C>A	ENST00000378024.4	-	5	13158	c.12884G>T	c.(12883-12885)gGc>gTc	p.G4295V	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4295					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CACTTTGGGGCCCTTGATGTC	0.507000													89	194					4.493e-44	6.24473e-44	1	1	0
ROM1	6094	broad.mit.edu	37	11	62381902	62381902	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:62381902G>A	ENST00000278833.3	+	2	1304	c.763G>A	c.(763-765)Gag>Aag	p.E255K	ROM1_ENST00000534093.1_Missense_Mutation_p.M45I	NM_000327.3	NP_000318.1	Q03395	ROM1_HUMAN	retinal outer segment membrane protein 1	255					cell adhesion|visual perception	integral to plasma membrane				central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	8						AGGGTGCCATGAGGTGCTGCT	0.592000													5	68					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22248881	22248881	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:22248881A>C	ENST00000324559.8	+	7	714	c.397A>C	c.(397-399)Atc>Ctc	p.I133L		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	133						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TTTTGTCAAGATCCATGCCCC	0.398000													6	134					0	0	1	0	0
ZEB2	9839	broad.mit.edu	37	2	145157316	145157316	+	Missense_Mutation	SNP	C	C	A	rs143854197	byFrequency	TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:145157316C>A	ENST00000558170.2	-	8	2622	c.1438G>T	c.(1438-1440)Gct>Tct	p.A480S	ZEB2_ENST00000409487.3_Missense_Mutation_p.A480S|ZEB2_ENST00000539609.3_Missense_Mutation_p.A456S|ZEB2_ENST00000303660.4_Missense_Mutation_p.A480S	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	480	SMAD-MH2 binding domain (By similarity).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		ATTTCTTCAGCCTTGCAGTCC	0.403000													9	70					2.17888e-05	2.45782e-05	1	1	0
ABHD17B	51104	broad.mit.edu	37	9	74485025	74485025	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:74485025C>A	ENST00000333421.6	-	3	732	c.621G>T	c.(619-621)aaG>aaT	p.K207N	ABHD17B_ENST00000377041.2_Missense_Mutation_p.K207N	NM_001025780.1	NP_001020951.1			abhydrolase domain containing 17B																		AACAGTAGGTCTTCTTGGTAT	0.383000													19	67					1.56452e-12	2.02954e-12	1	1	0
PSG5	5673	broad.mit.edu	37	19	43683276	43683276	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:43683276T>A	ENST00000599812.1	-	3	559	c.464A>T	c.(463-465)aAc>aTc	p.N155I	PSG5_ENST00000404580.1_Intron|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000407356.1_Intron|PSG5_ENST00000342951.6_Intron|PSG5_ENST00000366175.3_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	155	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				GGGGTTTAAGTTGCTACTGGA	0.512000													11	191					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118516175	118516175	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:118516175G>T	ENST00000336338.5	-	44	6079	c.6014C>A	c.(6013-6015)tCt>tAt	p.S2005Y	SPAG17_ENST00000492438.1_5'UTR	NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	2005						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GGGCTCATAAGATTCTGCTTC	0.383000													30	53					2.08457e-15	2.75777e-15	1	1	0
TENM1	10178	broad.mit.edu	37	X	123631040	123631040	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:123631040T>A	ENST00000422452.2	-	20	3584	c.3521A>T	c.(3520-3522)aAt>aTt	p.N1174I	TENM1_ENST00000371130.3_Missense_Mutation_p.N1174I	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TTGGTGTCCATTACCCATTAT	0.463000													7	10					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212248726	212248726	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:212248726G>A	ENST00000342788.4	-	28	3851	c.3541C>T	c.(3541-3543)Caa>Taa	p.Q1181*	ERBB4_ENST00000436443.1_Nonsense_Mutation_p.Q1165*|ERBB4_ENST00000402597.1_Nonsense_Mutation_p.Q1171*	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	1181					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TCCAATGCTTGAAGGTCTCCA	0.428000										TSP Lung(8;0.080)			7	104					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103444963	103444963	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:103444963C>A	ENST00000358392.2	-	32	2938	c.2621G>T	c.(2620-2622)gGt>gTt	p.G874V	COL11A1_ENST00000512756.1_Missense_Mutation_p.G746V|COL11A1_ENST00000370096.3_Missense_Mutation_p.G862V|COL11A1_ENST00000353414.4_Missense_Mutation_p.G823V	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	862	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCCATTGGCACCTGGAAACCC	0.348000													9	28					3.86212e-05	4.2538e-05	1	1	0
ELTD1	64123	broad.mit.edu	37	1	79387416	79387416	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:79387416A>T	ENST00000370742.3	-	9	1202	c.1139T>A	c.(1138-1140)aTg>aAg	p.M380K		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	380	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		GCTGCCATTCATGGTATCAGG	0.403000													7	86					0	0	1	0	0
PLEKHB2	55041	broad.mit.edu	37	2	131883344	131883344	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:131883344G>T	ENST00000403716.1	+	3	616	c.56G>T	c.(55-57)tGg>tTg	p.W19L	PLEKHB2_ENST00000538982.1_5'UTR|PLEKHB2_ENST00000409158.1_Missense_Mutation_p.W19L|PLEKHB2_ENST00000303908.3_Missense_Mutation_p.W19L|PLEKHB2_ENST00000409279.1_Missense_Mutation_p.W19L|PLEKHB2_ENST00000438882.2_Missense_Mutation_p.W19L|PLEKHB2_ENST00000439822.2_Missense_Mutation_p.W19L|PLEKHB2_ENST00000404460.1_Missense_Mutation_p.W19L|PLEKHB2_ENST00000409612.1_Missense_Mutation_p.W19L|PLEKHB2_ENST00000234115.6_Missense_Mutation_p.W19L	NM_001100623.1|NM_001267062.1|NM_001267063.1|NM_001267064.1|NM_001267065.1|NM_001267066.1|NM_017958.2	NP_001094093.1|NP_001253991.1|NP_001253992.1|NP_001253993.1|NP_001253994.1|NP_001253995.1|NP_060428.2	Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	19	PH.					membrane	protein binding			large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		TTGAAGCGCTGGAAGAAGAAC	0.413000													5	49					0.000602214	0.000645032	1	1	0
RUVBL1	8607	broad.mit.edu	37	3	127816235	127816235	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:127816235G>A	ENST00000464873.1	-	8	1494	c.744C>T	c.(742-744)gaC>gaT	p.D248D	RUVBL1_ENST00000322623.5_Silent_p.D308D|RUVBL1_ENST00000417360.1_Silent_p.D308D			Q9Y265	RUVB1_HUMAN	RuvB-like AAA ATPase 1	308					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26				GBM - Glioblastoma multiforme(114;0.181)		AGCACTCAATGTCCAGCATGT	0.532000													45	31					0	0	1	0	0
PGA5	5222	broad.mit.edu	37	11	61015906	61015906	+	Silent	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:61015906C>A	ENST00000312403.5	+	6	857	c.672C>A	c.(670-672)ggC>ggA	p.G224G	PGA5_ENST00000451616.2_Silent_p.G70G|CTD-2331C18.5_ENST00000537594.1_RNA|PGA4_ENST00000422676.2_Silent_p.G224G	NM_014224.2	NP_055039.1	P00790	PEPA_HUMAN	pepsinogen 5, group I (pepsinogen A)	224					digestion|proteolysis	extracellular region	aspartic-type endopeptidase activity			large_intestine(1)|skin(1)	2						ACAAGAGTGGCAGCGTGGTGA	0.507000													73	295					1.45872e-26	2.0095e-26	1	1	0
HECW1	23072	broad.mit.edu	37	7	43540317	43540317	+	Silent	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:43540317C>A	ENST00000395891.1	+	20	4062	c.3457C>A	c.(3457-3459)Cgg>Agg	p.R1153R	HECW1_ENST00000453890.1_Silent_p.R1119R	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1153					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CCATTACATTCGGACTGAGGG	0.423000													43	67					5.7616e-29	7.98418e-29	1	1	0
FLG	2312	broad.mit.edu	37	1	152281218	152281218	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:152281218C>A	ENST00000368799.1	-	3	6179	c.6144G>T	c.(6142-6144)gaG>gaT	p.E2048D	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2048	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGAATGTCCCTCACTGTCAC	0.567000									Ichthyosis				213	508					5.21952e-89	7.29795e-89	1	1	0
GPR174	84636	broad.mit.edu	37	X	78426721	78426721	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:78426721C>A	ENST00000276077.1	+	1	253	c.217C>A	c.(217-219)Cca>Aca	p.P73T		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	73						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						TCTTTCCTTGCCACTGAGGAT	0.403000										HNSCC(63;0.18)			13	7					7.03913e-09	8.47235e-09	1	1	0
WDR33	55339	broad.mit.edu	37	2	128522374	128522374	+	Silent	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:128522374T>A	ENST00000409658.3	-	6	836	c.654A>T	c.(652-654)gtA>gtT	p.V218V	WDR33_ENST00000393006.1_Intron|WDR33_ENST00000322313.4_Intron	NM_001006622.2	NP_001006623.1	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	0					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CAATAGGGACTACAGAAAATG	0.413000													31	57					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48711922	48711922	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:48711922G>C	ENST00000314191.2	-	73	10199	c.10143C>G	c.(10141-10143)ttC>ttG	p.F3381L	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Missense_Mutation_p.F3381L	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	3382	FAT.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AGAGGTGCTGGAATGCTCTCT	0.557000								Non-homologous end-joining					5	98					0	0	1	0	0
SLC25A2	83884	broad.mit.edu	37	5	140683155	140683155	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:140683155C>A	ENST00000239451.4	-	1	457	c.278G>T	c.(277-279)aGg>aTg	p.R93M		NM_031947.2	NP_114153.1	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2	93					mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			breast(3)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	19		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	AGCCACTTTCCTGACAAACTG	0.602000													20	99					3.62473e-10	4.50199e-10	1	1	0
PLEKHH2	130271	broad.mit.edu	37	2	43958690	43958690	+	Silent	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:43958690G>C	ENST00000282406.4	+	19	3002	c.2892G>C	c.(2890-2892)ctG>ctC	p.L964L		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	964	MyTH4.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTTCCCCTCTGACAACTCTAC	0.328000													30	38					0	0	1	0	0
SYF2	25949	broad.mit.edu	37	1	25549807	25549807	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:25549807T>C	ENST00000236273.4	-	7	707	c.682A>G	c.(682-684)Aaa>Gaa	p.K228E	SYF2_ENST00000354361.3_Missense_Mutation_p.K186E	NM_015484.4	NP_056299.1	O95926	SYF2_HUMAN	SYF2 pre-mRNA-splicing factor	228						catalytic step 2 spliceosome				kidney(1)|large_intestine(1)|lung(4)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)		GCTGTGTATTTCCCATAGAAT	0.358000													27	76					0	0	1	0	0
P4HB	5034	broad.mit.edu	37	17	79803471	79803471	+	Missense_Mutation	SNP	G	G	A	rs3210169		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:79803471G>A	ENST00000331483.4	-	9	1547	c.1325C>T	c.(1324-1326)aCa>aTa	p.T442I	P4HB_ENST00000576390.1_Intron|P4HB_ENST00000439918.2_Missense_Mutation_p.T398I	NM_000918.3	NP_000909.2	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta polypeptide	442	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			NS(1)|breast(1)|large_intestine(2)|lung(17)|urinary_tract(1)	22	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			GAACTTGAGTGTGGGGAAGCT	0.612000													9	32					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207171696	207171696	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:207171696T>C	ENST00000374423.3	+	5	2830	c.2444T>C	c.(2443-2445)gTt>gCt	p.V815A		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	815							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GAAGAAACTGTTGATCTGGAA	0.343000													4	54					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73521483	73521483	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:73521483G>A	ENST00000418310.1	+	8	1217	c.1115G>A	c.(1114-1116)gGg>gAg	p.G372E	LIMK1_ENST00000538333.3_Missense_Mutation_p.G308E|LIMK1_ENST00000336180.2_Missense_Mutation_p.G342E			P53667	LIMK1_HUMAN	LIM domain kinase 1	342	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding	p.G342E(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				CTCATCCACGGGGAGGTGCTG	0.677000													6	24					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235973570	235973570	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:235973570C>G	ENST00000389794.3	-	5	722	c.548G>C	c.(547-549)aGa>aCa	p.R183T	LYST_ENST00000389793.2_Missense_Mutation_p.R183T|LYST_ENST00000536965.1_Missense_Mutation_p.R183T			Q99698	LYST_HUMAN	lysosomal trafficking regulator	183					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ATGGGGCCTTCTATGCTTATT	0.433000													8	168					0	0	1	0	0
ROM1	6094	broad.mit.edu	37	11	62381857	62381857	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:62381857G>C	ENST00000278833.3	+	2	1259	c.718G>C	c.(718-720)Gat>Cat	p.D240H	ROM1_ENST00000534093.1_Silent_p.S30S	NM_000327.3	NP_000318.1	Q03395	ROM1_HUMAN	retinal outer segment membrane protein 1	240					cell adhesion|visual perception	integral to plasma membrane				central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	8						CCCCCTGTTCGATCCCCGACA	0.602000													7	83					0	0	1	0	0
RNMTL1	55178	broad.mit.edu	37	17	686352	686352	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:686352C>A	ENST00000304478.4	+	2	450	c.344C>A	c.(343-345)cCa>cAa	p.P115Q		NM_018146.2	NP_060616.1	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	115					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		AAGTCCAGGCCATTTCGGGAA	0.423000													6	67					2.7689e-08	3.29027e-08	1	1	0
LYPD1	116372	broad.mit.edu	37	2	133426000	133426000	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:133426000G>C	ENST00000397463.2	-	2	435	c.163C>G	c.(163-165)Cag>Gag	p.Q55E	LYPD1_ENST00000345008.6_Missense_Mutation_p.Q3E	NM_144586.5	NP_653187.3	Q8N2G4	LYPD1_HUMAN	LY6/PLAUR domain containing 1	55	UPAR/Ly6.					anchored to membrane|plasma membrane				lung(2)	2						ACTTCTTTCTGACACATGTCT	0.537000													6	83					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55098804	55098804	+	Silent	SNP	C	C	A	rs35764505		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:55098804C>A	ENST00000251377.3	+	9	1576	c.1443C>A	c.(1441-1443)gcC>gcA	p.A481A	LILRA2_ENST00000251376.3_Silent_p.A464A|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000391737.1_Silent_p.A452A|LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000391738.3_Silent_p.A481A|LILRB1_ENST00000396321.2_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		AAGATGCAGCCGGGAGGTGAA	0.567000													9	36					2.17888e-05	2.45782e-05	1	1	0
NT5C1A	84618	broad.mit.edu	37	1	40131834	40131834	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:40131834G>A	ENST00000235628.1	-	2	209	c.210C>T	c.(208-210)atC>atT	p.I70I		NM_032526.1	NP_115915.1	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	70					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			breast(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)	15	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GCTCCGTGTAGATCTGCTGCT	0.592000													4	59					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248367127	248367127	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:248367127G>T	ENST00000456743.1	+	1	796	c.758G>T	c.(757-759)gGa>gTa	p.G253V		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATGTACTATGGAGCAGCTTTG	0.488000													87	189					2.93434e-44	4.09055e-44	1	1	0
ZBTB41	360023	broad.mit.edu	37	1	197147608	197147608	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:197147608C>T	ENST00000367405.4	-	6	1779	c.1711G>A	c.(1711-1713)Gga>Aga	p.G571R	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	571					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						GGCTTTTCTCCACTGTGGATT	0.308000													10	38					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109438052	109438052	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr13:109438052G>C	ENST00000356711.2	+	5	637	c.511G>C	c.(511-513)Gaa>Caa	p.E171Q	MYO16_ENST00000251041.5_Missense_Mutation_p.E171Q|MYO16_ENST00000467639.1_3'UTR|MYO16_ENST00000357550.2_Missense_Mutation_p.E171Q	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	171					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AGAAGGGACAGAATCCAGCTC	0.348000													8	36					0	0	1	0	0
GOLGA3	2802	broad.mit.edu	37	12	133358997	133358997	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:133358997T>C	ENST00000204726.3	-	17	3908	c.3350A>G	c.(3349-3351)gAg>gGg	p.E1117G	GOLGA3_ENST00000450791.2_Missense_Mutation_p.E1117G|GOLGA3_ENST00000456883.2_Missense_Mutation_p.E1117G	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	1117					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		CTTCCCTTTCTCGTGCTCTAA	0.493000													8	127					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577574	7577574	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:7577574T>C	ENST00000420246.2	-	7	839	c.707A>G	c.(706-708)tAc>tGc	p.Y236C	TP53_ENST00000269305.4_Missense_Mutation_p.Y236C|TP53_ENST00000445888.2_Missense_Mutation_p.Y236C|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000413465.2_Missense_Mutation_p.Y236C|TP53_ENST00000359597.4_Missense_Mutation_p.Y236C|TP53_ENST00000455263.2_Missense_Mutation_p.Y236C	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	236	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y236C(61)|p.0?(8)|p.?(5)|p.Y143C(5)|p.Y236del(4)|p.Y236S(3)|p.Y236_M237delYM(1)|p.I232_Y236delIHYNY(1)|p.H233fs*6(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.Y236fs*4(1)|p.H233_C242del10(1)|p.N235_Y236delNY(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTACACATGTAGTTGTAGTG	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	25					0	0	1	0	0
ZNF131	7690	broad.mit.edu	37	5	43161568	43161568	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:43161568G>T	ENST00000509634.1	+	4	1045	c.589G>T	c.(589-591)Gta>Tta	p.V197L	ZNF131_ENST00000509156.1_Missense_Mutation_p.V197L|ZNF131_ENST00000505606.2_Missense_Mutation_p.V197L|ZNF131_ENST00000399534.1_Missense_Mutation_p.V197L|ZNF131_ENST00000306938.4_Missense_Mutation_p.V197L|ZNF131_ENST00000509931.1_Intron			P52739	ZN131_HUMAN	zinc finger protein 131	197						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	17						CAAGCAGTCCGTAAAGTACAT	0.463000													10	52					3.07112e-06	3.55003e-06	1	1	0
MUC17	140453	broad.mit.edu	37	7	100679320	100679320	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:100679320C>T	ENST00000306151.4	+	3	4687	c.4623C>T	c.(4621-4623)acC>acT	p.T1541T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1541	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CTGCTGTCACCAGCACACCTG	0.483000													28	355					0	0	1	0	0
XRCC1	7515	broad.mit.edu	37	19	44079131	44079131	+	Silent	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:44079131G>C	ENST00000262887.5	-	2	622	c.75C>G	c.(73-75)ctC>ctG	p.L25L	L34079.4_ENST00000600242.1_RNA|XRCC1_ENST00000543982.1_Intron|L34079.2_ENST00000594374.1_Intron			P18887	XRCC1_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 1	25					base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Prostate(69;0.0153)				TGTCTGCCTTGAGAAGATTTT	0.532000								Other BER factors					5	38					0	0	1	0	0
ZER1	10444	broad.mit.edu	37	9	131502280	131502280	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:131502280C>T	ENST00000291900.2	-	13	2378	c.1972G>A	c.(1972-1974)Gag>Aag	p.E658K		NM_006336.2	NP_006327.2	Q7Z7L7	ZER1_HUMAN	zyg-11 related, cell cycle regulator	658					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	15						TCCTCCACCTCCTCACGCTGG	0.612000													5	59					0	0	1	0	0
CASP1	834	broad.mit.edu	37	11	104905202	104905202	+	Splice_Site	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:104905202C>A	ENST00000533400.1	-	2	43		c.e2-1		CASP1_ENST00000593315.1_Splice_Site|CASP1_ENST00000531166.1_Splice_Site|CASP1_ENST00000415981.2_Splice_Site|CASP1_ENST00000598974.1_Splice_Site|CASP1_ENST00000353247.5_Splice_Site|CASP1_ENST00000528974.1_Intron|CASP1_ENST00000436863.3_Splice_Site|CASP1_ENST00000534497.1_Splice_Site|CASP1_ENST00000446369.1_Splice_Site|CASP1_ENST00000594519.1_Splice_Site|CASP1_ENST00000527979.1_5'UTR|CASP1_ENST00000393136.4_Splice_Site|CASP1_ENST00000525825.1_Splice_Site|CASP1_ENST00000526568.1_Splice_Site	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase						cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	AGGACCTTGTCTGTTTAGAGC	0.393000													19	272					1.64113e-05	1.86022e-05	1	1	0
MYO3A	53904	broad.mit.edu	37	10	26465772	26465772	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:26465772C>T	ENST00000265944.5	+	31	4602	c.4436C>T	c.(4435-4437)tCa>tTa	p.S1479L	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1479					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						CAGTGCCTCTCAGGTAAAAAT	0.393000													5	55					0	0	1	0	0
WDR25	79446	broad.mit.edu	37	14	100996353	100996353	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:100996353G>T	ENST00000335290.6	+	7	1836	c.1610G>T	c.(1609-1611)gGa>gTa	p.G537V	WDR25_ENST00000557502.1_3'UTR|WDR25_ENST00000554998.1_Missense_Mutation_p.G537V|WDR25_ENST00000542471.2_Missense_Mutation_p.G280V|WDR25_ENST00000402312.3_Missense_Mutation_p.G537V	NM_024515.4	NP_078791.3	Q64LD2	WDR25_HUMAN	WD repeat domain 25	537										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|skin(1)	20		Melanoma(154;0.212)				TGCTCCTGGGGAGGGGACATG	0.612000													5	51					0.00116845	0.00124015	1	1	0
SOS2	6655	broad.mit.edu	37	14	50626701	50626701	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:50626701C>G	ENST00000216373.5	-	10	1574	c.1300G>C	c.(1300-1302)Gat>Cat	p.D434H	SOS2_ENST00000543680.1_Missense_Mutation_p.D401H|SOS2_ENST00000555794.1_5'UTR	NM_006939.2	NP_008870.2	Q07890	SOS2_HUMAN	son of sevenless homolog 2 (Drosophila)	434					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(16)|ovary(2)|skin(1)	39	all_epithelial(31;0.000822)|Breast(41;0.0065)					TGTCCAATATCTTTGCCTTCC	0.363000													15	187					0	0	1	0	0
KLHL32	114792	broad.mit.edu	37	6	97489402	97489402	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:97489402C>T	ENST00000369261.4	+	4	602	c.239C>T	c.(238-240)gCt>gTt	p.A80V	KLHL32_ENST00000539200.1_Intron|KLHL32_ENST00000536676.1_Intron|KLHL32_ENST00000544166.1_5'UTR	NM_052904.3	NP_443136.2	Q96NJ5	KLH32_HUMAN	kelch-like family member 32	80	BTB.									breast(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(13)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		GAAAGTGGAGCTGATGAGGTT	0.443000													12	46					0	0	1	0	0
SEMA3E	9723	broad.mit.edu	37	7	82997168	82997168	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:82997168C>T	ENST00000307792.3	-	17	2529	c.2062G>A	c.(2062-2064)Gag>Aag	p.E688K	SEMA3E_ENST00000427262.1_Missense_Mutation_p.E628K	NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	688					axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				TGCCTGTCCTCCTCATCGTCC	0.483000													6	93					0	0	1	0	0
MALT1	10892	broad.mit.edu	37	18	56414745	56414745	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr18:56414745G>C	ENST00000348428.3	+	17	2404	c.2146G>C	c.(2146-2148)Gac>Cac	p.D716H	MALT1_ENST00000345724.3_Missense_Mutation_p.D705H|RP11-126O1.4_ENST00000588835.1_RNA	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	716					activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						TGCTAAATTAGACATGCATCG	0.438000			T	BIRC3	MALT								14	107					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29642559	29642559	+	Silent	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:29642559G>T	ENST00000318184.5	-	6	695	c.696C>A	c.(694-696)gcC>gcA	p.A232A		NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	232	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GTACCTGGCAGGCGTCCATTC	0.493000													3	10					0.150653	0.151301	1	1	0
GPR160	26996	broad.mit.edu	37	3	169801827	169801827	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:169801827G>T	ENST00000355897.5	+	4	675	c.67G>T	c.(67-69)Gat>Tat	p.D23Y		NM_014373.2	NP_055188.1	Q9UJ42	GP160_HUMAN	G protein-coupled receptor 160	23						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|kidney(1)|large_intestine(3)|lung(2)	8	all_cancers(22;3.26e-22)|all_epithelial(15;5.71e-27)|all_lung(20;8.41e-17)|Lung NSC(18;3.49e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			CCAGCCCCTAGATGTTAACTA	0.338000													6	99					2.0095e-06	2.33442e-06	1	1	0
CNRIP1	25927	broad.mit.edu	37	2	68544395	68544395	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:68544395G>A	ENST00000263655.3	-	2	829	c.224C>T	c.(223-225)tCt>tTt	p.S75F	CNRIP1_ENST00000481714.1_5'UTR|CNRIP1_ENST00000409862.1_Missense_Mutation_p.S75F|CNRIP1_ENST00000409559.3_Missense_Mutation_p.S75F	NM_015463.2	NP_056278.1	Q96F85	CNRP1_HUMAN	cannabinoid receptor interacting protein 1	75							protein binding			kidney(1)|large_intestine(5)|liver(1)|lung(1)|skin(1)	9						AGGCTCTTTAGACTTCAGTTC	0.488000													5	84					0	0	1	0	0
SERINC1	57515	broad.mit.edu	37	6	122777625	122777625	+	Splice_Site	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:122777625C>G	ENST00000368454.1	-	5	701		c.e5+1		SERINC1_ENST00000339697.3_Splice_Site			Q9NRX5	SERC1_HUMAN	serine incorporator 1						phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	L-serine transmembrane transporter activity|protein binding			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(1)	13				GBM - Glioblastoma multiforme(226;0.126)		TAAAAACTTACCCATTGTGCA	0.348000													6	45					0	0	1	0	0
TRIM51HP	440041	broad.mit.edu	37	11	55065006	55065006	+	RNA	SNP	A	A	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:55065006A>C	ENST00000526016.1	-	0	419					NR_038174.2																						TGAGATTTTCACAAGCTTTTT	0.393000													10	41					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72152331	72152331	+	Silent	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:72152331G>C	ENST00000555818.1	+	10	3705	c.3357G>C	c.(3355-3357)ggG>ggC	p.G1119G	SIPA1L1_ENST00000381232.3_Silent_p.G1119G|SIPA1L1_ENST00000537413.1_Silent_p.G594G|SIPA1L1_ENST00000358550.2_Silent_p.G1119G	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1119					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CCAGTGACGGGCGCCCACTAG	0.532000													4	40					0	0	1	0	0
SLC19A2	10560	broad.mit.edu	37	1	169435115	169435115	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:169435115T>A	ENST00000236137.5	-	6	1702	c.1466A>T	c.(1465-1467)cAa>cTa	p.Q489L	SLC19A2_ENST00000367804.3_Missense_Mutation_p.Q288L|SLC19A2_ENST00000367802.3_Missense_Mutation_p.Q451L	NM_006996.2	NP_008927.1	O60779	S19A2_HUMAN	solute carrier family 19 (thiamine transporter), member 2	489					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	11	all_hematologic(923;0.208)					AGAACTTGATTGTGGATCTTC	0.403000													20	79					0	0	1	0	0
PTGER3	5733	broad.mit.edu	37	1	71477983	71477983	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:71477983G>C	ENST00000370924.4	-	2	1312	c.1082C>G	c.(1081-1083)gCa>gGa	p.A361G	PTGER3_ENST00000306666.5_Intron|PTGER3_ENST00000356595.4_Intron|PTGER3_ENST00000370931.3_Intron|PTGER3_ENST00000414819.1_Intron|PTGER3_ENST00000354608.5_Intron|PTGER3_ENST00000370932.2_Intron|PTGER3_ENST00000460330.1_Intron|PTGER3_ENST00000351052.5_Missense_Mutation_p.A361G	NM_198715.2	NP_942008.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	0					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	GACAGCATTTGCTACCTGGCA	0.413000													7	58					0	0	1	0	0
FEM1C	56929	broad.mit.edu	37	5	114860108	114860108	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:114860108G>A	ENST00000274457.3	-	3	2312	c.1751C>T	c.(1750-1752)aCc>aTc	p.T584I		NM_020177.2	NP_064562.1	Q96JP0	FEM1C_HUMAN	fem-1 homolog c (C. elegans)	584						cytoplasm				breast(5)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	18		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)		CTGCAATGTGGTATGATTTAT	0.378000													5	68					0	0	1	0	0
CDC6	990	broad.mit.edu	37	17	38450672	38450672	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:38450672G>C	ENST00000209728.4	+	7	1471	c.1000G>C	c.(1000-1002)Gaa>Caa	p.E334Q		NM_001254.3	NP_001245.1	Q99741	CDC6_HUMAN	cell division cycle 6	334					cell division|DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|mitosis|negative regulation of cell proliferation|negative regulation of DNA replication|positive regulation of cell cycle cytokinesis|positive regulation of chromosome segregation|regulation of cyclin-dependent protein kinase activity|regulation of mitotic anaphase|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm|spindle midzone|spindle pole	ATP binding|kinase binding|nucleoside-triphosphatase activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	21						TCAAGCTAGAGAAAAATGTAA	0.388000													8	75					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106810990	106810990	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:106810990C>T	ENST00000407775.2	+	7	1028	c.778C>T	c.(778-780)Cgg>Tgg	p.R260W	RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.R128W|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.R128W|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000378472.4_5'UTR|RP11-152P17.2_ENST00000509144.2_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	260					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CATCTGGTATCGGAGTGAGCG	0.483000													5	50					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43777520	43777520	+	Silent	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:43777520T>C	ENST00000389420.3	-	31	4637	c.4638A>G	c.(4636-4638)tcA>tcG	p.S1546S		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1546	TSP type-1 13.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TTCTCTCACATGATGTTGAAC	0.343000													29	44					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57442099	57442099	+	Silent	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:57442099G>T	ENST00000442789.2	-	3	296	c.9C>A	c.(7-9)ctC>ctA	p.L3L	MYO1A_ENST00000300119.3_Silent_p.L3L	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	3	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						AACCTTCCAGGAGAGGCATGT	0.532000													8	34					5.18039e-06	5.94409e-06	1	1	0
CCL16	6360	broad.mit.edu	37	17	34305249	34305249	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:34305249C>T	ENST00000293275.3	-	2	202	c.127G>A	c.(127-129)Gag>Aag	p.E43K		NM_004590.2	NP_004581.1	O15467	CCL16_HUMAN	chemokine (C-C motif) ligand 16	43					cell-cell signaling|immune response|inflammatory response	extracellular space	chemoattractant activity|chemokine activity	p.E43K(1)		endometrium(1)|lung(2)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AACACTTTCTCATAATACTTC	0.502000													14	196					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108627108	108627108	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:108627108G>A	ENST00000264047.2	+	9	1810	c.1534G>A	c.(1534-1536)Gat>Aat	p.D512N	SLC5A7_ENST00000409059.1_Missense_Mutation_p.D512N|SLC5A7_ENST00000540517.1_Missense_Mutation_p.D407N	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	512					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	ACCTAAATTAGATGTATTTGA	0.328000													4	53					0	0	1	0	0
CSN2	1447	broad.mit.edu	37	4	70823091	70823091	+	Silent	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:70823091A>T	ENST00000353151.3	-	5	587	c.576T>A	c.(574-576)ccT>ccA	p.P192P		NM_001891.2	NP_001882.1	P05814	CASB_HUMAN	casein beta	192					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|skin(2)	12						GGGCTTGAACAGGCACAGCTC	0.557000													15	38					0	0	1	0	0
GOLGB1	2804	broad.mit.edu	37	3	121414349	121414349	+	Missense_Mutation	SNP	T	T	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:121414349T>G	ENST00000393667.3	-	13	5131	c.5021A>C	c.(5020-5022)cAa>cCa	p.Q1674P	GOLGB1_ENST00000340645.5_Missense_Mutation_p.Q1669P	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1669					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		CTCCATTTCTTGCTCAGCTTC	0.433000													17	187					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116930952	116930952	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:116930952A>G	ENST00000355044.3	+	8	1376	c.1250A>G	c.(1249-1251)cAt>cGt	p.H417R	ATRNL1_ENST00000529665.1_3'UTR|ATRNL1_ENST00000527407.1_Missense_Mutation_p.I388V	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	417						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CATTCAGCACATATTATGGAG	0.368000													41	84					0	0	1	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4448613	4448613	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:4448613C>G	ENST00000254718.4	-	16	2407	c.2101G>C	c.(2101-2103)Gag>Cag	p.E701Q	MYBBP1A_ENST00000381556.2_Missense_Mutation_p.E701Q			Q9BQG0	MBB1A_HUMAN	MYB binding protein (P160) 1a	701					nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)	24						CGGTCATTCTCATCCTCACTG	0.672000													3	34					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40939347	40939347	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:40939347G>T	ENST00000246914.5	+	7	1549	c.1528G>T	c.(1528-1530)Gta>Tta	p.V510L	WNK4_ENST00000587705.1_3'UTR	NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	510					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		GGCCCGTGCAGTACGTGAACG	0.592000													13	49					9.31168e-06	1.06062e-05	1	1	0
HIST1H2AJ	8331	broad.mit.edu	37	6	27782162	27782162	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:27782162C>G	ENST00000333151.3	-	1	445	c.357G>C	c.(355-357)aaG>aaC	p.K119N		NM_021066.2	NP_066544.1	Q99878	H2A1J_HUMAN	histone cluster 1, H2aj	119					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	11						TCTCAGTTTTCTTTGGCAGCA	0.493000													13	185					0	0	1	0	0
SP100	6672	broad.mit.edu	37	2	231379989	231379989	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:231379989G>A	ENST00000264052.5	+	25	2629	c.2274G>A	c.(2272-2274)gaG>gaA	p.E758E	SP100_ENST00000340126.4_Intron	NM_003113.3	NP_003104.2	P23497	SP100_HUMAN	SP100 nuclear antigen	758					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CTAAAGGGGAGAAAAAAAAGA	0.418000													14	66					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170044658	170044658	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:170044658G>A	ENST00000263816.3	-	49	9435	c.9150C>T	c.(9148-9150)gtC>gtT	p.V3050V		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3050	LDL-receptor class A 24.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCTCATCACAGACGAAGGTTT	0.512000													8	85					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34042925	34042925	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:34042925A>T	ENST00000373381.4	-	49	7723	c.7547T>A	c.(7546-7548)cTg>cAg	p.L2516Q		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2518	Sushi 14.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTCGCTCCACAGGTGGTAGCC	0.617000													10	71					0	0	1	0	0
OR8U1	219417	broad.mit.edu	37	11	56143344	56143344	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:56143344T>A	ENST00000302270.1	+	1	245	c.245T>A	c.(244-246)cTt>cAt	p.L82H		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					CCCAAAATGCTTGGGAATTTC	0.388000													57	164					0	0	1	0	0
OR5B3	441608	broad.mit.edu	37	11	58170112	58170112	+	Nonsense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:58170112G>C	ENST00000309403.2	-	1	770	c.771C>G	c.(769-771)taC>taG	p.Y257*		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TGGGTTGTAAGTACATGAAGA	0.458000													25	77					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66190200	66190200	+	Silent	SNP	A	A	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:66190200A>C	ENST00000311034.2	+	4	662	c.486A>C	c.(484-486)gcA>gcC	p.A162A		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	162					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						GCCAGAGTGCAGGCAACAAAC	0.552000													7	75					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102134115	102134115	+	Missense_Mutation	SNP	A	A	G	rs141469398		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:102134115A>G	ENST00000369138.1	+	6	1328	c.838A>G	c.(838-840)Aga>Gga	p.R280G	GRIK2_ENST00000421544.1_Missense_Mutation_p.R280G|GRIK2_ENST00000413795.1_Missense_Mutation_p.R280G|GRIK2_ENST00000369137.3_Missense_Mutation_p.R280G|GRIK2_ENST00000318991.6_Missense_Mutation_p.R280G|GRIK2_ENST00000369134.4_Missense_Mutation_p.R231G|GRIK2_ENST00000358361.3_Missense_Mutation_p.R280G	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	280					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GACAGGGTTCAGAATATTAAA	0.428000													8	45					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248039777	248039777	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:248039777G>T	ENST00000366481.3	+	6	1495	c.1447G>T	c.(1447-1449)Gat>Tat	p.D483Y	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	483						intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGATGTAAGAGATGATCATCT	0.433000													14	43					4.3838e-07	5.14381e-07	1	1	0
TMPRSS7	344805	broad.mit.edu	37	3	111795984	111795984	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:111795984C>T	ENST00000452346.2	+	16	2220	c.2217C>T	c.(2215-2217)caC>caT	p.H739H	TMPRSS7_ENST00000419127.1_Silent_p.H613H			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	739	Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GGCGAAGACACGAAGCAGGTG	0.507000													9	62					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	21997461	21997461	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:21997461G>T	ENST00000261200.4	-	26	3270	c.3271C>A	c.(3271-3273)Ctg>Atg	p.L1091M	RP11-729I10.2_ENST00000539874.1_RNA|ABCC9_ENST00000261201.4_Missense_Mutation_p.L1091M|ABCC9_ENST00000345162.2_Missense_Mutation_p.L1055M	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	1091	ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTGAGAATCAGTCCCAGGGGT	0.363000													16	122					1.00905e-13	1.32739e-13	1	1	0
FBXL17	64839	broad.mit.edu	37	5	107684233	107684233	+	Splice_Site	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:107684233T>C	ENST00000542267.1	-	4	1781		c.e4-2		FBXL17_ENST00000496714.1_Splice_Site|FBXL17_ENST00000359660.5_Splice_Site	NM_001163315.2	NP_001156787.2	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17											endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		TGAGCCCAGCTGTAAACAAAC	0.358000													7	37					0	0	1	0	0
FOCAD	54914	broad.mit.edu	37	9	20717839	20717839	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:20717839C>T	ENST00000380249.1	+	5	468	c.104C>T	c.(103-105)tCa>tTa	p.S35L	FOCAD_ENST00000338382.6_Missense_Mutation_p.S35L	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	35						integral to membrane	binding										aatggtttttcAGAAAAGATT	0.343000													3	26					0	0	1	0	0
MMP14	4323	broad.mit.edu	37	14	23315054	23315054	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:23315054G>C	ENST00000311852.6	+	10	1816	c.1555G>C	c.(1555-1557)Gag>Cag	p.E519Q	MMP14_ENST00000548162.1_Intron	NM_004995.2	NP_004986.1	P50281	MMP14_HUMAN	matrix metallopeptidase 14 (membrane-inserted)	519						extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		TGAGGGGACTGAGGAGGAGAC	0.657000													4	65					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48690480	48690480	+	Silent	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:48690480C>G	ENST00000544264.1	-	10	5869	c.5589G>C	c.(5587-5589)cgG>cgC	p.R1863R	CELSR3_ENST00000164024.4_Silent_p.R1863R			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	1863	Laminin G-like 2.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CATGGTGGCCCCGCCGGCCAC	0.622000													33	35					0	0	1	0	0
FETUB	26998	broad.mit.edu	37	3	186358298	186358298	+	Nonsense_Mutation	SNP	G	G	T	rs148037844		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:186358298G>T	ENST00000265029.3	+	1	150	c.49G>T	c.(49-51)Gga>Tga	p.G17*	FETUB_ENST00000539949.1_Intron|FETUB_ENST00000382134.3_Nonsense_Mutation_p.G17*|FETUB_ENST00000382136.3_Nonsense_Mutation_p.G17*|FETUB_ENST00000450521.1_Nonsense_Mutation_p.G17*|FETUB_ENST00000488561.1_3'UTR	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	17						extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		CCTGTGCTGCGGAGCAATGTC	0.617000													18	238					1.56452e-12	2.02954e-12	1	1	0
ACTC1	70	broad.mit.edu	37	15	35082648	35082648	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr15:35082648C>G	ENST00000290378.4	-	7	1754	c.1099G>C	c.(1099-1101)Gca>Cca	p.A367P	RP11-814P5.1_ENST00000503496.1_RNA	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	367					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		GATGGGCCTGCCTCATCGTAC	0.512000													19	59					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240085567	240085567	+	Silent	SNP	A	A	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:240085567A>G	ENST00000345617.3	-	6	1334	c.543T>C	c.(541-543)aaT>aaC	p.N181N	HDAC4_ENST00000541256.1_Silent_p.N150N	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	181	Interaction with MEF2A.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		CCTTCTTTTTATTGAGGACAA	0.567000													19	48					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248366854	248366854	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:248366854C>A	ENST00000456743.1	+	1	523	c.485C>A	c.(484-486)gCa>gAa	p.A162E		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GATGTTGTAGCAACATTTTCC	0.443000													15	296					3.27435e-08	3.8712e-08	1	1	0
IGKV2D-24	28885	broad.mit.edu	37	2	90044247	90044247	+	RNA	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:90044247C>A	ENST00000462693.1	+	0	198																											ATGGAAACACCTACTTGAGTT	0.537000													44	102					1.06522e-23	1.46311e-23	1	1	0
MAGED1	9500	broad.mit.edu	37	X	51640673	51640673	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:51640673C>T	ENST00000375695.2	+	7	1838	c.1685C>T	c.(1684-1686)aCt>aTt	p.T562I	MAGED1_ENST00000326587.7_Missense_Mutation_p.T506I|MAGED1_ENST00000494718.1_3'UTR|MAGED1_ENST00000375722.1_Missense_Mutation_p.T506I|MAGED1_ENST00000375772.3_Missense_Mutation_p.T506I	NM_001005333.1	NP_001005333.1	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1	506	MAGE.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			breast(1)|endometrium(4)|large_intestine(10)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	32	Ovarian(276;0.236)					CGTGAATACACTGATGTTTAT	0.507000										Multiple Myeloma(10;0.10)			4	46					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219868828	219868828	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:219868828C>G	ENST00000341552.5	-	33	5484	c.5401G>C	c.(5401-5403)Gag>Cag	p.E1801Q	AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000453220.1_Missense_Mutation_p.E1801Q|CCDC108_ENST00000441968.1_Missense_Mutation_p.E1801Q	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1801	Glu-rich.					integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		tcatccctctcctcctccttc	0.567000													11	100					0	0	1	0	0
CAPN1	823	broad.mit.edu	37	11	64953739	64953739	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:64953739C>T	ENST00000527323.1	+	5	929	c.689C>T	c.(688-690)gCt>gTt	p.A230V	CAPN1_ENST00000533129.1_Missense_Mutation_p.A230V|CAPN1_ENST00000533820.1_Missense_Mutation_p.A230V|CAPN1_ENST00000279247.6_Missense_Mutation_p.A230V|CAPN1_ENST00000524773.1_Missense_Mutation_p.A230V			P07384	CAN1_HUMAN	calpain 1, (mu/I) large subunit	230	Calpain catalytic.				positive regulation of cell proliferation|proteolysis	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	13		Lung NSC(402;0.094)|Melanoma(852;0.16)		Lung(977;0.00168)|LUSC - Lung squamous cell carcinoma(976;0.00813)		TTGCGCAAGGCTCCCAGTGAC	0.622000													7	11					0	0	1	0	0
NLRP6	171389	broad.mit.edu	37	11	281208	281208	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:281208G>C	ENST00000534750.1	+	4	1679	c.1474G>C	c.(1474-1476)Gag>Cag	p.E492Q	NLRP6_ENST00000312165.5_Missense_Mutation_p.E492Q	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	492	NACHT.					cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		GCTGGAGACAGAGGTCACCTA	0.622000													5	109					0	0	1	0	0
UBA6	55236	broad.mit.edu	37	4	68506893	68506893	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:68506893G>A	ENST00000322244.4	-	18	1589	c.1530C>T	c.(1528-1530)ttC>ttT	p.F510F		NM_018227.5	NP_060697.4	A0AVT1	UBA6_HUMAN	ubiquitin-like modifier activating enzyme 6	510					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						GACGAAATAGGAACTGTCTAT	0.279000													12	135					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79320937	79320937	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:79320937C>T	ENST00000428286.1	-	8	6376	c.5176G>A	c.(5176-5178)Gag>Aag	p.E1726K	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E2085K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2085					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TCAGGATTCTCACCATCTGCT	0.488000													11	169					0	0	1	0	0
IL20RB	53833	broad.mit.edu	37	3	136699372	136699372	+	Silent	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:136699372C>G	ENST00000329582.4	+	2	402	c.153C>G	c.(151-153)ctC>ctG	p.L51L	IL20RB_ENST00000484501.1_Intron|IL20RB_ENST00000309741.5_Silent_p.L4L|IL20RB-AS1_ENST00000462176.2_RNA	NM_144717.3	NP_653318.2	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta	51	Fibronectin type-III 1.					integral to membrane	receptor activity			kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14						TGAAGCATCTCTTGATGTGGA	0.488000													8	149					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183635269	183635269	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:183635269G>T	ENST00000511685.1	+	13	2374	c.2251G>T	c.(2251-2253)Gga>Tga	p.G751*	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Nonsense_Mutation_p.G751*					teneurin transmembrane protein 3																		CAACAGCAATGGAAGATGTAC	0.473000													11	47					0.00010058	0.000110002	1	1	0
PROSER1	80209	broad.mit.edu	37	13	39600484	39600484	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr13:39600484G>C	ENST00000352251.3	-	6	1243	c.410C>G	c.(409-411)tCt>tGt	p.S137C	PROSER1_ENST00000350125.3_Missense_Mutation_p.S115C	NM_025138.3	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	137																	TCCACAAGAAGATATCATAGC	0.388000													6	42					0	0	1	0	0
ILF3	3609	broad.mit.edu	37	19	10799240	10799240	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:10799240G>T	ENST00000449870.1	+	19	2766	c.2449G>T	c.(2449-2451)Gga>Tga	p.G817*	ILF3_ENST00000586544.1_3'UTR|ILF3_ENST00000588657.1_Nonsense_Mutation_p.G817*|ILF3_ENST00000318511.3_Nonsense_Mutation_p.G813*|ILF3_ENST00000590261.1_Nonsense_Mutation_p.G813*	NM_017620.2	NP_060090.2	Q12906	ILF3_HUMAN	interleukin enhancer binding factor 3, 90kDa	813	Interaction with PRMT1.				M phase|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleolus|ribonucleoprotein complex	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31			Epithelial(33;6.86e-06)|all cancers(31;1.65e-05)			CAGTGGTAGTGGAGGCCGAAG	0.662000													14	79					1.67942e-08	2.00585e-08	1	1	0
TTN	7273	broad.mit.edu	37	2	179598581	179598581	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:179598581C>T	ENST00000589042.1	-	53	15759	c.15535G>A	c.(15535-15537)Gca>Aca	p.A5179T	TTN_ENST00000591111.1_Missense_Mutation_p.A4862T|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.A3935T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4862	Ig-like 32.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCCTAGTGCAATCAAATCA	0.423000													8	75					0	0	1	0	0
ZNF131	7690	broad.mit.edu	37	5	43161564	43161564	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:43161564G>T	ENST00000509634.1	+	4	1041	c.585G>T	c.(583-585)caG>caT	p.Q195H	ZNF131_ENST00000509156.1_Missense_Mutation_p.Q195H|ZNF131_ENST00000505606.2_Missense_Mutation_p.Q195H|ZNF131_ENST00000399534.1_Missense_Mutation_p.Q195H|ZNF131_ENST00000306938.4_Missense_Mutation_p.Q195H|ZNF131_ENST00000509931.1_Intron			P52739	ZN131_HUMAN	zinc finger protein 131	195						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	17						CTGCCAAGCAGTCCGTAAAGT	0.463000													11	57					5.50884e-06	6.29004e-06	1	1	0
OR10A6	390093	broad.mit.edu	37	11	7950125	7950125	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:7950125C>A	ENST00000309838.2	-	1	84	c.85G>T	c.(85-87)Gtg>Ttg	p.V29L		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AGGAAAGCCACAAAGAGCTGC	0.443000													5	86					0.000602214	0.000645032	1	1	0
NFAT5	10725	broad.mit.edu	37	16	69703977	69703977	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr16:69703977G>A	ENST00000349945.1	+	9	2737	c.1185G>A	c.(1183-1185)ctG>ctA	p.L395L	NFAT5_ENST00000566899.1_Silent_p.L395L|NFAT5_ENST00000432919.1_Silent_p.L489L|NFAT5_ENST00000567239.1_Silent_p.L489L|NFAT5_ENST00000354436.2_Silent_p.L471L|NFAT5_ENST00000393742.2_Silent_p.L395L	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	471	RHD.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						AGAACTTTCTGAAAGGAACTA	0.358000													8	48					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19967376	19967376	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr22:19967376T>C	ENST00000263207.3	-	6	1577	c.1286A>G	c.(1285-1287)tAt>tGt	p.Y429C	ARVCF_ENST00000401994.1_Missense_Mutation_p.Y366C|ARVCF_ENST00000406259.1_Missense_Mutation_p.Y429C|ARVCF_ENST00000344269.3_Missense_Mutation_p.Y366C|ARVCF_ENST00000406522.1_Missense_Mutation_p.Y366C	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	429					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					GTCGCGGCCATAGGAGAGGTT	0.711000													3	7					0	0	1	0	0
ZBTB41	360023	broad.mit.edu	37	1	197147607	197147607	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:197147607C>A	ENST00000367405.4	-	6	1780	c.1712G>T	c.(1711-1713)gGa>gTa	p.G571V	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	571					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						AGGCTTTTCTCCACTGTGGAT	0.308000													11	38					2.80697e-09	3.40482e-09	1	1	0
FAM129B	64855	broad.mit.edu	37	9	130289575	130289575	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:130289575G>A	ENST00000373312.3	-	3	426	c.213C>T	c.(211-213)ttC>ttT	p.F71F	FAM129B_ENST00000468379.1_5'UTR|FAM129B_ENST00000373314.3_Silent_p.F58F	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	71	PH.						protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						GGTTCCCCGAGAAGACGATGC	0.627000													3	33					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2939071	2939071	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:2939071C>A	ENST00000378404.2	+	1	1026	c.821C>A	c.(820-822)cCc>cAc	p.P274H		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	274						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		AGCCAGAGCCCCGGGCTCTCG	0.632000													21	59					1.40151e-16	1.87537e-16	1	1	0
ANKRD11	29123	broad.mit.edu	37	16	89348306	89348306	+	Missense_Mutation	SNP	C	C	T	rs145653946		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr16:89348306C>T	ENST00000301030.4	-	9	5104	c.4644G>A	c.(4642-4644)atG>atA	p.M1548I	ANKRD11_ENST00000378330.2_Missense_Mutation_p.M1548I	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1548	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCCCGTTGCTCATCTTCACTG	0.572000													4	56					0	0	1	0	0
OR6Y1	391112	broad.mit.edu	37	1	158517453	158517453	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:158517453G>T	ENST00000302617.3	-	1	442	c.443C>A	c.(442-444)aCa>aAa	p.T148K		NM_001005189.1	NP_001005189.1	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y, member 1	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TCCAGCCAGTGTGCCACAGAG	0.473000													13	51					1.61879e-10	2.03767e-10	1	1	0
FAM120A	23196	broad.mit.edu	37	9	96233642	96233642	+	Missense_Mutation	SNP	C	C	A	rs148997614	byFrequency	TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:96233642C>A	ENST00000277165.6	+	2	888	c.694C>A	c.(694-696)Cgt>Agt	p.R232S	FAM120A_ENST00000375389.3_Missense_Mutation_p.R232S|FAM120A_ENST00000340893.4_Missense_Mutation_p.R232S|FAM120A_ENST00000333936.5_Missense_Mutation_p.R232S	NM_014612.3	NP_055427.2	Q9NZB2	F120A_HUMAN	family with sequence similarity 120A	232						cytoplasm|plasma membrane	RNA binding			endometrium(5)|kidney(3)|large_intestine(8)|lung(12)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GAATCCAAATCGTTTTCCTAT	0.423000													6	57					0.0215528	0.0219763	1	1	0
ZP4	57829	broad.mit.edu	37	1	238053768	238053768	+	Silent	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:238053768T>A	ENST00000366570.4	-	1	326	c.168A>T	c.(166-168)atA>atT	p.I56I	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	56					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TACCCCAAGCTATTAGTACAG	0.478000													4	54					0	0	1	0	0
TFAP2B	7021	broad.mit.edu	37	6	50791168	50791168	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:50791168G>A	ENST00000263046.4	+	3	323	c.157G>A	c.(157-159)Ggc>Agc	p.G53S	TFAP2B_ENST00000489228.1_3'UTR|TFAP2B_ENST00000393655.3_Missense_Mutation_p.G44S			Q92481	AP2B_HUMAN	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	44	Gln/Pro-rich (transactivation domain).				nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)	40	Lung NSC(77;0.156)					CTCCCAGCTGGGCTCGGTGTC	0.677000													3	15					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525925	176525925	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:176525925C>G	ENST00000367662.3	+	2	1631	c.467C>G	c.(466-468)tCt>tGt	p.S156C	PAPPA2_ENST00000367661.3_Missense_Mutation_p.S156C	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	156					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TCCAAGGAGTCTCTAGGTGAG	0.547000													7	146					0	0	1	0	0
EPB41L3	23136	broad.mit.edu	37	18	5433526	5433526	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr18:5433526T>C	ENST00000341928.2	-	8	1194	c.854A>G	c.(853-855)cAt>cGt	p.H285R	EPB41L3_ENST00000400111.3_Missense_Mutation_p.H285R|EPB41L3_ENST00000544123.1_Missense_Mutation_p.H285R|EPB41L3_ENST00000342933.3_Missense_Mutation_p.H285R|EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000540638.2_Missense_Mutation_p.H285R	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	285	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						TTCCAAGAAATGCATCTCTGC	0.353000													3	28					0	0	1	0	0
WWC2	80014	broad.mit.edu	37	4	184210674	184210674	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:184210674G>A	ENST00000403733.3	+	21	3469	c.3270G>A	c.(3268-3270)ctG>ctA	p.L1090L	WWC2_ENST00000504005.1_Silent_p.L772L|WWC2_ENST00000508747.1_Silent_p.L218L|WWC2_ENST00000448232.2_Silent_p.L1114L|WWC2_ENST00000513834.1_Silent_p.L1041L	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1090										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		TGCAGGCGCTGAGGGACTTGC	0.577000													10	33					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197889242	197889242	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:197889242C>T	ENST00000367390.3	+	3	315	c.288C>T	c.(286-288)ctC>ctT	p.L96L	LHX9_ENST00000561173.1_Silent_p.L111L|LHX9_ENST00000367391.1_Silent_p.L96L|LHX9_ENST00000367387.4_Silent_p.L105L|LHX9_ENST00000337020.2_Silent_p.L105L	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	105	LIM zinc-binding 1.				motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						AGCTGGCCCTCGAGTCCGAGC	0.562000													22	254					0	0	1	0	0
AKR1D1	6718	broad.mit.edu	37	7	137782639	137782639	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:137782639G>A	ENST00000242375.3	+	4	448	c.406G>A	c.(406-408)Gag>Aag	p.E136K	AKR1D1_ENST00000411726.2_Missense_Mutation_p.E136K|AKR1D1_ENST00000468877.2_3'UTR|AKR1D1_ENST00000432161.1_Missense_Mutation_p.E136K	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	136					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						CCCTAGAGATGAGAATGGCAA	0.284000													6	95					0	0	1	0	0
HAUS3	79441	broad.mit.edu	37	4	2242367	2242367	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:2242367C>A	ENST00000243706.4	-	2	536	c.307G>T	c.(307-309)Gag>Tag	p.E103*	POLN_ENST00000515357.1_Intron|POLN_ENST00000511885.2_Intron|HAUS3_ENST00000506763.1_Nonsense_Mutation_p.E103*|HAUS3_ENST00000443786.2_Nonsense_Mutation_p.E103*	NM_024511.5	NP_078787.2	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	103					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						ACCTCATCCTCTAATTTCTCC	0.388000													8	77					0.00307968	0.00323921	1	1	0
AGRN	375790	broad.mit.edu	37	1	957815	957815	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:957815C>G	ENST00000379370.2	+	2	486	c.436C>G	c.(436-438)Ctg>Gtg	p.L146V		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	146	NtA.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CCTGCGGAACCTGGAGGAGGT	0.632000													25	51					0	0	1	0	0
HAUS3	79441	broad.mit.edu	37	4	2241950	2241950	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:2241950C>G	ENST00000243706.4	-	2	953	c.724G>C	c.(724-726)Gat>Cat	p.D242H	POLN_ENST00000515357.1_Intron|POLN_ENST00000511885.2_Intron|HAUS3_ENST00000506763.1_Missense_Mutation_p.D242H|HAUS3_ENST00000443786.2_Missense_Mutation_p.D242H	NM_024511.5	NP_078787.2	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	242					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GTCTGTATATCTAAAAGTTGA	0.368000													4	27					0	0	1	0	0
C19orf40	91442	broad.mit.edu	37	19	33464391	33464391	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:33464391T>C	ENST00000588258.1	+	3	276	c.166T>C	c.(166-168)Tgc>Cgc	p.C56R	C19orf40_ENST00000590281.1_Missense_Mutation_p.C56R|C19orf40_ENST00000590179.1_Intron|C19orf40_ENST00000589646.1_5'UTR	NM_152266.3	NP_689479.1	Q9BTP7	FAP24_HUMAN	chromosome 19 open reading frame 40	56					DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7	Esophageal squamous(110;0.137)					GTCGAACAGATGCTGCATTCT	0.413000								Direct reversal of damage					26	109					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45811307	45811307	+	Silent	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr21:45811307G>C	ENST00000397928.1	+	11	2038	c.1593G>C	c.(1591-1593)ctG>ctC	p.L531L	TRPM2_ENST00000300481.9_Silent_p.L531L|TRPM2_ENST00000397932.2_Silent_p.L531L|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000300482.5_Silent_p.L531L	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	531						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CCTCCTGCCTGTTCCACAGCA	0.642000													9	68					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94487322	94487322	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:94487322C>A	ENST00000375708.3	-	9	1652	c.1454G>T	c.(1453-1455)gGg>gTg	p.G485V	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Missense_Mutation_p.G345V	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	485	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GTAGACTTTCCCAAACCGGTC	0.587000													34	240					7.11191e-15	9.38209e-15	1	1	0
OR8U1	219417	broad.mit.edu	37	11	56143601	56143601	+	Missense_Mutation	SNP	T	T	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:56143601T>G	ENST00000302270.1	+	1	502	c.502T>G	c.(502-504)Tat>Gat	p.Y168D		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					CCGCCTCTCCTATTGCCACTC	0.453000													23	280					0	0	1	0	0
RMI1	80010	broad.mit.edu	37	9	86616726	86616726	+	Silent	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:86616726A>T	ENST00000325875.3	+	3	1157	c.825A>T	c.(823-825)tcA>tcT	p.S275S		NM_024945.2	NP_079221.2	Q9H9A7	RMI1_HUMAN	RecQ mediated genome instability 1	275					DNA replication	nucleus				biliary_tract(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						GTAGTTCCTCAAATACCATTC	0.388000													46	90					0	0	1	0	0
ZNF646	9726	broad.mit.edu	37	16	31090721	31090721	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr16:31090721G>A	ENST00000394979.2	+	1	3499	c.3076G>A	c.(3076-3078)Gag>Aag	p.E1026K	ZNF646_ENST00000300850.5_Missense_Mutation_p.E1026K			O15015	ZN646_HUMAN	zinc finger protein 646	1026					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						CAAGTCTCAAGAGGGAGCAGG	0.587000													14	135					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91465055	91465055	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:91465055G>A	ENST00000416354.1	+	2	76	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K	KIF20B_ENST00000371728.3_Missense_Mutation_p.E2K|KIF20B_ENST00000260753.4_Missense_Mutation_p.E2K|KIF20B_ENST00000394289.2_Missense_Mutation_p.E2K			Q96Q89	KI20B_HUMAN	kinesin family member 20B	2					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						TTGCAGAATGGAATCTAATTT	0.388000													18	108					0	0	1	0	0
RPLP0P2	113157	broad.mit.edu	37	11	61404333	61404333	+	RNA	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:61404333C>A	ENST00000496593.1	+	0	937					NR_002775.2																						AACGCCATGACGCGCAAGGCC	0.582000													10	28					0.00621372	0.00644846	1	1	0
FAM161B	145483	broad.mit.edu	37	14	74409272	74409272	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:74409272G>A	ENST00000286544.3	-	4	1459	c.1261C>T	c.(1261-1263)Ctg>Ttg	p.L421L	FAM161B_ENST00000534936.1_Silent_p.L358L	NM_152445.2	NP_689658.2			family with sequence similarity 161, member B											breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(2)	21						TTAGTGTGCAGAAACCCAAGC	0.557000													7	149					0	0	1	0	0
BTN3A3	10384	broad.mit.edu	37	6	26452203	26452203	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:26452203A>G	ENST00000244519.2	+	11	1562	c.1319A>G	c.(1318-1320)aAt>aGt	p.N440S	BTN3A3_ENST00000339789.4_Missense_Mutation_p.N398S|BTN3A3_ENST00000361232.3_Missense_Mutation_p.N391S	NM_006994.4	NP_008925.1	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3	440	B30.2/SPRY.					integral to membrane				cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30						ACTGATGGGAATAAGTATCGG	0.498000													7	92					0	0	1	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090737	238090737	+	RNA	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:238090737C>A	ENST00000450451.1	+	0	2243					NR_027247.2																						TACAGCTTCACCACCTCGGCC	0.617000													4	29					0.00024832	0.000269061	1	1	0
BBC3	27113	broad.mit.edu	37	19	47725046	47725046	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:47725046C>T	ENST00000449228.1	-	4	861	c.698G>A	c.(697-699)cGc>cAc	p.R233H	BBC3_ENST00000341983.4_3'UTR|BBC3_ENST00000300880.7_Missense_Mutation_p.R73H|BBC3_ENST00000439096.2_3'UTR	NM_001127240.2	NP_001120712.1	Q9BXH1	BBC3_HUMAN	BCL2 binding component 3	0					activation of caspase activity|activation of pro-apoptotic gene products|cellular response to hypoxia|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of growth|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|positive regulation of thymocyte apoptosis|protein insertion into mitochondrial membrane involved in induction of apoptosis|reduction of endoplasmic reticulum calcium ion concentration|release of cytochrome c from mitochondria|release of sequestered calcium ion into cytosol	cytosol|mitochondrial outer membrane	protein binding			endometrium(1)|lung(2)|skin(1)	4		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.000179)|OV - Ovarian serous cystadenocarcinoma(262;0.00029)|Epithelial(262;0.0103)|GBM - Glioblastoma multiforme(486;0.0234)		GTCCACCGGGCGGGTGCAGGC	0.652000													5	28					0	0	1	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220406155	220406155	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:220406155C>A	ENST00000358951.2	-	2	282	c.166G>T	c.(166-168)Gaa>Taa	p.E56*		NM_012414.3	NP_036546.2	Q9H2M9	RBGPR_HUMAN	RAB3 GTPase activating protein subunit 2 (non-catalytic)	56					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(131;0.0443)		TCTTGTGGTTCATTTTCTTCC	0.358000													21	60					6.44725e-10	7.94424e-10	1	1	0
ADH1A	124	broad.mit.edu	37	4	100208759	100208759	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:100208759C>G	ENST00000209668.2	-	2	195	c.82G>C	c.(82-84)Gag>Cag	p.E28Q	ADH1A_ENST00000511656.1_5'UTR|RP11-696N14.1_ENST00000500358.2_RNA	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	28					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	GGTGCAACCTCCACCTCCTCA	0.383000													6	52					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553937	140553937	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:140553937C>A	ENST00000231137.3	+	1	1695	c.1521C>A	c.(1519-1521)aaC>aaA	p.N507K		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		507	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTCCATCAACGCGGACAACG	0.697000													29	139					3.99451e-17	5.37589e-17	1	1	0
IRF3	3661	broad.mit.edu	37	19	50165692	50165692	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:50165692C>T	ENST00000597198.1	-	5	972	c.591G>A	c.(589-591)gtG>gtA	p.V197V	IRF3_ENST00000600911.1_Silent_p.V197V|IRF3_ENST00000600022.1_Silent_p.V51V|IRF3_ENST00000377139.3_Silent_p.V197V|IRF3_ENST00000309877.7_Silent_p.V197V|IRF3_ENST00000596765.1_Silent_p.V51V|IRF3_ENST00000598808.1_Silent_p.V51V|IRF3_ENST00000599223.1_Silent_p.V197V|IRF3_ENST00000593922.1_Silent_p.V51V|IRF3_ENST00000377135.4_Silent_p.V197V|IRF3_ENST00000596822.1_Silent_p.V51V|IRF3_ENST00000599144.1_Silent_p.V51V|IRF3_ENST00000601291.1_Silent_p.V197V			Q14653	IRF3_HUMAN	interferon regulatory factor 3	197					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|large_intestine(2)|lung(4)|ovary(2)|stomach(1)	10		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.02)		CTTCCCCCGGCACCAACAGCC	0.667000													6	10					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76603141	76603141	+	Missense_Mutation	SNP	T	T	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:76603141T>G	ENST00000287239.4	+	3	1015	c.526T>G	c.(526-528)Tat>Gat	p.Y176D	KAT6B_ENST00000372711.1_Missense_Mutation_p.Y176D|KAT6B_ENST00000372724.1_Missense_Mutation_p.Y176D|KAT6B_ENST00000372714.1_Missense_Mutation_p.Y176D|KAT6B_ENST00000372725.1_Missense_Mutation_p.Y176D	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	176	H15.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										CAGGGTCAATTATGGGAGCTT	0.557000													7	56					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26725264	26725264	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:26725264A>C	ENST00000272371.2	-	7	740	c.614T>G	c.(613-615)cTt>cGt	p.L205R	OTOF_ENST00000403946.3_Missense_Mutation_p.L205R	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	205					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGATGGTCAAGGTCTTCCAT	0.527000													4	15					0	0	1	0	0
SEL1L3	23231	broad.mit.edu	37	4	25785871	25785871	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:25785871C>T	ENST00000399878.3	-	14	2381	c.2259G>A	c.(2257-2259)ctG>ctA	p.L753L	SEL1L3_ENST00000264868.5_Silent_p.L718L|SEL1L3_ENST00000502949.1_Silent_p.L600L	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	753						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						CTTTCTTCATCAGCTCTAAGG	0.433000													14	140					0	0	1	0	0
DEPTOR	64798	broad.mit.edu	37	8	120942174	120942174	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:120942174G>A	ENST00000286234.5	+	3	551	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	DEPTOR_ENST00000523492.1_Intron	NM_022783.2	NP_073620.2	Q8TB45	DPTOR_HUMAN	DEP domain containing MTOR-interacting protein	141					intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	18						GAGGCTATATGAAAAGTATGT	0.418000													11	110					0	0	1	0	0
CRHBP	1393	broad.mit.edu	37	5	76251547	76251547	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:76251547G>A	ENST00000274368.4	+	4	825	c.403G>A	c.(403-405)Gag>Aag	p.E135K	CRHBP_ENST00000506501.1_Missense_Mutation_p.E135K	NM_001882.3	NP_001873.2	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	135					female pregnancy|learning or memory|signal transduction	soluble fraction				kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		CCCCTCAGCTGAGCGGTACAT	0.468000													6	41					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43262304	43262304	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:43262304G>C	ENST00000404209.4	-	3	655	c.559C>G	c.(559-561)Ctc>Gtc	p.L187V	PSG8_ENST00000401467.2_Intron|PSG8_ENST00000600709.1_5'UTR|PSG8_ENST00000406636.3_Missense_Mutation_p.L65V|PSG8_ENST00000306511.4_Missense_Mutation_p.L187V	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	187	Ig-like C2-type 1.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				GACATAGGGAGGCTCTGACCA	0.507000													79	275					0	0	1	0	0
SPATA5	166378	broad.mit.edu	37	4	124235184	124235184	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:124235184G>C	ENST00000274008.3	+	16	2716	c.2647G>C	c.(2647-2649)Gat>Cat	p.D883H		NM_145207.2	NP_660208.2	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	883					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24						TTTTTATGAAGATTATCAAGA	0.348000													4	37					0	0	1	0	0
IGKV3D-20	28874	broad.mit.edu	37	2	90077804	90077804	+	RNA	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:90077804C>A	ENST00000390270.2	+	0	125																											GCTTCTCTTCCTCCTGCTACT	0.542000													29	58					3.57733e-08	4.21872e-08	1	1	0
BDKRB2	624	broad.mit.edu	37	14	96707445	96707445	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:96707445G>T	ENST00000542454.2	+	3	3787	c.699G>T	c.(697-699)aaG>aaT	p.K233N	RP11-404P21.8_ENST00000553811.1_Intron|BDKRB2_ENST00000554311.1_Missense_Mutation_p.K260N|BDKRB2_ENST00000306005.3_Missense_Mutation_p.K260N|BDKRB2_ENST00000539359.1_Missense_Mutation_p.K233N			P30411	BKRB2_HUMAN	bradykinin receptor B2	260					arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		AGAAGTTCAAGGAGATCCAGA	0.552000													11	36					0.000978159	0.00104292	1	1	0
DOCK9	23348	broad.mit.edu	37	13	99462425	99462425	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr13:99462425C>G	ENST00000376460.1	-	47	5331	c.5251G>C	c.(5251-5253)Gag>Cag	p.E1751Q	DOCK9_ENST00000448493.2_3'UTR|DOCK9_ENST00000339416.2_Missense_Mutation_p.E1752Q	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	1752	DHR-2.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TCTCATACCTCAAAATCCCTC	0.483000													23	89					0	0	1	0	0
PWP2	5822	broad.mit.edu	37	21	45540513	45540513	+	Splice_Site	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr21:45540513T>C	ENST00000291576.7	+	12	1466	c.1337_splice	c.e12-1	p.Y447_splice		NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	447						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		TCTCTGCAGGTACCGAAACTT	0.642000													5	43					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237778090	237778090	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:237778090C>G	ENST00000366574.2	+	37	5979	c.5662C>G	c.(5662-5664)Cgg>Ggg	p.R1888G	RYR2_ENST00000542537.1_Missense_Mutation_p.R1872G|RYR2_ENST00000360064.6_Missense_Mutation_p.R1886G	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1888	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGGGGGCAAGCGGCCCAAGGA	0.517000													23	47					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17780381	17780381	+	Silent	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:17780381C>A	ENST00000428389.2	-	6	638	c.639G>T	c.(637-639)acG>acT	p.T213T	UNC13A_ENST00000550896.1_Silent_p.T125T|UNC13A_ENST00000519716.2_Silent_p.T125T|UNC13A_ENST00000552293.1_Silent_p.T125T|UNC13A_ENST00000551649.1_Silent_p.T125T|UNC13A_ENST00000252773.7_Silent_p.T125T			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	125					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						GCTCAAAGCGCGTGTCCAGGA	0.612000													6	16					0.0215528	0.0219763	1	1	0
PCDHGA1	56114	broad.mit.edu	37	5	140711919	140711919	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:140711919C>T	ENST00000517417.1	+	1	1668	c.1668C>T	c.(1666-1668)aaC>aaT	p.N556N	PCDHGA1_ENST00000378105.3_Silent_p.N556N	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACCAGAACGACAACGCGC	0.642000													11	209					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51701242	51701242	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:51701242G>A	ENST00000371117.3	-	51	8408	c.8133C>T	c.(8131-8133)gtC>gtT	p.V2711V	PKHD1_ENST00000340994.4_Silent_p.V2711V	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2711					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CCCGGAGAATGACTTGAACTT	0.408000													9	82					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66063351	66063351	+	Splice_Site	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:66063351C>A	ENST00000503581.1	-	9	1996	c.1459_splice	c.e9+1	p.G487_splice	EYS_ENST00000342421.5_Splice_Site_p.G487_splice|EYS_ENST00000370616.2_Splice_Site_p.G487_splice|EYS_ENST00000370621.3_Splice_Site_p.G487_splice|EYS_ENST00000370618.3_Splice_Site_p.G487_splice|EYS_ENST00000393380.2_Splice_Site_p.G487_splice	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	487					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						AATTTGTTACCTGCAAATCCC	0.333000													13	47					9.05144e-12	1.16769e-11	1	1	0
NKAIN1	79570	broad.mit.edu	37	1	31655426	31655426	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:31655426G>A	ENST00000373736.2	-	5	489	c.483C>T	c.(481-483)ttC>ttT	p.F161F	NKAIN1_ENST00000263693.1_Silent_p.F117F|NKAIN1_ENST00000398657.2_Silent_p.F90F	NM_024522.2	NP_078798.2	Q4KMZ8	NKAI1_HUMAN	Na+/K+ transporting ATPase interacting 1	161						integral to membrane|plasma membrane				breast(1)|cervix(1)|endometrium(1)|kidney(2)|ovary(1)|prostate(1)	7		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)|Breast(348;0.141)|all_neural(195;0.146)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0184)|READ - Rectum adenocarcinoma(331;0.148)		AGGCGAACACGAAGCCGAACA	0.632000													6	49					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132528737	132528737	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:132528737G>T	ENST00000333577.4	+	36	6683	c.6574G>T	c.(6574-6576)Gca>Tca	p.A2192S	EP400_ENST00000332482.4_Missense_Mutation_p.A2119S|EP400_ENST00000389562.2_Missense_Mutation_p.A2155S|EP400_ENST00000330386.6_Missense_Mutation_p.A2075S|EP400_ENST00000389561.2_Missense_Mutation_p.A2156S			Q96L91	EP400_HUMAN	E1A binding protein p400	2192					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		AGTGATGACTGCAGTGAGGGC	0.632000													10	35					2.80697e-09	3.40482e-09	1	1	0
CHRDL1	91851	broad.mit.edu	37	X	109924723	109924723	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:109924723C>G	ENST00000218054.4	-	10	1333	c.1137G>C	c.(1135-1137)tgG>tgC	p.W379C	CHRDL1_ENST00000372045.1_Missense_Mutation_p.W373C|CHRDL1_ENST00000482160.1_Missense_Mutation_p.W301C|CHRDL1_ENST00000394797.4_Missense_Mutation_p.W379C|CHRDL1_ENST00000372042.1_Missense_Mutation_p.W381C|CHRDL1_ENST00000434224.1_Missense_Mutation_p.W300C|CHRDL1_ENST00000444321.2_Missense_Mutation_p.W380C	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	373					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region				endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						TTCGAATAGTCCAAACGTGGA	0.448000													4	61					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73069253	73069253	+	RNA	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:73069253G>C	ENST00000429829.1	-	0	3335					NR_001564.2																						TCAATGCAAAGAGTTTTAGGT	0.428000													3	33					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735047	140735047	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:140735047G>A	ENST00000571252.1	+	1	280	c.280G>A	c.(280-282)Gag>Aag	p.E94K	PCDHGB1_ENST00000523390.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGACAGGGAGGAGCTCTGCGA	0.542000													5	67					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5041455	5041455	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:5041455G>C	ENST00000574788.1	+	21	3195	c.965G>C	c.(964-966)cGt>cCt	p.R322P	USP6_ENST00000332776.4_Missense_Mutation_p.R322P|USP6_ENST00000250066.6_Missense_Mutation_p.R322P|USP6_ENST00000304328.5_5'UTR			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	322					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						CTGTGGGCACGTCTGCGGAAC	0.552000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								40	61					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30349328	30349328	+	Missense_Mutation	SNP	A	A	G	rs140109047		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:30349328A>G	ENST00000327564.7	+	1	1305	c.1244A>G	c.(1243-1245)gAt>gGt	p.D415G	LRRC37B_ENST00000584368.1_Missense_Mutation_p.D400G|LRRC37B_ENST00000341671.7_Missense_Mutation_p.D388G|LRRC37B_ENST00000543378.2_Missense_Mutation_p.D306G|LRRC37B_ENST00000581786.1_3'UTR|LRRC37B_ENST00000394713.3_Missense_Mutation_p.D388G			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	388						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				AGGACTACAGATCCTCCTCCA	0.552000													44	136					0	0	1	0	0
PLAT	5327	broad.mit.edu	37	8	42036448	42036448	+	Silent	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:42036448G>T	ENST00000220809.4	-	13	1753	c.1497C>A	c.(1495-1497)ggC>ggA	p.G499G	PLAT_ENST00000519510.1_Silent_p.G436G|PLAT_ENST00000429710.2_Silent_p.G373G|PLAT_ENST00000429089.2_Silent_p.G499G|PLAT_ENST00000270189.6_3'UTR|PLAT_ENST00000524009.1_Silent_p.G410G|PLAT_ENST00000352041.3_Silent_p.G453G	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	499	Peptidase S1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CCTGGGGCCCGCCGCTCCGAG	0.592000													38	68					1.96642e-18	2.66179e-18	1	1	0
KLHL4	56062	broad.mit.edu	37	X	86869563	86869563	+	Nonsense_Mutation	SNP	T	T	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:86869563T>G	ENST00000373119.4	+	3	862	c.717T>G	c.(715-717)taT>taG	p.Y239*	KLHL4_ENST00000373114.4_Nonsense_Mutation_p.Y239*	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	239	BTB.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						TGGTGCAGTATGCTTACACAG	0.348000													6	22					0	0	1	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30872148	30872148	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:30872148G>A	ENST00000251071.5	-	13	2910	c.2160C>T	c.(2158-2160)ccC>ccT	p.P720P	CAPRIN2_ENST00000417045.1_Silent_p.P720P|CAPRIN2_ENST00000308433.5_Silent_p.P387P|CAPRIN2_ENST00000298892.5_Intron|CAPRIN2_ENST00000395805.2_Silent_p.P685P	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	720					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GCTTGCCTGGGGGAATTGCTG	0.493000													14	105					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47814742	47814742	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:47814742C>T	ENST00000289672.2	-	57	8599	c.8549G>A	c.(8548-8550)tGa>tAa	p.*2850*		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	0					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						CCAGGCTCCTCAGAAGTCCTT	0.443000													5	104					0	0	1	0	0
SHOX2	6474	broad.mit.edu	37	3	157815885	157815885	+	Silent	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:157815885G>C	ENST00000490689.2	-	5	2037	c.504C>G	c.(502-504)acC>acG	p.T168T	SHOX2_ENST00000441443.2_Silent_p.T168T|SHOX2_ENST00000483851.2_Silent_p.T297T|SHOX2_ENST00000425436.3_Silent_p.T309T|SHOX2_ENST00000389589.4_Silent_p.T333T			O60902	SHOX2_HUMAN	short stature homeobox 2	309					nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(10)|skin(3)|upper_aerodigestive_tract(1)	20			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			AGTTCTTGCTGGTGGTCTTGG	0.667000													16	228					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73521484	73521484	+	Silent	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:73521484G>T	ENST00000418310.1	+	8	1218	c.1116G>T	c.(1114-1116)ggG>ggT	p.G372G	LIMK1_ENST00000538333.3_Silent_p.G308G|LIMK1_ENST00000336180.2_Silent_p.G342G			P53667	LIMK1_HUMAN	LIM domain kinase 1	342	Protein kinase.				actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				TCATCCACGGGGAGGTGCTGG	0.672000													6	25					0.000157383	0.000171324	1	1	0
GAS2L3	283431	broad.mit.edu	37	12	101017696	101017696	+	Silent	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:101017696T>C	ENST00000537247.1	+	10	1755	c.801T>C	c.(799-801)tcT>tcC	p.S267S	GAS2L3_ENST00000539410.1_Silent_p.S371S|GAS2L3_ENST00000266754.5_Silent_p.S371S|GAS2L3_ENST00000547754.1_Silent_p.S371S			Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	371	GAR.				cell cycle arrest					endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35						CAGTCCGTTCTAAATTGCCAA	0.453000													44	95					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211455575	211455575	+	Silent	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:211455575T>C	ENST00000233072.5	+	9	1088	c.892T>C	c.(892-894)Tta>Cta	p.L298L	CPS1_ENST00000430249.2_Silent_p.L304L	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	298	Glutamine amidotransferase type-1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TACAGGAAACTTAATAACAGG	0.388000													7	57					0	0	1	0	0
PRAME	23532	broad.mit.edu	37	22	22893242	22893242	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr22:22893242G>A	ENST00000543184.1	-	3	1153	c.291C>T	c.(289-291)ttC>ttT	p.F97F	PRAME_ENST00000424204.2_Silent_p.F81F|PRAME_ENST00000398743.2_Silent_p.F97F|PRAME_ENST00000485532.1_5'UTR|PRAME_ENST00000406503.1_Silent_p.F97F|PRAME_ENST00000402697.1_Silent_p.F97F|PRAME_ENST00000539862.1_Silent_p.F81F|PRAME_ENST00000405655.3_Silent_p.F97F|PRAME_ENST00000398741.1_Silent_p.F97F	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	97					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		GCACAGCTTTGAAGGTCTCCA	0.592000													17	72					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113616159	113616159	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:113616159C>T	ENST00000361127.4	+	1	329	c.131C>T	c.(130-132)cCc>cTc	p.P44L		NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	44	LRRNT.					cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		GGTCTCTGCCCCGCGCCCTGC	0.657000											OREG0013684	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	114					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216420325	216420325	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:216420325G>T	ENST00000366943.2	-	13	2797	c.2411C>A	c.(2410-2412)cCt>cAt	p.P804H	USH2A_ENST00000366942.3_Missense_Mutation_p.P804H|USH2A_ENST00000307340.3_Missense_Mutation_p.P804H			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	804	Laminin EGF-like 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GACAGTCCCAGGGAGGGATCC	0.483000										HNSCC(13;0.011)			16	97					3.52763e-06	4.06766e-06	1	1	0
BAGE2	85319	broad.mit.edu	37	21	11038778	11038778	+	RNA	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr21:11038778G>C	ENST00000470054.1	-	0	1425									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTAATAGCTGGTTTACCCATG	0.398000													21	282					0	0	1	0	0
HS2ST1	9653	broad.mit.edu	37	1	87569262	87569262	+	Silent	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:87569262C>G	ENST00000370550.5	+	6	1197	c.834C>G	c.(832-834)ctC>ctG	p.L278L	HS2ST1_ENST00000356813.4_Silent_p.L252L|RP5-1052I5.2_ENST00000370548.2_Silent_p.L252L	NM_012262.3	NP_036394.1	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1	278						Golgi membrane|integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)	9		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		CTACTGAACTCTATCGCACAG	0.363000													9	95					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10243662	10243662	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:10243662C>A	ENST00000418404.3	-	16	2114	c.1951G>T	c.(1951-1953)Gtg>Ttg	p.V651L	RP11-401O9.3_ENST00000577743.1_RNA|MYH13_ENST00000570743.1_Missense_Mutation_p.V651L|MYH13_ENST00000252172.4_Missense_Mutation_p.V651L			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	651	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						ACGGCCGACACGGTCTGGAAA	0.507000													18	30					1.01871e-10	1.29277e-10	1	1	0
PDZD2	23037	broad.mit.edu	37	5	31983647	31983647	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:31983647G>C	ENST00000438447.1	+	3	1251	c.863G>C	c.(862-864)aGa>aCa	p.R288T	PDZD2_ENST00000282493.3_Missense_Mutation_p.R288T			O15018	PDZD2_HUMAN	PDZ domain containing 2	288					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GAAGTGGACAGAGGGACAGAG	0.507000													7	138					0	0	1	0	0
IGHG2	3501	broad.mit.edu	37	14	106110430	106110430	+	RNA	SNP	A	A	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:106110430A>G	ENST00000390545.2	-	0	305																											ACTCGACACAACATTTGCGCT	0.612000													28	90					0	0	1	0	0
ADAT2	134637	broad.mit.edu	37	6	143753700	143753700	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:143753700C>G	ENST00000606514.1	-	4	844	c.260G>C	c.(259-261)tGt>tCt	p.C87S	ADAT2_ENST00000237283.8_Missense_Mutation_p.C134S			Q7Z6V5	ADAT2_HUMAN	adenosine deaminase, tRNA-specific 2	134					tRNA processing		hydrolase activity|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)	8				OV - Ovarian serous cystadenocarcinoma(155;5.61e-06)|GBM - Glioblastoma multiforme(68;0.0115)		AACAGAGCCACAACCACCAAA	0.383000													7	53					0	0	1	0	0
CCDC11	220136	broad.mit.edu	37	18	47778106	47778106	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr18:47778106C>T	ENST00000398545.4	-	4	639	c.522G>A	c.(520-522)aaG>aaA	p.K174K		NM_145020.3	NP_659457.2	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	174										endometrium(1)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|pancreas(1)|skin(1)	20				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		CACACACCTTCTTCTGATGGA	0.468000													80	165					0	0	1	0	0
ACTN3	89	broad.mit.edu	37	11	66327497	66327497	+	RNA	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:66327497C>T	ENST00000504911.1	-	0	220				ACTN3_ENST00000513398.1_RNA|ACTN3_ENST00000502692.1_RNA																							CATCTGCGATCAGTGGGACAA	0.682000													3	6					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81053410	81053410	+	Splice_Site	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:81053410G>A	ENST00000334512.5	+	12	1802	c.1230_splice	c.e12+1	p.E410_splice	ZMIZ1_ENST00000478357.1_3'UTR	NM_020338.3	NP_065071.1	Q9ULJ6	ZMIZ1_HUMAN	zinc finger, MIZ-type containing 1	410	Pro-rich.				transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			ACCCTGGAGAGGTGAGTGCAG	0.632000													5	70					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12655861	12655861	+	Missense_Mutation	SNP	C	C	T	rs28730822		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:12655861C>T	ENST00000425538.1	+	10	1456	c.1256C>T	c.(1255-1257)aCg>aTg	p.T419M	MYOCD_ENST00000395988.1_Missense_Mutation_p.T323M|MYOCD_ENST00000343344.4_Missense_Mutation_p.T419M	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	419					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GGGGATATAACGACTGTCACT	0.567000													35	42					0	0	1	0	0
SLC32A1	140679	broad.mit.edu	37	20	37357005	37357005	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr20:37357005C>T	ENST00000217420.1	+	2	1564	c.1301C>T	c.(1300-1302)aCg>aTg	p.T434M		NM_080552.2	NP_542119.1	Q9H598	VIAAT_HUMAN	solute carrier family 32 (GABA vesicular transporter), member 1	434					neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|urinary_tract(1)	38		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TGGGGGCTGACGCTGCGCTGC	0.682000													8	29					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71318329	71318329	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr16:71318329C>A	ENST00000338099.5	-	3	1831	c.1495G>T	c.(1495-1497)Gga>Tga	p.G499*	FTSJD1_ENST00000434935.2_Nonsense_Mutation_p.G499*			Q8IYT2	FTSJ1_HUMAN		499						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AGTTTCTTTCCCTCCAAAATA	0.363000													32	40					1.06801e-11	1.374e-11	1	1	0
ADAMTS3	9508	broad.mit.edu	37	4	73185191	73185191	+	Splice_Site	SNP	A	A	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:73185191A>C	ENST00000286657.4	-	9	1246	c.1208_splice	c.e9-1	p.L404_splice		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	404	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TCCATTCCCAACCTAGAACAC	0.453000													6	30					0	0	1	0	0
RRP12	23223	broad.mit.edu	37	10	99139474	99139474	+	Silent	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:99139474C>A	ENST00000370992.4	-	14	1698	c.1587G>T	c.(1585-1587)gcG>gcT	p.A529A	RRP12_ENST00000536831.1_Silent_p.A247A|RRP12_ENST00000315563.6_Silent_p.A429A|RRP12_ENST00000414986.1_Silent_p.A468A	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	529						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		GGTCAAGAGCCGCCGTGTGGG	0.592000													19	43					4.35082e-09	5.26381e-09	1	1	0
WDR60	55112	broad.mit.edu	37	7	158715070	158715070	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:158715070C>T	ENST00000407559.3	+	16	2082	c.1924C>T	c.(1924-1926)Cga>Tga	p.R642*		NM_018051.4	NP_060521.4	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	642										NS(3)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(4)|lung(16)|ovary(2)	35	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		CTCCCTAGATCGAAAAGTATC	0.443000													4	44					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88761447	88761447	+	RNA	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:88761447G>C	ENST00000444431.1	+	0	2577				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										AATATTCCTTGATGGCAGCAC	0.373000													9	144					0	0	1	0	0
PRKD1	5587	broad.mit.edu	37	14	30135403	30135403	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:30135403A>T	ENST00000331968.5	-	3	644	c.415T>A	c.(415-417)Ttt>Att	p.F139I	PRKD1_ENST00000415220.2_Missense_Mutation_p.F139I	NM_002742.2	NP_002733.2	Q15139	KPCD1_HUMAN	protein kinase D1	139					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|lung(32)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	78	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		AAGTCTTCAAAGGTGGCGGAA	0.418000													8	113					0	0	1	0	0
SLC24A4	123041	broad.mit.edu	37	14	92911683	92911683	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:92911683T>A	ENST00000532405.1	+	8	906	c.680T>A	c.(679-681)gTg>gAg	p.V227E	SLC24A4_ENST00000298877.1_Missense_Mutation_p.V210E|SLC24A4_ENST00000531433.1_Missense_Mutation_p.V227E|SLC24A4_ENST00000393265.2_Missense_Mutation_p.V163E|SLC24A4_ENST00000351924.5_Missense_Mutation_p.V210E			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	227						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		GAACAAATTGTGTGGTAAGTT	0.348000													16	56					0	0	1	0	0
HLTF	6596	broad.mit.edu	37	3	148757822	148757822	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:148757822G>A	ENST00000310053.5	-	21	2691	c.2498C>T	c.(2497-2499)tCa>tTa	p.S833L	HLTF_ENST00000494055.1_Missense_Mutation_p.S833L|HLTF_ENST00000392912.2_Missense_Mutation_p.S833L|HLTF_ENST00000465259.1_Missense_Mutation_p.S832L	NM_003071.3|NM_139048.2	NP_003062.2|NP_620636.1	Q14527	HLTF_HUMAN	helicase-like transcription factor	833					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CTTTACCTTTGAACTGGATGT	0.313000													4	31					0	0	1	0	0
DDX24	57062	broad.mit.edu	37	14	94526680	94526680	+	Silent	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:94526680C>A	ENST00000330836.5	-	5	1808	c.1677G>T	c.(1675-1677)acG>acT	p.T559T	DDX24_ENST00000555054.1_Silent_p.T516T|DDX24_ENST00000544005.1_Silent_p.T309T	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	559					RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		GCGTCTCCACCGTGGCCTCAT	0.473000													24	74					6.44725e-10	7.94424e-10	1	1	0
OSBPL1A	114876	broad.mit.edu	37	18	21761174	21761174	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr18:21761174A>G	ENST00000319481.3	-	19	1953	c.1747T>C	c.(1747-1749)Tac>Cac	p.Y583H	OSBPL1A_ENST00000357041.4_Missense_Mutation_p.Y201H|OSBPL1A_ENST00000399443.3_Missense_Mutation_p.Y70H	NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	583					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					TGCTCCATGTATTCAGTTAGG	0.428000													3	28					0	0	1	0	0
FBXL3	26224	broad.mit.edu	37	13	77589595	77589595	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr13:77589595C>T	ENST00000355619.5	-	4	916	c.592G>A	c.(592-594)Gat>Aat	p.D198N	FBXL3_ENST00000477982.1_5'UTR	NM_012158.2	NP_036290.1	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	198					regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|urinary_tract(1)	16		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)		TTGAGTGTATCACTATTGTTG	0.403000													12	88					0	0	1	0	0
ZNF335	63925	broad.mit.edu	37	20	44577669	44577669	+	Missense_Mutation	SNP	C	C	T	rs142441368		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr20:44577669C>T	ENST00000322927.2	-	28	4052	c.3952G>A	c.(3952-3954)Gag>Aag	p.E1318K	ZNF335_ENST00000426788.1_Missense_Mutation_p.E1163K	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	1318	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GGCACTGTCTCGTCTGTACCA	0.612000													4	63					0	0	1	0	0
MAGEB2	4113	broad.mit.edu	37	X	30237513	30237513	+	Silent	SNP	A	A	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:30237513A>G	ENST00000378988.4	+	2	917	c.816A>G	c.(814-816)caA>caG	p.Q272Q		NM_002364.4	NP_002355.2	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	272	MAGE.						protein binding			breast(1)|large_intestine(3)|lung(17)|ovary(1)|skin(1)	23						CACGCTTTCAATTCCTGTGGG	0.527000													14	18					0	0	1	0	0
LPCAT3	10162	broad.mit.edu	37	12	7087520	7087520	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:7087520G>A	ENST00000261407.4	-	9	1108	c.1023C>T	c.(1021-1023)acC>acT	p.T341T	LPCAT3_ENST00000535021.1_Intron|U47924.19_ENST00000564245.1_RNA	NM_005768.5	NP_005759.4	Q6P1A2	MBOA5_HUMAN	lysophosphatidylcholine acyltransferase 3	341					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(2)	17						CCCAGGCGTTGGTGTTGATGT	0.577000													8	152					0	0	1	0	0
A2ML1	144568	broad.mit.edu	37	12	9006759	9006759	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:9006759G>A	ENST00000299698.7	+	21	2806	c.2626G>A	c.(2626-2628)Gac>Aac	p.D876N	A2ML1_ENST00000539547.1_Missense_Mutation_p.D385N	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	720						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						AAAGATTCTGGACAGCAATGA	0.473000													8	41					0	0	1	0	0
KRT77	374454	broad.mit.edu	37	12	53086232	53086232	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:53086232C>A	ENST00000341809.3	-	7	1428	c.1400G>T	c.(1399-1401)cGc>cTc	p.R467L	KRT77_ENST00000537195.1_Missense_Mutation_p.R234L	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	467	Coil 2.|Rod.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						CAGCAGCTGGCGGTAGGTGGC	0.632000													20	36					1.96292e-10	2.46421e-10	1	1	0
MAML3	55534	broad.mit.edu	37	4	140810658	140810658	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:140810658C>A	ENST00000509479.2	-	2	2788	c.1932G>T	c.(1930-1932)caG>caT	p.Q644H	MAML3_ENST00000327122.5_Missense_Mutation_p.Q488H|MAML3_ENST00000398940.1_Missense_Mutation_p.Q172H	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	640	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgttgct	0.587000													20	81					2.37509e-13	3.11564e-13	1	1	0
FRRS1L	23732	broad.mit.edu	37	9	111899750	111899750	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:111899750C>G	ENST00000374581.3	-	5	1019	c.1020G>C	c.(1018-1020)ttG>ttC	p.L340F		NM_014334.2	NP_055149.2	Q9P0K9	CI004_HUMAN	ferric-chelate reductase 1-like	340						integral to membrane											GGGTTCCCATCAATAGGTAGA	0.363000													5	81					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179414242	179414242	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:179414242G>T	ENST00000367618.3	+	16	2088	c.1701G>T	c.(1699-1701)gaG>gaT	p.E567D	AXDND1_ENST00000461179.2_3'UTR|AXDND1_ENST00000457238.2_Missense_Mutation_p.E567D	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	567										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						AAAGTTTGGAGGGGGAGATGC	0.353000													30	65					2.12542e-12	2.7495e-12	1	1	0
SLC9A2	6549	broad.mit.edu	37	2	103274377	103274377	+	Nonsense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:103274377C>G	ENST00000233969.2	+	2	786	c.644C>G	c.(643-645)tCa>tGa	p.S215*		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	215						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						AGCTTAATCTCAGCTGTCGAT	0.498000													19	223					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112455759	112455759	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:112455759C>T	ENST00000230538.7	-	26	3864	c.3467G>A	c.(3466-3468)aGg>aAg	p.R1156K	LAMA4_ENST00000522006.1_Missense_Mutation_p.R1149K|LAMA4_ENST00000389463.4_Missense_Mutation_p.R1149K|LAMA4_ENST00000424408.2_Missense_Mutation_p.R1149K	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	1156	Laminin G-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CTTGACATGCCTTCTGTCAAC	0.333000													16	46					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42477153	42477153	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:42477153C>T	ENST00000434000.1	-	9	2340	c.2058G>A	c.(2056-2058)ggG>ggA	p.G686G	GPATCH8_ENST00000591680.1_Silent_p.G764G			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	764	Lys-rich.					intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TGCCACTGCTCCCCTCTTCAG	0.582000													5	72					0	0	1	0	0
HCFC2	29915	broad.mit.edu	37	12	104458418	104458418	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:104458418G>C	ENST00000229330.4	+	1	184	c.80G>C	c.(79-81)cGa>cCa	p.R27P		NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	27					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						CACGGACACCGAGCGGTGGCC	0.677000													3	17					0	0	1	0	0
PAG1	55824	broad.mit.edu	37	8	81899639	81899639	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:81899639G>A	ENST00000220597.4	-	6	950	c.240C>T	c.(238-240)agC>agT	p.S80S		NM_018440.3	NP_060910.3	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid microdomains 1	80					epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(2)	11	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			TCTGCTCACTGCTGGCAGGAG	0.468000													8	71					0	0	1	0	0
NR3C2	4306	broad.mit.edu	37	4	149357510	149357510	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:149357510G>C	ENST00000355292.3	-	2	865	c.503C>G	c.(502-504)tCt>tGt	p.S168C	NR3C2_ENST00000344721.4_Missense_Mutation_p.S168C|NR3C2_ENST00000358102.3_Missense_Mutation_p.S168C|NR3C2_ENST00000512865.1_Missense_Mutation_p.S168C|NR3C2_ENST00000342437.4_Missense_Mutation_p.S168C|NR3C2_ENST00000511528.1_Missense_Mutation_p.S168C			P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	168	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	GGAGCTCCCAGAGTCAGACAT	0.478000													14	117					0	0	1	0	0
FADS6	283985	broad.mit.edu	37	17	72888695	72888695	+	Silent	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:72888695G>T	ENST00000310226.6	-	2	326	c.312C>A	c.(310-312)acC>acA	p.T104T		NM_178128.3	NP_835229.2	Q8N9I5	FADS6_HUMAN	fatty acid desaturase 6	110					fatty acid biosynthetic process	integral to membrane	oxidoreductase activity			endometrium(3)|kidney(1)|lung(4)	8	all_lung(278;0.172)|Lung NSC(278;0.207)					GTTTGGACTCGGTGAGGGCCC	0.592000													5	18					1.23904e-05	1.40786e-05	1	1	0
B4GALNT2	124872	broad.mit.edu	37	17	47246954	47246954	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:47246954C>G	ENST00000300404.2	+	11	1624	c.1565C>G	c.(1564-1566)tCt>tGt	p.S522C	B4GALNT2_ENST00000393354.2_Missense_Mutation_p.S462C|B4GALNT2_ENST00000504681.1_Missense_Mutation_p.S436C	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	522					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			GGTCACCAGTCTCGGTCTCCA	0.547000													9	82					0	0	1	0	0
KPNB1	3837	broad.mit.edu	37	17	45734268	45734268	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:45734268G>A	ENST00000290158.4	+	4	732	c.325G>A	c.(325-327)Gcc>Acc	p.A109T	KPNB1_ENST00000535458.2_5'UTR|KPNB1_ENST00000577918.1_3'UTR|KPNB1_ENST00000540627.1_5'UTR	NM_001276453.1|NM_002265.4	NP_001263382.1|NP_002256.2	Q14974	IMB1_HUMAN	karyopherin (importin) beta 1	109					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			breast(1)|ovary(1)|pancreas(1)|skin(1)	4						GCCTAGTTCTGCCTCACAGTG	0.448000													19	40					0	0	1	0	0
KCNH2	3757	broad.mit.edu	37	7	150648799	150648799	+	Missense_Mutation	SNP	G	G	A	rs121912504		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:150648799G>A	ENST00000392968.2	-	5	2514	c.1394C>T	c.(1393-1395)gCg>gTg	p.A465V	KCNH2_ENST00000430723.3_Missense_Mutation_p.A561V|KCNH2_ENST00000330883.4_Missense_Mutation_p.A221V|KCNH2_ENST00000262186.5_Missense_Mutation_p.A561V			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	561					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TAGCCAGTGCGCGATGAGCGC	0.642000													18	36					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127708341	127708341	+	Silent	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:127708341G>T	ENST00000368679.4	-	22	2901	c.2592C>A	c.(2590-2592)gcC>gcA	p.A864A		NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	864					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GAGTTGTTCTGGCCAGAGGAT	0.592000													10	17					2.74318e-10	3.42531e-10	1	1	0
VAV3	10451	broad.mit.edu	37	1	108160255	108160255	+	Splice_Site	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:108160255C>A	ENST00000370056.4	-	21	2189		c.e21-1		VAV3_ENST00000544443.1_Splice_Site|VAV3_ENST00000527011.1_Splice_Site|VAV3_ENST00000415432.2_Splice_Site|VAV3_ENST00000343258.4_Splice_Site	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor						angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		AATTTCTGCCCTAAGGAAAAA	0.373000													8	56					5.68852e-11	7.27819e-11	1	1	0
KRTAP5-1	387264	broad.mit.edu	37	11	1606004	1606004	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:1606004G>A	ENST00000382171.2	-	1	509	c.476C>T	c.(475-477)tCc>tTc	p.S159F	KRTAP5-AS1_ENST00000424148.1_RNA|KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000524947.1_RNA|KRTAP5-AS1_ENST00000532922.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	159	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCACCCACAGGAGCCACAGCC	0.652000													14	141					0	0	1	0	0
TUBB6	84617	broad.mit.edu	37	18	12325389	12325389	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr18:12325389T>A	ENST00000317702.5	+	4	835	c.601T>A	c.(601-603)Tgc>Agc	p.C201S	TUBB6_ENST00000591909.1_Intron|TUBB6_ENST00000591208.1_3'UTR|TUBB6_ENST00000590967.1_Intron			Q9BUF5	TBB6_HUMAN	tubulin, beta 6 class V	201					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)	14				READ - Rectum adenocarcinoma(1;0.0649)		CGAGACCTACTGCATCGACAA	0.602000													8	160					0	0	1	0	0
SEMA6B	10501	broad.mit.edu	37	19	4552560	4552560	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:4552560G>A	ENST00000586582.1	-	10	1173	c.863C>T	c.(862-864)gCg>gTg	p.A288V	SEMA6B_ENST00000586965.1_Missense_Mutation_p.A288V|SEMA6B_ENST00000301293.3_Missense_Mutation_p.A288V	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	288	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GTTGAGCCGCGCCTTCAGGAA	0.672000													4	17					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19959935	19959935	+	Splice_Site	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr22:19959935C>G	ENST00000263207.3	-	17	2933		c.e17-1		ARVCF_ENST00000401994.1_Splice_Site|ARVCF_ENST00000406259.1_Splice_Site|ARVCF_ENST00000344269.3_Splice_Site|ARVCF_ENST00000406522.1_Splice_Site	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome						cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					TTCTCGCCCTCTGCAAGGCAG	0.647000													4	40					0	0	1	0	0
STARD6	147323	broad.mit.edu	37	18	51858172	51858172	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr18:51858172G>T	ENST00000580990.2	-	3	267	c.47C>A	c.(46-48)tCg>tAg	p.S16*	STARD6_ENST00000307844.3_Silent_p.R109R|STARD6_ENST00000581310.1_Silent_p.R109R			P59095	STAR6_HUMAN	StAR-related lipid transfer (START) domain containing 6	218	START.				lipid transport		lipid binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)	8				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		ATAAAGTCTCGAGGGGAAATG	0.378000													24	55					6.44725e-10	7.94424e-10	1	1	0
TTN	7273	broad.mit.edu	37	2	179614618	179614618	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:179614618C>T	ENST00000360870.5	-	46	12731	c.12509G>A	c.(12508-12510)tGt>tAt	p.C4170Y	TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3514							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCCTTCTCTACACCTGGCATG	0.378000													22	53					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44664506	44664506	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr20:44664506G>A	ENST00000454036.1	+	4	515	c.439G>A	c.(439-441)Gtg>Atg	p.V147M	SLC12A5_ENST00000372315.1_Missense_Mutation_p.V124M|SLC12A5_ENST00000243964.3_Missense_Mutation_p.V124M|SLC12A5_ENST00000539566.1_Missense_Mutation_p.V124M	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	147					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CACCTGGGTGGTGGGCATTGC	0.622000													20	35					0	0	1	0	0
OR6K3	391114	broad.mit.edu	37	1	158687584	158687584	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:158687584C>T	ENST00000368146.1	-	1	369	c.370G>A	c.(370-372)Gaa>Aaa	p.E124K	OR6K3_ENST00000368145.1_Missense_Mutation_p.E108K			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					TCTGAGTTTTCAAGTGAGTGG	0.498000													11	211					0	0	1	0	0
GJA4	2701	broad.mit.edu	37	1	35259992	35259992	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:35259992G>T	ENST00000342280.4	+	2	266	c.178G>T	c.(178-180)Ggc>Tgc	p.G60C		NM_002060.2	NP_002051.2	P35212	CXA4_HUMAN	gap junction protein, alpha 4, 37kDa	60					cell-cell junction assembly	integral to plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(4)|stomach(1)	14		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				GGCCCAGCCAGGCTGCACCAA	0.602000													11	68					3.07112e-06	3.55003e-06	1	1	0
ZAK	51776	broad.mit.edu	37	2	174086214	174086214	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:174086214G>C	ENST00000338983.3	+	12	1519	c.1324G>C	c.(1324-1326)Gat>Cat	p.D442H	MLTK_ENST00000375213.3_Intron|MLTK_ENST00000539448.1_Missense_Mutation_p.D442H|MLK7-AS1_ENST00000423106.2_RNA|MLTK_ENST00000409176.2_Intron|MLTK_ENST00000431503.2_Missense_Mutation_p.D341H|MLK7-AS1_ENST00000422703.1_RNA	NM_133646.2	NP_598407.1																					tgatgatgatgatgacggtga	0.388000													4	36					0	0	1	0	0
P2RX1	5023	broad.mit.edu	37	17	3808613	3808613	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:3808613G>A	ENST00000225538.3	-	2	460	c.186C>T	c.(184-186)atC>atT	p.I62I		NM_002558.2	NP_002549.1	P51575	P2RX1_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 1	62					platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	13				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		AGACACTGCTGATGAGGCCGC	0.632000													4	73					0	0	1	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4967199	4967199	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrY:4967199G>T	ENST00000333703.4	+	5	2060	c.1547G>T	c.(1546-1548)aGt>aTt	p.S516I	PCDH11Y_ENST00000362095.5_Missense_Mutation_p.S527I|PCDH11Y_ENST00000215473.6_Missense_Mutation_p.S527I	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	527	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GATGCAGACAGTGGGCCTAAT	0.468000													3	24					0.004672	0.00487014	1	1	0
TUBA1C	84790	broad.mit.edu	37	12	49666960	49666960	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:49666960G>A	ENST00000301072.6	+	4	1575	c.1300G>A	c.(1300-1302)Gag>Aag	p.E434K	RP11-161H23.5_ENST00000550468.2_RNA|TUBA1C_ENST00000541364.1_Missense_Mutation_p.E504K	NM_032704.3	NP_116093.1	Q9BQE3	TBA1C_HUMAN	tubulin, alpha 1c	434					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			endometrium(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)	13						GGATTATGAGGAGGTTGGAGC	0.498000													14	131					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2433468	2433468	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:2433468C>T	ENST00000452833.1	-	16	2385	c.2377G>A	c.(2377-2379)Gag>Aag	p.E793K	TRPM5_ENST00000528453.1_Missense_Mutation_p.E791K|TRPM5_ENST00000533060.1_Missense_Mutation_p.E791K|TRPM5_ENST00000155858.6_Missense_Mutation_p.E791K			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	791						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGTGTGTCCTCGTCTGTGAAG	0.572000													9	131					0	0	1	0	0
CSPP1	79848	broad.mit.edu	37	8	68018141	68018141	+	Splice_Site	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:68018141G>T	ENST00000262210.5	+	8	1082	c.1049_splice	c.e8-1	p.A351_splice	CSPP1_ENST00000412460.1_Splice_Site_p.A57_splice	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	386						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TTTCTTTAGTGCTCCAGACAA	0.348000													16	23					1.5739e-10	1.98651e-10	1	1	0
TCEB3	6924	broad.mit.edu	37	1	24078182	24078182	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:24078182G>C	ENST00000418390.2	+	4	1436	c.1165G>C	c.(1165-1167)Gag>Cag	p.E389Q		NM_003198.2	NP_003189.2	Q14241	ELOA1_HUMAN	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)	389					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		CAAGGTAAAAGAGAAGGGTTC	0.458000											OREG0013232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	103					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182821	140182821	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:140182821C>T	ENST00000522353.2	+	1	2039	c.2039C>T	c.(2038-2040)tCc>tTc	p.S680F	PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.S680F|PCDHA2_ENST00000520672.2_Intron	NM_018906.2	NP_061729.1												p.S680C(2)		NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGCCTCGTCCCAGGCGTCC	0.647000													20	73					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900587	51900587	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:51900587G>T	ENST00000268919.4	+	1	349	c.193G>T	c.(193-195)Gtc>Ttc	p.V65F		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	65					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GGAGAAAGCAGTCAAAAAAGG	0.557000													39	115					2.05212e-20	2.80216e-20	1	1	0
RIN3	79890	broad.mit.edu	37	14	93118855	93118855	+	Silent	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:93118855G>T	ENST00000216487.7	+	6	1620	c.1461G>T	c.(1459-1461)gcG>gcT	p.A487A	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	487	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				GCACACAGGCGATGGCCTTGG	0.637000													15	59					2.32078e-09	2.82978e-09	1	1	0
DMWD	1762	broad.mit.edu	37	19	46287938	46287938	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:46287938T>A	ENST00000270223.6	-	4	1983	c.1938A>T	c.(1936-1938)gaA>gaT	p.E646D	AC011530.4_ENST00000593999.1_Intron|DMWD_ENST00000377735.3_Intron	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	646					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		gccaacttccttcccctgtct	0.572000													18	72					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113694842	113694842	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:113694842C>A	ENST00000297405.5	-	16	2750	c.2506G>T	c.(2506-2508)Gat>Tat	p.D836Y	CSMD3_ENST00000343508.3_Missense_Mutation_p.D796Y|CSMD3_ENST00000352409.3_Missense_Mutation_p.D836Y|CSMD3_ENST00000455883.2_Missense_Mutation_p.D732Y	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	836	Sushi 4.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATTCCAGGATCAGGGCATTCA	0.353000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	135					3.59834e-05	4.01056e-05	1	1	0
BRD1	23774	broad.mit.edu	37	22	50217642	50217642	+	Silent	SNP	G	G	A	rs138837185		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr22:50217642G>A	ENST00000216267.8	-	1	810	c.324C>T	c.(322-324)caC>caT	p.H108H	BRD1_ENST00000404760.1_Silent_p.H108H|BRD1_ENST00000404034.1_Silent_p.H108H|BRD1_ENST00000457780.2_Silent_p.H108H	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	108					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		CCGGCGTGCCGTGGGCGCTGG	0.607000													9	64					0	0	1	0	0
OPA1	4976	broad.mit.edu	37	3	193385012	193385012	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:193385012G>T	ENST00000361510.2	+	29	3160	c.2926G>T	c.(2926-2928)Ggt>Tgt	p.G976C	OPA1_ENST00000392438.3_Missense_Mutation_p.G921C|OPA1_ENST00000361715.2_Missense_Mutation_p.G940C|OPA1_ENST00000361908.3_Missense_Mutation_p.G958C|OPA1_ENST00000361150.2_Missense_Mutation_p.G922C|OPA1_ENST00000361828.2_Missense_Mutation_p.G939C	NM_130837.2	NP_570850.2	O60313	OPA1_HUMAN	optic atrophy 1 (autosomal dominant)	921					apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(4)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(2)	31	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		TGCTGAAGATGGTGAGAAGAA	0.378000													34	39					6.70999e-13	8.75297e-13	1	1	0
GAPDH	2597	broad.mit.edu	37	12	6646140	6646140	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:6646140G>T	ENST00000229239.5	+	5	957	c.291G>T	c.(289-291)gaG>gaT	p.E97D	GAPDH_ENST00000396858.1_Missense_Mutation_p.E55D|GAPDH_ENST00000396859.1_Missense_Mutation_p.E97D|GAPDH_ENST00000396861.1_Missense_Mutation_p.E97D|GAPDH_ENST00000396856.1_Missense_Mutation_p.E22D	NM_002046.4	NP_002037.2	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	97	Interaction with WARS.				gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|lung(4)	7					NADH(DB00157)	ACGTCGTGGAGTCCACTGGCG	0.632000													14	124					1.5842e-08	1.89698e-08	1	1	0
ZFP69B	65243	broad.mit.edu	37	1	40928765	40928765	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:40928765A>C	ENST00000411995.2	+	6	1484	c.1109A>C	c.(1108-1110)aAa>aCa	p.K370T	ZFP69B_ENST00000484445.1_3'UTR|ZFP69B_ENST00000361584.3_Missense_Mutation_p.K268T	NM_023070.2	NP_075558.2			ZFP69 zinc finger protein B																		GTATGTGAGAAAGCCTTCAGC	0.423000													4	45					0	0	1	0	0
IL36B	27177	broad.mit.edu	37	2	113786647	113786647	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:113786647G>A	ENST00000259213.4	-	4	237	c.130C>T	c.(130-132)Cat>Tat	p.H44Y	IL36B_ENST00000327407.2_Missense_Mutation_p.H44Y	NM_014438.3	NP_055253.2	Q9NZH7	IL36B_HUMAN	interleukin 36, beta	44					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			kidney(1)|ovary(1)|pancreas(1)	3						GCTATTAAATGAAGAGTGACT	0.438000													5	66					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5418344	5418344	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:5418344C>A	ENST00000345221.3	-	16	4574	c.4020G>T	c.(4018-4020)caG>caT	p.Q1340H	NLRP1_ENST00000354411.3_Missense_Mutation_p.Q1354H|NLRP1_ENST00000577119.1_Missense_Mutation_p.Q1310H|NLRP1_ENST00000262467.5_Intron|NLRP1_ENST00000269280.4_Missense_Mutation_p.Q1340H|NLRP1_ENST00000572272.1_Missense_Mutation_p.Q1384H	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	1384					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding	p.Q1384H(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GCTCTCGATACTGGTCCACAA	0.582000													9	25					2.74318e-10	3.42531e-10	1	1	0
SMIM21	284274	broad.mit.edu	37	18	73139445	73139445	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr18:73139445G>T	ENST00000584508.1	-	1	192	c.74C>A	c.(73-75)gCa>gAa	p.A25E	SMIM21_ENST00000579022.1_Missense_Mutation_p.A25E|SMIM21_ENST00000382638.3_Missense_Mutation_p.A25E					small integral membrane protein 21																		TCCCATTCCTGCAGAGTCTTG	0.498000													30	75					2.65835e-16	3.53689e-16	1	1	0
MS4A4A	51338	broad.mit.edu	37	11	60070084	60070084	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:60070084G>T	ENST00000355131.3	+	6	606	c.383G>T	c.(382-384)gGg>gTg	p.G128V	MS4A4A_ENST00000532114.1_Intron|MS4A4A_ENST00000337908.4_Missense_Mutation_p.G147V|MS4A4A_ENST00000395016.3_Missense_Mutation_p.G128V	NM_024021.3	NP_076926.2	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member 4A	147						integral to membrane	receptor activity	p.G128E(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(12)|prostate(1)|skin(4)	23						GCTGCATCAGGGATCTTAATC	0.393000													15	52					1.05317e-09	1.29089e-09	1	1	0
PCLO	27445	broad.mit.edu	37	7	82582194	82582194	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:82582194C>T	ENST00000423517.2	-	5	8412	c.8075G>A	c.(8074-8076)aGc>aAc	p.S2692N	PCLO_ENST00000333891.8_Missense_Mutation_p.S2692N	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2623					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGAAATGCTGCTGAGACCAAC	0.418000													4	49					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53074007	53074007	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:53074007C>G	ENST00000276480.7	-	14	2205	c.1522G>C	c.(1522-1524)Gat>Cat	p.D508H		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	508						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				ACTTGGGCATCAAAACTGGCA	0.433000													17	87					0	0	1	0	0
POU3F4	5456	broad.mit.edu	37	X	82763436	82763436	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:82763436A>T	ENST00000373200.2	+	1	168	c.104A>T	c.(103-105)cAg>cTg	p.Q35L	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	35					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						CGCAACCCTCAGAAACTTCTC	0.597000													9	8					0	0	1	0	0
PCSK1	5122	broad.mit.edu	37	5	95743963	95743963	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:95743963A>G	ENST00000311106.3	-	9	1397	c.1160T>C	c.(1159-1161)cTg>cCg	p.L387P	CTD-2337A12.1_ENST00000502645.2_RNA|PCSK1_ENST00000508626.1_Missense_Mutation_p.L340P|PCSK1_ENST00000513085.1_5'UTR	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	387	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCCAGCAGCCAGAGGTGCAGA	0.527000													7	20					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22173083	22173083	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:22173083C>A	ENST00000374695.3	-	63	8253	c.8174G>T	c.(8173-8175)aGc>aTc	p.S2725I	HSPG2_ENST00000430507.1_3'UTR	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	2725	Ig-like C2-type 12.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGGCATGGAGCTGCCAGGGGC	0.607000													4	67					0.150653	0.151301	1	1	0
NAV3	89795	broad.mit.edu	37	12	78513443	78513443	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:78513443G>A	ENST00000397909.2	+	15	3640	c.3467G>A	c.(3466-3468)aGa>aAa	p.R1156K	NAV3_ENST00000228327.6_Missense_Mutation_p.R1156K|NAV3_ENST00000266692.7_Missense_Mutation_p.R1156K|NAV3_ENST00000536525.2_Missense_Mutation_p.R1156K			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1156	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GGAGGCCACAGATCCAGTACC	0.542000										HNSCC(70;0.22)			8	78					0	0	1	0	0
DFNB59	494513	broad.mit.edu	37	2	179319183	179319183	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:179319183G>A	ENST00000409117.3	+	3	692	c.336G>A	c.(334-336)gtG>gtA	p.V112V	DFNB59_ENST00000375129.4_Silent_p.V112V	NM_001042702.3	NP_001036167.1	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	112					sensory perception of sound					breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			CCATTGCAGTGAAAGCTTCAT	0.348000													6	54					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79400611	79400611	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:79400611G>T	ENST00000264895.6	+	56	8622	c.8182G>T	c.(8182-8184)Ggc>Tgc	p.G2728C		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2723	Calx-beta 2.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCTAGAATCAGGCTCTGATTT	0.463000													7	22					0.248553	0.249086	1	1	0
TTLL9	164395	broad.mit.edu	37	20	30507720	30507720	+	Silent	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr20:30507720C>T	ENST00000375938.4	+	7	811	c.558C>T	c.(556-558)atC>atT	p.I186I	TTLL9_ENST00000310998.4_Silent_p.I136I|TTLL9_ENST00000375922.4_Intron|TTLL9_ENST00000375921.2_Intron|TTLL9_ENST00000535842.1_Silent_p.I186I|TTLL9_ENST00000375934.4_Silent_p.I168I			Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	186	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			TGAAGGACATCGTGGACTGGA	0.597000													4	70					0	0	1	0	0
ACER2	340485	broad.mit.edu	37	9	19435028	19435028	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:19435028C>G	ENST00000340967.2	+	4	475	c.449C>G	c.(448-450)tCt>tGt	p.S150C	ACER2_ENST00000380376.1_Missense_Mutation_p.S101C	NM_001010887.2	NP_001010887.2	Q5QJU3	ACER2_HUMAN	alkaline ceramidase 2	150					ceramide metabolic process|negative regulation of cell adhesion mediated by integrin|negative regulation of cell-matrix adhesion|negative regulation of protein glycosylation in Golgi|positive regulation of cell proliferation|response to retinoic acid|sphingosine biosynthetic process	integral to Golgi membrane	ceramidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	13						AACAACATCTCTCTGATGACC	0.547000													7	87					0	0	1	0	0
CPXCR1	53336	broad.mit.edu	37	X	88009103	88009103	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:88009103C>T	ENST00000276127.4	+	3	947	c.688C>T	c.(688-690)Cgt>Tgt	p.R230C	CPXCR1_ENST00000373111.1_Missense_Mutation_p.R230C	NM_033048.5	NP_149037.4	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	230						intracellular	zinc ion binding	p.R230C(1)		NS(1)|cervix(1)|kidney(1)|large_intestine(11)|liver(1)|lung(20)|ovary(3)|upper_aerodigestive_tract(2)	40						ATGTAGATTCCGTGCTATTGT	0.378000													7	12					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476640	120476640	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr9:120476640G>C	ENST00000355622.6	+	3	2335	c.2234G>C	c.(2233-2235)cGc>cCc	p.R745P	TLR4_ENST00000394487.4_Missense_Mutation_p.R705P|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	745	TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						ATCCAGAGCCGCTGGTGTATC	0.488000													4	48					0	0	1	0	0
DGKD	8527	broad.mit.edu	37	2	234359637	234359637	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:234359637C>T	ENST00000264057.2	+	17	2120	c.2108C>T	c.(2107-2109)cCg>cTg	p.P703L	DGKD_ENST00000409813.3_Missense_Mutation_p.P659L	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	703					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	GCTTCCCTTCCGCCCCAGCCG	0.592000													7	101					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134072151	134072151	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:134072151G>T	ENST00000264360.4	+	1	1682	c.856G>T	c.(856-858)Gtg>Ttg	p.V286L		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	286	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		CGGTGAGGTCGTGTACTCCTT	0.627000													19	59					5.26018e-13	6.88096e-13	1	1	0
OR4C46	119749	broad.mit.edu	37	11	51515668	51515668	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:51515668C>A	ENST00000328188.1	+	1	387	c.387C>A	c.(385-387)caC>caA	p.H129Q		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						AGCCCTTGCACTATATGACTA	0.488000													24	134					9.57634e-11	1.21857e-10	1	1	0
BEND6	221336	broad.mit.edu	37	6	56880096	56880096	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:56880096C>G	ENST00000370746.3	+	4	733	c.464C>G	c.(463-465)tCc>tGc	p.S155C	BEND6_ENST00000545789.1_Missense_Mutation_p.S57C|BEND6_ENST00000370750.2_3'UTR|BEND6_ENST00000484701.1_3'UTR	NM_152731.2	NP_689944.2	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	155										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	17						AATTCTAACTCCAGTTCACCA	0.438000													6	116					0	0	1	0	0
MAMLD1	10046	broad.mit.edu	37	X	149638282	149638282	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:149638282T>A	ENST00000370401.2	+	4	747	c.437T>A	c.(436-438)gTa>gAa	p.V146E	MAMLD1_ENST00000262858.5_Missense_Mutation_p.V146E|MAMLD1_ENST00000432680.2_Missense_Mutation_p.V121E|MAMLD1_ENST00000468306.1_3'UTR|MAMLD1_ENST00000426613.2_Missense_Mutation_p.V121E			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	146					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					TCACCATTTGTAGTACCACAG	0.498000													7	48					0	0	1	0	0
HIST1H1B	3009	broad.mit.edu	37	6	27835082	27835082	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:27835082C>T	ENST00000331442.3	-	1	277	c.226G>A	c.(226-228)Gtg>Atg	p.V76M		NM_005322.2	NP_005313.1	P16401	H15_HUMAN	histone cluster 1, H1b	76	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(12)|prostate(2)|upper_aerodigestive_tract(2)	24						TTCTTCTCCACGTCGTAGCCA	0.562000													12	201					0	0	1	0	0
GRIA4	2893	broad.mit.edu	37	11	105797466	105797466	+	Splice_Site	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:105797466G>T	ENST00000393127.2	+	13	2293		c.e13-1		GRIA4_ENST00000530497.1_Splice_Site|GRIA4_ENST00000282499.5_Splice_Site|GRIA4_ENST00000525187.1_Splice_Site	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4						glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	tccatgtttagaTCCCTCTCA	0.353000													14	55					3.27435e-08	3.8712e-08	1	1	0
FCGBP	8857	broad.mit.edu	37	19	40366284	40366284	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:40366284G>A	ENST00000221347.6	-	30	13957	c.13950C>T	c.(13948-13950)tgC>tgT	p.C4650C		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4650	VWFD 11.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			ACGGCGACGGGCATGGCTTGG	0.736000													7	54					0	0	1	0	0
SGCB	6443	broad.mit.edu	37	4	52894225	52894225	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:52894225T>A	ENST00000381431.5	-	5	884	c.662A>T	c.(661-663)gAt>gTt	p.D221V	SGCB_ENST00000535450.1_Missense_Mutation_p.D151V	NM_000232.4	NP_000223.1	Q16585	SGCB_HUMAN	sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)	221	Cys-rich.				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma				breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(6)|prostate(1)	17			GBM - Glioblastoma multiforme(4;7.63e-12)|LUSC - Lung squamous cell carcinoma(32;0.00204)			AGCACGCCCATCAACTTTTAT	0.333000													12	46					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50705365	50705365	+	Silent	SNP	C	C	A	rs151062007		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr18:50705365C>A	ENST00000442544.2	+	9	2068	c.1452C>A	c.(1450-1452)tcC>tcA	p.S484S	DCC_ENST00000412726.1_Silent_p.S332S|DCC_ENST00000581580.1_Silent_p.S139S	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	484	Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane		p.S484S(1)		NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGCCTGGGTCCCTTCAGCTCA	0.453000													5	37					0.014758	0.0152141	1	1	0
FAM114A2	10827	broad.mit.edu	37	5	153381906	153381906	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:153381906G>A	ENST00000351797.4	-	11	1237	c.1161C>T	c.(1159-1161)gcC>gcT	p.A387A	FAM114A2_ENST00000522858.1_Silent_p.A387A|FAM114A2_ENST00000520667.1_Silent_p.A387A|FAM114A2_ENST00000520313.1_Silent_p.A317A	NM_018691.2	NP_061161.2	Q9NRY5	F1142_HUMAN	family with sequence similarity 114, member A2	387							purine nucleotide binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)|urinary_tract(1)	18						CAATTGAGCAGGCAGTCAGTT	0.448000													10	67					0	0	1	0	0
HPX	3263	broad.mit.edu	37	11	6453034	6453034	+	Splice_Site	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:6453034C>A	ENST00000265983.3	-	9	1067		c.e9-1			NM_000613.2	NP_000604.1	P02790	HEMO_HUMAN	hemopexin						cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding			endometrium(1)|large_intestine(2)|lung(11)|prostate(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		CCTGGGTGCCCTGGAGGACAA	0.502000													9	147					3.86212e-05	4.2538e-05	1	1	0
SLC8A1	6546	broad.mit.edu	37	2	40366544	40366544	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:40366544G>C	ENST00000406785.1	-	7	2623	c.2434C>G	c.(2434-2436)Cca>Gca	p.P812A	SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1_ENST00000405901.3_Missense_Mutation_p.P843A|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1_ENST00000405269.1_Missense_Mutation_p.P812A|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1_ENST00000406391.2_Missense_Mutation_p.P812A|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1_ENST00000542756.1_Missense_Mutation_p.P843A|SLC8A1_ENST00000542024.1_Missense_Mutation_p.P812A|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1_ENST00000403092.1_Missense_Mutation_p.P848A|SLC8A1_ENST00000408028.2_Missense_Mutation_p.P840A|SLC8A1_ENST00000402441.1_Missense_Mutation_p.P812A|SLC8A1_ENST00000332839.4_Missense_Mutation_p.P848A			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	848					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TTTGTACCTGGCACTGATGTT	0.448000													18	15					0	0	1	0	0
IGHV1-58	28464	broad.mit.edu	37	14	107078510	107078510	+	RNA	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:107078510C>T	ENST00000390628.2	-	0	274																											CCACTGCCAACGACGATCCAT	0.532000													29	92					0	0	1	0	0
FAM13A	10144	broad.mit.edu	37	4	89668138	89668138	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:89668138T>A	ENST00000264344.5	-	19	2618	c.2411A>T	c.(2410-2412)gAg>gTg	p.E804V	FAM13A_ENST00000395002.2_Missense_Mutation_p.E478V|FAM13A_ENST00000513837.1_Missense_Mutation_p.E450V|FAM13A_ENST00000511976.1_Missense_Mutation_p.E390V|FAM13A_ENST00000508369.1_Missense_Mutation_p.E478V|FAM13A_ENST00000503556.1_Missense_Mutation_p.E464V	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	804					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						AGCCACTTTCTCATTAGCAAT	0.378000													10	35					0	0	1	0	0
TEFM	79736	broad.mit.edu	37	17	29227570	29227570	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr17:29227570C>G	ENST00000580840.1	-	3	542	c.506G>C	c.(505-507)aGt>aCt	p.S169T	TEFM_ENST00000581216.1_Missense_Mutation_p.S169T			Q96QE5	TEFM_HUMAN	transcription elongation factor, mitochondrial	169					oxidative phosphorylation|regulation of transcription, DNA-dependent|transcription from mitochondrial promoter	mitochondrial nucleoid|ribonucleoprotein complex	DNA polymerase processivity factor activity|nucleic acid binding|protein binding										AGATATGATACTATTAACTGC	0.398000													11	104					0	0	1	0	0
LRFN4	78999	broad.mit.edu	37	11	66626438	66626438	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:66626438C>A	ENST00000309602.4	+	1	1466	c.1223C>A	c.(1222-1224)gCc>gAc	p.A408D	PC_ENST00000393955.2_Intron|LRFN4_ENST00000393952.3_Intron|PC_ENST00000393960.1_Intron|PC_ENST00000393958.2_Intron	NM_024036.4	NP_076941.2	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III domain containing 4	408	Fibronectin type-III.					integral to membrane				breast(1)|lung(1)|prostate(1)	3						TCTGAGCCAGCCGTGCAGGTG	0.706000													11	33					3.86212e-05	4.2538e-05	1	1	0
DUSP6	1848	broad.mit.edu	37	12	89744505	89744505	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:89744505A>T	ENST00000279488.7	-	2	1929	c.698T>A	c.(697-699)aTc>aAc	p.I233N	DUSP6_ENST00000308385.6_Intron|DUSP6_ENST00000547140.1_5'UTR|DUSP6_ENST00000547291.1_Missense_Mutation_p.I108N	NM_001946.2	NP_001937.2	Q16828	DUS6_HUMAN	dual specificity phosphatase 6	233	Tyrosine-protein phosphatase.				dorsal/ventral pattern formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|nerve growth factor receptor signaling pathway|positive regulation of apoptosis|regulation of endodermal cell fate specification|regulation of fibroblast growth factor receptor signaling pathway|regulation of heart growth|response to nitrosative stress|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(5)|lung(8)|skin(2)|urinary_tract(1)	16						GATGTACTTGATGCCGAATTC	0.502000													47	136					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76660548	76660548	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:76660548G>T	ENST00000369950.3	-	13	1744	c.1555C>A	c.(1555-1557)Cta>Ata	p.L519I	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	519					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				ATTTCATCTAGGTGTCTGACC	0.488000													7	39					8.12818e-05	8.91047e-05	1	1	0
HAT1	8520	broad.mit.edu	37	2	172822973	172822973	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:172822973G>T	ENST00000264108.4	+	7	691	c.655G>T	c.(655-657)Gta>Tta	p.V219L	HAT1_ENST00000392584.1_Missense_Mutation_p.V134L|SLC25A12_ENST00000472748.1_Intron	NM_003642.3	NP_003633.1	O14929	HAT1_HUMAN	histone acetyltransferase 1	219					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			breast(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|prostate(1)	19			OV - Ovarian serous cystadenocarcinoma(117;0.216)			CTTTGCGACCGTAGGCTACAT	0.438000													30	54					6.00712e-18	8.10788e-18	1	1	0
KDM5C	8242	broad.mit.edu	37	X	53222367	53222367	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:53222367C>T	ENST00000375401.3	-	26	4997	c.4465G>A	c.(4465-4467)Gct>Act	p.A1489T	KDM5C_ENST00000404049.3_Missense_Mutation_p.A1488T|KDM5C_ENST00000452825.3_Intron|KDM5C_ENST00000375379.3_Missense_Mutation_p.A1486T|KDM5C_ENST00000375383.3_Missense_Mutation_p.A1445T	NM_004187.3	NP_004178.2	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	1489					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						ACCTCCTCAGCCTCTGGCCCT	0.692000			"""N, F, S"""		clear cell renal carcinoma								22	17					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113536242	113536242	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr13:113536242C>G	ENST00000375630.2	+	29	3528	c.3440C>G	c.(3439-3441)tCt>tGt	p.S1147C	ATP11A_ENST00000375645.3_3'UTR|ATP11A_ENST00000487903.1_3'UTR	NM_032189.3	NP_115565.3	P98196	AT11A_HUMAN	ATPase, class VI, type 11A	0					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				AGCTCCCACTCTCAGCAGGTG	0.642000													4	53					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238250802	238250802	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:238250802G>C	ENST00000295550.4	-	37	8123	c.7671C>G	c.(7669-7671)atC>atG	p.I2557M	COL6A3_ENST00000346358.4_Missense_Mutation_p.I2357M|COL6A3_ENST00000353578.4_Missense_Mutation_p.I2351M|COL6A3_ENST00000347401.3_Missense_Mutation_p.I2356M|COL6A3_ENST00000409809.1_Missense_Mutation_p.I2351M|COL6A3_ENST00000472056.1_Missense_Mutation_p.I1950M	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2557	Nonhelical region.|VWFA 11.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTGTGTTATTGATCTGGTTTA	0.433000													4	23					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46653555	46653555	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr22:46653555G>T	ENST00000253255.5	-	1	5664	c.5665C>A	c.(5665-5667)Cag>Aag	p.Q1889K		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1889					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AACCGCTGCTGTTCTGGAAAA	0.393000													12	75					1.08611e-07	1.27761e-07	1	1	0
ALOX5	240	broad.mit.edu	37	10	45940992	45940992	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:45940992G>C	ENST00000374391.2	+	14	1935	c.1882G>C	c.(1882-1884)Gag>Cag	p.E628Q	RP11-67C2.2_ENST00000435635.1_RNA|ALOX5_ENST00000542434.1_Missense_Mutation_p.E571Q	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	628	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	GCATTTTATCGAGAAGCCTGT	0.527000													10	56					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4869801	4869801	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:4869801G>T	ENST00000322101.2	-	1	713	c.638C>A	c.(637-639)gCc>gAc	p.A213D	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAAACCCATGGCTGAAAGAAC	0.527000													9	85					7.48243e-07	8.73574e-07	1	1	0
ZNF470	388566	broad.mit.edu	37	19	57089781	57089781	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:57089781G>T	ENST00000330619.8	+	6	2670	c.1984G>T	c.(1984-1986)Gcc>Tcc	p.A662S	ZNF470_ENST00000601902.1_Intron|ZNF470_ENST00000391709.3_Missense_Mutation_p.A662S	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	662					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		CAGCCAGGTTGCCCATCTTAC	0.428000													17	63					1.5739e-10	1.98651e-10	1	1	0
TRPV6	55503	broad.mit.edu	37	7	142583200	142583200	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:142583200C>A	ENST00000359396.3	-	1	307	c.62G>T	c.(61-63)aGa>aTa	p.R21I	RP11-114L10.2_ENST00000438839.1_RNA	NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	21					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					CTGGAACCATCTGCAGAACTT	0.612000													19	83					2.5808e-16	3.44352e-16	1	1	0
ZFP42	132625	broad.mit.edu	37	4	188924141	188924141	+	Silent	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:188924141T>A	ENST00000326866.4	+	4	588	c.180T>A	c.(178-180)ccT>ccA	p.P60P	ZFP42_ENST00000509524.1_Silent_p.P60P	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	60					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		AGCCTGGCCCTCAGGCTCTCG	0.522000													5	77					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152080777	152080777	+	Missense_Mutation	SNP	T	T	G	rs71585886		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:152080777T>G	ENST00000368804.1	-	2	4915	c.4916A>C	c.(4915-4917)cAa>cCa	p.Q1639P		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1639	23 X 26 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCACGCTCTTGGCGGTGCAG	0.602000													42	143					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154625341	154625341	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr4:154625341A>C	ENST00000260010.6	+	1	2690	c.1282A>C	c.(1282-1284)Atg>Ctg	p.M428L		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	428					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				TTTTCATTCTATGCCTGAAAC	0.378000													18	52					0	0	1	0	0
SBNO1	55206	broad.mit.edu	37	12	123801892	123801892	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:123801892G>A	ENST00000420886.2	-	20	2810	c.2811C>T	c.(2809-2811)atC>atT	p.I937I	SBNO1_ENST00000267176.4_Silent_p.I936I|SBNO1_ENST00000602750.1_Silent_p.I936I|SBNO1_ENST00000602398.1_Silent_p.I937I	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	937							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CTTCTGAGATGATAGCAATAT	0.393000													5	50					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	2022235	2022235	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:2022235G>A	ENST00000382722.5	-	3	742	c.380C>T	c.(379-381)tCa>tTa	p.S127L	CACNA2D4_ENST00000585732.1_Missense_Mutation_p.S127L|CACNA2D4_ENST00000585708.1_Missense_Mutation_p.S63L|CACNA2D4_ENST00000586184.1_Missense_Mutation_p.S127L|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.S127L|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.S63L	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	127						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CATGTCCTCTGAGAACTTCCT	0.572000													11	27					0	0	1	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973670	46973670	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:46973670G>C	ENST00000313683.10	-	2	928	c.623C>G	c.(622-624)tCt>tGt	p.S208C	PNMAL1_ENST00000438932.2_Missense_Mutation_p.S208C|PNMAL1_ENST00000602246.1_Intron	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	208										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CTTTAAGGCAGAACCCACCTC	0.587000													6	91					0	0	1	0	0
PRKG1	5592	broad.mit.edu	37	10	53227522	53227522	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:53227522G>T	ENST00000373980.4	+	3	935	c.518G>T	c.(517-519)tGt>tTt	p.C173F	PRKG1_ENST00000373985.1_Missense_Mutation_p.C146F|PRKG1_ENST00000401604.2_Missense_Mutation_p.C158F	NM_006258.3	NP_006249.1	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I	158					actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	53		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		GTGAAGTTGTGTACCATGGGT	0.363000													4	54					0.0293803	0.0298924	1	1	0
HAUS5	23354	broad.mit.edu	37	19	36109870	36109870	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:36109870G>A	ENST00000203166.5	+	13	1123	c.1098G>A	c.(1096-1098)caG>caA	p.Q366Q	HAUS5_ENST00000379045.2_3'UTR	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	366					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						AGGAGCTGCAGGATGCAGCTG	0.652000													6	41					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70963564	70963564	+	Silent	SNP	G	G	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:70963564G>A	ENST00000334414.6	-	14	3569	c.3525C>T	c.(3523-3525)caC>caT	p.H1175H	PTPRB_ENST00000550857.1_Silent_p.H867H|PTPRB_ENST00000261266.5_Silent_p.H957H|PTPRB_ENST00000551525.1_Silent_p.H1174H|PTPRB_ENST00000550358.1_Silent_p.H1087H|PTPRB_ENST00000451516.2_Silent_p.H867H|PTPRB_ENST00000538708.1_Silent_p.H957H	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	957	Fibronectin type-III 14.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GCTCAAAGACGTGCTTGGGAA	0.532000													6	68					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141754683	141754683	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:141754683C>T	ENST00000475668.2	+	27	3343	c.3289C>T	c.(3289-3291)Cgc>Tgc	p.R1097C	MGAM_ENST00000549489.2_Missense_Mutation_p.R1097C			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1097	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity	p.R1097C(2)		cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GATTGAAATTCGCCGGAAGAG	0.498000													11	77					0	0	1	0	0
KAT6B	23522	broad.mit.edu	37	10	76603121	76603121	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:76603121G>T	ENST00000287239.4	+	3	995	c.506G>T	c.(505-507)gGa>gTa	p.G169V	KAT6B_ENST00000372711.1_Missense_Mutation_p.G169V|KAT6B_ENST00000372724.1_Missense_Mutation_p.G169V|KAT6B_ENST00000372714.1_Missense_Mutation_p.G169V|KAT6B_ENST00000372725.1_Missense_Mutation_p.G169V	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	169	H15.				histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										CTGAAAGACGGACCGCAGTAC	0.557000													7	56					0.00198382	0.00209129	1	1	0
EPHA3	2042	broad.mit.edu	37	3	89390966	89390966	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:89390966C>A	ENST00000336596.2	+	5	1257	c.1032C>A	c.(1030-1032)gaC>gaA	p.D344E	EPHA3_ENST00000494014.1_Missense_Mutation_p.D344E|EPHA3_ENST00000452448.2_Missense_Mutation_p.D344E	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	344	Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TTATCCTGGACTGGAGTTGGC	0.433000										TSP Lung(6;0.00050)			30	41					1.30897e-18	1.77701e-18	1	1	0
GTDC1	79712	broad.mit.edu	37	2	144903231	144903231	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:144903231C>G	ENST00000409214.1	-	5	533	c.255G>C	c.(253-255)aaG>aaC	p.K85N	GTDC1_ENST00000344850.4_Missense_Mutation_p.K85N|GTDC1_ENST00000392869.1_Missense_Mutation_p.K85N|GTDC1_ENST00000542155.1_Missense_Mutation_p.K85N|GTDC1_ENST00000392867.3_Missense_Mutation_p.K85N|GTDC1_ENST00000241391.5_Missense_Mutation_p.K85N|GTDC1_ENST00000463875.2_5'UTR|GTDC1_ENST00000409298.1_Missense_Mutation_p.K85N	NM_001006636.3	NP_001006637.1	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	85					biosynthetic process		transferase activity, transferring glycosyl groups			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(17)|ovary(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.0914)		AATACAGAATCTTTTTCAGTT	0.423000													6	79					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121151780	121151780	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr3:121151780T>A	ENST00000264233.5	-	29	7772	c.7644A>T	c.(7642-7644)gaA>gaT	p.E2548D		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	2548					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		CAACATCTTCTTCTGCCACTT	0.443000								DNA polymerases (catalytic subunits)					24	22					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73039801	73039801	+	Splice_Site	SNP	C	C	T	rs146776724		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:73039801C>T	ENST00000335350.6	+	2	719	c.304_splice	c.e2+1	p.T101_splice	UNC5B_ENST00000373192.4_Splice_Site_p.T101_splice	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	101	Ig-like.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						ATGAGGCCACCGGTGAGCCCG	0.652000													6	49					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46884215	46884215	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:46884215A>T	ENST00000378623.1	-	37	5569	c.5327T>A	c.(5326-5328)gTg>gAg	p.V1776E	LRP4-AS1_ENST00000531719.1_RNA|LRP4-AS1_ENST00000502049.2_RNA	NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	1776					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		TTCAATCTTCACTTCCTGTGT	0.443000													37	92					0	0	1	0	0
MRPL14	64928	broad.mit.edu	37	6	44081947	44081947	+	Splice_Site	SNP	C	C	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:44081947C>T	ENST00000372014.3	-	3	203		c.e3-1			NM_032111.2	NP_115487.2	Q6P1L8	RM14_HUMAN	mitochondrial ribosomal protein L14						translation	mitochondrion|ribosome	structural constituent of ribosome			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	12	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0181)			CCCAGTGGTGCTGGTGGGAGG	0.547000													12	192					0	0	1	0	0
SLC12A6	9990	broad.mit.edu	37	15	34628689	34628689	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr15:34628689C>G	ENST00000354181.3	-	2	685	c.193G>C	c.(193-195)Ggg>Cgg	p.G65R	SLC12A6_ENST00000560611.1_Missense_Mutation_p.G65R|SLC12A6_ENST00000397702.2_Missense_Mutation_p.G6R|SLC12A6_ENST00000397707.2_Missense_Mutation_p.G65R|SLC12A6_ENST00000558667.1_Missense_Mutation_p.G65R|SLC12A6_ENST00000458406.2_Missense_Mutation_p.G6R|SLC12A6_ENST00000558589.1_Missense_Mutation_p.G56R			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	65					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	GTGGTGGCCCCAGACATCTCA	0.562000													4	39					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53200974	53200974	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr12:53200974C>G	ENST00000551956.1	-	9	1934	c.1442G>C	c.(1441-1443)gGg>gCg	p.G481A	KRT4_ENST00000458244.2_Missense_Mutation_p.G461A|KRT4_ENST00000293774.4_Missense_Mutation_p.G555A			B4DRS2	B4DRS2_HUMAN	keratin 4	481						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						CAGGCCAAACCCGGAGCCACT	0.547000													16	71					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156590266	156590266	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr5:156590266G>T	ENST00000302938.4	-	2	1105	c.1010C>A	c.(1009-1011)tCc>tAc	p.S337Y		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	337						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACCCTCTGAGGATATGTTGGC	0.577000													18	73					5.3912e-06	6.17081e-06	1	1	0
PANK1	53354	broad.mit.edu	37	10	91404901	91404901	+	Silent	SNP	G	G	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr10:91404901G>T	ENST00000307534.4	-	1	314	c.159C>A	c.(157-159)ccC>ccA	p.P53P		NM_148977.2	NP_683878.1	Q8TE04	PANK1_HUMAN	pantothenate kinase 1	53					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity			cervix(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)	11					Bezafibrate(DB01393)	GCGCGGAATCGGGGATCCCCG	0.791000													3	6					0.004672	0.00487014	1	1	0
LGMN	5641	broad.mit.edu	37	14	93199070	93199070	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr14:93199070T>C	ENST00000393218.2	-	3	399	c.62A>G	c.(61-63)gAt>gGt	p.D21G	LGMN_ENST00000334869.4_Missense_Mutation_p.D21G|LGMN_ENST00000555699.1_Missense_Mutation_p.D21G|LGMN_ENST00000557434.1_Missense_Mutation_p.D21G	NM_001008530.2	NP_001008530.1	Q99538	LGMN_HUMAN	legumain	21					hormone biosynthetic process|negative regulation of neuron apoptosis|vitamin D metabolic process	lysosome	cysteine-type endopeptidase activity|protein serine/threonine kinase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|skin(2)	18		all_cancers(154;0.0706)		COAD - Colon adenocarcinoma(157;0.224)		TTCAGGATCATCTATAGGAAC	0.468000													18	103					0	0	1	0	0
GPN1	11321	broad.mit.edu	37	2	27851919	27851919	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr2:27851919G>C	ENST00000264718.3	+	1	57	c.36G>C	c.(34-36)agG>agC	p.R12S	GPN1_ENST00000515877.1_Intron|GPN1_ENST00000458167.2_Intron|ZNF512_ENST00000556601.1_Intron|RP11-158I13.2_ENST00000505973.1_RNA|GPN1_ENST00000407583.3_Intron|GPN1_ENST00000503738.1_Intron|GPN1_ENST00000424214.1_Intron	NM_007266.3	NP_009197.2	Q9HCN4	GPN1_HUMAN	GPN-loop GTPase 1	0						cytoplasm	GTP binding|nucleoside-triphosphatase activity|protein binding			endometrium(1)|large_intestine(1)|lung(12)	14						GTGGGGCCAGGAGGAAGATGG	0.627000													4	74					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55134612	55134613	+	Splice_Site	INS	-	-	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:55134612_55134613insG	ENST00000414150.2	+	5	1667		c.e5+2		MROH7_ENST00000421030.2_Splice_Site|MROH7_ENST00000339553.5_Splice_Site|MROH7_ENST00000545244.1_Splice_Site|MROH7_ENST00000409996.1_Splice_Site|MROH7_ENST00000454855.2_Splice_Site|MROH7_ENST00000395690.2_Splice_Site					maestro heat-like repeat family member 7																		AAGATTATGGTGGGGGAGCCAC	0.559													8	45	---	---	---	---					
LPHN2	23266	broad.mit.edu	37	1	82436124	82436124	+	Frame_Shift_Del	DEL	A	A	-			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:82436124delA	ENST00000370728.1	+	18	3493	c.2848delA	c.(2848-2850)aafs	p.K951fs	LPHN2_ENST00000370713.1_Frame_Shift_Del_p.K938fs|LPHN2_ENST00000370730.1_Frame_Shift_Del_p.K951fs|LPHN2_ENST00000359929.3_Frame_Shift_Del_p.K938fs|LPHN2_ENST00000370715.1_Frame_Shift_Del_p.K938fs|LPHN2_ENST00000335786.5_Frame_Shift_Del_p.K951fs|LPHN2_ENST00000394879.1_Frame_Shift_Del_p.K938fs|LPHN2_ENST00000370725.1_Frame_Shift_Del_p.K951fs|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000319517.6_Frame_Shift_Del_p.K938fs|LPHN2_ENST00000271029.4_Frame_Shift_Del_p.K951fs|LPHN2_ENST00000370717.2_Frame_Shift_Del_p.K951fs|LPHN2_ENST00000370721.1_Frame_Shift_Del_p.K876fs|LPHN2_ENST00000370723.1_Frame_Shift_Del_p.K938fs|LPHN2_ENST00000370727.1_Frame_Shift_Del_p.K951fs			O95490	LPHN2_HUMAN	latrophilin 2	951					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ATATTCAAGGAAAAAATATTA	0.378													7	87	---	---	---	---					
FMN2	56776	broad.mit.edu	37	1	240255569	240255571	+	In_Frame_Del	DEL	GGC	GGC	-	rs71929261		TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr1:240255569_240255571delGGC	ENST00000319653.9	+	1	390_392	c.160_162delGGC	c.(160-162)del	p.G59del		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	59					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.G197delG(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGGGGGAgggggcggcggcggcg	0.665													2	4	---	---	---	---					
DNAH8	1769	broad.mit.edu	37	6	38917244	38917245	+	Frame_Shift_Ins	INS	-	-	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr6:38917244_38917245insT	ENST00000359357.3	+	79	11749_11750	c.11495_11496insT	c.(11494-11496)aggfs	p.R3832fs	DNAH8_ENST00000441566.1_Frame_Shift_Ins_p.R3796fs|DNAH8_ENST00000449981.2_Frame_Shift_Ins_p.R4049fs|RP1-207H1.3_ENST00000416948.1_RNA					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CGTAATGAGAAGGGGTGGAAAA	0.376													7	157	---	---	---	---					
ADAP1	11033	broad.mit.edu	37	7	944739	944740	+	Frame_Shift_Ins	INS	-	-	A			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr7:944739_944740insA	ENST00000265846.5	-	5	677_678	c.458_459insT	c.(457-459)cacfs	p.H153fs	ADAP1_ENST00000539900.1_Frame_Shift_Ins_p.H164fs|ADAP1_ENST00000463358.1_5'UTR|ADAP1_ENST00000449296.2_Frame_Shift_Ins_p.H81fs	NM_006869.2	NP_006860.1	O75689	ADAP1_HUMAN	ArfGAP with dual PH domains 1	153	PH 1.				cell surface receptor linked signaling pathway|regulation of ARF GTPase activity	cytoplasm|nucleus|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|lung(3)|upper_aerodigestive_tract(1)	6						CTCGTTCTGTCAGCACAAACTT	0.604													24	23	---	---	---	---					
LOC101929268	101929268	broad.mit.edu	37	8	49559996	49559996	+	RNA	DEL	G	G	-			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr8:49559996delG	ENST00000522575.1	+	0	356																											ATGGAGCCAAGGAAGTGTGGA	0.582													2	4	---	---	---	---					
OR51D1	390038	broad.mit.edu	37	11	4661484	4661484	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:4661484delC	ENST00000357605.2	+	1	540	c.464delC	c.(463-465)gcfs	p.A155fs		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTACTGTGGCCAAGATTGGA	0.542													41	110	---	---	---	---					
OR4A15	81328	broad.mit.edu	37	11	55135687	55135688	+	Frame_Shift_Ins	INS	-	-	T			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr11:55135687_55135688insT	ENST00000314706.3	+	1	328_329	c.328_329insT	c.(328-330)tgtfs	p.C110fs		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						TCCCAAAATGATTGTTGACTTG	0.416													35	159	---	---	---	---					
GABRB3	2562	broad.mit.edu	37	15	27184517	27184518	+	Frame_Shift_Ins	INS	-	-	A	rs17647384	by1000genomes	TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr15:27184517_27184518insA	ENST00000541819.2	-	1	168_169	c.66_67insT	c.(64-69)tggcctfs	p.WP22fs	GABRA5_ENST00000355395.5_Intron|GABRA5_ENST00000400081.3_Intron|GABRA5_ENST00000335625.5_Intron			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	0					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AAGAACAGGCGACACCTCTCTG	0.594													8	40	---	---	---	---					
PHKB	5257	broad.mit.edu	37	16	47684775	47684775	+	Frame_Shift_Del	DEL	G	G	-			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr16:47684775delG	ENST00000455779.1	+	21	2078	c.1893delG	c.(1891-1893)ctfs	p.L631fs	PHKB_ENST00000323584.5_Frame_Shift_Del_p.L638fs|PHKB_ENST00000566044.1_Frame_Shift_Del_p.L631fs|PHKB_ENST00000299167.8_Frame_Shift_Del_p.L638fs			Q93100	KPBB_HUMAN	phosphorylase kinase, beta	638					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|liver(1)|lung(18)|ovary(1)|skin(1)	41		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				TAGATATGCTGGCAGCCCTTA	0.338													31	52	---	---	---	---					
PDP2	57546	broad.mit.edu	37	16	66919531	66919531	+	Frame_Shift_Del	DEL	G	G	-			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr16:66919531delG	ENST00000311765.2	+	2	1678	c.1344delG	c.(1342-1344)ttfs	p.L448fs	PDP2_ENST00000568720.1_Intron	NM_020786.2	NP_065837.1	Q9P2J9	PDP2_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 2	448					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		CCGCCAACTTGGGGCTCATGC	0.617													25	40	---	---	---	---					
ANGPTL6	83854	broad.mit.edu	37	19	10206840	10206841	+	Frame_Shift_Ins	INS	-	-	G			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:10206840_10206841insG	ENST00000253109.4	-	2	637_638	c.399_400insC	c.(397-402)gccggcfs	p.G134fs	ANGPTL6_ENST00000589181.1_Frame_Shift_Ins_p.G134fs|ANGPTL6_ENST00000592641.1_Frame_Shift_Ins_p.G134fs	NM_031917.2	NP_114123.2	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6	134					angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)	12			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			GCCAGCGCCGCGGCAGGCTCCG	0.792													5	2	---	---	---	---					
ZNF677	342926	broad.mit.edu	37	19	53740671	53740672	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr19:53740671_53740672delCA	ENST00000333952.4	-	5	1473_1474	c.1308_1309delTG	c.(1306-1311)tggcfs	p.CG436fs	ZNF677_ENST00000598513.1_Frame_Shift_Del_p.CG436fs			Q86XU0	ZN677_HUMAN	zinc finger protein 677	436					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		AAAGCCCTGCCACACACATTAC	0.371													7	37	---	---	---	---					
SLC12A5	57468	broad.mit.edu	37	20	44685942	44685943	+	Splice_Site	DEL	TG	TG	-			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chr20:44685942_44685943delTG	ENST00000454036.1	+	25	3404	c.3328_splice	c.e25+1	p.1110_splice	SLC12A5_ENST00000243964.3_Splice_Site_p.1087_splice	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	1110					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGATGAAAACTGTATCCTGGAA	0.559													10	134	---	---	---	---					
SSX3	10214	broad.mit.edu	37	X	48209460	48209460	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MP-A4SV-01A-11D-A24P-08	TCGA-MP-A4SV-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f64488c5-16e2-402f-aead-720962f06907	e3dcb110-bb8a-4483-9894-25cff1fd6de5	g.chrX:48209460delC	ENST00000298396.2	-	6	480	c.428delG	c.(427-429)gafs	p.G143fs	SSX3_ENST00000376895.1_Frame_Shift_Del_p.G55fs|SSX3_ENST00000376893.3_Frame_Shift_Del_p.G143fs	NM_021014.2	NP_066294.1	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3	143					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			endometrium(3)|large_intestine(1)|lung(9)	13						AGTTGGTTTTCCCGGGGGGCA	0.502													124	77	---	---	---	---