Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
CCDC27	148870	broad.mit.edu	37	1	3686367	3686367	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:3686367G>A	uc001akv.2	+	11	1845	c.1764G>A	c.(1762-1764)AAG>AAA	p.K588K	LOC388588_uc001akw.3_5'Flank	NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	588										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		TAAGGAATAAGATCATCCAGG	0.542													8	44	---	---	---	---	PASS
PRAMEF1	65121	broad.mit.edu	37	1	12854302	12854302	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:12854302G>A	uc001auj.1	+	3	629	c.526G>A	c.(526-528)GGT>AGT	p.G176S		NM_023013	NP_075389	O95521	PRAM1_HUMAN	PRAME family member 1	176											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CCAAAGGAGAGGTTTAGTACA	0.408													33	161	---	---	---	---	PASS
EPHA2	1969	broad.mit.edu	37	1	16458597	16458597	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:16458597C>T	uc001aya.1	-	13	2424	c.2287G>A	c.(2287-2289)GTG>ATG	p.V763M		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	763	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.|Cytoplasmic (Potential).				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	TCCTCCAGCACGCGGGACAGG	0.612													9	39	---	---	---	---	PASS
CELA3A	10136	broad.mit.edu	37	1	22336260	22336260	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:22336260G>T	uc001bfl.2	+	7	724	c.705G>T	c.(703-705)GTG>GTT	p.V235V		NM_005747	NP_005738	P09093	CEL3A_HUMAN	elastase 3A, pancreatic preproprotein	235	Peptidase S1.				cholesterol metabolic process|digestion|proteolysis		serine-type endopeptidase activity			haematopoietic_and_lymphoid_tissue(1)	1						TCCACGGTGTGACCAGCTTTG	0.592													4	25	---	---	---	---	PASS
CLSPN	63967	broad.mit.edu	37	1	36204180	36204180	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:36204180T>C	uc001bzi.2	-	21	3514	c.3434A>G	c.(3433-3435)GAT>GGT	p.D1145G	CLSPN_uc009vux.2_Missense_Mutation_p.D1081G	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin	1145					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CTGGGAAGCATCATCTAAACA	0.433													11	34	---	---	---	---	PASS
MACF1	23499	broad.mit.edu	37	1	39799732	39799732	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:39799732G>T	uc010oiu.1	+	1	2923	c.2792G>T	c.(2791-2793)AGA>ATA	p.R931I	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc001cdb.1_Intron	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	2496					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTTTTGGAGAGAGAGGAGGCC	0.403													5	99	---	---	---	---	PASS
DAB1	1600	broad.mit.edu	37	1	57602295	57602295	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:57602295C>T	uc001cys.1	-	6	901	c.227G>A	c.(226-228)CGT>CAT	p.R76H	DAB1_uc001cyt.1_Missense_Mutation_p.R76H|DAB1_uc001cyq.1_Missense_Mutation_p.R76H|DAB1_uc001cyr.1_Missense_Mutation_p.R76H|DAB1_uc009vzw.1_Missense_Mutation_p.R76H|DAB1_uc009vzx.1_Missense_Mutation_p.R76H	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	76	PID.				cell differentiation|nervous system development					skin(2)|ovary(1)	3						TCCTTTGGAACGAGCGCCAGC	0.403													5	20	---	---	---	---	PASS
C1orf173	127254	broad.mit.edu	37	1	75037053	75037053	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:75037053C>G	uc001dgg.2	-	14	4560	c.4341G>C	c.(4339-4341)GAG>GAC	p.E1447D		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1447	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CTTCCTCTTGCTCCTGTCCTA	0.587													11	46	---	---	---	---	PASS
AK5	26289	broad.mit.edu	37	1	77752691	77752691	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:77752691A>C	uc001dhn.2	+	2	383	c.126A>C	c.(124-126)TTA>TTC	p.L42F	AK5_uc001dho.2_Missense_Mutation_p.L16F|AK5_uc001dhm.1_Missense_Mutation_p.L42F	NM_174858	NP_777283	Q9Y6K8	KAD5_HUMAN	adenylate kinase 5 isoform 1	42					ADP biosynthetic process|ATP metabolic process|dADP biosynthetic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine ribonucleotide biosynthetic process|signal transduction	centrosome|cytosol	adenylate kinase activity|ATP binding|cAMP-dependent protein kinase regulator activity|nucleoside kinase activity			skin(1)	1						AAAGTTGTTTACAAAAAGTAA	0.378													9	57	---	---	---	---	PASS
MAGI3	260425	broad.mit.edu	37	1	114184866	114184866	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:114184866C>A	uc001edk.2	+	10	1875	c.1694C>A	c.(1693-1695)TCC>TAC	p.S565Y	MAGI3_uc001edh.3_Missense_Mutation_p.S590Y|MAGI3_uc001edi.3_Missense_Mutation_p.S565Y|MAGI3_uc010owm.1_Missense_Mutation_p.S590Y|MAGI3_uc001edj.2_Missense_Mutation_p.S286Y	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	590					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGAGAGTATCCATGGCATCG	0.502													19	99	---	---	---	---	PASS
BCL2L15	440603	broad.mit.edu	37	1	114424399	114424399	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:114424399C>T	uc001edw.2	-	3	642	c.470G>A	c.(469-471)GGT>GAT	p.G157D	uc001edv.1_Intron|BCL2L15_uc001edx.2_Intron|BCL2L15_uc001edy.2_Intron|BCL2L15_uc001edz.1_RNA	NM_001010922	NP_001010922	Q5TBC7	B2L15_HUMAN	pro-apoptotic Bcl-2 protein	157					apoptosis					ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.95e-08)|all_epithelial(167;9.95e-08)|all_lung(203;1.31e-05)|Lung NSC(69;2.46e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTTACCCAACCTCCCTGGCC	0.483													13	19	---	---	---	---	PASS
CD101	9398	broad.mit.edu	37	1	117559924	117559924	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:117559924C>A	uc010oxb.1	+	5	1499	c.1441C>A	c.(1441-1443)CAT>AAT	p.H481N	CD101_uc009whd.2_Missense_Mutation_p.H481N|CD101_uc010oxc.1_Missense_Mutation_p.H481N|CD101_uc010oxd.1_Missense_Mutation_p.H419N	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	481	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						ACCCAGTTACCATGGCAACAC	0.572													6	149	---	---	---	---	PASS
MAN1A2	10905	broad.mit.edu	37	1	118039520	118039520	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:118039520G>T	uc001ehd.1	+	10	2141	c.1420G>T	c.(1420-1422)GGT>TGT	p.G474C	MAN1A2_uc009whg.1_Missense_Mutation_p.G264C	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	474	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		AGGAGCAGATGGTTCCAGAGC	0.423													7	133	---	---	---	---	PASS
HMGCS2	3158	broad.mit.edu	37	1	120293471	120293471	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:120293471C>G	uc001eid.2	-	9	1532	c.1481G>C	c.(1480-1482)CGA>CCA	p.R494P	HMGCS2_uc010oxj.1_Missense_Mutation_p.R452P|HMGCS2_uc001eie.2_Missense_Mutation_p.R402P	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	494					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		CTCGTCCACTCGCTCCAGGTA	0.512													3	44	---	---	---	---	PASS
PDE4DIP	9659	broad.mit.edu	37	1	144912276	144912276	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:144912276C>G	uc001elw.3	-	15	2290	c.1999G>C	c.(1999-2001)GTG>CTG	p.V667L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.V733L|PDE4DIP_uc001emc.1_Missense_Mutation_p.V667L|PDE4DIP_uc001emd.1_Missense_Mutation_p.V667L|PDE4DIP_uc001emb.1_Missense_Mutation_p.V830L|PDE4DIP_uc001eme.1_Missense_Mutation_p.V196L|PDE4DIP_uc001emf.1_Missense_Mutation_p.V452L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	667	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding	p.V667L(1)		ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AAGGCTTGCACCAACTTCTCT	0.383			T	PDGFRB	MPD								4	59	---	---	---	---	PASS
HRNR	388697	broad.mit.edu	37	1	152187842	152187842	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:152187842G>C	uc001ezt.1	-	3	6339	c.6263C>G	c.(6262-6264)TCC>TGC	p.S2088C		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2088	23.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGACCGACCGGAGCCAGACCC	0.617													31	90	---	---	---	---	PASS
FLG	2312	broad.mit.edu	37	1	152281741	152281741	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:152281741G>A	uc001ezu.1	-	3	5657	c.5621C>T	c.(5620-5622)TCA>TTA	p.S1874L		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1874	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCGTCTCCTGATTGTTTCTC	0.572									Ichthyosis				106	240	---	---	---	---	PASS
LCE1E	353135	broad.mit.edu	37	1	152759781	152759781	+	Silent	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:152759781C>G	uc001fan.2	+	2	59	c.6C>G	c.(4-6)TCC>TCG	p.S2S		NM_178353	NP_848130	Q5T753	LCE1E_HUMAN	late cornified envelope 1E	2					keratinization						0	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGAGATGTCCTGCCAGCAGA	0.488													18	168	---	---	---	---	PASS
NUP210L	91181	broad.mit.edu	37	1	154098875	154098875	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:154098875C>A	uc001fdw.2	-	10	1322	c.1250G>T	c.(1249-1251)GGA>GTA	p.G417V	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Missense_Mutation_p.G417V	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	417						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			ATGGTAAGATCCATTCACGGT	0.398													17	56	---	---	---	---	PASS
NUP210L	91181	broad.mit.edu	37	1	154098876	154098876	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:154098876C>A	uc001fdw.2	-	10	1321	c.1249G>T	c.(1249-1251)GGA>TGA	p.G417*	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Nonsense_Mutation_p.G417*	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	417						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TGGTAAGATCCATTCACGGTA	0.398													17	57	---	---	---	---	PASS
FLAD1	80308	broad.mit.edu	37	1	154962919	154962919	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:154962919G>A	uc001fgf.1	+	5	1823	c.1469G>A	c.(1468-1470)CGG>CAG	p.R490Q	FLAD1_uc001fgd.1_3'UTR|FLAD1_uc001fge.1_Missense_Mutation_p.R393Q|FLAD1_uc001fgg.1_Missense_Mutation_p.R393Q|FLAD1_uc001fgh.1_Intron	NM_025207	NP_079483	Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase isoform	490	FAD synthase.				FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity			ovary(2)|skin(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGCACCCGCCGGACTGACCCC	0.622													4	24	---	---	---	---	PASS
ARHGEF2	9181	broad.mit.edu	37	1	155921325	155921325	+	Splice_Site	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:155921325C>A	uc001fmt.2	-	19	2327	c.2209_splice	c.e19-1	p.E737_splice	ARHGEF2_uc001fmq.2_5'Flank|ARHGEF2_uc001fmr.2_Splice_Site_p.E709_splice|ARHGEF2_uc001fms.2_Splice_Site_p.E736_splice|ARHGEF2_uc001fmu.2_Splice_Site_p.E781_splice	NM_001162383	NP_001155855	Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor 2						actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			ovary(1)	1	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GTAACGCCTCCTGAGGACAGA	0.557													6	100	---	---	---	---	PASS
IQGAP3	128239	broad.mit.edu	37	1	156507028	156507028	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:156507028G>A	uc001fpf.2	-	27	3442	c.3367C>T	c.(3367-3369)CTC>TTC	p.L1123F		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1123	Ras-GAP.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTCATGGCGAGGAGGTTGCGT	0.552													43	32	---	---	---	---	PASS
CD1D	912	broad.mit.edu	37	1	158151308	158151308	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:158151308C>A	uc001frr.2	+	3	624	c.125C>A	c.(124-126)ACG>AAG	p.T42K	CD1D_uc009wsr.1_Missense_Mutation_p.T42K|CD1D_uc009wss.2_Missense_Mutation_p.T42K|CD1D_uc009wst.1_5'UTR	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	42	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					AGCAGCTGGACGCGCACCGAC	0.632													95	84	---	---	---	---	PASS
SPTA1	6708	broad.mit.edu	37	1	158609467	158609467	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:158609467A>G	uc001fst.1	-	35	5084	c.4885T>C	c.(4885-4887)TTG>CTG	p.L1629L		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1629	Spectrin 16.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					ATGGCCAGCAATGTCTCTGCC	0.468													27	62	---	---	---	---	PASS
RGS5	8490	broad.mit.edu	37	1	163138133	163138133	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:163138133C>A	uc001gcn.2	-	2	317	c.70G>T	c.(70-72)GGA>TGA	p.G24*	RGS5_uc009wvb.2_Intron	NM_003617	NP_003608	O15539	RGS5_HUMAN	regulator of G-protein signalling 5	24					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity				0			LUSC - Lung squamous cell carcinoma(543;0.187)			AGGAGAATTCCCAACTTGATC	0.448													6	132	---	---	---	---	PASS
FMO4	2329	broad.mit.edu	37	1	171303694	171303694	+	Silent	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:171303694G>C	uc001gho.2	+	8	1189	c.972G>C	c.(970-972)GTG>GTC	p.V324V		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	324					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TTGATGTTGTGATCTTCACTA	0.373													8	98	---	---	---	---	PASS
FMO4	2329	broad.mit.edu	37	1	171303698	171303698	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:171303698T>G	uc001gho.2	+	8	1193	c.976T>G	c.(976-978)TTC>GTC	p.F326V		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	326					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGTTGTGATCTTCACTACAGG	0.363													7	96	---	---	---	---	PASS
RFWD2	64326	broad.mit.edu	37	1	176012899	176012899	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:176012899C>A	uc001gku.1	-	13	1733	c.1477G>T	c.(1477-1479)GGC>TGC	p.G493C	RFWD2_uc001gkv.1_Missense_Mutation_p.G469C|RFWD2_uc001gkw.1_Missense_Mutation_p.G253C|RFWD2_uc009wwv.2_Missense_Mutation_p.G292C|RFWD2_uc001gkt.1_Missense_Mutation_p.G332C	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	493	WD 2.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						ATAACAGTGCCTTCATAATCA	0.328													7	192	---	---	---	---	PASS
RASAL2	9462	broad.mit.edu	37	1	178425846	178425846	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:178425846C>A	uc001glr.2	+	11	1904	c.1779C>A	c.(1777-1779)TCC>TCA	p.S593S	RASAL2_uc001glq.2_Intron|RASAL2_uc009wxc.2_Silent_p.S107S	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	593					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						GTGAAAATTCCTTCCTACAGG	0.468													9	336	---	---	---	---	PASS
IVNS1ABP	10625	broad.mit.edu	37	1	185270621	185270621	+	Silent	SNP	A	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:185270621A>C	uc001grl.2	-	9	1463	c.840T>G	c.(838-840)GCT>GCG	p.A280A	IVNS1ABP_uc001gri.2_5'UTR|IVNS1ABP_uc001grj.2_5'UTR|IVNS1ABP_uc009wyj.2_Silent_p.A62A|IVNS1ABP_uc009wyk.2_RNA|IVNS1ABP_uc001grm.2_5'UTR	NM_006469	NP_006460	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	280	Sufficient for AHR interaction and signaling.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				ovary(4)|central_nervous_system(1)	5						TTTGTACTGTAGCATTTGGAG	0.398													37	69	---	---	---	---	PASS
FAM5C	339479	broad.mit.edu	37	1	190195245	190195245	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:190195245A>T	uc001gse.1	-	6	1160	c.928T>A	c.(928-930)TGG>AGG	p.W310R	FAM5C_uc010pot.1_Missense_Mutation_p.W208R	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	310						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					TAAGCTTTCCAGGTTTCAGTT	0.368													22	18	---	---	---	---	PASS
CHIT1	1118	broad.mit.edu	37	1	203191413	203191413	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:203191413C>A	uc001gzn.2	-	7	742	c.646G>T	c.(646-648)GGC>TGC	p.G216C	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_Missense_Mutation_p.G7C|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.G207C	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	216					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						TCCCAAGAGCCATGGAAGTCG	0.562													13	25	---	---	---	---	PASS
LAX1	54900	broad.mit.edu	37	1	203740494	203740494	+	Splice_Site	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:203740494G>T	uc001haa.2	+	3	610	c.200_splice	c.e3-1	p.R67_splice	LAX1_uc010pql.1_Splice_Site_p.R51_splice|LAX1_uc001hab.2_Splice_Site	NM_017773	NP_060243	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1 isoform a						B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)	2	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TTGCCTTGCAGGACAAGTTCC	0.507													7	284	---	---	---	---	PASS
USH2A	7399	broad.mit.edu	37	1	216262403	216262403	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:216262403T>C	uc001hku.1	-	23	5224	c.4837A>G	c.(4837-4839)ATT>GTT	p.I1613V		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1613	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGATGCCTAATAGCAATTATT	0.368										HNSCC(13;0.011)			9	104	---	---	---	---	PASS
EPRS	2058	broad.mit.edu	37	1	220179558	220179558	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:220179558T>C	uc001hly.1	-	15	2110	c.1840A>G	c.(1840-1842)ACA>GCA	p.T614A	EPRS_uc010puf.1_Missense_Mutation_p.T365A|EPRS_uc001hlz.1_Missense_Mutation_p.T621A|EPRS_uc009xdt.1_Intron	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	614	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AGAGCATGTGTAGTCTCTGCA	0.388													23	69	---	---	---	---	PASS
MIA3	375056	broad.mit.edu	37	1	222835412	222835412	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:222835412C>A	uc001hnl.2	+	25	5137	c.5128C>A	c.(5128-5130)CCT>ACT	p.P1710T	MIA3_uc001hnm.2_Missense_Mutation_p.P588T	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1710	Pro-rich.|Cytoplasmic (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		AGTGGACGGGCCTCTACCTCA	0.433													11	59	---	---	---	---	PASS
SUSD4	55061	broad.mit.edu	37	1	223396739	223396739	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:223396739G>T	uc001hnx.2	-	7	1930	c.1296C>A	c.(1294-1296)AGC>AGA	p.S432R	SUSD4_uc001hny.3_Missense_Mutation_p.S432R|SUSD4_uc010puw.1_Missense_Mutation_p.S272R	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	432	Cytoplasmic (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)		AGCCTGAGACGCTGTCACAGG	0.617													22	15	---	---	---	---	PASS
RYR2	6262	broad.mit.edu	37	1	237991683	237991683	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:237991683C>T	uc001hyl.1	+	102	14713	c.14593C>T	c.(14593-14595)CTA>TTA	p.L4865L	RYR2_uc010pyb.1_Silent_p.L298L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4865	Helical; Name=M10; (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AACACCAGGTCTAATTATTGA	0.388													5	14	---	---	---	---	PASS
RGS7	6000	broad.mit.edu	37	1	241031891	241031891	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:241031891G>C	uc001hyv.2	-	9	935	c.605C>G	c.(604-606)CCC>CGC	p.P202R	RGS7_uc010pyh.1_Missense_Mutation_p.P176R|RGS7_uc010pyj.1_Missense_Mutation_p.P118R|RGS7_uc001hyu.2_Missense_Mutation_p.P202R|RGS7_uc009xgn.1_Missense_Mutation_p.P149R|RGS7_uc001hyw.2_Missense_Mutation_p.P202R|RGS7_uc001hyt.2_Missense_Mutation_p.P34R	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	202					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GCTTACCACGGGCCTGTGCAC	0.507													9	135	---	---	---	---	PASS
CNST	163882	broad.mit.edu	37	1	246784903	246784903	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:246784903G>T	uc001ibp.2	+	3	930	c.552G>T	c.(550-552)TTG>TTT	p.L184F	CNST_uc001ibo.3_Missense_Mutation_p.L184F	NM_152609	NP_689822	Q6PJW8	CNST_HUMAN	hypothetical protein LOC163882 isoform 1	184					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding				0						TTGAGCAGTTGGATTCAAGAG	0.453													8	303	---	---	---	---	PASS
NLRP3	114548	broad.mit.edu	37	1	247607428	247607428	+	Nonsense_Mutation	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:247607428A>T	uc001icr.2	+	9	2962	c.2824A>T	c.(2824-2826)AAG>TAG	p.K942*	NLRP3_uc001ics.2_Nonsense_Mutation_p.K885*|NLRP3_uc001icu.2_Nonsense_Mutation_p.K942*|NLRP3_uc001icw.2_Nonsense_Mutation_p.K885*|NLRP3_uc001icv.2_Nonsense_Mutation_p.K828*|NLRP3_uc010pyw.1_Nonsense_Mutation_p.K920*	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	942	LRR 8.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding	p.K942N(1)		lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CCCCGACTGCAAGCTTCAGGT	0.507													37	59	---	---	---	---	PASS
OR2T4	127074	broad.mit.edu	37	1	248525863	248525863	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:248525863G>T	uc001ieh.1	+	1	981	c.981G>T	c.(979-981)AAG>AAT	p.K327N		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	327	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTAGGAATAAGGATGTCATGG	0.428													77	92	---	---	---	---	PASS
SNTG2	54221	broad.mit.edu	37	2	1263159	1263159	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:1263159G>T	uc002qwq.2	+	13	1151	c.1023G>T	c.(1021-1023)TGG>TGT	p.W341C	SNTG2_uc010ewi.2_Missense_Mutation_p.W214C	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	341	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CATTCGATTGGGTGCGAGCAG	0.393													5	72	---	---	---	---	PASS
TTC15	51112	broad.mit.edu	37	2	3392340	3392340	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:3392340A>G	uc002qxm.1	+	2	1152	c.946A>G	c.(946-948)ACG>GCG	p.T316A	TTC15_uc002qxn.1_Missense_Mutation_p.T316A|TTC15_uc010ewm.1_Missense_Mutation_p.T316A|TTC15_uc002qxl.1_Missense_Mutation_p.T316A	NM_016030	NP_057114	Q8WVT3	TTC15_HUMAN	tetratricopeptide repeat domain 15	316							binding			ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.214)		OV - Ovarian serous cystadenocarcinoma(76;0.0402)|Epithelial(75;0.0986)|all cancers(51;0.149)		CGGCGAGGCTACGCGTGGAGT	0.662													3	4	---	---	---	---	PASS
NBAS	51594	broad.mit.edu	37	2	15378795	15378795	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:15378795G>A	uc002rcc.1	-	45	5766	c.5740C>T	c.(5740-5742)CGT>TGT	p.R1914C	NBAS_uc002rcb.1_5'UTR|NBAS_uc010exl.1_Missense_Mutation_p.R986C|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1914										ovary(2)|liver(1)|skin(1)	4						ATCTCTTTACGGGCTTCCACA	0.368													7	28	---	---	---	---	PASS
SMC6	79677	broad.mit.edu	37	2	17896303	17896303	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:17896303G>A	uc002rco.2	-	16	1851	c.1555C>T	c.(1555-1557)CTT>TTT	p.L519F	SMC6_uc010exo.2_Missense_Mutation_p.L519F|SMC6_uc002rcn.2_Missense_Mutation_p.L519F|SMC6_uc002rcp.1_Missense_Mutation_p.L545F|SMC6_uc002rcq.2_Missense_Mutation_p.L545F	NM_001142286	NP_001135758	Q96SB8	SMC6_HUMAN	SMC6 protein	519	Flexible hinge.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			breast(4)|upper_aerodigestive_tract(1)|kidney(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GCCAAAGCAAGTTCTGGGTCC	0.393													67	55	---	---	---	---	PASS
APOB	338	broad.mit.edu	37	2	21227276	21227276	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:21227276G>A	uc002red.2	-	28	12080	c.11952C>T	c.(11950-11952)ACC>ACT	p.T3984T		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3984					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATGGAGATCGGTGAACGCTG	0.512													10	62	---	---	---	---	PASS
RAB10	10890	broad.mit.edu	37	2	26257592	26257592	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:26257592A>T	uc002rgv.2	+	1	864	c.115A>T	c.(115-117)ATT>TTT	p.I39F		NM_016131	NP_057215	P61026	RAB10_HUMAN	ras-related GTP-binding protein RAB10	39	Effector region (By similarity).				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACTACCTTTATTTCCACCAT	0.493													18	97	---	---	---	---	PASS
SLC30A3	7781	broad.mit.edu	37	2	27481650	27481650	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:27481650C>A	uc002rjk.2	-	2	434	c.248G>T	c.(247-249)TGC>TTC	p.C83F	SLC30A3_uc002rjj.2_5'Flank|SLC30A3_uc010ylh.1_Missense_Mutation_p.C78F	NM_003459	NP_003450	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter),	83	Helical; (Potential).				regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAAGACAAAGCAAACGGCACA	0.612													32	33	---	---	---	---	PASS
FAM179A	165186	broad.mit.edu	37	2	29259412	29259412	+	Silent	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:29259412T>C	uc010ezl.2	+	18	2775	c.2424T>C	c.(2422-2424)TTT>TTC	p.F808F	FAM179A_uc010ymm.1_Silent_p.F753F|FAM179A_uc002rmr.3_Silent_p.F335F|FAM179A_uc002rms.1_Silent_p.F106F	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	808							binding			ovary(3)|skin(1)	4						AATAGGTCTTTGATGCTTTCA	0.552													30	21	---	---	---	---	PASS
C2orf71	388939	broad.mit.edu	37	2	29296932	29296932	+	Silent	SNP	T	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:29296932T>G	uc002rmt.1	-	1	196	c.196A>C	c.(196-198)AGG>CGG	p.R66R		NM_001029883	NP_001025054	A6NGG8	CB071_HUMAN	hypothetical protein LOC388939	66					response to stimulus|visual perception	photoreceptor outer segment				skin(1)	1						GTTTGGTTCCTCCTGGGACTT	0.527													18	32	---	---	---	---	PASS
TTC7A	57217	broad.mit.edu	37	2	47273469	47273469	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:47273469G>T	uc002rvo.2	+	16	2186	c.1818G>T	c.(1816-1818)AAG>AAT	p.K606N	TTC7A_uc002rvm.2_Missense_Mutation_p.K572N|TTC7A_uc002rvn.1_Intron|TTC7A_uc010fbb.2_Missense_Mutation_p.K606N|TTC7A_uc010fbc.2_Missense_Mutation_p.K252N|TTC7A_uc002rvp.2_Missense_Mutation_p.K487N|TTC7A_uc002rvq.2_Missense_Mutation_p.K346N|TTC7A_uc002rvr.2_Missense_Mutation_p.K55N	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	606							binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TGTTCACCAAGGTGAAGCTGG	0.632													4	27	---	---	---	---	PASS
PSME4	23198	broad.mit.edu	37	2	54175569	54175569	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:54175569A>G	uc002rxp.2	-	3	545	c.489T>C	c.(487-489)AAT>AAC	p.N163N	PSME4_uc010yop.1_Silent_p.N49N|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_5'UTR|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	163					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TAGGAAACCAATTTAATCCTA	0.358													13	84	---	---	---	---	PASS
SPTBN1	6711	broad.mit.edu	37	2	54882236	54882236	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:54882236A>G	uc002rxu.2	+	28	6101	c.5852A>G	c.(5851-5853)AAT>AGT	p.N1951S	SPTBN1_uc002rxx.2_Missense_Mutation_p.N1938S|SPTBN1_uc002rxy.2_Missense_Mutation_p.N96S|SPTBN1_uc010you.1_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1951	Spectrin 16.|Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CTCTTAATGAATAATCATCAA	0.373													16	15	---	---	---	---	PASS
AHSA2	130872	broad.mit.edu	37	2	61413610	61413610	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:61413610G>T	uc002sbc.1	+	5	1808	c.222G>T	c.(220-222)TGG>TGT	p.W74C	AHSA2_uc002sbb.1_RNA	NM_152392	NP_689605	Q719I0	AHSA2_HUMAN	AHA1, activator of heat shock 90kDa protein	236					response to stress	cytoplasm	ATPase activator activity|chaperone binding			breast(1)	1			Epithelial(17;0.0994)			TCATGAAATGGAGATGTGGGA	0.358													5	66	---	---	---	---	PASS
GMCL1	64395	broad.mit.edu	37	2	70082087	70082087	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:70082087C>A	uc002sfu.2	+	9	1274	c.1067C>A	c.(1066-1068)CCT>CAT	p.P356H		NM_178439	NP_848526	Q96IK5	GMCL1_HUMAN	germ cell-less	356					cell differentiation|multicellular organismal development|spermatogenesis	nuclear matrix				ovary(3)	3						GCTGTAGTACCTTCAGGTAAG	0.279													6	63	---	---	---	---	PASS
CTNNA2	1496	broad.mit.edu	37	2	80136767	80136767	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:80136767G>A	uc010ysh.1	+	6	905	c.900G>A	c.(898-900)CGG>CGA	p.R300R	CTNNA2_uc010yse.1_Silent_p.R300R|CTNNA2_uc010ysf.1_Silent_p.R300R|CTNNA2_uc010ysg.1_Silent_p.R300R	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	300					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CCAGGTTCCGGCCGTCCCTGG	0.597													6	39	---	---	---	---	PASS
KDM3A	55818	broad.mit.edu	37	2	86683959	86683959	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:86683959T>A	uc002sri.3	+	7	1040	c.713T>A	c.(712-714)CTG>CAG	p.L238Q	KDM3A_uc010ytj.1_Missense_Mutation_p.L238Q|KDM3A_uc010ytk.1_Missense_Mutation_p.L186Q	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	238					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						GATCCGTCACTGATTCATGTT	0.343													17	16	---	---	---	---	PASS
RPIA	22934	broad.mit.edu	37	2	89028822	89028822	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:89028822C>A	uc002ste.2	+	4	470	c.429C>A	c.(427-429)GGC>GGA	p.G143G		NM_144563	NP_653164	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	143					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity	p.G143D(1)		ovary(1)	1		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				TGCAGTATGGCTTGACCCTCA	0.498													4	23	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	89399590	89399590	+	RNA	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:89399590C>A	uc010ytr.1	-	46		c.4855G>T			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		GACTCTGTCTCCTACAGATGC	0.463													84	68	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	89399591	89399591	+	RNA	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:89399591C>T	uc010ytr.1	-	46		c.4854G>A			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		ACTCTGTCTCCTACAGATGCA	0.463													84	68	---	---	---	---	PASS
ADRA2B	151	broad.mit.edu	37	2	96781011	96781011	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:96781011G>A	uc002svi.2	-	1	878	c.878C>T	c.(877-879)CCA>CTA	p.P293L		NM_000682	NP_000673	P18089	ADA2B_HUMAN	alpha-2B-adrenergic receptor	293	Cytoplasmic (By similarity).				activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			ovary(2)|lung(1)	3					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	TTCATCCTCTGGAGATGCCCC	0.557													4	8	---	---	---	---	PASS
SNRNP200	23020	broad.mit.edu	37	2	96952549	96952549	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:96952549G>T	uc002svu.2	-	28	3792	c.3706C>A	c.(3706-3708)CAT>AAT	p.H1236N	SNRNP200_uc002svt.2_5'Flank|SNRNP200_uc010yuj.1_5'Flank|SNRNP200_uc002svv.1_5'Flank|SNRNP200_uc002svw.1_Missense_Mutation_p.H308N	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1236	SEC63 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						AAATACTCATGGTGCAGAATC	0.522													5	81	---	---	---	---	PASS
CNNM3	26505	broad.mit.edu	37	2	97492658	97492658	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:97492658T>G	uc002swy.2	+	3	1482	c.1458T>G	c.(1456-1458)GAT>GAG	p.D486E	CNNM3_uc002swz.2_Missense_Mutation_p.D438E	NM_017623	NP_060093	Q8NE01	CNNM3_HUMAN	cyclin M3 isoform 1	486					ion transport	integral to membrane|plasma membrane	protein binding			ovary(1)	1						TGTCTGATGATGAATATAAAG	0.562													9	58	---	---	---	---	PASS
CHST10	9486	broad.mit.edu	37	2	101010038	101010038	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:101010038G>A	uc002tam.2	-	7	1099	c.740C>T	c.(739-741)CCG>CTG	p.P247L		NM_004854	NP_004845	O43529	CHSTA_HUMAN	HNK-1 sulfotransferase	247	Lumenal (Potential).				carbohydrate biosynthetic process|cell adhesion	Golgi membrane|integral to membrane|membrane fraction				ovary(1)	1						TCTGTGGTTCGGATCGCCGAG	0.512													19	137	---	---	---	---	PASS
LIMS1	3987	broad.mit.edu	37	2	109300362	109300362	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:109300362C>G	uc002teg.2	+	10	1004	c.885C>G	c.(883-885)GAC>GAG	p.D295E	LIMS1_uc002tef.2_Missense_Mutation_p.D307E|LIMS1_uc002teh.2_Missense_Mutation_p.D295E|LIMS1_uc002tei.2_Missense_Mutation_p.D295E|LIMS1_uc002tej.2_Missense_Mutation_p.D332E|LIMS1_uc002tek.3_Missense_Mutation_p.D357E|uc002tel.2_5'Flank	NM_004987	NP_004978	P48059	LIMS1_HUMAN	LIM and senescent cell antigen-like domains 1	295	LIM zinc-binding 5.				cell aging|cell junction assembly|cellular response to transforming growth factor beta stimulus|negative regulation of transcription, DNA-dependent	cytosol|focal adhesion|perinuclear region of cytoplasm	protein binding|zinc ion binding				0						TGGAGTTTGACATGAAGCCAG	0.313													7	34	---	---	---	---	PASS
TUBA3E	112714	broad.mit.edu	37	2	130953819	130953819	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:130953819A>G	uc002tqv.2	-	2	230	c.129T>C	c.(127-129)GGT>GGC	p.G43G		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	43					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					CGTCCCCGCCACCAATGGTTT	0.562													13	72	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141771263	141771263	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:141771263C>A	uc002tvj.1	-	14	3214	c.2242G>T	c.(2242-2244)GGA>TGA	p.G748*	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	748	Extracellular (Potential).|LDL-receptor class B 8.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACATAATTTCCATGATGCGAC	0.383										TSP Lung(27;0.18)			5	61	---	---	---	---	PASS
UPP2	151531	broad.mit.edu	37	2	158974404	158974404	+	Silent	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:158974404G>C	uc002tzp.2	+	4	602	c.408G>C	c.(406-408)CGG>CGC	p.R136R	UPP2_uc002tzo.2_Silent_p.R193R	NM_173355	NP_775491	O95045	UPP2_HUMAN	uridine phosphorylase 2 isoform a	136					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity				0						ACCATGCACGGTGCTGCGATG	0.428													15	105	---	---	---	---	PASS
FAP	2191	broad.mit.edu	37	2	163082006	163082006	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:163082006C>A	uc002ucd.2	-	4	480	c.272G>T	c.(271-273)AGT>ATT	p.S91I	FAP_uc010zct.1_Missense_Mutation_p.S91I|FAP_uc010fpd.2_Intron|FAP_uc010fpe.1_Missense_Mutation_p.S58I	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	91	Extracellular (Potential).				endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						GGTTCTATTACTCAAAATGGT	0.343													8	37	---	---	---	---	PASS
GCA	25801	broad.mit.edu	37	2	163212953	163212953	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:163212953A>T	uc002ucg.2	+	4	444	c.268A>T	c.(268-270)AGT>TGT	p.S90C	GCA_uc010zcu.1_Missense_Mutation_p.S71C	NM_012198	NP_036330	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	90	EF-hand 2.				cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity				0						TACAGCCTTCAGTTTGGAAAC	0.284													36	14	---	---	---	---	PASS
SCN1A	6323	broad.mit.edu	37	2	166892733	166892733	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:166892733C>A	uc010zcz.1	-	16	3239	c.3221G>T	c.(3220-3222)GGT>GTT	p.G1074V	SCN1A_uc002udo.3_Missense_Mutation_p.G954V|SCN1A_uc010fpk.2_Missense_Mutation_p.G926V	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1085						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AGTTCCTATACCACTTGTAGT	0.353													36	16	---	---	---	---	PASS
NFE2L2	4780	broad.mit.edu	37	2	178098945	178098945	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:178098945G>C	uc002ulh.3	-	2	655	c.100C>G	c.(100-102)CGA>GGA	p.R34G	NFE2L2_uc002ulg.3_Missense_Mutation_p.R18G|NFE2L2_uc010zfa.1_Missense_Mutation_p.R18G|NFE2L2_uc002uli.3_Missense_Mutation_p.R18G|NFE2L2_uc010fra.2_Missense_Mutation_p.R18G|NFE2L2_uc010frb.2_Missense_Mutation_p.R18G	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	34					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AATACTTCTCGACTTACTCCA	0.368			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			23	15	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179592919	179592919	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:179592919T>G	uc010zfg.1	-	64	16124	c.15900A>C	c.(15898-15900)GAA>GAC	p.E5300D	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E1961D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6227							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATCTTCTAATTCCAGATTAT	0.378													11	29	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179610662	179610662	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:179610662T>G	uc002unb.2	-	46	16689	c.16465A>C	c.(16465-16467)AGT>CGT	p.S5489R	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCATTAAACTGCTTAAAGTC	0.403													30	69	---	---	---	---	PASS
ZC3H15	55854	broad.mit.edu	37	2	187368929	187368929	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:187368929A>G	uc002upo.2	+	6	930	c.705A>G	c.(703-705)CTA>CTG	p.L235L		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	erythropoietin 4 immediate early response	235	Potential.					cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			TAGAAGATCTAATTGAGAGAG	0.333													35	24	---	---	---	---	PASS
HSPD1	3329	broad.mit.edu	37	2	198358104	198358104	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:198358104C>A	uc002uui.2	-	7	950	c.813G>T	c.(811-813)TTG>TTT	p.L271F	HSPD1_uc002uuj.2_Missense_Mutation_p.L269F|HSPD1_uc010zgx.1_Missense_Mutation_p.L262F|HSPD1_uc010fsm.2_Missense_Mutation_p.L82F|HSPD1_uc002uuk.2_Missense_Mutation_p.L271F	NM_002156	NP_002147	P10809	CH60_HUMAN	chaperonin	271					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding				0			Epithelial(96;0.225)			CGATTATGACCAAAGGCTTAC	0.388													5	96	---	---	---	---	PASS
NDUFS1	4719	broad.mit.edu	37	2	207011634	207011634	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:207011634C>T	uc002vbe.2	-	8	857	c.730G>A	c.(730-732)GAA>AAA	p.E244K	NDUFS1_uc010ziq.1_Missense_Mutation_p.E258K|NDUFS1_uc010zir.1_Missense_Mutation_p.E208K|NDUFS1_uc010zis.1_Missense_Mutation_p.E187K|NDUFS1_uc010zit.1_Missense_Mutation_p.E133K|NDUFS1_uc010ziu.1_Missense_Mutation_p.E128K	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	244					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	TACCTTGTTTCCCAAGGCCGG	0.363													10	59	---	---	---	---	PASS
CCDC108	255101	broad.mit.edu	37	2	219895545	219895545	+	Nonsense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:219895545G>A	uc002vjl.1	-	9	1111	c.1027C>T	c.(1027-1029)CAG>TAG	p.Q343*	CCDC108_uc010fwa.1_5'Flank|CCDC108_uc010zkp.1_Nonsense_Mutation_p.Q332*|CCDC108_uc010zkq.1_Nonsense_Mutation_p.Q278*	NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	343						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACCAGCAGCTGGGCGCACTTG	0.637													14	20	---	---	---	---	PASS
PAX3	5077	broad.mit.edu	37	2	223085966	223085966	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:223085966A>G	uc010fwo.2	-	6	1299	c.933T>C	c.(931-933)TCT>TCC	p.S311S	PAX3_uc002vmt.1_Silent_p.S311S|PAX3_uc002vmy.1_Silent_p.S310S|PAX3_uc002vmv.1_Silent_p.S311S|PAX3_uc002vmw.1_Silent_p.S311S|PAX3_uc002vmx.1_Silent_p.S311S	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	311					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGGCTGGTAAGAGGTCTCCG	0.507			T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						59	144	---	---	---	---	PASS
DOCK10	55619	broad.mit.edu	37	2	225638050	225638050	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:225638050G>C	uc010fwz.1	-	53	6267	c.6028C>G	c.(6028-6030)CCC>GCC	p.P2010A	DOCK10_uc002vob.2_Missense_Mutation_p.P2004A|DOCK10_uc002voa.2_Missense_Mutation_p.P666A	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	2010	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TTCACGTAGGGGAACAGGTGA	0.438													28	22	---	---	---	---	PASS
SPHKAP	80309	broad.mit.edu	37	2	228846483	228846483	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr2:228846483G>T	uc002vpq.2	-	12	5100	c.5053C>A	c.(5053-5055)CAG>AAG	p.Q1685K	SPHKAP_uc002vpp.2_Missense_Mutation_p.Q1656K|SPHKAP_uc010zlx.1_3'UTR	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1685						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CCATCCTTCTGCTCCTCATGC	0.448													15	27	---	---	---	---	PASS
SYN2	6854	broad.mit.edu	37	3	12187261	12187261	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:12187261G>T	uc003bwm.2	+	8	774	c.610G>T	c.(610-612)GGT>TGT	p.G204C	SYN2_uc003bwl.1_Missense_Mutation_p.G204C	NM_133625	NP_598328	Q92777	SYN2_HUMAN	synapsin II isoform IIa	204					neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			ovary(1)|central_nervous_system(1)	2						CCTGATCATTGGTATGCAGTA	0.557													6	62	---	---	---	---	PASS
AZI2	64343	broad.mit.edu	37	3	28379458	28379458	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:28379458G>T	uc003ceb.2	-	4	941	c.409C>A	c.(409-411)CAG>AAG	p.Q137K	AZI2_uc003cec.2_Missense_Mutation_p.Q25K|AZI2_uc003ced.2_Missense_Mutation_p.Q137K|AZI2_uc003cee.3_Missense_Mutation_p.Q137K|AZI2_uc003ceg.2_Missense_Mutation_p.Q137K|AZI2_uc011axd.1_Missense_Mutation_p.Q137K|AZI2_uc003cef.2_Missense_Mutation_p.Q137K	NM_022461	NP_071906	Q9H6S1	AZI2_HUMAN	5-azacytidine induced 2 isoform a	137	Potential.					mitochondrion|plasma membrane				ovary(2)	2						GTCCTCAGCTGGAGGAGTTCT	0.333													4	21	---	---	---	---	PASS
OSBPL10	114884	broad.mit.edu	37	3	31725157	31725157	+	Silent	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:31725157G>C	uc003cev.2	-	9	2076	c.1695C>G	c.(1693-1695)GGC>GGG	p.G565G	OSBPL10_uc003ceu.1_Silent_p.G322G|OSBPL10_uc011axf.1_Silent_p.G501G	NM_017784	NP_060254	Q9BXB5	OSB10_HUMAN	oxysterol-binding protein-like protein 10	565					lipid transport		lipid binding			skin(1)	1				STAD - Stomach adenocarcinoma(1;0.00406)		CCACGGACATGCCCATGAACT	0.488													44	12	---	---	---	---	PASS
TRANK1	9881	broad.mit.edu	37	3	36872547	36872547	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:36872547C>A	uc003cgj.2	-	12	7047	c.6745G>T	c.(6745-6747)GAG>TAG	p.E2249*		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2799					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						TCCACCTTCTCGTGGAAAAAT	0.532													4	101	---	---	---	---	PASS
OXSR1	9943	broad.mit.edu	37	3	38263138	38263138	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:38263138T>C	uc003chy.2	+	6	902	c.560T>C	c.(559-561)GTT>GCT	p.V187A	OXSR1_uc010hhb.2_Missense_Mutation_p.V121A|OXSR1_uc010hha.1_Missense_Mutation_p.V119A	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	187	Protein kinase.				intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		AAGACCTTTGTTGGCACCCCT	0.383													16	63	---	---	---	---	PASS
SCN11A	11280	broad.mit.edu	37	3	38888793	38888793	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:38888793T>C	uc011ays.1	-	26	4967	c.4768A>G	c.(4768-4770)ATC>GTC	p.I1590V		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1590	IV.|Helical; Name=S6 of repeat IV; (By similarity).				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AGAAAGGAGATGATAATGTAA	0.433													11	36	---	---	---	---	PASS
MIR135A1	406925	broad.mit.edu	37	3	52328291	52328291	+	RNA	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:52328291T>A	hsa-mir-135a-1|MI0000452	-			c.34T>A			GLYCTK_uc003ddm.2_RNA|GLYCTK_uc003ddo.2_3'UTR|GLYCTK_uc003ddn.2_RNA|GLYCTK_uc003ddr.2_3'UTR|uc010hmf.2_RNA																	0						TAGAATCACATAGGAATAAAA	0.597													7	44	---	---	---	---	PASS
KBTBD8	84541	broad.mit.edu	37	3	67054263	67054263	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:67054263T>G	uc003dmy.2	+	3	925	c.872T>G	c.(871-873)TTT>TGT	p.F291C	KBTBD8_uc011bfv.1_Intron	NM_032505	NP_115894	Q8NFY9	KBTB8_HUMAN	T-cell activation kelch repeat protein	291										ovary(2)|large_intestine(1)|breast(1)	4		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		ATCATATGTTTTGATGCTGCC	0.443													17	54	---	---	---	---	PASS
ROBO1	6091	broad.mit.edu	37	3	79174687	79174687	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:79174687G>T	uc003dqe.2	-	3	299	c.91C>A	c.(91-93)CCT>ACT	p.P31T		NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	31	Extracellular (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ACATCTTCAGGGTCTGTCGGA	0.502													10	7	---	---	---	---	PASS
ZNF654	55279	broad.mit.edu	37	3	88190171	88190171	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:88190171C>G	uc003dqv.2	+	1	1910	c.1711C>G	c.(1711-1713)CTC>GTC	p.L571V	CGGBP1_uc003dqu.2_5'UTR	NM_018293	NP_060763	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	571					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		ATGTCAGACACTCTTTGGATT	0.348													8	26	---	---	---	---	PASS
KIAA1524	57650	broad.mit.edu	37	3	108300321	108300321	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:108300321C>A	uc003dxb.3	-	5	759	c.490G>T	c.(490-492)GGA>TGA	p.G164*	KIAA1524_uc003dxc.1_Nonsense_Mutation_p.G5*|KIAA1524_uc010hpw.1_Nonsense_Mutation_p.G5*	NM_020890	NP_065941	Q8TCG1	CIP2A_HUMAN	p90 autoantigen	164						cytoplasm|integral to membrane	protein binding			ovary(2)|central_nervous_system(1)	3						GCCAATAATCCTAGACAAGGC	0.289													16	23	---	---	---	---	PASS
POPDC2	64091	broad.mit.edu	37	3	119367422	119367422	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:119367422G>A	uc003ecx.1	-	3	828	c.694C>T	c.(694-696)CTC>TTC	p.L232F	POPDC2_uc010hqw.1_Missense_Mutation_p.L232F|POPDC2_uc003ecy.1_Missense_Mutation_p.L50F	NM_022135	NP_071418	Q9HBU9	POPD2_HUMAN	popeye protein 2	232						integral to membrane				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(114;0.242)		GCCGAGAAGAGGCAGGAGATG	0.507													8	37	---	---	---	---	PASS
GOLGB1	2804	broad.mit.edu	37	3	121417220	121417220	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:121417220T>C	uc003eei.3	-	13	2261	c.2135A>G	c.(2134-2136)GAT>GGT	p.D712G	GOLGB1_uc010hrc.2_Missense_Mutation_p.D717G|GOLGB1_uc003eej.3_Missense_Mutation_p.D678G|GOLGB1_uc011bjm.1_Missense_Mutation_p.D598G|GOLGB1_uc010hrd.1_Missense_Mutation_p.D676G	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	712	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		AGCTTTCTCATCTAAATTTTT	0.363													18	25	---	---	---	---	PASS
MYLK	4638	broad.mit.edu	37	3	123382998	123382998	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:123382998C>T	uc003ego.2	-	23	4221	c.3939G>A	c.(3937-3939)GAG>GAA	p.E1313E	MYLK_uc010hrr.2_5'UTR|MYLK_uc011bjv.1_Silent_p.E113E|MYLK_uc011bjw.1_Silent_p.E1313E|MYLK_uc003egp.2_Silent_p.E1244E|MYLK_uc003egq.2_Silent_p.E1313E|MYLK_uc003egr.2_Silent_p.E1244E|MYLK_uc003egs.2_Silent_p.E1137E	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	1313	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 8.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCAGCTTGTTCTCCACCAGCA	0.632													12	60	---	---	---	---	PASS
EEFSEC	60678	broad.mit.edu	37	3	128060451	128060451	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:128060451G>A	uc003eki.2	+	5	1200	c.1162G>A	c.(1162-1164)GTG>ATG	p.V388M	EEFSEC_uc003ekj.2_Missense_Mutation_p.V333M	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	388						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						GACACCAGCAGTGACAGACAA	0.537													9	18	---	---	---	---	PASS
CLSTN2	64084	broad.mit.edu	37	3	140281693	140281693	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:140281693C>T	uc003etn.2	+	14	2443	c.2253C>T	c.(2251-2253)CAC>CAT	p.H751H		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	751	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						TGCTACATCACATCCGCTACC	0.552										HNSCC(16;0.037)			5	21	---	---	---	---	PASS
PAQR9	344838	broad.mit.edu	37	3	142681705	142681705	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:142681705G>A	uc003evg.2	-	1	474	c.474C>T	c.(472-474)TAC>TAT	p.Y158Y	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	158	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						TGATGGACGCGTAGTCCAGGT	0.612													6	14	---	---	---	---	PASS
CPA3	1359	broad.mit.edu	37	3	148614379	148614379	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:148614379G>T	uc003ewm.2	+	11	1191	c.1139G>T	c.(1138-1140)CGA>CTA	p.R380L		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	380					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TTTGAGCTCCGAGATAAAGGC	0.418													4	76	---	---	---	---	PASS
GFM1	85476	broad.mit.edu	37	3	158363992	158363992	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:158363992C>A	uc003fce.2	+	3	380	c.273C>A	c.(271-273)TCC>TCA	p.S91S	GFM1_uc003fcd.2_Silent_p.S91S|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_Silent_p.S3S	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	91					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			TCATGGATTCCATGGAACTAG	0.413													5	76	---	---	---	---	PASS
SERPINI2	5276	broad.mit.edu	37	3	167184891	167184891	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:167184891T>C	uc003fer.1	-	2	488	c.430A>G	c.(430-432)AAG>GAG	p.K144E	SERPINI2_uc003fes.1_Missense_Mutation_p.K154E|SERPINI2_uc003fet.1_Missense_Mutation_p.K144E	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	144					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						GCACAAGCCTTTGCATCTTGA	0.358													9	46	---	---	---	---	PASS
DCUN1D1	54165	broad.mit.edu	37	3	182679132	182679132	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:182679132T>C	uc003fld.1	-	4	451	c.402A>G	c.(400-402)ATA>ATG	p.I134M	DCUN1D1_uc011bqn.1_Translation_Start_Site	NM_020640	NP_065691	Q96GG9	DCNL1_HUMAN	RP42 homolog	134	DCUN1.			I -> T (in Ref. 2; AAL78673).		ubiquitin ligase complex	protein binding			ovary(1)	1	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			TTAGTTTTTCTATGCTGTCAC	0.308													105	350	---	---	---	---	PASS
EPHB3	2049	broad.mit.edu	37	3	184298901	184298901	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:184298901A>G	uc003foz.2	+	14	3117	c.2680A>G	c.(2680-2682)AAG>GAG	p.K894E		NM_004443	NP_004434	P54753	EPHB3_HUMAN	ephrin receptor EphB3 precursor	894	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(5)|breast(2)|upper_aerodigestive_tract(1)|stomach(1)|skin(1)|ovary(1)	11	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TACCCTGGACAAGCTCATCCG	0.592													43	117	---	---	---	---	PASS
VPS8	23355	broad.mit.edu	37	3	184612617	184612617	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:184612617G>T	uc003fpb.1	+	22	2073	c.1902G>T	c.(1900-1902)ATG>ATT	p.M634I	VPS8_uc010hyd.1_Intron|VPS8_uc010hye.1_Missense_Mutation_p.M63I	NM_015303	NP_056118	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog isoform b	636							zinc ion binding			ovary(1)	1	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			CCCAAGTAATGAAAGACTTGA	0.358													13	32	---	---	---	---	PASS
ZDHHC19	131540	broad.mit.edu	37	3	195937539	195937539	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:195937539G>T	uc003fwc.2	-	2	330	c.216C>A	c.(214-216)ACC>ACA	p.T72T	ZDHHC19_uc010hzz.2_RNA|ZDHHC19_uc010iaa.2_Intron|ZDHHC19_uc010iab.2_RNA	NM_001039617	NP_001034706	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC domain containing 19	72	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			ovary(3)	3	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)		GACTGAAGAAGGTAAGGACAA	0.557													5	47	---	---	---	---	PASS
SLC34A2	10568	broad.mit.edu	37	4	25677955	25677955	+	Missense_Mutation	SNP	C	T	T	rs115500754	by1000genomes	TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:25677955C>T	uc003grr.2	+	13	1738	c.1657C>T	c.(1657-1659)CGG>TGG	p.R553W	SLC34A2_uc003grs.2_Missense_Mutation_p.R552W|SLC34A2_uc010iev.2_Missense_Mutation_p.R552W	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	553	Helical; Name=M8; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				GGCCGGCTGGCGGGTGCTGGT	0.597													13	38	---	---	---	---	PASS
ARAP2	116984	broad.mit.edu	37	4	36093640	36093640	+	Missense_Mutation	SNP	G	A	A	rs143499964		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:36093640G>A	uc003gsq.1	-	28	4626	c.4288C>T	c.(4288-4290)CGG>TGG	p.R1430W		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1430					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AGTGTACTCCGGTCTGTAAAG	0.308													14	37	---	---	---	---	PASS
WDR19	57728	broad.mit.edu	37	4	39241945	39241945	+	Silent	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:39241945T>C	uc003gtv.2	+	21	2566	c.2412T>C	c.(2410-2412)GGT>GGC	p.G804G	WDR19_uc011byi.1_Silent_p.G644G|WDR19_uc003gtw.1_Silent_p.G401G	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	804	TPR 2.				cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						GAATAACAGGTGATAATAAGG	0.249													5	2	---	---	---	---	PASS
PDS5A	23244	broad.mit.edu	37	4	39878748	39878748	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:39878748G>T	uc003guv.3	-	19	2558	c.2018C>A	c.(2017-2019)TCG>TAG	p.S673*	PDS5A_uc010ifo.2_Nonsense_Mutation_p.S633*	NM_001100399	NP_001093869	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog	673					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding				0						AGAGTGGAACGAGGTAGGATG	0.373													5	191	---	---	---	---	PASS
RHOH	399	broad.mit.edu	37	4	40245213	40245213	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:40245213G>A	uc003guz.2	+	3	931	c.207G>A	c.(205-207)CGG>CGA	p.R69R		NM_004310	NP_004301	Q15669	RHOH_HUMAN	ras homolog gene family, member H precursor	69					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			ovary(1)|lung(1)	2						GAAGCATCCGGCCCCTGTCCT	0.542													8	46	---	---	---	---	PASS
GRXCR1	389207	broad.mit.edu	37	4	42965024	42965024	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:42965024G>A	uc003gwt.2	+	2	500	c.500G>A	c.(499-501)CGC>CAC	p.R167H		NM_001080476	NP_001073945	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	167	Glutaredoxin.				cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			ovary(1)	1						CAAAACCATCGCGTAAAATTT	0.428													68	233	---	---	---	---	PASS
GABRA2	2555	broad.mit.edu	37	4	46307592	46307592	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:46307592G>T	uc003gxc.3	-	6	1369	c.696C>A	c.(694-696)TCC>TCA	p.S232S	GABRA2_uc010igc.2_Silent_p.S232S|GABRA2_uc011bzc.1_Silent_p.S177S|GABRA2_uc003gxe.2_Silent_p.S232S	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	232	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AACCTGTACTGGATTTAATTG	0.373													5	94	---	---	---	---	PASS
LPHN3	23284	broad.mit.edu	37	4	62542559	62542559	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:62542559C>A	uc010ihh.2	+	3	458	c.285C>A	c.(283-285)ACC>ACA	p.T95T	LPHN3_uc003hcq.3_Silent_p.T95T|LPHN3_uc010ihg.1_Silent_p.T163T	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	95	SUEL-type lectin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ATAACAGAACCCAGTGTGCAG	0.373													54	105	---	---	---	---	PASS
TMPRSS11B	132724	broad.mit.edu	37	4	69100335	69100335	+	Missense_Mutation	SNP	A	T	T	rs138592272		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:69100335A>T	uc003hdw.3	-	5	451	c.315T>A	c.(313-315)AAT>AAA	p.N105K		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	105	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AACCATTGGCATTAGGCCTAG	0.333													26	23	---	---	---	---	PASS
SDAD1	55153	broad.mit.edu	37	4	76911921	76911921	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:76911921G>C	uc003hje.3	-	1	193	c.74C>G	c.(73-75)CCG>CGG	p.P25R	SDAD1_uc003hjf.3_5'UTR|SDAD1_uc011cbr.1_Missense_Mutation_p.P25R	NM_018115	NP_060585	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	25					protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GATGTAGGCCGGCGGGTCTCG	0.597													32	42	---	---	---	---	PASS
SYNPO2	171024	broad.mit.edu	37	4	119952527	119952527	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:119952527C>A	uc003icm.3	+	4	2793	c.2597C>A	c.(2596-2598)CCA>CAA	p.P866Q	SYNPO2_uc010ina.2_Missense_Mutation_p.P866Q|SYNPO2_uc010inb.2_Missense_Mutation_p.P866Q|SYNPO2_uc011cgh.1_Intron|SYNPO2_uc010inc.2_Missense_Mutation_p.P794Q	NM_001128933	NP_001122405	Q9UMS6	SYNP2_HUMAN	synaptopodin 2 isoform b	866						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			ovary(2)	2						AATGAGCTTCCAGGAATGAGT	0.527													9	61	---	---	---	---	PASS
KIAA1109	84162	broad.mit.edu	37	4	123260427	123260427	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:123260427C>A	uc003ieh.2	+	70	12261	c.12216C>A	c.(12214-12216)TCC>TCA	p.S4072S	KIAA1109_uc003iem.2_Silent_p.S428S|KIAA1109_uc003ien.2_Silent_p.S6S	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4072					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGCTGCCATCCCTGGATTTGG	0.423													5	50	---	---	---	---	PASS
LRBA	987	broad.mit.edu	37	4	151749635	151749635	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:151749635G>T	uc010ipj.2	-	30	5342	c.4868C>A	c.(4867-4869)CCT>CAT	p.P1623H	LRBA_uc003ilt.3_Missense_Mutation_p.P282H|LRBA_uc003ilu.3_Missense_Mutation_p.P1623H	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1623						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TGCTGTGTGAGGAGTTACTTC	0.483													6	142	---	---	---	---	PASS
NPY1R	4886	broad.mit.edu	37	4	164247530	164247530	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:164247530C>A	uc003iqm.1	-	2	443	c.177G>T	c.(175-177)CTG>CTT	p.L59L	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	59	Helical; Name=1; (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TGATCAAGGCCAGGTTTCCAG	0.408													45	34	---	---	---	---	PASS
ADAM29	11086	broad.mit.edu	37	4	175897894	175897894	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:175897894A>T	uc003iuc.2	+	5	1888	c.1218A>T	c.(1216-1218)GAA>GAT	p.E406D	ADAM29_uc003iud.2_Missense_Mutation_p.E406D|ADAM29_uc010irr.2_Missense_Mutation_p.E406D|ADAM29_uc011cki.1_Missense_Mutation_p.E406D	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	406	Disintegrin.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GTGTTGTTGAAGAAGGAGAAG	0.413													10	75	---	---	---	---	PASS
VEGFC	7424	broad.mit.edu	37	4	177608422	177608422	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:177608422G>T	uc003ius.1	-	6	1494	c.1064C>A	c.(1063-1065)CCT>CAT	p.P355H		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	355	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.|4.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		ACATTTTCCAGGATTTAGGGG	0.438													5	106	---	---	---	---	PASS
C4orf41	60684	broad.mit.edu	37	4	184585192	184585192	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr4:184585192G>T	uc003ivx.2	+	2	348	c.172G>T	c.(172-174)GGT>TGT	p.G58C	C4orf41_uc003ivw.2_Missense_Mutation_p.G58C|C4orf41_uc010isc.2_Intron	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	58											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		GGTGCTCCCAGGTGACCATGA	0.463													5	41	---	---	---	---	PASS
DNAH5	1767	broad.mit.edu	37	5	13721111	13721111	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:13721111T>C	uc003jfd.2	-	71	12319	c.12277A>G	c.(12277-12279)AAC>GAC	p.N4093D	DNAH5_uc003jfc.2_Missense_Mutation_p.N261D	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4093	AAA 6 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AGCCTTACGTTCGCCATGGTC	0.418									Kartagener_syndrome				8	53	---	---	---	---	PASS
DNAH5	1767	broad.mit.edu	37	5	13913947	13913947	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:13913947C>T	uc003jfd.2	-	11	1483	c.1441G>A	c.(1441-1443)GCC>ACC	p.A481T	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	481	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATTATCTTGGCAAGGCGTCGG	0.368									Kartagener_syndrome				8	56	---	---	---	---	PASS
CDH18	1016	broad.mit.edu	37	5	19747097	19747097	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:19747097G>C	uc003jgc.2	-	3	854	c.477C>G	c.(475-477)TTC>TTG	p.F159L	CDH18_uc003jgd.2_Missense_Mutation_p.F159L|CDH18_uc011cnm.1_Missense_Mutation_p.F159L	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	159	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GTCCATCTGTGAATTTTGGAG	0.348													9	84	---	---	---	---	PASS
CDH10	1008	broad.mit.edu	37	5	24488018	24488018	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:24488018G>T	uc003jgr.1	-	12	2453	c.2121C>A	c.(2119-2121)AAC>AAA	p.N707K	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	707	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GGACGTCCGTGTTATCTGGAG	0.483										HNSCC(23;0.051)			11	49	---	---	---	---	PASS
CDH10	1008	broad.mit.edu	37	5	24488077	24488077	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:24488077G>T	uc003jgr.1	-	12	2394	c.2062C>A	c.(2062-2064)CGA>AGA	p.R688R	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	688	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ATAATATCTCGCCGGAGCTTT	0.483										HNSCC(23;0.051)			25	17	---	---	---	---	PASS
CDH10	1008	broad.mit.edu	37	5	24509858	24509858	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:24509858C>T	uc003jgr.1	-	7	1405	c.1073G>A	c.(1072-1074)CGT>CAT	p.R358H	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	358	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GTAATAAAAACGGGGATCTAC	0.363										HNSCC(23;0.051)			25	24	---	---	---	---	PASS
PDZD2	23037	broad.mit.edu	37	5	32074686	32074686	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:32074686A>C	uc003jhl.2	+	18	3862	c.3474A>C	c.(3472-3474)AGA>AGC	p.R1158S	PDZD2_uc003jhm.2_Missense_Mutation_p.R1158S|PDZD2_uc011cnx.1_Missense_Mutation_p.R984S	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1158					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						TGGACTCGAGAGTCCAGGCCA	0.547													18	10	---	---	---	---	PASS
IL7R	3575	broad.mit.edu	37	5	35876119	35876119	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:35876119T>A	uc003jjs.2	+	8	1000	c.911T>A	c.(910-912)CTG>CAG	p.L304Q	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	304	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GAAAGTTTCCTGGACTGCCAG	0.408													6	60	---	---	---	---	PASS
UGT3A2	167127	broad.mit.edu	37	5	36035961	36035961	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:36035961G>T	uc003jjz.1	-	7	1504	c.1411C>A	c.(1411-1413)CTC>ATC	p.L471I	UGT3A2_uc011cos.1_Missense_Mutation_p.L437I|UGT3A2_uc011cot.1_Missense_Mutation_p.L169I	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	471	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TAGGGCTTGAGGTGCGTCGCG	0.617													4	21	---	---	---	---	PASS
LMBRD2	92255	broad.mit.edu	37	5	36122985	36122985	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:36122985G>T	uc003jkb.1	-	8	1316	c.901C>A	c.(901-903)CCA>ACA	p.P301T		NM_001007527	NP_001007528	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	301	Cytoplasmic (Potential).					integral to membrane					0	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTTTCACTTGGATAGATACTA	0.274													4	23	---	---	---	---	PASS
C5orf33	133686	broad.mit.edu	37	5	36226629	36226629	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:36226629T>A	uc003jkf.3	-	3	426	c.426A>T	c.(424-426)AGA>AGT	p.R142S	C5orf33_uc010iux.2_5'Flank|C5orf33_uc003jkg.3_5'UTR|C5orf33_uc011cov.1_5'UTR	NM_001085411	NP_001078880	Q4G0N4	NAKD1_HUMAN	hypothetical protein LOC133686 isoform 1	142							NAD+ kinase activity				0	all_lung(31;5.63e-05)		Epithelial(62;0.0254)|all cancers(62;0.0805)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CATCATATTCTCTCCTCTTTA	0.348													61	44	---	---	---	---	PASS
NIPBL	25836	broad.mit.edu	37	5	37000926	37000926	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:37000926G>A	uc003jkl.3	+	13	4009	c.3510G>A	c.(3508-3510)AGG>AGA	p.R1170R	NIPBL_uc003jkk.3_Silent_p.R1170R	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1170					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TAGTTGCTAGGAAAATGAAGA	0.294													34	22	---	---	---	---	PASS
FYB	2533	broad.mit.edu	37	5	39202039	39202039	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:39202039G>A	uc003jls.2	-	1	1091	c.1024C>T	c.(1024-1026)CCG>TCG	p.P342S	FYB_uc003jlt.2_Missense_Mutation_p.P342S|FYB_uc003jlu.2_Missense_Mutation_p.P342S|FYB_uc011cpl.1_Missense_Mutation_p.P352S	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	342					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TTCTGTTTCGGGGTGGCTGAA	0.532													7	73	---	---	---	---	PASS
HTR1A	3350	broad.mit.edu	37	5	63257447	63257447	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:63257447T>A	uc011cqt.1	-	1	100	c.100A>T	c.(100-102)AGC>TGC	p.S34C		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	34	Extracellular (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ACTTGGTAGCTGACGGTCACG	0.617													10	29	---	---	---	---	PASS
BDP1	55814	broad.mit.edu	37	5	70805959	70805959	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:70805959G>A	uc003kbp.1	+	17	3303	c.3040G>A	c.(3040-3042)GCA>ACA	p.A1014T	BDP1_uc003kbn.1_Missense_Mutation_p.A1014T|BDP1_uc003kbo.2_Missense_Mutation_p.A1014T	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1014	4.|9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AGATTTGAACGCAACTGGAAG	0.428													14	72	---	---	---	---	PASS
MEF2C	4208	broad.mit.edu	37	5	88119587	88119587	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:88119587G>C	uc003kjj.2	-	2	692	c.19C>G	c.(19-21)CAG>GAG	p.Q7E	MEF2C_uc003kji.2_Missense_Mutation_p.Q7E|MEF2C_uc003kjk.2_Missense_Mutation_p.Q7E|MEF2C_uc003kjm.2_Missense_Mutation_p.Q7E|MEF2C_uc003kjl.2_Missense_Mutation_p.Q7E	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	7	Lys-rich (basic).|MADS-box.				apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		CTCGTAATCTGAATCTTTTTT	0.343										HNSCC(66;0.2)			105	44	---	---	---	---	PASS
FAM114A2	10827	broad.mit.edu	37	5	153409093	153409093	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:153409093C>A	uc003lvb.2	-	5	1039	c.451G>T	c.(451-453)GCA>TCA	p.A151S	FAM114A2_uc003lvc.2_Missense_Mutation_p.A151S|FAM114A2_uc003lvd.2_Missense_Mutation_p.A151S|FAM114A2_uc003lve.2_5'UTR|FAM114A2_uc011dda.1_Missense_Mutation_p.A81S	NM_018691	NP_061161	Q9NRY5	F1142_HUMAN	hypothetical protein LOC10827	151							purine nucleotide binding				0						ACACCAAATGCCCCAGCCACT	0.448													8	10	---	---	---	---	PASS
ATP10B	23120	broad.mit.edu	37	5	160097667	160097667	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:160097667G>T	uc003lym.1	-	7	1325	c.478C>A	c.(478-480)CAG>AAG	p.Q160K	ATP10B_uc003lyp.2_Missense_Mutation_p.Q160K|ATP10B_uc011deg.1_Missense_Mutation_p.Q204K|ATP10B_uc003lyo.2_Missense_Mutation_p.Q132K	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	160	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACATAGGTCTGCTCTTTTCTT	0.458													24	18	---	---	---	---	PASS
HIST1H3I	8354	broad.mit.edu	37	6	27840015	27840015	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:27840015G>A	uc003njy.2	-	1	85	c.79C>T	c.(79-81)CGC>TGC	p.R27C		NM_003533	NP_003524	P68431	H31_HUMAN	histone cluster 1, H3i	27					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						GCGCTCTTGCGAGCCGCCTTG	0.667													4	13	---	---	---	---	PASS
ZKSCAN3	80317	broad.mit.edu	37	6	28327630	28327630	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:28327630G>T	uc003nle.3	+	2	483	c.267G>T	c.(265-267)CTG>CTT	p.L89L	ZKSCAN3_uc010jrc.2_Silent_p.L89L|ZKSCAN3_uc003nlf.3_Intron	NM_024493	NP_077819	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	89	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						TGGAGCTGCTGGTGCTGGAGC	0.652													5	22	---	---	---	---	PASS
WDR46	9277	broad.mit.edu	37	6	33255475	33255475	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:33255475C>T	uc003ods.2	-	7	688	c.644G>A	c.(643-645)CGC>CAC	p.R215H	WDR46_uc011dra.1_Missense_Mutation_p.R161H|WDR46_uc010juo.1_RNA|PFDN6_uc003odt.1_5'Flank|PFDN6_uc010jup.1_5'Flank	NM_005452	NP_005443	O15213	WDR46_HUMAN	WD repeat domain 46 isoform 1	215	WD 1.										0						ATGACCTCGGCGCCCTCCAAA	0.602													10	9	---	---	---	---	PASS
RGL2	5863	broad.mit.edu	37	6	33262480	33262480	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:33262480G>A	uc003odv.2	-	11	1471	c.1338C>T	c.(1336-1338)TCC>TCT	p.S446S	RGL2_uc003odu.2_Silent_p.S6S|RGL2_uc010jur.2_Silent_p.S6S|RGL2_uc003odw.2_Silent_p.S364S|RGL2_uc011drb.1_Silent_p.S364S	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	446	Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						ACTCATCCTTGGAGGCTGCAT	0.582													5	12	---	---	---	---	PASS
TAF11	6882	broad.mit.edu	37	6	34850791	34850791	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:34850791C>T	uc003ojw.1	-	2	323	c.238G>A	c.(238-240)GCA>ACA	p.A80T	UHRF1BP1_uc010jvm.1_RNA|TAF11_uc011dsr.1_Missense_Mutation_p.A80T	NM_005643	NP_005634	Q15544	TAF11_HUMAN	TBP-associated factor 11	80					positive regulation by host of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	transcription factor TFIID complex	protein N-terminus binding|thyroid hormone receptor binding|transcription coactivator activity|vitamin D receptor binding				0						TTTTTGGCTGCAGGATTAAGT	0.348													23	33	---	---	---	---	PASS
TCP11	6954	broad.mit.edu	37	6	35089954	35089954	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:35089954G>T	uc003okd.2	-	5	738	c.557C>A	c.(556-558)CCA>CAA	p.P186Q	TCP11_uc003ojz.1_Missense_Mutation_p.P111Q|TCP11_uc003oka.2_Missense_Mutation_p.P111Q|TCP11_uc003okb.2_Missense_Mutation_p.P110Q|TCP11_uc003okc.2_Missense_Mutation_p.P110Q|TCP11_uc011dsu.1_Missense_Mutation_p.P168Q|TCP11_uc011dsv.1_Missense_Mutation_p.P135Q|TCP11_uc011dsw.1_Missense_Mutation_p.P140Q	NM_001093728	NP_001087197	Q8WWU5	TCP11_HUMAN	t-complex 11 isoform 1	173					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(3)|skin(2)	5						ATCTCGAACTGGTGCACACAG	0.478													5	81	---	---	---	---	PASS
TJAP1	93643	broad.mit.edu	37	6	43471417	43471417	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:43471417C>T	uc003ovd.2	+	10	928	c.552C>T	c.(550-552)TCC>TCT	p.S184S	TJAP1_uc003ovf.2_Silent_p.S174S|TJAP1_uc003ove.2_Silent_p.S174S|TJAP1_uc003ovc.2_Silent_p.S174S|TJAP1_uc010jyp.2_Silent_p.S143S|TJAP1_uc011dvh.1_Silent_p.S174S|TJAP1_uc003ovg.2_Silent_p.S50S|TJAP1_uc011dvi.1_Silent_p.S184S|TJAP1_uc011dvj.1_5'UTR|TJAP1_uc003ovi.2_Silent_p.S50S	NM_001146016	NP_001139488	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 isoform a	184						Golgi apparatus|tight junction	protein binding				0	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GCAACAAGTCCCACTTCCGAA	0.562													11	87	---	---	---	---	PASS
GPR111	222611	broad.mit.edu	37	6	47650109	47650109	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:47650109T>A	uc010jzj.1	+	6	1815	c.1814T>A	c.(1813-1815)CTG>CAG	p.L605Q	GPR111_uc010jzk.1_Missense_Mutation_p.L537Q|GPR111_uc003oyy.2_RNA	NM_153839	NP_722581	Q8IZF7	GP111_HUMAN	G-protein coupled receptor 111	605	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						AAAGCCCTCCTGGCCTTCGTG	0.537													27	29	---	---	---	---	PASS
PKHD1	5314	broad.mit.edu	37	6	51640631	51640631	+	Silent	SNP	T	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:51640631T>G	uc003pah.1	-	54	8805	c.8529A>C	c.(8527-8529)GGA>GGC	p.G2843G	PKHD1_uc010jzn.1_Silent_p.G826G|PKHD1_uc003pai.2_Silent_p.G2843G	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	2843	G8 2.|Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CAATATGAATTCCATTCATAC	0.333													6	46	---	---	---	---	PASS
DOPEY1	23033	broad.mit.edu	37	6	83818789	83818789	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:83818789T>C	uc003pjs.1	+	5	741	c.481T>C	c.(481-483)TAC>CAC	p.Y161H	DOPEY1_uc011dyy.1_Missense_Mutation_p.Y161H|DOPEY1_uc010kbl.1_Missense_Mutation_p.Y161H	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	161					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AGGATCAGAGTACTATGAGAG	0.358													9	48	---	---	---	---	PASS
CNR1	1268	broad.mit.edu	37	6	88854625	88854625	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:88854625G>T	uc011dzq.1	-	2	3932	c.369C>A	c.(367-369)TCC>TCA	p.S123S	CNR1_uc010kbz.2_Silent_p.S123S|CNR1_uc011dzr.1_Silent_p.S123S|CNR1_uc011dzs.1_Silent_p.S123S|CNR1_uc003pmq.3_Silent_p.S123S|CNR1_uc011dzt.1_Silent_p.S123S|CNR1_uc010kca.2_Silent_p.S90S	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	123	Helical; Name=1; (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	CCAGCGTGAGGGACAGGACTG	0.587													6	13	---	---	---	---	PASS
EPHA7	2045	broad.mit.edu	37	6	94120471	94120471	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:94120471C>G	uc003poe.2	-	3	821	c.580G>C	c.(580-582)GCT>CCT	p.A194P	EPHA7_uc003pof.2_Missense_Mutation_p.A194P|EPHA7_uc011eac.1_Missense_Mutation_p.A194P|EPHA7_uc003pog.3_Missense_Mutation_p.A194P	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	194	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GAAACCAAAGCTATGCAAGCC	0.408													12	27	---	---	---	---	PASS
KIAA0776	23376	broad.mit.edu	37	6	96984166	96984166	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:96984166G>T	uc003por.2	+	8	750	c.702G>T	c.(700-702)GTG>GTT	p.V234V	KIAA0776_uc010kck.2_RNA	NM_015323	NP_056138	O94874	UFL1_HUMAN	hypothetical protein LOC23376	234	Involved in CDK5RAP3-binding.				negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity			ovary(1)	1		all_cancers(76;5.83e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0604)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0934)		GAGGCACTGTGGTTGGTGGGA	0.433													5	51	---	---	---	---	PASS
OSTM1	28962	broad.mit.edu	37	6	108375753	108375753	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:108375753T>A	uc003psd.2	-	3	642	c.556A>T	c.(556-558)ACA>TCA	p.T186S		NM_014028	NP_054747	Q86WC4	OSTM1_HUMAN	osteopetrosis associated transmembrane protein 1	186	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0131)|Epithelial(106;0.0438)|OV - Ovarian serous cystadenocarcinoma(136;0.0571)|all cancers(137;0.0581)		AAATATACTGTGCTGTTTGAT	0.264													6	12	---	---	---	---	PASS
ROS1	6098	broad.mit.edu	37	6	117632279	117632279	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:117632279A>T	uc003pxp.1	-	39	6336	c.6137T>A	c.(6136-6138)TTT>TAT	p.F2046Y	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2046	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AGGACCATAAAACTGTAAGAA	0.279			T	GOPC|ROS1	glioblastoma|NSCLC								16	18	---	---	---	---	PASS
TAAR8	83551	broad.mit.edu	37	6	132874419	132874419	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:132874419C>T	uc011ecj.1	+	1	588	c.588C>T	c.(586-588)GGC>GGT	p.G196G		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	196	Helical; Name=5; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		TAAGTCAAGGCTGGGTGTTGA	0.378													14	42	---	---	---	---	PASS
AHI1	54806	broad.mit.edu	37	6	135784438	135784438	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:135784438C>T	uc003qgi.2	-	8	1140	c.756G>A	c.(754-756)TTG>TTA	p.L252L	AHI1_uc003qgh.2_Silent_p.L252L|AHI1_uc003qgj.2_Silent_p.L252L|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Silent_p.L252L	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	252						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		CAGAGATGGTCAATGTACTAC	0.323													23	36	---	---	---	---	PASS
STXBP5	134957	broad.mit.edu	37	6	147685233	147685233	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:147685233A>G	uc003qlz.2	+	25	3173	c.3012A>G	c.(3010-3012)GCA>GCG	p.A1004A	STXBP5_uc010khz.1_Silent_p.A968A|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Silent_p.A659A	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	1004	WD 14.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		ATGGACAAGCATTATACCTTG	0.363													16	31	---	---	---	---	PASS
SYNE1	23345	broad.mit.edu	37	6	152605154	152605154	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr6:152605154T>C	uc010kiw.2	-	96	18768	c.18166A>G	c.(18166-18168)ACC>GCC	p.T6056A	SYNE1_uc010kiv.2_Missense_Mutation_p.T580A|SYNE1_uc003qos.3_Missense_Mutation_p.T580A|SYNE1_uc003qot.3_Missense_Mutation_p.T5985A|SYNE1_uc003qou.3_Missense_Mutation_p.T6056A|SYNE1_uc010kiy.1_Missense_Mutation_p.T235A	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6056	Spectrin 20.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATCCTGATGGTGGACATTCGC	0.532										HNSCC(10;0.0054)			7	25	---	---	---	---	PASS
MAD1L1	8379	broad.mit.edu	37	7	2259027	2259027	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:2259027C>T	uc003slh.1	-	6	802	c.536G>A	c.(535-537)CGG>CAG	p.R179Q	MAD1L1_uc003slf.1_Missense_Mutation_p.R179Q|MAD1L1_uc003slg.1_Missense_Mutation_p.R179Q|MAD1L1_uc010ksh.1_Missense_Mutation_p.R179Q|MAD1L1_uc003sli.1_Missense_Mutation_p.R87Q|MAD1L1_uc010ksi.1_Missense_Mutation_p.R132Q|MAD1L1_uc010ksj.2_Missense_Mutation_p.R179Q	NM_001013836	NP_001013858	Q9Y6D9	MD1L1_HUMAN	MAD1-like 1 protein	179	Potential.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		GCGCTTCACCCGCATCTCCTG	0.632													4	12	---	---	---	---	PASS
SNX13	23161	broad.mit.edu	37	7	17915137	17915137	+	Silent	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:17915137A>T	uc003stw.1	-	7	843	c.630T>A	c.(628-630)CGT>CGA	p.R210R	SNX13_uc003stv.2_Silent_p.R210R|SNX13_uc010kuc.2_Silent_p.R7R|SNX13_uc003stx.1_Silent_p.R130R			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	210	PXA.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					ACACTAGATCACGGCAAACCT	0.358													17	32	---	---	---	---	PASS
SNX13	23161	broad.mit.edu	37	7	17930108	17930108	+	Splice_Site	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:17930108C>A	uc003stw.1	-	5	532	c.319_splice	c.e5-1	p.V107_splice	SNX13_uc003stv.2_Splice_Site_p.V107_splice|SNX13_uc010kuc.2_Splice_Site|SNX13_uc003stx.1_Splice_Site_p.V27_splice|SNX13_uc003sty.2_Splice_Site_p.V107_splice			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;						cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					ACTGGATAACCTATAACAAAA	0.289													5	50	---	---	---	---	PASS
INMT	11185	broad.mit.edu	37	7	30793552	30793552	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:30793552C>G	uc003tbs.1	+	2	376	c.360C>G	c.(358-360)AAC>AAG	p.N120K	FAM188B_uc010kwe.2_5'UTR|INMT_uc010kwc.1_RNA|INMT_uc010kwd.1_Missense_Mutation_p.N119K	NM_006774	NP_006765	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	120						cytoplasm	amine N-methyltransferase activity				0						TGGAAGGAAACAGGTAGGGGT	0.572													9	52	---	---	---	---	PASS
ADCYAP1R1	117	broad.mit.edu	37	7	31142865	31142865	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:31142865C>A	uc003tca.1	+	14	1284	c.1061C>A	c.(1060-1062)TCC>TAC	p.S354Y	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.S333Y|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.S382Y|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.S382Y|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.S381Y|ADCYAP1R1_uc003tcf.1_Missense_Mutation_p.S112Y	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	354	Helical; Name=6; (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						CTGGCCCGGTCCACCCTGCTG	0.582													32	59	---	---	---	---	PASS
ZNF479	90827	broad.mit.edu	37	7	57187734	57187734	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:57187734C>A	uc010kzo.2	-	5	1659	c.1388G>T	c.(1387-1389)AGA>ATA	p.R463I		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TGTGTAGGGTCTCTCTCCAGT	0.418													34	55	---	---	---	---	PASS
ZNF117	51351	broad.mit.edu	37	7	64439401	64439401	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:64439401T>A	uc003ttr.2	-	4	1833	c.548A>T	c.(547-549)CAT>CTT	p.H183L		NM_015852	NP_056936	Q03924	ZN117_HUMAN	zinc finger protein 117	183	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Lung NSC(55;0.0295)|all_lung(88;0.0691)				AATTCTCTTATGTCTAATAAG	0.348													5	54	---	---	---	---	PASS
ZNF92	168374	broad.mit.edu	37	7	64863284	64863284	+	Nonsense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:64863284G>A	uc003ttz.2	+	4	400	c.257G>A	c.(256-258)TGG>TAG	p.W86*	ZNF92_uc003tua.2_Nonsense_Mutation_p.W17*|ZNF92_uc010kzu.2_Nonsense_Mutation_p.W54*|ZNF92_uc003tub.2_Nonsense_Mutation_p.W10*	NM_152626	NP_689839	Q03936	ZNF92_HUMAN	zinc finger protein 92 isoform 2	86						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(55;0.159)				CAAGATGTTTGGCCAGAGCAC	0.308													7	53	---	---	---	---	PASS
POM121	9883	broad.mit.edu	37	7	72400567	72400567	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:72400567C>G	uc003twk.2	+	5	1193	c.1193C>G	c.(1192-1194)ACA>AGA	p.T398R	POM121_uc003twj.2_Missense_Mutation_p.T133R|POM121_uc010lam.1_Missense_Mutation_p.T133R	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	398	Ser-rich.|Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				AGCTCCTTGACAGGCGCTTAC	0.507													26	161	---	---	---	---	PASS
GTF2IRD1	9569	broad.mit.edu	37	7	73969722	73969722	+	Splice_Site	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:73969722G>C	uc003uaq.2	+	19	2360	c.1967_splice	c.e19-1	p.G656_splice	GTF2IRD1_uc010lbq.2_Intron|GTF2IRD1_uc003uap.2_Intron|GTF2IRD1_uc003uar.1_Intron	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1							nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						TTGGGTCCCAGGAACTGCCTC	0.632													4	21	---	---	---	---	PASS
STYXL1	51657	broad.mit.edu	37	7	75630284	75630284	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:75630284A>T	uc003uej.3	-	8	907	c.734T>A	c.(733-735)TTT>TAT	p.F245Y	STYXL1_uc003uef.2_Intron|STYXL1_uc011kgf.1_Intron|STYXL1_uc011kgg.1_Intron|STYXL1_uc003ueh.2_Missense_Mutation_p.F107Y|STYXL1_uc003uek.3_Missense_Mutation_p.F149Y|STYXL1_uc003uel.2_Missense_Mutation_p.F245Y|STYXL1_uc003uem.2_Missense_Mutation_p.F245Y|STYXL1_uc010ldg.1_Intron|STYXL1_uc010ldh.1_Missense_Mutation_p.F245Y|STYXL1_uc003uen.1_Intron	NM_016086	NP_057170	Q9Y6J8	STYL1_HUMAN	map kinase phosphatase-like protein MK-STYX	245	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity				0						TTGGGTGGAAAAGATCAGAAT	0.562													5	73	---	---	---	---	PASS
CACNA2D1	781	broad.mit.edu	37	7	81591298	81591298	+	Nonsense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:81591298G>A	uc003uhr.1	-	36	3134	c.2878C>T	c.(2878-2880)CAG>TAG	p.Q960*	CACNA2D1_uc011kgy.1_Nonsense_Mutation_p.Q172*	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	972	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ATGCAGCTCTGCTTGGACAGG	0.448													9	54	---	---	---	---	PASS
SEMA3E	9723	broad.mit.edu	37	7	83037796	83037796	+	Silent	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:83037796T>C	uc003uhy.1	-	6	1024	c.558A>G	c.(556-558)GAA>GAG	p.E186E		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	186	Sema.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				CAGCAAACAATTCACTACCTA	0.423													14	24	---	---	---	---	PASS
DMTF1	9988	broad.mit.edu	37	7	86823124	86823124	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:86823124G>T	uc003uih.2	+	16	2060	c.1734G>T	c.(1732-1734)GAG>GAT	p.E578D	DMTF1_uc003uii.2_Missense_Mutation_p.E312D|DMTF1_uc003uij.2_Missense_Mutation_p.E312D|DMTF1_uc011khb.1_Missense_Mutation_p.E490D|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Missense_Mutation_p.E578D|DMTF1_uc003uin.2_Missense_Mutation_p.E312D	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	578	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Required for transcriptional activation (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					TTGCCACAGAGGACATCACTT	0.423													7	103	---	---	---	---	PASS
STEAP2	261729	broad.mit.edu	37	7	89854850	89854850	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:89854850T>A	uc003ujz.2	+	2	847	c.454T>A	c.(454-456)TGG>AGG	p.W152R	STEAP2_uc003ujy.2_Missense_Mutation_p.W194R|STEAP2_uc010len.2_Missense_Mutation_p.W152R|STEAP2_uc003uka.2_Missense_Mutation_p.W152R|STEAP2_uc003ukb.2_Missense_Mutation_p.W152R|STEAP2_uc003ukc.2_Missense_Mutation_p.W152R|STEAP2_uc003ukd.2_Missense_Mutation_p.W152R	NM_152999	NP_694544	Q8NFT2	STEA2_HUMAN	six transmembrane epithelial antigen of the	152					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity			ovary(2)	2	all_hematologic(106;0.112)					TGTCTCAGCTTGGGCACTTCA	0.363													21	86	---	---	---	---	PASS
COL1A2	1278	broad.mit.edu	37	7	94038087	94038087	+	Silent	SNP	C	T	T	rs1800227		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:94038087C>T	uc003ung.1	+	16	1215	c.744C>T	c.(742-744)CCC>CCT	p.P248P	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	248					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TTCAGGGTCCCATTGGGTCTG	0.443										HNSCC(75;0.22)			10	20	---	---	---	---	PASS
DYNC1I1	1780	broad.mit.edu	37	7	95606829	95606829	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:95606829G>T	uc003uoc.3	+	7	824	c.547G>T	c.(547-549)GAG>TAG	p.E183*	DYNC1I1_uc003uod.3_Nonsense_Mutation_p.E166*|DYNC1I1_uc003uob.2_Nonsense_Mutation_p.E146*|DYNC1I1_uc003uoe.3_Nonsense_Mutation_p.E163*|DYNC1I1_uc010lfl.2_Nonsense_Mutation_p.E172*	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	183					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TCTAGAGGATGAGGAAGATGA	0.378													4	27	---	---	---	---	PASS
PIK3CG	5294	broad.mit.edu	37	7	106545676	106545676	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:106545676C>T	uc003vdv.3	+	11	3238	c.3153C>T	c.(3151-3153)ATC>ATT	p.I1051I	PIK3CG_uc003vdu.2_Silent_p.I1051I|PIK3CG_uc003vdw.2_Silent_p.I1051I	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	1051	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding	p.I1051I(1)		lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						TTGAATATATCCGGGATGCCC	0.433													10	113	---	---	---	---	PASS
CTTNBP2	83992	broad.mit.edu	37	7	117432706	117432706	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:117432706A>G	uc003vjf.2	-	4	636	c.544T>C	c.(544-546)TCA>CCA	p.S182P		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	182	Potential.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		ACTTTGCCTGAGAGCTGCTTG	0.517													6	77	---	---	---	---	PASS
ING3	54556	broad.mit.edu	37	7	120593375	120593375	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:120593375G>C	uc003vjn.2	+	3	252	c.118G>C	c.(118-120)GAA>CAA	p.E40Q	ING3_uc011knr.1_Missense_Mutation_p.E40Q|ING3_uc003vjl.2_Missense_Mutation_p.E40Q|ING3_uc003vjm.1_Missense_Mutation_p.E40Q|ING3_uc003vjo.2_5'UTR|ING3_uc003vjp.2_Missense_Mutation_p.E40Q|ING3_uc011kns.1_Missense_Mutation_p.E25Q	NM_019071	NP_061944	Q9NXR8	ING3_HUMAN	inhibitor of growth family, member 3 isoform 1	40					histone H2A acetylation|histone H4 acetylation|positive regulation of apoptosis|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|Piccolo NuA4 histone acetyltransferase complex	zinc ion binding			ovary(1)	1	all_neural(327;0.117)					GGATCAACTAGAACAAAGAGT	0.308													9	59	---	---	---	---	PASS
TAS2R16	50833	broad.mit.edu	37	7	122635112	122635112	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:122635112G>A	uc003vkl.1	-	1	643	c.577C>T	c.(577-579)CTG>TTG	p.L193L		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	193	Helical; Name=5; (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						GTGGAGGCCAGGAACAGGATG	0.448													24	90	---	---	---	---	PASS
CNOT4	4850	broad.mit.edu	37	7	135073610	135073610	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:135073610G>T	uc003vsv.1	-	11	1971	c.1664C>A	c.(1663-1665)TCA>TAA	p.S555*	CNOT4_uc003vss.2_Intron|CNOT4_uc011kpz.1_Intron|CNOT4_uc003vst.2_Intron|CNOT4_uc003vsu.1_Nonsense_Mutation_p.S552*|CNOT4_uc011kpy.1_Intron	NM_001008225	NP_001008226	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	555					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding				0						GGAAGAGGTTGACAGTGGCAT	0.463													12	56	---	---	---	---	PASS
CHRM2	1129	broad.mit.edu	37	7	136700851	136700851	+	Silent	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:136700851T>C	uc003vtf.1	+	4	1862	c.1239T>C	c.(1237-1239)TGT>TGC	p.C413C	CHRM2_uc003vtg.1_Silent_p.C413C|CHRM2_uc003vtj.1_Silent_p.C413C|CHRM2_uc003vtk.1_Silent_p.C413C|CHRM2_uc003vtl.1_Silent_p.C413C|CHRM2_uc003vtm.1_Silent_p.C413C|CHRM2_uc003vti.1_Silent_p.C413C|CHRM2_uc003vto.1_Silent_p.C413C|CHRM2_uc003vtn.1_Silent_p.C413C|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	413	Extracellular (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ACACCTTTTGTGCACCTTGCA	0.473													17	64	---	---	---	---	PASS
TRPV5	56302	broad.mit.edu	37	7	142627186	142627186	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:142627186C>T	uc003wby.1	-	3	580	c.316G>A	c.(316-318)GTC>ATC	p.V106I	TRPV5_uc003wbz.2_Missense_Mutation_p.V106I	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	106	Cytoplasmic (Potential).|ANK 2.				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					GGCTCAAAGACCAGCTCTGGG	0.557													7	53	---	---	---	---	PASS
ABCF2	10061	broad.mit.edu	37	7	150921189	150921189	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:150921189G>A	uc003wjp.2	-	4	490	c.379C>T	c.(379-381)CTG>TTG	p.L127L	ABCF2_uc003wjo.1_Silent_p.L127L	NM_007189	NP_009120	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F, member 2	127	ABC transporter 1.					ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCAGAGAGCAGCATGGACTTT	0.547													29	27	---	---	---	---	PASS
ABCF2	10061	broad.mit.edu	37	7	150921902	150921902	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr7:150921902G>A	uc003wjp.2	-	3	438	c.327C>T	c.(325-327)AAC>AAT	p.N109N	ABCF2_uc003wjo.1_Silent_p.N109N	NM_007189	NP_009120	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F, member 2	109	ABC transporter 1.					ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GACGGCCTGAGTTTAATTCCA	0.488													36	45	---	---	---	---	PASS
SH2D4A	63898	broad.mit.edu	37	8	19214747	19214747	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:19214747A>G	uc003wzb.2	+	5	883	c.547A>G	c.(547-549)ATG>GTG	p.M183V	SH2D4A_uc011kym.1_Missense_Mutation_p.M138V|SH2D4A_uc003wzc.2_Missense_Mutation_p.M183V	NM_022071	NP_071354	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	183						cytoplasm|nucleus	protein binding				0				Colorectal(111;0.0732)		TATTCAACAAATGTTGGCAGA	0.403													32	18	---	---	---	---	PASS
PPP3CC	5533	broad.mit.edu	37	8	22368619	22368619	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:22368619C>T	uc003xbs.2	+	5	832	c.505C>T	c.(505-507)CAG>TAG	p.Q169*	PPP3CC_uc003xbr.1_Nonsense_Mutation_p.Q169*|PPP3CC_uc011kzi.1_Nonsense_Mutation_p.Q169*|PPP3CC_uc003xbt.2_Nonsense_Mutation_p.Q169*	NM_005605	NP_005596	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma	169					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		ATATTCGGAACAGGTGTATGA	0.398													10	87	---	---	---	---	PASS
NRG1	3084	broad.mit.edu	37	8	32599566	32599566	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:32599566G>T	uc003xiv.2	+	7	1190	c.673G>T	c.(673-675)GTG>TTG	p.V225L	NRG1_uc003xip.2_Intron|NRG1_uc010lvn.2_Intron|NRG1_uc003xis.2_Intron|NRG1_uc011lbf.1_Intron|NRG1_uc010lvo.2_Intron|NRG1_uc003xiu.2_Intron|NRG1_uc003xiw.2_Intron|NRG1_uc003xit.2_Missense_Mutation_p.V225L|NRG1_uc010lvr.2_Intron|NRG1_uc010lvs.2_Intron|NRG1_uc010lvp.2_Intron|NRG1_uc010lvq.2_Intron|NRG1_uc003xix.2_Missense_Mutation_p.V115L|NRG1_uc003xiy.2_Intron|NRG1_uc010lvt.2_Intron|NRG1_uc011lbg.1_Missense_Mutation_p.V71L|NRG1_uc011lbh.1_Intron|NRG1_uc003xiz.1_RNA|NRG1_uc003xja.2_Missense_Mutation_p.V28L	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	225	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TACTGAGAATGTGCCCATGAA	0.403													33	12	---	---	---	---	PASS
POLB	5423	broad.mit.edu	37	8	42196567	42196567	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:42196567C>T	uc003xoz.1	+	2	212	c.99C>T	c.(97-99)ATC>ATT	p.I33I	POLB_uc003xpa.1_Silent_p.I33I|POLB_uc011lcs.1_Intron	NM_002690	NP_002681	P06746	DPOLB_HUMAN	DNA-directed DNA polymerase beta	33					DNA-dependent DNA replication	cytoplasm|nucleoplasm|spindle microtubule	DNA-(apurinic or apyrimidinic site) lyase activity|DNA-directed DNA polymerase activity|enzyme binding|metal ion binding|microtubule binding			ovary(1)|breast(1)	2	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.18e-11)|Lung(22;0.00467)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|LUSC - Lung squamous cell carcinoma(45;0.024)		Cytarabine(DB00987)	GCCAAGCTATCCACAAGTACA	0.483								DNA_polymerases_(catalytic_subunits)					6	33	---	---	---	---	PASS
RNF170	81790	broad.mit.edu	37	8	42729125	42729125	+	Silent	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:42729125T>C	uc003xpo.2	-	3	639	c.162A>G	c.(160-162)CCA>CCG	p.P54P	RNF170_uc011lcx.1_Silent_p.P54P|RNF170_uc010lxp.2_5'UTR|RNF170_uc003xpm.2_Silent_p.P54P|RNF170_uc003xpp.2_5'UTR|RNF170_uc003xpn.2_5'UTR|RNF170_uc003xpq.3_Silent_p.P54P	NM_001160223	NP_001153695	Q96K19	RN170_HUMAN	ring finger protein 170 isoform a	54						integral to membrane	zinc ion binding				0	all_lung(13;1.25e-11)|Lung NSC(13;3.55e-10)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00645)|Lung NSC(58;0.0176)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			CCTGGTTTTCTGGGTGAATGT	0.328													7	39	---	---	---	---	PASS
HGSNAT	138050	broad.mit.edu	37	8	43033220	43033220	+	Silent	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:43033220T>C	uc003xpx.3	+	10	903	c.855T>C	c.(853-855)TTT>TTC	p.F285F		NM_152419	NP_689632	Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase	313	Helical; (Potential).				lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity				0	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			TTTTTAGGTTTGTATTTATTA	0.328													53	51	---	---	---	---	PASS
PXDNL	137902	broad.mit.edu	37	8	52320691	52320691	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:52320691C>A	uc003xqu.3	-	17	3594	c.3493G>T	c.(3493-3495)GTT>TTT	p.V1165F	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1165					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AAGTTCTTAACTGAAGTCAAA	0.398													8	45	---	---	---	---	PASS
OPRK1	4986	broad.mit.edu	37	8	54142385	54142385	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:54142385G>A	uc003xrh.1	-	3	990	c.615C>T	c.(613-615)GTC>GTT	p.V205V	OPRK1_uc003xri.1_Silent_p.V205V|OPRK1_uc010lyc.1_Silent_p.V116V	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	205	Extracellular (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CAATGACATCGACGTCTGGAG	0.423													5	42	---	---	---	---	PASS
NKAIN3	286183	broad.mit.edu	37	8	63659590	63659590	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:63659590G>T	uc010lyq.1	+	4	505	c.373G>T	c.(373-375)GGC>TGC	p.G125C		NM_173688	NP_775959	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3	125						integral to membrane|plasma membrane					0	Breast(64;0.127)	Lung NSC(129;0.187)				CTCAGCCCATGGCATGATGGA	0.507													7	37	---	---	---	---	PASS
TRPA1	8989	broad.mit.edu	37	8	72948636	72948636	+	Silent	SNP	C	G	G	rs146434598	byFrequency	TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:72948636C>G	uc003xza.2	-	21	2617	c.2442G>C	c.(2440-2442)ACG>ACC	p.T814T	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	814	Helical; Name=3; (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	AAATGATGCCCGTCGTGTAGA	0.353													5	44	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77775400	77775400	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:77775400C>A	uc003yav.2	+	11	9702	c.9315C>A	c.(9313-9315)CTC>CTA	p.L3105L		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3101	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCCTGTCTCTCAGCAGTGCCC	0.423										HNSCC(33;0.089)			6	6	---	---	---	---	PASS
FAM92A1	137392	broad.mit.edu	37	8	94717142	94717142	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:94717142C>T	uc010maq.2	+	4	439	c.336C>T	c.(334-336)GAC>GAT	p.D112D	FAM92A1_uc003yfu.1_RNA|FAM92A1_uc003yfv.3_RNA	NM_145269	NP_660312	A1XBS5	F92A1_HUMAN	hypothetical protein LOC137392	112	Potential.										0	Breast(36;2.4e-06)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			TGCAGGATGACCTCAAAGCAA	0.308													22	49	---	---	---	---	PASS
VPS13B	157680	broad.mit.edu	37	8	100050736	100050736	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:100050736C>A	uc003yiv.2	+	3	344	c.233C>A	c.(232-234)CCA>CAA	p.P78Q	VPS13B_uc003yiw.2_Missense_Mutation_p.P78Q|VPS13B_uc003yit.2_Missense_Mutation_p.P78Q|VPS13B_uc003yiu.1_Missense_Mutation_p.P78Q|VPS13B_uc003yis.2_Missense_Mutation_p.P78Q|VPS13B_uc011lgy.1_5'UTR	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	78					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GGTTCAGAACCAGTGGTAATT	0.318													4	29	---	---	---	---	PASS
PABPC1	26986	broad.mit.edu	37	8	101719181	101719181	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:101719181G>C	uc003yjs.1	-	10	1885	c.1381C>G	c.(1381-1383)CCA>GCA	p.P461A	PABPC1_uc011lhc.1_Missense_Mutation_p.P429A|PABPC1_uc011lhd.1_Missense_Mutation_p.P416A|PABPC1_uc003yjt.1_Missense_Mutation_p.P458A|PABPC1_uc003yju.2_Intron	NM_002568	NP_002559	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	461					mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity				0	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			CTAAATGGTGGTCTAGGAGCA	0.418													12	95	---	---	---	---	PASS
PKHD1L1	93035	broad.mit.edu	37	8	110495260	110495260	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:110495260T>C	uc003yne.2	+	57	9606	c.9502T>C	c.(9502-9504)TAT>CAT	p.Y3168H		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3168	Extracellular (Potential).|G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACATTCAATATATAAAACTAA	0.408										HNSCC(38;0.096)			18	26	---	---	---	---	PASS
RAD21	5885	broad.mit.edu	37	8	117862949	117862949	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:117862949G>T	uc003yod.2	-	12	1816	c.1528C>A	c.(1528-1530)CCA>ACA	p.P510T		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	510	Pro-rich.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					CAGATATTTGGAGGTTCTTCT	0.328													6	71	---	---	---	---	PASS
TAF2	6873	broad.mit.edu	37	8	120831664	120831664	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:120831664C>A	uc003you.2	-	3	491	c.221G>T	c.(220-222)CGA>CTA	p.R74L		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	74					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			GATCCTTACTCGGTATATTCT	0.343													5	100	---	---	---	---	PASS
LRRC6	23639	broad.mit.edu	37	8	133673830	133673830	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:133673830A>G	uc003ytk.2	-	2	128	c.54T>C	c.(52-54)TGT>TGC	p.C18C	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	18						cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			AAAAAATGACACAGTCGTTGT	0.363													13	39	---	---	---	---	PASS
TG	7038	broad.mit.edu	37	8	133900281	133900281	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:133900281G>T	uc003ytw.2	+	10	2270	c.2229G>T	c.(2227-2229)CAG>CAT	p.Q743H		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	743	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGACGGTGCAGGCCCTGCTCT	0.532													9	33	---	---	---	---	PASS
SLC45A4	57210	broad.mit.edu	37	8	142228949	142228949	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:142228949G>A	uc003ywd.1	-	4	945	c.637C>T	c.(637-639)CGC>TGC	p.R213C	SLC45A4_uc003ywc.1_Missense_Mutation_p.R213C|SLC45A4_uc010meq.1_Missense_Mutation_p.R211C	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	264					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TCAGCGCTGCGCTCCTGCTGC	0.662													26	35	---	---	---	---	PASS
PCSK5	5125	broad.mit.edu	37	9	78794566	78794566	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr9:78794566A>C	uc004ajz.2	+	15	2493	c.1955A>C	c.(1954-1956)CAC>CCC	p.H652P	PCSK5_uc004aka.2_RNA|PCSK5_uc004akb.2_5'Flank	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	652	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						GGACCAGACCACTGCAATGAC	0.478													5	25	---	---	---	---	PASS
FLJ46321	389763	broad.mit.edu	37	9	84609023	84609023	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr9:84609023G>T	uc004amn.2	+	4	3685	c.3638G>T	c.(3637-3639)AGG>ATG	p.R1213M		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1213						integral to membrane					0						TTGGTCCAGAGGAAGCATAGC	0.403													6	122	---	---	---	---	PASS
NR4A3	8013	broad.mit.edu	37	9	102626002	102626002	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr9:102626002C>A	uc004baf.1	+	8	2463	c.1734C>A	c.(1732-1734)CCC>CCA	p.P578P	NR4A3_uc004bag.1_Silent_p.P578P|NR4A3_uc004bai.2_Silent_p.P589P	NM_006981	NP_008912	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	578					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				CTCTGGAGCCCACCGAGTCCA	0.517			T	EWSR1	extraskeletal myxoid chondrosarcoma								13	19	---	---	---	---	PASS
OR13C4	138804	broad.mit.edu	37	9	107289280	107289280	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr9:107289280T>A	uc011lvn.1	-	1	211	c.211A>T	c.(211-213)ATC>TTC	p.I71F		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GTATAGCAGATATCCAGGAAA	0.438													11	71	---	---	---	---	PASS
SLC25A25	114789	broad.mit.edu	37	9	130854346	130854346	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr9:130854346G>T	uc004btd.2	+	1	219	c.197G>T	c.(196-198)GGA>GTA	p.G66V	SLC25A25_uc004btb.2_Intron|SLC25A25_uc004btc.2_Missense_Mutation_p.G66V	NM_001006642	NP_001006643	Q6KCM7	SCMC2_HUMAN	solute carrier family 25, member 25 isoform c	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding				0						CTGGTGGTTGGACCTGCAGAG	0.542													35	20	---	---	---	---	PASS
SPTAN1	6709	broad.mit.edu	37	9	131374420	131374420	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr9:131374420G>A	uc004bvl.3	+	38	5036	c.4923G>A	c.(4921-4923)CAG>CAA	p.Q1641Q	SPTAN1_uc004bvm.3_Silent_p.Q1646Q|SPTAN1_uc004bvn.3_Silent_p.Q1621Q	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	1641	Spectrin 17.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ACCAGTGGCAGTTCTTGGTGC	0.493													16	60	---	---	---	---	PASS
GTF3C4	9329	broad.mit.edu	37	9	135554019	135554019	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr9:135554019G>T	uc010mzv.2	+	2	1271	c.1013G>T	c.(1012-1014)GGA>GTA	p.G338V	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	338					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		AGTGCTTTTGGACCCATAAAA	0.413													5	67	---	---	---	---	PASS
RXRA	6256	broad.mit.edu	37	9	137328331	137328331	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr9:137328331C>T	uc004cfb.2	+	10	1422	c.1260C>T	c.(1258-1260)CTC>CTT	p.L420L	RXRA_uc004cfc.1_Silent_p.L323L	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	420	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	AGCTCTTGCTCCGCCTGCCGG	0.612													38	14	---	---	---	---	PASS
CAMSAP1	157922	broad.mit.edu	37	9	138710429	138710429	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr9:138710429C>A	uc004cgr.3	-	13	3993	c.3993G>T	c.(3991-3993)GAG>GAT	p.E1331D	CAMSAP1_uc004cgq.3_Missense_Mutation_p.E1221D|CAMSAP1_uc010nbg.2_Missense_Mutation_p.E1053D	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	1331						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		CCTTCTCCTCCTCCTTCCGCA	0.647													4	23	---	---	---	---	PASS
DIP2C	22982	broad.mit.edu	37	10	373117	373117	+	Splice_Site	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:373117C>A	uc001ifp.2	-	31	3844	c.3754_splice	c.e31-1	p.A1252_splice		NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C							nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GCCCTCGCGCCTGGAGATGAT	0.567													20	8	---	---	---	---	PASS
STAM	8027	broad.mit.edu	37	10	17746497	17746497	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:17746497C>A	uc001ipj.1	+	10	1196	c.980C>A	c.(979-981)CCA>CAA	p.P327Q	STAM_uc009xjw.1_Missense_Mutation_p.Q25K	NM_003473	NP_003464	Q92783	STAM1_HUMAN	signal transducing adaptor molecule 1	327					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2						CCAGACCTACCAGAGCTGCTT	0.373													5	57	---	---	---	---	PASS
KIAA1462	57608	broad.mit.edu	37	10	30316392	30316392	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:30316392C>T	uc001iux.2	-	2	2744	c.2685G>A	c.(2683-2685)AGG>AGA	p.R895R	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.R757R|KIAA1462_uc009xle.1_Silent_p.R895R	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	895										ovary(4)	4						GCACCCACATCCTCGGCTGTG	0.637													10	42	---	---	---	---	PASS
PARD3	56288	broad.mit.edu	37	10	34625161	34625161	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:34625161C>T	uc010qej.1	-	18	2580	c.2580G>A	c.(2578-2580)GAG>GAA	p.E860E	PARD3_uc010qek.1_Silent_p.E857E|PARD3_uc010qel.1_Silent_p.E860E|PARD3_uc010qem.1_Silent_p.E844E|PARD3_uc010qen.1_Silent_p.E814E|PARD3_uc010qeo.1_Silent_p.E814E|PARD3_uc010qep.1_Silent_p.E770E|PARD3_uc010qeq.1_Intron|PARD3_uc001ixo.1_Silent_p.E573E|PARD3_uc001ixp.1_Silent_p.E691E|PARD3_uc001ixq.1_Silent_p.E814E|PARD3_uc001ixr.1_Silent_p.E857E|PARD3_uc001ixt.1_Silent_p.E678E|PARD3_uc001ixu.1_Silent_p.E802E|PARD3_uc001ixs.1_Silent_p.E483E	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	860	Interacts with PRKCZ (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				TGAGTTTAGTCTCGTCAGCTA	0.408													13	11	---	---	---	---	PASS
ZNF33B	7582	broad.mit.edu	37	10	43089100	43089100	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:43089100C>T	uc001jaf.1	-	5	1413	c.1298G>A	c.(1297-1299)AGA>AAA	p.R433K	ZNF33B_uc009xmg.1_Intron|ZNF33B_uc001jae.1_Intron|ZNF33B_uc001jag.1_Missense_Mutation_p.R321K|ZNF33B_uc001jad.2_Intron	NM_006955	NP_008886	Q06732	ZN33B_HUMAN	zinc finger protein 33B	433	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGTGTGTGTTCTCTGATGTTT	0.418													15	54	---	---	---	---	PASS
P4HA1	5033	broad.mit.edu	37	10	74831843	74831843	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:74831843C>T	uc010qka.1	-	5	603	c.269G>A	c.(268-270)CGT>CAT	p.R90H	P4HA1_uc001jtg.2_Missense_Mutation_p.R90H|P4HA1_uc001jth.2_Missense_Mutation_p.R90H|P4HA1_uc010qkb.1_Missense_Mutation_p.R90H|P4HA1_uc001jti.2_RNA	NM_001142595	NP_001136067	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha I subunit isoform 2	90						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			ovary(1)	1	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	AGTATTCAGACGTTTCATTAA	0.408													14	61	---	---	---	---	PASS
NRG3	10718	broad.mit.edu	37	10	84745267	84745267	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:84745267C>A	uc001kco.2	+	9	2024	c.1997C>A	c.(1996-1998)GCC>GAC	p.A666D	NRG3_uc010qlz.1_Missense_Mutation_p.A665D|NRG3_uc001kcp.2_Missense_Mutation_p.A469D|NRG3_uc001kcq.2_Missense_Mutation_p.A316D|NRG3_uc001kcr.2_Missense_Mutation_p.A340D	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	690	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		GAAAACACAGCCTTTCTCCCC	0.493													5	37	---	---	---	---	PASS
CUTC	51076	broad.mit.edu	37	10	101503802	101503802	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:101503802C>G	uc001kqd.3	+	5	560	c.412C>G	c.(412-414)CGC>GGC	p.R138G	CUTC_uc010qpk.1_Missense_Mutation_p.R138G|CUTC_uc001kqe.3_RNA	NM_015960	NP_057044	Q9NTM9	CUTC_HUMAN	cutC copper transporter homolog	138					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		AGCTATTTGCCGCCCTCTGCC	0.338													5	30	---	---	---	---	PASS
SH3PXD2A	9644	broad.mit.edu	37	10	105372887	105372887	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:105372887C>A	uc001kxj.1	-	11	1037	c.897G>T	c.(895-897)CTG>CTT	p.L299L	SH3PXD2A_uc010qqr.1_Silent_p.L189L|SH3PXD2A_uc010qqs.1_Silent_p.L134L|SH3PXD2A_uc010qqt.1_Silent_p.L176L|SH3PXD2A_uc009xxn.1_Silent_p.L134L|SH3PXD2A_uc010qqu.1_Silent_p.L242L	NM_014631	NP_055446	Q5TCZ1	SPD2A_HUMAN	SH3 multiple domains 1	327					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding				0		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		TCCGGGTTGGCAGGTCATCCT	0.557													36	29	---	---	---	---	PASS
COL17A1	1308	broad.mit.edu	37	10	105807833	105807833	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:105807833G>A	uc001kxr.2	-	30	2426	c.2257C>T	c.(2257-2259)CCA>TCA	p.P753S		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	753	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CAACCTCTTGGGCCTTGGTGT	0.582													29	117	---	---	---	---	PASS
FAM160B1	57700	broad.mit.edu	37	10	116595985	116595985	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:116595985C>A	uc001lcb.2	+	5	837	c.502C>A	c.(502-504)CTG>ATG	p.L168M	FAM160B1_uc001lcc.2_Missense_Mutation_p.L168M	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	168										lung(1)	1						GGACCCCTACCTGGTTAACTT	0.328													6	124	---	---	---	---	PASS
TNNI2	7136	broad.mit.edu	37	11	1862288	1862288	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:1862288G>T	uc010qxe.1	+	5	326	c.304G>T	c.(304-306)GAT>TAT	p.D102Y	TNNI2_uc010qxc.1_Missense_Mutation_p.D100Y|TNNI2_uc010qxd.1_Missense_Mutation_p.D100Y	NM_001145841	NP_001139313	P48788	TNNI2_HUMAN	fast-twitch skeletal muscle troponin I isoform	102	Involved in binding TNC and actin.				muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding				0		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GAAGCTATTTGATCTGCGGGG	0.592													10	4	---	---	---	---	PASS
TNNT3	7140	broad.mit.edu	37	11	1959678	1959678	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:1959678G>C	uc001luu.3	+	16	945	c.733G>C	c.(733-735)GCT>CCT	p.A245P	TNNT3_uc001luw.3_Missense_Mutation_p.A237P|TNNT3_uc001luo.3_Missense_Mutation_p.A237P|TNNT3_uc001lup.3_Missense_Mutation_p.A243P|TNNT3_uc001luq.3_Missense_Mutation_p.A237P|TNNT3_uc001lur.2_Missense_Mutation_p.A237P|TNNT3_uc010qxf.1_Missense_Mutation_p.A243P|TNNT3_uc010qxg.1_Missense_Mutation_p.A177P	NM_006757	NP_006748	P45378	TNNT3_HUMAN	troponin T3, skeletal, fast isoform 1	256					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			ovary(1)	1		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		CAGCAAGAAGGCTGGGACCCC	0.662													4	26	---	---	---	---	PASS
OR52B4	143496	broad.mit.edu	37	11	4388990	4388990	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:4388990G>A	uc010qye.1	-	1	536	c.536C>T	c.(535-537)ACC>ATC	p.T179I		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTCACAAAAGGTGTGTGGAAT	0.348													43	14	---	---	---	---	PASS
OR10A4	283297	broad.mit.edu	37	11	6898522	6898522	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:6898522T>A	uc010rat.1	+	1	644	c.644T>A	c.(643-645)ATC>AAC	p.I215N		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TTCTTGCTGATCCTGGGATCC	0.522													34	19	---	---	---	---	PASS
PDE3B	5140	broad.mit.edu	37	11	14666331	14666331	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:14666331T>C	uc001mln.2	+	1	1063	c.710T>C	c.(709-711)CTC>CCC	p.L237P	PDE3B_uc001mlm.2_Missense_Mutation_p.L237P|PDE3B_uc010rcr.1_Missense_Mutation_p.L237P|PSMA1_uc001mll.2_5'Flank	NM_000922	NP_000913	Q13370	PDE3B_HUMAN	phosphodiesterase 3B	237	Helical; (Potential).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding				0						TTCACCAGCCTCGGGTCGCTG	0.692													7	2	---	---	---	---	PASS
LDHC	3948	broad.mit.edu	37	11	18456380	18456380	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:18456380G>A	uc001mon.3	+	5	624	c.512G>A	c.(511-513)CGT>CAT	p.R171H	LDHC_uc001mom.3_Missense_Mutation_p.R171H|LDHC_uc009yhp.2_Missense_Mutation_p.R171H|LDHC_uc001moo.3_Missense_Mutation_p.R55H|LDHC_uc009yhq.2_RNA|LDHC_uc009yhr.2_Missense_Mutation_p.R55H	NM_017448	NP_059144	P07864	LDHC_HUMAN	L-lactate dehydrogenase C	171					glycolysis	cytoplasm	binding|L-lactate dehydrogenase activity				0					NADH(DB00157)	GCCCGTTTCCGTTACCTAATT	0.373													42	23	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	11	30926574	30926574	+	RNA	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:30926574T>C	uc001mss.1	-	9		c.1345A>G			uc009yjk.1_Missense_Mutation_p.I862M|uc009yjj.1_RNA					Homo sapiens mRNA for KIAA1493 protein, partial cds.																		TGTATGCAATTATTTTCACTG	0.458													7	45	---	---	---	---	PASS
TSPAN18	90139	broad.mit.edu	37	11	44939553	44939553	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:44939553G>T	uc001mye.3	+	4	450	c.289G>T	c.(289-291)GCA>TCA	p.A97S	TP53I11_uc001myf.1_Intron|TSPAN18_uc001myg.2_Missense_Mutation_p.A97S	NM_130783	NP_570139	Q96SJ8	TSN18_HUMAN	tetraspanin 18 isoform 2	97	Helical; (Potential).					integral to membrane					0						CATCTTCCTGGCAGAGCTCTC	0.582													29	18	---	---	---	---	PASS
RAPSN	5913	broad.mit.edu	37	11	47464329	47464329	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:47464329G>T	uc001nfi.1	-	3	783	c.569C>A	c.(568-570)GCA>GAA	p.A190E	RAPSN_uc001nfj.1_Missense_Mutation_p.A190E|RAPSN_uc009yls.1_Missense_Mutation_p.A190E	NM_005055	NP_005046	Q13702	RAPSN_HUMAN	43 kD receptor-associated protein of the synapse	190	TPR 4.				synaptic transmission, cholinergic	cell junction|cytoskeleton|postsynaptic membrane	acetylcholine receptor binding|zinc ion binding			ovary(1)	1						GACAAGCTCTGCCGCCTTGCA	0.612													4	70	---	---	---	---	PASS
OR4A15	81328	broad.mit.edu	37	11	55136154	55136154	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:55136154C>A	uc010rif.1	+	1	795	c.795C>A	c.(793-795)TTC>TTA	p.F265L		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	265	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GAAAAGCTTTCTACACCTGTG	0.428													66	30	---	---	---	---	PASS
OR4C15	81309	broad.mit.edu	37	11	55322087	55322087	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:55322087T>C	uc010rig.1	+	1	305	c.305T>C	c.(304-306)CTC>CCC	p.L102P		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	48	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GTAACCATTCTCAGCAGCCCT	0.428										HNSCC(20;0.049)			59	32	---	---	---	---	PASS
OR5J2	282775	broad.mit.edu	37	11	55944825	55944825	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:55944825C>A	uc010rjb.1	+	1	732	c.732C>A	c.(730-732)CAC>CAA	p.H244Q		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	244	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					GTGCCTCTCACCTGACTGCTG	0.443													53	19	---	---	---	---	PASS
OR5T1	390155	broad.mit.edu	37	11	56043229	56043229	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:56043229C>A	uc001nio.1	+	1	115	c.115C>A	c.(115-117)CTA>ATA	p.L39I		NM_001004745	NP_001004745	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)	3	Esophageal squamous(21;0.00448)					GCAAGTCTTCCTATTTTTATT	0.333													5	61	---	---	---	---	PASS
OR8J1	219477	broad.mit.edu	37	11	56128066	56128066	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:56128066T>G	uc010rjh.1	+	1	344	c.344T>G	c.(343-345)CTG>CGG	p.L115R		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GTAATCATGCTGGCTTTGATG	0.473													50	31	---	---	---	---	PASS
OR8J1	219477	broad.mit.edu	37	11	56128067	56128067	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:56128067G>T	uc010rjh.1	+	1	345	c.345G>T	c.(343-345)CTG>CTT	p.L115L		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TAATCATGCTGGCTTTGATGG	0.468													47	34	---	---	---	---	PASS
FAM111B	374393	broad.mit.edu	37	11	58893299	58893299	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:58893299A>G	uc001nnl.2	+	4	1972	c.1729A>G	c.(1729-1731)ATT>GTT	p.I577V	FAM111B_uc001nnm.2_Missense_Mutation_p.I547V|FAM111B_uc010rko.1_Missense_Mutation_p.I547V	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	577							catalytic activity			ovary(2)	2						GATTTATTTAATTGGTCATCC	0.363													9	42	---	---	---	---	PASS
ZBTB3	79842	broad.mit.edu	37	11	62520528	62520528	+	Silent	SNP	G	A	A	rs148738930		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:62520528G>A	uc001nuz.2	-	2	881	c.759C>T	c.(757-759)GAC>GAT	p.D253D		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	253	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						GATGTGGTGCGTCAACCTCCA	0.552													5	21	---	---	---	---	PASS
RPS6KA4	8986	broad.mit.edu	37	11	64126861	64126861	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:64126861G>T	uc001oae.2	+	2	150	c.67G>T	c.(67-69)GGG>TGG	p.G23W	RPS6KA4_uc001oad.2_Missense_Mutation_p.G23W|RPS6KA4_uc010rnl.1_5'UTR|RPS6KA4_uc001oaf.2_Missense_Mutation_p.G23W|RPS6KA4_uc009ypp.2_Missense_Mutation_p.G23W	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	23					axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						CAACCTGACCGGGCACGAGGA	0.711													3	4	---	---	---	---	PASS
MUS81	80198	broad.mit.edu	37	11	65632525	65632525	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:65632525G>T	uc001ofv.3	+	13	1663	c.1310G>T	c.(1309-1311)GGG>GTG	p.G437V	MUS81_uc001ofw.3_Intron|MUS81_uc001ofx.3_5'UTR	NM_025128	NP_079404	Q96NY9	MUS81_HUMAN	MUS81 endonuclease homolog	437					DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding				0				READ - Rectum adenocarcinoma(159;0.166)		GGAACCCCTGGGAACCCTGAA	0.602								Homologous_recombination					6	151	---	---	---	---	PASS
C2CD3	26005	broad.mit.edu	37	11	73768589	73768589	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:73768589C>A	uc001ouu.2	-	25	5179	c.4952G>T	c.(4951-4953)GGG>GTG	p.G1651V	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1651	C2 2.					centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					CAAGGGGCTCCCTGAAATAGA	0.458													6	60	---	---	---	---	PASS
SFRS2B	10929	broad.mit.edu	37	11	94800939	94800939	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:94800939C>A	uc001pff.2	+	2	885	c.550C>A	c.(550-552)CGC>AGC	p.R184S	SFRS2B_uc001pfg.1_5'Flank	NM_032102	NP_115285	Q9BRL6	SRSF8_HUMAN	splicing factor, arginine/serine-rich 2B	184	Arg-rich.				mRNA processing|RNA splicing	nucleus	nucleotide binding|RNA binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CAGGGAATCTCGCTACGGCGG	0.567													5	61	---	---	---	---	PASS
DSCAML1	57453	broad.mit.edu	37	11	117321399	117321399	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:117321399C>T	uc001prh.1	-	20	3756	c.3754G>A	c.(3754-3756)GGT>AGT	p.G1252S		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1192	Extracellular (Potential).|Fibronectin type-III 4.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GCAGGGGGACCTGGAACTGAG	0.567													4	22	---	---	---	---	PASS
OR10S1	219873	broad.mit.edu	37	11	123848350	123848350	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:123848350G>A	uc001pzm.1	-	1	49	c.49C>T	c.(49-51)CCC>TCC	p.P17S		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GTCTGGTTGGGGTTCTCCGTT	0.478													42	18	---	---	---	---	PASS
OR10G9	219870	broad.mit.edu	37	11	123893737	123893737	+	Silent	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:123893737C>G	uc010sad.1	+	1	18	c.18C>G	c.(16-18)CTC>CTG	p.L6L		NM_001001953	NP_001001953	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AGACCAGCCTCGTGACAGCGT	0.532													61	38	---	---	---	---	PASS
OR8D2	283160	broad.mit.edu	37	11	124189744	124189744	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:124189744G>T	uc010sah.1	-	1	350	c.350C>A	c.(349-351)GCC>GAC	p.A117D		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		ATATTCCATGGCTGTCAGAAG	0.403													9	45	---	---	---	---	PASS
FLI1	2313	broad.mit.edu	37	11	128628020	128628020	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:128628020C>A	uc010sbu.1	+	2	370	c.29C>A	c.(28-30)TCG>TAG	p.S10*	FLI1_uc010sbt.1_5'UTR|FLI1_uc010sbv.1_5'UTR|FLI1_uc009zci.2_5'UTR|FLI1_uc001qen.2_5'UTR	NM_002017	NP_002008	Q01543	FLI1_HUMAN	Friend leukemia virus integration 1	10					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2266)	bone(2210)|soft_tissue(48)|autonomic_ganglia(4)|central_nervous_system(4)|lung(3)|ovary(2)|pancreas(2)	2273	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GAGGCTCTGTCGGTGGTGAGC	0.612			T	EWSR1	Ewing sarcoma								8	2	---	---	---	---	PASS
SNX19	399979	broad.mit.edu	37	11	130781571	130781571	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr11:130781571C>A	uc001qgk.3	-	2	2318	c.1770G>T	c.(1768-1770)CAG>CAT	p.Q590H	SNX19_uc010sce.1_5'UTR|SNX19_uc010scf.1_Missense_Mutation_p.Q33H|SNX19_uc010scg.1_5'UTR|SNX19_uc001qgl.3_Missense_Mutation_p.Q590H|SNX19_uc009zcx.1_RNA	NM_014758	NP_055573	Q92543	SNX19_HUMAN	sorting nexin 19	590	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			ovary(2)|lung(2)	4	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		CCAGACGGGTCTGCAGATTCA	0.552													31	16	---	---	---	---	PASS
WNK1	65125	broad.mit.edu	37	12	988914	988914	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:988914A>G	uc001qio.3	+	11	3056	c.2549A>G	c.(2548-2550)CAT>CGT	p.H850R	WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	850					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			TCAACTCCTCATGTGTCTACG	0.537													53	53	---	---	---	---	PASS
WNK1	65125	broad.mit.edu	37	12	1005592	1005592	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:1005592C>G	uc001qio.3	+	24	6446	c.5939C>G	c.(5938-5940)CCT>CGT	p.P1980R	WNK1_uc001qip.3_Missense_Mutation_p.P1732R|WNK1_uc001qir.3_Missense_Mutation_p.P1153R	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1980					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GCATCTCCTCCTTTTATGGAT	0.448													97	79	---	---	---	---	PASS
PRMT8	56341	broad.mit.edu	37	12	3701428	3701428	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:3701428G>T	uc001qmf.2	+	9	1378	c.1011G>T	c.(1009-1011)CAG>CAT	p.Q337H	PRMT8_uc009zed.2_Missense_Mutation_p.Q328H|PRMT8_uc001qmg.2_Missense_Mutation_p.Q151H|PRMT8_uc001qmh.2_RNA	NM_019854	NP_062828	Q9NR22	ANM8_HUMAN	HMT1 hnRNP methyltransferase-like 4	337					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			ovary(3)|central_nervous_system(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			ACTGGAAGCAGACCGTCTTCT	0.537													88	81	---	---	---	---	PASS
ANO2	57101	broad.mit.edu	37	12	5744332	5744332	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:5744332C>A	uc001qnm.2	-	17	1874	c.1802G>T	c.(1801-1803)TGG>TTG	p.W601L		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	606	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						TTTGGTGAGCCACTTGGCCAC	0.498													4	23	---	---	---	---	PASS
GRIN2B	2904	broad.mit.edu	37	12	13717533	13717533	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:13717533C>T	uc001rbt.2	-	13	2818	c.2639G>A	c.(2638-2640)CGC>CAC	p.R880H		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	880	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TACAGACTGGCGCTCCTCGAT	0.537													12	89	---	---	---	---	PASS
GRIN2B	2904	broad.mit.edu	37	12	13768055	13768055	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:13768055G>T	uc001rbt.2	-	7	1826	c.1647C>A	c.(1645-1647)GCC>GCA	p.A549A		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	549	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TACCTAAGAAGGCAGAAGGTG	0.502													6	101	---	---	---	---	PASS
PTPRO	5800	broad.mit.edu	37	12	15669838	15669838	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:15669838A>G	uc001rcv.1	+	9	1901	c.1727A>G	c.(1726-1728)GAG>GGG	p.E576G	PTPRO_uc001rcw.1_Missense_Mutation_p.E576G|PTPRO_uc001rcu.1_Missense_Mutation_p.E576G	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	576	Fibronectin type-III 6.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				ATGACATCAGAGTGGACCACC	0.448													14	84	---	---	---	---	PASS
PIK3C2G	5288	broad.mit.edu	37	12	18691185	18691185	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:18691185G>T	uc001rdt.2	+	24	3412	c.3296G>T	c.(3295-3297)TGC>TTC	p.C1099F	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.C1140F|PIK3C2G_uc010sic.1_Missense_Mutation_p.C918F	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	1099	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				GTGGAACTTTGCTGTCGTGCT	0.383													37	31	---	---	---	---	PASS
PLEKHA5	54477	broad.mit.edu	37	12	19511295	19511295	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:19511295A>G	uc001reb.2	+	21	2860	c.2774A>G	c.(2773-2775)AAT>AGT	p.N925S	PLEKHA5_uc010sie.1_Missense_Mutation_p.N1086S|PLEKHA5_uc001rea.2_Missense_Mutation_p.N983S|PLEKHA5_uc009zin.2_Missense_Mutation_p.N683S|PLEKHA5_uc010sif.1_Missense_Mutation_p.N914S|PLEKHA5_uc010sig.1_Missense_Mutation_p.N907S|PLEKHA5_uc010sih.1_Missense_Mutation_p.N880S|PLEKHA5_uc001rec.1_Missense_Mutation_p.N734S|PLEKHA5_uc009zio.2_Missense_Mutation_p.N191S	NM_019012	NP_061885	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A	925							1-phosphatidylinositol binding|protein binding			ovary(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					AAAGGGTTAAATGTTATCGGT	0.398													8	48	---	---	---	---	PASS
PDE3A	5139	broad.mit.edu	37	12	20766412	20766412	+	Silent	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:20766412C>G	uc001reh.1	+	3	1069	c.1047C>G	c.(1045-1047)GTC>GTG	p.V349V		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	349					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.V349I(1)		ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	ACATCGCCGTCATGGGCGAGG	0.522													9	60	---	---	---	---	PASS
PDE3A	5139	broad.mit.edu	37	12	20766502	20766502	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:20766502C>G	uc001reh.1	+	3	1159	c.1137C>G	c.(1135-1137)AAC>AAG	p.N379K		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	379					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CCGTGAGCAACTTGCTCAGCA	0.552													18	65	---	---	---	---	PASS
SLCO1B3	28234	broad.mit.edu	37	12	21011372	21011372	+	Splice_Site	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:21011372G>T	uc001rek.2	+	4	353	c.227_splice	c.e4-1	p.G76_splice	SLCO1B3_uc001rel.2_Splice_Site_p.G76_splice|SLCO1B3_uc010sil.1_Splice_Site_p.G76_splice|LST-3TM12_uc010sim.1_Splice_Site_p.G76_splice	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,						bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					TTTTTTTCTAGGAAATTTGCT	0.274													17	10	---	---	---	---	PASS
LST-3TM12	338821	broad.mit.edu	37	12	21207483	21207483	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:21207483G>T	uc010sin.1	+	10	1454	c.1454G>T	c.(1453-1455)AGG>ATG	p.R485M	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Missense_Mutation_p.R532M	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	485						membrane	transporter activity				0						GCTTGTACAAGGAAATCTTAC	0.393													25	15	---	---	---	---	PASS
OVCH1	341350	broad.mit.edu	37	12	29648370	29648370	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:29648370G>A	uc001rix.1	-	4	302	c.302C>T	c.(301-303)ACT>ATT	p.T101I		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	101	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					AGAAGTCACAGTTATATTCTT	0.368													11	37	---	---	---	---	PASS
C12orf35	55196	broad.mit.edu	37	12	32137484	32137484	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:32137484G>T	uc001rks.2	+	4	4009	c.3595G>T	c.(3595-3597)GAG>TAG	p.E1199*	C12orf35_uc001rkt.2_5'Flank	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1199										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			CTCATCTTCAGAGGAAGAGAA	0.418													15	59	---	---	---	---	PASS
ABCD2	225	broad.mit.edu	37	12	40013232	40013232	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:40013232G>T	uc001rmb.2	-	1	612	c.186C>A	c.(184-186)AAC>AAA	p.N62K		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	62	Interaction with PEX19.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						GTATTTCTGTGTTCTCTGCAG	0.448													12	54	---	---	---	---	PASS
MLL2	8085	broad.mit.edu	37	12	49425673	49425673	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:49425673C>T	uc001rta.3	-	39	12815	c.12815G>A	c.(12814-12816)GGC>GAC	p.G4272D		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4272	Pro-rich.|Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CTGGAGGGGGCCTGTCTGTGG	0.687			N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			6	8	---	---	---	---	PASS
PRPH	5630	broad.mit.edu	37	12	49691473	49691473	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:49691473G>A	uc001rtu.2	+	7	1306	c.1231G>A	c.(1231-1233)GTC>ATC	p.V411I		NM_006262	NP_006253	P41219	PERI_HUMAN	peripherin	411	Tail.						structural molecule activity				0						CTCCGTGCCCGTCCATTCTTT	0.428													6	45	---	---	---	---	PASS
KCNH3	23416	broad.mit.edu	37	12	49934881	49934881	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:49934881G>T	uc001ruh.1	+	2	536	c.276G>T	c.(274-276)GAG>GAT	p.E92D	KCNH3_uc010smj.1_Missense_Mutation_p.E32D	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	92	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						AGCACAAGGAGTTCAAGGCTG	0.632													12	13	---	---	---	---	PASS
TMEM5	10329	broad.mit.edu	37	12	64199137	64199137	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:64199137G>C	uc001srq.1	+	5	971	c.867G>C	c.(865-867)TTG>TTC	p.L289F	TMEM5_uc001srr.1_Missense_Mutation_p.L186F|TMEM5_uc001srs.1_Missense_Mutation_p.L29F	NM_014254	NP_055069	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	289	Extracellular (Potential).					integral to plasma membrane					0		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		TGAACATTTTGAAAAAAGATG	0.358													12	59	---	---	---	---	PASS
DYRK2	8445	broad.mit.edu	37	12	68051114	68051114	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:68051114A>G	uc001str.3	+	3	829	c.427A>G	c.(427-429)ATG>GTG	p.M143V	DYRK2_uc001sts.3_Missense_Mutation_p.M70V	NM_006482	NP_006473	Q92630	DYRK2_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	143					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of glycogen biosynthetic process|smoothened signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|manganese ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(2)|breast(1)|central_nervous_system(1)	4			Lung(24;6.81e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(7;0.000573)		TCTAAAGTCCATGGAAGGCAT	0.527													8	10	---	---	---	---	PASS
EEA1	8411	broad.mit.edu	37	12	93221723	93221723	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:93221723C>A	uc001tck.2	-	12	1634	c.1369G>T	c.(1369-1371)GAT>TAT	p.D457Y		NM_003566	NP_003557	Q15075	EEA1_HUMAN	early endosome antigen 1, 162kD	457	Gln/Glu/Lys-rich.|Potential.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			ovary(2)|skin(1)	3						AGTTGTAAATCAGCCACTTGT	0.403													10	72	---	---	---	---	PASS
ANO4	121601	broad.mit.edu	37	12	101514370	101514370	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:101514370A>G	uc010svm.1	+	26	3215	c.2643A>G	c.(2641-2643)CTA>CTG	p.L881L	ANO4_uc001thw.2_Silent_p.L846L|ANO4_uc001thx.2_Silent_p.L881L|ANO4_uc001thy.2_Silent_p.L401L	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	881	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GGCATGTCCTAGCTGCTCGAT	0.408										HNSCC(74;0.22)			9	13	---	---	---	---	PASS
MYBPC1	4604	broad.mit.edu	37	12	102045125	102045125	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:102045125C>A	uc001tii.2	+	14	1507	c.1405C>A	c.(1405-1407)CTA>ATA	p.L469I	MYBPC1_uc001tif.1_Missense_Mutation_p.L482I|MYBPC1_uc001tig.2_Missense_Mutation_p.L494I|MYBPC1_uc010svq.1_Missense_Mutation_p.L456I|MYBPC1_uc001tih.2_Missense_Mutation_p.L494I|MYBPC1_uc001tij.2_Missense_Mutation_p.L469I|MYBPC1_uc010svr.1_Missense_Mutation_p.L469I|MYBPC1_uc010svs.1_Missense_Mutation_p.L469I|MYBPC1_uc010svt.1_Missense_Mutation_p.L457I|MYBPC1_uc010svu.1_Missense_Mutation_p.L450I|MYBPC1_uc001tik.2_Missense_Mutation_p.L443I	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	469	Ig-like C2-type 4.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						TAAAAATGGCCTACCTGTTCA	0.453													6	172	---	---	---	---	PASS
HCFC2	29915	broad.mit.edu	37	12	104487333	104487333	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:104487333A>G	uc001tkj.3	+	10	1557	c.1454A>G	c.(1453-1455)AAA>AGA	p.K485R	HCFC2_uc009zul.2_RNA	NM_013320	NP_037452	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	485					regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			ovary(2)|central_nervous_system(1)	3						ATGCTAAGGAAAAATGAAGGT	0.318													7	34	---	---	---	---	PASS
IFT81	28981	broad.mit.edu	37	12	110565897	110565897	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:110565897G>A	uc001tqi.2	+	3	321	c.191G>A	c.(190-192)CGA>CAA	p.R64Q	IFT81_uc001tqh.2_Missense_Mutation_p.R64Q|IFT81_uc001tqj.2_RNA|IFT81_uc001tqg.2_Missense_Mutation_p.R64Q	NM_001143779	NP_001137251	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81-like isoform 1	64					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				ovary(1)	1						ACAGCCAAACGAATGTTGAGC	0.343													6	51	---	---	---	---	PASS
C12orf51	283450	broad.mit.edu	37	12	112673472	112673472	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:112673472C>T	uc009zwc.2	-	29	4313	c.4295G>A	c.(4294-4296)CGG>CAG	p.R1432Q		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						CAGCGCCGCCCGGCACAGCTG	0.587													16	29	---	---	---	---	PASS
OAS2	4939	broad.mit.edu	37	12	113435444	113435444	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:113435444A>G	uc001tuj.2	+	4	887	c.747A>G	c.(745-747)AGA>AGG	p.R249R	OAS2_uc001tui.1_Silent_p.R249R	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	249	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						AAGGCGTCAGAACCGTACTGG	0.498													8	28	---	---	---	---	PASS
TMEM132D	121256	broad.mit.edu	37	12	130184572	130184572	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:130184572G>A	uc009zyl.1	-	2	1079	c.751C>T	c.(751-753)CGG>TGG	p.R251W		NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	251	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TGGCCTGTCCGGATCCCATTG	0.617													24	21	---	---	---	---	PASS
POLE	5426	broad.mit.edu	37	12	133220500	133220500	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:133220500C>T	uc001uks.1	-	33	4257	c.4213G>A	c.(4213-4215)GAC>AAC	p.D1405N	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Missense_Mutation_p.D209N|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.D1378N	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1405					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		TGGTACATGTCCTCTGGCACT	0.537								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					15	55	---	---	---	---	PASS
ATP8A2	51761	broad.mit.edu	37	13	26436473	26436473	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr13:26436473C>T	uc001uqk.2	+	33	3252	c.3110C>T	c.(3109-3111)ACC>ATC	p.T1037I	ATP8A2_uc010tdi.1_Missense_Mutation_p.T972I|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.T587I	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	997	Helical; (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGCATGCTGACCTGGCTGGTG	0.532													26	10	---	---	---	---	PASS
SLC7A1	6541	broad.mit.edu	37	13	30091888	30091888	+	Silent	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr13:30091888G>C	uc001uso.2	-	10	1719	c.1332C>G	c.(1330-1332)GCC>GCG	p.A444A		NM_003045	NP_003036	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid	444	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity				0		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	CGGAAGTACTGGCCATCTGGT	0.502													6	41	---	---	---	---	PASS
POSTN	10631	broad.mit.edu	37	13	38143490	38143490	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr13:38143490C>T	uc001uwo.3	-	21	2496	c.2378G>A	c.(2377-2379)GGT>GAT	p.G793D	POSTN_uc010tet.1_Missense_Mutation_p.G294D|POSTN_uc001uwp.3_Missense_Mutation_p.G736D|POSTN_uc001uwr.2_Intron|POSTN_uc001uwq.2_Intron|POSTN_uc010teu.1_Missense_Mutation_p.G766D|POSTN_uc010tev.1_Missense_Mutation_p.G706D|POSTN_uc010tew.1_Intron	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	793					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		ACCATCACCACCTTCAATGAA	0.363													23	11	---	---	---	---	PASS
NHLRC3	387921	broad.mit.edu	37	13	39612853	39612853	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr13:39612853G>A	uc001uxc.2	+	1	399	c.77G>A	c.(76-78)GGC>GAC	p.G26D	C13orf23_uc001uwy.2_5'Flank|C13orf23_uc001uwz.2_5'Flank|NHLRC3_uc001uxa.1_Missense_Mutation_p.G26D|NHLRC3_uc001uxb.1_Missense_Mutation_p.G26D|NHLRC3_uc001uxd.2_Missense_Mutation_p.G26D|NHLRC3_uc001uxe.2_Intron	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	26						extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		CGTTTTTGTGGCTCTCCAGTG	0.587													14	43	---	---	---	---	PASS
OR4M1	441670	broad.mit.edu	37	14	20249004	20249004	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:20249004G>A	uc010tku.1	+	1	523	c.523G>A	c.(523-525)GAC>AAC	p.D175N		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAATGAGTTAGACAGTTACTT	0.488													8	158	---	---	---	---	PASS
OR4K1	79544	broad.mit.edu	37	14	20403995	20403995	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:20403995C>T	uc001vwj.1	+	1	170	c.170C>T	c.(169-171)TCT>TTT	p.S57F		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	57	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CATTTGAACTCTCCTATGTAC	0.363													81	95	---	---	---	---	PASS
SUPT16H	11198	broad.mit.edu	37	14	21831050	21831050	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:21831050T>C	uc001wao.2	-	14	1907	c.1568A>G	c.(1567-1569)CAT>CGT	p.H523R		NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	523					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		TTCCCGAATATGTGGTTCCTT	0.408													54	40	---	---	---	---	PASS
RNF31	55072	broad.mit.edu	37	14	24618034	24618034	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:24618034C>G	uc001wmn.1	+	5	829	c.580C>G	c.(580-582)CCC>GCC	p.P194A	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_Missense_Mutation_p.P43A|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.P9A|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	194	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		AGAATTTGACCCCCTATTGAG	0.473													23	132	---	---	---	---	PASS
SSTR1	6751	broad.mit.edu	37	14	38679162	38679162	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:38679162C>A	uc001wul.1	+	3	1185	c.568C>A	c.(568-570)CTG>ATG	p.L190M	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	190	Helical; Name=4; (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GCTCGTCATCCTGCCCATCGT	0.662													18	29	---	---	---	---	PASS
LRFN5	145581	broad.mit.edu	37	14	42356638	42356638	+	Silent	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:42356638T>C	uc001wvm.2	+	3	2008	c.810T>C	c.(808-810)ACT>ACC	p.T270T	LRFN5_uc010ana.2_Silent_p.T270T	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	270	Extracellular (Potential).|LRRCT.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CACTTTTAACTGGCCGCTACT	0.468										HNSCC(30;0.082)			15	90	---	---	---	---	PASS
LRFN5	145581	broad.mit.edu	37	14	42356639	42356639	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:42356639G>T	uc001wvm.2	+	3	2009	c.811G>T	c.(811-813)GGC>TGC	p.G271C	LRFN5_uc010ana.2_Missense_Mutation_p.G271C	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	271	Extracellular (Potential).|LRRCT.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		ACTTTTAACTGGCCGCTACTT	0.473										HNSCC(30;0.082)			18	88	---	---	---	---	PASS
FAM179B	23116	broad.mit.edu	37	14	45540921	45540921	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:45540921A>T	uc001wvv.2	+	18	5026	c.4817A>T	c.(4816-4818)TAC>TTC	p.Y1606F	FAM179B_uc001wvw.2_Missense_Mutation_p.Y1659F|FAM179B_uc010anc.2_RNA	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	1606							binding			skin(2)|upper_aerodigestive_tract(1)	3						TTAGACAATTACTTACTTCTA	0.313													19	27	---	---	---	---	PASS
ARID4A	5926	broad.mit.edu	37	14	58817845	58817845	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:58817845G>T	uc001xdp.2	+	16	1713	c.1459G>T	c.(1459-1461)GAG>TAG	p.E487*	ARID4A_uc001xdo.2_Nonsense_Mutation_p.E487*|ARID4A_uc001xdq.2_Nonsense_Mutation_p.E487*|ARID4A_uc010apg.1_Nonsense_Mutation_p.E165*	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	487					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						AATTGAAGAAGAGAAAACAGA	0.328													5	78	---	---	---	---	PASS
DCAF4	26094	broad.mit.edu	37	14	73425438	73425438	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:73425438G>T	uc001xng.2	+	14	1633	c.1413G>T	c.(1411-1413)CGG>CGT	p.R471R	DCAF4_uc001xnj.2_Silent_p.R465R|DCAF4_uc010ttr.1_Silent_p.R450R|DCAF4_uc001xnh.2_Silent_p.R371R|DCAF4_uc010tts.1_Silent_p.R411R|DCAF4_uc010ttt.1_Silent_p.R257R|DCAF4_uc001xni.2_Silent_p.R301R	NM_015604	NP_056419	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4 isoform 1	471						CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)|skin(1)	3						TCTCGTCGCGGCTGGGGGGCT	0.647													14	37	---	---	---	---	PASS
C14orf115	55237	broad.mit.edu	37	14	74824319	74824319	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:74824319C>A	uc001xpw.3	+	2	1024	c.833C>A	c.(832-834)CCT>CAT	p.P278H		NM_018228	NP_060698	Q9H8Y1	VRTN_HUMAN	hypothetical protein LOC55237	278					transposition, DNA-mediated		DNA binding|transposase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00147)		AACCGTGAACCTGGCCTCAGC	0.652													25	17	---	---	---	---	PASS
KIAA1737	85457	broad.mit.edu	37	14	77580133	77580133	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:77580133G>T	uc001xtd.2	+	4	851	c.672G>T	c.(670-672)GAG>GAT	p.E224D	KIAA1737_uc001xtc.1_Missense_Mutation_p.E126D	NM_033426	NP_219494	Q9C0C6	K1737_HUMAN	KIAA1737 protein	224											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0284)		AACTTGCCGAGGACTCAGCTC	0.602													5	58	---	---	---	---	PASS
FLRT2	23768	broad.mit.edu	37	14	86088550	86088550	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:86088550A>T	uc001xvr.2	+	2	1459	c.692A>T	c.(691-693)AAG>ATG	p.K231M	FLRT2_uc010atd.2_Missense_Mutation_p.K231M	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	231	Extracellular (Potential).|LRR 8.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CATCTCACCAAGCTCAAGGAA	0.522													16	90	---	---	---	---	PASS
PPP4R4	57718	broad.mit.edu	37	14	94712742	94712742	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:94712742C>A	uc001ycs.1	+	14	1631	c.1477C>A	c.(1477-1479)CGA>AGA	p.R493R		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	493						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						TGCTGAACAGCGAGCTGCAGC	0.403													15	45	---	---	---	---	PASS
ADAM6	8755	broad.mit.edu	37	14	107113932	107113932	+	RNA	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:107113932G>T	uc010tyt.1	-	84		c.3941C>A								Parts of antibodies, mostly variable regions.												0						CGGACCCAGTGCATAGCATAG	0.547													71	179	---	---	---	---	PASS
ADAM6	8755	broad.mit.edu	37	14	107113933	107113933	+	RNA	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr14:107113933C>T	uc010tyt.1	-	84		c.3940G>A								Parts of antibodies, mostly variable regions.												0						GGACCCAGTGCATAGCATAGC	0.547													69	179	---	---	---	---	PASS
GABRB3	2562	broad.mit.edu	37	15	26812801	26812801	+	Silent	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr15:26812801A>T	uc001zaz.2	-	7	904	c.762T>A	c.(760-762)TCT>TCA	p.S254S	GABRB3_uc010uae.1_Silent_p.S169S|GABRB3_uc001zba.2_Silent_p.S254S|GABRB3_uc001zbb.2_Silent_p.S310S	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	254	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTATCAGTATAGAGGGCATAT	0.423													19	35	---	---	---	---	PASS
SLC27A2	11001	broad.mit.edu	37	15	50526174	50526174	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr15:50526174G>T	uc001zxw.2	+	9	1897	c.1665G>T	c.(1663-1665)AGG>AGT	p.R555S	SLC27A2_uc010bes.2_Missense_Mutation_p.R502S|SLC27A2_uc001zxx.2_Missense_Mutation_p.R320S	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid	555	Cytoplasmic (Potential).				bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		GTTATGCAAGGCCCCGGTTTC	0.433													39	16	---	---	---	---	PASS
CCPG1	9236	broad.mit.edu	37	15	55652654	55652654	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr15:55652654G>T	uc002acv.1	-	8	1482	c.1317C>A	c.(1315-1317)ACC>ACA	p.T439T	CCPG1_uc002acy.2_Silent_p.T439T|CCPG1_uc002acu.1_Silent_p.T295T|CCPG1_uc002acw.1_Silent_p.T164T|CCPG1_uc002acx.2_Intron|CCPG1_uc010bfk.1_Silent_p.T439T|CCPG1_uc002acz.1_Silent_p.T439T	NM_020739	NP_065790	Q9ULG6	CCPG1_HUMAN	cell cycle progression 1 isoform 2	439	Potential.|Lumenal (Potential).				cell cycle	integral to membrane				ovary(1)	1				all cancers(107;0.0354)		GCTGTTCGAAGGTTAGCTTCC	0.413													7	142	---	---	---	---	PASS
FAM81A	145773	broad.mit.edu	37	15	59752205	59752205	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr15:59752205C>A	uc002agc.2	+	3	281	c.94C>A	c.(94-96)CAG>AAG	p.Q32K	FAM81A_uc010uha.1_Missense_Mutation_p.Q32K	NM_152450	NP_689663	Q8TBF8	FA81A_HUMAN	hypothetical protein LOC145773	32										ovary(1)	1						CCTCGTGGAGCAGCTGGAAGA	0.532													14	27	---	---	---	---	PASS
HCN4	10021	broad.mit.edu	37	15	73624553	73624553	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr15:73624553G>C	uc002avp.2	-	3	2284	c.1290C>G	c.(1288-1290)CAC>CAG	p.H430Q		NM_005477	NP_005468	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic	430	Helical; Name=Segment S5; (Potential).				blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			ovary(5)|liver(1)	6				COAD - Colon adenocarcinoma(1;0.142)		AGCCGTCCCAGTGGCAGAGCA	0.612													3	32	---	---	---	---	PASS
C15orf27	123591	broad.mit.edu	37	15	76449078	76449078	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr15:76449078A>G	uc002bbq.2	+	4	516	c.361A>G	c.(361-363)ATA>GTA	p.I121V	C15orf27_uc010bkp.2_Intron|C15orf27_uc002bbr.2_Intron	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	121	Helical; (Potential).					integral to membrane					0						GGAACTTCTAATAGATATAAA	0.433													9	34	---	---	---	---	PASS
TM6SF1	53346	broad.mit.edu	37	15	83795599	83795599	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr15:83795599G>C	uc002bjp.2	+	8	910	c.801G>C	c.(799-801)CAG>CAC	p.Q267H	TM6SF1_uc010bmq.2_Intron|TM6SF1_uc002bjq.2_Intron|TM6SF1_uc010bmr.2_Intron|TM6SF1_uc002bjr.2_Missense_Mutation_p.Q119H	NM_023003	NP_075379	Q9BZW5	TM6S1_HUMAN	transmembrane 6 superfamily member 1 isoform 1	267	Helical; (Potential).					integral to membrane				ovary(1)	1						CTAAAATTCAGGTCAAGTAGT	0.299													33	104	---	---	---	---	PASS
AGBL1	123624	broad.mit.edu	37	15	86800204	86800204	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr15:86800204G>T	uc002blz.1	+	7	798	c.718G>T	c.(718-720)GTC>TTC	p.V240F		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	240					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TGCCTTCCCGGTCCCCGGGTG	0.507													8	56	---	---	---	---	PASS
OR4F6	390648	broad.mit.edu	37	15	102346508	102346508	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr15:102346508G>C	uc010utr.1	+	1	586	c.586G>C	c.(586-588)GGA>CGA	p.G196R		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	196	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			CTACACATTGGGATTCATGGT	0.358													38	159	---	---	---	---	PASS
CCNF	899	broad.mit.edu	37	16	2505515	2505515	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:2505515G>T	uc002cqd.1	+	16	1923	c.1835G>T	c.(1834-1836)TGC>TTC	p.C612F	CCNF_uc002cqe.1_Missense_Mutation_p.C304F	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	612	PEST.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				CTGGACTGCTGCTCTGGCTAT	0.642													3	10	---	---	---	---	PASS
CREBBP	1387	broad.mit.edu	37	16	3900926	3900926	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:3900926C>A	uc002cvv.2	-	2	374	c.170G>T	c.(169-171)GGG>GTG	p.G57V	CREBBP_uc002cvw.2_Missense_Mutation_p.G57V	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	57					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AACAAGGTTCCCACTGTTTAA	0.428			T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				6	56	---	---	---	---	PASS
SRL	6345	broad.mit.edu	37	16	4247818	4247818	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:4247818G>C	uc002cvz.3	-	4	371	c.358C>G	c.(358-360)CGC>GGC	p.R120G	SRL_uc002cvy.3_RNA	NM_001098814	NP_001092284	Q86TD4	SRCA_HUMAN	sarcalumenin	579						sarcoplasmic reticulum lumen	GTP binding|GTPase activity			ovary(3)|skin(2)	5						AGCTGATAGCGAGTATTTTCC	0.383													30	16	---	---	---	---	PASS
CPPED1	55313	broad.mit.edu	37	16	12758807	12758807	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:12758807C>A	uc002dca.3	-	4	992	c.881G>T	c.(880-882)AGT>ATT	p.S294I	CPPED1_uc002dcb.3_Missense_Mutation_p.S152I|CPPED1_uc002dbz.3_RNA	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	294							hydrolase activity|metal ion binding				0						CTCATCTAGACTGTAGTATCG	0.507													12	51	---	---	---	---	PASS
MYH11	4629	broad.mit.edu	37	16	15814079	15814079	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:15814079C>T	uc002ddy.2	-	34	4989	c.4882G>A	c.(4882-4884)GAC>AAC	p.D1628N	MYH11_uc002ddv.2_Missense_Mutation_p.D1635N|MYH11_uc002ddw.2_Missense_Mutation_p.D1628N|MYH11_uc002ddx.2_Missense_Mutation_p.D1635N|MYH11_uc010bvg.2_Missense_Mutation_p.D1460N|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.D334N|NDE1_uc002ddz.1_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1628	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						AGCTCCAGGTCTTTCAGGTCC	0.587			T	CBFB	AML								6	48	---	---	---	---	PASS
XPO6	23214	broad.mit.edu	37	16	28109925	28109925	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:28109925C>A	uc002dpa.1	-	24	3813	c.3312G>T	c.(3310-3312)CTG>CTT	p.L1104L	XPO6_uc002dpb.1_Silent_p.L1090L|XPO6_uc010vcp.1_Silent_p.L1103L	NM_015171	NP_055986	Q96QU8	XPO6_HUMAN	exportin 6	1104					protein export from nucleus		protein binding|protein transporter activity			ovary(1)|skin(1)	2						GGTCGTTGACCAGCCTGTGCA	0.607													16	8	---	---	---	---	PASS
SULT1A1	6817	broad.mit.edu	37	16	28619685	28619685	+	Missense_Mutation	SNP	G	A	A	rs142537541		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:28619685G>A	uc002dqi.2	-	3	772	c.299C>T	c.(298-300)CCG>CTG	p.P100L	uc010vct.1_Intron|SULT1A1_uc002dqj.2_Missense_Mutation_p.P100L|SULT1A1_uc002dqk.2_Missense_Mutation_p.P100L|SULT1A1_uc002dql.2_Missense_Mutation_p.P100L|SULT1A1_uc002dqm.2_Intron|SULT1A1_uc002dqn.2_Missense_Mutation_p.P191L|SULT1A1_uc002dqo.2_Missense_Mutation_p.P100L|SULT1A1_uc002dqp.2_Missense_Mutation_p.P100L	NM_177534	NP_803878	P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A,	100					3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						TCGTGGGGCCGGTGTGTCTTT	0.537													21	73	---	---	---	---	PASS
SEZ6L2	26470	broad.mit.edu	37	16	29888689	29888689	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:29888689G>A	uc002duq.3	-	11	2052	c.1812C>T	c.(1810-1812)CGC>CGT	p.R604R	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Silent_p.R534R|SEZ6L2_uc002dur.3_Silent_p.R534R|SEZ6L2_uc002dus.3_Silent_p.R490R|SEZ6L2_uc010vec.1_Silent_p.R604R|SEZ6L2_uc010ved.1_Silent_p.R560R	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	604	CUB 3.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						AGGAGAGAAGGCGGCGGCGCG	0.662													6	0	---	---	---	---	PASS
SETD1A	9739	broad.mit.edu	37	16	30975589	30975589	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:30975589C>T	uc002ead.1	+	6	1500	c.814C>T	c.(814-816)CCC>TCC	p.P272S	SETD1A_uc002eae.1_Missense_Mutation_p.P272S	NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	272	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CCAAGGAACCCCCTACACGTC	0.632													10	35	---	---	---	---	PASS
CDH16	1014	broad.mit.edu	37	16	66950320	66950320	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:66950320G>A	uc002eql.2	-	4	215	c.142C>T	c.(142-144)CGT>TGT	p.R48C	CDH16_uc010cdy.2_Missense_Mutation_p.R48C|CDH16_uc002eqm.2_Missense_Mutation_p.R48C	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	48	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GCCCCCTCACGGGGCAGCGGC	0.552													7	18	---	---	---	---	PASS
HYDIN	54768	broad.mit.edu	37	16	71103239	71103239	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:71103239C>T	uc002ezr.2	-	14	2033	c.1905G>A	c.(1903-1905)ATG>ATA	p.M635I	HYDIN_uc010cfz.1_Missense_Mutation_p.M380I|HYDIN_uc002ezv.2_Missense_Mutation_p.M635I|HYDIN_uc010vmc.1_Missense_Mutation_p.M652I|HYDIN_uc010vmd.1_Missense_Mutation_p.M662I|HYDIN_uc002ezw.3_Missense_Mutation_p.M652I	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	635										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CTTTTGGTTTCATTGAGGATA	0.483													8	54	---	---	---	---	PASS
PMFBP1	83449	broad.mit.edu	37	16	72159293	72159293	+	Silent	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:72159293C>G	uc002fcc.3	-	16	2452	c.2280G>C	c.(2278-2280)GTG>GTC	p.V760V	PMFBP1_uc002fcd.2_Silent_p.V755V|PMFBP1_uc002fce.2_RNA|PMFBP1_uc002fcf.2_Silent_p.V610V|PMFBP1_uc010cgo.1_Silent_p.V51V	NM_031293	NP_112583	Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	760										ovary(2)	2		Ovarian(137;0.179)				TCTCTGAGGTCACGTGATTGA	0.488											OREG0023927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	93	---	---	---	---	PASS
RFWD3	55159	broad.mit.edu	37	16	74666541	74666541	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:74666541T>C	uc002fda.2	-	9	1555	c.1457A>G	c.(1456-1458)AAC>AGC	p.N486S	RFWD3_uc010vmx.1_Missense_Mutation_p.N6S|RFWD3_uc010cgq.2_Missense_Mutation_p.N486S	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	486					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						GCTCTTCATGTTGGCAGTACT	0.433													6	28	---	---	---	---	PASS
VAT1L	57687	broad.mit.edu	37	16	77850871	77850871	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:77850871C>T	uc002ffg.1	+	2	384	c.287C>T	c.(286-288)CCC>CTC	p.P96L		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	96							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						GACAACCCTCCCAAGACTCCC	0.438													11	56	---	---	---	---	PASS
LRRC50	123872	broad.mit.edu	37	16	84188191	84188191	+	Missense_Mutation	SNP	G	A	A	rs34897947		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:84188191G>A	uc002fhl.3	+	4	543	c.362G>A	c.(361-363)CGC>CAC	p.R121H	LRRC50_uc010chi.1_RNA	NM_178452	NP_848547	Q8NEP3	DAAF1_HUMAN	leucine rich repeat containing 50	121	LRR 1.				axonemal dynein complex assembly|cilium morphogenesis	cilium axoneme|cytoplasm|spindle pole	dynein binding				0						GGTTTTGATCGCATTGAGAAC	0.478									Kartagener_syndrome				5	30	---	---	---	---	PASS
FOXF1	2294	broad.mit.edu	37	16	86544553	86544553	+	Silent	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:86544553G>C	uc002fjl.2	+	1	421	c.378G>C	c.(376-378)CCG>CCC	p.P126P	uc002fjk.1_5'Flank	NM_001451	NP_001442	Q12946	FOXF1_HUMAN	forkhead box F1	126	Fork-head.				branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0						CCATCGACCCGGCCAGCGAGT	0.632													28	21	---	---	---	---	PASS
ZNF778	197320	broad.mit.edu	37	16	89294627	89294627	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:89294627C>A	uc002fmv.2	+	6	2186	c.1847C>A	c.(1846-1848)CCC>CAC	p.P616H	ZNF778_uc010vpf.1_Intron|ZNF778_uc002fmw.1_Missense_Mutation_p.P574H|ZNF778_uc010vpg.1_Missense_Mutation_p.P379H	NM_182531	NP_872337	Q96MU6	ZN778_HUMAN	zinc finger protein 778	616					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(80;0.0269)		GGTGAGAAACCCTACATATGT	0.463													19	70	---	---	---	---	PASS
RAP1GAP2	23108	broad.mit.edu	37	17	2866729	2866729	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:2866729C>A	uc010ckd.2	+	6	342	c.252C>A	c.(250-252)GAC>GAA	p.D84E	RAP1GAP2_uc010cke.2_Missense_Mutation_p.D69E	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	84					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						TGCAGGACGACTATATCCCAT	0.587													25	69	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7577046	7577046	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:7577046C>A	uc002gim.2	-	8	1086	c.892G>T	c.(892-894)GAG>TAG	p.E298*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.E298*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E166*|TP53_uc010cng.1_Nonsense_Mutation_p.E166*|TP53_uc002gii.1_Nonsense_Mutation_p.E166*|TP53_uc010cnh.1_Nonsense_Mutation_p.E298*|TP53_uc010cni.1_Nonsense_Mutation_p.E298*|TP53_uc002gij.2_Nonsense_Mutation_p.E298*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	298	Interaction with HIPK1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E298*(35)|p.0?(7)|p.E298K(2)|p.?(2)|p.E298V(2)|p.L299fs*2(1)|p.L265_K305del41(1)|p.E298A(1)|p.E298fs*53(1)|p.G293fs*1(1)|p.E298fs*47(1)|p.E298E(1)|p.E298Q(1)|p.E298_P301delELPP(1)|p.H296_S303delHHELPPGS(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGGCAGCTCGTGGTGAGGC	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			20	12	---	---	---	---	PASS
CNTROB	116840	broad.mit.edu	37	17	7840130	7840130	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:7840130C>A	uc002gjq.2	+	7	1742	c.823C>A	c.(823-825)CAG>AAG	p.Q275K	CNTROB_uc002gjp.2_Missense_Mutation_p.Q275K|CNTROB_uc002gjr.2_Missense_Mutation_p.Q177K|CNTROB_uc010vum.1_5'Flank	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	275	Potential.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				AAGCAAGCAGCAGGAGGTGAG	0.547													21	10	---	---	---	---	PASS
MYH2	4620	broad.mit.edu	37	17	10426947	10426947	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:10426947C>A	uc010coi.2	-	37	5466	c.5338G>T	c.(5338-5340)GAC>TAC	p.D1780Y	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.D1780Y|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1780	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GCGCTGGTGTCCTGCTCCTTC	0.507													34	25	---	---	---	---	PASS
FAM83G	644815	broad.mit.edu	37	17	18891670	18891670	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:18891670C>G	uc002guw.2	-	3	747	c.580G>C	c.(580-582)GAC>CAC	p.D194H	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	194										ovary(1)|central_nervous_system(1)	2						AAGCCGGCGTCCAGCAGGTCC	0.557													7	84	---	---	---	---	PASS
ATAD5	79915	broad.mit.edu	37	17	29162409	29162409	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:29162409T>A	uc002hfs.1	+	2	1656	c.1310T>A	c.(1309-1311)GTA>GAA	p.V437E	ATAD5_uc002hft.1_Missense_Mutation_p.V334E	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	437					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				CTATATGAAGTAGGAAGAGAT	0.313													30	44	---	---	---	---	PASS
MYO1D	4642	broad.mit.edu	37	17	31098203	31098203	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:31098203A>G	uc002hho.1	-	6	666	c.654T>C	c.(652-654)TCT>TCC	p.S218S	MYO1D_uc002hhp.1_Silent_p.S218S|MYO1D_uc010wcb.1_Silent_p.S218S	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	218	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			GGAGATGTAGAGAGCGTAGCA	0.363													5	37	---	---	---	---	PASS
NLE1	54475	broad.mit.edu	37	17	33463218	33463218	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:33463218C>T	uc002hiy.1	-	9	1009	c.981G>A	c.(979-981)GAG>GAA	p.E327E	NLE1_uc010ctn.1_Silent_p.E35E|NLE1_uc002hiz.1_Silent_p.E35E	NM_018096	NP_060566	Q9NVX2	NLE1_HUMAN	Notchless gene homolog isoform a	327	WD 5.					nucleolus				breast(3)|ovary(1)	4		Ovarian(249;0.17)				TCAGAGCCCTCTCCTTCAACT	0.537													10	177	---	---	---	---	PASS
PEX12	5193	broad.mit.edu	37	17	33904432	33904432	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:33904432C>A	uc002hjp.2	-	2	921	c.305G>T	c.(304-306)AGA>ATA	p.R102I		NM_000286	NP_000277	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	102	Cytoplasmic (Potential).				protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACTAGCCAATCTCTGAGACTT	0.438													74	106	---	---	---	---	PASS
KRTAP9-2	83899	broad.mit.edu	37	17	39382974	39382974	+	Missense_Mutation	SNP	G	T	T	rs149082553	byFrequency	TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:39382974G>T	uc002hwf.2	+	1	75	c.68G>T	c.(67-69)TGC>TTC	p.C23F		NM_031961	NP_114167	Q9BYQ4	KRA92_HUMAN	keratin associated protein 9.2	23	17 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]- [TASP].					keratin filament	protein binding	p.C23*(1)		upper_aerodigestive_tract(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			AGGACCACCTGCTGGAAGCCC	0.647													5	79	---	---	---	---	PASS
KRTAP9-4	85280	broad.mit.edu	37	17	39406040	39406040	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:39406040G>T	uc002hwi.2	+	1	102	c.68G>T	c.(67-69)TGC>TTC	p.C23F	KRTAP9-9_uc010wfq.1_Intron	NM_033191	NP_149461	Q9BYQ2	KRA94_HUMAN	keratin associated protein 9-4	23	15 X 5 AA repeats of C-C-[RQVGE]-[SPTN]- [TASPF].					keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			AGGACCACCTGCTGGAAGCCC	0.627													27	63	---	---	---	---	PASS
KRT32	3882	broad.mit.edu	37	17	39623327	39623327	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:39623327C>T	uc002hwr.2	-	1	312	c.251G>A	c.(250-252)GGC>GAC	p.G84D		NM_002278	NP_002269	Q14532	K1H2_HUMAN	keratin 32	84	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000812)				GTACCAGCTGCCGGGGCCCAT	0.622													6	38	---	---	---	---	PASS
FKBP10	60681	broad.mit.edu	37	17	39974690	39974690	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:39974690G>A	uc002hxv.2	+	4	963	c.638G>A	c.(637-639)GGC>GAC	p.G213D	FKBP10_uc002hxw.1_5'Flank	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	213	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		CTGATCAAGGGCATGGACCAG	0.587													18	24	---	---	---	---	PASS
GPATCH8	23131	broad.mit.edu	37	17	42478425	42478425	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:42478425G>A	uc002igw.1	-	8	1084	c.1020C>T	c.(1018-1020)GAC>GAT	p.D340D	GPATCH8_uc002igv.1_Silent_p.D262D|GPATCH8_uc010wiz.1_Silent_p.D262D	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	340						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GCAGTCCTTGGTCAGAACTCT	0.483											OREG0024461	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	54	56	---	---	---	---	PASS
CDC27	996	broad.mit.edu	37	17	45219266	45219266	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:45219266G>A	uc002ild.3	-	12	1631	c.1504C>T	c.(1504-1506)CTG>TTG	p.L502L	CDC27_uc002ile.3_Silent_p.L508L|CDC27_uc002ilf.3_Silent_p.L501L|CDC27_uc010wkp.1_Silent_p.L441L|CDC27_uc010wkq.1_Intron	NM_001256	NP_001247	P30260	CDC27_HUMAN	cell division cycle protein 27 isoform 2	502	TPR 3.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			lung(2)|breast(2)|ovary(1)	5						ATTTGGCACAGTACCCAACCA	0.348													8	172	---	---	---	---	PASS
PDK2	5164	broad.mit.edu	37	17	48185764	48185764	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:48185764G>T	uc002iqc.2	+	8	948	c.844G>T	c.(844-846)GAA>TAA	p.E282*	PDK2_uc002iqb.2_Nonsense_Mutation_p.E218*	NM_002611	NP_002602	Q15119	PDK2_HUMAN	pyruvate dehydrogenase kinase 2 precursor	282	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|nucleus	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(3)	3						CTTGGGTGAGGAAGATCTGTC	0.577									Autosomal_Dominant_Polycystic_Kidney_Disease				7	19	---	---	---	---	PASS
OR4D2	124538	broad.mit.edu	37	17	56247070	56247070	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:56247070G>A	uc010wnp.1	+	1	54	c.54G>A	c.(52-54)TCG>TCA	p.S18S		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TGGGGCTCTCGCAGACTCGGG	0.468													42	56	---	---	---	---	PASS
EPX	8288	broad.mit.edu	37	17	56270463	56270463	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:56270463G>A	uc002ivq.2	+	2	227	c.141G>A	c.(139-141)GTG>GTA	p.V47V		NM_000502	NP_000493	P11678	PERE_HUMAN	eosinophil peroxidase preproprotein	47					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			ovary(2)	2						AGTTGCTGGTGGATGCTGCCT	0.607													24	49	---	---	---	---	PASS
MTMR4	9110	broad.mit.edu	37	17	56573053	56573053	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:56573053G>A	uc002iwj.2	-	16	2560	c.2450C>T	c.(2449-2451)CCA>CTA	p.P817L		NM_004687	NP_004678	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	817						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			skin(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGCACTCGGTGGGTTGCAAAC	0.562													13	61	---	---	---	---	PASS
CLTC	1213	broad.mit.edu	37	17	57743957	57743957	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:57743957A>G	uc002ixq.1	+	12	2342	c.1899A>G	c.(1897-1899)TTA>TTG	p.L633L	CLTC_uc002ixp.2_Silent_p.L633L|CLTC_uc002ixr.1_Silent_p.L637L	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	633	Heavy chain arm.|Distal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TCACTGATTTATATGATATAA	0.398			T	ALK|TFE3	ALCL|renal 								20	26	---	---	---	---	PASS
RNFT1	51136	broad.mit.edu	37	17	58040613	58040613	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:58040613G>A	uc002iya.2	-	2	182	c.89C>T	c.(88-90)TCA>TTA	p.S30L	uc002iye.1_5'Flank|RNFT1_uc002iyb.2_RNA|RNFT1_uc002iyc.2_5'UTR|RNFT1_uc010wop.1_Missense_Mutation_p.S30L|RNFT1_uc002iyd.3_Missense_Mutation_p.S30L	NM_016125	NP_057209	Q5M7Z0	RNFT1_HUMAN	PTD016 protein	30						integral to membrane	zinc ion binding				0	all_cancers(5;1.58e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;7.95e-12)|all cancers(12;1.34e-10)			CTTTTTCTCTGACCCAGATGT	0.443													17	73	---	---	---	---	PASS
ABCA6	23460	broad.mit.edu	37	17	67077276	67077276	+	Missense_Mutation	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:67077276A>T	uc002jhw.1	-	37	4802	c.4627T>A	c.(4627-4629)TTG>ATG	p.L1543M		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1543					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					TAGGTTAACAAAGAGGAATAC	0.373													13	57	---	---	---	---	PASS
RHBDF2	79651	broad.mit.edu	37	17	74473789	74473789	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:74473789C>A	uc002jrq.1	-	7	1131	c.838G>T	c.(838-840)GAG>TAG	p.E280*	RHBDF2_uc002jrp.1_Nonsense_Mutation_p.E251*|RHBDF2_uc002jrr.1_Nonsense_Mutation_p.E132*|RHBDF2_uc010wtf.1_Nonsense_Mutation_p.E251*|RHBDF2_uc002jrs.1_Nonsense_Mutation_p.E275*	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	280	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						ACCACATCCTCCTCCAGGAAG	0.637													6	91	---	---	---	---	PASS
ENGASE	64772	broad.mit.edu	37	17	77082341	77082341	+	Silent	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:77082341A>G	uc002jwv.2	+	14	2150	c.2142A>G	c.(2140-2142)GAA>GAG	p.E714E	ENGASE_uc002jww.2_Silent_p.E419E	NM_001042573	NP_001036038	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	714						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			skin(1)	1						GTCGCATGGAATTTCTGGTGG	0.617													8	20	---	---	---	---	PASS
ZNF750	79755	broad.mit.edu	37	17	80790192	80790192	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:80790192C>A	uc002kga.2	-	2	450	c.139G>T	c.(139-141)GGT>TGT	p.G47C	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	47						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TTACAAAGACCATACTTCATG	0.423													5	94	---	---	---	---	PASS
COLEC12	81035	broad.mit.edu	37	18	346412	346412	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:346412C>G	uc002kkm.2	-	5	1425	c.1210G>C	c.(1210-1212)GAT>CAT	p.D404H		NM_130386	NP_569057	Q5KU26	COL12_HUMAN	collectin sub-family member 12	404	Extracellular (Potential).				carbohydrate mediated signaling|innate immune response|phagocytosis, recognition|protein homooligomerization	collagen|integral to membrane	galactose binding|low-density lipoprotein particle binding|metal ion binding|pattern recognition receptor activity|scavenger receptor activity			ovary(1)|pancreas(1)	2		all_cancers(4;0.0442)|Myeloproliferative disorder(11;0.0426)				CTCATCAAATCTTGTTGCATC	0.428													14	75	---	---	---	---	PASS
MYOM1	8736	broad.mit.edu	37	18	3189056	3189056	+	Missense_Mutation	SNP	G	A	A	rs140845661	by1000genomes	TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:3189056G>A	uc002klp.2	-	4	795	c.461C>T	c.(460-462)ACG>ATG	p.T154M	MYOM1_uc002klq.2_Missense_Mutation_p.T154M	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	154						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TTCTTCTTCCGTATCAGTAAT	0.383													12	109	---	---	---	---	PASS
APCDD1	147495	broad.mit.edu	37	18	10485545	10485545	+	Silent	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:10485545G>C	uc002kom.3	+	4	1215	c.861G>C	c.(859-861)CTG>CTC	p.L287L		NM_153000	NP_694545	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	287	Extracellular (Potential).				hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding				0				READ - Rectum adenocarcinoma(15;0.08)		AGGCAGACCTGACCATCGGCC	0.597													7	46	---	---	---	---	PASS
DSC3	1825	broad.mit.edu	37	18	28612167	28612167	+	Missense_Mutation	SNP	T	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:28612167T>G	uc002kwj.3	-	2	300	c.145A>C	c.(145-147)ATT>CTT	p.I49L	DSC3_uc002kwi.3_Missense_Mutation_p.I49L	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	49					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CCTCTGCCAATTATTTTGTCT	0.343													8	26	---	---	---	---	PASS
KIAA1012	22878	broad.mit.edu	37	18	29487430	29487430	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:29487430C>G	uc002kxc.3	-	9	1746	c.1382G>C	c.(1381-1383)GGT>GCT	p.G461A	KIAA1012_uc002kxb.3_Missense_Mutation_p.G407A|KIAA1012_uc002kxd.3_RNA|KIAA1012_uc002kxe.2_Missense_Mutation_p.G461A	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	461					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						AACCAAGGCACCAGCTGCATA	0.338													6	75	---	---	---	---	PASS
ASXL3	80816	broad.mit.edu	37	18	31324142	31324142	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:31324142C>A	uc010dmg.1	+	12	4385	c.4330C>A	c.(4330-4332)CGA>AGA	p.R1444R	ASXL3_uc002kxq.2_Silent_p.R1151R	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1444					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						TTCAGGGCCTCGAAACAGGGC	0.468											OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	190	---	---	---	---	PASS
NOL4	8715	broad.mit.edu	37	18	31432874	31432874	+	Silent	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:31432874G>T	uc010dmi.2	-	11	2078	c.1849C>A	c.(1849-1851)CGA>AGA	p.R617R	NOL4_uc010xbs.1_Silent_p.R332R|NOL4_uc002kxr.3_Silent_p.R389R|NOL4_uc010xbt.1_Silent_p.R543R|NOL4_uc010dmh.2_Silent_p.R479R|NOL4_uc010xbu.1_Silent_p.R553R|NOL4_uc002kxt.3_Silent_p.R515R	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	617						nucleolus	RNA binding			ovary(3)	3						GCTGATTCTCGATATCCTGCA	0.458													18	41	---	---	---	---	PASS
DTNA	1837	broad.mit.edu	37	18	32455336	32455336	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:32455336G>A	uc010dmn.1	+	17	1797	c.1796G>A	c.(1795-1797)GGA>GAA	p.G599E	DTNA_uc002kxw.2_Missense_Mutation_p.G542E|DTNA_uc010dmj.2_Missense_Mutation_p.G539E|DTNA_uc002kxz.2_Missense_Mutation_p.G546E|DTNA_uc002kxy.2_Missense_Mutation_p.G539E|DTNA_uc010xby.1_Missense_Mutation_p.G289E|DTNA_uc010xbz.1_Missense_Mutation_p.G308E|DTNA_uc010xca.1_Missense_Mutation_p.G251E|DTNA_uc002kye.2_Missense_Mutation_p.G247E	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	599					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						GGAGTAGGGGGAGATGTACAA	0.527													22	10	---	---	---	---	PASS
POLI	11201	broad.mit.edu	37	18	51820157	51820157	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:51820157A>G	uc002lfj.3	+	10	1611	c.1543A>G	c.(1543-1545)ATT>GTT	p.I515V	POLI_uc010xds.1_Missense_Mutation_p.I436V|POLI_uc002lfk.3_Missense_Mutation_p.I412V|POLI_uc010dpg.2_Missense_Mutation_p.I111V	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	515					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		AGAAAAAGACATTAATGAATT	0.378								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					10	18	---	---	---	---	PASS
TCF4	6925	broad.mit.edu	37	18	52924583	52924583	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:52924583G>A	uc002lfz.2	-	14	1721	c.1109C>T	c.(1108-1110)TCA>TTA	p.S370L	TCF4_uc002lfw.3_Missense_Mutation_p.S210L|TCF4_uc010xdu.1_Missense_Mutation_p.S240L|TCF4_uc010xdv.1_Missense_Mutation_p.S240L|TCF4_uc002lfx.2_Missense_Mutation_p.S299L|TCF4_uc010xdw.1_Missense_Mutation_p.S240L|TCF4_uc002lfy.2_Missense_Mutation_p.S328L|TCF4_uc010xdx.1_Missense_Mutation_p.S346L|TCF4_uc010dph.1_Missense_Mutation_p.S370L|TCF4_uc010xdy.1_Missense_Mutation_p.S346L|TCF4_uc002lga.2_Missense_Mutation_p.S472L|TCF4_uc002lgb.1_Missense_Mutation_p.S210L|TCF4_uc010dpi.2_Missense_Mutation_p.S376L|TCF4_uc002lfv.2_Missense_Mutation_p.S153L	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	370					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		AGGAGACGATGAGGCCTGTCC	0.418													36	51	---	---	---	---	PASS
KIAA1468	57614	broad.mit.edu	37	18	59972682	59972682	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:59972682A>C	uc002lil.2	+	29	3781	c.3566A>C	c.(3565-3567)GAT>GCT	p.D1189A	KIAA1468_uc010xel.1_Missense_Mutation_p.D1189A|KIAA1468_uc002lim.2_Missense_Mutation_p.D867A	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	1189							binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				GTGAGTGAAGATACAAAGACC	0.323													20	98	---	---	---	---	PASS
ZNF407	55628	broad.mit.edu	37	18	72632562	72632562	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:72632562G>T	uc002llw.2	+	7	5399	c.5342G>T	c.(5341-5343)GGG>GTG	p.G1781V	ZNF407_uc010dqu.1_Missense_Mutation_p.G1781V	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1781	C2H2-type 22.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TGTGACTACGGGACCAACGTC	0.493													4	35	---	---	---	---	PASS
SALL3	27164	broad.mit.edu	37	18	76756945	76756945	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:76756945C>A	uc002lmt.2	+	3	3526	c.3526C>A	c.(3526-3528)CTG>ATG	p.L1176M	SALL3_uc010dra.2_Missense_Mutation_p.L711M	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1176					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CGGCCGCCGCCTGTCTGTGGA	0.617													6	15	---	---	---	---	PASS
SALL3	27164	broad.mit.edu	37	18	76757113	76757113	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr18:76757113G>A	uc002lmt.2	+	3	3694	c.3694G>A	c.(3694-3696)GTC>ATC	p.V1232I	SALL3_uc010dra.2_Missense_Mutation_p.V767I	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	1232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CGAGATCTCCGTCATCCAGAA	0.622													6	71	---	---	---	---	PASS
REXO1	57455	broad.mit.edu	37	19	1828009	1828009	+	Missense_Mutation	SNP	C	A	A	rs143118600		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:1828009C>A	uc002lua.3	-	2	874	c.779G>T	c.(778-780)CGG>CTG	p.R260L	REXO1_uc010dsr.1_Missense_Mutation_p.R214L	NM_020695	NP_065746	Q8N1G1	REXO1_HUMAN	transcription elongation factor B polypeptide 3	260						nucleus	exonuclease activity|nucleic acid binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGGAGCCCCGGGGCCGCTT	0.652													4	9	---	---	---	---	PASS
INSR	3643	broad.mit.edu	37	19	7125485	7125485	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:7125485T>C	uc002mgd.1	-	17	3176	c.3067A>G	c.(3067-3069)ATC>GTC	p.I1023V	INSR_uc002mge.1_Missense_Mutation_p.I1011V	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1023	Protein kinase.|Cytoplasmic (Potential).		I -> F.		activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AGGAGGGTGATCTTCTCTCGA	0.577													13	32	---	---	---	---	PASS
KIAA1543	57662	broad.mit.edu	37	19	7675433	7675433	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:7675433G>A	uc002mgv.3	+	6	933	c.832G>A	c.(832-834)GCC>ACC	p.A278T	KIAA1543_uc002mgu.3_Missense_Mutation_p.A305T	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	278	CH.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						GGATTTCTGTGCCTCTCGCCT	0.632													16	54	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9065831	9065831	+	Silent	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:9065831T>A	uc002mkp.2	-	3	21819	c.21615A>T	c.(21613-21615)ACA>ACT	p.T7205T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7207	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGCTTTGGATGTCTCTGAGT	0.488													22	78	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9071159	9071159	+	Silent	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:9071159A>T	uc002mkp.2	-	3	16491	c.16287T>A	c.(16285-16287)ACT>ACA	p.T5429T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5431	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGACCCGGAAGTCCCTACAT	0.527													50	173	---	---	---	---	PASS
OR7G3	390883	broad.mit.edu	37	19	9237355	9237355	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:9237355G>T	uc010xkl.1	-	1	272	c.272C>A	c.(271-273)TCC>TAC	p.S91Y		NM_001001958	NP_001001958	Q8NG95	OR7G3_HUMAN	olfactory receptor, family 7, subfamily G,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GTAATTGATGGATTGAGCCTG	0.483													30	53	---	---	---	---	PASS
DNMT1	1786	broad.mit.edu	37	19	10251824	10251824	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:10251824G>T	uc002mng.2	-	30	3483	c.3303C>A	c.(3301-3303)AAC>AAA	p.N1101K	DNMT1_uc002mne.2_5'Flank|DNMT1_uc002mnf.2_Missense_Mutation_p.N25K|DNMT1_uc010xlc.1_Missense_Mutation_p.N1117K|DNMT1_uc002mnh.2_Missense_Mutation_p.N996K|DNMT1_uc010xld.1_Missense_Mutation_p.N1101K	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1101					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	TACGGGCATGGTTGGGAGGAT	0.468													11	69	---	---	---	---	PASS
TYK2	7297	broad.mit.edu	37	19	10477140	10477140	+	Silent	SNP	G	T	T	rs147934502		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:10477140G>T	uc002moc.3	-	6	960	c.582C>A	c.(580-582)CTC>CTA	p.L194L	TYK2_uc010dxe.2_Silent_p.L9L|TYK2_uc002mod.2_Silent_p.L194L	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	194	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			GGCGGAGAGCGAGGTGACAGA	0.597													4	70	---	---	---	---	PASS
AKAP8	10270	broad.mit.edu	37	19	15484801	15484801	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:15484801G>C	uc002nav.2	-	4	228	c.167C>G	c.(166-168)GCC>GGC	p.A56G	AKAP8_uc010dzy.2_5'Flank|AKAP8_uc010dzz.1_RNA|AKAP8_uc010xog.1_Intron	NM_005858	NP_005849	O43823	AKAP8_HUMAN	A-kinase anchor protein 8	56					signal transduction	nuclear matrix				ovary(1)|breast(1)	2						CTCCCACGAGGCTGGGCCGTA	0.622													8	69	---	---	---	---	PASS
IL12RB1	3594	broad.mit.edu	37	19	18186641	18186641	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:18186641C>A	uc002nhw.1	-	7	682	c.618G>T	c.(616-618)CAG>CAT	p.Q206H	IL12RB1_uc010xqb.1_Missense_Mutation_p.Q206H|IL12RB1_uc002nhx.1_Missense_Mutation_p.Q246H|IL12RB1_uc002nhy.2_Missense_Mutation_p.Q206H	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	206	Extracellular (Potential).|Fibronectin type-III 2.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						GCTGGAATTCCTGGGCCACAT	0.572													4	38	---	---	---	---	PASS
GDF1	2657	broad.mit.edu	37	19	18995020	18995020	+	Nonsense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:18995020C>A	uc002nki.1	-	3	538	c.466G>T	c.(466-468)GGA>TGA	p.G156*	LASS1_uc002nkj.2_Nonsense_Mutation_p.G156*|LASS1_uc010ebx.2_Nonsense_Mutation_p.G58*	NM_021267	NP_067090	P27539	GDF1_HUMAN	LAG1 homolog, ceramide synthase 1 isoform 1	Error:Variant_position_missing_in_P27539_after_alignment					growth	extracellular space	cytokine activity|growth factor activity				0						TAGAAGCTTCCCTGGAGCAGG	0.607													4	17	---	---	---	---	PASS
NCAN	1463	broad.mit.edu	37	19	19338799	19338799	+	Silent	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:19338799G>C	uc002nlz.2	+	8	2469	c.2370G>C	c.(2368-2370)CTG>CTC	p.L790L	NCAN_uc010ecc.1_Silent_p.L354L	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	790					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GCAAAGGGCTGGATGCAAGTT	0.577													46	23	---	---	---	---	PASS
NCAN	1463	broad.mit.edu	37	19	19338800	19338800	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:19338800G>T	uc002nlz.2	+	8	2470	c.2371G>T	c.(2371-2373)GAT>TAT	p.D791Y	NCAN_uc010ecc.1_Missense_Mutation_p.D355Y	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	791					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CAAAGGGCTGGATGCAAGTTC	0.582													44	23	---	---	---	---	PASS
ZNF253	56242	broad.mit.edu	37	19	20003536	20003536	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:20003536C>A	uc002noj.2	+	4	1572	c.1480C>A	c.(1480-1482)CTT>ATT	p.L494I	ZNF253_uc002nok.2_Missense_Mutation_p.L418I|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	494					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTTCCTCCACTTTTAATTAG	0.343													9	69	---	---	---	---	PASS
ZNF43	7594	broad.mit.edu	37	19	21990988	21990988	+	Silent	SNP	A	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:21990988A>T	uc002nqj.2	-	4	1981	c.1851T>A	c.(1849-1851)ACT>ACA	p.T617T	ZNF43_uc010ecv.2_Silent_p.T611T|ZNF43_uc002nql.2_Silent_p.T611T|ZNF43_uc002nqm.2_Silent_p.T611T|ZNF43_uc002nqk.2_Silent_p.T547T	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	617					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		GTTTTCCTCCAGTATGAATTT	0.338													5	78	---	---	---	---	PASS
ZNF208	7757	broad.mit.edu	37	19	22154213	22154213	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:22154213C>T	uc002nqp.2	-	6	3388	c.3239G>A	c.(3238-3240)TGG>TAG	p.W1080*	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGTTGAGGGCCACTTATAGGC	0.393													82	60	---	---	---	---	PASS
ZNF676	163223	broad.mit.edu	37	19	22362957	22362957	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:22362957G>T	uc002nqs.1	-	3	1880	c.1562C>A	c.(1561-1563)ACT>AAT	p.T521N		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	521	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CTTATGTTCAGTAAGGATCGA	0.398													8	184	---	---	---	---	PASS
ZNF91	7644	broad.mit.edu	37	19	23542365	23542365	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:23542365C>G	uc002nre.2	-	4	3529	c.3416G>C	c.(3415-3417)TGT>TCT	p.C1139S	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.C1107S	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	1139	C2H2-type 36.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGCTTTGCCACATTTTTCACA	0.279													15	29	---	---	---	---	PASS
ZNF536	9745	broad.mit.edu	37	19	30935497	30935497	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:30935497A>G	uc002nsu.1	+	2	1166	c.1028A>G	c.(1027-1029)AAC>AGC	p.N343S	ZNF536_uc010edd.1_Missense_Mutation_p.N343S	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CAGTCGGCCAACGAGTTCCGC	0.647													11	101	---	---	---	---	PASS
ZNF536	9745	broad.mit.edu	37	19	30935825	30935825	+	Silent	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:30935825C>G	uc002nsu.1	+	2	1494	c.1356C>G	c.(1354-1356)CTC>CTG	p.L452L	ZNF536_uc010edd.1_Silent_p.L452L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCAGCCAGCTCTATGGCAAGG	0.657													5	21	---	---	---	---	PASS
ZNF536	9745	broad.mit.edu	37	19	31039661	31039661	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:31039661C>T	uc002nsu.1	+	4	3273	c.3135C>T	c.(3133-3135)GCC>GCT	p.A1045A	ZNF536_uc010edd.1_Silent_p.A1045A	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1045					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					AAGACCAAGCCCGGGAGGCGA	0.537													15	44	---	---	---	---	PASS
FXYD1	5348	broad.mit.edu	37	19	35630999	35630999	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:35630999C>A	uc002nyc.2	+	2	87	c.16C>A	c.(16-18)CAC>AAC	p.H6N	LGI4_uc002nxy.1_Intron|FXYD1_uc002nyb.1_RNA|FXYD1_uc002nyd.2_Missense_Mutation_p.H6N	NM_021902	NP_068702	O00168	PLM_HUMAN	phospholemman precursor	6					muscle contraction	chloride channel complex|integral to plasma membrane	chloride channel activity				0	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;2.32e-21)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;2.43e-18)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GTCTCTTGGCCACATCTTGGT	0.612													24	26	---	---	---	---	PASS
MLL4	9757	broad.mit.edu	37	19	36218350	36218350	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:36218350G>T	uc010eei.2	+	17	4129	c.4129G>T	c.(4129-4131)GAG>TAG	p.E1377*		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1377	PHD-type 3.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGAAGACTACGAGATCCTTTC	0.622													6	211	---	---	---	---	PASS
TYROBP	7305	broad.mit.edu	37	19	36398473	36398473	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:36398473C>A	uc002ocm.2	-	3	160	c.104G>T	c.(103-105)TGC>TTC	p.C35F	TYROBP_uc002ocn.2_Missense_Mutation_p.C35F	NM_003332	NP_003323	O43914	TYOBP_HUMAN	TYRO protein tyrosine kinase binding protein	35	Extracellular (Potential).				axon guidance|cell junction assembly|cellular defense response|intracellular signal transduction|regulation of immune response	integral to plasma membrane|intracellular	identical protein binding|receptor signaling protein activity				0	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CACCGTAGAGCAACTGCAATC	0.642													10	23	---	---	---	---	PASS
ZNF461	92283	broad.mit.edu	37	19	37130589	37130589	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:37130589C>G	uc002oem.2	-	6	886	c.658G>C	c.(658-660)GAA>CAA	p.E220Q	ZNF461_uc002oen.2_Missense_Mutation_p.E189Q|ZNF461_uc010xtj.1_Missense_Mutation_p.E197Q	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TCTTTACATTCAGAAAGTTCT	0.299													29	42	---	---	---	---	PASS
ZNF461	92283	broad.mit.edu	37	19	37149309	37149309	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:37149309C>A	uc002oem.2	-	3	256	c.28G>T	c.(28-30)GAT>TAT	p.D10Y	ZNF461_uc002oen.2_5'UTR|ZNF461_uc010xtj.1_Missense_Mutation_p.D10Y	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	gonadotropin inducible transcription repressor	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			ATAGCCACATCTCTGAACATC	0.363													6	35	---	---	---	---	PASS
ZNF585A	199704	broad.mit.edu	37	19	37643905	37643905	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:37643905T>A	uc002ofo.1	-	5	1127	c.896A>T	c.(895-897)GAG>GTG	p.E299V	ZNF585A_uc002ofm.1_Missense_Mutation_p.E244V|ZNF585A_uc002ofn.1_Missense_Mutation_p.E244V	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	299	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GTTACTGCACTCATATGGTTT	0.438													120	99	---	---	---	---	PASS
ZNF613	79898	broad.mit.edu	37	19	52443504	52443504	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:52443504G>T	uc002pxz.1	+	4	481	c.58G>T	c.(58-60)GAG>TAG	p.E20*	ZNF613_uc002pya.1_5'UTR	NM_001031721	NP_001026891	Q6PF04	ZN613_HUMAN	zinc finger protein 613 isoform 1	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		GTTCACTTGGGAGGAGTGGCA	0.498													6	116	---	---	---	---	PASS
ZNF813	126017	broad.mit.edu	37	19	53989949	53989949	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:53989949C>T	uc002qbu.2	+	3	207	c.79C>T	c.(79-81)CCT>TCT	p.P27S	ZNF813_uc010eqq.1_RNA	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	27	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		ATGCCTGGACCCTGCTCAGAG	0.483													13	190	---	---	---	---	PASS
MIR519B	574469	broad.mit.edu	37	19	54198504	54198504	+	RNA	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:54198504T>C	hsa-mir-519b|MI0003151	+			c.38T>C			MIR525_hsa-mir-525|MI0003152_5'Flank																	0						CTTTCTGTTGTCTGAAAGAAA	0.418													128	124	---	---	---	---	PASS
LILRA6	79168	broad.mit.edu	37	19	54742916	54742916	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:54742916C>A	uc002qeu.1	-	8	1483	c.1359G>T	c.(1357-1359)ATG>ATT	p.M453I	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Intron|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Intron|LILRA6_uc002qem.1_Intron|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Intron|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Intron|LILRB3_uc002qer.1_Intron|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Intron|LILRA6_uc010yeq.1_Intron|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Missense_Mutation_p.M297I	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	453	Helical; (Potential).					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCAAGCCTGCCATGCCCATGC	0.572													6	97	---	---	---	---	PASS
LILRA4	23547	broad.mit.edu	37	19	54848965	54848965	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:54848965C>A	uc002qfj.2	-	5	715	c.658G>T	c.(658-660)GTG>TTG	p.V220L	LILRA4_uc002qfi.2_Missense_Mutation_p.V154L	NM_012276	NP_036408	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor subfamily	220	Extracellular (Potential).					integral to membrane	receptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		TTCCTAGACACGCCTGGAGGG	0.597													9	11	---	---	---	---	PASS
LILRA2	11027	broad.mit.edu	37	19	55086465	55086465	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:55086465C>G	uc002qgg.3	+	4	709	c.620C>G	c.(619-621)TCT>TGT	p.S207C	LILRA2_uc010ern.2_Missense_Mutation_p.S207C|LILRA2_uc002qgf.2_Missense_Mutation_p.S207C|LILRA2_uc010yfe.1_Missense_Mutation_p.S207C|LILRA2_uc010yff.1_Missense_Mutation_p.S195C|LILRA2_uc010ero.2_Missense_Mutation_p.S195C|LILRA2_uc010yfg.1_Missense_Mutation_p.S207C	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	207	Extracellular (Potential).|Ig-like C2-type 2.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		TATGTGTGGTCTCTACCCAGT	0.587													97	73	---	---	---	---	PASS
NLRP4	147945	broad.mit.edu	37	19	56369120	56369120	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:56369120C>A	uc002qmd.3	+	3	783	c.361C>A	c.(361-363)CTA>ATA	p.L121I	NLRP4_uc002qmf.2_Missense_Mutation_p.L46I|NLRP4_uc010etf.2_5'UTR	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	121							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TGAGATTCACCTATACTTTGA	0.473													7	163	---	---	---	---	PASS
PEG3	5178	broad.mit.edu	37	19	57327637	57327637	+	Missense_Mutation	SNP	T	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:57327637T>C	uc002qnu.2	-	7	2524	c.2173A>G	c.(2173-2175)AGT>GGT	p.S725G	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.S696G|PEG3_uc002qnv.2_Missense_Mutation_p.S725G|PEG3_uc002qnw.2_Missense_Mutation_p.S601G|PEG3_uc002qnx.2_Missense_Mutation_p.S599G|PEG3_uc010etr.2_Missense_Mutation_p.S725G	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	725					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AATGGCCCACTATGAATGACA	0.433													31	74	---	---	---	---	PASS
ANGPT4	51378	broad.mit.edu	37	20	855022	855022	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr20:855022C>A	uc002wei.2	-	8	1359	c.1256G>T	c.(1255-1257)CGC>CTC	p.R419L	ANGPT4_uc010zpn.1_Intron	NM_015985	NP_057069	Q9Y264	ANGP4_HUMAN	angiopoietin 4 precursor	419	Fibrinogen C-terminal.				anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			ovary(2)	2						GCTGCTCTGGCGCCCTGCTGA	0.612													25	31	---	---	---	---	PASS
PROKR2	128674	broad.mit.edu	37	20	5283148	5283148	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr20:5283148C>A	uc010zqw.1	-	2	693	c.693G>T	c.(691-693)GAG>GAT	p.E231D	PROKR2_uc010zqx.1_Missense_Mutation_p.E231D|PROKR2_uc010zqy.1_Missense_Mutation_p.E231D	NM_144773	NP_658986	Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	231	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	neuropeptide Y receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5						GGCCCACGAACTCGACACCAA	0.547										HNSCC(71;0.22)			31	34	---	---	---	---	PASS
FERMT1	55612	broad.mit.edu	37	20	6078203	6078203	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr20:6078203C>T	uc002wmr.2	-	7	1714	c.925G>A	c.(925-927)GAG>AAG	p.E309K	FERMT1_uc010gbt.2_Missense_Mutation_p.E52K|FERMT1_uc002wms.2_Missense_Mutation_p.E309K|FERMT1_uc002wmt.2_Missense_Mutation_p.E52K	NM_017671	NP_060141	Q9BQL6	FERM1_HUMAN	kindlin-1	309	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			ovary(1)|pancreas(1)|skin(1)	3						ATTTCTTCCTCTGTGCAATCA	0.418													17	63	---	---	---	---	PASS
RRBP1	6238	broad.mit.edu	37	20	17641085	17641085	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr20:17641085A>C	uc010zrq.1	-	3	422	c.68T>G	c.(67-69)ATT>AGT	p.I23S	RRBP1_uc002wpu.2_5'Flank|RRBP1_uc002wpv.1_Missense_Mutation_p.I23S|RRBP1_uc002wpw.1_Missense_Mutation_p.I23S|RRBP1_uc010gcl.1_Intron|RRBP1_uc010zrr.1_Missense_Mutation_p.I23S			Q9P2E9	RRBP1_HUMAN	SubName: Full=RRBP1 protein; Flags: Fragment;	23	Helical; (Potential).				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			ovary(1)	1						GAAGATGCCAATGGCAGAAAC	0.473													31	47	---	---	---	---	PASS
RALGAPA2	57186	broad.mit.edu	37	20	20610174	20610174	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr20:20610174C>T	uc002wrz.2	-	10	1209	c.1066G>A	c.(1066-1068)GAG>AAG	p.E356K	RALGAPA2_uc010gcx.2_Missense_Mutation_p.E60K|RALGAPA2_uc010zsg.1_5'UTR	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	356					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						TTGTCCTGCTCCGTGGGCCCA	0.547													32	38	---	---	---	---	PASS
SSTR4	6754	broad.mit.edu	37	20	23016630	23016630	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr20:23016630G>A	uc002wsr.2	+	1	574	c.510G>A	c.(508-510)GTG>GTA	p.V170V		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	170	Helical; Name=4; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					ACCTGGGCGTGTGGCTGGCAT	0.697													11	38	---	---	---	---	PASS
TM9SF4	9777	broad.mit.edu	37	20	30745749	30745749	+	Silent	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr20:30745749G>A	uc002wxj.2	+	14	1717	c.1482G>A	c.(1480-1482)CGG>CGA	p.R494R	TM9SF4_uc010zts.1_Silent_p.R401R|TM9SF4_uc002wxk.2_Silent_p.R477R|TM9SF4_uc010gdz.2_Silent_p.R373R	NM_014742	NP_055557	Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	494						integral to membrane				central_nervous_system(1)|pancreas(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CCGAGCAGCGGTGGTACATGA	0.617													12	49	---	---	---	---	PASS
PTPRT	11122	broad.mit.edu	37	20	40864878	40864878	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr20:40864878G>C	uc002xkg.2	-	15	2517	c.2333C>G	c.(2332-2334)TCC>TGC	p.S778C	PTPRT_uc010ggj.2_Missense_Mutation_p.S797C	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	778	Cytoplasmic (Potential).				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CAAGTAATAGGAGTAGGAATA	0.388													17	70	---	---	---	---	PASS
CBLN4	140689	broad.mit.edu	37	20	54573767	54573767	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr20:54573767G>T	uc002xxa.2	-	3	1237	c.452C>A	c.(451-453)GCG>GAG	p.A151E		NM_080617	NP_542184	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	151	C1q.					cell junction|extracellular region|synapse				ovary(3)|pancreas(1)	4			Colorectal(105;0.202)			TTTGTCCCCCGCAAAGGCAGA	0.358													25	13	---	---	---	---	PASS
SFRS15	57466	broad.mit.edu	37	21	33044507	33044507	+	Silent	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr21:33044507C>T	uc002ypd.2	-	20	3075	c.2649G>A	c.(2647-2649)CCG>CCA	p.P883P	SFRS15_uc002ype.2_Silent_p.P861P|SFRS15_uc010glu.2_Silent_p.P868P	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	883						nucleus	nucleotide binding|RNA binding				0						GCATCATGTGCGGTGGCATGG	0.642													25	10	---	---	---	---	PASS
SFRS15	57466	broad.mit.edu	37	21	33058012	33058012	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr21:33058012C>A	uc002ypd.2	-	17	2504	c.2078G>T	c.(2077-2079)GGT>GTT	p.G693V	SFRS15_uc002ype.2_Missense_Mutation_p.G693V|SFRS15_uc010glu.2_Missense_Mutation_p.G678V|SFRS15_uc002ypf.1_Missense_Mutation_p.G367V	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	693						nucleus	nucleotide binding|RNA binding				0						CTGGAGAGCACCAACTACAGG	0.547													17	10	---	---	---	---	PASS
SON	6651	broad.mit.edu	37	21	34926741	34926741	+	Missense_Mutation	SNP	G	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr21:34926741G>A	uc002yse.1	+	3	5253	c.5204G>A	c.(5203-5205)AGA>AAA	p.R1735K	SON_uc002ysb.1_Missense_Mutation_p.R1735K|SON_uc002ysc.2_Missense_Mutation_p.R1735K|SON_uc002ysd.2_Missense_Mutation_p.R726K|SON_uc002ysf.1_Intron|SON_uc002ysg.2_Missense_Mutation_p.R726K	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	1735					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GATTTAGTGAGACCGTTACTT	0.448													17	80	---	---	---	---	PASS
FTCD	10841	broad.mit.edu	37	21	47571482	47571482	+	Missense_Mutation	SNP	C	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr21:47571482C>G	uc002zif.2	-	5	670	c.626G>C	c.(625-627)GGG>GCG	p.G209A	FTCD_uc002zig.2_Missense_Mutation_p.G209A|FTCD_uc002zih.2_Missense_Mutation_p.G209A|FTCD_uc010gqf.2_Missense_Mutation_p.G209A|FTCD_uc010gqg.1_Missense_Mutation_p.G78A	NM_006657	NP_006648	O95954	FTCD_HUMAN	formiminotransferase cyclodeaminase	209	Formiminotransferase C-subdomain (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			pancreas(1)|skin(1)	2	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CTGGTCCTTCCCGCGGCCCTG	0.652													11	7	---	---	---	---	PASS
AIFM3	150209	broad.mit.edu	37	22	21330039	21330039	+	Missense_Mutation	SNP	A	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr22:21330039A>G	uc002ztj.2	+	9	997	c.779A>G	c.(778-780)TAT>TGT	p.Y260C	AIFM3_uc002ztk.2_Missense_Mutation_p.Y260C|AIFM3_uc002ztl.2_Missense_Mutation_p.Y266C|AIFM3_uc011ahx.1_Missense_Mutation_p.Y248C|AIFM3_uc002ztm.1_Missense_Mutation_p.Y72C	NM_144704	NP_653305	Q96NN9	AIFM3_HUMAN	apoptosis-inducing factor,	260					activation of caspase activity by cytochrome c|cell redox homeostasis|electron transport chain|induction of apoptosis|mitochondrial depolarization|transport	endoplasmic reticulum|mitochondrial inner membrane	2 iron, 2 sulfur cluster binding|caspase activator activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity|protein binding			ovary(2)|lung(2)	4	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TTCCGAGCCTATGGCATCGAG	0.592													8	55	---	---	---	---	PASS
C22orf13	83606	broad.mit.edu	37	22	24943946	24943946	+	Missense_Mutation	SNP	A	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr22:24943946A>C	uc003aah.2	-	3	540	c.224T>G	c.(223-225)ATG>AGG	p.M75R	C22orf13_uc003aal.2_Missense_Mutation_p.M131R|C22orf13_uc003aai.3_Missense_Mutation_p.M75R|C22orf13_uc003aaj.3_Missense_Mutation_p.M75R|C22orf13_uc003aak.3_Missense_Mutation_p.M131R	NM_031444	NP_113632	Q96NT3	CV013_HUMAN	chromosome 22 open reading frame 13	75											0						AAAGTGGTGCATCAGGTAGGC	0.607													32	42	---	---	---	---	PASS
GAS2L1	10634	broad.mit.edu	37	22	29706908	29706908	+	Silent	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr22:29706908G>C	uc003afa.1	+	5	1129	c.930G>C	c.(928-930)GGG>GGC	p.G310G	GAS2L1_uc010gvm.1_Silent_p.G310G|GAS2L1_uc003afb.1_Silent_p.G310G|GAS2L1_uc003afc.1_Silent_p.G310G|GAS2L1_uc003afd.1_Silent_p.G310G|GAS2L1_uc003afe.1_Silent_p.G310G	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	310					cell cycle arrest	cytoplasm|cytoskeleton					0						CAGTCCCTGGGAGTGAGCGCC	0.672													35	37	---	---	---	---	PASS
NEFH	4744	broad.mit.edu	37	22	29885319	29885319	+	Missense_Mutation	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr22:29885319G>C	uc003afo.2	+	4	1761	c.1690G>C	c.(1690-1692)GCC>CCC	p.A564P	NEFH_uc003afp.2_Intron	NM_021076	NP_066554	P12036	NFH_HUMAN	neurofilament, heavy polypeptide 200kDa	564	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|5.|Tail.				cell death|nervous system development	neurofilament					0						ACCGCCTGAGGCCAAGTCCCC	0.567													20	145	---	---	---	---	PASS
LARGE	9215	broad.mit.edu	37	22	33733695	33733695	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr22:33733695G>T	uc003and.3	-	11	1803	c.1224C>A	c.(1222-1224)GAC>GAA	p.D408E	LARGE_uc011amd.1_Missense_Mutation_p.D207E|LARGE_uc003ane.3_Missense_Mutation_p.D408E|LARGE_uc010gwp.2_Intron|LARGE_uc011ame.1_Missense_Mutation_p.D340E|LARGE_uc011amf.1_Missense_Mutation_p.D408E|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	408	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				GAAGATTGCCGTCATACTCCA	0.562													15	30	---	---	---	---	PASS
L3MBTL2	83746	broad.mit.edu	37	22	41605724	41605724	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr22:41605724G>T	uc003azo.2	+	2	103	c.49G>T	c.(49-51)GAG>TAG	p.E17*	L3MBTL2_uc010gyi.1_5'UTR|L3MBTL2_uc003azn.2_RNA|uc003azp.1_RNA	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	17	Poly-Glu.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						AGAACCAATGGAGGAAGAGGA	0.488													6	181	---	---	---	---	PASS
SCUBE1	80274	broad.mit.edu	37	22	43614411	43614411	+	Missense_Mutation	SNP	C	A	A	rs139119420		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr22:43614411C>A	uc003bdt.1	-	15	1829	c.1741G>T	c.(1741-1743)GCC>TCC	p.A581S		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	581					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				GTCTTGATGGCGGCCTGCAGG	0.607													45	72	---	---	---	---	PASS
TUBGCP6	85378	broad.mit.edu	37	22	50682676	50682676	+	Silent	SNP	G	C	C			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr22:50682676G>C	uc003bkb.1	-	1	725	c.213C>G	c.(211-213)CTC>CTG	p.L71L	TUBGCP6_uc010har.1_Silent_p.L71L|TUBGCP6_uc010has.1_RNA|TUBGCP6_uc010hau.1_Silent_p.L71L	NM_020461	NP_065194	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	71					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			ovary(2)|central_nervous_system(2)	4		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGGACAACATGAGGATCTTGT	0.517													8	77	---	---	---	---	PASS
GPR64	10149	broad.mit.edu	37	X	19025356	19025356	+	Missense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chrX:19025356G>T	uc004cyx.2	-	20	1850	c.1686C>A	c.(1684-1686)AGC>AGA	p.S562R	GPR64_uc004cyy.2_Missense_Mutation_p.S559R|GPR64_uc004cyz.2_Missense_Mutation_p.S548R|GPR64_uc004czb.2_Missense_Mutation_p.S562R|GPR64_uc004czc.2_Missense_Mutation_p.S546R|GPR64_uc004czd.2_Missense_Mutation_p.S538R|GPR64_uc004cze.2_Missense_Mutation_p.S532R|GPR64_uc004czf.2_Missense_Mutation_p.S524R|GPR64_uc004cza.2_Missense_Mutation_p.S540R|GPR64_uc004cyw.2_Missense_Mutation_p.S546R|GPR64_uc010nfj.2_Intron	NM_001079858	NP_001073327	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64 isoform 1	562	Extracellular (Potential).				neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity				0	Hepatocellular(33;0.183)					TCCCCACCTGGCTCGGGTTGA	0.498													16	10	---	---	---	---	PASS
PRDX4	10549	broad.mit.edu	37	X	23689672	23689672	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chrX:23689672G>T	uc004dam.2	+	2	311	c.268G>T	c.(268-270)GGA>TGA	p.G90*		NM_006406	NP_006397	Q13162	PRDX4_HUMAN	peroxiredoxin 4	90	Thioredoxin.				cell redox homeostasis|I-kappaB phosphorylation		thioredoxin peroxidase activity			upper_aerodigestive_tract(1)	1						CTACTGGGAAGGAACAGCTGT	0.383													4	33	---	---	---	---	PASS
MAGEB6	158809	broad.mit.edu	37	X	26212607	26212607	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chrX:26212607C>A	uc004dbr.2	+	2	793	c.644C>A	c.(643-645)TCC>TAC	p.S215Y	MAGEB6_uc010ngc.1_5'UTR	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	215	MAGE.									ovary(3)	3						AAGAAAGAGTCCATTTTGAAG	0.468													26	32	---	---	---	---	PASS
MAGEB4	4115	broad.mit.edu	37	X	30260685	30260685	+	Nonsense_Mutation	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chrX:30260685G>T	uc004dcb.2	+	1	517	c.433G>T	c.(433-435)GAG>TAG	p.E145*	MAGEB1_uc004dcc.2_5'Flank|MAGEB1_uc004dcd.2_5'Flank	NM_002367	NP_002358	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	145	MAGE.									ovary(1)	1						AAAGTACAAGGAGCACTTCCC	0.478													6	9	---	---	---	---	PASS
KDM6A	7403	broad.mit.edu	37	X	44922694	44922694	+	Nonsense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chrX:44922694C>T	uc004dge.3	+	16	1930	c.1555C>T	c.(1555-1557)CGA>TGA	p.R519*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.R485*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.R571*|KDM6A_uc011mla.1_Nonsense_Mutation_p.R474*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.R526*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.R223*|KDM6A_uc011mld.1_Nonsense_Mutation_p.R158*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	519					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TGCACAGGTACGATCTACTGG	0.463			D|N|F|S		renal|oesophageal SCC|MM								26	18	---	---	---	---	PASS
SPIN4	139886	broad.mit.edu	37	X	62570653	62570653	+	Missense_Mutation	SNP	C	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chrX:62570653C>T	uc004dvf.2	-	1	566	c.46G>A	c.(46-48)GCA>ACA	p.A16T		NM_001012968	NP_001012986	Q56A73	SPIN4_HUMAN	spindlin family, member 4	16					gamete generation					ovary(1)|lung(1)	2						ATCAGGTATGCGGACACGCCA	0.567													9	13	---	---	---	---	PASS
RAB41	347517	broad.mit.edu	37	X	69502420	69502420	+	Missense_Mutation	SNP	C	G	G	rs140771923		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chrX:69502420C>G	uc004dyc.2	+	2	162	c.162C>G	c.(160-162)AAC>AAG	p.N54K	RAB41_uc010nkv.2_Missense_Mutation_p.N43K	NM_001032726	NP_001027898	Q5JT25	RAB41_HUMAN	RAB41, member RAS oncogene family	54					protein transport|small GTPase mediated signal transduction		GTP binding			ovary(2)|breast(2)	4						TCATGTACAACAGCTTCGGCT	0.527													9	4	---	---	---	---	PASS
ZMYM3	9203	broad.mit.edu	37	X	70464694	70464694	+	Silent	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chrX:70464694C>A	uc004dzh.1	-	19	3144	c.3057G>T	c.(3055-3057)CTG>CTT	p.L1019L	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Silent_p.L1019L|ZMYM3_uc004dzj.1_Silent_p.L1007L	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	1019					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					CAGGCCCTACCAGGCCACAAT	0.453													4	18	---	---	---	---	PASS
ZCCHC12	170261	broad.mit.edu	37	X	117959988	117959988	+	Missense_Mutation	SNP	T	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chrX:117959988T>A	uc004equ.2	+	4	1254	c.781T>A	c.(781-783)TGC>AGC	p.C261S		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						CAGTGCTGACTGCAATGTGAT	0.557													18	19	---	---	---	---	PASS
FRMD7	90167	broad.mit.edu	37	X	131219751	131219751	+	Missense_Mutation	SNP	C	A	A			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chrX:131219751C>A	uc004ewn.2	-	7	681	c.503G>T	c.(502-504)AGG>ATG	p.R168M	FRMD7_uc011muy.1_Missense_Mutation_p.R153M	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	168	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					AGCTGGGCTCCTGCCACTGAA	0.502													4	20	---	---	---	---	PASS
MIR888	100126306	broad.mit.edu	37	X	145076364	145076364	+	RNA	SNP	G	T	T			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chrX:145076364G>T	hsa-mir-888|MI0005537	-			c.15G>T			MIR890_hsa-mir-890|MI0005533_5'Flank																	0						ACAGCTTTTTGAGTAGAGCAC	0.498													12	4	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	1	16889470	16889472	+	RNA	DEL	ACA	-	-	rs35438508		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:16889470_16889472delACA	uc001ayw.2	-	1		c.611_613delTGT								Homo sapiens AB5 mRNA, 3' untranslated region.																		accatcaatgacaacaacaaaaa	0.074													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	1	84042375	84042376	+	RNA	INS	-	T	T	rs112376435		TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:84042375_84042376insT	uc001diz.3	-	3		c.2260_2261insA								Homo sapiens cDNA clone IMAGE:4815396.																		cttttgtgcacttttttttttt	0.000													4	2	---	---	---	---	
LOC149134	149134	broad.mit.edu	37	1	246939610	246939611	+	RNA	INS	-	TATT	TATT	rs149331399	by1000genomes	TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr1:246939610_246939611insTATT	uc001ibs.1	+	1		c.296_297insTATT								Homo sapiens cDNA FLJ12763 fis, clone NT2RP2001450.												0						GGGCATCTCTATATTTATTTTG	0.460													3	4	---	---	---	---	
Unknown	0	broad.mit.edu	37	3	195438500	195438502	+	RNA	DEL	AAG	-	-			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr3:195438500_195438502delAAG	uc003fux.1	+	3		c.2487_2489delAAG								Homo sapiens cDNA FLJ46488 fis, clone THYMU3026869.																		GAGGAGAATAAAGAAGAGAGCCT	0.567													7	5	---	---	---	---	
ZSWIM6	57688	broad.mit.edu	37	5	60831400	60831400	+	Frame_Shift_Del	DEL	C	-	-			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr5:60831400delC	uc003jsr.2	+	10	2335	c.2335delC	c.(2335-2337)CCTfs	p.P779fs		NM_020928	NP_065979	Q9HCJ5	ZSWM6_HUMAN	zinc finger, SWIM-type containing 6	779							zinc ion binding				0						CTCTCTCCTACCTCACGATGC	0.502													4	2	---	---	---	---	
PKHD1L1	93035	broad.mit.edu	37	8	110461578	110461578	+	Frame_Shift_Del	DEL	G	-	-			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr8:110461578delG	uc003yne.2	+	40	6141	c.6037delG	c.(6037-6039)GGGfs	p.G2013fs		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2013	Extracellular (Potential).|IPT/TIG 13.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GAGCTTTGGTGGGGGTCAAAC	0.333										HNSCC(38;0.096)			20	12	---	---	---	---	
CDKN2A	1029	broad.mit.edu	37	9	21971019	21971019	+	Frame_Shift_Del	DEL	C	-	-			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr9:21971019delC	uc003zpk.2	-	2	551	c.339delG	c.(337-339)CTGfs	p.L113fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Frame_Shift_Del_p.A169fs	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	113	ANK 4.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.H83fs*2(2)|p.L113L(1)|p.L113M(1)|p.A68fs*3(1)|p.L113P(1)|p.R112fs*32(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GGTCCACGGGCAGACGGCCCC	0.726		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			7	5	---	---	---	---	
C10orf110	55853	broad.mit.edu	37	10	1089534	1089534	+	Frame_Shift_Del	DEL	A	-	-			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:1089534delA	uc001ifw.3	+	4	481	c.479delA	c.(478-480)GAAfs	p.E160fs	C10orf110_uc010qaf.1_RNA|C10orf110_uc001ifx.3_RNA|C10orf110_uc001ify.3_RNA|IDI1_uc001ifz.2_Intron|IDI1_uc001iga.2_Intron|IDI1_uc001igb.2_Intron|IDI1_uc001igc.2_Intron	NR_024628				Homo sapiens uncharacterized hypothalamus protein HT009 mRNA, complete cds.												0						CGAGTGAAGGAAATGGTGATG	0.517													4	2	---	---	---	---	
ANXA11	311	broad.mit.edu	37	10	81928846	81928847	+	Frame_Shift_Ins	INS	-	G	G			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr10:81928846_81928847insG	uc001kbq.1	-	6	1264_1265	c.439_440insC	c.(439-441)CAGfs	p.Q147fs	ANXA11_uc010qlx.1_Frame_Shift_Ins_p.Q247fs|ANXA11_uc001kbr.1_Frame_Shift_Ins_p.Q147fs|ANXA11_uc001kbs.1_Frame_Shift_Ins_p.Q147fs|ANXA11_uc001kbt.1_Frame_Shift_Ins_p.Q147fs|ANXA11_uc010qly.1_Frame_Shift_Ins_p.Q114fs|ANXA11_uc009xsq.1_Frame_Shift_Ins_p.Q147fs|ANXA11_uc001kbu.1_Frame_Shift_Ins_p.Q147fs	NM_145869	NP_665876	P50995	ANX11_HUMAN	annexin A11	147					cell cycle|cytokinesis, completion of separation|phagocytosis|response to calcium ion	azurophil granule|melanosome|midbody|nuclear envelope|nucleoplasm|phagocytic vesicle|specific granule|spindle	calcium-dependent phospholipid binding|calcium-dependent protein binding|S100 alpha binding			ovary(1)	1	Prostate(51;0.00985)|all_epithelial(25;0.0951)		Colorectal(32;0.109)			CACTGGTGGCTGCCCAGGGTAG	0.698													4	2	---	---	---	---	
Unknown	0	broad.mit.edu	37	12	52501561	52501562	+	RNA	INS	-	T	T	rs145272216	by1000genomes	TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr12:52501561_52501562insT	uc009zme.1	+	3		c.960_961insT								Homo sapiens olfactory receptor, family 7, subfamily E, member 47 pseudogene, mRNA (cDNA clone IMAGE:5590288).																		GTTTTGCTGTCTTTTTTTTTTC	0.436													4	2	---	---	---	---	
NRN1L	123904	broad.mit.edu	37	16	67920066	67920068	+	In_Frame_Del	DEL	GCT	-	-			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr16:67920066_67920068delGCT	uc002euu.2	+	3	428_430	c.402_404delGCT	c.(400-405)ACGCTG>ACG	p.L135del	EDC4_uc002eut.1_3'UTR	NM_198443	NP_940845	Q496H8	NRN1L_HUMAN	neuritin 1-like precursor	135						anchored to membrane|plasma membrane				central_nervous_system(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00415)|Epithelial(162;0.0182)|all cancers(182;0.119)		ACCAGGAGACGCTGCGGGCTACA	0.675													7	9	---	---	---	---	
LOC651250	651250	broad.mit.edu	37	17	66122028	66122029	+	RNA	DEL	AA	-	-			TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr17:66122028_66122029delAA	uc002jgq.2	+	6		c.1151_1152delAA			LOC651250_uc002kit.2_RNA|LOC651250_uc002jgo.1_Intron	NR_027418				Homo sapiens cDNA FLJ33831 fis, clone CTONG2003937.												0						TTCGTGAGCTaaaaaaaaaaaa	0.267													4	2	---	---	---	---	
ZNF808	388558	broad.mit.edu	37	19	53066664	53066665	+	RNA	INS	-	AGTA	AGTA	rs151076736	by1000genomes	TCGA-18-3411-01A-01D-0983-08	TCGA-18-3411-11A-01D-0983-08									Somatic	Phase_I	Capture				Illumina GAIIx	6a9cc303-c7fd-4f40-8933-1636dea99252	5d18da80-61b7-438b-9ad1-ac2e98d0e820	g.chr19:53066664_53066665insAGTA	uc002pzq.2	+	4		c.3176_3177insAGTA						Q8N4W9	ZN808_HUMAN	Homo sapiens zinc finger protein 808, mRNA (cDNA clone IMAGE:3542548), complete cds.						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		cacatgcctgcagtatcaacta	0.045													4	2	---	---	---	---