Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PABPC1L	80336	broad.mit.edu	37	20	43559304	43559304	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:43559304G>A	ENST00000255136.3	+	8	1258	c.1176G>A	c.(1174-1176)ctG>ctA	p.L392L	PABPC1L_ENST00000217073.2_Silent_p.L392L|PABPC1L_ENST00000217074.4_3'UTR|PABPC1L_ENST00000537323.1_3'UTR|PABPC1L_ENST00000490798.1_3'UTR	NM_001124756.1	NP_001118228.1	Q4VXU2	PAP1L_HUMAN	poly(A) binding protein, cytoplasmic 1-like	392							nucleotide binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	20						TGCGGACCCTGAGCAACCCCC	0.652000													17	230					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111749980	111749980	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:111749980G>A	ENST00000261726.6	+	16	2131	c.1977G>A	c.(1975-1977)aaG>aaA	p.K659K		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	659						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						AGCAGGCCAAGAAGGAGATCG	0.617000													6	16					0	0	1	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50677799	50677799	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:50677799C>T	ENST00000446044.1	+	5	818	c.222C>T	c.(220-222)ctC>ctT	p.L74L	MAPKAPK3_ENST00000357955.2_Silent_p.L74L	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	74	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		ACCTACAGCTCCTGTATGACA	0.542000													47	148					0	0	1	0	0
ERG	2078	broad.mit.edu	37	21	39947589	39947589	+	Translation_Start_Site	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr21:39947589G>C	ENST00000398897.1	-	0	139				ERG_ENST00000398911.1_Missense_Mutation_p.I12M|ERG_ENST00000442448.1_Missense_Mutation_p.I12M|ERG_ENST00000398919.2_Missense_Mutation_p.I12M|ERG_ENST00000417133.2_Missense_Mutation_p.I12M|ERG_ENST00000398910.1_Missense_Mutation_p.I12M|ERG_ENST00000485493.1_5'UTR	NM_001243429.1	NP_001230358.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog						cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				GACTTACCTTGATATGAGCTG	0.512000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								6	36					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5536578	5536578	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:5536578G>T	ENST00000380184.1	-	1	1357	c.1094C>A	c.(1093-1095)aCc>aAc	p.T365N	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	365										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		CTGGCCCTTGGTGGAAATCAT	0.478000													33	94					1.66425e-11	1.97846e-11	1	1	0
KLHL2	11275	broad.mit.edu	37	4	166232659	166232659	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:166232659G>T	ENST00000226725.6	+	11	1540	c.1281G>T	c.(1279-1281)tgG>tgT	p.W427C	KLHL2_ENST00000538127.1_Missense_Mutation_p.W339C|KLHL2_ENST00000421009.2_Missense_Mutation_p.W330C|KLHL2_ENST00000509028.1_3'UTR|KLHL2_ENST00000514860.1_Missense_Mutation_p.W431C|KLHL2_ENST00000506761.1_Missense_Mutation_p.W261C	NM_007246.3	NP_009177.3	O95198	KLHL2_HUMAN	kelch-like family member 2	427					intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity			endometrium(3)|large_intestine(5)|lung(4)|prostate(1)|urinary_tract(1)	14	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)		CTAATGAGTGGTTTCATGTAG	0.383000													40	151					8.69298e-16	1.08735e-15	1	1	0
ACTC1	70	broad.mit.edu	37	15	35085757	35085757	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:35085757C>A	ENST00000290378.4	-	3	798	c.143G>T	c.(142-144)gGt>gTt	p.G48V	RP11-814P5.1_ENST00000503496.1_RNA	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	48					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		CTGACCCATACCCACCATAAC	0.453000													15	32					0.000219431	0.000231259	1	1	0
ZNF680	340252	broad.mit.edu	37	7	63982109	63982109	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:63982109C>A	ENST00000309683.6	-	4	1174	c.1023G>T	c.(1021-1023)aaG>aaT	p.K341N		NM_178558.4	NP_848653.2	Q8NEM1	ZN680_HUMAN	zinc finger protein 680	341					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	27		Lung NSC(55;0.118)|all_lung(88;0.243)				TATGAATTTTCTTATGTTTAG	0.353000													13	44					0.00244969	0.00253853	1	1	0
CAPN6	827	broad.mit.edu	37	X	110494154	110494154	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chrX:110494154C>A	ENST00000324068.1	-	8	1316	c.1149G>T	c.(1147-1149)caG>caT	p.Q383H	CAPN6_ENST00000541758.1_Missense_Mutation_p.Q128H	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	383	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						CCTGGGGATTCTGCAGGAAGG	0.458000													42	102					4.16155e-14	5.12774e-14	1	1	0
CD82	3732	broad.mit.edu	37	11	44640247	44640247	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:44640247G>T	ENST00000227155.4	+	9	948	c.700G>T	c.(700-702)Gtg>Ttg	p.V234L	CD82_ENST00000530931.1_3'UTR|CD82_ENST00000342935.3_Missense_Mutation_p.V209L	NM_002231.3	NP_002222.1	P27701	CD82_HUMAN	CD82 molecule	234						integral to plasma membrane	protein binding			large_intestine(1)|ovary(1)	2						CATCCTCGGCGTGGGCGTGGG	0.627000													9	56					0.000442599	0.000463171	1	1	0
CHAF1A	10036	broad.mit.edu	37	19	4409421	4409421	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:4409421G>A	ENST00000301280.5	+	3	726	c.625G>A	c.(625-627)Gag>Aag	p.E209K		NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	209	Binds to CBX1 chromo shadow domain.				cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGCTGCCCGGAGCTGACGAG	0.587000								Chromatin Structure					12	49					0	0	1	0	0
IPO7	10527	broad.mit.edu	37	11	9431505	9431505	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:9431505C>T	ENST00000379719.3	+	4	493	c.351C>T	c.(349-351)atC>atT	p.I117I		NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	117					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TTCATCACATCATCAAACATG	0.388000													22	64					0	0	1	0	0
UTP15	84135	broad.mit.edu	37	5	72865490	72865490	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:72865490C>G	ENST00000296792.4	+	5	792	c.537C>G	c.(535-537)ctC>ctG	p.L179L	UTP15_ENST00000508491.1_Silent_p.L160L|UTP15_ENST00000543251.1_5'UTR	NM_032175.2	NP_115551.2	Q8TED0	UTP15_HUMAN	UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)	179					rRNA processing	cytoplasm|nucleolus				endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	15		Lung NSC(167;0.00405)|Ovarian(174;0.0129)		OV - Ovarian serous cystadenocarcinoma(47;7.76e-55)		ATCCGGATCTCTTTATAACAG	0.383000													23	73					0	0	1	0	0
BLVRA	644	broad.mit.edu	37	7	43843292	43843292	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:43843292G>C	ENST00000402924.1	+	8	641	c.478G>C	c.(478-480)Gag>Cag	p.E160Q	BLVRA_ENST00000265523.4_Missense_Mutation_p.E160Q	NM_001253823.1	NP_001240752.1	P53004	BIEA_HUMAN	biliverdin reductase A	160				E -> D (in Ref. 2; CAA63635).	heme catabolic process	cytosol	biliverdin reductase activity|zinc ion binding			endometrium(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(2)	12					NADH(DB00157)	GTTGGAAGAAGAGCGGTTTGG	0.592000													72	244					0	0	1	0	0
AARS	16	broad.mit.edu	37	16	70302228	70302228	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:70302228G>A	ENST00000261772.8	-	8	1160	c.1017C>T	c.(1015-1017)ctC>ctT	p.L339L		NM_001605.2	NP_001596.2	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	339					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(3)|cervix(2)|endometrium(5)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	TGCTGGCATTGAGCTTTTCAT	0.502000													28	46					0	0	1	0	0
XKR5	389610	broad.mit.edu	37	8	6679397	6679397	+	RNA	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:6679397G>C	ENST00000518724.1	-	0	951							Q6UX68	XKR5_HUMAN	XK, Kell blood group complex subunit-related family, member 5							integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		TTGCCATGTAGAACGTGACCA	0.532000													4	16					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30703508	30703508	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:30703508C>T	ENST00000256246.2	-	1	3100	c.3026G>A	c.(3025-3027)aGa>aAa	p.R1009K		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1009										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GTGAACTCTTCTATGAGCTTT	0.333000													16	165					0	0	1	0	0
SNHG1	23642	broad.mit.edu	37	11	62620824	62620824	+	RNA	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:62620824C>T	ENST00000364799.1	-	0	43					NR_002560.1																						CTTTCAGTCACACATTGATCA	0.438000													7	86					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25966945	25966945	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:25966945G>C	ENST00000435504.4	-	13	2554	c.2261C>G	c.(2260-2262)tCt>tGt	p.S754C	ASXL2_ENST00000272341.4_Missense_Mutation_p.S494C|ASXL2_ENST00000404843.1_Missense_Mutation_p.S494C|ASXL2_ENST00000336112.4_Missense_Mutation_p.S726C			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	754					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTGGTCTCAGACTGGGGCTG	0.582000													27	118					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587266	55587266	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:55587266C>A	ENST00000333976.4	+	1	181	c.161C>A	c.(160-162)cCc>cAc	p.P54H		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				AAAATCAACCCCAAACTGCAT	0.448000													57	166					1.04682e-39	1.34565e-39	1	1	0
NLGN3	54413	broad.mit.edu	37	X	70387540	70387540	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chrX:70387540T>G	ENST00000374051.3	+	6	1855	c.1533T>G	c.(1531-1533)ttT>ttG	p.F511L	NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000536169.1_Missense_Mutation_p.F491L|NLGN3_ENST00000358741.3_Missense_Mutation_p.F531L	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	531					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					CCTATGTTTTTGGGGTTCCTA	0.502000													7	78					0	0	1	0	0
ZNF98	148198	broad.mit.edu	37	19	22574651	22574651	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:22574651G>T	ENST00000357774.5	-	4	1507	c.1386C>A	c.(1384-1386)taC>taA	p.Y462*		NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				CTTCACATTTGTAGGGTTTCT	0.378000													4	33					0.000602214	0.000629318	1	1	0
RNF151	146310	broad.mit.edu	37	16	2018885	2018885	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:2018885G>A	ENST00000569714.1	+	4	705	c.697G>A	c.(697-699)Gag>Aag	p.E233K	RNF151_ENST00000569210.2_3'UTR|RNF151_ENST00000321392.3_Missense_Mutation_p.E232K	NM_174903.4	NP_777563.2	Q2KHN1	RN151_HUMAN	ring finger protein 151	233					cell differentiation|spermatogenesis	cytoplasm|nucleus	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(1)	2						CGTTGGGGCTGAGGTGGTGGG	0.632000													5	14					0	0	1	0	0
TRPV1	7442	broad.mit.edu	37	17	3475520	3475520	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:3475520C>G	ENST00000174621.6	-	13	2410	c.2121G>C	c.(2119-2121)acG>acC	p.T707T	TRPV1_ENST00000576351.1_Silent_p.T699T|TRPV1_ENST00000571088.1_Silent_p.T709T|SHPK_ENST00000572705.1_Silent_p.T709T|TRPV1_ENST00000399759.3_Silent_p.T709T|TRPV1_ENST00000399756.4_Silent_p.T709T|TRPV1_ENST00000310522.5_Silent_p.T649T|TRPV1_ENST00000425167.2_Silent_p.T720T			Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel, subfamily V, member 1	709	AD (By similarity).				cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	17				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	AGCTCTTCTCCGTGTCCAGGA	0.612000													4	14					0	0	1	0	0
CRAMP1L	57585	broad.mit.edu	37	16	1705288	1705288	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:1705288A>T	ENST00000397412.3	+	9	1205	c.1106A>T	c.(1105-1107)cAt>cTt	p.H369L	LA16c-431H6.6_ENST00000454337.1_3'UTR|CRAMP1L_ENST00000436138.3_Missense_Mutation_p.H366L|CRAMP1L_ENST00000293925.5_Missense_Mutation_p.H369L			Q96RY5	CRML_HUMAN	Crm, cramped-like (Drosophila)	369						nucleus	DNA binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)	22						TGGGCGCTCCATGAGGTGCGA	0.557000													18	50					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171605676	171605676	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:171605676C>T	ENST00000037502.5	-	3	963	c.904G>A	c.(904-906)Gac>Aac	p.D302N		NM_000261.1	NP_000252.1	Q99972	MYOC_HUMAN	myocilin, trabecular meshwork inducible glucocorticoid response	302	Olfactomedin-like.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(1)|urinary_tract(2)	28	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CTGATGAGGTCATACTCAAAA	0.562000													12	114					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181792	140181792	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:140181792T>A	ENST00000522353.2	+	1	1010	c.1010T>A	c.(1009-1011)cTa>cAa	p.L337Q	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.L337Q|PCDHA2_ENST00000520672.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCACAGTTCTACTCGAAATT	0.393000													35	130					0	0	1	0	0
STAC2	342667	broad.mit.edu	37	17	37369772	37369772	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:37369772C>G	ENST00000333461.5	-	9	1350	c.981G>C	c.(979-981)gaG>gaC	p.E327D		NM_198993.3	NP_945344.1	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	327	SH3.				intracellular signal transduction		metal ion binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(2)	17						TCCACCAGTCCTCGTTAGAGT	0.627000													22	63					0	0	1	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745843	77745843	+	Silent	SNP	G	G	A	rs34870411		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:77745843G>A	ENST00000409088.3	-	3	1566	c.1152C>T	c.(1150-1152)atC>atT	p.I384I	LRRTM4_ENST00000409884.1_Silent_p.I384I|LRRTM4_ENST00000409911.1_Silent_p.I385I|LRRTM4_ENST00000409093.1_Silent_p.I384I|LRRTM4_ENST00000409282.1_Silent_p.I385I	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	384						integral to membrane		p.I384I(2)		autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		TAGGTCTAGGGATAATCAGAG	0.488000													8	48					0	0	1	0	0
ZNF304	57343	broad.mit.edu	37	19	57863063	57863063	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:57863063C>T	ENST00000391705.3	+	2	315	c.31C>T	c.(31-33)Cag>Tag	p.Q11*	ZNF304_ENST00000282286.5_Nonsense_Mutation_p.Q11*|ZNF304_ENST00000443917.2_Nonsense_Mutation_p.Q11*|CTC-444N24.13_ENST00000597973.1_RNA|ZNF304_ENST00000598744.1_5'UTR	NM_020657.2	NP_065708.2	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	11					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		GGACCGGGTTCAGGTGAGTGG	0.652000													15	74					0	0	1	0	0
DAOA	267012	broad.mit.edu	37	13	106119491	106119491	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr13:106119491G>T	ENST00000329625.5	+	2	198		c.e2+1		DAOA_ENST00000375936.3_Splice_Site|DAOA-AS1_ENST00000448407.1_RNA			P59103	DAOA_HUMAN	D-amino acid oxidase activator							Golgi apparatus				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|skin(1)	13	Lung NSC(43;0.01)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					AACTCTATTGGTATGTTACTC	0.284000													17	59					1.56452e-12	1.89015e-12	1	1	0
NEURL1	9148	broad.mit.edu	37	10	105330799	105330799	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:105330799C>A	ENST00000369780.4	+	2	665	c.256C>A	c.(256-258)Cag>Aag	p.Q86K	NEURL_ENST00000369777.2_Missense_Mutation_p.Q69K	NM_004210.4	NP_004201.3	O76050	NEU1A_HUMAN		86	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	17				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		TGTCAAGAGGCAGGCCAGCTT	0.682000													23	70					1.22574e-08	1.41857e-08	1	1	0
CALCR	799	broad.mit.edu	37	7	93116258	93116258	+	Silent	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:93116258C>A	ENST00000359558.2	-	4	389	c.90G>T	c.(88-90)ctG>ctT	p.L30L	CALCR_ENST00000394441.1_Silent_p.L12L|CALCR_ENST00000360249.4_Silent_p.L12L|CALCR_ENST00000421592.1_Silent_p.L12L|CALCR_ENST00000426151.1_Silent_p.L12L	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	12					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	GAAGAAGAAACAGTGCCAAGC	0.299000													20	93					2.4624e-09	2.86765e-09	1	1	0
CBWD2	150472	broad.mit.edu	37	2	114220012	114220012	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:114220012C>G	ENST00000433343.2	+	9	807	c.495C>G	c.(493-495)ctC>ctG	p.L165L	CBWD2_ENST00000259199.4_Silent_p.L201L|CBWD2_ENST00000416503.2_Silent_p.L201L			Q8IUF1	CBWD2_HUMAN	COBW domain containing 2	201							ATP binding|protein binding			endometrium(1)|lung(1)	2						ATGCCATTCTCATTAATAAAA	0.333000													9	176					0	0	1	0	0
E2F2	1870	broad.mit.edu	37	1	23847476	23847476	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:23847476C>A	ENST00000361729.2	-	4	1092	c.666G>T	c.(664-666)caG>caT	p.Q222H		NM_004091.3	NP_004082.1	Q14209	E2F2_HUMAN	E2F transcription factor 2	222	Dimerization (Potential).				G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|large_intestine(2)|lung(1)|ovary(3)|skin(2)|urinary_tract(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		GGTCCAAGGCCTGCTCCGTGT	0.572000													10	47					0.00621372	0.00635047	1	1	0
APAF1	317	broad.mit.edu	37	12	99059401	99059401	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:99059401C>G	ENST00000357310.1	+	8	1603	c.1026C>G	c.(1024-1026)ctC>ctG	p.L342L	APAF1_ENST00000550527.1_Silent_p.L331L|APAF1_ENST00000552268.1_Intron|APAF1_ENST00000547045.1_Silent_p.L342L|APAF1_ENST00000333991.1_Intron|APAF1_ENST00000359972.2_Silent_p.L331L|APAF1_ENST00000551964.1_Silent_p.L342L|APAF1_ENST00000339433.3_Silent_p.L342L|APAF1_ENST00000549007.1_Silent_p.L342L	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	342	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	AGTACTACCTCAAACAGCTTC	0.368000													24	124					0	0	1	0	0
NDUFA9	4704	broad.mit.edu	37	12	4778906	4778906	+	Splice_Site	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:4778906G>T	ENST00000266544.5	+	8	743		c.e8-1		RP11-234B24.6_ENST00000544741.2_Intron	NM_005002.4	NP_004993.1	Q16795	NDUA9_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa						mitochondrial electron transport, NADH to ubiquinone|sodium ion transport	mitochondrial matrix|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity|protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21					NADH(DB00157)	ATTTCTTACAGGTCGTAGATG	0.353000													24	80					1.1804e-14	1.46416e-14	1	1	0
RP1L1	94137	broad.mit.edu	37	8	10469814	10469814	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:10469814G>T	ENST00000382483.3	-	4	2017	c.1794C>A	c.(1792-1794)acC>acA	p.T598T		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	598					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TGGCCTGCTCGGTGCCCTGTC	0.637000													37	84					1.90571e-15	2.37176e-15	1	1	0
KIRREL2	84063	broad.mit.edu	37	19	36348266	36348266	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:36348266G>T	ENST00000360202.5	+	2	279	c.81G>T	c.(79-81)ctG>ctT	p.L27L	KIRREL2_ENST00000347900.6_Intron|KIRREL2_ENST00000586102.2_Silent_p.L27L|KIRREL2_ENST00000262625.7_Silent_p.L27L|NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000592409.1_Silent_p.L27L	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	27	Ig-like C2-type 1.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCATTTCCTGCAACAGCCAG	0.657000													21	94					2.21704e-12	2.66546e-12	1	1	0
C8orf86	389649	broad.mit.edu	37	8	38385958	38385958	+	Silent	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:38385958T>A	ENST00000358138.1	-	1	222	c.198A>T	c.(196-198)acA>acT	p.T66T	C8orf86_ENST00000437935.2_Silent_p.T66T	NM_207412.1	NP_997295.1	Q6ZUL3	CH086_HUMAN	chromosome 8 open reading frame 86	66										breast(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	5						TGGAACTGCCTGTTCTTTGTC	0.557000													31	89					0	0	1	0	0
IER5L	389792	broad.mit.edu	37	9	131939601	131939601	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:131939601G>C	ENST00000372491.2	-	1	939	c.731C>G	c.(730-732)tCg>tGg	p.S244W	RP11-247A12.8_ENST00000599172.2_RNA|RP11-247A12.2_ENST00000372490.3_RNA	NM_203434.2	NP_982258.2	Q5T953	IER5L_HUMAN	immediate early response 5-like	244													Ovarian(14;0.0448)|Medulloblastoma(224;0.235)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)		GCCGAAGTCCGAAGGGGTAGG	0.716000													4	52					0	0	1	0	0
PSD2	84249	broad.mit.edu	37	5	139193057	139193057	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:139193057C>T	ENST00000274710.3	+	3	740	c.535C>T	c.(535-537)Ccc>Tcc	p.P179S		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	179					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCGAGGCCCCCCTCACACC	0.677000													5	73					0	0	1	0	0
LINC00303	284573	broad.mit.edu	37	1	204006311	204006311	+	RNA	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:204006311T>A	ENST00000367207.3	-	0	709																											GCCTTGCCCCTGCTGGCTGAG	0.517000													13	4					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9404407	9404407	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:9404407G>C	ENST00000378501.2	+	24	2311	c.2296G>C	c.(2296-2298)Gac>Cac	p.D766H	PLCB4_ENST00000378473.3_Missense_Mutation_p.D778H|PLCB4_ENST00000334005.3_Missense_Mutation_p.D766H|PLCB4_ENST00000278655.4_Missense_Mutation_p.D766H|PLCB4_ENST00000414679.2_Missense_Mutation_p.D778H|PLCB4_ENST00000378493.1_Missense_Mutation_p.D766H|PLCB4_ENST00000492632.1_3'UTR	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	766	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						GATCCTGCCGGACCTGGCTGT	0.498000													4	37					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64666299	64666299	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:64666299C>T	ENST00000421419.2	-	32	4600	c.4486G>A	c.(4486-4488)Gag>Aag	p.E1496K	ATG2A_ENST00000377264.3_Missense_Mutation_p.E1494K			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1494							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						GGGTACACCTCGTGCTGGAAG	0.657000													3	32					0	0	1	0	0
C16orf86	388284	broad.mit.edu	37	16	67702293	67702293	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:67702293C>T	ENST00000403458.4	+	4	899	c.744C>T	c.(742-744)ctC>ctT	p.L248L		NM_001012984.2	NP_001013002.2	Q6ZW13	CP086_HUMAN	chromosome 16 open reading frame 86	248										endometrium(2)|lung(4)	6		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		GCCCAGGCCTCGCTTTGCCCT	0.692000											OREG0023886	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	18					0	0	1	0	0
UBXN10	127733	broad.mit.edu	37	1	20517387	20517387	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:20517387C>G	ENST00000375099.3	+	2	417	c.333C>G	c.(331-333)ctC>ctG	p.L111L		NM_152376.3	NP_689589.1	Q96LJ8	UBX10_HUMAN	UBX domain protein 10	111										endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(2)|skin(2)	14						CCTCTTCTCTCAATAAGTATC	0.517000													17	61					0	0	1	0	0
ZCCHC9	84240	broad.mit.edu	37	5	80604808	80604808	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:80604808G>A	ENST00000254037.2	+	3	3734	c.579G>A	c.(577-579)ggG>ggA	p.G193G	ZCCHC9_ENST00000407610.3_Silent_p.G193G|ZCCHC9_ENST00000380199.5_Silent_p.G193G|ZCCHC9_ENST00000506458.1_3'UTR|ZCCHC9_ENST00000438268.2_Silent_p.G193G			Q8N567	ZCHC9_HUMAN	zinc finger, CCHC domain containing 9	193							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)	13		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;8.18e-45)|Epithelial(54;2.72e-39)|all cancers(79;7.33e-34)		GAGAAATGGGGCACCTGTCTA	0.388000													16	75					0	0	1	0	0
MKNK1	8569	broad.mit.edu	37	1	47040664	47040664	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:47040664C>T	ENST00000371946.4	-	6	506	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	MKNK1_ENST00000341183.5_Missense_Mutation_p.E115K|MKNK1_ENST00000428112.2_Missense_Mutation_p.E115K|MKNK1_ENST00000545730.1_Missense_Mutation_p.E115K|MKNK1_ENST00000371944.4_Intron|MKNK1_ENST00000371945.4_Missense_Mutation_p.E115K	NM_003684.5	NP_003675.2	Q9BUB5	MKNK1_HUMAN	MAP kinase interacting serine/threonine kinase 1	115	Protein kinase.				intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	13	Acute lymphoblastic leukemia(166;0.155)					GTGTCATCTTCAAAGAACTCA	0.388000													18	45					0	0	1	0	0
PIGG	54872	broad.mit.edu	37	4	501316	501316	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:501316G>A	ENST00000453061.2	+	4	799	c.693G>A	c.(691-693)ctG>ctA	p.L231L	PIGG_ENST00000383028.4_Intron|PIGG_ENST00000536264.1_Silent_p.L109L|PIGG_ENST00000503111.1_Silent_p.L142L|PIGG_ENST00000504346.1_Silent_p.L142L|PIGG_ENST00000509768.1_Silent_p.L142L|PIGG_ENST00000310340.5_Silent_p.L231L|PIGG_ENST00000296306.7_Silent_p.L142L	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	231					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						ACAGCCCCCTGATTGGGCAGA	0.522000													17	57					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28651775	28651775	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr18:28651775G>A	ENST00000280904.6	-	13	2364	c.1921C>T	c.(1921-1923)Cct>Tct	p.P641S	DSC2_ENST00000251081.6_Missense_Mutation_p.P641S	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	641	Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CCAAATGGAGGATCATTCTGA	0.353000													6	55					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132534868	132534868	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:132534868G>C	ENST00000265342.7	-	16	2697	c.2448C>G	c.(2446-2448)atC>atG	p.I816M	CTB-49A3.2_ENST00000509051.1_RNA	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	816						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GTCTCCCATTGATGAGGAACA	0.597000													7	30					0	0	1	0	0
ADCY8	114	broad.mit.edu	37	8	131896840	131896840	+	Silent	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:131896840C>A	ENST00000286355.5	-	8	4171	c.2079G>T	c.(2077-2079)ctG>ctT	p.L693L	ADCY8_ENST00000377928.3_Silent_p.L693L	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	693					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTTTAAACATCAGTGAGAATG	0.458000										HNSCC(32;0.087)			25	125					1.96895e-08	2.26109e-08	1	1	0
CACNA2D4	93589	broad.mit.edu	37	12	1967762	1967762	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:1967762C>T	ENST00000382722.5	-	20	2351	c.1989G>A	c.(1987-1989)ggG>ggA	p.G663G	CACNA2D4_ENST00000588077.1_Silent_p.G599G|CACNA2D4_ENST00000586184.1_Silent_p.G663G|CACNA2D4_ENST00000587995.1_Silent_p.G638G|CACNA2D4_ENST00000585732.1_Silent_p.G524G|CACNA2D4_ENST00000539048.2_5'UTR|CACNA2D4_ENST00000585708.1_Silent_p.G599G	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	663						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CAGACGTGTTCCCCAGAAGGA	0.587000													11	38					0	0	1	0	0
OR4D1	26689	broad.mit.edu	37	17	56232727	56232727	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:56232727C>G	ENST00000268912.5	+	1	234	c.213C>G	c.(211-213)ctC>ctG	p.L71L		NM_012374.1	NP_036506.1	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D, member 1	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13						TCATAGACCTCTGCTATTCCA	0.507000													48	134					0	0	1	0	0
JMJD1C	221037	broad.mit.edu	37	10	64973838	64973838	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:64973838C>T	ENST00000399262.2	-	8	2307	c.2089G>A	c.(2089-2091)Gaa>Aaa	p.E697K	JMJD1C_ENST00000402544.1_Missense_Mutation_p.E478K|JMJD1C_ENST00000399251.1_Missense_Mutation_p.E478K|JMJD1C_ENST00000542921.1_Missense_Mutation_p.E515K	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	697					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTTGTAGTTTCTAATGTACTG	0.368000													21	92					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144912139	144912139	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:144912139C>T	ENST00000529945.1	-	11	3064	c.2625G>A	c.(2623-2625)caG>caA	p.Q875Q	PDE4DIP_ENST00000313382.9_Silent_p.Q778Q|PDE4DIP_ENST00000369351.3_Silent_p.Q712Q|PDE4DIP_ENST00000369349.3_Silent_p.Q712Q|PDE4DIP_ENST00000369356.4_Silent_p.Q712Q|PDE4DIP_ENST00000479408.2_Silent_p.Q499Q|PDE4DIP_ENST00000313431.9_Silent_p.Q875Q|PDE4DIP_ENST00000369359.4_Silent_p.Q849Q|PDE4DIP_ENST00000530740.1_Silent_p.Q849Q|PDE4DIP_ENST00000369354.3_Silent_p.Q712Q			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	712					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTTGATCAGTCTGTTTTCCAA	0.403000			T	PDGFRB	MPD								11	147					0	0	1	0	0
LARP4	113251	broad.mit.edu	37	12	50869400	50869400	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:50869400C>A	ENST00000398473.2	+	16	2040	c.1928C>A	c.(1927-1929)tCc>tAc	p.S643Y	LARP4_ENST00000429001.3_Missense_Mutation_p.S649Y|LARP4_ENST00000293618.8_Missense_Mutation_p.S572Y|LARP4_ENST00000518444.1_Missense_Mutation_p.S642Y|LARP4_ENST00000347328.5_Missense_Mutation_p.S572Y	NM_052879.4|NM_199188.2	NP_443111.4|NP_954658.2	Q71RC2	LARP4_HUMAN	La ribonucleoprotein domain family, member 4	643							nucleotide binding|RNA binding			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						GAACTTCGCTCCAATGTGGTG	0.478000													25	229					3.08376e-08	3.52498e-08	1	1	0
ZNF570	148268	broad.mit.edu	37	19	37975989	37975989	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:37975989C>T	ENST00000330173.1	+	5	1994	c.1465C>T	c.(1465-1467)Cag>Tag	p.Q489*	ZNF570_ENST00000388801.3_Nonsense_Mutation_p.Q286*|ZNF570_ENST00000586475.1_Nonsense_Mutation_p.Q545*	NM_144694.1	NP_653295.1	Q96NI8	ZN570_HUMAN	zinc finger protein 570	489					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(1)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGCCCAACATCAGAGAATTCA	0.433000													10	87					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133920472	133920472	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:133920472C>T	ENST00000220616.4	+	18	3929	c.3889C>T	c.(3889-3891)Cag>Tag	p.Q1297*	TG_ENST00000377869.1_Nonsense_Mutation_p.Q1297*	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1297					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGGGCACTTTCAGCTCCAGCT	0.562000													10	58					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75557778	75557778	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:75557778C>G	ENST00000604729.1	+	19	4199	c.3902C>G	c.(3901-3903)tCt>tGt	p.S1301C	ZSWIM8_ENST00000603114.1_Missense_Mutation_p.S1263C|ZSWIM8_ENST00000604524.1_Missense_Mutation_p.S1296C|NDST2_ENST00000456638.1_5'UTR|ZSWIM8_ENST00000398706.2_Missense_Mutation_p.S1301C|ZSWIM8_ENST00000605216.1_Missense_Mutation_p.S1296C					zinc finger, SWIM-type containing 8																		AACTTTGTTTCTCCCAACTGG	0.527000													5	62					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46314535	46314535	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:46314535C>T	ENST00000510861.1	-	5	627	c.454G>A	c.(454-456)Ggg>Agg	p.G152R	GABRA2_ENST00000507069.1_Missense_Mutation_p.G152R|GABRA2_ENST00000514090.1_Missense_Mutation_p.G152R|GABRA2_ENST00000515082.1_Missense_Mutation_p.G152R|GABRA2_ENST00000540012.1_Missense_Mutation_p.G97R|GABRA2_ENST00000381620.4_Missense_Mutation_p.G152R|GABRA2_ENST00000356504.1_Missense_Mutation_p.G152R			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	152					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGCAGAGTCCCATCATCCTGA	0.348000													7	113					0	0	1	0	0
NPM1	4869	broad.mit.edu	37	5	170827897	170827897	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:170827897G>A	ENST00000296930.5	+	8	938	c.637G>A	c.(637-639)Gac>Aac	p.D213N	NPM1_ENST00000351986.6_Intron|NPM1_ENST00000517671.1_Missense_Mutation_p.D213N|NPM1_ENST00000393820.2_Missense_Mutation_p.D213N	NM_002520.6	NP_002511.1	P06748	NPM_HUMAN	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	213				D -> P (in Ref. 21; AAA36473/AAA36474).	anti-apoptosis|cell aging|CenH3-containing nucleosome assembly at centromere|centrosome cycle|DNA repair|interspecies interaction between organisms|intracellular protein transport|negative regulation of cell proliferation|negative regulation of centrosome duplication|nucleocytoplasmic transport|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|regulation of endodeoxyribonuclease activity|regulation of endoribonuclease activity|ribosome assembly|signal transduction	nucleolus|nucleoplasm|ribonucleoprotein complex|spindle pole centrosome	histone binding|NF-kappaB binding|protein binding|protein heterodimerization activity|protein homodimerization activity|ribosomal large subunit binding|ribosomal small subunit binding|RNA binding|Tat protein binding|transcription coactivator activity|unfolded protein binding		NPM1/ALK(632)	central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4261)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	4269	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAATGGAAAAGACTCAAAACC	0.383000			"""T, F """	"""ALK, RARA, MLF1"""	"""NHL, APL, AML"""								6	67					0	0	1	0	0
MMRN1	22915	broad.mit.edu	37	4	90856201	90856201	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:90856201T>C	ENST00000394980.1	+	7	1689	c.1370T>C	c.(1369-1371)gTg>gCg	p.V457A	MMRN1_ENST00000264790.2_Missense_Mutation_p.V457A|MMRN1_ENST00000508372.1_Missense_Mutation_p.V199A|MMRN1_ENST00000394981.1_Intron			Q13201	MMRN1_HUMAN	multimerin 1	457					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		ACTGATATAGTGGAACTAAGG	0.368000													28	97					0	0	1	0	0
PRDX6	9588	broad.mit.edu	37	1	173454505	173454505	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:173454505C>G	ENST00000340385.5	+	3	390	c.258C>G	c.(256-258)atC>atG	p.I86M	PRDX6_ENST00000470017.1_3'UTR	NM_004905.2	NP_004896.1	P30041	PRDX6_HUMAN	peroxiredoxin 6	86	Thioredoxin.				cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	12						TTCAGGATATCAATGCTTACA	0.438000													15	107					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185703998	185703998	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:185703998G>C	ENST00000271588.4	+	1	316	c.87G>C	c.(85-87)gaG>gaC	p.E29D	HMCN1_ENST00000367492.2_Missense_Mutation_p.E29D	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	29					response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CCCAGTCAGAGATCAGAGCTG	0.448000													33	246					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558401	113558401	+	Silent	SNP	T	T	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:113558401T>C	ENST00000284601.3	-	1	719	c.651A>G	c.(649-651)acA>acG	p.T217T		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	217	CBM21.				glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TTGACCAAAATGTACCAACAG	0.348000													29	99					0	0	1	0	0
ROGDI	79641	broad.mit.edu	37	16	4848120	4848120	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:4848120G>T	ENST00000322048.7	-	8	975	c.597C>A	c.(595-597)ctC>ctA	p.L199L	ROGDI_ENST00000586336.1_5'UTR	NM_024589.2	NP_078865.1	Q9GZN7	ROGDI_HUMAN	rogdi homolog (Drosophila)	199						intracellular				endometrium(2)|lung(1)|ovary(1)|skin(1)	5						CCGTGAGGCAGAGCTTGTTGA	0.662000													9	33					0.000442599	0.000463171	1	1	0
ANKFY1	51479	broad.mit.edu	37	17	4080482	4080482	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:4080482G>C	ENST00000341657.4	-	19	2749	c.2714C>G	c.(2713-2715)tCc>tGc	p.S905C	ANKFY1_ENST00000570535.1_Missense_Mutation_p.S947C|CYB5D2_ENST00000573984.1_Intron|ANKFY1_ENST00000574367.1_Missense_Mutation_p.S906C	NM_016376.3	NP_057460.3	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	905				S -> P (in Ref. 1; BAA90300).		endosome membrane	metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|liver(1)|lung(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32						GGTCAACTTGGAGGCATCCTG	0.448000													24	68					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82841369	82841369	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:82841369C>A	ENST00000265077.3	+	9	9844	c.9279C>A	c.(9277-9279)tgC>tgA	p.C3093*	VCAN_ENST00000502527.2_Nonsense_Mutation_p.C352*|VCAN_ENST00000343200.5_Nonsense_Mutation_p.C2106*|VCAN_ENST00000342785.4_Nonsense_Mutation_p.C1339*|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000512590.2_Nonsense_Mutation_p.C1291*|VCAN-AS1_ENST00000512090.1_RNA|VCAN-AS1_ENST00000513899.1_RNA	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	3093	EGF-like 1.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CTGATCGCTGCAAAATGAACC	0.463000													44	198					6.1207e-33	7.85436e-33	1	1	0
CCDC73	493860	broad.mit.edu	37	11	32635205	32635205	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:32635205C>G	ENST00000335185.5	-	16	2702	c.2659G>C	c.(2659-2661)Gat>Cat	p.D887H		NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	887										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					GTTGAAAGATCAAAGGTTGAC	0.378000													53	186					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152187603	152187603	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:152187603G>A	ENST00000368801.2	-	3	6577	c.6502C>T	c.(6502-6504)Cag>Tag	p.Q2168*	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	2168					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCGAAGACTGACGGGAGCCA	0.622000													30	896					0	0	1	0	0
GALNT5	11227	broad.mit.edu	37	2	158114939	158114939	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:158114939G>A	ENST00000259056.4	+	1	830	c.345G>A	c.(343-345)caG>caA	p.Q115Q		NM_014568.1	NP_055383.1	Q7Z7M9	GALT5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)	115					glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(4)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	56						GAAAAATGCAGAATGCCCTGG	0.532000													6	101					0	0	1	0	0
OR6A2	8590	broad.mit.edu	37	11	6816569	6816569	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:6816569G>T	ENST00000332601.3	-	1	559	c.371C>A	c.(370-372)gCc>gAc	p.A124D		NM_003696.2	NP_003687.2	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A, member 2	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(4)|pancreas(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	29		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCGATCATAGGCCATAACAGC	0.532000													14	56					2.61681e-11	3.1059e-11	1	1	0
FNBP1	23048	broad.mit.edu	37	9	132671200	132671200	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:132671200T>A	ENST00000420781.1	-	12	1455	c.1237A>T	c.(1237-1239)Aat>Tat	p.N413Y	FNBP1_ENST00000478129.1_5'UTR|FNBP1_ENST00000446176.2_Missense_Mutation_p.N422Y|FNBP1_ENST00000443566.2_Missense_Mutation_p.N50Y|FNBP1_ENST00000355681.3_Missense_Mutation_p.N393Y			Q96RU3	FNBP1_HUMAN	formin binding protein 1	422	Interaction with RND2 (By similarity).|Required for self-association and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding						Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		ATTTCTTTATTTAACTCATCG	0.423000			T	MLL	AML								9	20					0	0	1	0	0
CXCL10	3627	broad.mit.edu	37	4	76943590	76943590	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:76943590C>G	ENST00000306602.1	-	3	272	c.207G>C	c.(205-207)aaG>aaC	p.K69N	ART3_ENST00000341029.5_Intron	NM_001565.3	NP_001556.2	P02778	CXL10_HUMAN	chemokine (C-X-C motif) ligand 10	69					blood circulation|cell surface receptor linked signaling pathway|cell-cell signaling|chemotaxis|inflammatory response|muscle organ development|positive regulation of cell proliferation	extracellular space	cAMP-dependent protein kinase regulator activity|chemokine activity			kidney(1)|large_intestine(1)|lung(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCTTCTCACCCTTCTTTTTCA	0.383000													26	86					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55220779	55220779	+	RNA	SNP	C	C	T	rs28394351	by1000genomes	TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:55220779C>T	ENST00000413439.1	+	0	808																											TGATGTGGGACGCGTGAGCCC	0.602000													8	31					0	0	1	0	0
ELMO1	9844	broad.mit.edu	37	7	36934523	36934523	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:36934523C>T	ENST00000310758.4	-	17	2184	c.1537G>A	c.(1537-1539)Gag>Aag	p.E513K	ELMO1_ENST00000396040.2_Missense_Mutation_p.E33K|ELMO1_ENST00000396045.3_Missense_Mutation_p.E33K|ELMO1_ENST00000341056.3_Missense_Mutation_p.E215K|ELMO1_ENST00000448602.1_Missense_Mutation_p.E513K|ELMO1_ENST00000442504.1_Missense_Mutation_p.E513K	NM_001206480.1|NM_014800.10	NP_001193409.1|NP_055615.8	Q92556	ELMO1_HUMAN	engulfment and cell motility 1	513					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(28)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	58						TTCAGGATCTCAGTGTAGCTC	0.488000													9	82					0	0	1	0	0
HERC4	26091	broad.mit.edu	37	10	69749992	69749992	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:69749992C>G	ENST00000395198.3	-	14	1856	c.1609G>C	c.(1609-1611)Gaa>Caa	p.E537Q	HERC4_ENST00000395187.2_3'UTR|HERC4_ENST00000277817.6_Missense_Mutation_p.E427Q|HERC4_ENST00000373700.4_Missense_Mutation_p.E537Q|HERC4_ENST00000412272.2_Missense_Mutation_p.E537Q	NM_022079.2	NP_071362.1	Q5GLZ8	HERC4_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 4	537					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	27						GGTGCCTTTTCTAGGTTCACA	0.338000													11	71					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	132937929	132937929	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:132937929C>G	ENST00000253861.4	+	1	101	c.72C>G	c.(70-72)ctC>ctG	p.L24L	EXOC4_ENST00000393161.2_Silent_p.L24L	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	24					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				CGGGGCTGCTCATCTCTGTGA	0.627000													4	72					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183201894	183201894	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:183201894C>G	ENST00000264144.4	+	14	2187	c.2122C>G	c.(2122-2124)Ctg>Gtg	p.L708V	LAMC2_ENST00000493293.1_Missense_Mutation_p.L708V	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	708	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						AGTTCGGGCTCTGGGAAGTCA	0.542000													26	170					0	0	1	0	0
CEP78	84131	broad.mit.edu	37	9	80851438	80851438	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:80851438C>G	ENST00000424347.2	+	1	461	c.172C>G	c.(172-174)Ctg>Gtg	p.L58V	CEP78_ENST00000415759.2_Missense_Mutation_p.L58V|CEP78_ENST00000277082.5_Missense_Mutation_p.L58V|CEP78_ENST00000376597.4_Missense_Mutation_p.L58V|CEP78_ENST00000376598.2_Missense_Mutation_p.L58V			Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa	58					G2/M transition of mitotic cell cycle	centrosome|cytosol				breast(1)|cervix(1)|endometrium(5)|large_intestine(7)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	21						CTGGGCGCCTCTGCTGAGCAC	0.652000													4	13					0	0	1	0	0
BTN3A1	11119	broad.mit.edu	37	6	26413540	26413540	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:26413540G>A	ENST00000289361.6	+	10	1530	c.1162G>A	c.(1162-1164)Gag>Aag	p.E388K	BTN3A1_ENST00000414912.2_Missense_Mutation_p.E336K	NM_001145008.1|NM_001145009.1|NM_007048.5	NP_001138480.1|NP_001138481.1|NP_008979.3	O00481	BT3A1_HUMAN	butyrophilin, subfamily 3, member A1	388	B30.2/SPRY.				lipid metabolic process	integral to membrane				breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	28						TCTCGGCTGTGAGAGCTTCAT	0.512000													26	155					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7703937	7703937	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:7703937C>A	ENST00000340209.4	+	9	1190	c.893C>A	c.(892-894)cCg>cAg	p.P298Q	RBFOX1_ENST00000355637.4_Missense_Mutation_p.P313Q|RBFOX1_ENST00000552089.1_Missense_Mutation_p.P310Q|RBFOX1_ENST00000547338.1_Missense_Mutation_p.P293Q|RBFOX1_ENST00000422070.4_Missense_Mutation_p.P336Q|RBFOX1_ENST00000550418.1_Missense_Mutation_p.P293Q|RBFOX1_ENST00000436368.2_Missense_Mutation_p.P313Q|RBFOX1_ENST00000311745.5_Missense_Mutation_p.P313Q|RBFOX1_ENST00000553186.1_Missense_Mutation_p.P266Q|RBFOX1_ENST00000535565.2_Missense_Mutation_p.P250Q|RBFOX1_ENST00000547372.1_Missense_Mutation_p.P336Q			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	293					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						cccccgATCCCGGCCTACGGC	0.741000													9	16					0.00448238	0.00461275	1	1	0
SPTA1	6708	broad.mit.edu	37	1	158627389	158627389	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:158627389G>T	ENST00000368148.3	-	19	2863	c.2683C>A	c.(2683-2685)Ctt>Att	p.L895I	SPTA1_ENST00000368147.3_Missense_Mutation_p.L895I	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	895					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TTGGCTTCAAGATCATTTTGT	0.468000													41	259					1.15505e-17	1.44966e-17	1	1	0
GRIN3A	116443	broad.mit.edu	37	9	104449474	104449474	+	Silent	SNP	A	A	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:104449474A>T	ENST00000361820.3	-	2	1308	c.708T>A	c.(706-708)ctT>ctA	p.L236L		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	236					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GTTGTAGGTGAAGGGGATTCT	0.353000													25	89					0	0	1	0	0
NCAM2	4685	broad.mit.edu	37	21	22906869	22906869	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr21:22906869C>A	ENST00000400546.1	+	17	2543	c.2294C>A	c.(2293-2295)tCa>tAa	p.S765*	NCAM2_ENST00000284894.7_Nonsense_Mutation_p.S623*	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	765					neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		AAAGATGGATCAAAAGAACCA	0.363000													12	52					5.50884e-06	5.94059e-06	1	1	0
LOC643733	643733	broad.mit.edu	37	11	104776315	104776315	+	RNA	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:104776315C>T	ENST00000532510.1	-	0	3117																											ATGCCTTGGGCTATGACCTTC	0.383000													7	39					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41790583	41790583	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:41790583C>T	ENST00000396930.3	-	18	5698	c.5155G>A	c.(5155-5157)Gag>Aag	p.E1719K	KAT6A_ENST00000406337.1_Missense_Mutation_p.E1719K|KAT6A_ENST00000265713.2_Missense_Mutation_p.E1719K	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1719					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TCTGGTATCTCCATGATCATA	0.547000													7	106					0	0	1	0	0
XKR8	55113	broad.mit.edu	37	1	28290149	28290149	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:28290149G>C	ENST00000373884.5	+	2	1043	c.435G>C	c.(433-435)caG>caC	p.Q145H	XKR8_ENST00000481387.1_3'UTR	NM_018053.2	NP_060523.2	Q9H6D3	XKR8_HUMAN	XK, Kell blood group complex subunit-related family, member 8	145						integral to membrane				endometrium(1)|large_intestine(2)|lung(1)	4		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;4.72e-24)|Colorectal(126;1.52e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00572)|READ - Rectum adenocarcinoma(331;0.0526)		CGGCACCACAGCTCACGCTGG	0.627000													4	12					0	0	1	0	0
APOBR	55911	broad.mit.edu	37	16	28508385	28508385	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:28508385G>C	ENST00000564831.1	+	2	2056	c.2023G>C	c.(2023-2025)Gag>Cag	p.E675Q	APOBR_ENST00000328423.5_Missense_Mutation_p.E666Q|APOBR_ENST00000431282.1_Missense_Mutation_p.E666Q	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	666	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						AGAAGTCCCAGAGGCAGGCGG	0.647000													3	13					0	0	1	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75929290	75929290	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:75929290G>A	ENST00000262207.4	+	9	1406	c.938G>A	c.(937-939)tGt>tAt	p.C313Y	CRISPLD1_ENST00000523524.1_Missense_Mutation_p.C125Y|CRISPLD1_ENST00000517786.1_Missense_Mutation_p.C127Y	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	313	LCCL 1.					extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			AGGTACGAATGTCCTGCTGGC	0.274000													12	36					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	210970944	210970944	+	Silent	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:210970944G>C	ENST00000367007.4	-	9	1909	c.1740C>G	c.(1738-1740)ctC>ctG	p.L580L	KCNH1_ENST00000271751.4_Silent_p.L607L	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	607					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CATGGTAGATGAGGTCCCCTG	0.602000													17	132					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84267185	84267185	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:84267185G>A	ENST00000376499.3	-	6	1380	c.316C>T	c.(316-318)Cag>Tag	p.Q106*	TLE1_ENST00000376463.1_Nonsense_Mutation_p.Q50*|TLE1_ENST00000376472.1_5'UTR	NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	106	Gln-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						TCAACAGCCTGGGCCACCTGT	0.458000													37	129					0	0	1	0	0
HDGF	3068	broad.mit.edu	37	1	156721201	156721201	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:156721201C>T	ENST00000357325.5	-	1	335	c.21G>A	c.(19-21)caG>caA	p.Q7Q	HDGF_ENST00000537739.1_Silent_p.Q7Q|HDGF_ENST00000465180.1_Intron|HDGF_ENST00000368209.5_Intron|PRCC_ENST00000491853.1_Intron|HDGF_ENST00000368206.5_Intron	NM_004494.2	NP_004485.1	P51858	HDGF_HUMAN	hepatoma-derived growth factor	7					cell proliferation|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	DNA binding|growth factor activity|heparin binding|nucleotide binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9	all_hematologic(923;0.088)|Hepatocellular(266;0.158)	Breast(1374;0.198)		Colorectal(1306;0.018)		TGTACTCCTTCTGCCGGTTGG	0.741000													7	40					0	0	1	0	0
PTPMT1	114971	broad.mit.edu	37	11	47593084	47593084	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:47593084A>T	ENST00000326656.8	+	3	341	c.317A>T	c.(316-318)cAc>cTc	p.H106L	PTPMT1_ENST00000426530.2_Silent_p.P142P|PTPMT1_ENST00000326674.9_Missense_Mutation_p.H170L|PTPMT1_ENST00000534775.1_3'UTR|NDUFS3_ENST00000533507.1_3'UTR|PTPMT1_ENST00000527079.2_3'UTR			Q8WUK0	PTPM1_HUMAN	protein tyrosine phosphatase, mitochondrial 1	170					inositol phosphate dephosphorylation	mitochondrial inner membrane	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	6						TCATACATCCACATCAGGCCT	0.478000													25	79					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38936185	38936185	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:38936185C>G	ENST00000302328.3	-	15	2872	c.2674G>C	c.(2674-2676)Gag>Cag	p.E892Q	SCN11A_ENST00000444237.2_Missense_Mutation_p.E892Q|SCN11A_ENST00000450244.1_Missense_Mutation_p.E892Q|SCN11A_ENST00000456224.3_Missense_Mutation_p.E892Q	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	892					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TCCTGGGTCTCTGAGCCCCTT	0.522000													24	106					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113702250	113702250	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:113702250C>A	ENST00000297405.5	-	14	2246	c.2002G>T	c.(2002-2004)Ggt>Tgt	p.G668C	CSMD3_ENST00000455883.2_Missense_Mutation_p.G564C|CSMD3_ENST00000343508.3_Missense_Mutation_p.G628C|CSMD3_ENST00000352409.3_Missense_Mutation_p.G668C	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	668	Sushi 3.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAGGGTGTACCAGGATCACCA	0.368000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			28	160					4.87955e-14	5.99258e-14	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25310227	25310227	+	RNA	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:25310227G>A	ENST00000549804.2	+	0	538				SNORD116-6_ENST00000384711.1_RNA|SNHG14_ENST00000551077.1_RNA																							TGAACAAAATGAGTGAAAACT	0.463000													13	219					0	0	1	0	0
ELF2	1998	broad.mit.edu	37	4	139981552	139981552	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:139981552G>A	ENST00000394235.2	-	9	1549	c.1047C>T	c.(1045-1047)atC>atT	p.I349I	ELF2_ENST00000358635.3_Silent_p.I301I|ELF2_ENST00000379550.1_Silent_p.I361I|ELF2_ENST00000515489.1_5'UTR|ELF2_ENST00000379549.2_Silent_p.I272I|ELF2_ENST00000265495.4_Silent_p.I349I|ELF2_ENST00000510408.1_Silent_p.I289I	NM_001276458.1	NP_001263387.1	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription factor)	361					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	19	all_hematologic(180;0.162)					CAGGGGAAGTGATATTCACAA	0.473000													18	42					0	0	1	0	0
ARID4B	51742	broad.mit.edu	37	1	235346019	235346019	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:235346019C>T	ENST00000264183.3	-	20	2712	c.2215G>A	c.(2215-2217)Gat>Aat	p.D739N	ARID4B_ENST00000349213.3_Missense_Mutation_p.D653N|ARID4B_ENST00000366603.2_Missense_Mutation_p.D739N	NM_016374.5	NP_057458.4	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B (RBP1-like)	739					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			GTCAAATGATCAATCTTAGAT	0.363000													13	105					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380629	56380629	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:56380629G>A	ENST00000526538.1	-	1	349	c.350C>T	c.(349-351)tCa>tTa	p.S117L		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						CAATGCCATTGAAGCAAGGAT	0.463000													8	88					0	0	1	0	0
PLAT	5327	broad.mit.edu	37	8	42037474	42037474	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:42037474C>A	ENST00000220809.4	-	12	1589	c.1333G>T	c.(1333-1335)Gag>Tag	p.E445*	PLAT_ENST00000519510.1_Nonsense_Mutation_p.E382*|PLAT_ENST00000429710.2_Nonsense_Mutation_p.E319*|PLAT_ENST00000429089.2_Nonsense_Mutation_p.E445*|PLAT_ENST00000352041.3_Nonsense_Mutation_p.E399*|PLAT_ENST00000270189.6_Silent_p.V275V|PLAT_ENST00000524009.1_Nonsense_Mutation_p.E356*	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	445	Peptidase S1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CCGGAGAGCTCACACTCCGTC	0.657000													6	18					0.00198382	0.00205863	1	1	0
LAMA1	284217	broad.mit.edu	37	18	6964673	6964673	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr18:6964673G>A	ENST00000389658.3	-	51	7418	c.7325C>T	c.(7324-7326)tCa>tTa	p.S2442L		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2442	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TACAACTCTTGACCTTGGTAA	0.448000													5	106					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171549011	171549011	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:171549011G>A	ENST00000367742.3	+	28	7559	c.7317G>A	c.(7315-7317)ctG>ctA	p.L2439L	PRRC2C_ENST00000392078.3_Silent_p.L2439L|PRRC2C_ENST00000426496.2_Silent_p.L2372L|PRRC2C_ENST00000338920.4_Silent_p.L2437L			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	2437	Gln-rich.						protein C-terminus binding										ATGCACCACTGCAAGGGCAGC	0.443000													12	60					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120629782	120629782	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:120629782G>A	ENST00000310396.5	+	2	574	c.107G>A	c.(106-108)cGa>cAa	p.R36Q	CPED1_ENST00000495036.1_3'UTR|CPED1_ENST00000340646.5_Missense_Mutation_p.R36Q|CPED1_ENST00000450913.2_Missense_Mutation_p.R36Q	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		CTGACCCTCCGAGGGTCGAGG	0.577000													7	115					0	0	1	0	0
RRP36	88745	broad.mit.edu	37	6	42995194	42995194	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:42995194C>T	ENST00000244496.5	+	6	632	c.622C>T	c.(622-624)Cgg>Tgg	p.R208W		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	208					ribosomal small subunit biogenesis|rRNA processing	nucleolus				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						GCAGGGCCATCGGCCATACTT	0.572000													22	91					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38976345	38976345	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:38976345C>G	ENST00000355481.4	+	34	5181	c.5050C>G	c.(5050-5052)Ctg>Gtg	p.L1684V	RYR1_ENST00000359596.3_Missense_Mutation_p.L1684V|RYR1_ENST00000360985.3_Missense_Mutation_p.L1684V	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1684	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCGCACGCTCTGTGCAGCCA	0.672000													21	58					0	0	1	0	0
TNS4	84951	broad.mit.edu	37	17	38640801	38640801	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:38640801T>A	ENST00000254051.6	-	6	1594	c.1436A>T	c.(1435-1437)tAc>tTc	p.Y479F		NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4	479	SH2.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GGAGCCTCGGTATGAAGAGCT	0.587000													12	50					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57877218	57877218	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:57877218G>A	ENST00000381227.1	+	14	2165	c.1752G>A	c.(1750-1752)atG>atA	p.M584I	POLR2B_ENST00000431623.2_Missense_Mutation_p.M509I|POLR2B_ENST00000314595.5_Missense_Mutation_p.M584I|POLR2B_ENST00000510355.1_3'UTR|POLR2B_ENST00000441246.2_Missense_Mutation_p.M577I			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	584					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					AACAACTTATGAACACCCTAA	0.368000													5	71					0	0	1	0	0
SYF2	25949	broad.mit.edu	37	1	25551510	25551510	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:25551510G>A	ENST00000236273.4	-	6	574	c.549C>T	c.(547-549)gtC>gtT	p.V183V	SYF2_ENST00000354361.3_Silent_p.V141V	NM_015484.4	NP_056299.1	O95926	SYF2_HUMAN	SYF2 pre-mRNA-splicing factor	183						catalytic step 2 spliceosome				kidney(1)|large_intestine(1)|lung(4)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)		CCAGATCTATGACCATCCTGT	0.398000													20	91					0	0	1	0	0
ZNF644	84146	broad.mit.edu	37	1	91406639	91406639	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:91406639T>A	ENST00000370440.1	-	3	489	c.272A>T	c.(271-273)cAg>cTg	p.Q91L	ZNF644_ENST00000467231.1_Intron|ZNF644_ENST00000337393.5_Missense_Mutation_p.Q91L|ZNF644_ENST00000347275.5_Intron|ZNF644_ENST00000361321.5_Intron			Q9H582	ZN644_HUMAN	zinc finger protein 644	91					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TAGACTAGACTGGCCTCCACT	0.403000													25	101					0	0	1	0	0
CCDC77	84318	broad.mit.edu	37	12	521094	521094	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:521094G>A	ENST00000239830.4	+	4	399	c.220G>A	c.(220-222)Gag>Aag	p.E74K	CCDC77_ENST00000540180.1_Missense_Mutation_p.E42K|CCDC77_ENST00000540344.1_3'UTR|CCDC77_ENST00000412006.2_Missense_Mutation_p.E42K|CCDC77_ENST00000422000.1_Missense_Mutation_p.E42K	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	74						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			GGCAGAAAATGAGGACTTGCT	0.453000													7	91					0	0	1	0	0
WDR47	22911	broad.mit.edu	37	1	109526005	109526005	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:109526005T>G	ENST00000357672.3	-	10	2285	c.1910A>C	c.(1909-1911)tAc>tCc	p.Y637S	WDR47_ENST00000400794.3_Missense_Mutation_p.Y673S|WDR47_ENST00000369962.3_Missense_Mutation_p.Y665S|WDR47_ENST00000369965.4_Missense_Mutation_p.Y666S|WDR47_ENST00000361054.3_Missense_Mutation_p.Y637S			O94967	WDR47_HUMAN	WD repeat domain 47	665										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		GGCCACACAGTAAATGGATCC	0.398000													17	63					0	0	1	0	0
LOC146880	146880	broad.mit.edu	37	17	62758608	62758608	+	RNA	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:62758608G>A	ENST00000400873.3	-	0	1337					NR_026899.1																						CTCTCCTGCTGGAGTCAGACA	0.418000													22	67					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61564032	61564032	+	Nonsense_Mutation	SNP	C	C	T	rs139263584		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:61564032C>T	ENST00000577647.1	+	3	496	c.451C>T	c.(451-453)Cag>Tag	p.Q151*	ACE_ENST00000413513.3_Nonsense_Mutation_p.Q151*|ACE_ENST00000290863.6_Nonsense_Mutation_p.Q151*|ACE_ENST00000290866.4_Nonsense_Mutation_p.Q725*|ACE_ENST00000490216.2_Nonsense_Mutation_p.Q151*|ACE_ENST00000428043.1_Nonsense_Mutation_p.Q725*|ACE_ENST00000421982.2_Nonsense_Mutation_p.Q35*			P12821	ACE_HUMAN	angiotensin I converting enzyme	725	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	AAAGAAGGTTCAGGACCTAGA	0.567000													10	53					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43333177	43333177	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:43333177C>A	ENST00000361428.2	-	2	478	c.399_splice	c.e2-1	p.R134_splice	ZNF318_ENST00000318149.3_Splice_Site_p.R134_splice	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	134					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			AGGAGAGCGTCTCTACAAAAG	0.458000													19	58					1.56452e-12	1.89015e-12	1	1	0
MS4A14	84689	broad.mit.edu	37	11	60184183	60184183	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:60184183C>A	ENST00000300187.6	+	5	2019	c.1742C>A	c.(1741-1743)tCt>tAt	p.S581Y	MS4A14_ENST00000531787.1_Missense_Mutation_p.S469Y|MS4A14_ENST00000395005.2_Missense_Mutation_p.S564Y|MS4A14_ENST00000531783.1_Missense_Mutation_p.S614Y	NM_032597.4	NP_115986.3	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member 14	581	Gln-rich.					integral to membrane	receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(9)|lung(31)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	62						GAAGGACAATCTAAAGATGGA	0.448000													9	37					0.0581538	0.0587069	1	1	0
EXTL2	2135	broad.mit.edu	37	1	101343406	101343406	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:101343406C>T	ENST00000370114.3	-	3	1495	c.59G>A	c.(58-60)cGa>cAa	p.R20Q	EXTL2_ENST00000370113.3_Missense_Mutation_p.R20Q|EXTL2_ENST00000535414.1_Missense_Mutation_p.R7Q	NM_001033025.2|NM_001261440.1	NP_001028197.1|NP_001248369.1	Q9UBQ6	EXTL2_HUMAN	exostosin-like glycosyltransferase 2	20					N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	14		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		CAAAGATAATCGAAGCACTCG	0.438000													7	38					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108479211	108479211	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:108479211G>A	ENST00000408999.3	+	16	2356	c.2279G>A	c.(2278-2280)gGa>gAa	p.G760E	RGPD4_ENST00000354986.4_Missense_Mutation_p.G760E	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	760					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						TATAGTGAAGGAGATCCTCTC	0.368000													25	133					0	0	1	0	0
DNAJC2	27000	broad.mit.edu	37	7	102960065	102960065	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:102960065C>T	ENST00000379263.3	-	12	1483	c.1233G>A	c.(1231-1233)ttG>ttA	p.L411L	PMPCB_ENST00000420236.2_Intron|DNAJC2_ENST00000249270.7_Intron	NM_014377.1	NP_055192.1	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	411					'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			endometrium(1)|kidney(9)|large_intestine(6)|lung(4)|ovary(1)	21						CCTGTTTTTCCAAAGCAGCCT	0.353000													5	67					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72190168	72190168	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:72190168G>A	ENST00000356056.5	-	25	5148	c.4676C>T	c.(4675-4677)tCt>tTt	p.S1559F	MYO9A_ENST00000424560.1_Missense_Mutation_p.S1559F|MYO9A_ENST00000564571.1_Missense_Mutation_p.S1559F|MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000444904.1_Missense_Mutation_p.S1540F|MYO9A_ENST00000566885.1_Missense_Mutation_p.S1179F	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	1559	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						GCTGAGGAGAGAGGATGGCCT	0.443000													5	45					0	0	1	0	0
PHLDB3	653583	broad.mit.edu	37	19	44001363	44001363	+	Silent	SNP	C	C	T	rs150671965	byFrequency	TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:44001363C>T	ENST00000292140.5	-	6	1092	c.732G>A	c.(730-732)gaG>gaA	p.E244E	PHLDB3_ENST00000599242.1_Silent_p.E244E	NM_198850.3	NP_942147.3	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B, member 3	244										breast(1)|central_nervous_system(1)|lung(5)	7		Prostate(69;0.0153)				CCTGCCGGCTCTCCCGCTCCA	0.622000													11	37					0	0	1	0	0
WDR91	29062	broad.mit.edu	37	7	134889090	134889090	+	Nonsense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:134889090G>C	ENST00000354475.4	-	6	852	c.821C>G	c.(820-822)tCa>tGa	p.S274*	WDR91_ENST00000344400.5_Nonsense_Mutation_p.S274*|WDR91_ENST00000423565.1_Nonsense_Mutation_p.S239*|WDR91_ENST00000485942.1_5'UTR	NM_014149.3	NP_054868.3	A4D1P6	WDR91_HUMAN	WD repeat domain 91	274										breast(3)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	40						CGACAACCTTGAGGGGCTCTT	0.587000													14	41					0	0	1	0	0
KRT84	3890	broad.mit.edu	37	12	52776281	52776281	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:52776281G>A	ENST00000257951.3	-	4	918	c.852C>T	c.(850-852)ctC>ctT	p.L284L	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	284	Coil 1B.|Rod.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CGTTGGCCTCGAGATCAGACT	0.458000													17	71					0	0	1	0	0
HDGFRP3	50810	broad.mit.edu	37	15	83832755	83832755	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:83832755C>T	ENST00000299633.4	-	2	760	c.157G>A	c.(157-159)Gaa>Aaa	p.E53K		NM_016073.3	NP_057157.1	Q9Y3E1	HDGR3_HUMAN		53	PWWP.				cell proliferation	nucleus	growth factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						ACTTACGTTTCATGGGTGCCA	0.383000													22	104					0	0	1	0	0
PEAK1	79834	broad.mit.edu	37	15	77407481	77407481	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:77407481C>T	ENST00000560626.2	-	7	4733	c.4258G>A	c.(4258-4260)Gag>Aag	p.E1420K	PEAK1_ENST00000312493.4_Missense_Mutation_p.E1420K			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1420	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										TCTTCAGTCTCTTCCATGTCA	0.498000													21	133					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34671615	34671615	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:34671615G>A	ENST00000374789.3	-	9	1577	c.1252C>T	c.(1252-1254)Cac>Tac	p.H418Y	PARD3_ENST00000374773.1_Missense_Mutation_p.H418Y|PARD3_ENST00000374776.1_Missense_Mutation_p.H418Y|PARD3_ENST00000350537.4_Missense_Mutation_p.H418Y|PARD3_ENST00000545693.1_Missense_Mutation_p.H418Y|PARD3_ENST00000545260.1_Missense_Mutation_p.H374Y|PARD3_ENST00000374790.3_Missense_Mutation_p.H374Y|PARD3_ENST00000374794.3_Missense_Mutation_p.H374Y|PARD3_ENST00000374788.3_Missense_Mutation_p.H418Y|PARD3_ENST00000340077.5_Missense_Mutation_p.H418Y|PARD3_ENST00000544292.1_Missense_Mutation_p.H148Y|PARD3_ENST00000346874.4_Missense_Mutation_p.H418Y	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	418					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				AGTCTTGAGTGAGAGTCTATC	0.537000													14	64					0	0	1	0	0
HTR5A	3361	broad.mit.edu	37	7	154875961	154875961	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:154875961G>C	ENST00000287907.2	+	2	1414	c.838G>C	c.(838-840)Gag>Cag	p.E280Q	HTR5A_ENST00000486819.1_3'UTR	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	280						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GGAGCAGAAGGAGCAGCGGGC	0.627000													21	62					0	0	1	0	0
STYXL1	51657	broad.mit.edu	37	7	75625800	75625800	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:75625800C>A	ENST00000248600.1	-	9	1270	c.928G>T	c.(928-930)Gat>Tat	p.D310Y	STYXL1_ENST00000359697.3_Missense_Mutation_p.D310Y|STYXL1_ENST00000431581.1_Missense_Mutation_p.D310Y|STYXL1_ENST00000360591.3_3'UTR|STYXL1_ENST00000340062.5_Missense_Mutation_p.D214Y	NM_016086.2	NP_057170.1	Q9Y6J8	STYL1_HUMAN	serine/threonine/tyrosine interacting-like 1	310					intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	10						TAGAGCGGATCCATGATGTTT	0.527000													17	45					3.32936e-07	3.69763e-07	1	1	0
ABCC3	8714	broad.mit.edu	37	17	48755124	48755124	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:48755124C>T	ENST00000285238.8	+	24	3478	c.3398C>T	c.(3397-3399)tCa>tTa	p.S1133L		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1133	ABC transmembrane type-1 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GCAGCCACATCACGGCAACTG	0.562000													50	207					0	0	1	0	0
MGRN1	23295	broad.mit.edu	37	16	4731731	4731731	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:4731731G>T	ENST00000399577.5	+	13	1405	c.1312G>T	c.(1312-1314)Gac>Tac	p.D438Y	MGRN1_ENST00000588994.1_Missense_Mutation_p.D416Y|MGRN1_ENST00000415496.1_Missense_Mutation_p.D417Y|MGRN1_ENST00000262370.7_Missense_Mutation_p.D438Y|MGRN1_ENST00000586183.1_Missense_Mutation_p.D416Y	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase	438					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						CCACATCCTGGACAGCAGCCG	0.662000													14	37					7.93312e-07	8.74527e-07	1	1	0
NLRP9	338321	broad.mit.edu	37	19	56223264	56223264	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:56223264C>T	ENST00000332836.2	-	8	2772	c.2745G>A	c.(2743-2745)ctG>ctA	p.L915L		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	915						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TCAGGCTCCTCAGTGTTTTGC	0.587000													5	59					0	0	1	0	0
IGLV5-52	28779	broad.mit.edu	37	22	22673515	22673515	+	RNA	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:22673515C>G	ENST00000390289.2	+	0	313				LL22NC03-80A10.6_ENST00000426066.1_RNA																							CTGCGTATCTCTGGGCTCCAG	0.522000													37	187					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99093239	99093239	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:99093239C>G	ENST00000357310.1	+	17	2935	c.2358C>G	c.(2356-2358)ttC>ttG	p.F786L	APAF1_ENST00000359972.2_Missense_Mutation_p.F775L|APAF1_ENST00000552268.1_Intron|APAF1_ENST00000547045.1_Missense_Mutation_p.F786L|APAF1_ENST00000550527.1_Missense_Mutation_p.F775L|APAF1_ENST00000549007.1_Missense_Mutation_p.F786L|APAF1_ENST00000551964.1_Missense_Mutation_p.F786L|APAF1_ENST00000339433.3_Missense_Mutation_p.F786L|APAF1_ENST00000333991.1_Intron	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	786					activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	TGAAACAGTTCTTCCTAAATT	0.363000													6	61					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55541004	55541004	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:55541004C>G	ENST00000361760.1	+	1	91	c.91C>G	c.(91-93)Ctg>Gtg	p.L31V		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	31					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L31M(1)		breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TCCACTCTTTCTGGTTTTCTT	0.388000													44	145					0	0	1	0	0
PMP2	5375	broad.mit.edu	37	8	82359623	82359623	+	Translation_Start_Site	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:82359623G>A	ENST00000256103.2	-	0	135				RP11-157I4.4_ENST00000524085.2_RNA|PMP2_ENST00000519260.1_De_novo_Start_InFrame	NM_002677.3	NP_002668.1	P02689	MYP2_HUMAN	peripheral myelin protein 2							cytoplasm	cholesterol binding|fatty acid binding|transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)	6			Epithelial(68;0.186)			GTTGCTCATCGTGATGGGTGA	0.438000													22	69					0	0	1	0	0
IL17F	112744	broad.mit.edu	37	6	52103659	52103659	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:52103659G>A	ENST00000336123.4	-	2	230	c.123C>T	c.(121-123)ttC>ttT	p.F41F		NM_052872.3	NP_443104.1	Q96PD4	IL17F_HUMAN	interleukin 17F	41					cartilage development|inflammatory response|lymphotoxin A biosynthetic process|negative regulation of angiogenesis|proteoglycan metabolic process|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|regulation of interleukin-2 biosynthetic process|regulation of interleukin-6 biosynthetic process|regulation of interleukin-8 biosynthetic process|regulation of transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|cytokine binding|protein homodimerization activity			NS(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)	14	Lung NSC(77;0.116)					CAGGCTTTTGGAAAAAAGTAT	0.488000													19	69					0	0	1	0	0
CMKLR1	1240	broad.mit.edu	37	12	108685647	108685647	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:108685647T>C	ENST00000312143.7	-	3	1456	c.1093A>G	c.(1093-1095)Atg>Gtg	p.M365V	CMKLR1_ENST00000412676.1_Missense_Mutation_p.M365V|CMKLR1_ENST00000552995.1_Missense_Mutation_p.M363V|CMKLR1_ENST00000550402.1_Missense_Mutation_p.M365V|CMKLR1_ENST00000397688.2_Missense_Mutation_p.M363V	NM_001142344.1|NM_004072.2	NP_001135816.1|NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	365					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						CTCTCATTCATAGAAGTCCTC	0.488000													28	83					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21789371	21789371	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:21789371G>T	ENST00000328843.6	+	54	8801	c.8770G>T	c.(8770-8772)Gtt>Ttt	p.V2924F	DNAH11_ENST00000409508.3_Missense_Mutation_p.V2917F			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2924	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGATGCCCAGGTTCTAGATGA	0.448000									Kartagener syndrome				10	62					1.33987e-11	1.59539e-11	1	1	0
ATM	472	broad.mit.edu	37	11	108155180	108155180	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:108155180G>C	ENST00000278616.4	+	26	4358	c.3973G>C	c.(3973-3975)Gaa>Caa	p.E1325Q	ATM_ENST00000452508.2_Missense_Mutation_p.E1325Q	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1325					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.V1292_Q1331del(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GCTTAAAAGTGAAAACTTATT	0.353000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			11	72					0	0	1	0	0
GBP6	163351	broad.mit.edu	37	1	89849809	89849809	+	Silent	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:89849809G>C	ENST00000370456.4	+	10	1719	c.1626G>C	c.(1624-1626)ctG>ctC	p.L542L	GBP6_ENST00000535065.1_Silent_p.L412L	NM_198460.2	NP_940862.2	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	542							GTP binding|GTPase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		AACACCTACTGAGAGAGCAGA	0.537000													5	22					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	13182882	13182882	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:13182882G>T	ENST00000379350.1	+	6	757	c.628G>T	c.(628-630)Gag>Tag	p.E210*	PHACTR1_ENST00000379345.2_Nonsense_Mutation_p.E65*|PHACTR1_ENST00000332995.7_Nonsense_Mutation_p.E210*|PHACTR1_ENST00000457702.2_Nonsense_Mutation_p.E65*			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	210						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CTGCTCATATGAGGTGCTCCA	0.597000													29	87					6.38683e-12	7.62929e-12	1	1	0
ALDH4A1	8659	broad.mit.edu	37	1	19211985	19211985	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:19211985G>T	ENST00000375341.3	-	5	692	c.435C>A	c.(433-435)gcC>gcA	p.A145A	ALDH4A1_ENST00000538839.1_Silent_p.A145A|ALDH4A1_ENST00000538309.1_Silent_p.A85A|ALDH4A1_ENST00000290597.5_Silent_p.A145A|RP13-279N23.2_ENST00000494072.3_3'UTR|ALDH4A1_ENST00000454547.1_5'UTR	NM_003748.3	NP_003739.2	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4 family, member A1	145					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	ccATGGTCTTGGCGAGGATCT	0.662000													3	4					0.115264	0.116045	1	1	0
KLK11	11012	broad.mit.edu	37	19	51527441	51527441	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:51527441C>T	ENST00000594768.1	-	4	604	c.419G>A	c.(418-420)cGc>cAc	p.R140H	KLK11_ENST00000391804.3_Missense_Mutation_p.R133H|KLK11_ENST00000319720.7_Missense_Mutation_p.R108H|KLK11_ENST00000453757.3_Missense_Mutation_p.R108H|KLK11_ENST00000600362.1_Intron	NM_144947.1	NP_659196.1	Q9UBX7	KLK11_HUMAN	kallikrein-related peptidase 11	140	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|skin(1)	7		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|GBM - Glioblastoma multiforme(134;0.00878)		GATGTCATTGCGGTGGTCTTT	0.612000													14	32					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33955104	33955104	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:33955104C>G	ENST00000389232.4	+	35	5443	c.5373C>G	c.(5371-5373)gtC>gtG	p.V1791V	RYR3_ENST00000415757.3_Silent_p.V1791V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1791	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGGCTCCTGTCAAAGGCTTGT	0.547000													55	177					0	0	1	0	0
APOBEC4	403314	broad.mit.edu	37	1	183617477	183617477	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:183617477C>A	ENST00000308641.4	-	2	711	c.440G>T	c.(439-441)gGc>gTc	p.G147V	RGL1_ENST00000536277.1_Intron|APOBEC4_ENST00000481562.1_Intron|RGL1_ENST00000367531.1_Intron|RGL1_ENST00000304685.3_Intron	NM_203454.2	NP_982279.1	Q8WW27	ABEC4_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)	147					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(6)|skin(1)	21						AAGAGTGATGCCTGGATACGT	0.443000													34	208					8.4185e-14	1.03047e-13	1	1	0
RIF1	55183	broad.mit.edu	37	2	152320185	152320185	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:152320185C>A	ENST00000243326.4	+	29	4634	c.4151C>A	c.(4150-4152)tCc>tAc	p.S1384Y	RIF1_ENST00000430328.2_Missense_Mutation_p.S1384Y|RIF1_ENST00000444746.2_Missense_Mutation_p.S1384Y|RIF1_ENST00000428287.2_Missense_Mutation_p.S1384Y|RIF1_ENST00000453091.2_Missense_Mutation_p.S1384Y			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	1384					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		AATTTGGAATCCAAAGAGAAT	0.363000													25	101					1.33986e-20	1.70174e-20	1	1	0
OR1A2	26189	broad.mit.edu	37	17	3101279	3101279	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:3101279C>A	ENST00000381951.1	+	1	467	c.467C>A	c.(466-468)gCt>gAt	p.A156D		NM_012352.1	NP_036484.1	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A, member 2	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(4)|stomach(2)	18						AACACCAGTGCTCTCCCCCAC	0.488000													30	90					1.74197e-06	1.90336e-06	1	1	0
GMPR2	51292	broad.mit.edu	37	14	24705212	24705212	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr14:24705212G>C	ENST00000557854.1	+	4	662	c.385G>C	c.(385-387)Gag>Cag	p.E129Q	GMPR2_ENST00000456667.3_Missense_Mutation_p.E83Q|GMPR2_ENST00000399440.2_Missense_Mutation_p.E111Q|GMPR2_ENST00000559910.1_Missense_Mutation_p.E111Q|GMPR2_ENST00000559836.1_Missense_Mutation_p.E111Q|GMPR2_ENST00000559104.1_Missense_Mutation_p.E129Q|GMPR2_ENST00000348719.7_Missense_Mutation_p.E111Q|GMPR2_ENST00000355299.4_Missense_Mutation_p.E111Q|GMPR2_ENST00000420554.2_Missense_Mutation_p.E129Q			Q9P2T1	GMPR2_HUMAN	guanosine monophosphate reductase 2	111					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage	cytosol	GMP reductase activity|metal ion binding			large_intestine(4)|lung(3)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(265;0.0181)		TTCTGACTTTGAGCAGCTGGA	0.488000													16	60					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10469027	10469027	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:10469027G>A	ENST00000382483.3	-	4	2804	c.2581C>T	c.(2581-2583)Ccc>Tcc	p.P861S		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	861					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TGGGGGCAGGGCCGCCCCCTG	0.736000													3	6					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79320766	79320766	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:79320766C>G	ENST00000428286.1	-	8	6547	c.5347G>C	c.(5347-5349)Gat>Cat	p.D1783H	PRUNE2_ENST00000376718.3_Missense_Mutation_p.D2142H			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2142					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GGTTCTTCATCTATCTCTGGC	0.488000													9	124					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113547974	113547974	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:113547974C>A	ENST00000416899.2	+	11	1856	c.1730C>A	c.(1729-1731)gCg>gAg	p.A577E	MUSK_ENST00000374438.1_Missense_Mutation_p.A101E|MUSK_ENST00000189978.5_Missense_Mutation_p.A585E|MUSK_ENST00000374448.4_Missense_Mutation_p.A585E			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	585	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						GGAGAGGGAGCGTTTGGAAGG	0.423000													14	63					9.31168e-06	1.00269e-05	1	1	0
USH1G	124590	broad.mit.edu	37	17	72915569	72915569	+	Silent	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:72915569C>A	ENST00000319642.1	-	2	1544	c.1362G>T	c.(1360-1362)ccG>ccT	p.P454P		NM_173477.2	NP_775748.2	Q495M9	USH1G_HUMAN	Usher syndrome 1G (autosomal recessive)	454					equilibrioception|photoreceptor cell maintenance|sensory perception of sound	actin cytoskeleton			HN1/USH1G(2)	endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(3)	14	all_lung(278;0.172)|Lung NSC(278;0.207)					CCTCCAGGGCCGGCGGGCGCT	0.682000													10	32					3.07112e-06	3.33115e-06	1	1	0
TIAM1	7074	broad.mit.edu	37	21	32595897	32595897	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr21:32595897C>A	ENST00000286827.3	-	9	2291	c.1820G>T	c.(1819-1821)tGg>tTg	p.W607L	TIAM1_ENST00000541036.1_Missense_Mutation_p.W607L|TIAM1_ENST00000469412.1_5'UTR	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	607					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						ATTTTGCTCCCAGACAAAGAT	0.423000													16	57					6.94344e-10	8.12438e-10	1	1	0
SH3YL1	26751	broad.mit.edu	37	2	233127	233127	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:233127C>T	ENST00000403657.1	-	9	2414	c.219G>A	c.(217-219)ttG>ttA	p.L73L	SH3YL1_ENST00000415006.2_Silent_p.L73L|SH3YL1_ENST00000468321.1_5'UTR|SH3YL1_ENST00000356150.5_Silent_p.L169L|SH3YL1_ENST00000405430.1_Silent_p.L169L|SH3YL1_ENST00000403712.2_Silent_p.L169L|SH3YL1_ENST00000403658.1_Silent_p.L73L			Q96HL8	SH3Y1_HUMAN	SH3 and SYLF domain containing 1	169										large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	7	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.034)		all cancers(51;0.000647)|Epithelial(75;0.0043)|OV - Ovarian serous cystadenocarcinoma(76;0.00871)|GBM - Glioblastoma multiforme(21;0.148)		TCCTTTCAATCAAACAGCTCC	0.403000													5	30					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92352717	92352717	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:92352717G>T	ENST00000276609.3	+	8	1203	c.964G>T	c.(964-966)Gcc>Tcc	p.A322S	SLC26A7_ENST00000523719.1_Missense_Mutation_p.A322S|SLC26A7_ENST00000309536.2_Missense_Mutation_p.A322S	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	322						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			AGGCTATGTGGCCTCACTGGC	0.502000													29	78					2.08457e-15	2.59002e-15	1	1	0
F12	2161	broad.mit.edu	37	5	176830358	176830358	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:176830358C>T	ENST00000253496.3	-	12	1476	c.1428G>A	c.(1426-1428)gcG>gcA	p.A476A	F12_ENST00000514943.1_5'UTR	NM_000505.3	NP_000496.2	P00748	FA12_HUMAN	coagulation factor XII (Hageman factor)	476	Peptidase S1.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCGACAGGAGCGCGCAGCTGC	0.716000									Hereditary Angioedema				5	44					0	0	1	0	0
FGF12	2257	broad.mit.edu	37	3	191888366	191888366	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:191888366C>T	ENST00000454309.2	-	4	1319	c.494G>A	c.(493-495)cGc>cAc	p.R165H	FGF12_ENST00000430714.1_Missense_Mutation_p.R66H|FGF12_ENST00000450716.1_Missense_Mutation_p.R103H|FGF12_ENST00000264730.3_Missense_Mutation_p.R103H|FGF12_ENST00000445105.1_Missense_Mutation_p.R103H	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	165					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		TTCTTGCTGGCGGTACAGTGT	0.393000													14	243					0	0	1	0	0
PTPN22	26191	broad.mit.edu	37	1	114380719	114380719	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:114380719C>A	ENST00000359785.5	-	13	1438	c.1303G>T	c.(1303-1305)Gga>Tga	p.G435*	PTPN22_ENST00000420377.2_Nonsense_Mutation_p.G435*|PTPN22_ENST00000528414.1_Nonsense_Mutation_p.G380*|PTPN22_ENST00000525799.1_Nonsense_Mutation_p.G308*|PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000538253.1_Nonsense_Mutation_p.G191*	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	435					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATATCTTCCTGCTGCATTT	0.398000													21	70					8.10497e-08	9.1659e-08	1	1	0
CCDC105	126402	broad.mit.edu	37	19	15124540	15124540	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:15124540G>A	ENST00000292574.3	+	2	709	c.627G>A	c.(625-627)atG>atA	p.M209I		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	209					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						TGAAAAGCATGAAGAGGAAAA	0.498000													12	25					0	0	1	0	0
AHCTF1	25909	broad.mit.edu	37	1	247039463	247039463	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:247039463C>G	ENST00000366508.1	-	24	3205	c.3069G>C	c.(3067-3069)gaG>gaC	p.E1023D	AHCTF1_ENST00000391829.2_Missense_Mutation_p.E988D|AHCTF1_ENST00000326225.3_Missense_Mutation_p.E997D|AHCTF1_ENST00000470300.1_5'UTR			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	988					cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CCAGTGATCTCTCCCGCAAAC	0.348000													8	56					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179477781	179477781	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:179477781C>T	ENST00000589042.1	-	265	49891	c.49667G>A	c.(49666-49668)gGa>gAa	p.G16556E	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G14915E|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G13988E|TTN_ENST00000342175.6_Missense_Mutation_p.G7683E|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G7616E|TTN_ENST00000460472.2_Missense_Mutation_p.G7491E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14915	Fibronectin type-III 20.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTGGTTTTCCAGGGGGCCA	0.363000													23	47					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77386716	77386716	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:77386716G>A	ENST00000451710.3	-	25	3676	c.3439C>T	c.(3439-3441)Cat>Tat	p.H1147Y	TRPM6_ENST00000361255.3_Missense_Mutation_p.H1142Y|TRPM6_ENST00000360774.1_Missense_Mutation_p.H1147Y|TRPM6_ENST00000449912.2_Missense_Mutation_p.H1142Y|TRPM6_ENST00000376864.4_Missense_Mutation_p.H1147Y|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1147					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TCAAAATCATGAAGTTTTTTC	0.388000													13	69					0	0	1	0	0
ATG4B	23192	broad.mit.edu	37	2	242610823	242610823	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:242610823G>A	ENST00000405546.3	+	12	1613	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	ATG4B_ENST00000396411.3_Intron|ATG4B_ENST00000474739.2_Intron|ATG4B_ENST00000404914.3_Intron|ATG4B_ENST00000402096.1_Missense_Mutation_p.E297K			Q9Y4P1	ATG4B_HUMAN	autophagy related 4B, cysteine peptidase	371					autophagic vacuole assembly|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity|protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.44e-33)|all cancers(36;5.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.75e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0848)		GTCCCTAGGTGAGAGCTGCCA	0.602000													4	21					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38973702	38973702	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:38973702C>A	ENST00000355481.4	+	32	4787	c.4656C>A	c.(4654-4656)ttC>ttA	p.F1552L	RYR1_ENST00000359596.3_Missense_Mutation_p.F1552L|RYR1_ENST00000360985.3_Missense_Mutation_p.F1552L	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1552	6 X approximate repeats.|B30.2/SPRY 3.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTGCCGTCTTCGTCCTGCCCA	0.592000													22	87					3.08376e-08	3.52498e-08	1	1	0
F13B	2165	broad.mit.edu	37	1	197024868	197024868	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:197024868C>A	ENST00000367412.1	-	8	1374	c.1331G>T	c.(1330-1332)tGg>tTg	p.W444L		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	444	Sushi 7.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TGGGGATGACCATTTTCCTTG	0.363000													20	137					1.28384e-07	1.43227e-07	1	1	0
PPP3CA	5530	broad.mit.edu	37	4	101947147	101947147	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:101947147C>A	ENST00000394854.3	-	14	2124	c.1441G>T	c.(1441-1443)Gag>Tag	p.E481*	PPP3CA_ENST00000512215.1_Nonsense_Mutation_p.E249*|PPP3CA_ENST00000394853.4_Nonsense_Mutation_p.E471*|PPP3CA_ENST00000523694.2_Nonsense_Mutation_p.E414*|PPP3CA_ENST00000323055.6_Nonsense_Mutation_p.E429*|PPP3CA_ENST00000507176.1_Nonsense_Mutation_p.E383*	NM_000944.4	NP_000935.1	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha isozyme	481	Inhibitory domain.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		GGCATCCTCTCATTAATTCGG	0.458000													28	122					1.04121e-07	1.17215e-07	1	1	0
TRPS1	7227	broad.mit.edu	37	8	116426596	116426596	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:116426596C>G	ENST00000395715.3	-	7	4117	c.3540G>C	c.(3538-3540)gcG>gcC	p.A1180A	TRPS1_ENST00000220888.5_Silent_p.A1167A|TRPS1_ENST00000520276.1_Silent_p.A1171A|TRPS1_ENST00000519076.1_Silent_p.A921A	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	1167	Mediates interaction with RNF4 (By similarity).|Transcriptional repressor domain (By similarity).				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AATGCTTGATCGCCAAATCTA	0.448000									Langer-Giedion syndrome				7	33					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64166700	64166700	+	Splice_Site	SNP	A	A	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:64166700A>T	ENST00000395391.1	+	4	1394		c.e4-1		ZNF107_ENST00000344930.3_Splice_Site|ZNF107_ENST00000423627.1_Splice_Site			Q9UII5	ZN107_HUMAN	zinc finger protein 107						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				TATTTCTTTCAGTAATGTCTT	0.308000													9	62					0	0	1	0	0
DACH1	1602	broad.mit.edu	37	13	72256022	72256022	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr13:72256022G>A	ENST00000305425.4	-	2	1297	c.875C>T	c.(874-876)cCt>cTt	p.P292L	DACH1_ENST00000313174.7_Missense_Mutation_p.P292L|DACH1_ENST00000354591.4_Missense_Mutation_p.P292L|DACH1_ENST00000359684.2_Missense_Mutation_p.P292L	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	290	Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGTCCTCTTAGGAGGCCTTCC	0.413000													12	40					0	0	1	0	0
NOD1	10392	broad.mit.edu	37	7	30492319	30492319	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:30492319C>T	ENST00000222823.4	-	6	1239	c.714G>A	c.(712-714)atG>atA	p.M238I	NOD1_ENST00000423334.2_Intron	NM_006092.2	NP_006083.1	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain containing 1	238	NACHT.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						AGCAGCTGAACATGCGGCAGC	0.602000													22	73					0	0	1	0	0
GLT1D1	144423	broad.mit.edu	37	12	129442186	129442186	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:129442186C>T	ENST00000442111.2	+	11	965	c.877C>T	c.(877-879)Cag>Tag	p.Q293*	GLT1D1_ENST00000537468.1_Nonsense_Mutation_p.Q298*|GLT1D1_ENST00000542193.1_Nonsense_Mutation_p.Q210*|GLT1D1_ENST00000281703.6_Nonsense_Mutation_p.Q213*			Q96MS3	GL1D1_HUMAN	glycosyltransferase 1 domain containing 1	293					biosynthetic process	extracellular region	transferase activity, transferring glycosyl groups			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	26	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.97e-06)|Epithelial(86;3.97e-05)|all cancers(50;0.00019)		TTCCAATCCTCAGGTAAAGAA	0.443000													4	46					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195492285	195492285	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:195492285C>T	ENST00000463781.3	-	9	14113	c.13654G>A	c.(13654-13656)Gaa>Aaa	p.E4552K	MUC4_ENST00000475231.1_Missense_Mutation_p.E4500K|MUC4_ENST00000349607.4_Missense_Mutation_p.E265K|MUC4_ENST00000346145.4_Missense_Mutation_p.E316K	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	1309					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGCCTTTCTTCCCGGTGTAGC	0.642000													7	45					0	0	1	0	0
KIF16B	55614	broad.mit.edu	37	20	16486496	16486496	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:16486496C>G	ENST00000354981.2	-	9	1028	c.871G>C	c.(871-873)Gat>Cat	p.D291H	KIF16B_ENST00000378003.2_5'UTR|KIF16B_ENST00000355755.3_Missense_Mutation_p.D291H|KIF16B_ENST00000408042.1_Missense_Mutation_p.D291H	NM_001199865.1|NM_024704.4	NP_001186794.1|NP_078980.3	Q96L93	KI16B_HUMAN	kinesin family member 16B	291	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(24)|ovary(1)|prostate(15)|skin(3)|upper_aerodigestive_tract(2)	74						TGAGATAAATCAGCTATGAAA	0.358000													15	34					0	0	1	0	0
IL37	27178	broad.mit.edu	37	2	113676327	113676327	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:113676327G>T	ENST00000263326.3	+	5	640	c.598G>T	c.(598-600)Gaa>Taa	p.E200*	IL37_ENST00000353225.3_Nonsense_Mutation_p.E160*|IL37_ENST00000349806.3_Nonsense_Mutation_p.E139*|IL37_ENST00000352179.3_Nonsense_Mutation_p.E179*|IL37_ENST00000311328.2_Nonsense_Mutation_p.E174*	NM_014439.3	NP_055254.2	Q9NZH6	IL37_HUMAN	interleukin 37	200					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(2)|skin(3)	19						GAAACACATTGAATTTTCATT	0.478000													9	41					2.17888e-05	2.32936e-05	1	1	0
EEF1B2	1933	broad.mit.edu	37	2	207027515	207027515	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:207027515G>A	ENST00000392222.2	+	6	961	c.586G>A	c.(586-588)Gat>Aat	p.D196N	EEF1B2_ENST00000236957.5_Missense_Mutation_p.D196N|EEF1B2_ENST00000392221.1_Missense_Mutation_p.D196N	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	196						cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGTTGAAGATGATAAAGTTGG	0.378000													4	72					0	0	1	0	0
CUTA	51596	broad.mit.edu	37	6	33384897	33384897	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:33384897C>A	ENST00000374500.5	-	4	528	c.397G>T	c.(397-399)Gag>Tag	p.E133*	CUTA_ENST00000607266.1_Nonsense_Mutation_p.E91*|CUTA_ENST00000374496.3_Nonsense_Mutation_p.E91*|CUTA_ENST00000488034.1_Nonsense_Mutation_p.E114*|CUTA_ENST00000488478.1_Nonsense_Mutation_p.E114*|CUTA_ENST00000440279.3_Nonsense_Mutation_p.E91*|CUTA_ENST00000494751.1_Nonsense_Mutation_p.E91*	NM_001014433.2	NP_001014433.1	O60888	CUTA_HUMAN	cutA divalent cation tolerance homolog (E. coli)	114					protein localization|response to metal ion	membrane	enzyme binding		SLC22A1/CUTA(2)	kidney(1)|lung(3)|urinary_tract(1)	5						CTGTCTTCCTCGATCTTCCCT	0.512000													14	107					2.62699e-14	3.24767e-14	1	1	0
KLHL31	401265	broad.mit.edu	37	6	53516497	53516497	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:53516497C>T	ENST00000370905.3	-	3	1944	c.1804G>A	c.(1804-1806)Gag>Aag	p.E602K	KLHL31_ENST00000407079.1_Missense_Mutation_p.E602K	NM_001003760.4	NP_001003760.2	Q9H511	KLH31_HUMAN	kelch-like family member 31	602					regulation of transcription, DNA-dependent|transcription, DNA-dependent					autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(3)	20	Lung NSC(77;0.0158)					ACAGTGGCCTCGGGTAGCTCG	0.612000											OREG0017507	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	89					0	0	1	0	0
ITPKC	80271	broad.mit.edu	37	19	41223333	41223333	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:41223333C>T	ENST00000263370.2	+	1	326	c.293C>T	c.(292-294)gCg>gTg	p.A98V		NM_025194.2	NP_079470.1	Q96DU7	IP3KC_HUMAN	inositol-trisphosphate 3-kinase C	98						cytoplasm|nucleus	ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	14			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			ACTGAGCCCGCGGCAGCTGGC	0.652000													13	36					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237806679	237806679	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:237806679C>T	ENST00000366574.2	+	48	7591	c.7274C>T	c.(7273-7275)tCc>tTc	p.S2425F	RYR2_ENST00000360064.6_Missense_Mutation_p.S2423F|RYR2_ENST00000542537.1_Missense_Mutation_p.S2409F	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2425	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATTTTGAGATCCCTCATTCCC	0.423000													44	166					0	0	1	0	0
MYO1D	4642	broad.mit.edu	37	17	30821873	30821873	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:30821873C>T	ENST00000318217.5	-	22	3229	c.2925G>A	c.(2923-2925)aaG>aaA	p.K975K	MYO1D_ENST00000394649.4_Silent_p.K887K	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	975						myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CGGTGCACTTCTTCCCGTGCA	0.607000													6	42					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20413882	20413882	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:20413882G>A	ENST00000380338.4	-	5	1248	c.962C>T	c.(961-963)tCt>tTt	p.S321F	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Missense_Mutation_p.S318F|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TTTGTCAGCAGAACAAGTGAG	0.373000			T	MLL	ALL								7	102					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19513101	19513101	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:19513101G>A	ENST00000375267.2	-	14	1686	c.1683C>T	c.(1681-1683)agC>agT	p.S561S	UBR4_ENST00000375254.3_Silent_p.S561S|UBR4_ENST00000375226.2_Silent_p.S561S|UBR4_ENST00000375217.2_Silent_p.S561S			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	561					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CGGTGGAGGCGCTGGCATCGC	0.522000													10	39					0	0	1	0	0
RFPL1	5988	broad.mit.edu	37	22	29834839	29834839	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:29834839C>T	ENST00000354373.2	+	1	268	c.59C>T	c.(58-60)cCc>cTc	p.P20L	RFPL1S_ENST00000461286.2_RNA	NM_021026.2	NP_066306.2	O75677	RFPL1_HUMAN	ret finger protein-like 1	20							zinc ion binding			endometrium(3)|large_intestine(1)|lung(6)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	16						AATTTTCTTCCCTTGTGCACT	0.468000													35	122					0	0	1	0	0
SP110	3431	broad.mit.edu	37	2	231036809	231036809	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:231036809C>T	ENST00000258381.6	-	16	1865	c.1788G>A	c.(1786-1788)gaG>gaA	p.E596E	SP110_ENST00000358662.4_Silent_p.E596E	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	596	Bromo.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		GCATCTGCCTCTCCAGGGTCT	0.522000													13	121					0	0	1	0	0
RAVER2	55225	broad.mit.edu	37	1	65243706	65243706	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:65243706C>T	ENST00000294428.3	+	3	795	c.717C>T	c.(715-717)ccC>ccT	p.P239P	RAVER2_ENST00000371072.4_Silent_p.P239P			Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	239	RRM 3.					cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						ATAAACTCCCCAGTGACTACA	0.383000													20	147					0	0	1	0	0
ACAD8	27034	broad.mit.edu	37	11	134128465	134128465	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:134128465G>C	ENST00000281182.4	+	4	543	c.437G>C	c.(436-438)tGc>tCc	p.C146S	ACAD8_ENST00000543332.1_Missense_Mutation_p.C48S|ACAD8_ENST00000537423.1_Missense_Mutation_p.C69S|ACAD8_ENST00000374752.4_Intron|ACAD8_ENST00000524547.1_Intron	NM_014384.2	NP_055199.1	Q9UKU7	ACAD8_HUMAN	acyl-CoA dehydrogenase family, member 8	146					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		CACAAATTTTGCCCACCGCTC	0.458000													10	35					0	0	1	0	0
NOXO1	124056	broad.mit.edu	37	16	2030672	2030672	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:2030672G>A	ENST00000354249.4	-	3	574	c.205C>T	c.(205-207)Ctc>Ttc	p.L69F	TBL3_ENST00000568546.1_3'UTR|NOXO1_ENST00000566005.1_Missense_Mutation_p.L69F|NOXO1_ENST00000356120.4_Missense_Mutation_p.L70F|NOXO1_ENST00000397280.4_Missense_Mutation_p.L70F	NM_001267721.1|NM_144603.3|NM_172167.2|NM_172168.2	NP_001254650.1|NP_653204.1|NP_751907.1|NP_751908.1	Q8NFA2	NOXO1_HUMAN	NADPH oxidase organizer 1	70	PX.				cell communication|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst	NADPH oxidase complex	enzyme binding|phosphatidylinositol binding|superoxide-generating NADPH oxidase activator activity			lung(2)	2						AGCTTTGGGAGAACGCGGTCA	0.667000													8	10					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	621716	621716	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:621716C>A	ENST00000588649.2	-	10	2066	c.1982G>T	c.(1981-1983)gGt>gTt	p.G661V		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	661					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGAAAGCACCAGAGTGCGG	0.682000													6	17					0.00116845	0.0012159	1	1	0
CTSB	1508	broad.mit.edu	37	8	11703277	11703277	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:11703277C>T	ENST00000353047.6	-	9	1068	c.815G>A	c.(814-816)gGa>gAa	p.G272E	CTSB_ENST00000533455.1_Missense_Mutation_p.G272E|CTSB_ENST00000415599.2_3'UTR|CTSB_ENST00000534510.1_Missense_Mutation_p.G272E|CTSB_ENST00000531089.1_Missense_Mutation_p.G272E|CTSB_ENST00000434271.1_Missense_Mutation_p.G272E|CTSB_ENST00000453527.2_Missense_Mutation_p.G272E|CTSB_ENST00000345125.3_Missense_Mutation_p.G272E|CTSB_ENST00000530640.2_Missense_Mutation_p.G272E	NM_001908.3	NP_001899.1	P07858	CATB_HUMAN	cathepsin B	272					proteolysis|regulation of apoptosis|regulation of catalytic activity	lysosome|melanosome	cysteine-type endopeptidase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(1)	16	all_epithelial(15;0.205)		STAD - Stomach adenocarcinoma(15;0.00546)	COAD - Colon adenocarcinoma(149;0.184)		CATCATCTCTCCGGTGACGTG	0.617000													7	31					0	0	1	0	0
CLCA4	22802	broad.mit.edu	37	1	87033222	87033222	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:87033222A>G	ENST00000370563.3	+	7	1112	c.1070A>G	c.(1069-1071)aAt>aGt	p.N357S	CLCA4_ENST00000263723.5_Missense_Mutation_p.N70S	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	357	VWFA.					apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		ACTATTGTAAATAAGCTAATC	0.403000													17	64					0	0	1	0	0
F10	2159	broad.mit.edu	37	13	113798232	113798232	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr13:113798232C>A	ENST00000375559.3	+	6	608	c.570C>A	c.(568-570)agC>agA	p.S190R	F10_ENST00000375551.3_Missense_Mutation_p.S190R|F10_ENST00000409306.1_Missense_Mutation_p.S190R	NM_000504.3	NP_000495.1	P00742	FA10_HUMAN	coagulation factor X	190					blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of cell migration|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen	calcium ion binding|phospholipid binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(4)|lung(10)|pancreas(1)|stomach(1)	18	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.113)|all_lung(25;0.0364)|all_epithelial(44;0.0373)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0805)|Epithelial(84;0.231)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Enoxaparin(DB01225)|Heparin(DB01109)|Menadione(DB00170)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCACCAGCAGCAGCGGGGAGG	0.627000													7	67					0.000157383	0.000166102	1	1	0
CDKN2A	1029	broad.mit.edu	37	9	21994145	21994145	+	Silent	SNP	T	T	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:21994145T>C	ENST00000579755.1	-	1	478	c.186A>G	c.(184-186)agA>agG	p.R62R	CDKN2A_ENST00000361570.3_Silent_p.R103R|CDKN2A_ENST00000498628.2_Intron|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000494262.1_Intron|CDKN2A_ENST00000530628.2_Silent_p.R62R|CDKN2A_ENST00000470819.2_Intron			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	39			EL -> DV.|L -> P (in CMM2).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(198)|p.0(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TACCTGGTCTTCTAGGAAGCG	0.607000		17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			3	20					0	0	1	0	0
MGAT4B	11282	broad.mit.edu	37	5	179227062	179227062	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:179227062C>T	ENST00000337755.5	-	7	1733	c.847G>A	c.(847-849)Gat>Aat	p.D283N	MGAT4B_ENST00000292591.7_Missense_Mutation_p.D268N	NM_054013.3	NP_463459.1	Q9UQ53	MGT4B_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B	268					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	13	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACGATGTCATCCTCCAGCTGC	0.637000													14	58					0	0	1	0	0
OFD1	8481	broad.mit.edu	37	X	13764992	13764992	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chrX:13764992G>C	ENST00000380567.1	+	9	1200	c.328G>C	c.(328-330)Gaa>Caa	p.E110Q	OFD1_ENST00000398395.3_Missense_Mutation_p.E250Q|OFD1_ENST00000340096.6_Missense_Mutation_p.E250Q|OFD1_ENST00000490265.1_3'UTR|OFD1_ENST00000380550.3_Missense_Mutation_p.E250Q			O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	250					cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	25						GAATGATTTTGAAAAAGCTTG	0.328000													11	36					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52489697	52489697	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:52489697G>A	ENST00000345716.4	+	1	174	c.40G>A	c.(40-42)Gag>Aag	p.E14K	NISCH_ENST00000420808.2_Missense_Mutation_p.E14K|NISCH_ENST00000488380.1_Missense_Mutation_p.E14K|NISCH_ENST00000479054.1_Missense_Mutation_p.E14K	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	14	Necessary for binding to phosphoinositide-3-P; not sufficient for targeting to endosomes.|PX.				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		GCGGGAAGCCGAGCCGGCCAA	0.731000													8	17					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185988694	185988694	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:185988694C>T	ENST00000271588.4	+	35	5721	c.5492C>T	c.(5491-5493)tCa>tTa	p.S1831L	HMCN1_ENST00000367492.2_Missense_Mutation_p.S1831L	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1831	Ig-like C2-type 16.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ATCAAGTCCTCAGGCCTTTCT	0.418000													24	202					0	0	1	0	0
PSMD13	5719	broad.mit.edu	37	11	251591	251591	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:251591G>A	ENST00000532097.1	+	11	1387	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	PSMD13_ENST00000532025.1_3'UTR|PSMD13_ENST00000431206.2_Missense_Mutation_p.E297K|PSMD13_ENST00000352303.5_Intron	NM_002817.3	NP_002808.3	Q9UNM6	PSD13_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	295	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding			NS(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	10		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.79e-27)|Epithelial(43;4e-26)|OV - Ovarian serous cystadenocarcinoma(40;6.02e-21)|BRCA - Breast invasive adenocarcinoma(625;3.93e-05)|Lung(200;0.112)|LUSC - Lung squamous cell carcinoma(625;0.129)		CACTTTTGAAGAAATTGCCAA	0.388000													7	64					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1061793	1061793	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:1061793C>T	ENST00000263094.6	+	41	5707	c.5476C>T	c.(5476-5478)Ctg>Ttg	p.L1826L	ABCA7_ENST00000435683.2_Silent_p.L1688L|ABCA7_ENST00000433129.1_Silent_p.L1826L	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1826	ABC transporter 2.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTTGGGCTGCTGGGTGTGAA	0.572000													11	34					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237947556	237947556	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:237947556G>C	ENST00000366574.2	+	90	12861	c.12544G>C	c.(12544-12546)Gag>Cag	p.E4182Q	RYR2_ENST00000360064.6_Missense_Mutation_p.E4188Q|RYR2_ENST00000542537.1_Missense_Mutation_p.E4166Q	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4182					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CGAAGGCGGAGAGAAAGAGAA	0.502000													20	150					0	0	1	0	0
XPR1	9213	broad.mit.edu	37	1	180804096	180804096	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:180804096G>T	ENST00000367590.4	+	10	1419	c.1221G>T	c.(1219-1221)ctG>ctT	p.L407L	XPR1_ENST00000367589.3_Silent_p.L407L	NM_004736.3	NP_004727.2	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor 1	407						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	35						CAGTGATACTGATGGACCTGG	0.428000													22	104					2.70639e-06	2.94846e-06	1	1	0
TMEM196	256130	broad.mit.edu	37	7	19765303	19765303	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:19765303G>T	ENST00000405844.1	-	3	988	c.293C>A	c.(292-294)tCc>tAc	p.S98Y	TMEM196_ENST00000405764.3_Missense_Mutation_p.S98Y|TMEM196_ENST00000493519.1_Missense_Mutation_p.S30Y|TMEM196_ENST00000433641.1_Missense_Mutation_p.S30Y|TMEM196_ENST00000422233.1_Missense_Mutation_p.S30Y			Q5HYL7	TM196_HUMAN	transmembrane protein 196	104						integral to membrane				breast(1)|large_intestine(1)|lung(4)	6						GTATAGGGAGGAAGTTTTCTT	0.502000													9	88					2.17888e-05	2.32936e-05	1	1	0
KIF14	9928	broad.mit.edu	37	1	200587553	200587553	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:200587553G>A	ENST00000367350.4	-	2	737	c.299C>T	c.(298-300)tCa>tTa	p.S100L		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	100	Required for PRC1-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						AAGCAAAGATGATTCTTTGTT	0.408000													35	147					0	0	1	0	0
FBXO47	494188	broad.mit.edu	37	17	37107915	37107915	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:37107915C>G	ENST00000378079.2	-	6	734	c.535G>C	c.(535-537)Gag>Cag	p.E179Q		NM_001008777.2	NP_001008777.2	Q5MNV8	FBX47_HUMAN	F-box protein 47	179										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	20						CGATGGCACTCAAGTTCATCC	0.398000													13	49					0	0	1	0	0
PLXND1	23129	broad.mit.edu	37	3	129304863	129304863	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:129304863C>T	ENST00000393239.1	-	5	1961	c.1783G>A	c.(1783-1785)Gag>Aag	p.E595K	PLXND1_ENST00000324093.4_Missense_Mutation_p.E595K			Q9Y4D7	PLXD1_HUMAN	plexin D1	595					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CTGGGGCCCTCGCTGGCACTG	0.657000													33	110					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304772	102304772	+	RNA	SNP	T	T	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:102304772T>C	ENST00000561463.1	+	0	12818																											CACAGCGGCGTGACGAGACTC	0.587000													3	23					0	0	1	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414844	14414844	+	RNA	SNP	T	T	C	rs148060711	by1000genomes	TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr21:14414844T>C	ENST00000507941.1	+	0	95																											ACTGGGCCTGTGCCAATGGCC	0.433000													4	63					0	0	1	0	0
SYT16	83851	broad.mit.edu	37	14	62536486	62536486	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr14:62536486C>T	ENST00000430451.2	+	2	886	c.689C>T	c.(688-690)tCg>tTg	p.S230L	RP11-355I22.5_ENST00000553990.1_lincRNA|SYT16_ENST00000446982.2_Missense_Mutation_p.S230L	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	230										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TTCAGCCGTTCGTTGTTGACA	0.483000													10	103					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15961826	15961826	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:15961826T>A	ENST00000268712.3	-	38	6226	c.5969A>T	c.(5968-5970)cAg>cTg	p.Q1990L	NCOR1_ENST00000395851.1_Missense_Mutation_p.Q1887L|NCOR1_ENST00000395857.3_Missense_Mutation_p.Q574L	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1990	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTGATAGGTCTGCAGTTTCTC	0.418000													17	142					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6185633	6185633	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:6185633C>G	ENST00000262450.3	-	28	4310	c.4211G>C	c.(4210-4212)aGg>aCg	p.R1404T	CHD5_ENST00000378021.1_Missense_Mutation_p.R261T	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1404					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GGGCTTGTCCCTGTCACTCTT	0.642000													3	13					0	0	1	0	0
GABRA4	2557	broad.mit.edu	37	4	46930564	46930564	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:46930564G>A	ENST00000264318.3	-	9	2325	c.1343C>T	c.(1342-1344)gCa>gTa	p.A448V		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	448					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAGTGCTCTTGCTGCAGATAT	0.463000													24	83					0	0	1	0	0
KDM4D	55693	broad.mit.edu	37	11	94731557	94731557	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:94731557G>C	ENST00000335080.5	+	3	1853	c.1021G>C	c.(1021-1023)Gac>Cac	p.D341H	KDM4D_ENST00000536741.1_Missense_Mutation_p.D341H	NM_018039.2	NP_060509.2	Q6B0I6	KDM4D_HUMAN	lysine (K)-specific demethylase 4D	341					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						ACGTGGGCAAGACCGGGCAGT	0.602000													5	65					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62045711	62045711	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:62045711C>T	ENST00000435607.1	-	6	784	c.708G>A	c.(706-708)ctG>ctA	p.L236L	SCN4A_ENST00000578147.1_Silent_p.L236L	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	236					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	CGATCGTCTTCAGCCCTGACC	0.602000													15	54					0	0	1	0	0
MSANTD3-TMEFF1	100526694	broad.mit.edu	37	9	103271335	103271335	+	Nonsense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:103271335C>G	ENST00000502978.1	+	3	245	c.245C>G	c.(244-246)tCa>tGa	p.S82*	TMEFF1_ENST00000374879.4_Missense_Mutation_p.Q119E|TMEFF1_ENST00000334943.6_Missense_Mutation_p.Q80E	NM_001198812.1	NP_001185741.1	Q8IYR6	TEFF1_HUMAN		0					multicellular organismal development	integral to membrane|plasma membrane											GGACACTTATCAAAATGAATG	0.363000													13	75					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166854585	166854585	+	Missense_Mutation	SNP	C	C	A	rs121917996		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:166854585C>A	ENST00000423058.2	-	23	4456	c.4439G>T	c.(4438-4440)gGt>gTt	p.G1480V	AC010127.3_ENST00000597623.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.G1452V|SCN1A_ENST00000303395.4_Missense_Mutation_p.G1480V|SCN1A_ENST00000375405.3_Missense_Mutation_p.G1469V|AC010127.3_ENST00000595647.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1480			G -> V (in a patient with myoclonic astatic epilepsy; dbSNP:rs121917996).			voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TATGATGACACCAATAAACAG	0.343000													7	80					2.0095e-06	2.19245e-06	1	1	0
FAM194A	131831	broad.mit.edu	37	3	150377805	150377805	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:150377805C>A	ENST00000295910.6	-	14	1918	c.1866G>T	c.(1864-1866)tgG>tgT	p.W622C	FAM194A_ENST00000491361.1_Missense_Mutation_p.W476C	NM_152394.3	NP_689607.2	Q7L0X2	F194A_HUMAN	family with sequence similarity 194, member A	622										NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						TTAATTTTTCCCAAACCTGGC	0.378000													26	115					4.87955e-14	5.99258e-14	1	1	0
QTRT1	81890	broad.mit.edu	37	19	10812882	10812882	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:10812882G>A	ENST00000250237.5	+	3	413	c.403G>A	c.(403-405)Gag>Aag	p.E135K	QTRT1_ENST00000585885.1_3'UTR	NM_031209.2	NP_112486.1	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	135					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			CGACGGCAATGAGACCCTGCT	0.632000													7	57					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101510536	101510536	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:101510536G>A	ENST00000392979.3	+	24	2786	c.2425G>A	c.(2425-2427)Gat>Aat	p.D809N	ANO4_ENST00000299222.9_Missense_Mutation_p.D364N|ANO4_ENST00000550015.1_Missense_Mutation_p.D364N|ANO4_ENST00000392977.3_Missense_Mutation_p.D844N	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	844						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						GCCTGAATCTGATGGCAGTGA	0.532000										HNSCC(74;0.22)			38	144					0	0	1	0	0
WDR88	126248	broad.mit.edu	37	19	33639745	33639745	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:33639745C>T	ENST00000361680.2	+	5	686	c.608C>T	c.(607-609)tCa>tTa	p.S203L	WDR88_ENST00000355868.3_Missense_Mutation_p.S203L			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	203										breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					TACGTGGTCTCAGGCTTCGAC	0.478000													49	164					0	0	1	0	0
MTHFD1L	25902	broad.mit.edu	37	6	151331058	151331058	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:151331058G>T	ENST00000367321.3	+	21	2503	c.2229G>T	c.(2227-2229)acG>acT	p.T743T	MTHFD1L_ENST00000478643.1_3'UTR	NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	743	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		TAGTGGCAACGGTGCGAGCTC	0.498000													14	45					4.36969e-10	5.12904e-10	1	1	0
SYT7	9066	broad.mit.edu	37	11	61300491	61300491	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:61300491G>A	ENST00000263846.4	-	4	648	c.321C>T	c.(319-321)ctC>ctT	p.L107L	SYT7_ENST00000540831.1_5'UTR|SYT7_ENST00000535826.1_Silent_p.L226L|SYT7_ENST00000542836.1_Silent_p.L151L|SYT7_ENST00000539008.1_Silent_p.L390L|SYT7_ENST00000540677.1_Silent_p.L182L|SYT7_ENST00000542670.1_Silent_p.L315L	NM_004200.3	NP_004191.2	O43581	SYT7_HUMAN	synaptotagmin VII	107						cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			kidney(2)|large_intestine(3)|lung(4)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						GGGAGTTGACGAGGTCTGAGA	0.647000													15	70					0	0	1	0	0
FCAR	2204	broad.mit.edu	37	19	55401057	55401057	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:55401057T>A	ENST00000355524.3	+	5	702	c.692T>A	c.(691-693)aTg>aAg	p.M231K	FCAR_ENST00000391726.3_Missense_Mutation_p.M123K|FCAR_ENST00000391723.3_Missense_Mutation_p.H194Q|FCAR_ENST00000353758.4_Missense_Mutation_p.M122K|FCAR_ENST00000359272.4_Missense_Mutation_p.M219K|FCAR_ENST00000391725.3_Missense_Mutation_p.M209K|FCAR_ENST00000345937.4_Missense_Mutation_p.M135K|FCAR_ENST00000391724.3_Missense_Mutation_p.M197K|FCAR_ENST00000482092.2_3'UTR	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	231					immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		TTGATCCGCATGGCCGTGGCA	0.527000													94	365					0	0	1	0	0
LMNB2	84823	broad.mit.edu	37	19	2444431	2444431	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:2444431C>T	ENST00000325327.3	-	2	434	c.372G>A	c.(370-372)ctG>ctA	p.L124L	LMNB2_ENST00000582871.1_Silent_p.L104L			Q03252	LMNB2_HUMAN	lamin B2	104	Coil 1B.|Rod.					nuclear inner membrane	structural molecule activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACTCTGCCCTCAGCTTCCCAA	0.652000													18	26					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82808185	82808185	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:82808185G>A	ENST00000265077.3	+	6	1577	c.1012G>A	c.(1012-1014)Gat>Aat	p.D338N	VCAN_ENST00000502527.2_Missense_Mutation_p.D338N|VCAN_ENST00000343200.5_Missense_Mutation_p.D338N|VCAN_ENST00000342785.4_Missense_Mutation_p.D338N|VCAN_ENST00000513984.1_Missense_Mutation_p.D338N|VCAN_ENST00000512590.2_Missense_Mutation_p.D290N	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	338	Link 2.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CCCTCCCCCTGATAGCAGATT	0.458000													9	45					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57395228	57395228	+	Missense_Mutation	SNP	G	G	A	rs61737417	byFrequency	TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:57395228G>A	ENST00000543257.1	-	13	2035	c.1469C>T	c.(1468-1470)aCc>aTc	p.T490I	C8B_ENST00000535057.1_Missense_Mutation_p.T480I|C8B_ENST00000371237.4_Missense_Mutation_p.T542I	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	542	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						ATCAATGGGGGTATCTATAAG	0.433000													4	59					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531707	50531707	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:50531707C>G	ENST00000374144.3	+	3	1405	c.1117C>G	c.(1117-1119)Caa>Gaa	p.Q373E	C10orf71_ENST00000323868.4_Missense_Mutation_p.Q373E			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	373										endometrium(1)	1						ACCTGATTCTCAAGAGAAGCC	0.512000													5	58					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23762203	23762203	+	Silent	SNP	A	A	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:23762203A>T	ENST00000397312.2	-	2	304	c.30T>A	c.(28-30)acT>acA	p.T10T	ELAVL2_ENST00000544538.1_Silent_p.T10T|ELAVL2_ENST00000380117.1_Silent_p.T10T|ELAVL2_ENST00000223951.6_Silent_p.T10T|ELAVL2_ENST00000380110.4_Silent_p.T39T	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	10					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TGTTATTGCAAGTTGGCCCAT	0.403000													57	227					0	0	1	0	0
FADD	8772	broad.mit.edu	37	11	70052393	70052393	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:70052393C>G	ENST00000301838.4	+	2	738	c.441C>G	c.(439-441)atC>atG	p.I147M		NM_003824.3	NP_003815.1	Q13158	FADD_HUMAN	Fas (TNFRSF6)-associated via death domain	147	Death.				activation of caspase activity|activation of pro-apoptotic gene products|cellular response to mechanical stimulus|defense response to virus|induction of apoptosis via death domain receptors|innate immune response|interspecies interaction between organisms|necrotic cell death|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|signal transduction	cytosol	death receptor binding|identical protein binding			endometrium(1)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(2)	9	Esophageal squamous(2;1.19e-45)		LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CACTGAGAATCTGGAAGAACA	0.577000													8	26					0	0	1	0	0
API5	8539	broad.mit.edu	37	11	43349359	43349359	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:43349359G>C	ENST00000378852.3	+	8	1001	c.876G>C	c.(874-876)gaG>gaC	p.E292D	API5_ENST00000534600.1_Missense_Mutation_p.E292D|API5_ENST00000531273.1_Missense_Mutation_p.E292D|API5_ENST00000420461.2_Missense_Mutation_p.E238D|API5_ENST00000455725.2_Missense_Mutation_p.E281D|API5_ENST00000534695.1_Intron	NM_001142930.1|NM_006595.3	NP_001136402.1|NP_006586.1	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5	292					anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20						TGTTGGCGGAGATGAGTTCAT	0.303000													14	52					0	0	1	0	0
ZRANB2	9406	broad.mit.edu	37	1	71532463	71532463	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:71532463C>T	ENST00000370920.3	-	9	1226	c.925G>A	c.(925-927)Gaa>Aaa	p.E309K	ZRANB2_ENST00000477096.1_5'UTR|ZRANB2_ENST00000254821.6_Missense_Mutation_p.E309K|ZRANB2-AS1_ENST00000450461.1_RNA|ZRANB2-AS1_ENST00000426999.1_RNA	NM_203350.2	NP_976225.1	O95218	ZRAB2_HUMAN	zinc finger, RAN-binding domain containing 2	309	Required for nuclear targeting.				mRNA processing|RNA splicing	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|stomach(1)	15						CCAAACCTTTCGGGTGACCGT	0.368000													8	112					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54824447	54824447	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:54824447C>T	ENST00000243911.2	+	1	660	c.548C>T	c.(547-549)tCg>tTg	p.S183L		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	220			I -> N (associated with susceptibility to obesity; completely lacks signaling in response to agonist stimulation; coexpression of the wild-type and the mutant receptor shows that it does not exert dominant-negative activity on wild- type).		activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			ATCGTCTACTCGGAGAGCAAA	0.572000													41	106					0	0	1	0	0
ACTR5	79913	broad.mit.edu	37	20	37384544	37384544	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:37384544G>A	ENST00000243903.4	+	5	1075	c.1038G>A	c.(1036-1038)ctG>ctA	p.L346L		NM_024855.3	NP_079131.3	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog (yeast)	346					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding			kidney(2)|large_intestine(2)|liver(1)|lung(5)|skin(2)	12		Myeloproliferative disorder(115;0.00878)				ACAAAGCTCTGATAGAGCTGA	0.478000													35	87					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231150529	231150529	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:231150529G>C	ENST00000392045.3	+	17	1741	c.1627G>C	c.(1627-1629)Gac>Cac	p.D543H	SP140_ENST00000350136.5_Missense_Mutation_p.D412H|SP140_ENST00000486687.2_Missense_Mutation_p.D467H|SP140_ENST00000417495.3_Missense_Mutation_p.D429H|SP140_ENST00000420434.3_Missense_Mutation_p.D516H|SP140_ENST00000343805.6_Missense_Mutation_p.D483H	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	543					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GAATCTGAAAGACCTTTCCAA	0.453000													20	92					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38211743	38211743	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr13:38211743G>A	ENST00000379705.3	-	11	3088	c.2231C>T	c.(2230-2232)tCt>tTt	p.S744F	TRPC4_ENST00000358477.2_Missense_Mutation_p.S744F|TRPC4_ENST00000355779.2_Intron|TRPC4_ENST00000379679.1_Missense_Mutation_p.S571F|TRPC4_ENST00000447043.1_Intron|TRPC4_ENST00000338947.5_Missense_Mutation_p.S571F|TRPC4_ENST00000379681.3_Missense_Mutation_p.S749F|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000379673.2_Missense_Mutation_p.S679F			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	744	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GCGGAAACTAGAAATGTCTTG	0.378000													11	59					0	0	1	0	0
DIRAS3	9077	broad.mit.edu	37	1	68512815	68512815	+	Nonsense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:68512815T>A	ENST00000370981.1	-	4	802	c.166A>T	c.(166-168)Aag>Tag	p.K56*	GNG12-AS1_ENST00000413628.1_RNA|GNG12-AS1_ENST00000420587.1_RNA|DIRAS3_ENST00000395201.1_Nonsense_Mutation_p.K56*			O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	56					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						CTCGCCCACTTGTGCAGCAGC	0.582000													36	102					0	0	1	0	0
LRRC23	10233	broad.mit.edu	37	12	7023076	7023076	+	Nonsense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:7023076C>G	ENST00000429740.1	+	4	512	c.512C>G	c.(511-513)tCa>tGa	p.S171*	LRRC23_ENST00000007969.8_3'UTR|LRRC23_ENST00000323702.5_Missense_Mutation_p.F260L|LRRC23_ENST00000436789.1_Missense_Mutation_p.Q215E|LRRC23_ENST00000443597.2_3'UTR			Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23	0										NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	13						CGCTGGCCTTCAGACCTGATC	0.537000													24	115					0	0	1	0	0
GAP43	2596	broad.mit.edu	37	3	115395012	115395012	+	Silent	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:115395012T>A	ENST00000393780.3	+	3	759	c.291T>A	c.(289-291)gcT>gcA	p.A97A	GAP43_ENST00000305124.6_Silent_p.A61A	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	61					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		ATGTCCAAGCTGCTGAGGCTG	0.507000													15	56					0	0	1	0	0
SOAT1	6646	broad.mit.edu	37	1	179316742	179316742	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:179316742G>A	ENST00000367619.3	+	12	1268	c.1125G>A	c.(1123-1125)ctG>ctA	p.L375L	SOAT1_ENST00000540564.1_Silent_p.L317L|SOAT1_ENST00000539888.1_Silent_p.L310L|SOAT1_ENST00000535686.1_Silent_p.L111L	NM_003101.5	NP_003092.4	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	375					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|stomach(1)	20					Ezetimibe(DB00973)|Hesperetin(DB01094)	TAGGTGTGCTGATTCTCTTCC	0.343000													22	90					0	0	1	0	0
FAM26F	441168	broad.mit.edu	37	6	116784533	116784533	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:116784533C>T	ENST00000368605.1	+	3	708	c.613C>T	c.(613-615)Ctg>Ttg	p.L205L	FAM26F_ENST00000368606.3_Silent_p.L33L|RP1-93H18.6_ENST00000476099.1_RNA	NM_001010919.1	NP_001010919.1	Q5R3K3	FA26F_HUMAN	family with sequence similarity 26, member F	205						integral to membrane				large_intestine(2)|lung(1)	3				GBM - Glioblastoma multiforme(226;0.0402)|all cancers(137;0.0627)|OV - Ovarian serous cystadenocarcinoma(136;0.0655)|Epithelial(106;0.231)		AGTTAGTTTTCTGCAGCTGAA	0.388000													37	82					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23913868	23913868	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr13:23913868G>C	ENST00000382298.3	-	10	4735	c.4147C>G	c.(4147-4149)Cat>Gat	p.H1383D	SACS_ENST00000402364.1_Missense_Mutation_p.H633D|SACS_ENST00000382292.3_Missense_Mutation_p.H1383D	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1383					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TTTTTGCTATGATGTATAGGA	0.348000													31	87					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13902205	13902205	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:13902205G>C	ENST00000265104.4	-	13	1791	c.1687C>G	c.(1687-1689)Caa>Gaa	p.Q563E		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	563	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.Q563E(1)		NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTTGTGTTTTGAATCTTTGCA	0.289000									Kartagener syndrome				3	24					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171250035	171250035	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:171250035C>T	ENST00000354841.4	+	5	869	c.738C>T	c.(736-738)tcC>tcT	p.S246S	FMO1_ENST00000367750.3_Silent_p.S246S|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000402921.2_Silent_p.S183S			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	246					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGAGAAATTCCCTCCCAACCC	0.468000													30	126					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11809056	11809056	+	Silent	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:11809056G>C	ENST00000262442.3	+	61	11747	c.11679G>C	c.(11677-11679)tcG>tcC	p.S3893S	DNAH9_ENST00000454412.2_Silent_p.S3893S|DNAH9_ENST00000396001.2_Silent_p.S205S	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3893	AAA 6 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTGAAGAATCGGGACCAGCCA	0.473000													15	52					0	0	1	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51656418	51656418	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:51656418C>T	ENST00000317643.6	+	7	1389	c.1320C>T	c.(1318-1320)ctC>ctT	p.L440L	CTD-3187F8.14_ENST00000600074.1_RNA|SIGLEC7_ENST00000600577.1_3'UTR|SIGLEC7_ENST00000305628.7_Silent_p.L347L	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	440					cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		ATGCACCCCTCAGCTTTCATA	0.537000													21	84					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103197602	103197602	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:103197602G>T	ENST00000424685.2	-	38	5778	c.5619C>A	c.(5617-5619)acC>acA	p.T1873T	RELN_ENST00000343529.5_Silent_p.T1873T|RELN_ENST00000428762.1_Silent_p.T1873T			P78509	RELN_HUMAN	reelin	1873					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.T1873T(1)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATCTCTCTGGGGTACCTAGGA	0.378000													12	67					1.61879e-10	1.9031e-10	1	1	0
GBGT1	26301	broad.mit.edu	37	9	136029195	136029195	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:136029195C>G	ENST00000372040.3	-	7	1124	c.813G>C	c.(811-813)agG>agC	p.R271S	GBGT1_ENST00000372043.3_Missense_Mutation_p.G265A|RALGDS_ENST00000542690.1_Intron|GBGT1_ENST00000472281.1_5'UTR|GBGT1_ENST00000540636.1_Missense_Mutation_p.R254S					globoside alpha-1,3-N-acetylgalactosaminyltransferase 1											breast(2)|endometrium(1)|kidney(4)|lung(2)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(145;3.49e-06)|Epithelial(140;2.59e-05)		ACTCATATACCCTGGCCACCT	0.592000													29	88					0	0	1	0	0
PPDPF	79144	broad.mit.edu	37	20	62153120	62153120	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:62153120C>G	ENST00000370179.3	+	4	429	c.233C>G	c.(232-234)tCg>tGg	p.S78W	PPDPF_ENST00000473620.1_3'UTR|PPDPF_ENST00000370177.1_Missense_Mutation_p.S104W	NM_024299.2	NP_077275.1	Q9H3Y8	PPDPF_HUMAN	pancreatic progenitor cell differentiation and proliferation factor	78					cell differentiation|multicellular organismal development					kidney(1)|lung(2)|ovary(1)	4						GCAGAGCACTCGGAACCTCCC	0.677000													5	35					0	0	1	0	0
ASPH	444	broad.mit.edu	37	8	62475342	62475342	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:62475342C>G	ENST00000541428.1	-	18	1471	c.1311G>C	c.(1309-1311)ttG>ttC	p.L437F	ASPH_ENST00000379454.4_Missense_Mutation_p.L466F	NM_001164750.1	NP_001158222.1	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase	466					muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			breast(1)|cervix(1)|endometrium(5)|large_intestine(5)|lung(16)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	TATCTCCTATCAAGAGGTATC	0.368000													22	99					0	0	1	0	0
ATP5C1	509	broad.mit.edu	37	10	7848938	7848938	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:7848938G>A	ENST00000356708.7	+	9	971	c.890_splice	c.e9-1	p.D298_splice	ATP5C1_ENST00000335698.4_Intron|ATP5C1_ENST00000493053.1_3'UTR	NM_001001973.1	NP_001001973.1	P36542	ATPG_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	298					oxidative phosphorylation|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(2)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	16						AATAACCAGGGATTAATGAAA	0.338000													8	49					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65907168	65907168	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:65907168A>T	ENST00000321892.4	+	13	3607	c.3546A>T	c.(3544-3546)aaA>aaT	p.K1182N	BPTF_ENST00000424123.3_Missense_Mutation_p.K1043N|BPTF_ENST00000306378.6_Missense_Mutation_p.K1056N|BPTF_ENST00000335221.5_Missense_Mutation_p.K1182N			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1182					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			AGAAAACAAAATCATCCAAAC	0.363000													10	51					0	0	1	0	0
RINT1	60561	broad.mit.edu	37	7	105187513	105187513	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:105187513C>G	ENST00000257700.2	+	5	903	c.672C>G	c.(670-672)ctC>ctG	p.L224L		NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	224	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						ATAAAATTCTCAAGGACAAGC	0.373000													8	117					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15850335	15850335	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:15850335C>A	ENST00000338282.6	-	14	1718	c.1612G>T	c.(1612-1614)Gaa>Taa	p.E538*	MYH11_ENST00000396324.3_Nonsense_Mutation_p.E545*|MYH11_ENST00000452625.2_Nonsense_Mutation_p.E545*|MYH11_ENST00000300036.5_Nonsense_Mutation_p.E538*|MYH11_ENST00000576790.1_Nonsense_Mutation_p.E538*	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	538	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						AACCAGCATTCCTCGTCCAGC	0.572000			T	CBFB	AML						OREG0023636	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	41					0.00121646	0.0012641	1	1	0
NOS2	4843	broad.mit.edu	37	17	26105806	26105806	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:26105806C>G	ENST00000313735.6	-	11	1424	c.1191G>C	c.(1189-1191)agG>agC	p.R397S		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	397					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GGCCCATTCTCCTGCCCACTT	0.587000													23	70					0	0	1	0	0
AARS	16	broad.mit.edu	37	16	70301626	70301626	+	Silent	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:70301626G>C	ENST00000261772.8	-	9	1301	c.1158C>G	c.(1156-1158)ctC>ctG	p.L386L		NM_001605.2	NP_001596.2	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	386					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(3)|cervix(2)|endometrium(5)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	GCCCTCTGCTGAGAGTCTTGA	0.517000											OREG0023913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	44					0	0	1	0	0
HBG2	3048	broad.mit.edu	37	11	5275556	5275556	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:5275556C>A	ENST00000380259.2	-	7	1521	c.281G>T	c.(280-282)tGt>tTt	p.C94F	HBG2_ENST00000380252.1_Missense_Mutation_p.C84F|HBG2_ENST00000336906.4_Missense_Mutation_p.C94F					hemoglobin, gamma G											endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	13		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGCTTGTCACAGTGCAGTTC	0.498000													25	126					1.04121e-07	1.17215e-07	1	1	0
SERPINA1	5265	broad.mit.edu	37	14	94849308	94849308	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr14:94849308G>A	ENST00000448921.1	-	4	839	c.267C>T	c.(265-267)tcC>tcT	p.S89S	SERPINA1_ENST00000355814.4_Silent_p.S89S|SERPINA1_ENST00000449399.3_Silent_p.S89S|SERPINA1_ENST00000393088.4_Silent_p.S89S|SERPINA1_ENST00000393087.4_Silent_p.S89S|SERPINA1_ENST00000404814.4_Silent_p.S89S|SERPINA1_ENST00000440909.1_Silent_p.S89S|SERPINA1_ENST00000437397.1_Silent_p.S89S|SERPINA1_ENST00000402629.1_Silent_p.S89S	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	89					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	TGGTCCCCAGGGAGAGCATTG	0.547000													7	95					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87242267	87242267	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:87242267T>G	ENST00000297524.3	-	1	343	c.240A>C	c.(238-240)caA>caC	p.Q80H	SLC7A13_ENST00000419776.2_Missense_Mutation_p.Q80H|SLC7A13_ENST00000520624.1_Intron	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	80						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						GAAAATAGTATTGAGCTCCAC	0.493000													11	51					0	0	1	0	0
KCNJ8	3764	broad.mit.edu	37	12	21926330	21926330	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:21926330A>G	ENST00000240662.2	-	2	566	c.221T>C	c.(220-222)gTc>gCc	p.V74A		NM_004982.3	NP_004973.1	Q15842	IRK8_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 8	74						voltage-gated potassium channel complex				cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28					Levosimendan(DB00922)	GGTAAAGATGACCAGCGTGTG	0.547000											OREG0021704	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	78					0	0	1	0	0
RNF40	9810	broad.mit.edu	37	16	30778076	30778076	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:30778076G>T	ENST00000324685.6	+	11	1743	c.1308G>T	c.(1306-1308)ggG>ggT	p.G436G	RNF40_ENST00000402121.3_Silent_p.G128G|RNF40_ENST00000563683.1_Silent_p.G396G|RNF40_ENST00000357890.5_Silent_p.G336G	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586.1	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	436					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			ACGAGCTGGGGCTGCAGAAGA	0.557000													10	35					1.58986e-06	1.74228e-06	1	1	0
A1CF	29974	broad.mit.edu	37	10	52619632	52619632	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:52619632C>G	ENST00000282641.2	-	3	256	c.69G>C	c.(67-69)ctG>ctC	p.L23L	A1CF_ENST00000395489.2_5'UTR|A1CF_ENST00000373993.1_Silent_p.L23L|A1CF_ENST00000373995.3_5'UTR|A1CF_ENST00000395495.1_Silent_p.L23L|A1CF_ENST00000374001.1_Silent_p.L23L|A1CF_ENST00000373997.3_Silent_p.L23L	NM_138932.2	NP_620310.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	23					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						TGCGCTGGACCAGTGCGCGGA	0.483000													9	49					0	0	1	0	0
IFNGR1	3459	broad.mit.edu	37	6	137519721	137519721	+	Nonsense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:137519721G>C	ENST00000367739.4	-	7	1038	c.917C>G	c.(916-918)tCa>tGa	p.S306*	IFNGR1_ENST00000543628.1_Nonsense_Mutation_p.S278*	NM_000416.2	NP_000407.1	P15260	INGR1_HUMAN	interferon gamma receptor 1	306					regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	18	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	CGTGATGAGTGATACATATTT	0.388000													5	61					0	0	1	0	0
POLA2	23649	broad.mit.edu	37	11	65035009	65035009	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:65035009G>C	ENST00000265465.3	+	3	797	c.266G>C	c.(265-267)gGa>gCa	p.G89A	POLA2_ENST00000541089.1_5'UTR	NM_002689.2	NP_002680.2	Q14181	DPOA2_HUMAN	polymerase (DNA directed), alpha 2, accessory subunit	89					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding			endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	11					Dacarbazine(DB00851)	GGCCATGCAGGAGCTAGAGAC	0.398000													7	64					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13604728	13604728	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:13604728C>A	ENST00000040738.5	-	10	3931	c.3796G>T	c.(3796-3798)Gct>Tct	p.A1266S		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1266							DNA binding	p.A1266S(1)									TCTCCTTGAGCAACATGTTCT	0.408000													12	45					3.07112e-06	3.33115e-06	1	1	0
ZZEF1	23140	broad.mit.edu	37	17	3978714	3978714	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:3978714C>T	ENST00000381638.2	-	22	3368	c.3244G>A	c.(3244-3246)Gag>Aag	p.E1082K		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	1082							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						TGCCAGGTCTCAACATCCAGC	0.463000											OREG0024096	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	69					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43308105	43308105	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:43308105C>T	ENST00000361428.2	-	10	3708	c.3631G>A	c.(3631-3633)Gag>Aag	p.E1211K	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1211	Lys-rich.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TCTTTCTTCTCCTCCTTTGGT	0.498000													25	197					0	0	1	0	0
MEOX1	4222	broad.mit.edu	37	17	41720925	41720925	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:41720925G>T	ENST00000318579.4	-	2	992	c.573C>A	c.(571-573)gcC>gcA	p.A191A	MEOX1_ENST00000329168.3_Intron|MEOX1_ENST00000393661.2_Silent_p.A76A|MEOX1_ENST00000549132.1_Intron	NM_001040002.1|NM_004527.3	NP_001035091.1|NP_004518.1	P50221	MEOX1_HUMAN	mesenchyme homeobox 1	191						nucleus	sequence-specific DNA binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	8		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0753)		AGTTATGATGGGCAAACTCTG	0.612000													3	13					6.4e-05	6.81261e-05	1	1	0
ARHGAP21	57584	broad.mit.edu	37	10	24910189	24910189	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:24910189G>T	ENST00000396432.2	-	9	1121	c.635C>A	c.(634-636)tCa>tAa	p.S212*	ARHGAP21_ENST00000320481.6_5'UTR	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	211					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TGCCATGGCTGATGGGGCAGA	0.507000													15	46					1.02788e-11	1.22587e-11	1	1	0
CDH7	1005	broad.mit.edu	37	18	63477170	63477170	+	Missense_Mutation	SNP	C	C	G	rs143932384		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr18:63477170C>G	ENST00000536984.2	+	3	1135	c.441C>G	c.(439-441)aaC>aaG	p.N147K	CDH7_ENST00000397968.2_Missense_Mutation_p.N147K|CDH7_ENST00000323011.3_Missense_Mutation_p.N147K			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	147	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.N147N(2)		NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				AGGATATCAACGACAATGAAC	0.507000													32	121					0	0	1	0	0
CAND1	55832	broad.mit.edu	37	12	67686403	67686403	+	Splice_Site	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:67686403C>T	ENST00000545606.1	+	3	651	c.212_splice	c.e3-1	p.L72_splice		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	72					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		GTATTACAGTCTTGGTCCTTT	0.333000													5	35					0	0	1	0	0
PRKCZ	5590	broad.mit.edu	37	1	2105377	2105377	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:2105377G>C	ENST00000400921.2	+	11	1461	c.778G>C	c.(778-780)Gag>Cag	p.E260Q	PRKCZ_ENST00000400920.1_Missense_Mutation_p.E260Q|PRKCZ_ENST00000479263.1_3'UTR	NM_001033581.1	NP_001028753.1	Q05513	KPCZ_HUMAN	protein kinase C, zeta	443	Protein kinase.				anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		CCTCATGTTTGAGATGATGGC	0.627000											OREG0013007	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	103					0	0	1	0	0
MAP4K3	8491	broad.mit.edu	37	2	39487861	39487861	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:39487861C>T	ENST00000263881.3	-	29	2518	c.2194G>A	c.(2194-2196)Gaa>Aaa	p.E732K	MAP4K3_ENST00000341681.5_Missense_Mutation_p.E711K|MAP4K3_ENST00000536018.1_Missense_Mutation_p.E285K|MAP4K3_ENST00000437545.1_Missense_Mutation_p.E648K	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3	732	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				TACTCCTGTTCAGGAACTACC	0.373000													4	45					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142459835	142459835	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:142459835G>A	ENST00000486171.1	+	4	470	c.453G>A	c.(451-453)acG>acA	p.T151T	PRSS1_ENST00000311737.7_Silent_p.T137T			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	137	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity	p.T137T(2)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			CCACTGGCACGAAGTGCCTCA	0.552000													21	95					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83847154	83847154	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:83847154G>A	ENST00000349129.2	+	21	3653	c.3393G>A	c.(3391-3393)gtG>gtA	p.V1131V	DOPEY1_ENST00000369739.3_Silent_p.V1122V|DOPEY1_ENST00000237163.5_Silent_p.V1112V	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	1131					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CTGAAACCGTGAATGCCCAAG	0.453000													9	55					0	0	1	0	0
TIMMDC1	51300	broad.mit.edu	37	3	119217754	119217754	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:119217754C>T	ENST00000494664.1	+	1	376	c.174C>T	c.(172-174)ctC>ctT	p.L58L	TIMMDC1_ENST00000493694.1_Silent_p.L58L	NM_016589.3	NP_057673.2	Q9NPL8	TIDC1_HUMAN	translocase of inner mitochondrial membrane domain containing 1	58						integral to membrane|mitochondrial inner membrane	protein transporter activity			autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	15						GGGACCGCCTCCGGGAGCTGT	0.612000													22	93					0	0	1	0	0
PIGQ	9091	broad.mit.edu	37	16	624618	624618	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:624618G>C	ENST00000321878.5	+	2	703	c.544G>C	c.(544-546)Gat>Cat	p.D182H	PIGQ_ENST00000026218.5_Missense_Mutation_p.D182H|PIGQ_ENST00000409527.2_Missense_Mutation_p.D182H|PIGQ_ENST00000470411.2_Missense_Mutation_p.D182H	NM_004204.3	NP_004195.2	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class Q	182					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(780;0.00335)				TGACCGCTTTGATGAGGGCCC	0.697000													4	7					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1902216	1902216	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:1902216C>G	ENST00000358771.4	+	3	764	c.612C>G	c.(610-612)agC>agG	p.S204R	SIRPA_ENST00000356025.3_Missense_Mutation_p.S204R|SIRPA_ENST00000400068.3_Missense_Mutation_p.S204R	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	204	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		TAGGAGAGAGCGTGTCCTACA	0.577000													35	127					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143027941	143027941	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:143027941G>T	ENST00000343257.2	+	8	1017	c.930G>T	c.(928-930)acG>acT	p.T310T	CLCN1_ENST00000495612.1_3'UTR	NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	310					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					TTGCAGCCACGTTCAGCGCCT	0.522000													29	74					1.74197e-06	1.90336e-06	1	1	0
NR1I3	9970	broad.mit.edu	37	1	161200682	161200682	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:161200682C>T	ENST00000367983.4	-	8	1132	c.838G>A	c.(838-840)Gag>Aag	p.E280K	NR1I3_ENST00000515621.1_Missense_Mutation_p.E205K|NR1I3_ENST00000367985.3_Missense_Mutation_p.E246K|NR1I3_ENST00000512372.1_Missense_Mutation_p.E212K|NR1I3_ENST00000511944.1_Missense_Mutation_p.M137I|NR1I3_ENST00000511676.1_Missense_Mutation_p.E251K|NR1I3_ENST00000511748.1_Missense_Mutation_p.M108I|NR1I3_ENST00000508740.1_Missense_Mutation_p.E256K|NR1I3_ENST00000508387.1_Missense_Mutation_p.M108I|NR1I3_ENST00000506209.1_Missense_Mutation_p.E251K|NR1I3_ENST00000442691.2_Missense_Mutation_p.E284K|NR1I3_ENST00000505005.1_Missense_Mutation_p.E241K|NR1I3_ENST00000504010.1_Missense_Mutation_p.E212K|NR1I3_ENST00000502985.1_Missense_Mutation_p.M137I|NR1I3_ENST00000428574.2_Missense_Mutation_p.E285K|NR1I3_ENST00000367981.3_Missense_Mutation_p.E256K|NR1I3_ENST00000367980.2_Missense_Mutation_p.E289K|NR1I3_ENST00000367982.4_Missense_Mutation_p.E284K|NR1I3_ENST00000367984.4_Missense_Mutation_p.E241K|NR1I3_ENST00000479324.1_5'UTR|NR1I3_ENST00000437437.2_Missense_Mutation_p.E251K|NR1I3_ENST00000412844.2_Missense_Mutation_p.E260K|NR1I3_ENST00000367979.2_Missense_Mutation_p.E289K			Q14994	NR1I3_HUMAN	nuclear receptor subfamily 1, group I, member 3	284					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	androgen receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	15	all_cancers(52;1.86e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TGATCAATCTCATCTCTCTGG	0.612000													11	84					0	0	1	0	0
C11orf63	79864	broad.mit.edu	37	11	122774697	122774697	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:122774697G>C	ENST00000227349.2	+	3	706	c.409G>C	c.(409-411)Gag>Cag	p.E137Q	C11orf63_ENST00000531316.1_Missense_Mutation_p.E137Q|C11orf63_ENST00000307257.6_Missense_Mutation_p.E137Q	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	137										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GAGTAAGAAGGAGGAAGGGCA	0.517000													40	185					0	0	1	0	0
COG5	10466	broad.mit.edu	37	7	106851020	106851020	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:106851020G>T	ENST00000393603.2	-	21	2690	c.2419C>A	c.(2419-2421)Cag>Aag	p.Q807K	COG5_ENST00000347053.3_Missense_Mutation_p.Q786K|COG5_ENST00000297135.3_Missense_Mutation_p.Q807K	NM_001161520.1	NP_001154992.1	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5	786					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|skin(4)|stomach(1)	40						TCCAGCCACTGAGAGAAGCGT	0.537000													3	12					0.184627	0.185126	1	1	0
SHANK3	85358	broad.mit.edu	37	22	51137192	51137192	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:51137192G>T	ENST00000414786.2	+	12	1758	c.1531G>T	c.(1531-1533)Gtg>Ttg	p.V511L	SHANK3_ENST00000445220.2_Missense_Mutation_p.V526L|SHANK3_ENST00000262795.3_Missense_Mutation_p.V541L			F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	541										central_nervous_system(1)|endometrium(1)|kidney(1)|lung(5)	8		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		GGCCGACTGCGTGGAGGAAGT	0.652000													3	24					1	1	1	1	0
AASS	10157	broad.mit.edu	37	7	121733190	121733190	+	Missense_Mutation	SNP	G	G	A	rs74882337	byFrequency	TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:121733190G>A	ENST00000393376.1	-	15	1773	c.1678C>T	c.(1678-1680)Cct>Tct	p.P560S	AASS_ENST00000417368.2_Missense_Mutation_p.P560S|AASS_ENST00000473553.1_5'UTR			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	560	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	GCCACAAGAGGGTGCAATACA	0.383000													5	79					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	8976589	8976589	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:8976589G>T	ENST00000397910.4	-	74	42590	c.42387C>A	c.(42385-42387)atC>atA	p.I14129I	MUC16_ENST00000596956.1_5'UTR|MUC16_ENST00000380951.5_Silent_p.I770I	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	14160	SEA 14.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACCTGAGGGAGATCAGTTGGC	0.567000													3	12					0.004672	0.0047814	1	1	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77334339	77334339	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:77334339C>T	ENST00000477717.1	+	2	408	c.173C>T	c.(172-174)cCg>cTg	p.P58L	ST6GALNAC5_ENST00000496845.1_3'UTR	NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	58					protein glycosylation	integral to Golgi membrane	sialyltransferase activity	p.P58L(1)		endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						AGCTCGCAGCCGGCGGCGGAG	0.731000													7	8					0	0	1	0	0
OR11H1	81061	broad.mit.edu	37	22	16449707	16449707	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:16449707G>T	ENST00000252835.4	-	1	98	c.98C>A	c.(97-99)tCt>tAt	p.S33Y		NM_001005239.1	NP_001005239.1	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H, member 1	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)	11	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		CCACTCACAAGAGAAACCTTG	0.413000													20	148					1.69901e-12	2.04597e-12	1	1	0
NES	10763	broad.mit.edu	37	1	156640980	156640980	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:156640980C>T	ENST00000368223.3	-	4	3132	c.3000G>A	c.(2998-3000)ctG>ctA	p.L1000L		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1000	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGTGGCATTCAGCTCTCCCT	0.602000													32	609					0	0	1	0	0
ZNF232	7775	broad.mit.edu	37	17	5009304	5009304	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:5009304C>G	ENST00000250076.3	-	5	1804	c.1150G>C	c.(1150-1152)Gag>Cag	p.E384Q	ZNF232_ENST00000575898.1_Missense_Mutation_p.E375Q|ZNF232_ENST00000416429.2_3'UTR	NM_014519.2	NP_055334.2	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	357					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2)	11						TAGGGCTTCTCTCCTGAGTGA	0.443000													10	63					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179600423	179600423	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:179600423A>G	ENST00000589042.1	-	50	14974	c.14750T>C	c.(14749-14751)gTc>gCc	p.V4917A	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.V4600A|TTN_ENST00000342992.6_Missense_Mutation_p.V3673A|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	4600	Ig-like 29.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGTAACTGTGACTTTTCTGTC	0.408000													13	47					0	0	1	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119134970	119134970	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:119134970C>T	ENST00000264245.4	+	12	4726	c.4194C>T	c.(4192-4194)gtC>gtT	p.V1398V		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	1398					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						ACACATGGGTCACACCAGAAG	0.502000													5	80					0	0	1	0	0
PJA2	9867	broad.mit.edu	37	5	108714262	108714262	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:108714262G>A	ENST00000361189.2	-	4	1165	c.926C>T	c.(925-927)tCt>tTt	p.S309F	PJA2_ENST00000361557.3_Missense_Mutation_p.S309F	NM_014819.4	NP_055634.3	O43164	PJA2_HUMAN	praja ring finger 2, E3 ubiquitin protein ligase	309					long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		CTGTTCAGGAGAACTTCCATG	0.423000													42	184					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139886559	139886559	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:139886559C>T	ENST00000297183.6	+	19	3672	c.3548C>T	c.(3547-3549)tCa>tTa	p.S1183L	ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.S1183L|ANKHD1_ENST00000360839.2_Missense_Mutation_p.S1183L	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAATTAATTCAAGGTATTGC	0.333000													9	129					0	0	1	0	0
ANAPC1	64682	broad.mit.edu	37	2	112592273	112592273	+	Missense_Mutation	SNP	G	G	T	rs3932348		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:112592273G>T	ENST00000341068.3	-	19	3064	c.2292C>A	c.(2290-2292)ttC>ttA	p.F764L		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	764					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						GGTGAAGAACGAAAAAAATTG	0.383000													18	116					2.37509e-13	2.8882e-13	1	1	0
C1orf127	148345	broad.mit.edu	37	1	11015223	11015223	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:11015223C>T	ENST00000377004.4	-	9	798	c.799G>A	c.(799-801)Gag>Aag	p.E267K	C1orf127_ENST00000377008.4_Missense_Mutation_p.E100K	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	118										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		ACTAAGACCTCCGACTCTGGC	0.517000													23	75					0	0	1	0	0
ZNF501	115560	broad.mit.edu	37	3	44776456	44776456	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:44776456G>C	ENST00000396048.2	+	3	980	c.543G>C	c.(541-543)caG>caC	p.Q181H		NM_001258280.1|NM_145044.3	NP_001245209.1|NP_659481.2	Q96CX3	ZN501_HUMAN	zinc finger protein 501	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.00843)|KIRC - Kidney renal clear cell carcinoma(197;0.0463)|Kidney(197;0.0579)		TGCAGCATCAGAGAATTCATT	0.433000													16	67					0	0	1	0	0
ZNF680	340252	broad.mit.edu	37	7	63982111	63982111	+	Nonsense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:63982111T>A	ENST00000309683.6	-	4	1172	c.1021A>T	c.(1021-1023)Aag>Tag	p.K341*		NM_178558.4	NP_848653.2	Q8NEM1	ZN680_HUMAN	zinc finger protein 680	341					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	27		Lung NSC(55;0.118)|all_lung(88;0.243)				TGAATTTTCTTATGTTTAGTA	0.348000													11	43					0	0	1	0	0
TRIM13	10206	broad.mit.edu	37	13	50586697	50586697	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr13:50586697G>C	ENST00000378182.3	+	2	1359	c.621G>C	c.(619-621)atG>atC	p.M207I	TRIM13_ENST00000420995.2_Missense_Mutation_p.M207I|TRIM13_ENST00000356017.4_Missense_Mutation_p.M210I|TRIM13_ENST00000457662.2_Missense_Mutation_p.M207I|TRIM13_ENST00000478111.1_Intron|TRIM13_ENST00000298772.5_Missense_Mutation_p.M210I	NM_001007278.1|NM_005798.3|NM_052811.2|NM_213590.1	NP_001007279.1|NP_005789.2|NP_434698.1|NP_998755.1	O60858	TRI13_HUMAN	tripartite motif containing 13	207					anatomical structure morphogenesis|ER-associated protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination	cytoplasm|endoplasmic reticulum membrane|integral to membrane	protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(5)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.53e-10)|COAD - Colon adenocarcinoma(199;0.205)		TTGAGACCATGAAACTTGCTG	0.388000													13	30					0	0	1	0	0
ATXN2	6311	broad.mit.edu	37	12	111908388	111908388	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:111908388G>C	ENST00000377617.3	-	19	3318	c.3157C>G	c.(3157-3159)Cag>Gag	p.Q1053E	ATXN2_ENST00000550104.1_3'UTR|ATXN2_ENST00000535949.1_Missense_Mutation_p.Q764E|ATXN2_ENST00000389153.4_Missense_Mutation_p.Q790E|ATXN2_ENST00000542287.2_Missense_Mutation_p.Q788E	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	1053	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						GGCACATGCTGAACAAGGGGC	0.468000													24	108					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99771716	99771716	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:99771716C>A	ENST00000370185.3	+	7	1939	c.1442C>A	c.(1441-1443)tCa>tAa	p.S481*	LPPR4_ENST00000370184.1_Nonsense_Mutation_p.S323*|LPPR4_ENST00000457765.1_Nonsense_Mutation_p.S423*	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		481							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		GAAATGAGGTCAAGCTCAGAG	0.517000													33	124					1.08312e-15	1.35027e-15	1	1	0
VPS13B	157680	broad.mit.edu	37	8	100523679	100523679	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:100523679C>T	ENST00000358544.2	+	29	4758	c.4647C>T	c.(4645-4647)gtC>gtT	p.V1549V	VPS13B_ENST00000357162.2_Silent_p.V1524V|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1549					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TGATTTATGTCAACACAAGTG	0.348000													10	55					0	0	1	0	0
SGCB	6443	broad.mit.edu	37	4	52894977	52894977	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:52894977G>T	ENST00000381431.5	-	4	762	c.540C>A	c.(538-540)ttC>ttA	p.F180L	SGCB_ENST00000535450.1_Missense_Mutation_p.F110L	NM_000232.4	NP_000223.1	Q16585	SGCB_HUMAN	sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)	180	Cys-rich.				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma				breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(6)|prostate(1)	17			GBM - Glioblastoma multiforme(4;7.63e-12)|LUSC - Lung squamous cell carcinoma(32;0.00204)			AGTCTGTGCTGAATAAGATAT	0.378000													17	67					2.94398e-08	3.37559e-08	1	1	0
GPR156	165829	broad.mit.edu	37	3	119892253	119892253	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:119892253C>A	ENST00000464295.1	-	9	1443	c.998G>T	c.(997-999)aGc>aTc	p.S333I	GPR156_ENST00000315843.3_Missense_Mutation_p.S333I|GPR156_ENST00000461057.1_Missense_Mutation_p.S329I			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	333						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		GTTGGGAGTGCTGAAATATTT	0.438000													20	80					1.2644e-06	1.38972e-06	1	1	0
RTN1	6252	broad.mit.edu	37	14	60072208	60072208	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr14:60072208C>G	ENST00000267484.5	-	5	2325	c.1990G>C	c.(1990-1992)Gag>Cag	p.E664Q	RTN1_ENST00000342503.4_Missense_Mutation_p.E96Q|RTN1_ENST00000395090.1_Missense_Mutation_p.E81Q|RTN1_ENST00000557422.1_Intron	NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	664	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		AGGGTGATCTCAAGCTCCAAG	0.507000													18	64					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189864209	189864209	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:189864209C>T	ENST00000304636.3	+	31	2305	c.2135C>T	c.(2134-2136)cCt>cTt	p.P712L	COL3A1_ENST00000317840.5_Missense_Mutation_p.P712L	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	712	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GCTGCTGGTCCTCCTGGGCCA	0.473000													26	74					0	0	1	0	0
ZZEF1	23140	broad.mit.edu	37	17	3978564	3978564	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:3978564C>T	ENST00000381638.2	-	22	3518	c.3394G>A	c.(3394-3396)Gaa>Aaa	p.E1132K		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	1132							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						TACCTTTTTTCAGTTTCACAC	0.413000											OREG0024096	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	113					0	0	1	0	0
CNNM1	26507	broad.mit.edu	37	10	101117351	101117351	+	Silent	SNP	G	G	A	rs148043245		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:101117351G>A	ENST00000356713.4	+	2	1945	c.1656G>A	c.(1654-1656)acG>acA	p.T552T	CNNM1_ENST00000446890.1_Silent_p.T481T|CNNM1_ENST00000370534.4_Silent_p.T187T|CNNM1_ENST00000370528.3_Silent_p.T481T	NM_020348.2	NP_065081.2	Q9NRU3	CNNM1_HUMAN	cyclin M1	552	CBS 2.				ion transport	integral to membrane|plasma membrane				NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(5)|ovary(1)|prostate(1)|skin(1)	25		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		GCATTGTCACGCTGGAGGATA	0.473000													15	32					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82333636	82333636	+	Splice_Site	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:82333636G>C	ENST00000376520.4	+	16	2264		c.e16-1		TLE4_ENST00000376534.4_Splice_Site|TLE4_ENST00000376537.4_Splice_Site|TLE4_ENST00000376544.3_Splice_Site|TLE4_ENST00000376552.2_Splice_Site|TLE4_ENST00000265284.6_Splice_Site			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)											breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CATTGCCTTAGAGCATACTCC	0.483000													6	34					0	0	1	0	0
NAPEPLD	222236	broad.mit.edu	37	7	102755612	102755612	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:102755612C>T	ENST00000417955.1	-	4	1105	c.951G>A	c.(949-951)atG>atA	p.M317I	NAPEPLD_ENST00000465647.1_Missense_Mutation_p.M317I|NAPEPLD_ENST00000341533.4_Missense_Mutation_p.M317I|NAPEPLD_ENST00000455523.2_Missense_Mutation_p.M390I|NAPEPLD_ENST00000427257.1_Missense_Mutation_p.M317I			Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	317					phospholipid catabolic process	membrane	metal ion binding			endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						GCTGGTATTTCATAAACCACC	0.358000													13	86					0	0	1	0	0
CDC73	79577	broad.mit.edu	37	1	193218895	193218895	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:193218895C>T	ENST00000367435.3	+	16	1637	c.1453C>T	c.(1453-1455)Ctg>Ttg	p.L485L	CDC73_ENST00000477868.1_3'UTR	NM_024529.4	NP_078805.3	Q6P1J9	CDC73_HUMAN	cell division cycle 73	485					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(14)|ovary(1)|pancreas(1)|parathyroid(51)|skin(1)|upper_aerodigestive_tract(1)	87						TGAAGTTCGTCTGGATCCAAA	0.338000													14	106					0	0	1	0	0
SBF1	6305	broad.mit.edu	37	22	50905860	50905860	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:50905860G>A	ENST00000380817.2	-	5	639	c.456C>T	c.(454-456)atC>atT	p.I152I	SBF1_ENST00000348911.6_Silent_p.I153I|SBF1_ENST00000390679.3_Silent_p.I152I	NM_002972.2	NP_002963.2	O95248	MTMR5_HUMAN	SET binding factor 1	152	DENN.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(8)|large_intestine(3)|lung(18)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	43		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		GGATGGCATAGATGAGGCCAA	0.647000													7	98					0	0	1	0	0
FAF2	23197	broad.mit.edu	37	5	175927109	175927109	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:175927109C>T	ENST00000261942.6	+	10	1170	c.1117C>T	c.(1117-1119)Cga>Tga	p.R373*		NM_014613.2	NP_055428.1	Q96CS3	FAF2_HUMAN	Fas associated factor family member 2	373	UBX.				response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			breast(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	10						TAATGATTCTCGAGTAGAGAG	0.438000													7	130					0	0	1	0	0
THAP6	152815	broad.mit.edu	37	4	76452281	76452281	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:76452281G>C	ENST00000311638.3	+	5	594	c.526G>C	c.(526-528)Gaa>Caa	p.E176Q	THAP6_ENST00000380837.3_Missense_Mutation_p.E134Q|THAP6_ENST00000502620.1_Intron|THAP6_ENST00000504190.1_Intron|THAP6_ENST00000507556.1_Intron|THAP6_ENST00000507557.1_Intron|THAP6_ENST00000514480.1_Missense_Mutation_p.E176Q|THAP6_ENST00000507885.1_Intron	NM_144721.4	NP_653322.1	Q8TBB0	THAP6_HUMAN	THAP domain containing 6	176						microtubule cytoskeleton	DNA binding|metal ion binding			lung(5)	5			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TTTAGACCGAGAAAAACGTTT	0.388000													21	66					0	0	1	0	0
OR1S2	219958	broad.mit.edu	37	11	57971557	57971557	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:57971557G>C	ENST00000302592.6	-	1	96	c.97C>G	c.(97-99)Cag>Gag	p.Q33E		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				TGTTCAGCCTGGTTGGAGAGT	0.438000													16	102					0	0	1	0	0
GLRX3	10539	broad.mit.edu	37	10	131959182	131959182	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:131959182C>G	ENST00000368644.1	+	4	421	c.399C>G	c.(397-399)ctC>ctG	p.L133L	GLRX3_ENST00000331244.5_Silent_p.L133L	NM_001199868.1	NP_001186797.1	O76003	GLRX3_HUMAN	glutaredoxin 3	133					cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity			endometrium(1)|large_intestine(5)|lung(7)	13		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		AAGAAGATCTCAACCTTCGCT	0.463000													16	81					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46977836	46977836	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:46977836G>A	ENST00000371253.2	-	11	1550	c.1335C>T	c.(1333-1335)taC>taT	p.Y445Y	GPR110_ENST00000449332.2_5'UTR|GPR110_ENST00000283297.5_Silent_p.Y248Y	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	445					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						TCTGATAGCTGTAACCCCTTT	0.443000													6	109					0	0	1	0	0
DCAF13	25879	broad.mit.edu	37	8	104427284	104427284	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:104427284G>A	ENST00000297579.5	+	1	343	c.66G>A	c.(64-66)acG>acA	p.T22T	SLC25A32_ENST00000297578.4_5'UTR|SLC25A32_ENST00000543107.1_5'UTR	NM_015420.6	NP_056235.4	Q9NV06	DCA13_HUMAN	DDB1 and CUL4 associated factor 13	0					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				NS(1)|breast(1)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						CGGGACCAACGAGAGGACTCT	0.687000													4	23					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64393953	64393953	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:64393953C>G	ENST00000265459.6	-	20	4290	c.3829G>C	c.(3829-3831)Gag>Cag	p.E1277Q	NRXN2_ENST00000377559.3_Intron|NRXN2_ENST00000301894.2_Missense_Mutation_p.E231Q|NRXN2_ENST00000409571.1_Missense_Mutation_p.E1270Q|NRXN2_ENST00000377551.1_Missense_Mutation_p.E1277Q	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	1277	Laminin G-like 6.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						AGCAGCCACTCATCTACTACT	0.408000													29	91					0	0	1	0	0
EPHA1	2041	broad.mit.edu	37	7	143096457	143096457	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:143096457G>A	ENST00000275815.3	-	5	971	c.885C>T	c.(883-885)ctC>ctT	p.L295L		NM_005232.4	NP_005223.4	P21709	EPHA1_HUMAN	EPH receptor A1	295	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(21)|ovary(4)|skin(1)|stomach(1)|urinary_tract(3)	51	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GGGGGCACGTGAGACAATGGG	0.602000													11	52					0	0	1	0	0
WNT8A	7478	broad.mit.edu	37	5	137426590	137426590	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:137426590C>A	ENST00000506684.1	+	5	1174	c.938C>A	c.(937-939)aCt>aAt	p.T313N	WNT8A_ENST00000398754.1_Missense_Mutation_p.T295N			Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family, member 8A	295					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(2)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CGCCTGTGCACTGAGTGTGGG	0.552000													17	65					2.48551e-13	3.01753e-13	1	1	0
AGPAT4	56895	broad.mit.edu	37	6	161574502	161574502	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:161574502G>A	ENST00000320285.4	-	5	752	c.540C>T	c.(538-540)ttC>ttT	p.F180F	AGPAT4_ENST00000366911.5_3'UTR|AGPAT4_ENST00000457520.2_Intron|AGPAT4_ENST00000366908.5_3'UTR	NM_020133.2	NP_064518.1	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	180					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding			endometrium(1)|large_intestine(10)|lung(10)|ovary(2)|skin(2)	25		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		TCTTCTCCGTGAACCGTGTGC	0.617000													3	14					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54760128	54760128	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:54760128C>T	ENST00000450632.1	-	4	483	c.406G>A	c.(406-408)Gat>Aat	p.D136N	LILRB5_ENST00000449561.2_Missense_Mutation_p.D145N|LILRB5_ENST00000316219.5_Missense_Mutation_p.D145N|LILRB5_ENST00000345866.6_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	145	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCCAGTGTATCACACTGGAGG	0.547000													29	62					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39448619	39448619	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:39448619G>A	ENST00000257408.4	+	4	2370	c.2273G>A	c.(2272-2274)tGg>tAg	p.W758*		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	758	Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						GACTCGCACTGGAGGGCGGCC	0.677000													17	59					0	0	1	0	0
ANO9	338440	broad.mit.edu	37	11	431871	431871	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:431871C>G	ENST00000332826.6	-	6	526	c.442G>C	c.(442-444)Gag>Cag	p.E148Q		NM_001012302.2	NP_001012302.2	A1A5B4	ANO9_HUMAN	anoctamin 9	148						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						AACCTGGCCTCAAAGACCCCG	0.667000													5	32					0	0	1	0	0
SART1	9092	broad.mit.edu	37	11	65746353	65746353	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:65746353C>T	ENST00000312397.5	+	19	2444	c.2352C>T	c.(2350-2352)atC>atT	p.I784I		NM_005146.4	NP_005137.1	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T cells	784					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						CCCCCTACATCGTGCTCAGCG	0.667000													10	116					0	0	1	0	0
ZNF605	100289635	broad.mit.edu	37	12	133502297	133502297	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:133502297C>A	ENST00000360187.4	-	5	1936	c.1588G>T	c.(1588-1590)Gag>Tag	p.E530*	ZNF605_ENST00000392321.3_Nonsense_Mutation_p.E561*	NM_183238.3	NP_899061.1	Q86T29	ZN605_HUMAN	zinc finger protein 605	530					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(16)|large_intestine(5)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00227)|all_epithelial(31;0.142)		OV - Ovarian serous cystadenocarcinoma(86;9.24e-09)|Epithelial(86;2.11e-07)|all cancers(50;5.27e-06)		TAGGGTTTCTCCCCTGTATGA	0.428000													22	99					1.28384e-07	1.43227e-07	1	1	0
P2RX7	5027	broad.mit.edu	37	12	121613190	121613190	+	Splice_Site	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:121613190G>C	ENST00000328963.5	+	8	825		c.e8-1		P2RX7_ENST00000443520.3_Splice_Site|P2RX7_ENST00000535250.1_Splice_Site|P2RX7_ENST00000377162.2_Splice_Site|P2RX7_ENST00000546057.1_Splice_Site|P2RX7_ENST00000541446.1_Splice_Site			A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7							integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TCTTCCTACAGATACGCCAAG	0.408000													10	72					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8235408	8235408	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:8235408C>A	ENST00000520004.1	-	3	775	c.511G>T	c.(511-513)Ggc>Tgc	p.G171C	SGK223_ENST00000330777.4_Missense_Mutation_p.G171C			Q86YV5	SG223_HUMAN		171							ATP binding|non-membrane spanning protein tyrosine kinase activity										TTCCTCTCGCCGCGGGGCTCA	0.592000													28	78					3.73148e-12	4.47175e-12	1	1	0
GRIN1	2902	broad.mit.edu	37	9	140059721	140059721	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:140059721C>T	ENST00000371561.3	+	19	3770	c.2673C>T	c.(2671-2673)ttC>ttT	p.F891F	GRIN1_ENST00000371550.4_Intron|GRIN1_ENST00000371546.4_Silent_p.F912F|GRIN1_ENST00000350902.5_3'UTR|GRIN1_ENST00000371553.3_Silent_p.F912F|GRIN1_ENST00000371555.4_Intron|GRIN1_ENST00000315048.3_Silent_p.F891F|GRIN1_ENST00000371559.4_Intron|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000371560.3_Intron	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	891					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CTTCCAGCTTCAAGAGGCGTA	0.552000													18	89					0	0	1	0	0
ZBED4	9889	broad.mit.edu	37	22	50279146	50279146	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:50279146G>A	ENST00000216268.4	+	2	2313	c.1836G>A	c.(1834-1836)ctG>ctA	p.L612L		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	612						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		GCAACGTGCTGAAAACTGAGG	0.582000													20	50					0	0	1	0	0
CBWD1	55871	broad.mit.edu	37	9	154768	154768	+	Silent	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:154768G>C	ENST00000377447.3	-	8	658	c.603C>G	c.(601-603)ctC>ctG	p.L201L	CBWD1_ENST00000314367.10_Silent_p.L165L|CBWD1_ENST00000356521.4_Silent_p.L201L|CBWD1_ENST00000382447.4_Silent_p.L201L|CBWD1_ENST00000377400.4_Intron			Q9BRT8	CBWD1_HUMAN	COBW domain containing 1	201							ATP binding|protein binding			kidney(1)|lung(2)|ovary(1)|skin(1)	5	all_lung(41;0.218)	all_cancers(5;3.04e-16)|all_epithelial(5;4.68e-12)|all_lung(10;1.94e-10)|Lung NSC(10;3.61e-10)|Acute lymphoblastic leukemia(5;0.00439)|Breast(48;0.0148)|all_hematologic(5;0.024)|Prostate(43;0.122)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		TTTTATTAATGAGAATGGCAT	0.328000													14	96					0	0	1	0	0
PPEF2	5470	broad.mit.edu	37	4	76793183	76793183	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:76793183C>A	ENST00000286719.7	-	13	2000	c.1644G>T	c.(1642-1644)agG>agT	p.R548S		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	548					detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CTTGCCTTTGCCTCATGGTGA	0.403000													18	73					3.51602e-12	4.22036e-12	1	1	0
CUL3	8452	broad.mit.edu	37	2	225422486	225422486	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:225422486G>C	ENST00000264414.4	-	2	492	c.154C>G	c.(154-156)Ctt>Gtt	p.L52V	CUL3_ENST00000344951.4_Intron|CUL3_ENST00000409777.1_Missense_Mutation_p.L28V|CUL3_ENST00000432260.2_5'UTR|CUL3_ENST00000409096.1_Missense_Mutation_p.L28V	NM_003590.4	NP_003581.1	Q13618	CUL3_HUMAN	cullin 3	52					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TCAAAACTAAGACCACTGTTA	0.358000													9	51					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30747668	30747668	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:30747668G>T	ENST00000262518.4	+	32	7262	c.6877G>T	c.(6877-6879)Gag>Tag	p.E2293*	SRCAP_ENST00000344771.4_Nonsense_Mutation_p.E2135*|SRCAP_ENST00000395059.2_Nonsense_Mutation_p.E2231*	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2293	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			GGCTGAGGATGAGGAGATGTC	0.567000													19	55					2.4624e-09	2.86765e-09	1	1	0
KRT6B	3854	broad.mit.edu	37	12	52841737	52841737	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:52841737C>A	ENST00000252252.3	-	7	1296	c.1249G>T	c.(1249-1251)Gag>Tag	p.E417*		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	417	Coil 2.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		AGGGCCATCTCCCCACGCTGC	0.562000													7	136					0.0381472	0.0385624	1	1	0
RBM25	58517	broad.mit.edu	37	14	73569914	73569914	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr14:73569914G>T	ENST00000261973.7	+	10	1167	c.882G>T	c.(880-882)gaG>gaT	p.E294D	RBM25_ENST00000527432.1_Missense_Mutation_p.E294D	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	294	Glu-rich.|Necessary for nuclear speckle localization.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		TGgaagaagagaaaggcaaaa	0.443000													6	26					3.59834e-05	3.83582e-05	1	1	0
GRK6	2870	broad.mit.edu	37	5	176867754	176867754	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:176867754C>T	ENST00000355472.5	+	14	1626	c.1458C>T	c.(1456-1458)gtC>gtT	p.V486V	GRK6_ENST00000528793.1_Silent_p.V486V|GRK6_ENST00000355958.5_Silent_p.V486V|PRR7-AS1_ENST00000425316.3_RNA|GRK6_ENST00000393576.3_Silent_p.V452V	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	486	AGC-kinase C-terminal.				regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity	p.V486V(1)		breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTCTACGGTCAAGGGCGTGG	0.582000													5	56					0	0	1	0	0
RETNLB	84666	broad.mit.edu	37	3	108476012	108476012	+	Silent	SNP	G	G	T	rs141416455	by1000genomes	TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:108476012G>T	ENST00000295755.6	-	1	219	c.21C>A	c.(19-21)ctC>ctA	p.L7L		NM_032579.2	NP_115968.1	Q9BQ08	RETNB_HUMAN	resistin like beta	7					cell proliferation	extracellular region	hormone activity			endometrium(1)|kidney(3)|lung(10)|prostate(1)|skin(1)	16						GGATGAGAAGGAGGCAAGAGG	0.517000													14	36					1.5739e-10	1.8562e-10	1	1	0
MARC2	54996	broad.mit.edu	37	1	220928439	220928439	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:220928439C>G	ENST00000366913.3	+	2	621	c.423C>G	c.(421-423)tcC>tcG	p.S141S	MARC2_ENST00000359316.2_Silent_p.S141S	NM_017898.3	NP_060368.2	Q969Z3	MOSC2_HUMAN	mitochondrial amidoxime reducing component 2	141						mitochondrial outer membrane|peroxisome	molybdenum ion binding|oxidoreductase activity|pyridoxal phosphate binding										AGCAGCCTTCCTCAAACAAAC	0.522000													32	178					0	0	1	0	0
RNF133	168433	broad.mit.edu	37	7	122338834	122338834	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:122338834G>A	ENST00000340112.2	-	1	376	c.139C>T	c.(139-141)Cat>Tat	p.H47Y	CADPS2_ENST00000412584.2_Intron|CADPS2_ENST00000449022.2_Intron|CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000313070.7_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	47						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						TTCCCAACATGAAATGATATG	0.448000													32	132					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179532244	179532244	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:179532244G>T	ENST00000589042.1	-	161	35862	c.35638C>A	c.(35638-35640)Cca>Aca	p.P11880T	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10019	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.P182T(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTTGGGTGGCTCAGGCACT	0.308000													6	28					5.18039e-06	5.59452e-06	1	1	0
PKNOX1	5316	broad.mit.edu	37	21	44441416	44441416	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr21:44441416C>T	ENST00000291547.5	+	8	935	c.724C>T	c.(724-726)Cag>Tag	p.Q242*	PKNOX1_ENST00000432907.2_Nonsense_Mutation_p.Q125*	NM_004571.3	NP_004562.2	P55347	PKNX1_HUMAN	PBX/knotted 1 homeobox 1	242							sequence-specific DNA binding			cervix(3)|endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(8)|ovary(1)|prostate(1)	22						TTAAAAGCTTCAGTTACAGTT	0.418000													3	32					0	0	1	0	0
KCNB1	3745	broad.mit.edu	37	20	48098843	48098843	+	Nonsense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:48098843T>A	ENST00000371741.4	-	1	341	c.175A>T	c.(175-177)Aag>Tag	p.K59*		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	59					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TCGCGGAGCTTGCCCAGCCGC	0.682000													8	25					0	0	1	0	0
ATP11B	23200	broad.mit.edu	37	3	182597428	182597428	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:182597428G>A	ENST00000323116.5	+	20	2657	c.2397G>A	c.(2395-2397)caG>caA	p.Q799Q		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	799					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.Q799H(1)		breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			CTCCACTGCAGAAAGCAAAAG	0.343000													5	67					0	0	1	0	0
SP100	6672	broad.mit.edu	37	2	231328805	231328805	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:231328805G>A	ENST00000264052.5	+	11	1436	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K	SP100_ENST00000341950.4_Missense_Mutation_p.E361K|SP100_ENST00000427101.2_Missense_Mutation_p.E336K|SP100_ENST00000409897.1_Missense_Mutation_p.E326K|SP100_ENST00000409112.1_Missense_Mutation_p.E361K|SP100_ENST00000340126.4_Missense_Mutation_p.E361K|SP100_ENST00000409341.1_Missense_Mutation_p.E361K|SP100_ENST00000409824.1_Missense_Mutation_p.E336K	NM_003113.3	NP_003104.2	P23497	SP100_HUMAN	SP100 nuclear antigen	361					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CAACCCTTTAGAATCAAATGA	0.413000													16	33					0	0	1	0	0
FCGR3B	2215	broad.mit.edu	37	1	161596006	161596006	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:161596006G>C	ENST00000294800.3	-	4	779	c.506C>G	c.(505-507)tCc>tGc	p.S169C	FCGR2B_ENST00000428605.2_Intron|FCGR2B_ENST00000403078.3_Intron|FCGR2B_ENST00000367960.5_Intron|FCGR2B_ENST00000367962.4_Intron|FCGR3A_ENST00000540048.1_Intron|FCGR3B_ENST00000367964.2_Missense_Mutation_p.S169C|FCGR3B_ENST00000531221.1_Missense_Mutation_p.S205C	NM_001244753.1|NM_001271035.1	NP_001231682.1|NP_001257964.1	O75015	FCG3B_HUMAN	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	169	Ig-like C2-type 2.				immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	18	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GCAGAAGTAGGAGCCGCTATC	0.448000													20	122					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55221638	55221638	+	RNA	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:55221638G>A	ENST00000413439.1	+	0	1415																											GATCGCAGGTGAGGAGCCCAG	0.677000													6	34					0	0	1	0	0
CALR	811	broad.mit.edu	37	19	13051205	13051205	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:13051205C>T	ENST00000316448.5	+	5	714	c.641C>T	c.(640-642)tCa>tTa	p.S214L		NM_004343.3	NP_004334.1	P27797	CALR_HUMAN	calreticulin	214	4 X approximate repeats.|P-domain.				cell cycle arrest|cellular senescence|glucocorticoid receptor signaling pathway|negative regulation of neuron differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of steroid hormone receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of translation|peptide antigen assembly with MHC class I protein complex|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of phagocytosis|post-translational protein modification|protein export from nucleus|protein maturation by protein folding|protein N-linked glycosylation via asparagine|protein stabilization|regulation of apoptosis|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|extracellular space|MHC class I peptide loading complex|nucleus|perinuclear region of cytoplasm|polysome|proteinaceous extracellular matrix	androgen receptor binding|calcium ion binding|chaperone binding|complement component C1q binding|DNA binding|integrin binding|mRNA binding|protein binding involved in protein folding|sugar binding|ubiquitin protein ligase binding|unfolded protein binding|zinc ion binding			kidney(1)|large_intestine(3)|lung(5)|ovary(1)	10					Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTGATGCTTCAAAACCGGAA	0.542000													17	54					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8825233	8825233	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr18:8825233C>T	ENST00000359865.3	+	15	3867	c.3725C>T	c.(3724-3726)tCc>tTc	p.S1242F	SOGA2_ENST00000518815.1_Missense_Mutation_p.S567F|SOGA2_ENST00000400050.3_Missense_Mutation_p.S1201F|SOGA2_ENST00000517570.1_Missense_Mutation_p.S1201F|SOGA2_ENST00000306285.7_Missense_Mutation_p.S567F|SOGA2_ENST00000306329.11_Missense_Mutation_p.S1561F	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1552																	CCTTGCACCTCCCCCAGGCAC	0.667000													6	38					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31091305	31091305	+	Missense_Mutation	SNP	C	C	T	rs79856312	byFrequency	TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:31091305C>T	ENST00000332585.6	+	1	513	c.409C>T	c.(409-411)Ctc>Ttc	p.L137F	OSBP2_ENST00000403222.3_Intron|OSBP2_ENST00000407373.1_Intron|OSBP2_ENST00000382310.3_Missense_Mutation_p.L137F|OSBP2_ENST00000446658.2_Missense_Mutation_p.L137F	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	137					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						CGCGACCTTTCTCAGACCCGA	0.657000													4	60					0	0	1	0	0
GXYLT2	727936	broad.mit.edu	37	3	73004335	73004335	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:73004335G>A	ENST00000389617.4	+	4	848	c.687G>A	c.(685-687)ctG>ctA	p.L229L		NM_001080393.1	NP_001073862.1	A0PJZ3	GXLT2_HUMAN	glucoside xylosyltransferase 2	229					O-glycan processing	integral to membrane	UDP-xylosyltransferase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	18						GGAAGCTTCTGAGGCTGTTTA	0.498000													4	37					0	0	1	0	0
RP11-344E13.3	0	broad.mit.edu	37	17	20805922	20805922	+	RNA	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:20805922C>T	ENST00000577537.1	+	0	1106				RP11-344E13.3_ENST00000577860.1_RNA|RP11-344E13.3_ENST00000417232.2_RNA|RP11-344E13.3_ENST00000583962.1_RNA|RP11-344E13.3_ENST00000439794.2_RNA																							CTGTGCTTTGCACTCATTCCC	0.582000													6	28					0	0	1	0	0
LCA5	167691	broad.mit.edu	37	6	80223453	80223453	+	Missense_Mutation	SNP	G	G	A	rs145854631	byFrequency	TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:80223453G>A	ENST00000392959.1	-	4	807	c.196C>T	c.(196-198)Cgg>Tgg	p.R66W	LCA5_ENST00000467898.2_Missense_Mutation_p.R66W|LCA5_ENST00000369846.4_Missense_Mutation_p.R66W	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	66			R -> Q (in dbSNP:rs35338066).		protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		CTTGGTTTCCGAGGGGCTAAA	0.443000													39	127					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48210974	48210974	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:48210974C>A	ENST00000394747.1	-	24	3748	c.3399G>T	c.(3397-3399)caG>caT	p.Q1133H	ABCC11_ENST00000394748.1_Missense_Mutation_p.Q1133H|ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000353782.5_Missense_Mutation_p.Q1133H|ABCC11_ENST00000356608.2_Missense_Mutation_p.Q1133H	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1133						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.Q1133H(1)		breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GTGGCCACCCCTGGGGACAAC	0.458000													10	54					3.07112e-06	3.33115e-06	1	1	0
TCTA	6988	broad.mit.edu	37	3	49450518	49450518	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:49450518G>T	ENST00000273590.3	+	2	465	c.244G>T	c.(244-246)Gat>Tat	p.D82Y	TCTA_ENST00000493381.1_3'UTR	NM_022171.2	NP_071503.1	P57738	TCTA_HUMAN	T-cell leukemia translocation altered	82						integral to membrane				large_intestine(4)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		ATCCACGCCTGATGGCTCCAC	0.572000													13	40					0.000151284	0.000160349	1	1	0
MTA1	9112	broad.mit.edu	37	14	105931079	105931079	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr14:105931079C>T	ENST00000331320.7	+	15	1627	c.1413C>T	c.(1411-1413)ttC>ttT	p.F471F	MTA1_ENST00000406191.1_Silent_p.F471F|MTA1_ENST00000405646.1_Silent_p.F454F|MTA1_ENST00000435036.2_Silent_p.F7F	NM_001203258.1|NM_004689.3	NP_001190187.1|NP_004680.2	Q13330	MTA1_HUMAN	metastasis associated 1	471					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|stomach(1)	14		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		GGCAGGCTTTCTATCTGCACA	0.682000													7	28					0	0	1	0	0
STYXL1	51657	broad.mit.edu	37	7	75625801	75625801	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:75625801C>T	ENST00000248600.1	-	9	1269	c.927G>A	c.(925-927)atG>atA	p.M309I	STYXL1_ENST00000359697.3_Missense_Mutation_p.M309I|STYXL1_ENST00000431581.1_Missense_Mutation_p.M309I|STYXL1_ENST00000360591.3_3'UTR|STYXL1_ENST00000340062.5_Missense_Mutation_p.M213I	NM_016086.2	NP_057170.1	Q9Y6J8	STYL1_HUMAN	serine/threonine/tyrosine interacting-like 1	309					intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	10						AGAGCGGATCCATGATGTTTG	0.522000													18	46					0	0	1	0	0
MIR521-1	574494	broad.mit.edu	37	19	54251946	54251946	+	RNA	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:54251946G>C	ENST00000384902.1	+	0	57					NR_030216.1																						AGAAAAGAACGCACTTCCCTT	0.433000													18	83					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14903476	14903476	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chrY:14903476G>A	ENST00000338981.3	+	26	4677	c.3732G>A	c.(3730-3732)caG>caA	p.Q1244Q	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	1244					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GGGCTATACAGAAAATTATCT	0.318000													6	10					0	0	1	0	0
ACSM2B	348158	broad.mit.edu	37	16	20563501	20563501	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:20563501G>C	ENST00000329697.6	-	6	1027	c.859C>G	c.(859-861)Ctc>Gtc	p.L287V	ACSM2B_ENST00000567001.1_Missense_Mutation_p.L287V|ACSM2B_ENST00000567288.1_5'UTR|ACSM2B_ENST00000565232.1_Missense_Mutation_p.L287V|ACSM2B_ENST00000565322.1_Missense_Mutation_p.L208V	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	287					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TTTGGCAAGAGATGAACAAAT	0.423000													33	175					0	0	1	0	0
LCE2A	353139	broad.mit.edu	37	1	152671606	152671606	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:152671606T>G	ENST00000368779.1	+	2	280	c.229T>G	c.(229-231)Ttc>Gtc	p.F77V		NM_178428.3	NP_848515.1	Q5TA79	LCE2A_HUMAN	late cornified envelope 2A	77	Cys-rich.				keratinization					breast(1)|large_intestine(1)|liver(2)|lung(4)	8	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCCCGTCTCTTCCACCGGCA	0.682000													14	151					0	0	1	0	0
FAM111B	374393	broad.mit.edu	37	11	58892342	58892342	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:58892342G>A	ENST00000343597.3	+	4	963	c.772G>A	c.(772-774)Gaa>Aaa	p.E258K	FAM111B_ENST00000529618.1_Missense_Mutation_p.E228K|FAM111B_ENST00000411426.1_Missense_Mutation_p.E228K	NM_198947.3	NP_945185.1	Q6SJ93	F111B_HUMAN	family with sequence similarity 111, member B	258							catalytic activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(12)|ovary(3)|pancreas(1)|skin(1)	40						CATGGTGGATGAAGTATCTGG	0.338000													8	77					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215813914	215813914	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:215813914C>G	ENST00000366943.2	-	68	15340	c.14954G>C	c.(14953-14955)aGa>aCa	p.R4985T	USH2A_ENST00000307340.3_Missense_Mutation_p.R4985T			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4985	Fibronectin type-III 35.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTCCGCCGTTCTCGGTATGTA	0.542000										HNSCC(13;0.011)			8	68					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110385163	110385163	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:110385163C>T	ENST00000360185.4	-	14	1553	c.1389G>A	c.(1387-1389)atG>atA	p.M463I	GIT2_ENST00000553118.1_Intron|GIT2_ENST00000355312.3_Missense_Mutation_p.M513I|TCHP_ENST00000550780.1_Intron|GIT2_ENST00000547815.1_3'UTR|GIT2_ENST00000457474.2_Missense_Mutation_p.M465I|GIT2_ENST00000338373.5_Intron|GIT2_ENST00000343646.5_Missense_Mutation_p.M433I|GIT2_ENST00000354574.4_Missense_Mutation_p.M465I|GIT2_ENST00000356259.4_Intron|GIT2_ENST00000361006.5_Missense_Mutation_p.M513I|GIT2_ENST00000551209.1_Missense_Mutation_p.M462I			Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	513					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						CGTACATGGACATGGGCCTAC	0.557000													15	60					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92086269	92086269	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:92086269C>A	ENST00000298047.6	+	1	1008	c.991C>A	c.(991-993)Cag>Aag	p.Q331K	FAT3_ENST00000409404.2_Missense_Mutation_p.Q331K|FAT3_ENST00000525166.1_Missense_Mutation_p.Q181K|FAT3_ENST00000541502.1_Missense_Mutation_p.Q331K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	331	Cadherin 3.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GGAGAGGAAGCAGATTGACTG	0.433000										TCGA Ovarian(4;0.039)			5	45					0.014758	0.0149798	1	1	0
OVCH1	341350	broad.mit.edu	37	12	29631788	29631788	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:29631788G>T	ENST00000318184.5	-	9	1048	c.1049C>A	c.(1048-1050)tCa>tAa	p.S350*	OVCH1-AS1_ENST00000549411.1_Intron|OVCH1-AS1_ENST00000551108.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	350	CUB 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity	p.S350*(1)		NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TCCACTGCTTGATCGTAAAGA	0.294000													4	18					1	1	1	1	0
GNAQ	2776	broad.mit.edu	37	9	80409473	80409473	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:80409473C>T	ENST00000286548.4	-	5	863	c.641G>A	c.(640-642)aGa>aAa	p.R214K	GNAQ_ENST00000397476.3_Missense_Mutation_p.R12K	NM_002072.3	NP_002063.2	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein), q polypeptide	214					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			NS(1)|endometrium(3)|eye(229)|kidney(1)|large_intestine(4)|lung(6)|meninges(11)|ovary(1)|prostate(1)|skin(44)|upper_aerodigestive_tract(1)	302						TATCCATTTTCTTCTCTCTGA	0.353000			Mis		uveal melanoma								7	82					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169208281	169208281	+	Silent	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:169208281G>C	ENST00000393743.3	-	10	1548	c.1257C>G	c.(1255-1257)gtC>gtG	p.V419V		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	419							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CAAAGTCTCTGACCAACTTTG	0.318000													11	65					0	0	1	0	0
SFRP1	6422	broad.mit.edu	37	8	41164258	41164258	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:41164258G>C	ENST00000379845.3	-	1	251	c.119C>G	c.(118-120)tCc>tGc	p.S40C	SFRP1_ENST00000220772.3_Intron			Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	0					brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			CTGCTGGGAGGAGTGGAGGTG	0.607000													4	9					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	187005192	187005192	+	Silent	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:187005192C>G	ENST00000296795.2	+	4	2456	c.2352C>G	c.(2350-2352)ctC>ctG	p.L784L	TLR3_ENST00000504367.1_Silent_p.L507L	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	784	TIR.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		ACCAATCTCTCAAATTTTGTC	0.343000													18	99					0	0	1	0	0
NOTUM	147111	broad.mit.edu	37	17	79914845	79914845	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:79914845C>A	ENST00000409678.3	-	7	1184	c.801G>T	c.(799-801)tgG>tgT	p.W267C		NM_178493.5	NP_848588.3	Q6P988	NOTUM_HUMAN	notum pectinacetylesterase homolog (Drosophila)	267						extracellular region	hydrolase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	15	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			TGTCCAGGAACCAGCCGGAGT	0.672000													5	22					1.23904e-05	1.33036e-05	1	1	0
ADCK3	56997	broad.mit.edu	37	1	227174301	227174301	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:227174301C>G	ENST00000366779.1	+	20	4578	c.1807C>G	c.(1807-1809)Ccc>Gcc	p.P603A	ADCK3_ENST00000366778.1_Missense_Mutation_p.P551A|ADCK3_ENST00000366777.3_Missense_Mutation_p.P603A|ADCK3_ENST00000433743.2_Missense_Mutation_p.P277A|ADCK3_ENST00000366776.1_Missense_Mutation_p.P528A|ADCK3_ENST00000366775.1_Missense_Mutation_p.P448A|ADCK3_ENST00000458507.2_Missense_Mutation_p.P324A|ADCK3_ENST00000478406.1_3'UTR			Q8NI60	ADCK3_HUMAN	aarF domain containing kinase 3	603					cell death	mitochondrion	ATP binding|protein serine/threonine kinase activity			endometrium(1)|kidney(2)|large_intestine(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	9						CGTCCCCCCACCCGAGGAAAC	0.592000													11	151					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10942755	10942755	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr21:10942755C>T	ENST00000298232.7	-	12	999	c.632G>A	c.(631-633)cGa>cAa	p.R211Q	TPTE_ENST00000342420.5_Missense_Mutation_p.R191Q|TPTE_ENST00000361285.4_Missense_Mutation_p.R229Q|TPTE_ENST00000415664.2_5'UTR	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	229					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCTTGTGTATCGCCTTTTGTT	0.323000													50	464					0	0	1	0	0
TECPR2	9895	broad.mit.edu	37	14	102898216	102898216	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr14:102898216G>A	ENST00000359520.7	+	8	1394	c.1168G>A	c.(1168-1170)Gag>Aag	p.E390K	TECPR2_ENST00000558678.1_Missense_Mutation_p.E390K	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	390							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						CACAGTTTCTGAGACGAGGCT	0.607000													16	71					0	0	1	0	0
LMAN1L	79748	broad.mit.edu	37	15	75108852	75108852	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:75108852G>T	ENST00000309664.5	+	3	554	c.415G>T	c.(415-417)Gac>Tac	p.D139Y	LMAN1L_ENST00000379709.3_Missense_Mutation_p.D139Y	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	139	L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GATCTTCTTTGACTCTCCGGC	0.687000													26	87					7.76418e-22	9.87806e-22	1	1	0
CARS2	79587	broad.mit.edu	37	13	111340150	111340150	+	Silent	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr13:111340150C>A	ENST00000257347.4	-	5	552	c.489G>T	c.(487-489)ctG>ctT	p.L163L	CARS2_ENST00000535398.1_5'UTR	NM_024537.2	NP_078813.1	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial (putative)	163					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|prostate(4)|skin(1)	13	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	CGGTTACCCTCAGGTACACCG	0.483000													11	197					0.000673444	0.00070178	1	1	0
FREM2	341640	broad.mit.edu	37	13	39264368	39264368	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr13:39264368G>A	ENST00000280481.7	+	1	3103	c.2887G>A	c.(2887-2889)Gaa>Aaa	p.E963K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	963					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGGGGCTACTGAAATCACTGC	0.453000													5	88					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90144596	90144596	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:90144596G>A	ENST00000268138.7	+	10	2326	c.2221G>A	c.(2221-2223)Gat>Aat	p.D741N	TICRR_ENST00000560985.1_Missense_Mutation_p.D740N					TOPBP1-interacting checkpoint and replication regulator																		TGAAAGTACAGATGATATGGA	0.413000													19	79					0	0	1	0	0
SGCD	6444	broad.mit.edu	37	5	156022008	156022008	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:156022008T>C	ENST00000435422.3	+	5	933	c.446T>C	c.(445-447)tTc>tCc	p.F149S	SGCD_ENST00000337851.4_Missense_Mutation_p.F150S|SGCD_ENST00000447401.1_Missense_Mutation_p.F150S|SGCD_ENST00000517913.1_Missense_Mutation_p.F150S	NM_001128209.1	NP_001121681.1	Q92629	SGCD_HUMAN	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	149					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|prostate(1)	24	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AAATTGCTCTTCTCTGCAGAC	0.363000													6	25					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36006412	36006412	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr13:36006412G>C	ENST00000540320.1	+	39	6720	c.6186G>C	c.(6184-6186)ttG>ttC	p.L2062F	NBEA_ENST00000310336.4_Missense_Mutation_p.L2062F|NBEA_ENST00000379939.2_Missense_Mutation_p.L2059F|NBEA_ENST00000400445.3_Missense_Mutation_p.L2062F			Q8NFP9	NBEA_HUMAN	neurobeachin	2062						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TTAGCCAATTGCATGATTTCT	0.378000													4	16					0	0	1	0	0
FBXW7	55294	broad.mit.edu	37	4	153258956	153258956	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:153258956C>T	ENST00000281708.4	-	5	2088	c.859G>A	c.(859-861)Gag>Aag	p.E287K	FBXW7_ENST00000393956.3_Missense_Mutation_p.E111K|FBXW7_ENST00000603841.1_Missense_Mutation_p.E287K|RP11-461L13.2_ENST00000605147.1_RNA|FBXW7_ENST00000263981.5_Missense_Mutation_p.E207K|FBXW7_ENST00000296555.5_Missense_Mutation_p.E169K|FBXW7_ENST00000603548.1_Missense_Mutation_p.E287K	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	287	F-box.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ATCTTTACCTCTTTAGGGAGC	0.343000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								17	78					0	0	1	0	0
PTTG1	9232	broad.mit.edu	37	5	159854878	159854878	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:159854878C>G	ENST00000393964.1	+	4	930	c.527C>G	c.(526-528)tCc>tGc	p.S176C	PTTG1_ENST00000519287.1_3'UTR|PTTG1_ENST00000520452.1_Missense_Mutation_p.S176C|PTTG1_ENST00000352433.5_Missense_Mutation_p.S176C			O95997	PTTG1_HUMAN	pituitary tumor-transforming 1	176					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|chromosome organization|chromosome segregation|DNA repair|mitosis|spermatogenesis|transcription from RNA polymerase II promoter	cytosol|nucleus	cysteine-type endopeptidase inhibitor activity|sequence-specific DNA binding transcription factor activity|SH3 domain binding			breast(1)|large_intestine(1)|lung(4)	6	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.00219)|Epithelial(171;0.00348)|all cancers(165;0.0104)		CCATGGGAATCCAGTAAGTGA	0.522000													12	54					0	0	1	0	0
SIK1	150094	broad.mit.edu	37	21	44836666	44836666	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr21:44836666C>T	ENST00000270162.6	-	14	2440	c.2308G>A	c.(2308-2310)Gac>Aac	p.D770N		NM_173354.3	NP_775490.2	P57059	SIK1_HUMAN	salt-inducible kinase 1	770					anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|testis(2)|urinary_tract(1)	21						GGCATCAGGTCCTCCATCTCA	0.662000													10	33					0	0	1	0	0
RNF167	26001	broad.mit.edu	37	17	4848207	4848207	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:4848207C>G	ENST00000262482.6	+	10	1605	c.949C>G	c.(949-951)Ctt>Gtt	p.L317V	RNF167_ENST00000572430.1_Missense_Mutation_p.L317V|RNF167_ENST00000575111.1_Missense_Mutation_p.L317V|RNF167_ENST00000571816.1_Missense_Mutation_p.L317V|RNF167_ENST00000576229.1_Missense_Mutation_p.L282V	NM_015528.1	NP_056343.1	Q9H6Y7	RN167_HUMAN	ring finger protein 167	317					negative regulation of cell cycle|protein polyubiquitination	cytoplasm|endomembrane system|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(1)	4						TAGCCCCACTCTTCCCACCTC	0.572000													48	178					0	0	1	0	0
KIFC1	3833	broad.mit.edu	37	6	33373021	33373021	+	Silent	SNP	A	A	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:33373021A>G	ENST00000428849.2	+	7	1599	c.1149A>G	c.(1147-1149)ggA>ggG	p.G383G		NM_002263.3	NP_002254.2	Q9BW19	KIFC1_HUMAN	kinesin family member C1	383	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|mitotic sister chromatid segregation	early endosome|microtubule|microtubule associated complex|microtubule organizing center|nucleus|spindle	ATP binding|microtubule motor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	13						CAGGAAGTGGACAGGATGAAG	0.562000													60	127					0	0	1	0	0
NMT1	4836	broad.mit.edu	37	17	43182236	43182236	+	Missense_Mutation	SNP	G	G	C	rs1802201		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:43182236G>C	ENST00000592782.1	+	12	1473	c.1342G>C	c.(1342-1344)Gat>Cat	p.D448H	NMT1_ENST00000258960.2_Missense_Mutation_p.D448H			P30419	NMT1_HUMAN	N-myristoyltransferase 1	448					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	8		Prostate(33;0.155)				GAAAGGGTTTGATGTGTTCAA	0.493000													12	46					0	0	1	0	0
WSB1	26118	broad.mit.edu	37	17	25630601	25630601	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:25630601C>T	ENST00000262394.2	+	3	734	c.418C>T	c.(418-420)Cag>Tag	p.Q140*	WSB1_ENST00000427287.2_Nonsense_Mutation_p.Q109*|WSB1_ENST00000583193.1_Intron|WSB1_ENST00000348811.2_Intron|WSB1_ENST00000581185.1_Nonsense_Mutation_p.Q140*|WSB1_ENST00000579733.1_Intron	NM_015626.8	NP_056441.6	Q9Y6I7	WSB1_HUMAN	WD repeat and SOCS box containing 1	140					intracellular signal transduction	intracellular	protein binding			lung(3)	3	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		TGGACAAGATCAGCTACTTCT	0.368000													48	170					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37282732	37282732	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:37282732C>T	ENST00000373091.3	-	13	2036	c.2020G>A	c.(2020-2022)Gat>Aat	p.D674N	GRIK3_ENST00000373093.4_Missense_Mutation_p.D674N	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	674					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GCCAGGTCATCAGCAGAGTCA	0.547000													15	62					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70513316	70513316	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:70513316C>A	ENST00000503640.1	-	1	102	c.47G>T	c.(46-48)gGa>gTa	p.G16V	UGT2A1_ENST00000514019.1_Missense_Mutation_p.G16V|UGT2A1_ENST00000286604.4_Missense_Mutation_p.G16V|UGT2A1_ENST00000512704.1_Missense_Mutation_p.G16V	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	16					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						AAGAGTGGTTCCTATGAGACT	0.373000													9	30					5.4927e-09	6.36674e-09	1	1	0
EEF2K	29904	broad.mit.edu	37	16	22269092	22269092	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:22269092G>A	ENST00000263026.5	+	9	1503		c.e9+1			NM_013302.3	NP_037434.1	O00418	EF2K_HUMAN	eukaryotic elongation factor-2 kinase						insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(8)|large_intestine(2)|lung(13)|ovary(1)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(48;0.0223)		CAAGCTGCTGGTGGGTGCCCA	0.607000													32	97					0	0	1	0	0
PNPLA3	80339	broad.mit.edu	37	22	44333103	44333103	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:44333103G>T	ENST00000216180.3	+	6	1103	c.930G>T	c.(928-930)ctG>ctT	p.L310L	PNPLA3_ENST00000423180.2_Silent_p.L306L	NM_025225.2	NP_079501.2	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	310					triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|prostate(1)|skin(1)|stomach(2)	19		Ovarian(80;0.024)|all_neural(38;0.0416)				TCAGCATCCTGCCCTGGGATG	0.607000													9	29					1.76689e-08	2.0322e-08	1	1	0
HCN1	348980	broad.mit.edu	37	5	45262242	45262242	+	Silent	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:45262242G>C	ENST00000303230.4	-	8	2511	c.2454C>G	c.(2452-2454)ccC>ccG	p.P818P		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	818						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CCGCCGTCACGGGTTGAGGGA	0.677000													14	30					0	0	1	0	0
FLNA	2316	broad.mit.edu	37	X	153593022	153593022	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chrX:153593022C>A	ENST00000422373.1	-	13	2142	c.1894G>T	c.(1894-1896)Gat>Tat	p.D632Y	FLNA_ENST00000360319.4_Missense_Mutation_p.D632Y|FLNA_ENST00000369850.3_Missense_Mutation_p.D632Y|FLNA_ENST00000344736.4_Missense_Mutation_p.D632Y	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	632					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TAGCGCACATCACAGGAGCCG	0.612000													27	31					6.12954e-19	7.75851e-19	1	1	0
INTS3	65123	broad.mit.edu	37	1	153721200	153721200	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:153721200G>A	ENST00000318967.2	+	6	1121	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K	INTS3_ENST00000456435.1_5'UTR|RP11-216N14.8_ENST00000453778.1_RNA|INTS3_ENST00000435409.2_Missense_Mutation_p.E185K	NM_023015.3	NP_075391.3	Q68E01	INT3_HUMAN	integrator complex subunit 3	186					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTGGTTGGCAGAAAGTGTTCT	0.458000													122	441					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100204142	100204142	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:100204142G>T	ENST00000355295.4	+	6	1135	c.840G>T	c.(838-840)tgG>tgT	p.W280C	TDRD7_ENST00000422139.2_Missense_Mutation_p.W206C	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	280	Lotus/OST-HTH 2.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				TTGAACACTGGCCTCATATTT	0.358000													16	64					8.60227e-14	1.05123e-13	1	1	0
SLC30A9	10463	broad.mit.edu	37	4	42022529	42022529	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:42022529C>G	ENST00000264451.6	+	4	611	c.431C>G	c.(430-432)tCc>tGc	p.S144C		NM_006345.3	NP_006336.3	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter), member 9	144					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TGCCTCAAATCCAGGTAATTT	0.348000													24	93					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398262	25398262	+	Missense_Mutation	SNP	C	C	A	rs121913538		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:25398262C>A	ENST00000311936.3	-	2	248	c.57G>T	c.(55-57)ttG>ttT	p.L19F	KRAS_ENST00000556131.1_Missense_Mutation_p.L19F|KRAS_ENST00000256078.4_Missense_Mutation_p.L19F|KRAS_ENST00000557334.1_Missense_Mutation_p.L19F	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	19					activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.L19F(15)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCTGTATCGTCAAGGCACTCT	0.358000		119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			8	24					1.76689e-08	2.0322e-08	1	1	0
ZNF239	8187	broad.mit.edu	37	10	44052848	44052848	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:44052848C>A	ENST00000306006.6	-	2	1332	c.680G>T	c.(679-681)aGa>aTa	p.R227I	ZNF239_ENST00000374446.2_Missense_Mutation_p.R227I|ZNF239_ENST00000426961.1_Missense_Mutation_p.R227I|ZNF239_ENST00000535642.1_Missense_Mutation_p.R227I	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	227					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGTGTGGTCTCTCTGATGAAG	0.453000													28	105					5.61819e-17	7.03931e-17	1	1	0
HK1	3098	broad.mit.edu	37	10	71160864	71160864	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:71160864G>T	ENST00000448642.2	+	23	3221	c.2832G>T	c.(2830-2832)gtG>gtT	p.V944V	HK1_ENST00000359426.6_Silent_p.V909V|HK1_ENST00000298649.3_Silent_p.V908V|HK1_ENST00000404387.2_Silent_p.V913V|HK1_ENST00000360289.2_Silent_p.V897V			P19367	HXK1_HUMAN	hexokinase 1	909					glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						CCGTGGGCGTGCGGTTACGCA	0.622000													5	31					1.23904e-05	1.33036e-05	1	1	0
DCP1B	196513	broad.mit.edu	37	12	2074748	2074748	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:2074748G>C	ENST00000280665.6	-	5	577	c.498C>G	c.(496-498)atC>atG	p.I166M	DCP1B_ENST00000540622.1_Missense_Mutation_p.I40M|DCP1B_ENST00000397173.4_Missense_Mutation_p.I64M|DCP1B_ENST00000541700.1_Intron	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	166					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			CTTTGGCCTTGATGAGCATTC	0.443000													8	25					0	0	1	0	0
FAM76B	143684	broad.mit.edu	37	11	95516337	95516337	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:95516337G>A	ENST00000358780.5	-	5	767	c.455C>T	c.(454-456)tCa>tTa	p.S152L	FAM76B_ENST00000536839.1_Missense_Mutation_p.S152L	NM_144664.4	NP_653265.3	Q5HYJ3	FA76B_HUMAN	family with sequence similarity 76, member B	152	Poly-Ser.									breast(1)|kidney(1)|lung(1)	3		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				ATTTGAATGTGAAGATCCCAG	0.398000													9	29					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183600966	183600966	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:183600966C>A	ENST00000511685.1	+	8	1597	c.1474C>A	c.(1474-1476)Cat>Aat	p.H492N	TENM3_ENST00000406950.2_Missense_Mutation_p.H492N					teneurin transmembrane protein 3																		TGGAATCTGGCATCTGGCTTT	0.483000													7	33					5.18039e-06	5.59452e-06	1	1	0
VANGL2	57216	broad.mit.edu	37	1	160390289	160390289	+	Missense_Mutation	SNP	G	G	T	rs61744131		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:160390289G>T	ENST00000368061.2	+	5	1363	c.889G>T	c.(889-891)Gtc>Ttc	p.V297F	VANGL2_ENST00000483408.1_Intron	NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	297					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane		p.V297I(1)		biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GCCCAAGTCCGTCCTGGCCAA	0.587000													84	57					1.68508e-47	2.16986e-47	1	1	0
RBM12B	389677	broad.mit.edu	37	8	94746110	94746110	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:94746110G>A	ENST00000399300.2	-	3	2742	c.2529C>T	c.(2527-2529)ttC>ttT	p.F843F	RBM12B_ENST00000517700.1_Silent_p.F723F|RP11-10N23.4_ENST00000517998.1_RNA|RBM12B_ENST00000520961.1_Intron	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	843							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GGAGCTGCCTGAAGTCCTCAT	0.547000													10	91					0	0	1	0	0
CMTR1	23070	broad.mit.edu	37	6	37430668	37430668	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:37430668G>A	ENST00000373451.4	+	13	1553	c.1389G>A	c.(1387-1389)gtG>gtA	p.V463V		NM_015050.2	NP_055865.1	Q8N1G2	MTR1_HUMAN		463					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(6)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(2)	31						TCTTCGCAGTGAATATTAAAC	0.507000													25	107					0	0	1	0	0
TMEM177	80775	broad.mit.edu	37	2	120438503	120438503	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:120438503C>A	ENST00000424086.1	+	2	547	c.74C>A	c.(73-75)gCa>gAa	p.A25E	TMEM177_ENST00000496203.1_Intron|TMEM177_ENST00000409951.1_Missense_Mutation_p.A25E|TMEM177_ENST00000401466.1_Missense_Mutation_p.A25E|TMEM177_ENST00000272521.6_Missense_Mutation_p.A25E	NM_001105198.1	NP_001098668.1	Q53S58	TM177_HUMAN	transmembrane protein 177	25						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	13	Colorectal(110;0.196)					GGTTCCTGTGCAGGCCTGTTT	0.607000													8	71					5.4927e-09	6.36674e-09	1	1	0
ZNF800	168850	broad.mit.edu	37	7	127014756	127014756	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:127014756G>A	ENST00000393313.1	-	5	1225	c.634C>T	c.(634-636)Cag>Tag	p.Q212*	ZNF800_ENST00000393312.1_Nonsense_Mutation_p.Q212*|ZNF800_ENST00000265827.3_Nonsense_Mutation_p.Q212*			Q2TB10	ZN800_HUMAN	zinc finger protein 800	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						TGCGACTCCTGAGGTTGTTCA	0.423000													48	140					0	0	1	0	0
GABRA2	2555	broad.mit.edu	37	4	46334680	46334680	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:46334680G>A	ENST00000510861.1	-	4	380	c.207C>T	c.(205-207)ttC>ttT	p.F69F	GABRA2_ENST00000507069.1_Silent_p.F69F|GABRA2_ENST00000514090.1_Silent_p.F69F|GABRA2_ENST00000515082.1_Silent_p.F69F|GABRA2_ENST00000540012.1_Intron|GABRA2_ENST00000381620.4_Silent_p.F69F|GABRA2_ENST00000356504.1_Silent_p.F69F			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	69					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGATGTTAGTGAAGACTTCAG	0.373000													10	90					0	0	1	0	0
DDX50	79009	broad.mit.edu	37	10	70706284	70706284	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:70706284G>C	ENST00000373585.3	+	15	2219	c.2112G>C	c.(2110-2112)caG>caC	p.Q704H	DDX50_ENST00000466265.1_3'UTR	NM_024045.1	NP_076950.1	Q9BQ39	DDX50_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 50	704	Arg-rich.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	29						CAGGTAGACAGAGTCGACAAG	0.537000													12	85					0	0	1	0	0
NLRP12	91662	broad.mit.edu	37	19	54313536	54313536	+	Missense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:54313536T>A	ENST00000324134.6	-	3	1545	c.1377A>T	c.(1375-1377)agA>agT	p.R459S	NLRP12_ENST00000354278.3_Missense_Mutation_p.R459S|NLRP12_ENST00000351894.4_Missense_Mutation_p.R459S|NLRP12_ENST00000391775.3_Missense_Mutation_p.R459S|NLRP12_ENST00000535162.1_Missense_Mutation_p.R459S|NLRP12_ENST00000391772.1_Missense_Mutation_p.R459S|NLRP12_ENST00000345770.5_Missense_Mutation_p.R459S|NLRP12_ENST00000391773.1_Missense_Mutation_p.R459S	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	459	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AGCACAACCCTCTCTGGTTGG	0.612000													26	103					0	0	1	0	0
GLE1	2733	broad.mit.edu	37	9	131301915	131301915	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:131301915G>T	ENST00000309971.4	+	14	2008	c.1902G>T	c.(1900-1902)atG>atT	p.M634I	GLE1_ENST00000372770.4_Missense_Mutation_p.M634I|GLE1_ENST00000539582.1_Missense_Mutation_p.M380I|RP11-216B9.6_ENST00000434999.1_RNA	NM_001003722.1	NP_001003722.1	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator	634					poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	16						ATGCCCTCATGAAGCAATACC	0.453000													5	74					0.014758	0.0149798	1	1	0
SLC17A6	57084	broad.mit.edu	37	11	22399117	22399117	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:22399117A>T	ENST00000263160.3	+	12	2017	c.1580A>T	c.(1579-1581)gAa>gTa	p.E527V		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	527					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						CTCGATGAAGAAACAGGGGAC	0.423000													16	67					0	0	1	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26032173	26032173	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:26032173G>T	ENST00000244661.2	-	1	115	c.116C>A	c.(115-117)cCt>cAt	p.P39H		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	39					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						GTAACGGTGAGGCTTTTTCAC	0.647000													37	180					6.97489e-18	8.79854e-18	1	1	0
LAMC1	3915	broad.mit.edu	37	1	182993002	182993002	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:182993002A>T	ENST00000258341.4	+	1	408	c.151A>T	c.(151-153)Atg>Ttg	p.M51L		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	51	Laminin N-terminal.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCAGCGCTGCATGCCCGAGTT	0.721000													4	41					0	0	1	0	0
OR6N2	81442	broad.mit.edu	37	1	158746766	158746766	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:158746766C>T	ENST00000339258.1	-	1	659	c.660G>A	c.(658-660)agG>agA	p.R220R		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	220					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					CCCCAATGATCCTTGCATAAG	0.418000													16	81					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31324549	31324549	+	Silent	SNP	T	T	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr18:31324549T>C	ENST00000269197.5	+	12	4737	c.4737T>C	c.(4735-4737)ttT>ttC	p.F1579F		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1579					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						GTCATAACTTTGCTGAGCAGG	0.468000											OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	15					0	0	1	0	0
RAB25	57111	broad.mit.edu	37	1	156040024	156040024	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:156040024G>T	ENST00000361084.5	+	5	829	c.588G>T	c.(586-588)caG>caT	p.Q196H		NM_020387.2	NP_065120.2	P57735	RAB25_HUMAN	RAB25, member RAS oncogene family	196					positive regulation of cell proliferation|protein transport|pseudopodium organization|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|pseudopodium membrane	GTP binding|identical protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	Hepatocellular(266;0.158)|all_neural(408;0.195)					GCAGTGCCCAGGCTGGACAGG	0.612000													15	66					6.72482e-11	7.94363e-11	1	1	0
SLC39A12	221074	broad.mit.edu	37	10	18289726	18289726	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:18289726C>G	ENST00000377369.2	+	11	2004	c.1731C>G	c.(1729-1731)atC>atG	p.I577M	SLC39A12_ENST00000377374.4_Missense_Mutation_p.I540M|SLC39A12_ENST00000539911.1_Missense_Mutation_p.I443M|SLC39A12_ENST00000377371.3_Missense_Mutation_p.I576M	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	577					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						CGATTGCTATCTTGTGTCATG	0.438000													4	59					0	0	1	0	0
PNPLA7	375775	broad.mit.edu	37	9	140444638	140444638	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:140444638C>G	ENST00000406427.1	-	1	348	c.12G>C	c.(10-12)gaG>gaC	p.E4D	PNPLA7_ENST00000277531.4_Missense_Mutation_p.E4D	NM_001098537.1	NP_001092007.1	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	4					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		TGTCATCTTTCTCTTCCTCCA	0.547000													16	94					0	0	1	0	0
WEE1	7465	broad.mit.edu	37	11	9608065	9608065	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:9608065G>A	ENST00000299613.6	+	9	1653	c.898G>A	c.(898-900)Gaa>Aaa	p.E300K	WEE1_ENST00000450114.2_Missense_Mutation_p.E514K	NM_001143976.1	NP_001137448.1	P30291	WEE1_HUMAN	WEE1 G2 checkpoint kinase	514	Protein kinase.				blood coagulation|cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|S phase of mitotic cell cycle	nucleoplasm	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	23				all cancers(16;4.59e-09)|Epithelial(150;3.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0484)		TGCTGGTGCTGAACCTCTTCC	0.393000													33	106					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25479316	25479316	+	RNA	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:25479316G>T	ENST00000453082.2	+	0	1857					NR_003343.1																						CTGACTCCGTGGTCTCCTGCA	0.597000													26	106					1.85244e-09	2.16409e-09	1	1	0
LARP4	113251	broad.mit.edu	37	12	50829272	50829272	+	Splice_Site	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:50829272G>A	ENST00000398473.2	+	5	512	c.398_splice	c.e5-1	p.E134_splice	LARP4_ENST00000518561.1_Splice_Site_p.E64_splice|LARP4_ENST00000429001.3_Splice_Site_p.E140_splice|LARP4_ENST00000293618.8_Splice_Site_p.E134_splice|LARP4_ENST00000518444.1_Splice_Site_p.E133_splice|LARP4_ENST00000522085.1_Splice_Site_p.E134_splice|LARP4_ENST00000347328.5_Splice_Site_p.E134_splice	NM_052879.4|NM_199188.2	NP_443111.4|NP_954658.2	Q71RC2	LARP4_HUMAN	La ribonucleoprotein domain family, member 4	134	HTH La-type RNA-binding.						nucleotide binding|RNA binding			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						TTTTTTCAGAGAAAATTTGTC	0.303000													10	39					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155260453	155260453	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:155260453G>A	ENST00000392414.3	-	11	1655	c.1542C>T	c.(1540-1542)ttC>ttT	p.F514F	PKLR_ENST00000342741.4_Silent_p.F545F	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	545					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	CAACACGGAGGAAGCCACGGA	0.567000													6	57					0	0	1	0	0
RBFOX1	54715	broad.mit.edu	37	16	7703920	7703920	+	Silent	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:7703920G>T	ENST00000340209.4	+	9	1173	c.876G>T	c.(874-876)gcG>gcT	p.A292A	RBFOX1_ENST00000355637.4_Silent_p.A307A|RBFOX1_ENST00000552089.1_Silent_p.A304A|RBFOX1_ENST00000547338.1_Silent_p.A287A|RBFOX1_ENST00000422070.4_Silent_p.A330A|RBFOX1_ENST00000550418.1_Silent_p.A287A|RBFOX1_ENST00000436368.2_Silent_p.A307A|RBFOX1_ENST00000311745.5_Silent_p.A307A|RBFOX1_ENST00000553186.1_Silent_p.A260A|RBFOX1_ENST00000535565.2_Silent_p.A244A|RBFOX1_ENST00000547372.1_Silent_p.A330A			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	287					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						gggccgcggcgcccccgcccc	0.741000													7	30					5.18039e-06	5.59452e-06	1	1	0
ANGPTL3	27329	broad.mit.edu	37	1	63069891	63069891	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:63069891C>T	ENST00000371129.3	+	6	1263	c.1183C>T	c.(1183-1185)Cca>Tca	p.P395S	ANGPTL3_ENST00000493994.1_3'UTR|DOCK7_ENST00000251157.5_Intron|DOCK7_ENST00000404627.2_Intron|DOCK7_ENST00000340370.5_Intron	NM_014495.2	NP_055310.1	Q9Y5C1	ANGL3_HUMAN	angiopoietin-like 3	395	Fibrinogen C-terminal.				acylglycerol homeostasis|artery morphogenesis|cell-matrix adhesion|cholesterol homeostasis|cholesterol metabolic process|fatty acid metabolic process|glycerol metabolic process|integrin-mediated signaling pathway|lipid storage|negative regulation of lipoprotein lipase activity|negative regulation of phospholipase activity|phospholipid catabolic process|phospholipid homeostasis|positive regulation of angiogenesis|positive regulation of cell migration|positive regulation of lipid catabolic process|triglyceride homeostasis	extracellular space	cell surface binding|growth factor activity|integrin binding|phospholipase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(3)|urinary_tract(1)	13						CTTCAACTGTCCAGAGGGTTA	0.368000													25	83					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8661426	8661426	+	Splice_Site	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:8661426C>A	ENST00000270328.4	-	8	1350	c.1084_splice	c.e8+1	p.G362_splice	ADAMTS10_ENST00000597188.1_Splice_Site_p.G362_splice			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	362	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						GCTCGGGTACCTAGTGTGCCG	0.607000													9	64					0.00448238	0.00461275	1	1	0
C1orf173	127254	broad.mit.edu	37	1	75065496	75065496	+	Missense_Mutation	SNP	T	T	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:75065496T>G	ENST00000326665.5	-	11	1827	c.1609A>C	c.(1609-1611)Aat>Cat	p.N537H	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Missense_Mutation_p.N340H	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	537	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GGGTCTAAATTATCTTTTTTA	0.403000													48	170					0	0	1	0	0
HIPK3	10114	broad.mit.edu	37	11	33375024	33375024	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:33375024C>T	ENST00000303296.4	+	17	3863	c.3558C>T	c.(3556-3558)atC>atT	p.I1186I	HIPK3_ENST00000456517.1_Silent_p.I1165I|HIPK3_ENST00000525975.1_Silent_p.I1165I|HIPK3_ENST00000379016.3_Silent_p.I1165I	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	1186					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						ACAAACCAATCTTCCCACCAC	0.443000													29	113					0	0	1	0	0
YARS2	51067	broad.mit.edu	37	12	32908421	32908421	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:32908421C>T	ENST00000324868.8	-	1	415	c.388G>A	c.(388-390)Gag>Aag	p.E130K		NM_001040436.2	NP_001035526.1	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	130					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	16	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	TCCAGCGCCTCGCGTTCCTTG	0.682000											OREG0021729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	24					0	0	1	0	0
ARFGAP2	84364	broad.mit.edu	37	11	47189740	47189740	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:47189740G>A	ENST00000524782.1	-	11	1232	c.1004C>T	c.(1003-1005)gCa>gTa	p.A335V	ARFGAP2_ENST00000426335.2_Missense_Mutation_p.A199V|ARFGAP2_ENST00000395449.3_5'UTR|ARFGAP2_ENST00000419701.2_Missense_Mutation_p.A228V|ARFGAP2_ENST00000319543.6_Missense_Mutation_p.A66V	NM_001242832.1|NM_032389.4	NP_001229761.1|NP_115765.2	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating protein 2	335	Required for interaction with coatomer.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						AGAGGATTTTGCACTCACTGG	0.532000													20	60					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32036316	32036316	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:32036316C>G	ENST00000375244.3	-	17	6272	c.6071G>C	c.(6070-6072)gGa>gCa	p.G2024A	TNXB_ENST00000375247.2_Missense_Mutation_p.G2024A			P22105	TENX_HUMAN	tenascin XB	2106	Fibronectin type-III 12.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CTGCCCATCTCCATTCCTGTA	0.602000													7	51					0	0	1	0	0
UNC93B1	81622	broad.mit.edu	37	11	67766695	67766695	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:67766695G>A	ENST00000227471.2	-	5	714	c.635C>T	c.(634-636)tCc>tTc	p.S212F	UNC93B1_ENST00000530331.1_5'UTR	NM_030930.2	NP_112192.2	Q9H1C4	UN93B_HUMAN	unc-93 homolog B1 (C. elegans)	212					innate immune response|intracellular protein transport|response to virus|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway	early phagosome|endoplasmic reticulum membrane|endosome|integral to membrane|lysosome											GGGCGCGTGGGAGCCCCGCGG	0.602000													12	44					0	0	1	0	0
ZNF540	163255	broad.mit.edu	37	19	38102542	38102542	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:38102542G>C	ENST00000592533.1	+	5	693	c.361G>C	c.(361-363)Gag>Cag	p.E121Q	ZNF540_ENST00000316433.4_Missense_Mutation_p.E121Q|ZNF540_ENST00000343599.5_Missense_Mutation_p.E121Q|ZNF540_ENST00000589117.1_Missense_Mutation_p.E89Q|ZNF540_ENST00000586792.1_3'UTR	NM_152606.4	NP_689819.1			zinc finger protein 540											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(13)|lung(8)|skin(1)	28			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTTTAGAAATGAGTGGCAGAA	0.318000													36	181					0	0	1	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75928922	75928922	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:75928922A>T	ENST00000262207.4	+	7	1318	c.850A>T	c.(850-852)Ata>Tta	p.I284L	CRISPLD1_ENST00000523524.1_Missense_Mutation_p.I96L|CRISPLD1_ENST00000517786.1_Missense_Mutation_p.I98L	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	284						extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			AAATGAAGTCATAAGCGCACA	0.353000													38	194					0	0	1	0	0
ZNF267	10308	broad.mit.edu	37	16	31926049	31926049	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:31926049A>G	ENST00000300870.10	+	4	688	c.479A>G	c.(478-480)tAt>tGt	p.Y160C	RP11-170L3.8_ENST00000575471.1_RNA	NM_001265588.1|NM_003414.5	NP_001252517.1|NP_003405.3	Q14586	ZN267_HUMAN	zinc finger protein 267	160					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(5)|kidney(1)|large_intestine(14)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	41						GCCAAAAGCTATAACTTTGAT	0.303000													27	55					0	0	1	0	0
GNB5	10681	broad.mit.edu	37	15	52476783	52476783	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:52476783G>C	ENST00000261837.7	-	2	156	c.91C>G	c.(91-93)Caa>Gaa	p.Q31E	RP11-430B1.2_ENST00000560518.1_lincRNA	NM_016194.3	NP_057278.2	O14775	GBB5_HUMAN	guanine nucleotide binding protein (G protein), beta 5	31						heterotrimeric G-protein complex	GTPase activity|signal transducer activity			large_intestine(1)|lung(1)	2				all cancers(107;0.0163)		CTGAGTTGTTGAGACTTCTTG	0.388000													35	79					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25380277	25380277	+	Missense_Mutation	SNP	G	G	C	rs121913238		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:25380277G>C	ENST00000311936.3	-	3	372	c.181C>G	c.(181-183)Caa>Gaa	p.Q61E	KRAS_ENST00000256078.4_Missense_Mutation_p.Q61E|KRAS_ENST00000557334.1_Intron	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	61			Q -> H (in lung carcinoma; dbSNP:rs17851045).|Q -> R (in a colorectal cancer sample; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.Q61K(32)|p.Q61E(10)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TACTCCTCTTGACCTGCTGTG	0.413000	Q61K(CALU6_LUNG)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			5	71					0	0	1	0	0
ITIH4	3700	broad.mit.edu	37	3	52847505	52847505	+	Splice_Site	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:52847505C>G	ENST00000266041.4	-	24	2821	c.2723_splice	c.e24-1	p.E909_splice	ITIH4_ENST00000406595.1_Splice_Site_p.E879_splice|ITIH4_ENST00000485816.1_Splice_Site_p.E914_splice|ITIH4_ENST00000346281.5_Splice_Site_p.E893_splice	NM_002218.4	NP_002209.2	Q14624	ITIH4_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 4	909					acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		AGCCTGCGCTCTCTGAAATGG	0.577000													17	63					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138451878	138451878	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:138451878G>A	ENST00000344876.4	-	1	1751	c.1365C>T	c.(1363-1365)atC>atT	p.I455I	PCDH18_ENST00000511115.1_Intron|PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000507846.1_Silent_p.I235I|PCDH18_ENST00000412923.2_Silent_p.I455I	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	455	Cadherin 4.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					TGATATCATTGATTTGAACTG	0.408000													26	154					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158906918	158906918	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:158906918C>A	ENST00000368140.1	+	2	463	c.218C>A	c.(217-219)cCa>cAa	p.P73Q	PYHIN1_ENST00000392254.2_Missense_Mutation_p.P73Q|PYHIN1_ENST00000392252.3_Missense_Mutation_p.P73Q|PYHIN1_ENST00000368135.4_Missense_Mutation_p.P73Q|PYHIN1_ENST00000368138.3_Missense_Mutation_p.P73Q	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	73	DAPIN.				cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					AAAGAAATACCAACACTGGGA	0.423000													15	102					6.31663e-08	7.15435e-08	1	1	0
SIGLEC1	6614	broad.mit.edu	37	20	3684093	3684093	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:3684093C>T	ENST00000344754.4	-	5	978	c.979G>A	c.(979-981)Gag>Aag	p.E327K	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.E327K	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	327	Ig-like C2-type 3.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						ACCTGGACCTCAGCCACTGCA	0.607000													12	50					0	0	1	0	0
MVK	4598	broad.mit.edu	37	12	110029114	110029114	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:110029114G>A	ENST00000228510.3	+	9	913	c.837G>A	c.(835-837)ctG>ctA	p.L279L	MVK_ENST00000539696.1_5'UTR|MVK_ENST00000539575.1_Silent_p.L227L|MVK_ENST00000392727.3_Silent_p.L227L|MVK_ENST00000541384.1_Silent_p.L85L	NM_000431.2|NM_001114185.1	NP_000422.1|NP_001107657.1	Q03426	KIME_HUMAN	mevalonate kinase	279					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|peroxisome	ATP binding|identical protein binding|mevalonate kinase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	8						AGCGCGTGCTGGGAGAGATGG	0.592000													12	60					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922997	24922997	+	Silent	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:24922997C>A	ENST00000329468.2	+	1	2457	c.1983C>A	c.(1981-1983)ctC>ctA	p.L661L		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		AAGCTTCTCTCCCCAGTGCCT	0.512000													22	142					3.5997e-14	4.44282e-14	1	1	0
MGRN1	23295	broad.mit.edu	37	16	4731653	4731653	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:4731653G>A	ENST00000399577.5	+	13	1327	c.1234G>A	c.(1234-1236)Gaa>Aaa	p.E412K	MGRN1_ENST00000588994.1_Missense_Mutation_p.E390K|MGRN1_ENST00000415496.1_Missense_Mutation_p.E391K|MGRN1_ENST00000262370.7_Missense_Mutation_p.E412K|MGRN1_ENST00000586183.1_Missense_Mutation_p.E390K	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase	412					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						CCCTCTTTATGAAGAAATCAC	0.652000													19	62					0	0	1	0	0
TESK1	7016	broad.mit.edu	37	9	35607664	35607664	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:35607664G>A	ENST00000336395.5	+	6	956	c.706G>A	c.(706-708)Gag>Aag	p.E236K	TESK1_ENST00000498522.1_3'UTR	NM_006285.2	NP_006276.2	Q15569	TESK1_HUMAN	testis-specific kinase 1	236	Protein kinase.				cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	27			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCTGTATGATGAGAAGGTGAG	0.577000													15	57					0	0	1	0	0
GRIK4	2900	broad.mit.edu	37	11	120838024	120838024	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:120838024G>C	ENST00000527524.2	+	19	2674	c.2387G>C	c.(2386-2388)aGa>aCa	p.R796T	GRIK4_ENST00000438375.2_Missense_Mutation_p.R796T			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	796					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GAAGATCACAGAGCTAAAGGT	0.512000													5	40					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38121046	38121046	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:38121046C>G	ENST00000406386.3	+	7	2738	c.2483C>G	c.(2482-2484)tCt>tGt	p.S828C	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	828					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AGATCATCTTCTACCCAACAA	0.507000													6	121					0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7480459	7480459	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:7480459G>A	ENST00000399429.3	-	21	1824	c.1684C>T	c.(1684-1686)Caa>Taa	p.Q562*		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	562	Collagen-like 5.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		CTCTGTCCTTGATTTCCTTTG	0.403000													7	92					0	0	1	0	0
DCLRE1C	64421	broad.mit.edu	37	10	14950876	14950876	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:14950876G>A	ENST00000453695.2	-	14	1694	c.1250C>T	c.(1249-1251)tCt>tTt	p.S417F	DCLRE1C_ENST00000378249.1_Missense_Mutation_p.S422F|DCLRE1C_ENST00000378255.1_Missense_Mutation_p.S417F|DCLRE1C_ENST00000357717.2_Missense_Mutation_p.S422F|DCLRE1C_ENST00000378242.1_Missense_Mutation_p.S190F|DCLRE1C_ENST00000396817.2_Missense_Mutation_p.S417F|DCLRE1C_ENST00000378258.1_Missense_Mutation_p.S417F|DCLRE1C_ENST00000378246.2_Missense_Mutation_p.S422F|DCLRE1C_ENST00000378289.4_Intron|DCLRE1C_ENST00000492201.1_5'UTR|DCLRE1C_ENST00000378278.2_Missense_Mutation_p.S537F|DCLRE1C_ENST00000378254.1_Missense_Mutation_p.S417F	NM_001033855.1	NP_001029027.1	Q96SD1	DCR1C_HUMAN	DNA cross-link repair 1C	537					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	17						TGACTGGGAAGAATTCTGGGA	0.458000								Non-homologous end-joining					15	81					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1219335	1219335	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:1219335G>T	ENST00000326873.7	+	3	1560	c.387G>T	c.(385-387)atG>atT	p.M129I	STK11_ENST00000585748.1_3'UTR	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	129	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		ATATGGTGATGGAGTACTGCG	0.667000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			4	5					0.00909568	0.00925766	1	1	0
ARHGAP20	57569	broad.mit.edu	37	11	110451175	110451175	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:110451175G>T	ENST00000260283.4	-	16	2779	c.2495C>A	c.(2494-2496)aCa>aAa	p.T832K	ARHGAP20_ENST00000357139.3_Missense_Mutation_p.T806K|ARHGAP20_ENST00000533353.1_Missense_Mutation_p.T806K|ARHGAP20_ENST00000528829.1_Missense_Mutation_p.T796K|ARHGAP20_ENST00000527598.1_Missense_Mutation_p.T796K|ARHGAP20_ENST00000529591.1_Missense_Mutation_p.T375K|ARHGAP20_ENST00000524756.1_Missense_Mutation_p.T809K	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	832					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GGCATCTGCTGTGTGTGGTGG	0.502000													25	96					4.26978e-12	5.10861e-12	1	1	0
ERC1	23085	broad.mit.edu	37	12	1192399	1192399	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:1192399C>T	ENST00000397203.2	+	3	1145	c.739C>T	c.(739-741)Cag>Tag	p.Q247*	ERC1_ENST00000546231.2_Nonsense_Mutation_p.Q247*|ERC1_ENST00000360905.4_Nonsense_Mutation_p.Q247*|ERC1_ENST00000355446.5_Nonsense_Mutation_p.Q247*|ERC1_ENST00000589028.1_Nonsense_Mutation_p.Q247*|ERC1_ENST00000543086.3_Nonsense_Mutation_p.Q247*			Q8IUD2	RB6I2_HUMAN	ELKS/RAB6-interacting/CAST family member 1	247					I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			NS(1)|breast(2)|cervix(2)|endometrium(2)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			TCAGCTGTTTCAGCAGGATAG	0.507000													13	107					0	0	1	0	0
RWDD2B	10069	broad.mit.edu	37	21	30378926	30378926	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr21:30378926C>T	ENST00000493196.1	-	5	872	c.772G>A	c.(772-774)Gac>Aac	p.D258N	RWDD2B_ENST00000486719.1_5'UTR	NM_016940.2	NP_058636.1	P57060	RWD2B_HUMAN	RWD domain containing 2B	258										endometrium(1)|kidney(1)|large_intestine(8)|lung(2)	12						AAAGGAATGTCTTCTCGATGG	0.323000													4	40					0	0	1	0	0
TESK1	7016	broad.mit.edu	37	9	35607591	35607591	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:35607591G>T	ENST00000336395.5	+	6	883	c.633G>T	c.(631-633)agG>agT	p.R211S	TESK1_ENST00000498522.1_3'UTR	NM_006285.2	NP_006276.2	Q15569	TESK1_HUMAN	testis-specific kinase 1	211	Protein kinase.				cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	27			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AGGGGGCAAGGAAGGAGCCAT	0.592000													19	99					2.37509e-13	2.8882e-13	1	1	0
ERN2	10595	broad.mit.edu	37	16	23711921	23711921	+	Silent	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:23711921C>A	ENST00000256797.4	-	13	1776	c.1608G>T	c.(1606-1608)cgG>cgT	p.R536R	ERN2_ENST00000457008.2_Silent_p.R436R	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	488	Protein kinase.				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TCTGGCTCCTCCGGCTGGCCC	0.622000													39	102					4.17593e-13	5.06153e-13	1	1	0
ZBED4	9889	broad.mit.edu	37	22	50278846	50278846	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:50278846G>A	ENST00000216268.4	+	2	2013	c.1536G>A	c.(1534-1536)caG>caA	p.Q512Q		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	512						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		TCGGGAGCCAGAAGGGCTTCC	0.567000													25	111					0	0	1	0	0
MGAT4B	11282	broad.mit.edu	37	5	179225254	179225254	+	Missense_Mutation	SNP	C	C	G	rs138931499		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:179225254C>G	ENST00000337755.5	-	13	2465	c.1579G>C	c.(1579-1581)Gag>Cag	p.E527Q	MGAT4B_ENST00000292591.7_Missense_Mutation_p.E512Q	NM_054013.3	NP_463459.1	Q9UQ53	MGT4B_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B	512					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	13	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACCTCTCCCTCTGCCACTCCC	0.647000													9	13					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14775721	14775721	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:14775721G>A	ENST00000403951.2	-	5	686	c.267C>T	c.(265-267)aaC>aaT	p.N89N	DGKB_ENST00000399322.3_Silent_p.N89N|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Silent_p.N89N|DGKB_ENST00000407950.1_Silent_p.N82N|DGKB_ENST00000406247.3_Silent_p.N89N|DGKB_ENST00000402815.1_Silent_p.N89N|DGKB_ENST00000444700.2_Silent_p.N82N			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	89					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	GAGGAAACTTGTTGCTAAATG	0.358000													5	17					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1980533	1980533	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:1980533C>T	ENST00000382895.3	+	24	4426	c.3995C>T	c.(3994-3996)tCg>tTg	p.S1332L	WHSC1_ENST00000508803.1_Missense_Mutation_p.S1332L|WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382888.3_Missense_Mutation_p.S680L|WHSC1_ENST00000382891.5_Missense_Mutation_p.S1332L|WHSC1_ENST00000382892.2_Missense_Mutation_p.S1332L	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	1332					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GGGGCGGCATCGGTCAGAAGC	0.647000			T	IGH@	MM								11	40					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90144605	90144605	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:90144605G>A	ENST00000268138.7	+	10	2335	c.2230G>A	c.(2230-2232)Gaa>Aaa	p.E744K	TICRR_ENST00000560985.1_Missense_Mutation_p.E743K					TOPBP1-interacting checkpoint and replication regulator																		AGATGATATGGAACAAGTAGT	0.418000													17	79					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234858761	234858761	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:234858761G>A	ENST00000324695.4	+	9	1151	c.1111G>A	c.(1111-1113)Gag>Aag	p.E371K	TRPM8_ENST00000433712.2_Missense_Mutation_p.E59K|AC005538.5_ENST00000455991.1_RNA	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	371						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CCGGCTGCCTGAGGAGGAGAC	0.537000													4	21					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6128883	6128883	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:6128883C>A	ENST00000261405.5	-	28	3955	c.3701G>T	c.(3700-3702)tGt>tTt	p.C1234F		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1234					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GCAGGCTTCACAGGTGAGGTT	0.557000													8	20					0.00307968	0.00317806	1	1	0
LOC440040	440040	broad.mit.edu	37	11	49831554	49831554	+	RNA	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:49831554G>T	ENST00000527477.1	+	0	1779																											TATATATGGAGAGGAGGGACT	0.453000													18	46					5.03518e-11	5.96673e-11	1	1	0
RGP1	9827	broad.mit.edu	37	9	35752111	35752111	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:35752111C>T	ENST00000378078.4	+	8	1062	c.921C>T	c.(919-921)ctC>ctT	p.L307L	RGP1_ENST00000456972.2_Silent_p.L347L	NM_001080496.2	NP_001073965.2	Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog (S. cerevisiae)	307								p.L307L(1)|p.L347L(1)		cervix(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	14	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CAATCCCTCTCAGCTCCACCC	0.567000													10	34					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134884458	134884458	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:134884458G>T	ENST00000607359.1	+	1	26	c.26G>T	c.(25-27)cGg>cTg	p.R9L				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		AACCACTCGCGGCTGAAATCC	0.647000													5	13					3.59834e-05	3.83582e-05	1	1	0
STAB1	23166	broad.mit.edu	37	3	52543237	52543237	+	Silent	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:52543237G>C	ENST00000321725.6	+	22	2323	c.2247G>C	c.(2245-2247)ggG>ggC	p.G749G		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	749	EGF-like 5.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCAGTGATGGGATCCAGGGCA	0.572000													7	44					0	0	1	0	0
KIF24	347240	broad.mit.edu	37	9	34311019	34311019	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:34311019C>T	ENST00000379166.2	-	2	445	c.326G>A	c.(325-327)aGa>aAa	p.R109K	KIF24_ENST00000345050.2_Missense_Mutation_p.R109K|KIF24_ENST00000379174.3_Missense_Mutation_p.R109K|KIF24_ENST00000402558.2_Missense_Mutation_p.R109K	NM_194313.2	NP_919289.2	Q5T7B8	KIF24_HUMAN	kinesin family member 24	109			R -> G (in dbSNP:rs41274845).		microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(13)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	32			LUSC - Lung squamous cell carcinoma(29;0.0107)			GCTGGCATTTCTGTCTTTATT	0.428000													9	44					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112616996	112616996	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:112616996C>T	ENST00000550722.1	-	63	11150	c.10755G>A	c.(10753-10755)ctG>ctA	p.L3585L	HECTD4_ENST00000430131.2_Silent_p.L3309L|HECTD4_ENST00000377560.5_Silent_p.L3559L	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GCTGATCCTCCAGCACCTTTT	0.602000													8	18					0	0	1	0	0
ELP6	54859	broad.mit.edu	37	3	47539857	47539857	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:47539857C>T	ENST00000296149.4	-	6	761	c.591G>A	c.(589-591)ctG>ctA	p.L197L	ELP6_ENST00000446787.1_Silent_p.L124L|ELP6_ENST00000439305.1_Silent_p.L124L	NM_001031703.2	NP_001026873.2			elongator acetyltransferase complex subunit 6																		TGAGGCCATTCAGCAGGATGT	0.577000													34	65					0	0	1	0	0
SMUG1	23583	broad.mit.edu	37	12	54577482	54577482	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:54577482G>A	ENST00000505128.1	-	3	365	c.243C>T	c.(241-243)ttC>ttT	p.F81F	SMUG1_ENST00000505662.1_Intron|SMUG1_ENST00000514685.1_Silent_p.F81F|SMUG1_ENST00000401977.2_Silent_p.F81F|SMUG1_ENST00000243112.5_Silent_p.F81F|SMUG1_ENST00000508394.2_Silent_p.F81F|SMUG1_ENST00000513838.1_Silent_p.F81F|SMUG1_ENST00000514196.1_Silent_p.F81F|SMUG1_ENST00000337581.3_Silent_p.F81F|SMUG1_ENST00000506595.1_Silent_p.F81F			Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional uracil-DNA glycosylase 1	81				Missing (in Ref. 3; BAC03670).	depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity			kidney(1)|large_intestine(4)|lung(1)	6						TCATGCCCAGGAAGAGTACTT	0.587000								Base excision repair (BER), DNA glycosylases					5	52					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588854	247588854	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:247588854G>T	ENST00000366497.2	+	4	2889	c.2109G>T	c.(2107-2109)atG>atT	p.M703I	NLRP3_ENST00000348069.2_Missense_Mutation_p.M703I|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000391827.2_Missense_Mutation_p.M703I|NLRP3_ENST00000366496.2_Missense_Mutation_p.M703I|NLRP3_ENST00000391828.3_Missense_Mutation_p.M703I|NLRP3_ENST00000336119.3_Missense_Mutation_p.M703I	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	703					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			ACCTTGATATGGTGCAGTGTG	0.547000													14	83					7.93312e-07	8.74527e-07	1	1	0
SMOX	54498	broad.mit.edu	37	20	4163347	4163347	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:4163347G>A	ENST00000305958.4	+	5	1446	c.1221G>A	c.(1219-1221)aaG>aaA	p.K407K	SMOX_ENST00000339123.6_Silent_p.K354K|SMOX_ENST00000278795.3_Silent_p.K354K|SMOX_ENST00000379460.2_Silent_p.K407K|SMOX_ENST00000346595.2_Intron	NM_175839.1	NP_787033.1	Q9NWM0	SMOX_HUMAN	spermine oxidase	407					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(7)|lung(5)|skin(2)|urinary_tract(1)	26					Spermine(DB00127)	GGTACCGCAAGATCTGCGGCT	0.612000													18	46					0	0	1	0	0
MISP	126353	broad.mit.edu	37	19	757003	757003	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:757003C>T	ENST00000215582.6	+	2	160	c.57C>T	c.(55-57)acC>acT	p.T19T		NM_173481.2	NP_775752.1			mitotic spindle positioning																		ACCGTGGCACCGGCCTGGTGC	0.662000													4	15					0	0	1	0	0
IKBKAP	8518	broad.mit.edu	37	9	111658818	111658818	+	Silent	SNP	A	A	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:111658818A>G	ENST00000374647.5	-	25	3001	c.2694T>C	c.(2692-2694)taT>taC	p.Y898Y	IKBKAP_ENST00000537196.1_Silent_p.Y549Y	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	898					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AATCAAAGTCATAGGTGCCAA	0.393000													21	82					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	17978481	17978481	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:17978481G>A	ENST00000262608.8	+	3	322	c.322G>A	c.(322-324)Gaa>Aaa	p.E108K	CECR2_ENST00000400573.4_Missense_Mutation_p.E127K|CECR2_ENST00000342247.5_Missense_Mutation_p.E107K|CECR2_ENST00000400585.2_5'UTR|CECR2_ENST00000497534.1_3'UTR	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	149					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		GCCATTGGGTGAAGACAATTC	0.488000													16	42					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3684575	3684575	+	Silent	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:3684575C>A	ENST00000344754.4	-	4	869	c.870G>T	c.(868-870)ctG>ctT	p.L290L	SIGLEC1_ENST00000202578.4_Silent_p.L290L	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	290	Ig-like C2-type 2.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GGGGCAGGTGCAGCACACCAG	0.597000													6	56					8.12818e-05	8.62749e-05	1	1	0
SYT10	341359	broad.mit.edu	37	12	33579171	33579171	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:33579171G>A	ENST00000228567.3	-	2	707	c.411C>T	c.(409-411)tcC>tcT	p.S137S	SYT10_ENST00000535526.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	137						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GGATGTCAGGGGAAGTGTGGC	0.393000													31	204					0	0	1	0	0
FGFR3	2261	broad.mit.edu	37	4	1808320	1808320	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:1808320C>G	ENST00000340107.4	+	16	2340	c.2084C>G	c.(2083-2085)tCc>tGc	p.S695C	FGFR3_ENST00000412135.2_Missense_Mutation_p.S581C|FGFR3_ENST00000440486.2_Missense_Mutation_p.S693C|FGFR3_ENST00000481110.2_Silent_p.L670L|FGFR3_ENST00000352904.1_Missense_Mutation_p.S581C|FGFR3_ENST00000260795.2_Missense_Mutation_p.S693C	NM_001163213.1	NP_001156685.1	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3	693	Protein kinase.				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding			NS(1)|central_nervous_system(5)|cervix(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(40)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(9)|skin(339)|soft_tissue(4)|testis(2)|upper_aerodigestive_tract(58)|urinary_tract(2607)	3091		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CTGGGGGGCTCCCCGTACCCC	0.637000		1	"""Mis, T"""	"""IGH@, ETV6"""	"""bladder, MM, T-cell lymphoma"""		"""Hypochondroplasia, Thanatophoric dysplasia"""		Saethre-Chotzen syndrome;Muenke syndrome				7	37					0	0	1	0	0
C3orf58	205428	broad.mit.edu	37	3	143704687	143704687	+	Splice_Site	SNP	A	A	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:143704687A>T	ENST00000315691.3	+	2	1495	c.961_splice	c.e2+1	p.Q320_splice	C3orf58_ENST00000495414.1_Splice_Site_p.Q111_splice|C3orf58_ENST00000441925.2_Splice_Site_p.Q82_splice|C3orf58_ENST00000493396.1_Intron	NM_173552.3	NP_775823.1	Q8NDZ4	CC058_HUMAN	chromosome 3 open reading frame 58	320						COPI vesicle coat|extracellular region				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TAATTAGACAAAGTAAGTATA	0.313000													20	66					0	0	1	0	0
CCDC54	84692	broad.mit.edu	37	3	107097305	107097305	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:107097305C>T	ENST00000261058.1	+	1	1118	c.871C>T	c.(871-873)Cag>Tag	p.Q291*		NM_032600.2	NP_115989.1	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	291										NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	19						GGTCATAACCCAGAGATACTG	0.418000													28	99					0	0	1	0	0
CASP10	843	broad.mit.edu	37	2	202050731	202050731	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:202050731C>A	ENST00000286186.6	+	2	666	c.231C>A	c.(229-231)ttC>ttA	p.F77L	CASP10_ENST00000448480.1_Missense_Mutation_p.F77L|CASP10_ENST00000374650.3_Missense_Mutation_p.F77L|CASP10_ENST00000360132.3_Missense_Mutation_p.F77L|CASP10_ENST00000272879.5_Missense_Mutation_p.F77L|CASP10_ENST00000313728.7_Missense_Mutation_p.F77L|CASP10_ENST00000346817.5_Missense_Mutation_p.F77L|CASP10_ENST00000492363.1_3'UTR	NM_032977.3	NP_116759.2	Q92851	CASPA_HUMAN	caspase 10, apoptosis-related cysteine peptidase	77	DED 1.				apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27						AAGACCCTTTCTTCCTGGCAG	0.512000													7	54					8.12818e-05	8.62749e-05	1	1	0
ARMCX1	51309	broad.mit.edu	37	X	100809149	100809149	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chrX:100809149C>T	ENST00000372829.3	+	4	1607	c.1236C>T	c.(1234-1236)ttC>ttT	p.F412F		NM_016608.1	NP_057692.1	Q9P291	ARMX1_HUMAN	armadillo repeat containing, X-linked 1	412						integral to membrane	binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(2)|ovary(3)|pancreas(1)|urinary_tract(1)	19						GGAAAGAATTCAGCAGAAGTT	0.338000													23	29					0	0	1	0	0
THAP7-AS1	439931	broad.mit.edu	37	22	21363392	21363392	+	RNA	SNP	G	G	A	rs28522842	by1000genomes	TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:21363392G>A	ENST00000452284.1	+	0	1059				THAP7-AS1_ENST00000436079.1_RNA|TUBA3FP_ENST00000422086.1_RNA	NR_027051.1																						GGGCCCCATCGAATCACAGGG	0.562000													5	87					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	20959395	20959395	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:20959395G>T	ENST00000298925.5	+	11	1298	c.1145G>T	c.(1144-1146)cGg>cTg	p.R382L	NELL1_ENST00000532434.1_Missense_Mutation_p.R354L|NELL1_ENST00000325319.5_Missense_Mutation_p.R297L|NELL1_ENST00000357134.5_Missense_Mutation_p.R354L			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	354	VWFC 2.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						AAGAGCTGTCGGGAATGCCGA	0.408000													10	95					1.08611e-07	1.21533e-07	1	1	0
LUZP2	338645	broad.mit.edu	37	11	24759829	24759829	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:24759829C>A	ENST00000533227.1	+	4	343	c.56C>A	c.(55-57)gCa>gAa	p.A19E	LUZP2_ENST00000531187.1_3'UTR|LUZP2_ENST00000336930.6_Missense_Mutation_p.A105E	NM_001009909.3|NM_001252008.1	NP_001009909.2|NP_001238937.1	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2	105						extracellular region				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(11)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	32						TCAGAGAAAGCAGAAAAACAC	0.378000													8	49					3.09899e-07	3.44693e-07	1	1	0
OR5R1	219479	broad.mit.edu	37	11	56185378	56185378	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:56185378C>A	ENST00000312253.1	-	1	330	c.331G>T	c.(331-333)Gag>Tag	p.E111*		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					AGGAAACACTCAGTGATCATG	0.453000													14	78					3.27435e-08	3.72564e-08	1	1	0
CUL2	8453	broad.mit.edu	37	10	35333508	35333508	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:35333508G>A	ENST00000374748.1	-	9	1013	c.700C>T	c.(700-702)Cag>Tag	p.Q234*	CUL2_ENST00000374749.3_Nonsense_Mutation_p.Q234*|CUL2_ENST00000374742.1_Nonsense_Mutation_p.Q234*|CUL2_ENST00000602371.1_Nonsense_Mutation_p.Q177*|CUL2_ENST00000374751.3_Nonsense_Mutation_p.Q234*|CUL2_ENST00000537177.1_Nonsense_Mutation_p.Q253*|CUL2_ENST00000374746.1_Nonsense_Mutation_p.Q234*			Q13617	CUL2_HUMAN	cullin 2	234					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|prostate(2)|skin(1)|urinary_tract(2)	31						TCCATATACTGTGAGCAGTTT	0.303000													22	62					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160742944	160742944	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:160742944G>A	ENST00000263636.4	-	5	927	c.900C>T	c.(898-900)ctC>ctT	p.L300L	LY75_ENST00000554112.1_Silent_p.L300L|LY75_ENST00000553424.1_Silent_p.L300L|LY75-CD302_ENST00000505052.1_Silent_p.L300L|LY75-CD302_ENST00000504764.1_Silent_p.L300L	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		GATCCCAGTTGAGAAAGTTTA	0.408000													13	83					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67023852	67023852	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:67023852G>A	ENST00000340001.4	-	13	1931	c.1720C>T	c.(1720-1722)Ctc>Ttc	p.L574F	ABCA9_ENST00000453985.2_Missense_Mutation_p.L574F|ABCA9_ENST00000370732.2_Missense_Mutation_p.L574F	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	574	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TTCACAGTGAGAAATCCAAAT	0.373000													19	84					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124882710	124882710	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:124882710C>T	ENST00000356219.3	-	17	1986	c.1831G>A	c.(1831-1833)Gag>Aag	p.E611K	NCOR2_ENST00000429285.2_Missense_Mutation_p.E610K|NCOR2_ENST00000404621.1_Missense_Mutation_p.E610K|NCOR2_ENST00000397355.1_Missense_Mutation_p.E611K|NCOR2_ENST00000404121.2_Missense_Mutation_p.E181K|NCOR2_ENST00000405201.1_Missense_Mutation_p.E611K	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	611	SANT 2.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CGAGAACTCTCATTCAGCTCC	0.532000													12	75					0	0	1	0	0
HCK	3055	broad.mit.edu	37	20	30672297	30672297	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:30672297C>T	ENST00000534862.1	+	9	1089	c.726C>T	c.(724-726)ctC>ctT	p.L242L	HCK_ENST00000375852.2_Silent_p.L262L|HCK_ENST00000538448.1_Silent_p.L241L|HCK_ENST00000520553.1_Silent_p.L241L|HCK_ENST00000518730.1_Silent_p.L240L|HCK_ENST00000375862.2_Silent_p.L261L	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	262					interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGGAATCCCTCAAGCTGGAGA	0.612000													5	71					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21479329	21479329	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr18:21479329G>T	ENST00000313654.9	+	47	6155	c.5914G>T	c.(5914-5916)Gaa>Taa	p.E1972*	LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000587184.1_Intron|LAMA3_ENST00000399516.3_Intron|LAMA3_ENST00000269217.6_Nonsense_Mutation_p.E363*	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1972	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAGTGGGCTGAAGCCCAGCG	0.488000													10	47					7.48243e-07	8.27298e-07	1	1	0
SNX10	29887	broad.mit.edu	37	7	26411631	26411631	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:26411631G>A	ENST00000338523.4	+	6	689	c.502G>A	c.(502-504)Gat>Aat	p.D168N	SNX10_ENST00000409367.1_Missense_Mutation_p.D128N|SNX10_ENST00000409838.1_Missense_Mutation_p.D84N|SNX10_ENST00000462993.1_3'UTR|SNX10_ENST00000396376.1_Missense_Mutation_p.D168N|SNX10_ENST00000446848.2_Missense_Mutation_p.D194N	NM_001199835.1|NM_013322.2	NP_001186764.1|NP_037454.2	Q9Y5X0	SNX10_HUMAN	sorting nexin 10	168					cell communication|endosome organization|protein transport	extrinsic to endosome membrane	1-phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	6						AAAAGAAAATGATATAGATTA	0.308000													7	65					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1600576	1600576	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:1600576G>A	ENST00000381605.4	-	1	79	c.15C>T	c.(13-15)gcC>gcT	p.A5A	SIRPB1_ENST00000568365.1_Silent_p.A5A|RP4-576H24.4_ENST00000564763.1_Silent_p.A5A|SIRPB1_ENST00000279477.7_Silent_p.A5A|SIRPB1_ENST00000381596.1_5'UTR|SIRPB1_ENST00000381603.3_Silent_p.A5A	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	5					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						GGGGCCAGGAGGCTGGCACGG	0.562000													5	51					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1265843	1265843	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:1265843C>T	ENST00000447027.1	+	31	7800	c.7742C>T	c.(7741-7743)aCa>aTa	p.T2581I	MUC5B_ENST00000529681.1_Missense_Mutation_p.T2578I|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2578	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACACCTCCACAGTGCTTACC	0.642000													36	137					0	0	1	0	0
MCM8	84515	broad.mit.edu	37	20	5948643	5948643	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:5948643G>T	ENST00000378896.3	+	10	1572	c.1195G>T	c.(1195-1197)Gaa>Taa	p.E399*	MCM8_ENST00000378883.1_Nonsense_Mutation_p.E399*|MCM8_ENST00000265187.4_Nonsense_Mutation_p.E383*|MCM8_ENST00000378886.2_Nonsense_Mutation_p.E399*	NM_032485.4|NM_182802.1	NP_115874.3|NP_877954.1	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	399					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	23						GATTCAAGCTGAAGAAAACCT	0.378000													46	114					6.14515e-18	7.76504e-18	1	1	0
CITED1	4435	broad.mit.edu	37	X	71522722	71522722	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chrX:71522722C>T	ENST00000431381.1	-	3	273	c.76G>A	c.(76-78)Gaa>Aaa	p.E26K	CITED1_ENST00000246139.5_5'UTR|CITED1_ENST00000373619.3_5'UTR|CITED1_ENST00000445983.1_5'UTR	NM_001144885.1	NP_001138357.1	Q99966	CITE1_HUMAN	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	0					apoptosis|branching involved in ureteric bud morphogenesis|cell proliferation|melanin biosynthetic process|melanocyte differentiation|mesenchymal to epithelial transition|metanephros development|negative regulation of neuron apoptosis|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|nucleocytoplasmic transport|placenta development|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to cAMP|response to estrogen stimulus|response to insulin stimulus|response to interferon-gamma|response to interleukin-1|response to interleukin-11|response to interleukin-2|response to interleukin-4|response to interleukin-6|response to interleukin-9|response to lipopolysaccharide|response to parathyroid hormone stimulus|response to transforming growth factor beta stimulus|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	chromatin binding|co-SMAD binding|LBD domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			skin(1)	1	Renal(35;0.156)					GTTGGCATTTCAGAGCCTTGG	0.517000													7	7					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	179959751	179959751	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:179959751G>C	ENST00000367607.3	+	4	648	c.230G>C	c.(229-231)aGa>aCa	p.R77T		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	77						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						AAAATAAGTAGAAAAGGTATG	0.348000													4	13					0	0	1	0	0
NPY4R	5540	broad.mit.edu	37	10	47087676	47087676	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:47087676G>A	ENST00000374312.1	+	3	1312	c.893G>A	c.(892-894)tGc>tAc	p.C298Y	NPY4R_ENST00000395716.1_Missense_Mutation_p.C298Y	NM_005972.4	NP_005963.3			neuropeptide Y receptor Y4																		ATCCCCATCTGCCACGGGAAC	0.552000													5	82					0	0	1	0	0
NRDE2	55051	broad.mit.edu	37	14	90770363	90770363	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr14:90770363G>A	ENST00000354366.3	-	5	1153	c.921C>T	c.(919-921)ctC>ctT	p.L307L	NRDE2_ENST00000357904.3_Silent_p.L76L	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		CCTTGGCCTTGAGAGCCGCAC	0.537000													26	107					0	0	1	0	0
ZNF749	388567	broad.mit.edu	37	19	57953345	57953345	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:57953345G>A	ENST00000334181.4	+	2	358	c.108G>A	c.(106-108)gtG>gtA	p.V36V	AC004076.9_ENST00000596831.1_Intron	NM_001023561.2	NP_001018855.2	O43361	ZN749_HUMAN	zinc finger protein 749	36	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|lung(3)|prostate(1)	13		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		ACAGCAATGTGATGTTGGAGA	0.453000													21	148					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82868655	82868655	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:82868655C>T	ENST00000298281.4	+	1	626	c.174C>T	c.(172-174)atC>atT	p.I58I		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	58	CID.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						TCTCTCTCATCGAGGCCCAAA	0.517000													21	107					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	37035918	37035918	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:37035918G>A	ENST00000379242.3	+	15	1995	c.1693G>A	c.(1693-1695)Gac>Aac	p.D565N	VIT_ENST00000401530.1_Missense_Mutation_p.D529N|VIT_ENST00000379241.3_Missense_Mutation_p.D528N|VIT_ENST00000389975.3_Missense_Mutation_p.D550N|VIT_ENST00000404084.1_Missense_Mutation_p.D502N|VIT_ENST00000497382.1_Missense_Mutation_p.D219N	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	550	VWFA 2.					proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				GTTTGGGTTCGACAAGTACAG	0.582000													12	66					0	0	1	0	0
ZHX1	11244	broad.mit.edu	37	8	124266021	124266021	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:124266021C>G	ENST00000395571.3	-	3	2783	c.2166G>C	c.(2164-2166)tgG>tgC	p.W722C	ZHX1-C8ORF76_ENST00000357082.4_Intron|ZHX1_ENST00000297857.2_Missense_Mutation_p.W722C|ZHX1_ENST00000522655.1_Missense_Mutation_p.W722C	NM_001017926.2|NM_007222.4	NP_001017926.1|NP_009153.3	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	722					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			AGTAGTAGTACCATTTCAAGT	0.463000													28	96					0	0	1	0	0
C9orf171	389799	broad.mit.edu	37	9	135413007	135413007	+	Missense_Mutation	SNP	G	G	A	rs147127318		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:135413007G>A	ENST00000343036.2	+	5	700	c.652G>A	c.(652-654)Gat>Aat	p.D218N	C9orf171_ENST00000393216.2_Missense_Mutation_p.D182N	NM_207417.1	NP_997300.1	Q6ZQR2	CI171_HUMAN	chromosome 9 open reading frame 171	218										large_intestine(7)|lung(9)|ovary(4)|prostate(3)	23						ACCCTTCTTTGATCTGCTGCA	0.602000													16	85					0	0	1	0	0
MAPT	4137	broad.mit.edu	37	17	44101405	44101405	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:44101405G>A	ENST00000344290.5	+	15	2521	c.2199G>A	c.(2197-2199)gtG>gtA	p.V733V	MAPT_ENST00000574436.1_Silent_p.V398V|MAPT_ENST00000262410.5_Silent_p.V715V|MAPT_ENST00000576518.1_Silent_p.V298V|MAPT_ENST00000415613.2_Silent_p.V733V|MAPT_ENST00000446361.3_Silent_p.V340V|MAPT_ENST00000535772.1_Silent_p.V367V|MAPT_ENST00000431008.3_Silent_p.V367V|MAPT_ENST00000347967.5_Silent_p.V273V|MAPT_ENST00000420682.2_Silent_p.V369V|MAPT_ENST00000340799.5_Silent_p.V369V|MAPT_ENST00000571987.1_Silent_p.V715V|MAPT_ENST00000351559.5_Silent_p.V398V|MAPT_ENST00000334239.8_Silent_p.V309V	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	715					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				AGTCGCCAGTGGTGTCTGGGG	0.597000													34	112					0	0	1	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431372	56431372	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:56431372C>A	ENST00000302969.2	+	1	235	c.211C>A	c.(211-213)Ctg>Atg	p.L71M		NM_001004730.1	NP_001004730.1	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(12)|prostate(1)|skin(3)|stomach(1)	26						CTTTGTTGACCTGGGCTACTC	0.453000													14	274					1.5842e-08	1.83058e-08	1	1	0
HES4	57801	broad.mit.edu	37	1	934952	934952	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:934952C>T	ENST00000428771.2	-	2	522	c.324G>A	c.(322-324)gaG>gaA	p.E108E	HES4_ENST00000304952.6_Silent_p.E82E|HES4_ENST00000484667.2_Silent_p.E50E	NM_001142467.1|NM_021170.3	NP_001135939.1|NP_066993.1	Q9HCC6	HES4_HUMAN	hes family bHLH transcription factor 4	82					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			lung(2)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;9.36e-38)|OV - Ovarian serous cystadenocarcinoma(86;4.41e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00237)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TCACGGTCATCTCCAGGATGT	0.736000													7	17					0	0	1	0	0
FBXW7	55294	broad.mit.edu	37	4	153259073	153259073	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:153259073C>A	ENST00000281708.4	-	5	1971	c.742G>T	c.(742-744)Gag>Tag	p.E248*	FBXW7_ENST00000393956.3_Nonsense_Mutation_p.E72*|FBXW7_ENST00000603841.1_Nonsense_Mutation_p.E248*|RP11-461L13.2_ENST00000605147.1_RNA|FBXW7_ENST00000263981.5_Nonsense_Mutation_p.E168*|FBXW7_ENST00000296555.5_Nonsense_Mutation_p.E130*|FBXW7_ENST00000603548.1_Nonsense_Mutation_p.E248*	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	248					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.?(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGCAATTTCTCTGGTCCACTC	0.353000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								31	66					1.62565e-12	1.96081e-12	1	1	0
C1QL3	389941	broad.mit.edu	37	10	16562717	16562717	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:16562717G>C	ENST00000298943.3	-	1	1287	c.348C>G	c.(346-348)atC>atG	p.I116M		NM_001010908.1	NP_001010908.1	Q5VWW1	C1QL3_HUMAN	complement component 1, q subcomponent-like 3	116						collagen				breast(1)|endometrium(3)|kidney(1)|lung(4)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	13						TGGCGGCGCTGATGGCCCCGG	0.741000													10	28					0	0	1	0	0
KNOP1	400506	broad.mit.edu	37	16	19721887	19721887	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:19721887C>T	ENST00000219837.7	-	4	1087	c.1009G>A	c.(1009-1011)Gaa>Aaa	p.E337K	KNOP1_ENST00000568230.1_Missense_Mutation_p.E16K|AC002550.5_ENST00000565916.1_RNA	NM_001012991.2	NP_001013009.2			lysine-rich nucleolar protein 1																		TCGATCTCTTCTTGCAAGGCC	0.557000													28	96					0	0	1	0	0
CASP1	834	broad.mit.edu	37	11	104901911	104901911	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:104901911C>T	ENST00000533400.1	-	4	469	c.434G>A	c.(433-435)tGg>tAg	p.W145*	CASP1_ENST00000353247.5_Intron|CASP1_ENST00000531166.1_Intron|CASP1_ENST00000593315.1_Nonsense_Mutation_p.W124*|CASP1_ENST00000598974.1_Nonsense_Mutation_p.W145*|CASP1_ENST00000393136.4_Nonsense_Mutation_p.W124*|CASP1_ENST00000594519.1_Nonsense_Mutation_p.W52*|CASP1_ENST00000534497.1_Nonsense_Mutation_p.W52*|CASP1_ENST00000415981.2_Intron|CASP1_ENST00000528974.1_Nonsense_Mutation_p.W106*|CASP1_ENST00000527979.1_Nonsense_Mutation_p.W108*|CASP1_ENST00000526568.1_Nonsense_Mutation_p.W52*|CASP1_ENST00000525825.1_Nonsense_Mutation_p.W124*|CASP1_ENST00000446369.1_Nonsense_Mutation_p.W52*|CASP1_ENST00000436863.3_Nonsense_Mutation_p.W145*	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	145					cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	CTTTTGTTTCCATATCCTTTG	0.502000													5	40					0	0	1	0	0
SPATA21	374955	broad.mit.edu	37	1	16736388	16736388	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:16736388G>A	ENST00000335496.1	-	6	777	c.295C>T	c.(295-297)Cat>Tat	p.H99Y	SPATA21_ENST00000540400.1_Missense_Mutation_p.H76Y|SPATA21_ENST00000466212.1_5'UTR	NM_198546.1	NP_940948.1	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	99							calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		GCTCTCCGATGGGAGGCCTCC	0.662000													15	29					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109679000	109679000	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:109679000C>T	ENST00000338432.7	+	36	5055	c.4936C>T	c.(4936-4938)Ccc>Tcc	p.P1646S	ACACB_ENST00000377854.5_Missense_Mutation_p.P1576S|ACACB_ENST00000377848.3_Missense_Mutation_p.P1646S|ACACB_ENST00000543201.1_Missense_Mutation_p.P312S			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1646					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CAGTGCCGTTCCCATCCGCCT	0.562000													61	190					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183446516	183446516	+	Nonsense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:183446516C>G	ENST00000305135.5	+	7	884	c.689C>G	c.(688-690)tCa>tGa	p.S230*		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	230	YEATS.				histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AATGACCAGTCAACTCATAAG	0.378000													6	81					0	0	1	0	0
NF2	4771	broad.mit.edu	37	22	30050647	30050647	+	Splice_Site	SNP	A	A	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:30050647A>G	ENST00000338641.4	+	5	890	c.447_splice	c.e5-1	p.Y150_splice	NF2_ENST00000361166.4_Splice_Site_p.Y150_splice|NF2_ENST00000403435.1_Splice_Site_p.Y150_splice|NF2_ENST00000361452.4_Splice_Site_p.Y109_splice|NF2_ENST00000361676.4_Splice_Site_p.Y108_splice|NF2_ENST00000347330.5_Intron|NF2_ENST00000353887.4_Splice_Site_p.Y67_splice|NF2_ENST00000403999.3_Splice_Site_p.Y150_splice|NF2_ENST00000413209.2_Intron|NF2_ENST00000397789.3_Splice_Site_p.Y150_splice|NF2_ENST00000334961.7_Splice_Site_p.Y67_splice	NM_000268.3|NM_016418.5|NM_181832.2	NP_000259.1|NP_057502.2|NP_861970.1	P35240	MERL_HUMAN	neurofibromin 2 (merlin)	150	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(4)|p.Y150fs*46(1)		NS(1)|bone(2)|breast(5)|central_nervous_system(21)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(17)|large_intestine(9)|liver(1)|lung(9)|meninges(372)|ovary(2)|pituitary(1)|pleura(9)|prostate(1)|skin(7)|soft_tissue(303)|stomach(2)|thyroid(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	776						TCTTTCCAGTATGGTGACTAC	0.463000			"""D, Mis, N, F, S, O"""		"""meningioma, acoustic neuroma, renal """	"""meningioma, acoustic neuroma"""			Neurofibromatosis, type 2				51	174					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130831817	130831817	+	Nonstop_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:130831817C>A	ENST00000357462.5	-	15	3321	c.3228G>T	c.(3226-3228)taG>taT	p.*1076Y	POTEF_ENST00000409914.2_Nonstop_Mutation_p.*1076Y			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	0						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						CAGAGTCCACCTACAAGCATT	0.473000													70	153					3.00167e-28	3.83203e-28	1	1	0
PRRG4	79056	broad.mit.edu	37	11	32858356	32858356	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:32858356G>A	ENST00000257836.3	+	3	509	c.256G>A	c.(256-258)Gaa>Aaa	p.E86K		NM_024081.5	NP_076986.1	Q9BZD6	TMG4_HUMAN	proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)	86	Gla.					extracellular region|Golgi apparatus|integral to membrane	calcium ion binding	p.E86*(1)		large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	7	Breast(20;0.206)					TTTTGTGGATGAAGATAAAAC	0.358000													18	60					0	0	1	0	0
CGNL1	84952	broad.mit.edu	37	15	57730633	57730633	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:57730633C>T	ENST00000281282.5	+	2	514	c.436C>T	c.(436-438)Cag>Tag	p.Q146*		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	146	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		GCTGAACTTTCAGAGGCATCC	0.458000													16	94					0	0	1	0	0
NCSTN	23385	broad.mit.edu	37	1	160326973	160326973	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:160326973C>G	ENST00000368063.1	+	17	2157	c.1877C>G	c.(1876-1878)tCt>tGt	p.S626C	NCSTN_ENST00000535857.1_Missense_Mutation_p.S508C|NCSTN_ENST00000294785.5_Missense_Mutation_p.S646C|NCSTN_ENST00000368065.4_Missense_Mutation_p.S388C|NCSTN_ENST00000392212.4_Missense_Mutation_p.S626C			Q92542	NICA_HUMAN	nicastrin	646					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(2)	34	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACTGAATACTCTACATGGACT	0.562000													14	83					0	0	1	0	0
MTHFR	4524	broad.mit.edu	37	1	11851273	11851273	+	Missense_Mutation	SNP	C	C	T	rs45590836		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:11851273C>T	ENST00000376592.1	-	10	1871	c.1743G>A	c.(1741-1743)atG>atA	p.M581I	MTHFR_ENST00000376583.3_Missense_Mutation_p.M622I|MTHFR_ENST00000376585.1_Missense_Mutation_p.M622I|MTHFR_ENST00000376590.3_Missense_Mutation_p.M581I			P42898	MTHR_HUMAN	methylenetetrahydrofolate reductase (NAD(P)H)	581					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding			NS(4)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	CCTTCCAGAACATGAAGCTGA	0.602000													16	61					0	0	1	0	0
MS4A4A	51338	broad.mit.edu	37	11	60070147	60070147	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:60070147A>G	ENST00000355131.3	+	6	669	c.446A>G	c.(445-447)tAt>tGt	p.Y149C	MS4A4A_ENST00000337908.4_Missense_Mutation_p.Y168C|MS4A4A_ENST00000395016.3_Missense_Mutation_p.Y149C|MS4A4A_ENST00000532114.1_Intron	NM_024021.3	NP_076926.2	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member 4A	168						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(12)|prostate(1)|skin(4)	23						TGTAACTACTATGGCAACTCA	0.408000													17	63					0	0	1	0	0
PCYT1A	5130	broad.mit.edu	37	3	195984696	195984696	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:195984696G>A	ENST00000292823.2	-	4	352	c.180C>T	c.(178-180)gtC>gtT	p.V60V	PCYT1A_ENST00000431016.1_Silent_p.V60V|PCYT1A_ENST00000419333.1_Silent_p.V60V|PCYT1A_ENST00000491544.1_5'UTR	NM_005017.2	NP_005008.2	P49585	PCY1A_HUMAN	phosphate cytidylyltransferase 1, choline, alpha	60						cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity			cervix(1)|endometrium(3)|large_intestine(8)|lung(5)|ovary(1)	18	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	TAGTTACCCTGACATAGGGCT	0.368000													13	53					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140772753	140772753	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:140772753G>C	ENST00000398604.2	+	1	373	c.373G>C	c.(373-375)Gat>Cat	p.D125H	PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAAATAATTGATATTAACGA	0.428000													12	83					0	0	1	0	0
ALDH1L2	160428	broad.mit.edu	37	12	105446691	105446691	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:105446691C>T	ENST00000258494.9	-	11	1446	c.1306G>A	c.(1306-1308)Gaa>Aaa	p.E436K	ALDH1L2_ENST00000424857.2_Missense_Mutation_p.E436K	NM_001034173.3	NP_001029345.2	Q3SY69	AL1L2_HUMAN	aldehyde dehydrogenase 1 family, member L2	436					10-formyltetrahydrofolate catabolic process|biosynthetic process	mitochondrion	acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity|phosphopantetheine binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|prostate(2)|skin(3)|stomach(2)	35						ACCATGATTTCATTGACCTCC	0.363000											OREG0022073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	51					0	0	1	0	0
FBXO10	26267	broad.mit.edu	37	9	37516041	37516041	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:37516041G>A	ENST00000432825.2	-	10	2604	c.2556C>T	c.(2554-2556)atC>atT	p.I852I	RP11-613M10.8_ENST00000544475.1_5'UTR|FBXO10_ENST00000541829.1_Silent_p.I377I	NM_012166.2	NP_036298.2	Q9UK96	FBX10_HUMAN	F-box protein 10	852						ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(1)|endometrium(5)|large_intestine(11)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	34				GBM - Glioblastoma multiforme(29;0.0107)		CCCGCACGGCGATGCCGTAGG	0.552000													22	43					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46860001	46860001	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:46860001G>A	ENST00000262738.3	-	2	3785	c.3786C>T	c.(3784-3786)ttC>ttT	p.F1262F	CELSR1_ENST00000395964.1_Silent_p.F1262F	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	1262					central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		GCAGCGCCGAGAAGGTCACGT	0.632000													14	46					0	0	1	0	0
ZPBP2	124626	broad.mit.edu	37	17	38032984	38032984	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:38032984G>A	ENST00000377940.3	+	7	1012	c.873G>A	c.(871-873)caG>caA	p.Q291Q	ZPBP2_ENST00000584588.1_Silent_p.Q240Q|ZPBP2_ENST00000348931.4_Silent_p.Q313Q	NM_198844.2	NP_942141.2	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2	313					binding of sperm to zona pellucida	extracellular region				kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			TAACTTGTCAGACCTGCGTTT	0.378000													17	229					0	0	1	0	0
ELP4	26610	broad.mit.edu	37	11	31653772	31653772	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:31653772G>T	ENST00000395934.2	+	7	754	c.747G>T	c.(745-747)caG>caT	p.Q249H	ELP4_ENST00000379163.5_Missense_Mutation_p.Q250H|ELP4_ENST00000350638.5_Missense_Mutation_p.Q249H			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	249					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					AGAAAAAACAGAGAAACATTT	0.333000													8	57					0.000157383	0.000166102	1	1	0
SPHKAP	80309	broad.mit.edu	37	2	228881246	228881246	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:228881246C>T	ENST00000392056.3	-	7	4370	c.4324G>A	c.(4324-4326)Gaa>Aaa	p.E1442K	SPHKAP_ENST00000344657.5_Missense_Mutation_p.E1442K	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1442						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GGTTCAGGTTCCCCAGCACAG	0.498000													9	93					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430751	37430751	+	Nonsense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:37430751T>A	ENST00000374660.1	+	7	857	c.758T>A	c.(757-759)tTg>tAg	p.L253*	ANKRD30A_ENST00000602533.1_Nonsense_Mutation_p.L253*|ANKRD30A_ENST00000361713.1_Nonsense_Mutation_p.L253*			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	309						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GCTGCACCCTTGGTGGAAAGA	0.498000													18	41					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063871	9063871	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:9063871C>T	ENST00000397910.4	-	3	23778	c.23575G>A	c.(23575-23577)Gct>Act	p.A7859T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7861	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCAGTAGTAGCACCAGTGGGC	0.557000													19	74					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32832633	32832633	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:32832633G>A	ENST00000421745.2	+	72	14316	c.14182G>A	c.(14182-14184)Gat>Aat	p.D4728N		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4728					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TCGAGAATATGATGGAAACAT	0.403000													19	99					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1219336	1219336	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:1219336G>T	ENST00000326873.7	+	3	1561	c.388G>T	c.(388-390)Gag>Tag	p.E130*	STK11_ENST00000585748.1_3'UTR	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	130	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		TATGGTGATGGAGTACTGCGT	0.667000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			3	5					0.004672	0.0047814	1	1	0
POLG	5428	broad.mit.edu	37	15	89864473	89864473	+	Missense_Mutation	SNP	C	C	T	rs121918047		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:89864473C>T	ENST00000268124.5	-	17	2950	c.2617G>A	c.(2617-2619)Gag>Aag	p.E873K	POLG_ENST00000442287.2_Missense_Mutation_p.E873K	NM_001126131.1|NM_002693.2	NP_001119603.1|NP_002684.1	P54098	DPOG1_HUMAN	polymerase (DNA directed), gamma	873					base-excision repair, gap-filling|cell death|DNA-dependent DNA replication	mitochondrial nucleoid	DNA binding|DNA-directed DNA polymerase activity|protease binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(3)|urinary_tract(2)	33	Lung NSC(78;0.0472)|all_lung(78;0.089)		STAD - Stomach adenocarcinoma(125;0.165)			GCTTTCAACTCACTGCCTACT	0.562000								DNA polymerases (catalytic subunits)					16	60					0	0	1	0	0
DDX59	83479	broad.mit.edu	37	1	200635800	200635800	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:200635800C>G	ENST00000447706.2	-	2	220	c.69G>C	c.(67-69)aaG>aaC	p.K23N	DDX59_ENST00000331314.6_Missense_Mutation_p.K23N|DDX59_ENST00000367348.3_Missense_Mutation_p.K23N			Q5T1V6	DDX59_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 59	23						intracellular	ATP binding|ATP-dependent helicase activity|metal ion binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|liver(1)|lung(9)|ovary(3)	21						GTTTAATTATCTTAGCCACAC	0.383000													11	231					0	0	1	0	0
TECPR1	25851	broad.mit.edu	37	7	97873911	97873911	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:97873911C>G	ENST00000447648.2	-	5	802	c.503G>C	c.(502-504)aGa>aCa	p.R168T	TECPR1_ENST00000379795.3_Missense_Mutation_p.R168T|TECPR1_ENST00000542604.1_Missense_Mutation_p.R89T			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	168						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GGACTTGTATCTCCTGTACCG	0.572000													22	57					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102040645	102040645	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:102040645C>T	ENST00000549145.1	+	12	1134	c.1034C>T	c.(1033-1035)tCc>tTc	p.S345F	MYBPC1_ENST00000547405.1_Missense_Mutation_p.S306F|MYBPC1_ENST00000553190.1_Missense_Mutation_p.S332F|MYBPC1_ENST00000441232.1_Missense_Mutation_p.S332F|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000360610.2_Missense_Mutation_p.S332F|MYBPC1_ENST00000392934.3_Missense_Mutation_p.S319F|MYBPC1_ENST00000452455.2_Missense_Mutation_p.S332F|RP11-755O11.2_ENST00000552081.1_RNA|MYBPC1_ENST00000550270.1_Missense_Mutation_p.S332F|RP11-755O11.2_ENST00000547027.1_RNA|MYBPC1_ENST00000547509.1_Missense_Mutation_p.S318F|MYBPC1_ENST00000541119.1_Missense_Mutation_p.S320F|MYBPC1_ENST00000361466.2_Missense_Mutation_p.S357F|MYBPC1_ENST00000536007.1_Missense_Mutation_p.S313F|MYBPC1_ENST00000545503.2_Missense_Mutation_p.S332F|MYBPC1_ENST00000361685.2_Missense_Mutation_p.S357F|MYBPC1_ENST00000551300.1_Missense_Mutation_p.S233F			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	332	Ig-like C2-type 3.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						GAGAAATGTTCCACTGAGCTC	0.403000													5	82					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	64984838	64984838	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:64984838C>T	ENST00000394156.3	-	12	2179	c.1726G>A	c.(1726-1728)Gat>Aat	p.D576N	CDH11_ENST00000268603.4_Missense_Mutation_p.D576N|CDH11_ENST00000566827.1_Missense_Mutation_p.D450N			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	576	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		ATGCCGCCATCGCTGATCACT	0.602000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			9	31					0	0	1	0	0
CREB5	9586	broad.mit.edu	37	7	28610085	28610085	+	Nonsense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:28610085C>T	ENST00000357727.2	+	5	784	c.394C>T	c.(394-396)Cag>Tag	p.Q132*	CREB5_ENST00000396300.2_Nonsense_Mutation_p.Q125*|CREB5_ENST00000409603.1_Nonsense_Mutation_p.Q99*|CREB5_ENST00000396299.2_Nonsense_Mutation_p.Q99*	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	132					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						CGTTGTGATTCAGCAAGCCAT	0.602000													26	69					0	0	1	0	0
CNBD2	140894	broad.mit.edu	37	20	34572668	34572668	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:34572668G>A	ENST00000373973.3	+	6	857	c.684G>A	c.(682-684)caG>caA	p.Q228Q	CNBD2_ENST00000349339.1_Silent_p.Q228Q|CNBD2_ENST00000538900.1_Silent_p.Q228Q					cyclic nucleotide binding domain containing 2																		AGGAAGTTCAGAAGGATGCTC	0.448000													55	174					0	0	1	0	0
FEZ2	9637	broad.mit.edu	37	2	36810584	36810584	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:36810584G>A	ENST00000379245.4	-	3	452	c.404C>T	c.(403-405)tCa>tTa	p.S135L	FEZ2_ENST00000305852.7_5'UTR|FEZ2_ENST00000405912.3_Missense_Mutation_p.S135L	NM_001042548.1	NP_001036013.1	Q9UHY8	FEZ2_HUMAN	fasciculation and elongation protein zeta 2 (zygin II)	135					axon guidance|signal transduction		protein binding			breast(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	7		all_hematologic(82;0.21)				TTCATCATCTGATGTATCAAA	0.403000													14	87					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145883539	145883539	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:145883539C>G	ENST00000296702.5	+	18	2738	c.2700C>G	c.(2698-2700)atC>atG	p.I900M	TCERG1_ENST00000509787.1_3'UTR|TCERG1_ENST00000394421.2_Missense_Mutation_p.I879M	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	900	FF 4.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGAAGCTATCCAGAATTTCA	0.373000													17	53					0	0	1	0	0
PCDHGA10	56106	broad.mit.edu	37	5	140794397	140794397	+	Nonsense_Mutation	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:140794397T>A	ENST00000398610.2	+	1	1655	c.1655T>A	c.(1654-1656)tTg>tAg	p.L552*	PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018913.2|NM_032090.1	NP_061736.1|NP_114479.1														breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	43			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGTGTCGTTGAGCCTGTTT	0.602000													60	208					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86260571	86260571	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:86260571C>T	ENST00000394518.2	+	21	5881	c.5786C>T	c.(5785-5787)tCa>tTa	p.S1929L	AKAP13_ENST00000394510.2_Missense_Mutation_p.S174L|AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000361243.2_Missense_Mutation_p.S1933L	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1929	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						CTGTCTCATTCAACAGACTCA	0.368000													10	49					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87645071	87645071	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:87645071C>T	ENST00000320005.5	-	11	1276	c.1229G>A	c.(1228-1230)gGc>gAc	p.G410D		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	410					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						TTCTGGAAGGCCACCAATGGT	0.328000													12	55					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24808843	24808843	+	Missense_Mutation	SNP	A	A	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:24808843A>C	ENST00000395799.3	+	10	3723	c.3594A>C	c.(3592-3594)gaA>gaC	p.E1198D	TNRC6A_ENST00000315183.7_Missense_Mutation_p.E1198D	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1198	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		AACAAGAAGAAGCGTGGATAA	0.363000													14	49					0	0	1	0	0
USP42	84132	broad.mit.edu	37	7	6196425	6196425	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:6196425G>A	ENST00000306177.5	+	16	3840	c.3682G>A	c.(3682-3684)Gct>Act	p.A1228T		NM_032172.2	NP_115548.1	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	1228	Lys-rich.				cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(2)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	35		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		GTGCTCTGACGCTGACCTCCA	0.453000													7	14					0	0	1	0	0
CYYR1	116159	broad.mit.edu	37	21	27945306	27945306	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr21:27945306G>A	ENST00000435845.2	-	1	297	c.278C>T	c.(277-279)cCg>cTg	p.P93L	CYYR1_ENST00000400043.3_5'UTR|CYYR1_ENST00000299340.4_5'UTR			Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	134						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						GCCCGGAACCGGAGGGAATGG	0.652000													10	48					0	0	1	0	0
FADD	8772	broad.mit.edu	37	11	70049625	70049625	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:70049625G>A	ENST00000301838.4	+	1	357	c.60G>A	c.(58-60)ctG>ctA	p.L20L		NM_003824.3	NP_003815.1	Q13158	FADD_HUMAN	Fas (TNFRSF6)-associated via death domain	20	DED.				activation of caspase activity|activation of pro-apoptotic gene products|cellular response to mechanical stimulus|defense response to virus|induction of apoptosis via death domain receptors|innate immune response|interspecies interaction between organisms|necrotic cell death|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|signal transduction	cytosol	death receptor binding|identical protein binding			endometrium(1)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(2)	9	Esophageal squamous(2;1.19e-45)		LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			GCAGCGAGCTGACCGAGCTCA	0.687000													4	10					0	0	1	0	0
YWHAH	7533	broad.mit.edu	37	22	32352124	32352124	+	Splice_Site	SNP	A	A	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr22:32352124A>C	ENST00000397492.1	+	3	414		c.e3-1		YWHAH_ENST00000248975.5_Splice_Site|YWHAH_ENST00000471374.1_Splice_Site			Q04917	1433F_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide						glucocorticoid catabolic process|glucocorticoid receptor signaling pathway|intracellular protein transport|negative regulation of dendrite morphogenesis|positive regulation of transcription, DNA-dependent|regulation of synaptic plasticity	cytoplasm	enzyme binding|glucocorticoid receptor binding|insulin-like growth factor receptor binding|protein domain specific binding			breast(1)|central_nervous_system(1)|large_intestine(1)|upper_aerodigestive_tract(1)	4						GGGGTTTTGCAGGTGACAGAG	0.433000													16	68					0	0	1	0	0
ZNF232	7775	broad.mit.edu	37	17	5009292	5009292	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:5009292C>T	ENST00000250076.3	-	5	1816	c.1162G>A	c.(1162-1164)Gag>Aag	p.E388K	ZNF232_ENST00000575898.1_Missense_Mutation_p.E379K|ZNF232_ENST00000416429.2_3'UTR	NM_014519.2	NP_055334.2	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	361					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2)	11						TCATTACACTCATAGGGCTTC	0.443000													16	52					0	0	1	0	0
ASUN	55726	broad.mit.edu	37	12	27081681	27081681	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:27081681C>A	ENST00000261191.7	-	4	994	c.458G>T	c.(457-459)cGt>cTt	p.R153L	ASUN_ENST00000539625.1_Missense_Mutation_p.R52L	NM_018164.2	NP_060634.2	Q9NVM9	M89BB_HUMAN	asunder spermatogenesis regulator	153					cell division|mitosis|regulation of mitotic cell cycle		protein binding										ATTTCCAACACGTTCTGCATT	0.393000													20	94					1.2644e-06	1.38972e-06	1	1	0
GLTPD2	388323	broad.mit.edu	37	17	4692920	4692920	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:4692920G>A	ENST00000331264.7	+	3	339	c.286G>A	c.(286-288)Gaa>Aaa	p.E96K		NM_001014985.2	NP_001014985.2			glycolipid transfer protein domain containing 2											endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)	4						TCTGAAACCCGAAGGGGATGT	0.706000													4	51					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140475572	140475572	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:140475572G>A	ENST00000194155.4	+	1	1346	c.1198G>A	c.(1198-1200)Gag>Aag	p.E400K		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		400	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCTTCTGTTGAGAACTTTTA	0.502000													14	78					0	0	1	0	0
NCAM2	4685	broad.mit.edu	37	21	22881290	22881290	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr21:22881290G>A	ENST00000400546.1	+	16	2445	c.2196G>A	c.(2194-2196)ctG>ctA	p.L732L	NCAM2_ENST00000284894.7_Silent_p.L590L	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	732					neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		GTGGGTTGCTGATGTGCATCA	0.473000													24	67					0	0	1	0	0
FAR1	84188	broad.mit.edu	37	11	13729507	13729507	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:13729507G>T	ENST00000354817.3	+	4	570	c.426G>T	c.(424-426)atG>atT	p.M142I		NM_032228.5	NP_115604.1	Q8WVX9	FACR1_HUMAN	fatty acyl CoA reductase 1	142					ether lipid biosynthetic process	integral to membrane|peroxisomal matrix|peroxisomal membrane	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13						CACAACAAATGAAGAATCTGG	0.393000													6	60					0.0293803	0.0297406	1	1	0
ROBO3	64221	broad.mit.edu	37	11	124735554	124735554	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:124735554C>A	ENST00000397801.1	+	1	273	c.81C>A	c.(79-81)agC>agA	p.S27R		NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	27					axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CCAACTCCAGCGAGCTGCTCT	0.632000											OREG0021466	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	17					7.48243e-07	8.27298e-07	1	1	0
ZNF733P	643955	broad.mit.edu	37	7	62752285	62752285	+	RNA	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:62752285G>T	ENST00000331425.6	-	0	1150					NR_003952.1																						AGTAAGTGCTGAGGAGCGCCT	0.438000													14	53					6.94344e-10	8.12438e-10	1	1	0
ACVR1B	91	broad.mit.edu	37	12	52385768	52385768	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:52385768G>C	ENST00000257963.4	+	8	1460	c.1383G>C	c.(1381-1383)caG>caC	p.Q461H	ACVR1B_ENST00000541224.1_Missense_Mutation_p.Q502H|ACVR1B_ENST00000426655.2_Missense_Mutation_p.Q461H|ACVR1B_ENST00000542485.1_Missense_Mutation_p.Q409H|ACVR1B_ENST00000563121.1_3'UTR	NM_004302.4|NM_020328.3	NP_004293.1|NP_064733.3	P36896	ACV1B_HUMAN	activin A receptor, type IB	461	Protein kinase.				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			breast(5)|endometrium(4)|kidney(5)|large_intestine(12)|lung(10)|ovary(1)|pancreas(6)|prostate(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	ACTGGTGGCAGAGTTATGAGG	0.512000													23	93					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93956608	93956608	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:93956608C>A	ENST00000369303.4	-	15	2812	c.2628G>T	c.(2626-2628)gaG>gaT	p.E876D		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	876	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TTTCAGCACGCTCCTTTTGCC	0.423000													15	66					3.27435e-08	3.72564e-08	1	1	0
FBXO38	81545	broad.mit.edu	37	5	147781565	147781565	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:147781565C>G	ENST00000340253.5	+	4	451	c.283C>G	c.(283-285)Cta>Gta	p.L95V	FBXO38_ENST00000394370.3_Missense_Mutation_p.L95V|FBXO38_ENST00000296701.6_Missense_Mutation_p.L95V|FBXO38_ENST00000509699.2_3'UTR|FBXO38_ENST00000513826.1_Missense_Mutation_p.L95V			Q6PIJ6	FBX38_HUMAN	F-box protein 38	95	Interaction with KLF7 (By similarity).					cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCAGTTTTCTAACACTATT	0.413000													25	92					0	0	1	0	0
ZNF628	89887	broad.mit.edu	37	19	55993031	55993031	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:55993031C>G	ENST00000391718.2	+	3	1024	c.459C>G	c.(457-459)ttC>ttG	p.F153L	ZNF628_ENST00000598519.1_Missense_Mutation_p.F157L			Q5EBL2	ZN628_HUMAN	zinc finger protein 628	153						nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|lung(2)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		CCAAGGCCTTCAAGAACTCGT	0.662000													5	19					0	0	1	0	0
CLRN1	7401	broad.mit.edu	37	3	150659411	150659411	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:150659411G>T	ENST00000327047.1	-	2	681	c.391C>A	c.(391-393)Ctg>Atg	p.L131M	CLRN1_ENST00000295911.2_Missense_Mutation_p.L55M|RP11-166N6.3_ENST00000569170.1_Silent_p.L40L|CLRN1-AS1_ENST00000476886.1_RNA|CLRN1_ENST00000328863.4_Missense_Mutation_p.L131M|RP11-166N6.2_ENST00000469268.1_RNA	NM_174878.2	NP_777367.1	P58418	CLRN1_HUMAN	clarin 1	131					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	14			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GGACCATGCAGAGTTTCAAAA	0.413000													10	49					0.00829132	0.00846216	1	1	0
CCSER1	401145	broad.mit.edu	37	4	91230708	91230708	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:91230708C>T	ENST00000509176.1	+	2	1561	c.1273C>T	c.(1273-1275)Cat>Tat	p.H425Y	CCSER1_ENST00000333691.8_Missense_Mutation_p.H425Y|CCSER1_ENST00000432775.2_Missense_Mutation_p.H425Y	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		TTCTGGTGATCATCATATTTT	0.303000													12	80					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14748416	14748416	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:14748416G>T	ENST00000380881.4	-	32	6597	c.5782C>A	c.(5782-5784)Cgt>Agt	p.R1928S	FREM1_ENST00000422223.2_Missense_Mutation_p.R1927S|FREM1_ENST00000380880.3_Missense_Mutation_p.R1927S|FREM1_ENST00000380894.1_Missense_Mutation_p.R463S			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1927					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		CCATTCCCACGGGTCCTAAGC	0.433000													15	33					3.27435e-08	3.72564e-08	1	1	0
PPFIA1	8500	broad.mit.edu	37	11	70176314	70176314	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:70176314C>T	ENST00000253925.7	+	8	1181	c.966C>T	c.(964-966)atC>atT	p.I322I	AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Silent_p.I322I	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	322					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			AAGAGAGAATCACTACTCTTG	0.373000													21	83					0	0	1	0	0
IFNA17	3451	broad.mit.edu	37	9	21227646	21227646	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:21227646G>C	ENST00000413767.2	-	1	575	c.527C>G	c.(526-528)tCt>tGt	p.S176C		NM_021268.2	NP_067091.1	P01571	IFN17_HUMAN	interferon, alpha 17	176					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(1)|endometrium(2)|lung(4)|ovary(1)|skin(1)	9				Lung(24;2.13e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TGTTGAAAAAGAGAGAGATCT	0.373000													27	378					0	0	1	0	0
NLRP4	147945	broad.mit.edu	37	19	56369554	56369554	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:56369554G>A	ENST00000301295.6	+	3	1217	c.795G>A	c.(793-795)ctG>ctA	p.L265L	NLRP4_ENST00000587891.1_Silent_p.L190L|NLRP4_ENST00000346986.5_Silent_p.L265L	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	265	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		GCAGTTTGCTGAGGAAGAAGA	0.577000													10	92					0	0	1	0	0
GUF1	60558	broad.mit.edu	37	4	44682781	44682781	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:44682781C>T	ENST00000281543.5	+	3	542	c.348C>T	c.(346-348)atC>atT	p.I116I	GUF1_ENST00000506793.1_3'UTR	NM_021927.2	NP_068746.2	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog (S. cerevisiae)	116					translation	mitochondrial inner membrane	GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19						aaagaggaatcactgTTAAAG	0.318000													15	42					0	0	1	0	0
NR1H2	7376	broad.mit.edu	37	19	50881426	50881426	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:50881426G>T	ENST00000253727.5	+	5	437	c.202G>T	c.(202-204)Gaa>Taa	p.E68*	NR1H2_ENST00000542413.1_5'UTR|NR1H2_ENST00000411902.2_Intron|NR1H2_ENST00000593926.1_Nonsense_Mutation_p.E68*|NR1H2_ENST00000598168.1_Nonsense_Mutation_p.E68*|NR1H2_ENST00000599105.1_Nonsense_Mutation_p.E68*	NM_007121.5	NP_009052.3	P55055	NR1H2_HUMAN	nuclear receptor subfamily 1, group H, member 2	68					negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of pinocytosis|negative regulation of transcription, DNA-dependent|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(2)	8		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00757)|GBM - Glioblastoma multiforme(134;0.0186)		TCCCGAAGAGGAACCAGAGCG	0.597000													37	176					1.06647e-15	1.33175e-15	1	1	0
PJA2	9867	broad.mit.edu	37	5	108714857	108714857	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:108714857G>C	ENST00000361189.2	-	4	570	c.331C>G	c.(331-333)Caa>Gaa	p.Q111E	PJA2_ENST00000361557.3_Missense_Mutation_p.Q111E	NM_014819.4	NP_055634.3	O43164	PJA2_HUMAN	praja ring finger 2, E3 ubiquitin protein ligase	111					long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		TCAGTGGTTTGATTCAATGCT	0.413000													29	75					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127432	152127432	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:152127432C>A	ENST00000316073.3	-	3	2207	c.2143G>T	c.(2143-2145)Gat>Tat	p.D715Y		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	715	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CTGTGTCTATCCCAAGTTTGA	0.562000													58	347					8.99859e-20	1.14095e-19	1	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117375335	117375335	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:117375335T>C	ENST00000160373.3	-	15	3767	c.3676A>G	c.(3676-3678)Act>Gct	p.T1226A		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1226										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TTTTGGAAAGTGCAGGGGCTT	0.383000													6	84					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1220706	1220706	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:1220706G>T	ENST00000326873.7	+	5	1897	c.724G>T	c.(724-726)Ggg>Tgg	p.G242W		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	242	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)|p.G242W(1)|p.G242R(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGTCGGCTGGGGTCACCCT	0.706000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			9	35					0.000673444	0.00070178	1	1	0
FXR1	8087	broad.mit.edu	37	3	180630498	180630498	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:180630498C>T	ENST00000357559.4	+	1	409	c.25C>T	c.(25-27)Cgc>Tgc	p.R9C	FXR1_ENST00000491062.1_Missense_Mutation_p.R9C|FXR1_ENST00000468861.1_5'UTR|FXR1_ENST00000491674.1_Missense_Mutation_p.R9C|FXR1_ENST00000305586.7_5'UTR|FXR1_ENST00000445140.2_Missense_Mutation_p.R9C	NM_001013438.2|NM_005087.3	NP_001013456.1|NP_005078.2	P51114	FXR1_HUMAN	fragile X mental retardation, autosomal homolog 1	9					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome				breast(3)|endometrium(4)|large_intestine(5)|lung(12)|skin(2)	26	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			GGTGGAGGTTCGCGGCTCTAA	0.592000											OREG0015934	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	153					0	0	1	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90503533	90503533	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:90503533C>A	ENST00000325643.5	+	4	4197	c.4131C>A	c.(4129-4131)tgC>tgA	p.C1377*		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CTCTGGCCTGCAGCCCTAAAG	0.607000													4	46					0.150653	0.151264	1	1	0
HTRA4	203100	broad.mit.edu	37	8	38840066	38840066	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:38840066C>T	ENST00000302495.4	+	7	1264	c.1164C>T	c.(1162-1164)ctC>ctT	p.L388L		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	388	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			TGCTGTCCCTCACTGTGCCGT	0.423000													12	88					0	0	1	0	0
ETFB	2109	broad.mit.edu	37	19	51869556	51869556	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:51869556C>A	ENST00000309244.4	-	1	116	c.25G>T	c.(25-27)Gct>Tct	p.A9S	CTD-2616J11.11_ENST00000600067.1_Intron	NM_001985.2	NP_001976.1	P38117	ETFB_HUMAN	electron-transfer-flavoprotein, beta polypeptide	9					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity			kidney(2)|large_intestine(1)|lung(3)	6		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)		CTCTTGACAGCTACGAGCACG	0.692000													7	19					1.06961e-07	1.2023e-07	1	1	0
CCT6A	908	broad.mit.edu	37	7	56127301	56127301	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:56127301G>T	ENST00000275603.4	+	9	1252	c.1033G>T	c.(1033-1035)Gga>Tga	p.G345*	CCT6A_ENST00000335503.3_Nonsense_Mutation_p.G300*|CCT6A_ENST00000540286.1_Nonsense_Mutation_p.G314*	NM_001762.3	NP_001753.1	P40227	TCPZ_HUMAN	chaperonin containing TCP1, subunit 6A (zeta 1)	345					'de novo' posttranslational protein folding	cytosol	ATP binding|unfolded protein binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)	15	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TGACTGCTTGGGACATGCAGG	0.383000													15	58					6.31663e-08	7.15435e-08	1	1	0
ZNF451	26036	broad.mit.edu	37	6	57018737	57018737	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:57018737G>C	ENST00000370706.4	+	13	3206	c.2962G>C	c.(2962-2964)Gag>Cag	p.E988Q	ZNF451_ENST00000357489.3_Missense_Mutation_p.E940Q|RP11-203B9.4_ENST00000586466.1_RNA|RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000589549.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000589263.1_RNA|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|ZNF451_ENST00000491832.2_Missense_Mutation_p.E988Q	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	988					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TCTGGAGCTAGAGAATCAATT	0.423000													18	135					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77369759	77369759	+	Missense_Mutation	SNP	G	G	T	rs146649352		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:77369759G>T	ENST00000282849.5	-	12	2171	c.1753C>A	c.(1753-1755)Ccc>Acc	p.P585T		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	585					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						ATGGGCCGGGGCCCGAGCTCC	0.582000													63	132					6.25564e-26	7.97246e-26	1	1	0
CD8A	925	broad.mit.edu	37	2	87017610	87017610	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:87017610C>T	ENST00000409511.2	-	5	1274	c.244G>A	c.(244-246)Gag>Aag	p.E82K	CD8A_ENST00000456996.2_Missense_Mutation_p.E82K|CD8A_ENST00000283635.3_Missense_Mutation_p.E82K|CD8A_ENST00000409781.1_Missense_Mutation_p.E82K|CD8A_ENST00000352580.3_Missense_Mutation_p.E82K|CD8A_ENST00000538832.1_Missense_Mutation_p.E123K	NM_001145873.1	NP_001139345.1	P01732	CD8A_HUMAN	CD8a molecule	82	Ig-like V-type.				antigen processing and presentation|regulation of immune response|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	8						TCCAGCCCCTCGGCCGCCTTG	0.657000													21	130					0	0	1	0	0
KDM4D	55693	broad.mit.edu	37	11	94730600	94730600	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:94730600C>T	ENST00000335080.5	+	3	896	c.64C>T	c.(64-66)Cat>Tat	p.H22Y	KDM4D_ENST00000536741.1_Missense_Mutation_p.H22Y	NM_018039.2	NP_060509.2	Q6B0I6	KDM4D_HUMAN	lysine (K)-specific demethylase 4D	22	JmjN.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						AATGATATTTCATCCAACCAA	0.353000													8	103					0	0	1	0	0
SPRYD4	283377	broad.mit.edu	37	12	56863238	56863238	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:56863238G>A	ENST00000338146.5	+	2	576	c.501G>A	c.(499-501)gtG>gtA	p.V167V		NM_207344.3	NP_997227.1	Q8WW59	SPRY4_HUMAN	SPRY domain containing 4	167	B30.2/SPRY.					nucleus				kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)	7						TGGTGGATGTGAGCCAGGTCT	0.592000													15	51					0	0	1	0	0
CDK15	65061	broad.mit.edu	37	2	202672348	202672348	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:202672348G>A	ENST00000450471.2	+	2	341	c.255G>A	c.(253-255)ctG>ctA	p.L85L	CDK15_ENST00000260967.2_Silent_p.L34L|CDK15_ENST00000488419.1_3'UTR|CDK15_ENST00000374598.4_Silent_p.L85L|CDK15_ENST00000410091.3_Silent_p.L34L|CDK15_ENST00000434439.1_Silent_p.L85L	NM_001261435.1	NP_001248364.1	Q96Q40	CDK15_HUMAN	cyclin-dependent kinase 15	85							ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(3)|endometrium(2)|kidney(5)|large_intestine(1)|lung(14)|ovary(1)	26					Adenosine triphosphate(DB00171)	AAGAGGATCTGAGGCAGGGTT	0.498000													10	89					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128393857	128393857	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:128393857C>T	ENST00000389524.4	+	44	6059	c.6006C>T	c.(6004-6006)atC>atT	p.I2002I	MYO7B_ENST00000409816.2_Silent_p.I2001I|MYO7B_ENST00000409090.1_Silent_p.I854I|MYO7B_ENST00000428314.1_Silent_p.I2001I			Q6PIF6	MYO7B_HUMAN	myosin VIIB	2001	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGAAGTGGATCTGCCGGTGGC	0.612000													6	67					0	0	1	0	0
NOS3	4846	broad.mit.edu	37	7	150711226	150711226	+	Missense_Mutation	SNP	A	A	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:150711226A>T	ENST00000297494.3	+	27	3938	c.3581A>T	c.(3580-3582)gAc>gTc	p.D1194V	ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000444312.1_3'UTR|NOS3_ENST00000461406.1_Missense_Mutation_p.D988V|NOS3_ENST00000477227.1_3'UTR|ATG9B_ENST00000377974.2_3'UTR|ATG9B_ENST00000605938.1_3'UTR	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	1194				D -> E (in Ref. 6; CAA53950).	anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	TGGGCGTTCGACCCTCCCGGC	0.677000													13	22					0	0	1	0	0
GSDMA	284110	broad.mit.edu	37	17	38127854	38127854	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:38127854C>T	ENST00000301659.4	+	5	754	c.636C>T	c.(634-636)gtC>gtT	p.V212V		NM_178171.4	NP_835465.2	Q96QA5	GSDMA_HUMAN	gasdermin A	212					apoptosis|induction of apoptosis	perinuclear region of cytoplasm				NS(1)|endometrium(2)|large_intestine(3)|lung(1)	7						AGCTGATGGTCAAAGGCAAAG	0.522000													6	30					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103834	53103834	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:53103834G>C	ENST00000408890.4	+	1	486	c.470G>C	c.(469-471)aGa>aCa	p.R157T		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	157										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CCTGGACAGAGAgcccgcccc	0.726000													6	28					0	0	1	0	0
KRT6C	286887	broad.mit.edu	37	12	52863629	52863629	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:52863629C>A	ENST00000252250.6	-	7	1296	c.1249G>T	c.(1249-1251)Gag>Tag	p.E417*		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	417	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		AGTGCCATCTCCCCACGCTGC	0.597000													10	63					1.3612e-06	1.49391e-06	1	1	0
KIAA0319	9856	broad.mit.edu	37	6	24596317	24596317	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:24596317G>A	ENST00000535378.1	-	4	1200	c.558C>T	c.(556-558)ttC>ttT	p.F186F	KIAA0319_ENST00000378214.3_Silent_p.F195F|KIAA0319_ENST00000430948.2_Silent_p.F150F|KIAA0319_ENST00000537886.1_Silent_p.F195F|KIAA0319_ENST00000543707.1_Silent_p.F195F	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	195					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						CAGAGGAGTTGAAGGCCCCCT	0.627000													7	63					0	0	1	0	0
CEP192	55125	broad.mit.edu	37	18	13099553	13099553	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr18:13099553C>G	ENST00000506447.1	+	37	6716	c.6636C>G	c.(6634-6636)atC>atG	p.I2212M	CEP192_ENST00000325971.8_Missense_Mutation_p.I1616M|CEP192_ENST00000540847.2_3'UTR|CEP192_ENST00000430049.2_Missense_Mutation_p.I1737M	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	1807										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GTGGTTTGATCTATATACACT	0.323000													24	114					0	0	1	0	0
TRIM13	10206	broad.mit.edu	37	13	50587237	50587237	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr13:50587237G>C	ENST00000378182.3	+	2	1899	c.1161G>C	c.(1159-1161)aaG>aaC	p.K387N	TRIM13_ENST00000420995.2_Missense_Mutation_p.K387N|TRIM13_ENST00000356017.4_Missense_Mutation_p.K390N|TRIM13_ENST00000457662.2_Missense_Mutation_p.K387N|TRIM13_ENST00000478111.1_Intron|TRIM13_ENST00000298772.5_Missense_Mutation_p.K390N	NM_001007278.1|NM_005798.3|NM_052811.2|NM_213590.1	NP_001007279.1|NP_005789.2|NP_434698.1|NP_998755.1	O60858	TRI13_HUMAN	tripartite motif containing 13	387					anatomical structure morphogenesis|ER-associated protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination	cytoplasm|endoplasmic reticulum membrane|integral to membrane	protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.K387N(1)		large_intestine(5)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	10		Acute lymphoblastic leukemia(7;3.41e-06)|Lung NSC(96;3.08e-05)|Breast(56;9.7e-05)|Prostate(109;0.00174)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;1.53e-10)|COAD - Colon adenocarcinoma(199;0.205)		AAAGATTCAAGAATTTTACTT	0.318000													35	95					0	0	1	0	0
HIST1H2AK	8330	broad.mit.edu	37	6	27806062	27806062	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:27806062G>A	ENST00000330180.2	-	1	55	c.56C>T	c.(55-57)tCt>tTt	p.S19F		NM_003510.2	NP_003501.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	19					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(2)|endometrium(2)|kidney(1)|lung(3)|upper_aerodigestive_tract(2)	10						CGCCCTTGAAGAACGGGTCTT	0.602000													14	57					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71317674	71317674	+	Nonsense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:71317674G>C	ENST00000338099.5	-	3	2486	c.2150C>G	c.(2149-2151)tCa>tGa	p.S717*	FTSJD1_ENST00000434935.2_Nonsense_Mutation_p.S717*			Q8IYT2	FTSJ1_HUMAN		717						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CTGCTGGGGTGAGTCAGAGTT	0.453000													15	44					0	0	1	0	0
PRPSAP2	5636	broad.mit.edu	37	17	18775902	18775902	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:18775902G>C	ENST00000268835.2	+	5	462	c.179G>C	c.(178-180)aGa>aCa	p.R60T	PRPSAP2_ENST00000419071.2_Intron|PRPSAP2_ENST00000536323.1_5'UTR|PRPSAP2_ENST00000542013.1_Missense_Mutation_p.R60T	NM_002767.3	NP_002758.1	O60256	KPRB_HUMAN	phosphoribosyl pyrophosphate synthetase-associated protein 2	60					nucleotide biosynthetic process		enzyme inhibitor activity|magnesium ion binding|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11						CCAGAAACAAGAGTACAAATT	0.348000													50	208					0	0	1	0	0
FARSB	10056	broad.mit.edu	37	2	223488993	223488993	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:223488993G>A	ENST00000281828.6	-	12	1431	c.1168C>T	c.(1168-1170)Caa>Taa	p.Q390*	FARSB_ENST00000536361.1_Nonsense_Mutation_p.Q291*	NM_005687.3	NP_005678.3	Q9NSD9	SYFB_HUMAN	phenylalanyl-tRNA synthetase, beta subunit	390					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|RNA binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	24		Renal(207;0.0183)		Epithelial(121;3.47e-10)|all cancers(144;1.86e-07)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.011)	L-Phenylalanine(DB00120)	AATCTTACTTGATTAGCTATG	0.363000													26	141					0	0	1	0	0
FAM174A	345757	broad.mit.edu	37	5	99871249	99871249	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:99871249G>T	ENST00000312637.4	+	1	241	c.15G>T	c.(13-15)caG>caT	p.Q5H		NM_198507.1	NP_940909.1	Q8TBP5	F174A_HUMAN	family with sequence similarity 174, member A	5						integral to membrane				breast(2)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						AGGCCTCGCAGTGCTGCTGCT	0.672000													31	77					2.61193e-14	3.23444e-14	1	1	0
CTSC	1075	broad.mit.edu	37	11	88027416	88027416	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:88027416T>C	ENST00000227266.5	-	7	1264	c.1150A>G	c.(1150-1152)Aaa>Gaa	p.K384E		NM_001814.4	NP_001805.3	P53634	CATC_HUMAN	cathepsin C	384					immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				ATCCCCTTTTTGTAGTGGAGG	0.483000													26	83					0	0	1	0	0
SLC27A1	376497	broad.mit.edu	37	19	17599678	17599678	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:17599678C>T	ENST00000252595.7	+	5	913	c.816C>T	c.(814-816)ttC>ttT	p.F272F	SLC27A1_ENST00000442725.1_Silent_p.F272F|SLC27A1_ENST00000598424.1_Silent_p.F93F	NM_198580.1	NP_940982.1	Q6PCB7	S27A1_HUMAN	solute carrier family 27 (fatty acid transporter), member 1	272	Sufficient for oligomerization (By similarity).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TGGCAGCCTTCGGCCACCACG	0.657000													7	23					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93797562	93797562	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:93797562C>G	ENST00000315765.9	+	4	702	c.694C>G	c.(694-696)Ctt>Gtt	p.L232V		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	232	Plastocyanin-like 2.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AATGTTTACTCTTGTGGATGA	0.393000													9	33					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32740623	32740623	+	Nonsense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:32740623G>T	ENST00000333070.4	+	4	317	c.217G>T	c.(217-219)Gag>Tag	p.E73*	LCK_ENST00000373564.3_Nonsense_Mutation_p.E131*|LCK_ENST00000336890.5_Nonsense_Mutation_p.E73*	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	73	SH3.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	GCACAGCTATGAGCCCTCTCA	0.597000			T	TRB@	T-ALL								20	94					7.87624e-14	9.65685e-14	1	1	0
HECTD4	283450	broad.mit.edu	37	12	112616995	112616995	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:112616995C>T	ENST00000550722.1	-	63	11151	c.10756G>A	c.(10756-10758)Gag>Aag	p.E3586K	HECTD4_ENST00000430131.2_Missense_Mutation_p.E3310K|HECTD4_ENST00000377560.5_Missense_Mutation_p.E3560K	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		AGCTGATCCTCCAGCACCTTT	0.607000													8	18					0	0	1	0	0
TCEB2	6923	broad.mit.edu	37	16	2821499	2821499	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:2821499G>A	ENST00000262306.7	-	5	497	c.460C>T	c.(460-462)Cag>Tag	p.Q154*	TCEB2_ENST00000409906.4_3'UTR|TCEB2_ENST00000409477.1_3'UTR	NM_207013.2	NP_996896.1	Q15370	ELOB_HUMAN	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	0					positive regulation of viral transcription|protein complex assembly|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	cytosol|nucleoplasm	protein binding			endometrium(2)|prostate(1)	3						GGGTGGACCTGTGTGGGTCCG	0.547000													24	101					0	0	1	0	0
MCTP1	79772	broad.mit.edu	37	5	94050520	94050520	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:94050520G>A	ENST00000515393.1	-	20	2681	c.2682C>T	c.(2680-2682)atC>atT	p.I894I	MCTP1_ENST00000312216.8_Silent_p.I673I|MCTP1_ENST00000514040.1_5'UTR|MCTP1_ENST00000505078.1_Silent_p.I410I|ANKRD32_ENST00000493934.1_Intron|MCTP1_ENST00000429576.2_Silent_p.I587I	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	894					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		CTTCATCTAGGATGTTCTGGA	0.398000													20	187					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216138672	216138672	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:216138672G>C	ENST00000366943.2	-	37	7493	c.7107C>G	c.(7105-7107)ttC>ttG	p.F2369L	USH2A_ENST00000307340.3_Missense_Mutation_p.F2369L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2369	Fibronectin type-III 10.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.F2369L(2)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGTCTACATAGAATATCCCAG	0.358000										HNSCC(13;0.011)			12	210					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	117884901	117884901	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:117884901C>G	ENST00000439649.3	-	5	953	c.586G>C	c.(586-588)Gac>Cac	p.D196H	GFRA1_ENST00000544592.1_Missense_Mutation_p.D80H|GFRA1_ENST00000369236.1_Missense_Mutation_p.D196H|GFRA1_ENST00000355422.6_Missense_Mutation_p.D201H	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	201					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		GGGACCTTGTCAAAGAACTGC	0.617000													7	40					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3721925	3721925	+	Silent	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:3721925G>C	ENST00000324932.7	-	24	4077	c.3657C>G	c.(3655-3657)ctC>ctG	p.L1219L	NUP98_ENST00000359171.4_Silent_p.L1219L|NUP98_ENST00000355260.3_Silent_p.L1219L	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1236					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TGGGGACAATGAGAGGACACA	0.423000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								9	67					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52439700	52439700	+	Missense_Mutation	SNP	A	A	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr13:52439700A>G	ENST00000242819.4	+	2	482	c.186A>G	c.(184-186)atA>atG	p.I62M		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	62						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		GTGAAAAAATAGAGGACTTCA	0.488000													23	107					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154859918	154859918	+	Splice_Site	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:154859918T>A	ENST00000460393.1	+	11	1214		c.e11+2		MME_ENST00000493237.1_Splice_Site|MME_ENST00000360490.2_Splice_Site|MME_ENST00000462745.1_Splice_Site|MME_ENST00000492661.1_Splice_Site	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase						cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	TTCTGCCAGGTAGGTATGTCA	0.388000													51	265					0	0	1	0	0
ZNF341	84905	broad.mit.edu	37	20	32341159	32341159	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:32341159C>T	ENST00000375200.1	+	5	1036	c.671C>T	c.(670-672)gCt>gTt	p.A224V	ZNF341_ENST00000342427.2_Missense_Mutation_p.A224V			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	224					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						TACAGTGCTGCTGCGCCCCTG	0.687000													3	20					0	0	1	0	0
KIN	22944	broad.mit.edu	37	10	7801920	7801920	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:7801920C>T	ENST00000379562.3	-	12	1099	c.1052G>A	c.(1051-1053)aGa>aAa	p.R351K	KIN_ENST00000543003.1_Missense_Mutation_p.R245K|KIN_ENST00000463666.1_5'UTR|KIN_ENST00000535925.1_Missense_Mutation_p.R351K			O60870	KIN17_HUMAN	KIN, antigenic determinant of recA protein homolog (mouse)	351	C-terminal subdomain B.				DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						TTCATTTCCTCTGTAGCCTCC	0.308000													7	76					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33526632	33526632	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:33526632G>T	ENST00000404816.2	+	22	3755	c.3402G>T	c.(3400-3402)caG>caT	p.Q1134H	LTBP1_ENST00000498013.1_3'UTR|LTBP1_ENST00000407925.1_Missense_Mutation_p.Q808H|LTBP1_ENST00000272273.5_Missense_Mutation_p.Q74H|LTBP1_ENST00000404525.1_Missense_Mutation_p.Q755H|LTBP1_ENST00000402934.1_Missense_Mutation_p.Q755H|LTBP1_ENST00000390003.4_Missense_Mutation_p.Q809H|LTBP1_ENST00000354476.3_Missense_Mutation_p.Q1135H|LTBP1_ENST00000418533.2_Missense_Mutation_p.Q808H			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1134	EGF-like 10; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CTCATGGGCAGTGCAGGAACA	0.458000													10	86					1.76689e-08	2.0322e-08	1	1	0
ANKRD30BP3	338579	broad.mit.edu	37	10	45652248	45652248	+	RNA	SNP	T	T	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:45652248T>A	ENST00000427229.2	+	0	1762																											AAGGAACACCTGATGAGGCTG	0.488000													9	20					0	0	1	0	0
NIPA2	81614	broad.mit.edu	37	15	23012297	23012297	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:23012297G>A	ENST00000337451.3	-	7	1042	c.430C>T	c.(430-432)Cac>Tac	p.H144Y	NIPA2_ENST00000359727.4_Missense_Mutation_p.H125Y|NIPA2_ENST00000398014.2_Missense_Mutation_p.H144Y|NIPA2_ENST00000539711.2_Missense_Mutation_p.H125Y|NIPA2_ENST00000398013.3_Missense_Mutation_p.H144Y	NM_030922.6	NP_112184.4	Q8N8Q9	NIPA2_HUMAN	non imprinted in Prader-Willi/Angelman syndrome 2	144						early endosome|integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(4)|skin(1)	15		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;1.48e-06)|Epithelial(43;1.44e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000353)		CCTAGCTTGTGAGACATTTCA	0.328000													5	96					0	0	1	0	0
CENPB	1059	broad.mit.edu	37	20	3766766	3766766	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:3766766C>A	ENST00000379751.4	-	1	571	c.365G>T	c.(364-366)tGg>tTg	p.W122L		NM_001810.5	NP_001801.1	P07199	CENPB_HUMAN	centromere protein B, 80kDa	122	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)	8						GCGGTCCAGCCAGCCGTTGGA	0.756000													8	69					0.00307968	0.00317806	1	1	0
CXCL3	2921	broad.mit.edu	37	4	74902980	74902980	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:74902980C>T	ENST00000296026.4	-	4	400	c.323G>A	c.(322-324)tGa>tAa	p.*108*	CXCL3_ENST00000511669.1_5'UTR	NM_002090.2	NP_002081.2	P19876	CXCL3_HUMAN	chemokine (C-X-C motif) ligand 3	0					immune response|inflammatory response|neutrophil chemotaxis	extracellular space	chemokine activity			central_nervous_system(1)|endometrium(1)	2	Breast(15;0.00612)		all cancers(17;0.00273)|Lung(101;0.196)			TCTCTCCTGTCAGTTGGTGCT	0.498000													18	61					0	0	1	0	0
HIF1AN	55662	broad.mit.edu	37	10	102300526	102300526	+	Silent	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:102300526C>A	ENST00000299163.5	+	3	664	c.564C>A	c.(562-564)ctC>ctA	p.L188L		NM_017902.2	NP_060372.2	Q9NWT6	HIF1N_HUMAN	hypoxia inducible factor 1, alpha subunit inhibitor	188	Interaction with HIF1A.|Interaction with VHL.|JmjC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(1)|prostate(2)|urinary_tract(1)	10		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		ACCTGCTGCTCATTGGCATGG	0.448000													14	48					4.3838e-07	4.86144e-07	1	1	0
PCDHGA12	26025	broad.mit.edu	37	5	140812230	140812230	+	Missense_Mutation	SNP	G	G	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:140812230G>T	ENST00000252085.3	+	1	2046	c.1904G>T	c.(1903-1905)aGa>aTa	p.R635I	PCDHGA1_ENST00000517417.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCTGGACAGAGACGCGCTC	0.697000													26	100					9.39395e-14	1.14609e-13	1	1	0
RBM43	375287	broad.mit.edu	37	2	152108144	152108144	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:152108144G>A	ENST00000331426.5	-	4	501	c.350C>T	c.(349-351)tCt>tTt	p.S117F		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	117							nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		TCCAAAAACAGAAAGATCAAG	0.353000													16	89					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48520719	48520719	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr7:48520719G>A	ENST00000435803.1	+	46	13086	c.13062G>A	c.(13060-13062)gaG>gaA	p.E4354E	ABCA13_ENST00000544596.1_Silent_p.E84E	NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4354					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCAATATGGAGGAGTACTTGC	0.413000													4	11					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16895717	16895717	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:16895717G>A	ENST00000430580.2	-	23	3352	c.2465C>T	c.(2464-2466)tCt>tTt	p.S822F	NBPF1_ENST00000432949.1_Intron|NBPF1_ENST00000420031.2_3'UTR|NBPF1_ENST00000287968.8_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	822	NBPF 4.|Poly-Glu.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CTCCTCTTCAGACTCCTGCAG	0.488000													11	301					0	0	1	0	0
TRMT10C	54931	broad.mit.edu	37	3	101284217	101284217	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:101284217G>C	ENST00000309922.6	+	2	746	c.592G>C	c.(592-594)Gcc>Ccc	p.A198P		NM_017819.2	NP_060289.2			tRNA methyltransferase 10 homolog C (S. cerevisiae)																		GGGTGCCCAGGCCATGCAGTT	0.398000													22	78					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70513317	70513317	+	Nonsense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:70513317C>A	ENST00000503640.1	-	1	101	c.46G>T	c.(46-48)Gga>Tga	p.G16*	UGT2A1_ENST00000514019.1_Nonsense_Mutation_p.G16*|UGT2A1_ENST00000286604.4_Nonsense_Mutation_p.G16*|UGT2A1_ENST00000512704.1_Nonsense_Mutation_p.G16*	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	16					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						AGAGTGGTTCCTATGAGACTT	0.378000													9	30					5.4927e-09	6.36674e-09	1	1	0
NELL1	4745	broad.mit.edu	37	11	20959343	20959343	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:20959343T>C	ENST00000298925.5	+	11	1246	c.1093T>C	c.(1093-1095)Tat>Cat	p.Y365H	NELL1_ENST00000532434.1_Missense_Mutation_p.Y337H|NELL1_ENST00000325319.5_Missense_Mutation_p.Y280H|NELL1_ENST00000357134.5_Missense_Mutation_p.Y337H			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	337	VWFC 2.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						AAAATGTATCTATGGAGGAAA	0.418000													21	61					0	0	1	0	0
FANCD2OS	115795	broad.mit.edu	37	3	10145979	10145979	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:10145979G>A	ENST00000450660.2	-	2	696	c.480C>T	c.(478-480)ctC>ctT	p.L160L	FANCD2OS_ENST00000524279.1_Silent_p.L160L	NM_001164839.1	NP_001158311.1			FANCD2 opposite strand																		CATACAGCAAGAGGATAGAGC	0.478000													10	67					0	0	1	0	0
FAM26F	441168	broad.mit.edu	37	6	116784478	116784478	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:116784478C>T	ENST00000368605.1	+	3	653	c.558C>T	c.(556-558)atC>atT	p.I186I	FAM26F_ENST00000368606.3_Silent_p.I14I|RP1-93H18.6_ENST00000476099.1_RNA	NM_001010919.1	NP_001010919.1	Q5R3K3	FA26F_HUMAN	family with sequence similarity 26, member F	186						integral to membrane				large_intestine(2)|lung(1)	3				GBM - Glioblastoma multiforme(226;0.0402)|all cancers(137;0.0627)|OV - Ovarian serous cystadenocarcinoma(136;0.0655)|Epithelial(106;0.231)		CAGTTGTTATCATCATTCTTC	0.353000													30	96					0	0	1	0	0
TRDMT1	1787	broad.mit.edu	37	10	17210880	17210880	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr10:17210880C>A	ENST00000377799.3	-	3	258	c.211G>T	c.(211-213)Gat>Tat	p.D71Y	TRDMT1_ENST00000358282.7_Intron|TRDMT1_ENST00000488990.1_Intron|TRDMT1_ENST00000377766.5_Intron|TRDMT1_ENST00000412821.3_Missense_Mutation_p.D71Y|TRDMT1_ENST00000457442.2_Intron|TRDMT1_ENST00000351358.4_Missense_Mutation_p.D71Y|TRDMT1_ENST00000452380.2_5'UTR	NM_004412.5	NP_004403.1	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1	71					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding	p.D71N(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	18						AAAATCATATCAAAAGATAAT	0.383000													7	25					0.000274275	0.000288649	1	1	0
MAST2	23139	broad.mit.edu	37	1	46295119	46295119	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:46295119C>A	ENST00000361297.2	+	3	617	c.334C>A	c.(334-336)Ctg>Atg	p.L112M	MAST2_ENST00000372009.2_Missense_Mutation_p.L112M	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	112					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					AGGTAAGCAGCTGCTCCCTTT	0.388000													11	77					1.61879e-10	1.9031e-10	1	1	0
ACACB	32	broad.mit.edu	37	12	109679001	109679001	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:109679001C>T	ENST00000338432.7	+	36	5056	c.4937C>T	c.(4936-4938)cCc>cTc	p.P1646L	ACACB_ENST00000377854.5_Missense_Mutation_p.P1576L|ACACB_ENST00000377848.3_Missense_Mutation_p.P1646L|ACACB_ENST00000543201.1_Missense_Mutation_p.P312L			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1646					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AGTGCCGTTCCCATCCGCCTG	0.562000													60	190					0	0	1	0	0
STK3	6788	broad.mit.edu	37	8	99719466	99719466	+	Missense_Mutation	SNP	T	T	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr8:99719466T>C	ENST00000523601.1	-	7	908	c.509A>G	c.(508-510)aAa>aGa	p.K170R	STK3_ENST00000419617.2_Missense_Mutation_p.K142R	NM_001256312.1	NP_001243241.1	Q13188	STK3_HUMAN	serine/threonine kinase 3	142	Protein kinase.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		TCTGTGTATTTTTCTCATAAA	0.308000													7	14					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95566440	95566440	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr12:95566440G>A	ENST00000343958.4	-	3	2745	c.2522C>T	c.(2521-2523)tCt>tTt	p.S841F	FGD6_ENST00000549499.1_Missense_Mutation_p.S841F|FGD6_ENST00000546711.1_Missense_Mutation_p.S841F	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	841					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						ATCTTCATCAGAACTGTTGAT	0.453000													38	128					0	0	1	0	0
ZNF45	7596	broad.mit.edu	37	19	44423752	44423752	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:44423752C>T	ENST00000269973.5	-	8	1205	c.115G>A	c.(115-117)Gag>Aag	p.E39K	RP11-15A1.2_ENST00000586247.1_RNA|ZNF45_ENST00000589703.1_Missense_Mutation_p.E39K	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	39	KRAB.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						CTGAAGTTCTCCAGCATCACA	0.537000													10	162					0	0	1	0	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74819794	74819794	+	Missense_Mutation	SNP	G	G	C			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:74819794G>C	ENST00000370895.1	+	13	1496	c.1461G>C	c.(1459-1461)ttG>ttC	p.L487F	FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.L487F|TNNI3K_ENST00000326637.3_Missense_Mutation_p.L386F|RP11-439H8.4_ENST00000415549.2_RNA|FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.L487F|TNNI3K_ENST00000370891.2_Missense_Mutation_p.L487F			Q59H18	TNI3K_HUMAN		386	Protein kinase.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										AGACATGTTTGATGTGGGCTT	0.378000													24	122					0	0	1	0	0
XPO6	23214	broad.mit.edu	37	16	28167757	28167757	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr16:28167757G>A	ENST00000304658.5	-	7	1235	c.735C>T	c.(733-735)atC>atT	p.I245I	XPO6_ENST00000565698.1_Silent_p.I231I	NM_015171.2	NP_055986.1	Q96QU8	XPO6_HUMAN	exportin 6	245					protein export from nucleus		protein binding|protein transporter activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	25						CCAGGGAACAGATATACTCAC	0.493000													24	77					0	0	1	0	0
KIAA1191	57179	broad.mit.edu	37	5	175775307	175775307	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:175775307G>A	ENST00000298569.4	-	7	1045	c.512C>T	c.(511-513)tCa>tTa	p.S171L	KIAA1191_ENST00000393725.2_Missense_Mutation_p.S152L|RP11-843P14.2_ENST00000508187.1_RNA|KIAA1191_ENST00000393728.2_5'UTR|KIAA1191_ENST00000533553.1_Silent_p.I27I|KIAA1191_ENST00000510164.1_Missense_Mutation_p.S171L	NM_020444.3	NP_065177.2	Q96A73	K1191_HUMAN	KIAA1191	171							protein binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6	all_cancers(89;0.00575)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.101)		GGACTGGGCTGATGCAGGCTG	0.498000													15	59					0	0	1	0	0
MYLK4	340156	broad.mit.edu	37	6	2685801	2685801	+	Silent	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:2685801G>A	ENST00000274643.7	-	5	693	c.351C>T	c.(349-351)ttC>ttT	p.F117F	MYLK4_ENST00000268446.5_Silent_p.F117F	NM_001012418.3	NP_001012418.2	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	117	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				GAACCTGGCCGAAACGCCCTC	0.582000													6	125					0	0	1	0	0
C6orf1	221491	broad.mit.edu	37	6	34214850	34214850	+	Missense_Mutation	SNP	C	C	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:34214850C>G	ENST00000476320.1	-	4	778	c.96G>C	c.(94-96)agG>agC	p.R32S	C6orf1_ENST00000481533.1_Missense_Mutation_p.R32S|C6orf1_ENST00000335352.3_Missense_Mutation_p.R12S|C6orf1_ENST00000394990.4_Missense_Mutation_p.R32S|C6orf1_ENST00000413013.2_Missense_Mutation_p.R12S|C6orf1_ENST00000468145.1_Missense_Mutation_p.R32S	NM_001008703.1	NP_001008703.1	Q86T20	CF001_HUMAN	chromosome 6 open reading frame 1	32						extracellular region				endometrium(1)|prostate(1)	2		Ovarian(999;0.0228)		BRCA - Breast invasive adenocarcinoma(397;1.11e-10)		GAGAGCAGCTCCTGCTCAGCC	0.632000											OREG0017364	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	182					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92568196	92568196	+	Missense_Mutation	SNP	C	C	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr11:92568196C>A	ENST00000298047.6	+	14	10049	c.10032C>A	c.(10030-10032)gaC>gaA	p.D3344E	FAT3_ENST00000409404.2_Missense_Mutation_p.D3344E|FAT3_ENST00000525166.1_Missense_Mutation_p.D3194E			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3344	Cadherin 31.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCAGCCAAGACGTCTACAGTG	0.527000										TCGA Ovarian(4;0.039)			6	30					0.0293803	0.0297406	1	1	0
SULF2	55959	broad.mit.edu	37	20	46313262	46313262	+	Silent	SNP	G	G	T	rs114802841	by1000genomes	TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:46313262G>T	ENST00000359930.4	-	6	1652	c.801C>A	c.(799-801)ccC>ccA	p.P267P	SULF2_ENST00000484875.1_Silent_p.P267P|SULF2_ENST00000467815.1_Silent_p.P267P|SULF2_ENST00000361612.4_Silent_p.P267P|CTD-2653D5.1_ENST00000526566.2_RNA	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	267					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						TGGGCTTCATGGGCCCCGTGT	0.602000													9	35					3.09899e-07	3.44693e-07	1	1	0
CTSS	1520	broad.mit.edu	37	1	150737202	150737202	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:150737202G>A	ENST00000368985.3	-	2	298	c.38C>T	c.(37-39)tCt>tTt	p.S13F	CTSS_ENST00000448301.2_Missense_Mutation_p.S13F	NM_001199739.1|NM_004079.4	NP_001186668.1|NP_004070.3	P25774	CATS_HUMAN	cathepsin S	13					immune response|proteolysis	extracellular region|lysosome	cysteine-type endopeptidase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	15	all_cancers(9;6.17e-52)|all_epithelial(9;9.7e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.00146)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|Epithelial(6;5.02e-21)|all cancers(9;1.28e-20)|OV - Ovarian serous cystadenocarcinoma(6;1.09e-14)|BRCA - Breast invasive adenocarcinoma(12;0.00501)|LUSC - Lung squamous cell carcinoma(543;0.171)			TGCCACTGCAGAGGAGCACAC	0.443000													43	188					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142188994	142188994	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:142188994G>A	ENST00000350721.4	-	37	6374	c.6253C>T	c.(6253-6255)Cag>Tag	p.Q2085*	RP11-383G6.3_ENST00000460977.1_RNA|ATR_ENST00000383101.3_Nonsense_Mutation_p.Q2021*	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	2085	FAT.				cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						GGCATTGACTGATATATGAAC	0.299000								Other conserved DNA damage response genes					8	25					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156640912	156640912	+	Missense_Mutation	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:156640912C>T	ENST00000368223.3	-	4	3200	c.3068G>A	c.(3067-3069)aGa>aAa	p.R1023K		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1023	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AACCAGGCCTCTCTGCTCTTT	0.657000													20	390					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55168206	55168206	+	Silent	SNP	C	C	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:55168206C>T	ENST00000396834.1	+	6	820	c.324C>T	c.(322-324)acC>acT	p.T108T	IL31RA_ENST00000447346.2_Silent_p.T127T|IL31RA_ENST00000297015.3_5'UTR|IL31RA_ENST00000490985.1_5'UTR|IL31RA_ENST00000396836.2_Silent_p.T127T|IL31RA_ENST00000359040.5_Silent_p.T127T|IL31RA_ENST00000354961.4_Silent_p.T108T	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	95	Fibronectin type-III 1.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				ATAATTATACCATTGAGGTGG	0.333000													19	84					0	0	1	0	0
IFI16	3428	broad.mit.edu	37	1	159023471	159023471	+	Missense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:159023471G>A	ENST00000295809.7	+	11	2489	c.2234G>A	c.(2233-2235)gGg>gAg	p.G745E	IFI16_ENST00000340979.6_Missense_Mutation_p.G633E|IFI16_ENST00000359709.3_Missense_Mutation_p.G689E|IFI16_ENST00000368132.3_Missense_Mutation_p.G689E|IFI16_ENST00000448393.2_Missense_Mutation_p.G633E|IFI16_ENST00000430894.2_Missense_Mutation_p.G693E|IFI16_ENST00000368131.4_Missense_Mutation_p.G689E			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	745	HIN-200 2.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					CCGAAAAGTGGGAATACCGGG	0.423000													30	189					0	0	1	0	0
CENPB	1059	broad.mit.edu	37	20	3766566	3766566	+	Nonsense_Mutation	SNP	G	G	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr20:3766566G>A	ENST00000379751.4	-	1	771	c.565C>T	c.(565-567)Cag>Tag	p.Q189*		NM_001810.5	NP_001801.1	P07199	CENPB_HUMAN	centromere protein B, 80kDa	189					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|satellite DNA binding			kidney(1)|large_intestine(2)|lung(4)|skin(1)	8						AACACGTCCTGCGAGGCGTAG	0.726000													12	50					0	0	1	0	0
HTR1D	3352	broad.mit.edu	37	1	23520424	23520424	+	Frame_Shift_Del	DEL	C	C	-	rs41268111		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:23520424delC	ENST00000374619.1	-	1	798	c.289delG	c.(289-291)ccfs	p.A97fs	HTR1D_ENST00000314113.3_Frame_Shift_Del_p.A97fs	NM_000864.4	NP_000855.1	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	97					G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity			NS(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	ATGGTATAGGCGATGCTGATG	0.547													44	181	---	---	---	---					
AMY1A	276	broad.mit.edu	37	1	104203093	104203094	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:104203093_104203094insTT	ENST00000370083.4	+	7	1210_1211	c.990_991insTT	c.(988-993)ttgggafs	p.LG330fs		NM_001008221.1|NM_004038.3	NP_001008222.1|NP_004029.2			amylase, alpha 1A (salivary)														all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)		TACTTACCTTCTGGGATGCTAG	0.376													30	812	---	---	---	---					
RGS2	5997	broad.mit.edu	37	1	192778220	192778220	+	Frame_Shift_Del	DEL	T	T	-			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:192778220delT	ENST00000235382.5	+	1	50	c.19delT	c.(19-21)tgfs	p.L7fs	RGS2_ENST00000483295.1_3'UTR	NM_002923.3	NP_002914.1	P41220	RGS2_HUMAN	regulator of G-protein signaling 2, 24kDa	7					cell cycle|negative regulation of cardiac muscle hypertrophy|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of MAP kinase activity|negative regulation of phospholipase activity|positive regulation of cardiac muscle contraction|regulation of adrenergic receptor signaling pathway|regulation of translation|relaxation of cardiac muscle	cytosol|internal side of plasma membrane|mitochondrion|nucleolus	calmodulin binding|GTPase activator activity|signal transducer activity			large_intestine(3)|lung(1)|urinary_tract(1)	5						TGCTATGTTCTTGGCTGTTCA	0.587													21	121	---	---	---	---					
OR11L1	391189	broad.mit.edu	37	1	248004562	248004563	+	Frame_Shift_Ins	INS	-	-	A			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr1:248004562_248004563insA	ENST00000355784.2	-	1	691_692	c.636_637insT	c.(634-639)tttgacfs	p.D213fs		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L213L(1)		NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCCAGTGTCAGAAAAAAACAAA	0.515													25	135	---	---	---	---					
NR4A2	4929	broad.mit.edu	37	2	157186105	157186105	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr2:157186105delC	ENST00000339562.4	-	3	956	c.594delG	c.(592-594)ctfs	p.L198fs	NR4A2_ENST00000429376.1_Frame_Shift_Del_p.L135fs|NR4A2_ENST00000539077.1_Frame_Shift_Del_p.L209fs|NR4A2_ENST00000409108.2_Frame_Shift_Del_p.L198fs|NR4A2_ENST00000426264.1_Frame_Shift_Del_p.L135fs|NR4A2_ENST00000409572.1_Frame_Shift_Del_p.L198fs	NM_006186.3	NP_006177.1	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	198	Pro-rich.				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	40						TGGGGACGTGCAGGGGCCCGT	0.662													18	102	---	---	---	---					
CD96	10225	broad.mit.edu	37	3	111197863	111197868	+	RNA	DEL	CACACA	CACACA	-	rs71968470		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr3:111197863_111197868delCACACA	ENST00000497896.1	-	0	208																											CGAACAGCCTcacacacacacacaca	0.544													3	5	---	---	---	---					
OTOP1	133060	broad.mit.edu	37	4	4204225	4204229	+	Frame_Shift_Del	DEL	TTGAG	TTGAG	-			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr4:4204225_4204229delTTGAG	ENST00000296358.4	-	4	700_704	c.676_680delCTCAA	c.(676-681)tfs	p.LN226fs		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	226					biomineral tissue development	extracellular space|integral to membrane		p.L226fs*1(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTTGTGCTCATTGAGTTGGTGCTTT	0.502													7	157	---	---	---	---					
PCDHGB2	56103	broad.mit.edu	37	5	140741900	140741900	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr5:140741900delC	ENST00000522605.1	+	1	2198	c.2198delC	c.(2197-2199)tcfs	p.S733fs	PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTCTCAGCTCCAAGCCTGGA	0.532													39	154	---	---	---	---					
FAM229B	619208	broad.mit.edu	37	6	112420561	112420561	+	Frame_Shift_Del	DEL	T	T	-			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr6:112420561delT	ENST00000368656.2	+	3	372	c.75delT	c.(73-75)ccfs	p.P25fs	FAM229B_ENST00000604268.1_Frame_Shift_Del_p.P25fs	NM_001033564.1	NP_001028736.1			family with sequence similarity 229, member B																		AGCTGGAACCTGGGCTGAGCT	0.468													25	44	---	---	---	---					
CACNA1B	774	broad.mit.edu	37	9	140995585	140995586	+	Frame_Shift_Ins	INS	-	-	T			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr9:140995585_140995586insT	ENST00000371365.2	+	4	389_390	c.344_345insT	c.(343-345)attfs	p.I115fs	CACNA1B_ENST00000371357.1_Intron|CACNA1B_ENST00000371372.1_Intron|CACNA1B_ENST00000277549.5_Intron|CACNA1B_ENST00000371363.1_Intron|CACNA1B_ENST00000371355.4_Intron|CACNA1B_ENST00000277551.2_Intron			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1751					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	GATATGTACAGTTTGTTGCGTT	0.520													11	26	---	---	---	---					
ABHD12B	145447	broad.mit.edu	37	14	51347246	51347246	+	Frame_Shift_Del	DEL	G	G	-			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr14:51347246delG	ENST00000337334.2	+	4	427	c.412delG	c.(412-414)ggfs	p.G138fs	ABHD12B_ENST00000353130.1_Frame_Shift_Del_p.G61fs|ABHD12B_ENST00000395752.1_Frame_Shift_Del_p.G31fs|PYGL_ENST00000532462.1_Intron|ABHD12B_ENST00000554241.1_3'UTR	NM_001206673.1	NP_001193602.1	Q7Z5M8	AB12B_HUMAN	abhydrolase domain containing 12B	138							hydrolase activity			breast(2)|endometrium(1)|large_intestine(2)|lung(5)	10	all_epithelial(31;0.00481)|Breast(41;0.148)					CCTTCGTGATGGGAACCCAAT	0.498													71	88	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25485171	25485172	+	RNA	INS	-	-	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:25485171_25485172insG	ENST00000453082.2	+	0	1979					NR_003343.1																						GGCATCTGGAAGGGGGCCCAGC	0.604													21	65	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													3	6	---	---	---	---					
AC015922.5	0	broad.mit.edu	37	17	15737072	15737073	+	RNA	INS	-	-	TTTA	rs71838018		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:15737072_15737073insTTTA	ENST00000584636.1	+	0	316																											CTCTATCCTGCTTTATCTTGGA	0.460													2	4	---	---	---	---					
LOC100131347	100131347	broad.mit.edu	37	17	37213525	37213526	+	RNA	INS	-	-	TTTTG	rs59291335		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr17:37213525_37213526insTTTTG	ENST00000583447.1	+	0	141					NR_036551.1																						CTGAAGGACTCttttttttttt	0.550													3	3	---	---	---	---					
TUBB4A	10382	broad.mit.edu	37	19	6495311	6495311	+	Frame_Shift_Del	DEL	C	C	-			TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:6495311delC	ENST00000264071.2	-	4	1570	c.1199delG	c.(1198-1200)gcfs	p.G400fs	TUBB4A_ENST00000540257.1_Frame_Shift_Del_p.G400fs			P04350	TBB4_HUMAN	tubulin, beta 4A class IVa	400					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity										CATGCCCTCGCCCGTGTACCA	0.607													67	222	---	---	---	---					
CTC-260E6.6	0	broad.mit.edu	37	19	20262849	20262850	+	RNA	INS	-	-	T	rs142097873		TCGA-NJ-A4YP-01A-11D-A25L-08	TCGA-NJ-A4YP-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	D9B15255-519F-4401-9CB5-B5DD3982C8E3	16880AEE-819E-478A-8826-0812B8802E08	g.chr19:20262849_20262850insT	ENST00000593655.1	-	0	337				CTC-260E6.6_ENST00000586657.1_RNA																							TTTCttttttcttttttttttt	0.470													3	4	---	---	---	---