Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PAX7	5081	broad.mit.edu	37	1	19062344	19062344	+	Silent	SNP	C	C	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:19062344C>A	ENST00000420770.2	+	8	1457	c.1374C>A	c.(1372-1374)gcC>gcA	p.A458A	PAX7_ENST00000400661.3_Silent_p.A456A|PAX7_ENST00000375375.3_Silent_p.A458A	NM_001135254.1	NP_001128726.1	P23759	PAX7_HUMAN	paired box 7	458					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.A458A(1)	PAX7/FOXO1(197)	breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)	31		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		ACCCCGTGGCCGGCTATCAGT	0.672000			T	FOXO1A	alveolar rhabdomyosarcoma								30	36					1.08312e-15	1.32005e-15	1	1	0
SETDB1	9869	broad.mit.edu	37	1	150923335	150923335	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:150923335A>T	ENST00000271640.5	+	13	2172	c.1982A>T	c.(1981-1983)gAt>gTt	p.D661V	SETDB1_ENST00000368969.4_Missense_Mutation_p.D661V|SETDB1_ENST00000459773.1_Intron	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	661	MBD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			TTCTGTTTGGATCCATATGTT	0.453000													15	75					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	132021539	132021539	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr2:132021539G>T	ENST00000356920.5	+	15	2605	c.2511G>T	c.(2509-2511)caG>caT	p.Q837H	PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron|POTEE_ENST00000358087.5_3'UTR	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	837	Actin-like.						ATP binding										TGGCCATCCAGGCCGTGCCGT	0.607000													33	234					6.97489e-18	8.59012e-18	1	1	0
MUC4	4585	broad.mit.edu	37	3	195505814	195505814	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr3:195505814C>T	ENST00000463781.3	-	2	13096	c.12637G>A	c.(12637-12639)Gac>Aac	p.D4213N	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.D4213N|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	970					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.D4213N(1)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGAAGTGTCGGTGACAGGA	0.597000													3	7					0	0	1	0	0
FOXJ2	55810	broad.mit.edu	37	12	8196336	8196336	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr12:8196336C>T	ENST00000162391.3	+	4	1593	c.448C>T	c.(448-450)Cga>Tga	p.R150*	FOXJ2_ENST00000428177.2_Nonsense_Mutation_p.R150*	NM_018416.2	NP_060886.1	Q9P0K8	FOXJ2_HUMAN	forkhead box J2	150					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	nucleolus|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding	p.R150R(1)		autonomic_ganglia(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	16				Kidney(36;0.0944)		TGACATTTCCCGAAAGAGAAG	0.483000													64	122					0	0	1	0	0
PNPT1	87178	broad.mit.edu	37	2	55867787	55867787	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr2:55867787T>C	ENST00000447944.2	-	26	2209	c.2123A>G	c.(2122-2124)cAt>cGt	p.H708R		NM_033109.3	NP_149100.2	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	708	S1 motif.				mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			TTGTGTGTTATGAAGCAGTAC	0.299000													18	42					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													7	61					0	0	1	0	0
SETDB1	9869	broad.mit.edu	37	1	150923334	150923334	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:150923334G>T	ENST00000271640.5	+	13	2171	c.1981G>T	c.(1981-1983)Gat>Tat	p.D661Y	SETDB1_ENST00000368969.4_Missense_Mutation_p.D661Y|SETDB1_ENST00000459773.1_Intron	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	661	MBD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GTTCTGTTTGGATCCATATGT	0.448000													15	73					3.27435e-08	3.83099e-08	1	1	0
SPEM1	374768	broad.mit.edu	37	17	7324312	7324312	+	Silent	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr17:7324312G>A	ENST00000323675.3	+	3	343	c.318G>A	c.(316-318)ccG>ccA	p.P106P	RP11-104H15.7_ENST00000575310.1_RNA	NM_199339.2	NP_955371.2	Q8N4L4	SPEM1_HUMAN	spermatid maturation 1	106					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|integral to membrane				endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	12		Prostate(122;0.173)				CTGTGTCCCCGCCCCCAGCTC	0.587000													31	37					0	0	1	0	0
LRIT3	345193	broad.mit.edu	37	4	110788911	110788911	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr4:110788911C>G	ENST00000327908.3	+	3	919	c.155C>G	c.(154-156)cCt>cGt	p.P52R	LRIT3_ENST00000409621.2_Missense_Mutation_p.P52R|LRIT3_ENST00000379920.3_Missense_Mutation_p.P190R|LRIT3_ENST00000594814.1_Missense_Mutation_p.P235R			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	190						integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		TGCAGTGAACCTGAGCGCCTC	0.473000													13	70					0	0	1	0	0
PSMC5	5705	broad.mit.edu	37	17	61907817	61907817	+	Nonsense_Mutation	SNP	A	A	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr17:61907817A>T	ENST00000310144.6	+	6	816	c.508A>T	c.(508-510)Aag>Tag	p.K170*	PSMC5_ENST00000375812.4_Nonsense_Mutation_p.K162*|PSMC5_ENST00000580864.1_Nonsense_Mutation_p.K162*|PSMC5_ENST00000581882.1_Nonsense_Mutation_p.K162*	NM_002805.5	NP_002796.4	P62195	PRS8_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 5	170					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of programmed cell death|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus|proteasome complex	ATP binding|ATPase activity|thyrotropin-releasing hormone receptor binding|transcription cofactor activity|transcription factor binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	20						GCTGCCTGTTAAGCATCCTGA	0.507000													20	42					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37903017	37903017	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr7:37903017T>C	ENST00000199447.4	+	8	779	c.407T>C	c.(406-408)gTa>gCa	p.V136A	NME8_ENST00000440017.1_Missense_Mutation_p.V136A|EPDR1_ENST00000476620.1_Intron	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	136					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										ATTCCATTAGTAGACTCAGAT	0.333000													9	119					0	0	1	0	0
RNF19A	25897	broad.mit.edu	37	8	101287227	101287227	+	Silent	SNP	A	A	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr8:101287227A>G	ENST00000519449.1	-	4	1153	c.837T>C	c.(835-837)acT>acC	p.T279T	RNF19A_ENST00000341084.2_Silent_p.T279T	NM_015435.3	NP_056250.3	Q9NV58	RN19A_HUMAN	ring finger protein 19A, RBR E3 ubiquitin protein ligase	279					microtubule cytoskeleton organization|protein modification process	centrosome|integral to membrane	ligase activity|transcription factor binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	30	all_cancers(14;3.5e-05)|all_epithelial(15;8.91e-08)|Lung NSC(17;0.000615)|all_lung(17;0.00166)		Epithelial(11;3.06e-11)|all cancers(13;5.78e-09)|OV - Ovarian serous cystadenocarcinoma(57;2.24e-05)|STAD - Stomach adenocarcinoma(118;0.0525)			AAGAACGTATAGTTCTCAAAC	0.393000													9	54					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156642197	156642197	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:156642197C>T	ENST00000368223.3	-	4	1915	c.1783G>A	c.(1783-1785)Gag>Aag	p.E595K		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	595	Tail.			ELLKDVEVVRPLEKEAVG -> RAIKGCGGSETSRKRGCR (in Ref. 1; CAA46780).	brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TTTAATAGCTCTTTATTTTCC	0.408000													14	71					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47422511	47422511	+	Silent	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr19:47422511G>A	ENST00000404338.3	+	1	579	c.579G>A	c.(577-579)aaG>aaA	p.K193K		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	193					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										AAACAAAAAAGCCCATAGTGG	0.428000													9	41					0	0	1	0	0
OTOP1	133060	broad.mit.edu	37	4	4199064	4199064	+	Silent	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr4:4199064G>T	ENST00000296358.4	-	5	1521	c.1497C>A	c.(1495-1497)gcC>gcA	p.A499A		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	499					biomineral tissue development	extracellular space|integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CATTTCCATTGGCTGCTGGTG	0.597000													22	88					1.9806e-07	2.29436e-07	1	1	0
TRIM22	10346	broad.mit.edu	37	11	5730866	5730866	+	Silent	SNP	A	A	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr11:5730866A>G	ENST00000379965.3	+	8	1762	c.1485A>G	c.(1483-1485)ccA>ccG	p.P495P	TRIM5_ENST00000380027.1_Intron	NM_001199573.1|NM_006074.4	NP_001186502.1|NP_006065.2	Q8IYM9	TRI22_HUMAN	tripartite motif containing 22	495	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			kidney(3)|large_intestine(8)|lung(9)|prostate(1)|stomach(2)	23		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		CTGTGTGCCCACCGAGCTCCT	0.493000													14	106					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201030409	201030409	+	Silent	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:201030409G>A	ENST00000362061.3	-	25	3467	c.3241C>T	c.(3241-3243)Ctg>Ttg	p.L1081L	CACNA1S_ENST00000367338.3_Silent_p.L1081L	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1081					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TTCTTGTCCAGCTCACAGTTC	0.562000													4	31					0	0	1	0	0
MS4A10	341116	broad.mit.edu	37	11	60565933	60565933	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr11:60565933C>T	ENST00000308287.1	+	7	764	c.668C>T	c.(667-669)cCg>cTg	p.P223L		NM_206893.3	NP_996776.2	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member 10	223						integral to membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|skin(2)	21						GTGGAGCCCCCGCCATCCTAC	0.562000													9	56					0	0	1	0	0
SLC17A9	63910	broad.mit.edu	37	20	61594048	61594048	+	Silent	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr20:61594048C>T	ENST00000370349.3	+	6	756	c.552C>T	c.(550-552)tcC>tcT	p.S184S	SLC17A9_ENST00000370351.4_Silent_p.S190S|SLC17A9_ENST00000488738.1_3'UTR			Q9BYT1	S17A9_HUMAN	solute carrier family 17 (vesicular nucleotide transporter), member 9	190					exocytosis|transmembrane transport	integral to membrane	transporter activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	23						TCTATTTCTCCGGCGGCCTCA	0.637000													13	129					0	0	1	0	0
PSG11	5680	broad.mit.edu	37	19	43523042	43523042	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr19:43523042C>T	ENST00000401740.1	-	3	692	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	PSG11_ENST00000403486.1_Missense_Mutation_p.E75K|PSG11_ENST00000320078.7_Missense_Mutation_p.E197K|PSG11_ENST00000306322.7_Missense_Mutation_p.E75K|PSG11_ENST00000595312.1_5'UTR			Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	197	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	26		Prostate(69;0.00682)				CTGTTGGTTTCAGACAGCTGC	0.498000													28	305					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186045577	186045577	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:186045577A>G	ENST00000271588.4	+	54	8537	c.8308A>G	c.(8308-8310)Aaa>Gaa	p.K2770E	HMCN1_ENST00000367492.2_Missense_Mutation_p.K2770E	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2770	Ig-like C2-type 26.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AAGTTTTCAGAAACTCTGGGA	0.388000													8	43					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664743	22664743	+	RNA	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr22:22664743G>A	ENST00000426066.1	+	0	924					NR_027293.1																						CAGACTAAAGGCAAACAAGGA	0.498000													4	28					0	0	1	0	0
LIN7C	55327	broad.mit.edu	37	11	27520276	27520276	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr11:27520276G>A	ENST00000278193.2	-	5	534	c.514C>T	c.(514-516)Cga>Tga	p.R172*	LIN7C_ENST00000524596.1_Nonsense_Mutation_p.R148*	NM_018362.3	NP_060832.1	Q9NUP9	LIN7C_HUMAN	lin-7 homolog C (C. elegans)	172	PDZ.				exocytosis|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction		p.R172*(1)		endometrium(2)|lung(2)|upper_aerodigestive_tract(1)	5						GGTGTGTATCGTACCACTAAT	0.393000													9	99					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54612423	54612423	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr7:54612423G>T	ENST00000302287.3	+	2	594	c.188G>T	c.(187-189)tGg>tTg	p.W63L	VSTM2A_ENST00000407838.3_Missense_Mutation_p.W63L|VSTM2A_ENST00000404951.1_Missense_Mutation_p.W63L|VSTM2A_ENST00000402026.2_Missense_Mutation_p.W62L|VSTM2A_ENST00000402613.3_Missense_Mutation_p.W63L			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	63	Ig-like V-type.					extracellular region				endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			GAGATCCAATGGTGGTTCCTG	0.711000													6	28					0.217242	0.217242	1	1	0
PALD1	27143	broad.mit.edu	37	10	72307080	72307080	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr10:72307080C>T	ENST00000263563.6	+	18	2408	c.2140C>T	c.(2140-2142)Cag>Tag	p.Q714*		NM_014431.2	NP_055246.2			phosphatase domain containing, paladin 1																		GAAGGTGGTGCAGCTGCTACC	0.592000													43	72					0	0	1	0	0
GBA3	57733	broad.mit.edu	37	4	22729267	22729267	+	RNA	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr4:22729267G>A	ENST00000511446.1	+	0	61				GBA3_ENST00000503442.1_RNA|GBA3_ENST00000508166.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GGACAGTGGTGAGTTATCTCA	0.413000													34	216					0	0	1	0	0
NPBWR2	2832	broad.mit.edu	37	20	62737878	62737878	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr20:62737878C>A	ENST00000369768.1	-	1	646	c.307G>T	c.(307-309)Gcg>Tcg	p.A103S		NM_005286.2	NP_005277.2	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	103						plasma membrane	opioid receptor activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					AGGTGCTCCGCGATGTTGACG	0.597000													6	42					0.0215528	0.0223157	1	1	0
TCEANC2	127428	broad.mit.edu	37	1	54562017	54562017	+	Silent	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:54562017C>T	ENST00000234827.1	+	5	698	c.498C>T	c.(496-498)ctC>ctT	p.L166L	TCEANC2_ENST00000498272.1_3'UTR|TCEANC2_ENST00000371331.1_Silent_p.L196L	NM_153035.1	NP_694580.1	Q96MN5	TEAN2_HUMAN	transcription elongation factor A (SII) N-terminal and central domain containing 2	166	TFIIS central.				transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|lung(3)|pancreas(1)	5						GCTCCCGCCTCATTAATGGGC	0.498000													6	95					0	0	1	0	0
SPINT2	10653	broad.mit.edu	37	19	38774438	38774438	+	Splice_Site	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr19:38774438G>T	ENST00000301244.7	+	2	712		c.e2+1		SPINT2_ENST00000587090.1_Splice_Site|SPINT2_ENST00000454580.3_Intron	NM_021102.3	NP_066925.1	O43291	SPIT2_HUMAN	serine peptidase inhibitor, Kunitz type, 2						cellular component movement	cytoplasm|extracellular region|integral to membrane|soluble fraction	serine-type endopeptidase inhibitor activity			large_intestine(2)|lung(1)|ovary(1)	4	all_cancers(60;6.83e-07)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ACTGTCACAGGTGAGATGGCA	0.458000													21	47					7.45023e-12	8.89466e-12	1	1	0
KIAA1257	57501	broad.mit.edu	37	3	128706617	128706617	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr3:128706617A>G	ENST00000265068.5	-	4	676	c.509T>C	c.(508-510)tTt>tCt	p.F170S	KIAA1257_ENST00000510149.1_5'UTR|KIAA1257_ENST00000511438.1_Missense_Mutation_p.F170S|KIAA1257_ENST00000515659.1_Missense_Mutation_p.F58S	NM_020741.2	NP_065792.1	Q9ULG3	K1257_HUMAN	KIAA1257	170										breast(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(2)	14						AGTGATATTAAAAGTCTGCTC	0.413000													12	27					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65269385	65269385	+	RNA	SNP	A	A	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr11:65269385A>G	ENST00000534336.1	+	0	4153					NR_002819.2																						GGTTTAGGTAATTGTTTAGTT	0.378000													3	26					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50782414	50782414	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr20:50782414C>G	ENST00000216923.4	-	3	786	c.437G>C	c.(436-438)tGt>tCt	p.C146S	ZFP64_ENST00000361387.2_Missense_Mutation_p.C146S|ZFP64_ENST00000371515.4_Missense_Mutation_p.C144S|ZFP64_ENST00000477786.1_5'UTR|ZFP64_ENST00000346617.4_Intron|ZFP64_ENST00000371518.2_Missense_Mutation_p.C146S	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						TGGATAGCAACAGTTAAGCCT	0.488000													12	51					0	0	1	0	0
DHRS3	9249	broad.mit.edu	37	1	12677258	12677258	+	Silent	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:12677258C>T	ENST00000376223.2	-	1	479	c.96G>A	c.(94-96)aaG>aaA	p.K32K		NM_004753.4	NP_004744.2	O75911	DHRS3_HUMAN	dehydrogenase/reductase (SDR family) member 3	32					retinol metabolic process|visual perception	integral to membrane	electron carrier activity|NADP-retinol dehydrogenase activity|nucleotide binding			cervix(1)|large_intestine(4)|lung(2)|prostate(1)|skin(1)	9	Ovarian(185;0.249)	Lung NSC(185;4.11e-05)|all_lung(284;4.58e-05)|Renal(390;0.000147)|Colorectal(325;0.000585)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|Colorectal(212;9.25e-07)|COAD - Colon adenocarcinoma(227;0.000326)|BRCA - Breast invasive adenocarcinoma(304;0.000344)|Kidney(185;0.00235)|KIRC - Kidney renal clear cell carcinoma(229;0.00656)|STAD - Stomach adenocarcinoma(313;0.00798)|READ - Rectum adenocarcinoma(331;0.0419)	Vitamin A(DB00162)	GGTCCCGCAGCTTGGCGGGCA	0.667000													11	73					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99715611	99715611	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr11:99715611T>A	ENST00000524871.1	+	5	595	c.305T>A	c.(304-306)gTg>gAg	p.V102E	CNTN5_ENST00000279463.3_Missense_Mutation_p.V102E|CNTN5_ENST00000528682.1_Missense_Mutation_p.V102E|CNTN5_ENST00000527185.1_Missense_Mutation_p.V102E|CNTN5_ENST00000418526.2_Missense_Mutation_p.V28E	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	102	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CCAGTTTTTGTGCAAGAACCA	0.348000													14	44					0	0	1	0	0
PDLIM2	64236	broad.mit.edu	37	8	22449117	22449117	+	Missense_Mutation	SNP	G	G	T	rs141780037		TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr8:22449117G>T	ENST00000265810.4	+	8	932	c.817G>T	c.(817-819)Gcc>Tcc	p.A273S	PDLIM2_ENST00000308354.7_Missense_Mutation_p.A523S|PDLIM2_ENST00000339162.7_Intron|PDLIM2_ENST00000397761.2_Missense_Mutation_p.A273S|PDLIM2_ENST00000409417.1_Missense_Mutation_p.A273S|PDLIM2_ENST00000409141.1_Intron|AC037459.4_ENST00000430850.2_Missense_Mutation_p.A67S|PDLIM2_ENST00000397760.4_Missense_Mutation_p.A273S|PDLIM2_ENST00000448520.1_3'UTR	NM_176871.3	NP_789847.1	Q96JY6	PDLI2_HUMAN	PDZ and LIM domain 2 (mystique)	273						actin cytoskeleton|cell surface|cytoplasm|focal adhesion|nucleus	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|urinary_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00579)|Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0626)		CTCCCTGCCCGCCTCCAGGGC	0.662000													3	20					0.115264	0.117269	1	1	0
CDKN2AIP	55602	broad.mit.edu	37	4	184367364	184367364	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr4:184367364C>T	ENST00000504169.1	+	3	734	c.527C>T	c.(526-528)tCa>tTa	p.S176L	CDKN2AIP_ENST00000302350.4_3'UTR|CDKN2AIP_ENST00000506835.1_3'UTR	NM_017632.2	NP_060102.1	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	176	Ser-rich.				negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(1)	6		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GAAAACAGTTCAACGTGTATA	0.468000													7	74					0	0	1	0	0
SWAP70	23075	broad.mit.edu	37	11	9770693	9770693	+	Silent	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr11:9770693G>A	ENST00000318950.6	+	11	1717	c.1614G>A	c.(1612-1614)gtG>gtA	p.V538V	SWAP70_ENST00000447399.2_Silent_p.V480V	NM_015055.2	NP_055870.2	Q9UH65	SWP70_HUMAN	SWAP switching B-cell complex 70kDa subunit	538						cytoplasm|lamellipodium|nucleus|plasma membrane	calcium ion binding|DNA binding			NS(1)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	11				all cancers(16;1.21e-10)|Epithelial(150;2.81e-09)|BRCA - Breast invasive adenocarcinoma(625;0.00649)		AGGACAAAGTGGCCCATCATG	0.338000													5	43					0	0	1	0	0
IRX4	50805	broad.mit.edu	37	5	1879834	1879834	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr5:1879834C>T	ENST00000505790.1	-	5	976	c.520G>A	c.(520-522)Gag>Aag	p.E174K	IRX4_ENST00000513692.1_Missense_Mutation_p.E174K|IRX4_ENST00000505938.1_5'UTR|IRX4_ENST00000231357.2_Missense_Mutation_p.E174K	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	174					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		ATGATCTTCTCGCCCTTGGTG	0.637000													7	125					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20990681	20990681	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr16:20990681A>T	ENST00000261383.3	-	50	8046	c.8047T>A	c.(8047-8049)Ttg>Atg	p.L2683M	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2683	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGTTTCTGCAAGCCTGTCAGG	0.522000													25	37					0	0	1	0	0
WRN	7486	broad.mit.edu	37	8	30948004	30948004	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr8:30948004C>T	ENST00000298139.5	+	14	1925	c.1676C>T	c.(1675-1677)tCa>tTa	p.S559L		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	559	Helicase ATP-binding.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		GTGATTCATTCAGTATTAGAA	0.289000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				7	123					0	0	1	0	0
NBPF14	25832	broad.mit.edu	37	1	148012531	148012531	+	Silent	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:148012531C>T	ENST00000369219.1	-	12	1444	c.1428G>A	c.(1426-1428)aaG>aaA	p.K476K				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	476	NBPF 5.					cytoplasm		p.K476K(2)|p.K476N(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					AGCCAACATGCTTTTCCTCCA	0.443000													5	10					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657809	72657809	+	RNA	SNP	T	T	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr7:72657809T>A	ENST00000425256.1	-	0	2102					NR_002164.1																						gatcaggtcatacatctgcgt	0.498000													13	259					0	0	1	0	0
SENP5	205564	broad.mit.edu	37	3	196626846	196626846	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr3:196626846A>T	ENST00000323460.5	+	4	1920	c.1671A>T	c.(1669-1671)aaA>aaT	p.K557N	SENP5_ENST00000419026.1_Missense_Mutation_p.K47N|SENP5_ENST00000445299.2_Missense_Mutation_p.K557N	NM_152699.4	NP_689912.2	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	557					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(14)|skin(1)	32	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		GACATCAAAAATGTAACTTCC	0.363000													13	37					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32624298	32624298	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr21:32624298G>T	ENST00000286827.3	-	6	1642	c.1171C>A	c.(1171-1173)Ctg>Atg	p.L391M	TIAM1_ENST00000469412.1_5'UTR|TIAM1_ENST00000541036.1_Missense_Mutation_p.L391M	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	391					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CTCATCTCCAGCTCCCGCCGG	0.692000													6	73					0.00116845	0.00126582	1	1	0
ZNF431	170959	broad.mit.edu	37	19	21350417	21350417	+	Silent	SNP	A	A	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr19:21350417A>G	ENST00000311048.7	+	4	411	c.267A>G	c.(265-267)caA>caG	p.Q89Q	ZNF431_ENST00000599296.1_Silent_p.Q89Q|ZNF431_ENST00000594425.1_Intron|ZNF431_ENST00000600692.1_Silent_p.Q89Q	NM_133473.2	NP_597730.2	Q8TF32	ZN431_HUMAN	zinc finger protein 431	89	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23						GTCTGGAGCAAGAAAAAGAGC	0.408000													18	72					0	0	1	0	0
SLC22A20	440044	broad.mit.edu	37	11	65004286	65004286	+	RNA	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr11:65004286G>T	ENST00000525437.1	+	0	1536							A6NK97	S22AK_HUMAN							ion transport	integral to membrane	transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(2)	8						AATCCTGGCTGGGCTGGCCGT	0.682000													12	67					4.3838e-07	5.02848e-07	1	1	0
MAPK14	1432	broad.mit.edu	37	6	36043628	36043628	+	Silent	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr6:36043628C>T	ENST00000229795.3	+	7	946	c.499C>T	c.(499-501)Ctg>Ttg	p.L167L	MAPK14_ENST00000229794.4_Silent_p.L167L|MAPK14_ENST00000310795.4_Silent_p.L167L|MAPK14_ENST00000468133.1_Silent_p.L90L	NM_001315.2	NP_001306.1	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14	167	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|stomach(1)	16						CCTTTAGATTCTGGATTTTGG	0.448000													8	38					0	0	1	0	0
RBM12	10137	broad.mit.edu	37	20	34243194	34243194	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr20:34243194C>T	ENST00000374114.3	-	3	314	c.51G>A	c.(49-51)atG>atA	p.M17I	RBM12_ENST00000374104.3_Missense_Mutation_p.M17I|CPNE1_ENST00000352393.4_5'UTR|RBM12_ENST00000359646.1_Missense_Mutation_p.M17I|CPNE1_ENST00000397442.1_Intron|CPNE1_ENST00000397446.1_5'UTR|CPNE1_ENST00000397443.1_Intron|CPNE1_ENST00000317619.3_5'UTR|CPNE1_ENST00000397445.1_Intron	NM_001198838.1|NM_001198840.1|NM_006047.5	NP_001185767.1|NP_001185769.1|NP_006038.2	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	17						nucleus	nucleotide binding|protein binding|RNA binding			breast(3)|endometrium(7)|kidney(1)|large_intestine(3)|lung(14)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GGCGAATGTCCATGGTCCCCG	0.542000											OREG0004046	type=REGULATORY REGION|Gene=RBM12|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	18	19					0	0	1	0	0
ZNHIT3	9326	broad.mit.edu	37	17	34849832	34849832	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr17:34849832C>G	ENST00000225410.4	+	4	333	c.268C>G	c.(268-270)Cag>Gag	p.Q90E	ZNHIT3_ENST00000592616.1_Missense_Mutation_p.Q90E|ZNHIT3_ENST00000588253.1_5'UTR|ZNHIT3_ENST00000590858.1_Intron|ZNHIT3_ENST00000490126.2_5'UTR	NM_004773.2	NP_004764.1	Q15649	ZNHI3_HUMAN	zinc finger, HIT-type containing 3	90					regulation of transcription, DNA-dependent	intracellular	metal ion binding|thyroid hormone receptor binding			lung(1)|pancreas(1)|prostate(1)	3		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0188)		AGTTTCTTTGCAGAATTTAAA	0.318000													9	93					0	0	1	0	0
NLGN4Y	22829	broad.mit.edu	37	Y	16734057	16734057	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chrY:16734057A>T	ENST00000297967.5	+	1	157	c.58A>T	c.(58-60)Atg>Ttg	p.M20L	NLGN4Y_ENST00000476359.1_3'UTR	NM_001164238.1	NP_001157710.1	Q8NFZ3	NLGNY_HUMAN	neuroligin 4, Y-linked	20					brainstem development|cell adhesion|cerebellum development|male courtship behavior|positive regulation of organ growth|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|integral to plasma membrane|synapse	neurexin binding|receptor activity			large_intestine(3)|lung(7)|prostate(2)|skin(2)	14						TGTCTGTGTCATGTTAAACTC	0.468000													31	15					0	0	1	0	0
LGALS16	148003	broad.mit.edu	37	19	40149108	40149108	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr19:40149108C>A	ENST00000392051.3	+	3	169	c.101C>A	c.(100-102)cCa>cAa	p.P34Q		NM_001190441.1	NP_001177370.1	A8MUM7	A8MUM7_HUMAN	lectin, galactoside-binding, soluble, 16	34							sugar binding										AGCAACGAACCACAGCTGCAG	0.498000													4	12					0.150653	0.151952	1	1	0
DGKG	1608	broad.mit.edu	37	3	185985530	185985530	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr3:185985530C>T	ENST00000265022.3	-	13	1692	c.1153G>A	c.(1153-1155)Ggt>Agt	p.G385S	DGKG_ENST00000382164.4_Missense_Mutation_p.G346S|DGKG_ENST00000344484.4_Missense_Mutation_p.G385S|DGKG_ENST00000544847.1_Missense_Mutation_p.G346S	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	385					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	AGTTCCCCACCGTCACACAAC	0.517000													7	96					0	0	1	0	0
ABCA1	19	broad.mit.edu	37	9	107651438	107651438	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr9:107651438G>C	ENST00000374736.3	-	3	499	c.105C>G	c.(103-105)atC>atG	p.I35M	ABCA1_ENST00000374733.1_De_novo_Start_InFrame|ABCA1_ENST00000423487.2_Missense_Mutation_p.I35M	NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	35					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GGATCAGGAAGATAAATAGAG	0.438000													5	50					0	0	1	0	0
HEXA	3073	broad.mit.edu	37	15	72638941	72638941	+	Silent	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr15:72638941G>T	ENST00000268097.5	-	11	1760	c.1257C>A	c.(1255-1257)ccC>ccA	p.P419P	HEXA_ENST00000457859.2_Intron|HEXA_ENST00000567159.1_Silent_p.P419P|HEXA_ENST00000566304.1_Silent_p.P430P|RP11-106M3.3_ENST00000570175.1_RNA|HEXA_ENST00000429918.2_Silent_p.P246P|RP11-106M3.2_ENST00000379915.4_RNA	NM_000520.4	NP_000511.2	P06865	HEXA_HUMAN	hexosaminidase A (alpha polypeptide)	419					cell death	lysosome	beta-N-acetylhexosaminidase activity|cation binding|protein heterodimerization activity	p.P419P(1)		breast(2)|cervix(1)|endometrium(3)|kidney(3)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	24						TCAGGTACCAGGGGGCAGAGA	0.517000													10	158					0.000442599	0.000488529	1	1	0
RASGEF1A	221002	broad.mit.edu	37	10	43697256	43697256	+	Splice_Site	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr10:43697256C>T	ENST00000395809.1	-	4	2965	c.459_splice	c.e4+1	p.E153_splice	RASGEF1A_ENST00000374459.1_Splice_Site_p.E161_splice|RASGEF1A_ENST00000472864.1_5'UTR|RASGEF1A_ENST00000395810.1_Splice_Site_p.E153_splice			Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	153	N-terminal Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)	11						GAGCACTCACCTCATCACACT	0.617000													5	13					0	0	1	0	0
ZNF345	25850	broad.mit.edu	37	19	37368460	37368460	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr19:37368460C>A	ENST00000529555.1	+	2	1516	c.728C>A	c.(727-729)tCg>tAg	p.S243*	ZNF345_ENST00000432005.2_Intron|ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000589046.1_Nonsense_Mutation_p.S243*|ZNF345_ENST00000420450.1_Nonsense_Mutation_p.S243*			Q14585	ZN345_HUMAN	zinc finger protein 345	243					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|ovary(2)|prostate(1)	24	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGCAGTGGTTCGGCTCTTACT	0.443000													19	53					6.94344e-10	8.20589e-10	1	1	0
RBBP4	5928	broad.mit.edu	37	1	33138267	33138267	+	Silent	SNP	A	A	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:33138267A>G	ENST00000373493.5	+	10	1227	c.1068A>G	c.(1066-1068)ccA>ccG	p.P356P	RBBP4_ENST00000414241.3_Silent_p.P355P|RBBP4_ENST00000544435.1_Silent_p.P104P|RBBP4_ENST00000373485.1_Silent_p.P356P|RBBP4_ENST00000458695.2_Silent_p.P321P	NM_001135255.1|NM_005610.2	NP_001128727.1|NP_005601.1	Q09028	RBBP4_HUMAN	retinoblastoma binding protein 4	356					cell cycle|CenH3-containing nucleosome assembly at centromere|DNA replication|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|ESC/E(Z) complex|NuRD complex|NURF complex|Sin3 complex	histone binding|histone deacetylase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				AACAATCCCCAGAAGATGCAG	0.358000													6	35					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58620552	58620552	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr16:58620552T>C	ENST00000317147.5	-	7	866	c.534A>G	c.(532-534)atA>atG	p.I178M	CNOT1_ENST00000569240.1_Missense_Mutation_p.I178M|CNOT1_ENST00000441024.2_Missense_Mutation_p.I178M	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	178					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GTAGGACCTCTATTGCTATAT	0.483000													43	235					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1527480	1527480	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr7:1527480C>A	ENST00000389470.4	-	20	2815	c.2816G>T	c.(2815-2817)gGg>gTg	p.G939V	INTS1_ENST00000404767.3_Missense_Mutation_p.G811V			Q8N201	INT1_HUMAN	integrator complex subunit 1	811					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CGCCAGGTGCCCCTCGAAGGC	0.667000													13	80					0.00136819	0.00146861	1	1	0
AK9	221264	broad.mit.edu	37	6	109983767	109983767	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr6:109983767A>G	ENST00000424296.2	-	6	507	c.431T>C	c.(430-432)aTa>aCa	p.I144T	AK9_ENST00000368948.2_Missense_Mutation_p.I144T|AK9_ENST00000341338.6_5'UTR|AK9_ENST00000285397.5_Missense_Mutation_p.I144T	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		TATATTGATTATAACATCAGG	0.274000													9	47					0	0	1	0	0
HEATR1	55127	broad.mit.edu	37	1	236734889	236734889	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:236734889C>G	ENST00000366582.3	-	27	3919	c.3805G>C	c.(3805-3807)Gat>Cat	p.D1269H	HEATR1_ENST00000366581.2_Missense_Mutation_p.D1188H	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1269					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTGCCACCATCTGGAGATAGT	0.393000													5	70					0	0	1	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281117	49281117	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr13:49281117G>A	ENST00000282018.3	+	1	167	c.164G>A	c.(163-165)gGa>gAa	p.G55E		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	55					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	GGAGTCTTGGGAAATGGGTTG	0.378000													15	53					0	0	1	0	0
SPEF1	25876	broad.mit.edu	37	20	3761874	3761874	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr20:3761874G>A	ENST00000379756.3	-	1	221	c.61C>T	c.(61-63)Cct>Tct	p.P21S	SPEF1_ENST00000463490.1_5'UTR	NM_015417.4	NP_056232.2	Q9Y4P9	SPEF1_HUMAN	sperm flagellar 1	21						cilium axoneme|cytoplasm|cytoskeleton				cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8						CGGGACAGAGGGATGTTGTCT	0.627000													8	47					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55805488	55805488	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr19:55805488G>A	ENST00000309383.1	+	5	839	c.562G>A	c.(562-564)Gag>Aag	p.E188K	BRSK1_ENST00000590333.1_Missense_Mutation_p.E204K|BRSK1_ENST00000585418.1_Missense_Mutation_p.E188K	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	188	Protein kinase.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CAGCCTCCTGGAGACCAGCTG	0.612000													9	180					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72346069	72346069	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr18:72346069C>G	ENST00000299687.5	+	1	3094	c.3094C>G	c.(3094-3096)Cta>Gta	p.L1032V	ZNF407_ENST00000309902.6_Missense_Mutation_p.L1032V|ZNF407_ENST00000577538.1_Missense_Mutation_p.L1032V|ZNF407_ENST00000582337.1_Missense_Mutation_p.L1032V	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	1032					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CTCTGCTTCTCTAGAGCTGCA	0.493000													7	87					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3235197	3235197	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chrX:3235197C>T	ENST00000217939.6	-	6	6679	c.6525G>A	c.(6523-6525)tgG>tgA	p.W2175*		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2175	Ig-like C2-type 6.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGATGCGCGGCCAGGGGTCCC	0.677000													5	5					0	0	1	0	0
ASNSD1	54529	broad.mit.edu	37	2	190531771	190531771	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr2:190531771G>T	ENST00000260952.4	+	4	1326	c.913G>T	c.(913-915)Gaa>Taa	p.E305*	ASNSD1_ENST00000607062.1_Intron	NM_019048.2	NP_061921.1	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	305	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(3)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			ACCTAGGGATGAAAACCTGAC	0.403000													26	208					1.17739e-12	1.42015e-12	1	1	0
GALNT16	57452	broad.mit.edu	37	14	69814736	69814736	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr14:69814736C>T	ENST00000553669.1	+	14	1556	c.1556C>T	c.(1555-1557)tCt>tTt	p.S519F	GALNT16_ENST00000448469.3_Intron|GALNT16_ENST00000337827.4_Intron					UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		CTCCTTGCCTCTGGCCCAGAG	0.602000													6	38					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8421438	8421438	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:8421438C>T	ENST00000337907.3	-	19	2763	c.2129G>A	c.(2128-2130)aGc>aAc	p.S710N	RERE_ENST00000400908.2_Missense_Mutation_p.S710N|RERE_ENST00000377464.1_Missense_Mutation_p.S442N|RERE_ENST00000476556.1_Missense_Mutation_p.S156N|RERE_ENST00000400907.2_Intron	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	710					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CGGGGACGTGCTGCGATTGTC	0.617000													12	55					0	0	1	0	0
ABCA8	10351	broad.mit.edu	37	17	66879937	66879937	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr17:66879937G>T	ENST00000269080.2	-	27	3719	c.3582C>A	c.(3580-3582)ttC>ttA	p.F1194L	ABCA8_ENST00000586539.1_Missense_Mutation_p.F1234L|ABCA8_ENST00000430352.2_Missense_Mutation_p.F1234L	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1194						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					CCAACCTAAAGAAAGGATCCT	0.303000													7	25					0.00448238	0.00472467	1	1	0
MTMR11	10903	broad.mit.edu	37	1	149901551	149901551	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:149901551C>T	ENST00000439741.2	-	16	2155	c.1905G>A	c.(1903-1905)tgG>tgA	p.W635*	MTMR11_ENST00000369140.3_Nonsense_Mutation_p.W563*|MTMR11_ENST00000406732.3_3'UTR|MTMR11_ENST00000492824.1_5'UTR|MTMR11_ENST00000361405.6_3'UTR	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	635	Myotubularin phosphatase.						phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			AGCAGCGTCTCCAGAGCCTGA	0.582000													9	183					0	0	1	0	0
ACAD8	27034	broad.mit.edu	37	11	134126982	134126982	+	Splice_Site	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr11:134126982G>A	ENST00000281182.4	+	3	317	c.210_splice	c.e3-1	p.E71_splice	ACAD8_ENST00000524547.1_Intron|ACAD8_ENST00000543332.1_Intron|ACAD8_ENST00000537423.1_5'UTR|ACAD8_ENST00000374752.4_Intron	NM_014384.2	NP_055199.1	Q9UKU7	ACAD8_HUMAN	acyl-CoA dehydrogenase family, member 8	71					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		TTGTACATAGGAGCTGTTCCC	0.552000													6	78					0	0	1	0	0
IL2RA	3559	broad.mit.edu	37	10	6067955	6067955	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr10:6067955T>A	ENST00000379959.3	-	2	271	c.98A>T	c.(97-99)cAc>cTc	p.H33L	IL2RA_ENST00000379954.1_Missense_Mutation_p.H33L|RP11-536K7.5_ENST00000440436.1_RNA|IL2RA_ENST00000256876.6_Missense_Mutation_p.H33L	NM_000417.2	NP_000408.1	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha	33	Sushi 1.				cell proliferation	integral to membrane	interleukin-2 receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	17					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	GAATGTGGCGTGTGGGATCTC	0.478000													28	36					0	0	1	0	0
SYBU	55638	broad.mit.edu	37	8	110587689	110587689	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr8:110587689C>G	ENST00000399066.3	-	6	2156	c.1429G>C	c.(1429-1431)Ggc>Cgc	p.G477R	SYBU_ENST00000533895.1_Missense_Mutation_p.G479R|SYBU_ENST00000419099.1_Missense_Mutation_p.G479R|SYBU_ENST00000422135.1_Missense_Mutation_p.G480R|SYBU_ENST00000440310.1_Missense_Mutation_p.G480R|SYBU_ENST00000408908.2_Missense_Mutation_p.G480R|SYBU_ENST00000533171.1_Missense_Mutation_p.G480R|SYBU_ENST00000528647.1_Missense_Mutation_p.G479R|SYBU_ENST00000408889.3_Missense_Mutation_p.G361R|SYBU_ENST00000433638.1_Missense_Mutation_p.G480R|SYBU_ENST00000424158.2_Missense_Mutation_p.G485R|SYBU_ENST00000529690.1_Missense_Mutation_p.G350R|SYBU_ENST00000528331.1_Missense_Mutation_p.G361R|SYBU_ENST00000446070.2_Missense_Mutation_p.G479R|SYBU_ENST00000532779.1_Missense_Mutation_p.G412R|SYBU_ENST00000533065.1_Missense_Mutation_p.G361R|SYBU_ENST00000276646.9_Missense_Mutation_p.G480R|SYBU_ENST00000529175.1_Missense_Mutation_p.G274R	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	480						cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						ACCACACTGCCCTCCTCCTGA	0.612000													11	73					0	0	1	0	0
NEDD1	121441	broad.mit.edu	37	12	97331052	97331052	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr12:97331052G>A	ENST00000266742.4	+	9	1337	c.998G>A	c.(997-999)gGa>gAa	p.G333E	NEDD1_ENST00000557644.1_Missense_Mutation_p.G340E|NEDD1_ENST00000457368.2_Missense_Mutation_p.G244E|NEDD1_ENST00000411739.2_Missense_Mutation_p.G244E|NEDD1_ENST00000429527.2_Missense_Mutation_p.G333E	NM_152905.3	NP_690869.1	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally down-regulated 1	333					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol				breast(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)	22						GCTGCTAGTGGAGGAGTTCAG	0.408000													8	84					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111509639	111509639	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr7:111509639C>A	ENST00000428084.1	-	21	2372	c.2100G>T	c.(2098-2100)gaG>gaT	p.E700D	DOCK4_ENST00000437633.1_Missense_Mutation_p.E700D|DOCK4_ENST00000476846.1_5'UTR			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	700					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				CCTTCAGCACCTCCTGGATAT	0.438000													4	40					0.014758	0.0154168	1	1	0
LY75	4065	broad.mit.edu	37	2	160673443	160673443	+	Silent	SNP	T	T	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr2:160673443T>A	ENST00000263636.4	-	30	4281	c.4254A>T	c.(4252-4254)gcA>gcT	p.A1418A	LY75_ENST00000553424.1_Silent_p.A1418A|LY75-CD302_ENST00000505052.1_Silent_p.A1418A|LY75-CD302_ENST00000504764.1_Silent_p.A1418A|LY75_ENST00000554112.1_Silent_p.A1418A	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		ACATGTTTAATGCTTCATACC	0.368000													22	57					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586291	20586291	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr14:20586291C>G	ENST00000315543.4	+	1	726	c.726C>G	c.(724-726)ttC>ttG	p.F242L		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TGAGCTGTTTCATTATTTTGC	0.418000													66	79					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72680525	72680525	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr12:72680525C>T	ENST00000261180.4	+	2	940	c.844C>T	c.(844-846)Cca>Tca	p.P282S		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	282					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TTTTGATGAGCCAATCTACAA	0.373000													14	99					0	0	1	0	0
BDH1	622	broad.mit.edu	37	3	197241159	197241159	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr3:197241159G>C	ENST00000392379.1	-	7	939	c.538C>G	c.(538-540)Ctc>Gtc	p.L180V	BDH1_ENST00000392378.2_Missense_Mutation_p.L180V|BDH1_ENST00000441275.1_Missense_Mutation_p.L93V|BDH1_ENST00000358186.2_Missense_Mutation_p.L180V	NM_203314.2	NP_976059.1	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	180					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			endometrium(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	ATGAGGGGGAGAAAGGATTTC	0.562000													9	30					0	0	1	0	0
TFIP11	24144	broad.mit.edu	37	22	26888076	26888076	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr22:26888076C>T	ENST00000407690.1	-	15	2700	c.2417G>A	c.(2416-2418)cGc>cAc	p.R806H	TFIP11_ENST00000405938.1_Missense_Mutation_p.R806H|TFIP11_ENST00000407431.1_Missense_Mutation_p.R806H|TFIP11_ENST00000407148.1_Missense_Mutation_p.R806H	NM_012143.2	NP_036275.1	Q9UBB9	TFP11_HUMAN	tuftelin interacting protein 11	806					biomineral tissue development	catalytic step 2 spliceosome|cytoplasm|nuclear speck	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	25						GATCACAATGCGGCCAAAGGT	0.547000													3	19					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846450	43846450	+	Silent	SNP	T	T	C			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr12:43846450T>C	ENST00000389420.3	-	13	1808	c.1809A>G	c.(1807-1809)cgA>cgG	p.R603R	ADAMTS20_ENST00000553158.1_Silent_p.R603R	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	603	TSP type-1 1.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TATTACATGATCGAAATTTCA	0.398000													5	25					0	0	1	0	0
USP20	10868	broad.mit.edu	37	9	132632069	132632069	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr9:132632069G>A	ENST00000315480.4	+	14	1669	c.1511G>A	c.(1510-1512)gGg>gAg	p.G504E	USP20_ENST00000372429.3_Missense_Mutation_p.G504E|USP20_ENST00000358355.1_Missense_Mutation_p.G504E			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	504					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				GGCGCCTGTGGGGACAGCTAT	0.622000													22	63					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	55768825	55768825	+	Silent	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr3:55768825G>T	ENST00000288221.6	-	15	2941	c.2686C>A	c.(2686-2688)Cga>Aga	p.R896R		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	896						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TGTACTAGTCGGTCTTTTTCC	0.478000													3	22					0.115264	0.117269	1	1	0
CCHCR1	54535	broad.mit.edu	37	6	31118624	31118624	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr6:31118624C>G	ENST00000396268.3	-	6	1167	c.979G>C	c.(979-981)Gac>Cac	p.D327H	CCHCR1_ENST00000480060.1_Intron|CCHCR1_ENST00000376266.5_Missense_Mutation_p.D238H|CCHCR1_ENST00000451521.2_Missense_Mutation_p.D291H|CCHCR1_ENST00000396263.2_Missense_Mutation_p.D238H	NM_001105563.1|NM_001105564.1	NP_001099033.1|NP_001099034.1	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1	238					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(13)|skin(1)	23						GCCTCCAAGTCTTCCTGGGTC	0.567000													29	196					0	0	1	0	0
MYL9	10398	broad.mit.edu	37	20	35176517	35176517	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr20:35176517G>T	ENST00000279022.2	+	3	371	c.267G>T	c.(265-267)atG>atT	p.M89I	RP5-977B1.7_ENST00000439595.1_RNA|RP5-977B1.7_ENST00000425233.1_RNA|MYL9_ENST00000346786.2_Intron	NM_006097.4	NP_006088.2	P24844	MYL9_HUMAN	myosin, light chain 9, regulatory	89					axon guidance|muscle contraction|regulation of muscle contraction	cytosol|muscle myosin complex	calcium ion binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(3)|lung(2)	8	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				TCCTCACCATGTTTGGGGAGA	0.617000													9	41					7.48243e-07	8.41773e-07	1	1	0
MEIS1	4211	broad.mit.edu	37	2	66739372	66739372	+	Silent	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr2:66739372C>T	ENST00000488550.1	+	8	1133	c.834C>T	c.(832-834)atC>atT	p.I278I	MEIS1_ENST00000409517.1_Intron|MEIS1_ENST00000407092.2_Silent_p.I278I|MEIS1_ENST00000398506.2_Silent_p.I276I|MEIS1_ENST00000495021.2_Silent_p.I213I|MEIS1_ENST00000560281.2_Silent_p.I278I|MEIS1_ENST00000272369.9_Silent_p.I278I|MEIS1_ENST00000444274.2_Intron			O00470	MEIS1_HUMAN	Meis homeobox 1	278							sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	24						AGCGTGGCATCTTTCCCAAAG	0.438000													4	23					0	0	1	0	0
IFT81	28981	broad.mit.edu	37	12	110581239	110581239	+	Silent	SNP	T	T	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr12:110581239T>A	ENST00000242591.5	+	9	1340	c.834T>A	c.(832-834)acT>acA	p.T278T	IFT81_ENST00000549009.1_3'UTR|IFT81_ENST00000361948.4_Silent_p.T278T|IFT81_ENST00000552912.1_Silent_p.T278T	NM_014055.3	NP_054774.2	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81 homolog (Chlamydomonas)	278					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)	10						ATATGGTAACTGAAAAATTTC	0.284000													8	26					0	0	1	0	0
TRBC2	28638	broad.mit.edu	37	7	142498902	142498902	+	RNA	SNP	C	C	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr7:142498902C>T	ENST00000466254.1	+	0	178																											AGCACAGACCCGCAGCCCCTC	0.652000													8	105					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50664767	50664767	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr22:50664767C>G	ENST00000439308.2	-	8	2134	c.1642G>C	c.(1642-1644)Gct>Cct	p.A548P	TUBGCP6_ENST00000248846.5_Missense_Mutation_p.A548P	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	548					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TCGCCATAAGCGTCTCTGAAC	0.612000													11	17					0	0	1	0	0
FCN2	2220	broad.mit.edu	37	9	137777146	137777146	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr9:137777146C>G	ENST00000350339.2	+	4	263	c.249C>G	c.(247-249)atC>atG	p.I83M	FCN2_ENST00000291744.6_Missense_Mutation_p.I121M	NM_015837.2	NP_056652.1	Q15485	FCN2_HUMAN	ficolin (collagen/fibrinogen domain containing lectin) 2	121	Collagen-like.				complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	20		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		GGCACACCATCTACCTGCCCG	0.677000													5	38					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451567	55451567	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr19:55451567G>A	ENST00000446217.1	-	6	1106	c.704C>T	c.(703-705)gCg>gTg	p.A235V	NLRP7_ENST00000448121.2_Missense_Mutation_p.A207V|NLRP7_ENST00000340844.2_Missense_Mutation_p.A207V|NLRP7_ENST00000328092.5_Missense_Mutation_p.A207V|NLRP7_ENST00000592784.1_Missense_Mutation_p.A207V|NLRP7_ENST00000590030.1_Missense_Mutation_p.A207V|NLRP7_ENST00000588756.1_Missense_Mutation_p.A207V			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	207	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		GAGGTAGAACGCGTATCTGAG	0.587000													24	61					0	0	1	0	0
HMGCS1	3157	broad.mit.edu	37	5	43292578	43292578	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr5:43292578C>G	ENST00000325110.6	-	10	1677	c.1471G>C	c.(1471-1473)Gag>Cag	p.E491Q	HMGCS1_ENST00000433297.2_Missense_Mutation_p.E491Q	NM_001098272.2	NP_001091742.1	Q01581	HMCS1_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	491					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|stomach(1)|urinary_tract(1)	15						TTATTTACCTCAGTTGCTATG	0.418000													4	53					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90321635	90321635	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr9:90321635A>C	ENST00000469640.2	+	27	4099	c.3724A>C	c.(3724-3726)Agc>Cgc	p.S1242R	DAPK1_ENST00000358077.5_Missense_Mutation_p.S1217R|DAPK1_ENST00000491893.1_Missense_Mutation_p.S1151R|DAPK1_ENST00000472284.1_Missense_Mutation_p.S1217R|DAPK1_ENST00000408954.3_Missense_Mutation_p.S1217R			P53355	DAPK1_HUMAN	death-associated protein kinase 1	1217					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						CTCGGTGTGCAGCACCATTGA	0.637000									Chronic Lymphocytic Leukemia, Familial Clustering of				5	37					0	0	1	0	0
IFNA17	3451	broad.mit.edu	37	9	21227650	21227650	+	Missense_Mutation	SNP	G	G	A	rs143565460	byFrequency	TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr9:21227650G>A	ENST00000413767.2	-	1	571	c.523C>T	c.(523-525)Ctc>Ttc	p.L175F		NM_021268.2	NP_067091.1	P01571	IFN17_HUMAN	interferon, alpha 17	175					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(1)|endometrium(2)|lung(4)|ovary(1)|skin(1)	9				Lung(24;2.13e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		GAAAAAGAGAGAGATCTCATG	0.383000													50	82					0	0	1	0	0
SGSM3	27352	broad.mit.edu	37	22	40803490	40803490	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr22:40803490A>T	ENST00000248929.9	+	13	1631	c.1442A>T	c.(1441-1443)cAc>cTc	p.H481L	SGSM3_ENST00000454798.2_Missense_Mutation_p.H414L	NM_015705.4	NP_056520.2	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	481	SH3.				cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)	19						TCACGCAGCCACCGGCGCCGA	0.637000													17	17					0	0	1	0	0
LOC100288069	100288069	broad.mit.edu	37	1	700514	700514	+	RNA	DEL	A	A	-			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr1:700514delA	ENST00000428504.1	-	0	1039					NR_033908.1																						actccatctcaaaaaaaaaaa	0.453													3	4	---	---	---	---					
ZEB1	6935	broad.mit.edu	37	10	31810011	31810011	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr10:31810011delC	ENST00000446923.2	+	7	2091	c.1700delC	c.(1699-1701)ttfs	p.S567fs	ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000320985.10_Frame_Shift_Del_p.S583fs|ZEB1_ENST00000361642.5_Frame_Shift_Del_p.S584fs|ZEB1_ENST00000542815.3_Frame_Shift_Del_p.S516fs|ZEB1_ENST00000560721.2_Frame_Shift_Del_p.S563fs	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	583					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				GGCAATTTGTCTCCTAGTCAG	0.458													19	47	---	---	---	---					
EXOSC1	51013	broad.mit.edu	37	10	99203050	99203050	+	Frame_Shift_Del	DEL	C	C	-	rs111511939	byFrequency	TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr10:99203050delC	ENST00000370902.3	-	3	197	c.166delG	c.(166-168)tgfs	p.V56fs	EXOSC1_ENST00000370885.4_Intron|EXOSC1_ENST00000370886.5_Frame_Shift_Del_p.V56fs|EXOSC1_ENST00000485122.2_Frame_Shift_Del_p.V56fs|EXOSC1_ENST00000471049.1_5'UTR	NM_016046.3	NP_057130.1	Q9Y3B2	EXOS1_HUMAN	exosome component 1	56					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	protein binding|RNA binding			breast(1)|endometrium(1)|lung(5)	7		Renal(717;0.000147)|Colorectal(252;0.00205)|Ovarian(717;0.00965)		all cancers(201;8.29e-42)|Epithelial(162;5.7e-33)|BRCA - Breast invasive adenocarcinoma(275;0.000315)|Kidney(138;0.000832)|KIRC - Kidney renal clear cell carcinoma(50;0.00269)|STAD - Stomach adenocarcinoma(243;0.202)		GTTTCTCTCACTACAGACACC	0.448													8	152	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23299147	23299147	+	RNA	DEL	A	A	-			TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr15:23299147delA	ENST00000560464.1	-	0	4510																											ACATTCAAAGAAAAAAAAAAA	0.313													6	7	---	---	---	---					
IGLC2	3538	broad.mit.edu	37	22	23243490	23243490	+	RNA	DEL	C	C	-	rs67516365		TCGA-MP-A4T2-01A-11D-A24P-08	TCGA-MP-A4T2-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e9f8f93-c0c2-4a5f-8a25-1122122d8ec2	6503c1b2-2d9b-4e0a-aad9-130f513be0ee	g.chr22:23243490delC	ENST00000390323.2	+	0	335																											TCAACCCTCACCCCCCACCAC	0.587													2	4	---	---	---	---