Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
DEPDC1	55635	broad.mit.edu	37	1	68948029	68948029	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:68948029T>C	uc001dem.3	-	8	1579	c.1462A>G	c.(1462-1464)ACT>GCT	p.T488A	DEPDC1_uc001dej.3_5'Flank|DEPDC1_uc001dek.3_Intron|DEPDC1_uc001del.3_Intron	NM_001114120	NP_001107592	Q5TB30	DEP1A_HUMAN	DEP domain containing 1 isoform a	488					intracellular signal transduction|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	GTPase activator activity|protein binding				0				OV - Ovarian serous cystadenocarcinoma(397;7.21e-36)		ACAGTCAAAGTAGAGGTTCTC	0.378													16	43	---	---	---	---	PASS
C1orf173	127254	broad.mit.edu	37	1	75107143	75107143	+	Nonsense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:75107143C>A	uc001dgg.2	-	5	535	c.316G>T	c.(316-318)GGA>TGA	p.G106*		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	106										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GTGTGCTCTCCCTAGAATAAG	0.393													5	49	---	---	---	---	PASS
C1orf173	127254	broad.mit.edu	37	1	75107144	75107144	+	Splice_Site	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:75107144C>G	uc001dgg.2	-	5	535	c.316_splice	c.e5-1	p.G106_splice		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254											ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TGTGCTCTCCCTAGAATAAGA	0.393													5	49	---	---	---	---	PASS
FAM73A	374986	broad.mit.edu	37	1	78324687	78324687	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:78324687A>G	uc001dhx.2	+	9	1093	c.1061A>G	c.(1060-1062)TAC>TGC	p.Y354C	FAM73A_uc010ork.1_Missense_Mutation_p.Y354C|FAM73A_uc010orl.1_Missense_Mutation_p.Y316C|FAM73A_uc001dhy.1_Missense_Mutation_p.Y143C	NM_198549	NP_940951	Q8NAN2	FA73A_HUMAN	hypothetical protein LOC374986	354						integral to membrane				ovary(1)	1				Colorectal(170;0.226)		TGCCCATTTTACGAGGAAGCC	0.403													5	79	---	---	---	---	PASS
ATP8B2	57198	broad.mit.edu	37	1	154316660	154316660	+	Silent	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:154316660G>T	uc001fex.2	+	19	2064	c.2064G>T	c.(2062-2064)GGG>GGT	p.G688G		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	674	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TTCAGCAAGGGGTTCCAGAGA	0.557													7	66	---	---	---	---	PASS
DCST1	149095	broad.mit.edu	37	1	155014074	155014074	+	Missense_Mutation	SNP	A	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:155014074A>C	uc001fgn.1	+	7	829	c.733A>C	c.(733-735)AAG>CAG	p.K245Q	DCST1_uc010per.1_Missense_Mutation_p.K270Q|DCST1_uc010pes.1_Missense_Mutation_p.K220Q	NM_152494	NP_689707	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1 isoform 1	245	Extracellular (Potential).					integral to membrane	zinc ion binding			ovary(1)|skin(1)	2	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GCTGAAGACCAAGCTGCGTTG	0.612													17	71	---	---	---	---	PASS
DARC	2532	broad.mit.edu	37	1	159175347	159175347	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:159175347G>C	uc001fto.2	+	2	358	c.118G>C	c.(118-120)GAC>CAC	p.D40H	DARC_uc001ftp.3_Missense_Mutation_p.D42H	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	40	Extracellular (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					CCCAGATGGAGACTATGGTGC	0.537													8	89	---	---	---	---	PASS
SLAMF8	56833	broad.mit.edu	37	1	159799706	159799706	+	Missense_Mutation	SNP	G	A	A	rs138614766		TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:159799706G>A	uc001fue.3	+	2	301	c.91G>A	c.(91-93)GGC>AGC	p.G31S		NM_020125	NP_064510	Q9P0V8	SLAF8_HUMAN	SLAM family member 8 precursor	31	Extracellular (Potential).					integral to membrane					0	all_hematologic(112;0.0597)					CAAAGTCGGGGGCTCGGTGCT	0.597													9	229	---	---	---	---	PASS
F5	2153	broad.mit.edu	37	1	169489877	169489877	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:169489877G>T	uc001ggg.1	-	22	6219	c.6074C>A	c.(6073-6075)TCT>TAT	p.S2025Y		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	2025	F5/8 type C 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTTTATTGTAGAGGCATCTGA	0.333													8	58	---	---	---	---	PASS
F5	2153	broad.mit.edu	37	1	169511269	169511269	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:169511269A>G	uc001ggg.1	-	13	3204	c.3059T>C	c.(3058-3060)CTG>CCG	p.L1020P		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1020	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GCTTTTCTTCAGTCTACTCTT	0.433													45	260	---	---	---	---	PASS
SERPINC1	462	broad.mit.edu	37	1	173880956	173880956	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:173880956A>G	uc001gjt.2	-	3	724	c.605T>C	c.(604-606)CTC>CCC	p.L202P		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	202					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	CAGGGGCTGGAGCTTGGCTCC	0.493													32	117	---	---	---	---	PASS
SERPINC1	462	broad.mit.edu	37	1	173880990	173880990	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:173880990G>C	uc001gjt.2	-	3	690	c.571C>G	c.(571-573)CAG>GAG	p.Q191E		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	191					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	CTGATGTCCTGGTAGGTCTCA	0.488													34	125	---	---	---	---	PASS
RC3H1	149041	broad.mit.edu	37	1	173962058	173962058	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:173962058G>A	uc001gju.3	-	1	153	c.66C>T	c.(64-66)GAC>GAT	p.D22D	RC3H1_uc010pms.1_Silent_p.D22D|RC3H1_uc001gjv.2_Silent_p.D22D|RC3H1_uc010pmt.1_Silent_p.D22D	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	22	RING-type; degenerate.				cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						GAATTGTTTCGTCGAAAGTCT	0.478													4	111	---	---	---	---	PASS
C1orf125	126859	broad.mit.edu	37	1	179460734	179460734	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:179460734C>T	uc001gmo.2	+	19	2280	c.2153C>T	c.(2152-2154)CCC>CTC	p.P718L	C1orf125_uc009wxg.2_RNA|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.P718L|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	718											0						TTAATGATACCCAACTTTACT	0.378													7	92	---	---	---	---	PASS
F13B	2165	broad.mit.edu	37	1	197026480	197026480	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:197026480C>T	uc001gtt.1	-	6	965	c.921G>A	c.(919-921)GAG>GAA	p.E307E		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	307	Sushi 5.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ACCCATGGATCTCAAAATTAA	0.378													21	126	---	---	---	---	PASS
SYT2	127833	broad.mit.edu	37	1	202572227	202572227	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:202572227G>A	uc001gye.2	-	4	558	c.365C>T	c.(364-366)ACA>ATA	p.T122I	SYT2_uc010pqb.1_Missense_Mutation_p.T122I|SYT2_uc009xaf.2_5'UTR	NM_001136504	NP_001129976	Q8N9I0	SYT2_HUMAN	synaptotagmin II	122	Cytoplasmic (Potential).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	AGTCAGGCCTGTCTCTGCGTC	0.552													4	129	---	---	---	---	PASS
PLXNA2	5362	broad.mit.edu	37	1	208390594	208390594	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:208390594A>G	uc001hgz.2	-	2	1432	c.674T>C	c.(673-675)CTC>CCC	p.L225P	PLXNA2_uc001hha.3_Missense_Mutation_p.L279P	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	225	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		GATCTTGATGAGAGAGGAGAC	0.542													16	301	---	---	---	---	PASS
INTS7	25896	broad.mit.edu	37	1	212149931	212149931	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:212149931G>T	uc001hiw.1	-	12	1706	c.1601C>A	c.(1600-1602)TCC>TAC	p.S534Y	INTS7_uc009xdb.1_Missense_Mutation_p.S534Y|INTS7_uc001hix.1_Missense_Mutation_p.S410Y|INTS7_uc001hiy.1_Missense_Mutation_p.S534Y|INTS7_uc010pta.1_Missense_Mutation_p.S485Y	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	534					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		TACCATTCTGGAAGCCTGTCT	0.403													5	135	---	---	---	---	PASS
ESRRG	2104	broad.mit.edu	37	1	216737588	216737588	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:216737588T>C	uc001hkw.1	-	5	1001	c.835A>G	c.(835-837)ATC>GTC	p.I279V	ESRRG_uc001hky.1_Missense_Mutation_p.I256V|ESRRG_uc009xdp.1_Missense_Mutation_p.I256V|ESRRG_uc001hkz.1_Missense_Mutation_p.I217V|ESRRG_uc010puc.1_Missense_Mutation_p.I256V|ESRRG_uc001hla.1_Missense_Mutation_p.I256V|ESRRG_uc001hlb.1_Missense_Mutation_p.I256V|ESRRG_uc010pud.1_Missense_Mutation_p.I87V|ESRRG_uc001hlc.1_Missense_Mutation_p.I256V|ESRRG_uc001hld.1_Missense_Mutation_p.I256V|ESRRG_uc001hkx.1_Missense_Mutation_p.I291V|ESRRG_uc009xdo.1_Missense_Mutation_p.I256V|ESRRG_uc001hle.1_Missense_Mutation_p.I256V	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	279					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CATCCAATGATAACCACCAAC	0.443													15	58	---	---	---	---	PASS
SIPA1L2	57568	broad.mit.edu	37	1	232649736	232649736	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:232649736G>A	uc001hvg.2	-	1	1508	c.1350C>T	c.(1348-1350)TGC>TGT	p.C450C		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	450					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CTGCATTTGTGCAGTGAGAGC	0.527													33	224	---	---	---	---	PASS
HEATR1	55127	broad.mit.edu	37	1	236736089	236736089	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:236736089G>C	uc001hyd.1	-	25	3624	c.3499C>G	c.(3499-3501)CCA>GCA	p.P1167A	HEATR1_uc009xgh.1_Missense_Mutation_p.P329A	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	1167					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTATCTGGTGGCTCCAGTTCT	0.383													40	346	---	---	---	---	PASS
ACTN2	88	broad.mit.edu	37	1	236889288	236889288	+	Silent	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:236889288T>C	uc001hyf.2	+	5	708	c.504T>C	c.(502-504)TAT>TAC	p.Y168Y	ACTN2_uc001hyg.2_5'UTR|ACTN2_uc009xgi.1_Silent_p.Y168Y	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	168	CH 2.|Actin-binding.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CTGCTCCTTATAGAAATGTGA	0.483													25	179	---	---	---	---	PASS
KIF26B	55083	broad.mit.edu	37	1	245850124	245850124	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:245850124C>G	uc001ibf.1	+	12	4279	c.3839C>G	c.(3838-3840)TCC>TGC	p.S1280C	KIF26B_uc001ibg.1_Missense_Mutation_p.S898C|KIF26B_uc001ibh.1_Missense_Mutation_p.S522C	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1280					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			TCCATCAGCTCCTGGCTGAGC	0.612													4	35	---	---	---	---	PASS
OR11L1	391189	broad.mit.edu	37	1	248005145	248005145	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:248005145C>T	uc001idn.1	-	1	54	c.54G>A	c.(52-54)CAG>CAA	p.Q18Q		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CAAGAAGGTTCTGGAATCCTA	0.483													8	61	---	---	---	---	PASS
HEATR5B	54497	broad.mit.edu	37	2	37259800	37259800	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:37259800A>T	uc002rpp.1	-	22	3429	c.3333T>A	c.(3331-3333)AAT>AAA	p.N1111K		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1111							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				TGTCCCCTGTATTTTTTGCCA	0.388													19	89	---	---	---	---	PASS
DHX57	90957	broad.mit.edu	37	2	39025486	39025486	+	Silent	SNP	T	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:39025486T>G	uc002rrf.2	-	24	4215	c.4116A>C	c.(4114-4116)GGA>GGC	p.G1372G	DHX57_uc002rrd.3_Silent_p.G711G|DHX57_uc002rre.2_Silent_p.G805G	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	1372							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				TGATCCGGGATCCTCGAGGAC	0.453													6	134	---	---	---	---	PASS
CHAC2	494143	broad.mit.edu	37	2	54001452	54001452	+	Silent	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:54001452T>C	uc002rxk.1	+	3	440	c.345T>C	c.(343-345)AAT>AAC	p.N115N	ASB3_uc002rxg.1_Intron|ASB3_uc002rxh.1_Intron|ASB3_uc002rxi.3_Intron|ASB3_uc010yoo.1_Intron	NM_001008708	NP_001008708	Q8WUX2	CHAC2_HUMAN	ChaC, cation transport regulator-like 2	115											0			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			CATGTGATAATCCTGATTATC	0.368													5	127	---	---	---	---	PASS
LRRTM1	347730	broad.mit.edu	37	2	80530036	80530036	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:80530036C>G	uc002sok.1	-	2	1179	c.909G>C	c.(907-909)TGG>TGC	p.W303C	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	303	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						TCAGGGACTTCCAAGAGTTGA	0.627										HNSCC(69;0.2)			12	46	---	---	---	---	PASS
CTNNA2	1496	broad.mit.edu	37	2	80874960	80874960	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:80874960A>T	uc010ysh.1	+	18	2830	c.2825A>T	c.(2824-2826)CAG>CTG	p.Q942L	CTNNA2_uc010yse.1_Missense_Mutation_p.Q894L|CTNNA2_uc010ysf.1_Missense_Mutation_p.Q894L|CTNNA2_uc010ysg.1_Missense_Mutation_p.Q849L|CTNNA2_uc010ysi.1_Missense_Mutation_p.Q526L|CTNNA2_uc010ysj.1_Missense_Mutation_p.Q223L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	942					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TCGCCTGTACAGGCTTTAAGT	0.353													38	149	---	---	---	---	PASS
SMYD1	150572	broad.mit.edu	37	2	88396294	88396294	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:88396294C>G	uc002ssr.2	+	6	881	c.879C>G	c.(877-879)GAC>GAG	p.D293E	SMYD1_uc002ssq.1_Intron|SMYD1_uc002sss.2_5'UTR	NM_198274	NP_938015	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)|skin(1)	4						GGGTGAAAGACAACCCCAAGG	0.527													9	57	---	---	---	---	PASS
TRIM43	129868	broad.mit.edu	37	2	96260870	96260870	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:96260870G>A	uc002suv.2	+	3	620	c.484G>A	c.(484-486)GGA>AGA	p.G162R		NM_138800	NP_620155	Q96BQ3	TRI43_HUMAN	tripartite motif-containing 43	162						intracellular	zinc ion binding			ovary(1)	1						ATATGAGGAGGGAAGAACAGC	0.398													5	50	---	---	---	---	PASS
SMPD4	55627	broad.mit.edu	37	2	130929950	130929950	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:130929950C>T	uc002tqq.1	-	8	1268	c.748G>A	c.(748-750)GGG>AGG	p.G250R	SMPD4_uc002tqp.1_5'UTR|SMPD4_uc010yzy.1_Intron|SMPD4_uc010yzz.1_Intron|SMPD4_uc002tqr.1_Missense_Mutation_p.G250R|SMPD4_uc002tqs.1_Missense_Mutation_p.G118R|SMPD4_uc002tqt.1_Missense_Mutation_p.G128R|SMPD4_uc010zaa.1_Missense_Mutation_p.G137R|SMPD4_uc010zab.1_Missense_Mutation_p.G177R|SMPD4_uc010zac.1_Intron|SMPD4_uc010zad.1_Intron	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	211					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	CTGGTCCCCCCTGGGCTGGAG	0.617													14	58	---	---	---	---	PASS
LCT	3938	broad.mit.edu	37	2	136566975	136566975	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:136566975G>T	uc002tuu.1	-	8	2953	c.2942C>A	c.(2941-2943)TCT>TAT	p.S981Y		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	981	3.|Extracellular (Potential).|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GAAAATCCGAGACCAGGAGAT	0.498													16	101	---	---	---	---	PASS
GALNT13	114805	broad.mit.edu	37	2	155098562	155098562	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:155098562C>G	uc002tyr.3	+	5	898	c.331C>G	c.(331-333)CCT>GCT	p.P111A	GALNT13_uc002tyt.3_Missense_Mutation_p.P111A|GALNT13_uc010foc.1_5'UTR	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	111	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						AAAAGTCTACCCTGATGAACT	0.328													5	56	---	---	---	---	PASS
KCNJ3	3760	broad.mit.edu	37	2	155711690	155711690	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:155711690G>T	uc002tyv.1	+	3	1566	c.1371G>T	c.(1369-1371)AAG>AAT	p.K457N	KCNJ3_uc010zce.1_3'UTR	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	457	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	AAACCACCAAGATGTTATCTG	0.473													4	74	---	---	---	---	PASS
RAPGEF4	11069	broad.mit.edu	37	2	173853511	173853511	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:173853511G>A	uc002uhv.3	+	14	1505	c.1318G>A	c.(1318-1320)GAA>AAA	p.E440K	RAPGEF4_uc002uhw.3_Missense_Mutation_p.E296K|RAPGEF4_uc010zec.1_Missense_Mutation_p.E287K|RAPGEF4_uc010zed.1_Missense_Mutation_p.E269K|RAPGEF4_uc010zee.1_Missense_Mutation_p.E287K|RAPGEF4_uc010fqo.2_Missense_Mutation_p.E269K|RAPGEF4_uc010zef.1_Missense_Mutation_p.E220K|RAPGEF4_uc010zeg.1_Missense_Mutation_p.E267K|RAPGEF4_uc010fqp.1_Missense_Mutation_p.E220K|RAPGEF4_uc010zeh.1_Missense_Mutation_p.E220K	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	440	cAMP 2.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CGTCTTACGAGAAGATAACTG	0.483													17	77	---	---	---	---	PASS
NFE2L2	4780	broad.mit.edu	37	2	178098804	178098804	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:178098804C>T	uc002ulh.3	-	2	796	c.241G>A	c.(241-243)GGT>AGT	p.G81S	NFE2L2_uc002ulg.3_Missense_Mutation_p.G65S|NFE2L2_uc010zfa.1_Missense_Mutation_p.G65S|NFE2L2_uc002uli.3_Missense_Mutation_p.G65S|NFE2L2_uc010fra.2_Missense_Mutation_p.G65S|NFE2L2_uc010frb.2_Missense_Mutation_p.G65S	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	81					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			AGAAATTCACCTGTCTCTTCA	0.438			Mis		NSCLC|HNSCC					HNSCC(56;0.16)			23	79	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179427766	179427766	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:179427766G>A	uc010zfg.1	-	275	75613	c.75389C>T	c.(75388-75390)ACT>ATT	p.T25130I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T18825I|TTN_uc010zfi.1_Missense_Mutation_p.T18758I|TTN_uc010zfj.1_Missense_Mutation_p.T18633I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	26057							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTTGATAGTGACAAATAA	0.468													7	237	---	---	---	---	PASS
ASNSD1	54529	broad.mit.edu	37	2	190535246	190535246	+	Nonsense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:190535246C>T	uc002uqt.2	+	6	2160	c.1726C>T	c.(1726-1728)CGA>TGA	p.R576*		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	576	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			GACTTTACCCCGAGGAATTGG	0.413													19	88	---	---	---	---	PASS
WDFY1	57590	broad.mit.edu	37	2	224759044	224759044	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:224759044C>G	uc002vnq.2	-	8	789	c.738G>C	c.(736-738)CAG>CAC	p.Q246H		NM_020830	NP_065881	Q8IWB7	WDFY1_HUMAN	WD repeat and FYVE domain containing 1	246	WD 6.					cytosol|early endosome|nucleus	1-phosphatidylinositol binding|zinc ion binding			lung(1)	1		all_lung(227;0.00682)|Lung NSC(271;0.00859)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;5.34e-10)|all cancers(144;1.67e-07)|Lung(261;0.00807)|LUSC - Lung squamous cell carcinoma(224;0.00843)		AGCACAGCGACTGCACCTTGT	0.502													5	47	---	---	---	---	PASS
NR1D2	9975	broad.mit.edu	37	3	24001171	24001171	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:24001171C>G	uc003ccs.2	+	4	701	c.382C>G	c.(382-384)CGG>GGG	p.R128G	NR1D2_uc010hfd.2_RNA|NR1D2_uc011awk.1_Missense_Mutation_p.R53G	NM_005126	NP_005117	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	128	Nuclear receptor.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			urinary_tract(1)|kidney(1)|skin(1)	3						GGGTTTCTTTCGGAGAAGTAT	0.353													5	73	---	---	---	---	PASS
EPM2AIP1	9852	broad.mit.edu	37	3	37033875	37033875	+	Nonsense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:37033875G>A	uc003cgk.2	-	1	921	c.694C>T	c.(694-696)CAG>TAG	p.Q232*	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	232						endoplasmic reticulum					0						CCTGCTGTCTGCAGGGACTCT	0.498													5	195	---	---	---	---	PASS
CADPS	8618	broad.mit.edu	37	3	62570895	62570895	+	Silent	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:62570895G>T	uc003dll.2	-	8	1902	c.1542C>A	c.(1540-1542)GTC>GTA	p.V514V	CADPS_uc003dlk.1_Silent_p.V18V|CADPS_uc003dlm.2_Silent_p.V514V|CADPS_uc003dln.2_Silent_p.V514V	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	514					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TATCCATTCGGACAGCAAGTT	0.448													23	107	---	---	---	---	PASS
CADPS	8618	broad.mit.edu	37	3	62570972	62570972	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:62570972G>T	uc003dll.2	-	8	1825	c.1465C>A	c.(1465-1467)CCC>ACC	p.P489T	CADPS_uc003dlk.1_5'UTR|CADPS_uc003dlm.2_Missense_Mutation_p.P489T|CADPS_uc003dln.2_Missense_Mutation_p.P489T	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	489					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GACTGTTTGGGGCTGTTCGGG	0.398													25	104	---	---	---	---	PASS
TMF1	7110	broad.mit.edu	37	3	69097101	69097101	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:69097101C>A	uc003dnn.2	-	2	1002	c.755G>T	c.(754-756)GGT>GTT	p.G252V	TMF1_uc011bfx.1_Missense_Mutation_p.G252V	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	252					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		GGTAGAAGTACCTGATGAAAA	0.403													14	75	---	---	---	---	PASS
OR5H2	79310	broad.mit.edu	37	3	98002546	98002546	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:98002546C>T	uc003dsj.1	+	1	815	c.815C>T	c.(814-816)GCA>GTA	p.A272V		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						TCTCCACAAGCAGATGACCAA	0.378													11	79	---	---	---	---	PASS
CLDND1	56650	broad.mit.edu	37	3	98235705	98235705	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:98235705G>A	uc003dsp.2	-	5	1440	c.560C>T	c.(559-561)TCA>TTA	p.S187L	CLDND1_uc003dso.2_Intron|CLDND1_uc003dsq.2_Missense_Mutation_p.S187L|CLDND1_uc003dss.2_Missense_Mutation_p.S187L|CLDND1_uc003dsr.2_Missense_Mutation_p.S92L|CLDND1_uc003dst.2_Missense_Mutation_p.S210L|CLDND1_uc003dsu.2_Missense_Mutation_p.S187L|CLDND1_uc003dsv.2_Missense_Mutation_p.S187L	NM_019895	NP_063948	Q9NY35	CLDN1_HUMAN	claudin domain containing 1 protein isoform a	187	Helical; (Potential).					integral to membrane				ovary(1)	1						ACAACTTACTGAGCCCAGTGT	0.443													14	68	---	---	---	---	PASS
COL8A1	1295	broad.mit.edu	37	3	99509692	99509692	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:99509692C>A	uc003dtg.1	+	4	411	c.166C>A	c.(166-168)CAG>AAG	p.Q56K	COL8A1_uc003dth.1_Missense_Mutation_p.Q56K|COL8A1_uc003dti.1_Missense_Mutation_p.Q56K	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	56	Nonhelical region (NC2).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						GCCCCTGGGTCAGCAAGTACC	0.537													7	81	---	---	---	---	PASS
ZIC1	7545	broad.mit.edu	37	3	147128288	147128288	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:147128288G>C	uc003ewe.2	+	1	1108	c.389G>C	c.(388-390)GGC>GCC	p.G130A		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	130					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GGCTTCGGGGGCCCACACGGC	0.711													4	32	---	---	---	---	PASS
MFSD1	64747	broad.mit.edu	37	3	158539385	158539385	+	Splice_Site	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:158539385G>C	uc003fcl.1	+	10	894	c.864_splice	c.e10-1	p.K288_splice	MFSD1_uc003fcm.1_Splice_Site|MFSD1_uc003fcn.1_Splice_Site_p.K191_splice|MFSD1_uc011bow.1_Splice_Site_p.K249_splice|MFSD1_uc011box.1_Splice_Site_p.K215_splice	NM_022736	NP_073573	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing						transmembrane transport	integral to membrane					0			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TTTAATTTTAGAGTTTTCTTT	0.284													3	114	---	---	---	---	PASS
TTC14	151613	broad.mit.edu	37	3	180328168	180328168	+	Silent	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:180328168T>C	uc003fkk.2	+	12	2283	c.2151T>C	c.(2149-2151)AAT>AAC	p.N717N	TTC14_uc003fkl.2_3'UTR|TTC14_uc003fkm.2_Intron	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	717							RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			GAGAGGACAATTATGGGGAGG	0.358													8	147	---	---	---	---	PASS
HTR3E	285242	broad.mit.edu	37	3	183824055	183824055	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr3:183824055C>G	uc010hxq.2	+	8	1531	c.1065C>G	c.(1063-1065)AAC>AAG	p.N355K	HTR3E_uc003fml.3_Missense_Mutation_p.N340K|HTR3E_uc003fmm.2_Missense_Mutation_p.N370K|HTR3E_uc010hxr.2_Missense_Mutation_p.N381K|HTR3E_uc003fmn.2_Missense_Mutation_p.N355K	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	355	Cytoplasmic (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TCCACTGCAACAGCCCGGGGA	0.637													6	70	---	---	---	---	PASS
STK32B	55351	broad.mit.edu	37	4	5170131	5170131	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr4:5170131C>T	uc003gih.1	+	3	278	c.214C>T	c.(214-216)CTG>TTG	p.L72L	STK32B_uc010ida.1_Silent_p.L25L	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	72	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						TTTCCGGGAGCTGCAGATCAT	0.532													3	40	---	---	---	---	PASS
NFXL1	152518	broad.mit.edu	37	4	47905311	47905311	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr4:47905311T>C	uc010igh.2	-	5	723	c.546A>G	c.(544-546)ATA>ATG	p.I182M	NFXL1_uc003gxp.2_Missense_Mutation_p.I182M|NFXL1_uc003gxq.3_RNA|NFXL1_uc010igi.2_Missense_Mutation_p.I182M	NM_152995	NP_694540	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like	182	RING-type; atypical.					integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GCATGTGAAATATACAGAAAC	0.343													12	54	---	---	---	---	PASS
C4orf51	646603	broad.mit.edu	37	4	146651106	146651106	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr4:146651106G>T	uc003ikk.2	+	5	490	c.490G>T	c.(490-492)GTC>TTC	p.V164F		NM_001080531	NP_001074000	C9J302	CD051_HUMAN	chromosome 4 open reading frame 51	164											0						AGGGAAAGGTGTCCTAAAGCA	0.498													12	62	---	---	---	---	PASS
CDH10	1008	broad.mit.edu	37	5	24498560	24498560	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:24498560G>T	uc003jgr.1	-	9	1794	c.1462C>A	c.(1462-1464)CAG>AAG	p.Q488K	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	488	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ACAGCAAACTGTGGGGCATTG	0.408										HNSCC(23;0.051)			14	83	---	---	---	---	PASS
PLCXD3	345557	broad.mit.edu	37	5	41382481	41382481	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:41382481G>T	uc003jmm.1	-	2	361	c.259C>A	c.(259-261)CAG>AAG	p.Q87K		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	87	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						GCTCCTAGCTGGCCAGTAAAA	0.448													12	78	---	---	---	---	PASS
MRPS30	10884	broad.mit.edu	37	5	44815184	44815184	+	Silent	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:44815184T>C	uc003joh.2	+	5	1238	c.1200T>C	c.(1198-1200)CCT>CCC	p.P400P		NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	400					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					AAAGTAAGCCTCTTTATGAAA	0.333													8	58	---	---	---	---	PASS
MAST4	375449	broad.mit.edu	37	5	66429345	66429345	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:66429345G>T	uc003jut.1	+	16	1598	c.1530G>T	c.(1528-1530)TTG>TTT	p.L510F	MAST4_uc003juu.1_Missense_Mutation_p.L520F|MAST4_uc011cra.1_Missense_Mutation_p.L493F|MAST4_uc003juv.2_Missense_Mutation_p.L505F|MAST4_uc003juw.2_Missense_Mutation_p.L505F	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	702	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CTCATAGCTTGTTGGTTACCT	0.408													6	150	---	---	---	---	PASS
AP3B1	8546	broad.mit.edu	37	5	77521374	77521374	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:77521374T>C	uc003kfj.2	-	6	720	c.595A>G	c.(595-597)AAA>GAA	p.K199E		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	199					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		ACTGTGCTTTTATCTTTCAGA	0.229									Hermansky-Pudlak_syndrome				5	30	---	---	---	---	PASS
LOC153328	153328	broad.mit.edu	37	5	135188282	135188282	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:135188282C>A	uc003laz.1	+	4	365	c.193C>A	c.(193-195)CCC>ACC	p.P65T	LOC153328_uc003lba.2_Missense_Mutation_p.P65T			Q6ZT89	S2548_HUMAN	RecName: Full=Putative mitochondrial carrier protein FLJ44862;	65	Solcar 1.|Helical; Name=2; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CATGTCCTTCCCCCTCGCCAG	0.627													5	162	---	---	---	---	PASS
PKD2L2	27039	broad.mit.edu	37	5	137241999	137241999	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:137241999C>T	uc003lby.2	+	6	907	c.851C>T	c.(850-852)TCC>TTC	p.S284F	PKD2L2_uc010jep.1_Missense_Mutation_p.S224F|PKD2L2_uc003lbw.1_Missense_Mutation_p.S284F|PKD2L2_uc003lbx.2_Missense_Mutation_p.S284F|PKD2L2_uc011cyi.1_5'UTR	NM_014386	NP_055201	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	284	Helical; (Potential).					integral to membrane	calcium ion binding|ion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTTATTGCTTCCTGTGAAATC	0.343													18	96	---	---	---	---	PASS
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139876442	139876442	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:139876442A>T	uc003lfs.1	+	15	2707	c.2583A>T	c.(2581-2583)AAA>AAT	p.K861N	ANKHD1_uc003lfq.1_Missense_Mutation_p.K880N|ANKHD1_uc003lfr.2_Missense_Mutation_p.K861N|ANKHD1_uc003lft.1_Intron|ANKHD1_uc003lfu.1_Missense_Mutation_p.K341N|ANKHD1_uc003lfv.1_Intron	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	861						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAAACCAAAGGTCAGAAAG	0.433													16	109	---	---	---	---	PASS
PCDHB2	56133	broad.mit.edu	37	5	140475898	140475898	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:140475898C>G	uc003lil.2	+	1	1662	c.1524C>G	c.(1522-1524)ATC>ATG	p.I508M	PCDHB2_uc003lim.1_Missense_Mutation_p.I169M	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	508	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTCTCCATCAACGCGGACA	0.701													24	142	---	---	---	---	PASS
ARAP3	64411	broad.mit.edu	37	5	141039405	141039405	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:141039405C>T	uc003llm.2	-	22	3286	c.3208G>A	c.(3208-3210)GGG>AGG	p.G1070R	ARAP3_uc003lll.2_Missense_Mutation_p.G21R|ARAP3_uc011dbe.1_Missense_Mutation_p.G732R|ARAP3_uc003lln.2_Missense_Mutation_p.G901R	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1070	Rho-GAP.				cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						TCGTGCTCCCCTCGCCCATCC	0.567													4	35	---	---	---	---	PASS
ITK	3702	broad.mit.edu	37	5	156638380	156638380	+	Splice_Site	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:156638380G>T	uc003lwo.1	+	3	407	c.325_splice	c.e3+1	p.E109_splice		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase						cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTTAAAGAAGGTAATTAAACT	0.493			T	SYK	peripheral T-cell lymphoma								18	98	---	---	---	---	PASS
PROP1	5626	broad.mit.edu	37	5	177422872	177422872	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr5:177422872C>T	uc003mif.1	-	1	372	c.63G>A	c.(61-63)CTG>CTA	p.L21L		NM_006261	NP_006252	O75360	PROP1_HUMAN	PROP paired-like homeobox 1	21					central nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTCAGGCAACAGGTTGCTGC	0.657													9	77	---	---	---	---	PASS
HIST1H2AH	85235	broad.mit.edu	37	6	27115231	27115231	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr6:27115231C>T	uc003niz.2	+	1	324	c.324C>T	c.(322-324)GTC>GTT	p.V108V	HIST1H2BK_uc003nix.1_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080596	NP_542163	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	108					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGGGTGGTGTCTTGCCCAATA	0.547													4	98	---	---	---	---	PASS
PRIM2	5558	broad.mit.edu	37	6	57512544	57512544	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr6:57512544G>C	uc003pdx.2	+	15	1459	c.1372G>C	c.(1372-1374)GGT>CGT	p.G458R		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	458					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TCTAAATGGTGGTAAAGACAT	0.388													5	222	---	---	---	---	PASS
EYS	346007	broad.mit.edu	37	6	66200499	66200499	+	Nonsense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr6:66200499C>A	uc011dxu.1	-	5	1388	c.850G>T	c.(850-852)GAG>TAG	p.E284*	EYS_uc003peq.2_Nonsense_Mutation_p.E284*|EYS_uc003per.1_Nonsense_Mutation_p.E284*|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	284	EGF-like 3.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						GAAAATTGCTCATCACATTCA	0.289													35	31	---	---	---	---	PASS
COL12A1	1303	broad.mit.edu	37	6	75828897	75828897	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr6:75828897C>T	uc003phs.2	-	46	7382	c.7216G>A	c.(7216-7218)GCC>ACC	p.A2406T	COL12A1_uc003pht.2_Missense_Mutation_p.A1242T	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2406	VWFA 4.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						AACGTGAGGGCCTTGCCTACA	0.473													5	60	---	---	---	---	PASS
MDN1	23195	broad.mit.edu	37	6	90353767	90353767	+	Missense_Mutation	SNP	A	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr6:90353767A>C	uc003pnn.1	-	102	16864	c.16748T>G	c.(16747-16749)CTC>CGC	p.L5583R		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5583	VWFA.				protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CCACTGTCTGAGGGCATCGCT	0.463													3	108	---	---	---	---	PASS
BEND3	57673	broad.mit.edu	37	6	107391975	107391975	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr6:107391975C>G	uc003prs.2	-	5	1070	c.420G>C	c.(418-420)GAG>GAC	p.E140D		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	140										ovary(3)	3						GATTCTTCTTCTCCATGATCT	0.577													16	132	---	---	---	---	PASS
MCM9	254394	broad.mit.edu	37	6	119232904	119232904	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr6:119232904G>C	uc003pyh.2	-	7	1324	c.1061C>G	c.(1060-1062)CCT>CGT	p.P354R		NM_153255	NP_694987	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	354	MCM.|ATP (Potential).				DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			ovary(1)	1		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		CCCTGTGCCAGGATCCCCAAC	0.378													13	51	---	---	---	---	PASS
HIVEP2	3097	broad.mit.edu	37	6	143092297	143092297	+	Silent	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr6:143092297T>C	uc003qjd.2	-	5	4322	c.3579A>G	c.(3577-3579)CAA>CAG	p.Q1193Q		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1193					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GAATTGTCTCTTGATGTGGAA	0.433													5	210	---	---	---	---	PASS
SYNE1	23345	broad.mit.edu	37	6	152671350	152671350	+	Nonsense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr6:152671350C>A	uc010kiw.2	-	72	12456	c.11854G>T	c.(11854-11856)GAG>TAG	p.E3952*	SYNE1_uc003qot.3_Intron|SYNE1_uc003qou.3_Nonsense_Mutation_p.E3952*|SYNE1_uc010kja.1_Nonsense_Mutation_p.E657*	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3952	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGCTTGTCTCCAGGAGGTCA	0.522										HNSCC(10;0.0054)			28	79	---	---	---	---	PASS
EIF3B	8662	broad.mit.edu	37	7	2402714	2402714	+	Silent	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:2402714G>T	uc003slx.2	+	4	905	c.822G>T	c.(820-822)ACG>ACT	p.T274T	EIF3B_uc003sly.2_Silent_p.T274T|EIF3B_uc003slz.1_Silent_p.T235T|EIF3B_uc003sma.2_Silent_p.T2T	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	274	Sufficient for interaction with EIF3E.|Sufficient for interaction with EIF3J.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		GGTATATGACGATCAGTGACG	0.502													23	293	---	---	---	---	PASS
CARD11	84433	broad.mit.edu	37	7	2956965	2956965	+	Missense_Mutation	SNP	G	A	A	rs142828146		TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:2956965G>A	uc003smv.2	-	20	3066	c.2662C>T	c.(2662-2664)CGT>TGT	p.R888C		NM_032415	NP_115791	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	888					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity	p.R881C(1)		haematopoietic_and_lymphoid_tissue(43)|ovary(2)|kidney(2)|skin(2)|central_nervous_system(1)	50		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CGCGAGAGACGGGGGCTGACC	0.557			Mis		DLBCL								13	90	---	---	---	---	PASS
SDK1	221935	broad.mit.edu	37	7	4247876	4247876	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:4247876G>T	uc003smx.2	+	37	5499	c.5360G>T	c.(5359-5361)GGA>GTA	p.G1787V	SDK1_uc010kso.2_Missense_Mutation_p.G1043V|SDK1_uc003smy.2_Missense_Mutation_p.G274V	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1787	Fibronectin type-III 11.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GCCGGAGATGGACCTAAGAGT	0.617													4	60	---	---	---	---	PASS
SNX13	23161	broad.mit.edu	37	7	17874389	17874389	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:17874389T>C	uc003stw.1	-	14	1672	c.1459A>G	c.(1459-1461)AGA>GGA	p.R487G	SNX13_uc003stv.2_Missense_Mutation_p.R487G|SNX13_uc010kuc.2_Missense_Mutation_p.R284G			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	487	RGS.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					AATACCTTTCTTTGAATGTCA	0.279													5	46	---	---	---	---	PASS
CCDC129	223075	broad.mit.edu	37	7	31690783	31690783	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:31690783A>G	uc003tcj.1	+	12	3604	c.2611A>G	c.(2611-2613)AAG>GAG	p.K871E	CCDC129_uc011kad.1_Missense_Mutation_p.K881E|CCDC129_uc003tci.1_Missense_Mutation_p.K722E|CCDC129_uc011kae.1_Missense_Mutation_p.K897E|CCDC129_uc003tck.1_Missense_Mutation_p.K779E	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	871											0						GGAAGCCATGAAGACGATATG	0.478													3	130	---	---	---	---	PASS
ELMO1	9844	broad.mit.edu	37	7	37264597	37264597	+	Silent	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:37264597C>A	uc003tfk.1	-	9	895	c.588G>T	c.(586-588)TCG>TCT	p.S196S	ELMO1_uc011kbc.1_Silent_p.S100S|ELMO1_uc010kxg.1_Silent_p.S196S	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	196					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GCTGCAGGATCGAGATGTCTA	0.502													12	67	---	---	---	---	PASS
AEBP1	165	broad.mit.edu	37	7	44150570	44150570	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:44150570T>A	uc003tkb.2	+	13	1849	c.1544T>A	c.(1543-1545)GTG>GAG	p.V515E	AEBP1_uc003tkc.3_Missense_Mutation_p.V58E|AEBP1_uc003tkd.2_5'Flank	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	515	Required for DNA-binding and interaction with NFKBIA (By similarity).|F5/8 type C.|Interaction with MAPK1 and MAPK3 (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CCAGAGCCGGTGGTGGCTCGT	0.632													11	69	---	---	---	---	PASS
ABCA13	154664	broad.mit.edu	37	7	48313943	48313943	+	Silent	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:48313943T>C	uc003toq.2	+	17	4705	c.4680T>C	c.(4678-4680)GGT>GGC	p.G1560G	ABCA13_uc010kyr.2_Silent_p.G1063G	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1560					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTGTAAAAGGTATTTACTTTA	0.313													17	117	---	---	---	---	PASS
CRCP	27297	broad.mit.edu	37	7	65617275	65617275	+	Silent	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:65617275A>G	uc003tus.2	+	6	523	c.378A>G	c.(376-378)GCA>GCG	p.A126A	CRCP_uc003tuv.2_RNA|CRCP_uc011kdw.1_Silent_p.A119A|CRCP_uc003tut.2_Silent_p.A93A|CRCP_uc003tuu.2_Silent_p.A49A	NM_014478	NP_055293	O75575	RPC9_HUMAN	calcitonin gene-related peptide-receptor	126					acrosome reaction|innate immune response|response to virus|transcription from RNA polymerase III promoter	DNA polymerase III complex|nucleus|plasma membrane	calcitonin receptor activity|DNA-directed RNA polymerase activity|nucleotide binding				0						TTCTGCCTGCAGAGCCAGAGG	0.527													10	39	---	---	---	---	PASS
TYW1	55253	broad.mit.edu	37	7	66463151	66463151	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:66463151G>T	uc003tvn.2	+	2	253	c.104G>T	c.(103-105)TGG>TTG	p.W35L	SBDS_uc003tvm.1_5'Flank|TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	35					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				ATTAGCCTTTGGATTTGTGTC	0.348													17	159	---	---	---	---	PASS
TYW1	55253	broad.mit.edu	37	7	66463152	66463152	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:66463152G>T	uc003tvn.2	+	2	254	c.105G>T	c.(103-105)TGG>TGT	p.W35C	SBDS_uc003tvm.1_5'Flank|TYW1_uc010lai.2_RNA	NM_018264	NP_060734	Q9NV66	TYW1_HUMAN	radical S-adenosyl methionine and flavodoxin	35					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			skin(1)	1		Lung NSC(55;0.0846)|all_lung(88;0.183)				TTAGCCTTTGGATTTGTGTCC	0.343													18	160	---	---	---	---	PASS
CACNA2D1	781	broad.mit.edu	37	7	81589146	81589146	+	Splice_Site	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:81589146C>A	uc003uhr.1	-	37	3223	c.2967_splice	c.e37-1	p.R989_splice	CACNA2D1_uc011kgy.1_Splice_Site_p.R201_splice	NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha							voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ATGAAAGATTCTGCAAAATAA	0.313													8	31	---	---	---	---	PASS
MCM7	4176	broad.mit.edu	37	7	99694927	99694927	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:99694927G>A	uc003usw.1	-	10	1708	c.1198C>T	c.(1198-1200)CGC>TGC	p.R400C	MCM7_uc003usv.1_Missense_Mutation_p.R224C|MCM7_uc003usx.1_Missense_Mutation_p.R224C	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	400	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	TACTTACTGCGAGGCGCCAGT	0.473													5	45	---	---	---	---	PASS
MUC17	140453	broad.mit.edu	37	7	100682143	100682143	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:100682143C>T	uc003uxp.1	+	3	7499	c.7446C>T	c.(7444-7446)GAC>GAT	p.D2482D	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2482	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|39.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTCCTGTTGACACCAGCACAC	0.517													48	476	---	---	---	---	PASS
RELN	5649	broad.mit.edu	37	7	103113314	103113314	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:103113314T>C	uc003vca.2	-	66	10488	c.10328A>G	c.(10327-10329)CAT>CGT	p.H3443R	RELN_uc010liz.2_Missense_Mutation_p.H3441R	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3443	Arg-rich (basic).				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCTGAGCCCATGTTGTCGTGA	0.383													13	93	---	---	---	---	PASS
C7orf58	79974	broad.mit.edu	37	7	120629925	120629925	+	Splice_Site	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:120629925G>T	uc003vjq.3	+	2	696	c.249_splice	c.e2+1	p.K83_splice	C7orf58_uc003vjr.1_Splice_Site_p.K83_splice|C7orf58_uc003vjs.3_Splice_Site_p.K83_splice	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1							endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AACCAGAAAGGTAAGACTCTC	0.428													5	177	---	---	---	---	PASS
PTPRZ1	5803	broad.mit.edu	37	7	121684484	121684484	+	Nonsense_Mutation	SNP	T	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:121684484T>G	uc003vjy.2	+	23	6341	c.5946T>G	c.(5944-5946)TAT>TAG	p.Y1982*	PTPRZ1_uc003vjz.2_Nonsense_Mutation_p.Y1115*|PTPRZ1_uc011knt.1_Nonsense_Mutation_p.Y572*	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1982	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						AGGAGCAATATGTCTTCATTC	0.388													19	74	---	---	---	---	PASS
GPR37	2861	broad.mit.edu	37	7	124386948	124386948	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:124386948G>A	uc003vli.2	-	2	2124	c.1473C>T	c.(1471-1473)AAC>AAT	p.N491N		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	491	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CTACTGTACAGTTCATCTGAC	0.448													10	108	---	---	---	---	PASS
CTAGE6	340307	broad.mit.edu	37	7	143453398	143453398	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:143453398G>C	uc003wdk.3	-	1	1446	c.1354C>G	c.(1354-1356)CAA>GAA	p.Q452E	uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron|LOC154761_uc003wdj.1_Intron	NM_178561	NP_848656	Q86UF2	CTGE6_HUMAN	CTAGE family, member 6	452	Potential.					integral to membrane					0	Melanoma(164;0.0903)					ACCTGCTTTTGATAAAAATGA	0.413													4	198	---	---	---	---	PASS
OR2A5	393046	broad.mit.edu	37	7	143748079	143748079	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:143748079C>G	uc011ktw.1	+	1	585	c.585C>G	c.(583-585)AAC>AAG	p.N195K		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					CCTGGCTCAACCAGGTGGTCA	0.572													27	238	---	---	---	---	PASS
SSPO	23145	broad.mit.edu	37	7	149500666	149500666	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:149500666C>T	uc010lpk.2	+	55	8067	c.8067C>T	c.(8065-8067)TCC>TCT	p.S2689S		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2689					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CAGGGGTGTCCTTCCTCCTGG	0.682													3	21	---	---	---	---	PASS
MLL3	58508	broad.mit.edu	37	7	152007083	152007083	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr7:152007083C>A	uc003wla.2	-	6	1036	c.817G>T	c.(817-819)GTG>TTG	p.V273L		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	273					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCTTTGTCCACGTTCACTAAC	0.393			N		medulloblastoma								6	81	---	---	---	---	PASS
CSMD1	64478	broad.mit.edu	37	8	3266999	3266999	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr8:3266999C>A	uc011kwk.1	-	13	2083	c.1693G>T	c.(1693-1695)GTT>TTT	p.V565F	CSMD1_uc011kwj.1_5'UTR	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	565	Extracellular (Potential).|Sushi 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAGGTGATAACTCTCTCCCCC	0.552													4	24	---	---	---	---	PASS
SGCZ	137868	broad.mit.edu	37	8	13959960	13959960	+	Silent	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr8:13959960G>T	uc003wwq.2	-	7	1329	c.669C>A	c.(667-669)GTC>GTA	p.V223V	SGCZ_uc010lss.2_Silent_p.V176V	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	210	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CACTCACCTGGACCCCACGGG	0.478													5	44	---	---	---	---	PASS
BIN3	55909	broad.mit.edu	37	8	22481752	22481752	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr8:22481752G>A	uc003xcl.2	-	7	560	c.463C>T	c.(463-465)CTG>TTG	p.L155L	BIN3_uc003xck.2_Silent_p.L107L|BIN3_uc010ltw.2_Silent_p.L101L	NM_018688	NP_061158	Q9NQY0	BIN3_HUMAN	bridging integrator 3	155	BAR.				actin filament organization|barrier septum formation|cell cycle|protein localization|unidimensional cell growth	cytoplasm|cytoskeleton	cytoskeletal adaptor activity				0		Prostate(55;0.0424)|Breast(100;0.102)|all_epithelial(46;0.143)		BRCA - Breast invasive adenocarcinoma(99;0.00664)|Colorectal(74;0.0189)|COAD - Colon adenocarcinoma(73;0.0727)		AGCTTGGCCAGCACTGGCCCC	0.622													3	45	---	---	---	---	PASS
DPYSL2	1808	broad.mit.edu	37	8	26510758	26510758	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr8:26510758T>A	uc003xfb.1	+	13	1822	c.1472T>A	c.(1471-1473)CTG>CAG	p.L491Q	DPYSL2_uc003xfa.2_Missense_Mutation_p.L596Q|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Missense_Mutation_p.L455Q	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	491					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		CTGGCTGAGCTGAGAGGGGTT	0.602													16	176	---	---	---	---	PASS
TRIM55	84675	broad.mit.edu	37	8	67047300	67047300	+	Silent	SNP	C	T	T	rs150385092	by1000genomes	TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr8:67047300C>T	uc003xvv.2	+	3	643	c.417C>T	c.(415-417)TGC>TGT	p.C139C	TRIM55_uc003xvu.2_Silent_p.C139C|TRIM55_uc003xvw.2_Silent_p.C139C|TRIM55_uc003xvx.2_Silent_p.C139C	NM_184085	NP_908973	Q9BYV6	TRI55_HUMAN	tripartite motif-containing 55 isoform 1	139	B box-type.					cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GTCTGAACTGCGAAGTACCCA	0.527													4	109	---	---	---	---	PASS
ZFHX4	79776	broad.mit.edu	37	8	77767552	77767552	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr8:77767552G>T	uc003yav.2	+	10	8647	c.8260G>T	c.(8260-8262)GAT>TAT	p.D2754Y	ZFHX4_uc003yau.1_Missense_Mutation_p.D2799Y|ZFHX4_uc003yaw.1_Missense_Mutation_p.D2754Y	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2754						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAATAAAACCGATTTTGATGA	0.443										HNSCC(33;0.089)			6	50	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113326816	113326816	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr8:113326816T>A	uc003ynu.2	-	48	7550	c.7391A>T	c.(7390-7392)GAT>GTT	p.D2464V	CSMD3_uc003yns.2_Missense_Mutation_p.D1666V|CSMD3_uc003ynt.2_Missense_Mutation_p.D2424V|CSMD3_uc011lhx.1_Missense_Mutation_p.D2360V|CSMD3_uc003ynw.1_Missense_Mutation_p.D175V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2464	CUB 14.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCCAGTAGAATCTAGCCGTAA	0.388										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	49	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113702181	113702181	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr8:113702181G>T	uc003ynu.2	-	14	2230	c.2071C>A	c.(2071-2073)CAG>AAG	p.Q691K	CSMD3_uc003yns.2_5'UTR|CSMD3_uc003ynt.2_Missense_Mutation_p.Q651K|CSMD3_uc011lhx.1_Missense_Mutation_p.Q587K	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	691	Extracellular (Potential).|Sushi 3.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AACCCAAACTGGCATTCAAAC	0.373										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	257	---	---	---	---	PASS
FAM135B	51059	broad.mit.edu	37	8	139164043	139164043	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr8:139164043C>A	uc003yuy.2	-	13	2846	c.2675G>T	c.(2674-2676)AGG>ATG	p.R892M	FAM135B_uc003yux.2_Missense_Mutation_p.R793M|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.R454M|FAM135B_uc003yvb.2_Missense_Mutation_p.R454M	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	892								p.R892G(1)		ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AGATCTGGTCCTGGGGTTTTC	0.473										HNSCC(54;0.14)			11	159	---	---	---	---	PASS
GDA	9615	broad.mit.edu	37	9	74838057	74838057	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr9:74838057G>A	uc004aiq.2	+	7	811	c.628G>A	c.(628-630)GTG>ATG	p.V210M	GDA_uc011lse.1_Missense_Mutation_p.V136M|GDA_uc011lsf.1_Missense_Mutation_p.V136M|GDA_uc004air.2_Missense_Mutation_p.V210M|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Intron|GDA_uc004ait.1_Missense_Mutation_p.V136M	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	210					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		GAAGCCCATAGTGACACCACG	0.308													36	136	---	---	---	---	PASS
C9orf170	401535	broad.mit.edu	37	9	89771592	89771592	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr9:89771592C>G	uc004apa.1	+	2	360	c.273C>G	c.(271-273)AAC>AAG	p.N91K		NM_001001709	NP_001001709	A2RU37	CI170_HUMAN	hypothetical protein LOC401535	91											0						attggaaaaacctCTTGATAG	0.184													6	32	---	---	---	---	PASS
CTSL2	1515	broad.mit.edu	37	9	99797855	99797855	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr9:99797855C>T	uc004awt.2	-	6	939	c.742G>A	c.(742-744)GTT>ATT	p.V248I	CTSL2_uc010msi.2_Missense_Mutation_p.V248I|CTSL2_uc004awu.2_Missense_Mutation_p.V193I|CTSL2_uc010msj.1_Missense_Mutation_p.V193I	NM_001333	NP_001324	O60911	CATL2_HUMAN	cathepsin L2 preproprotein	248						lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(62;0.0559)				TCCATAGCAACGGAGATGGGC	0.468													10	51	---	---	---	---	PASS
ZBTB34	403341	broad.mit.edu	37	9	129642902	129642902	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr9:129642902C>T	uc004bqm.3	+	2	1309	c.1212C>T	c.(1210-1212)TTC>TTT	p.F404F		NM_001099270	NP_001092740	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	404	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGTGCAAGTTCTGTGGGAAGA	0.493													9	34	---	---	---	---	PASS
SPTAN1	6709	broad.mit.edu	37	9	131339714	131339714	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr9:131339714A>T	uc004bvl.3	+	8	1127	c.1014A>T	c.(1012-1014)GAA>GAT	p.E338D	SPTAN1_uc011mbg.1_Missense_Mutation_p.E338D|SPTAN1_uc011mbh.1_Missense_Mutation_p.E350D|SPTAN1_uc004bvm.3_Missense_Mutation_p.E338D|SPTAN1_uc004bvn.3_Missense_Mutation_p.E338D	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	338	Spectrin 4.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						AGCGAGAGGAACTGATTACAA	0.517													25	96	---	---	---	---	PASS
DIP2C	22982	broad.mit.edu	37	10	468780	468780	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr10:468780C>A	uc001ifp.2	-	5	678	c.588G>T	c.(586-588)ATG>ATT	p.M196I	DIP2C_uc009xhk.1_Missense_Mutation_p.W198L	NM_014974	NP_055789	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C	196						nucleus	catalytic activity|transcription factor binding			breast(4)|ovary(2)|large_intestine(1)	7		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GGGTCTGAGCCATGACGTCCG	0.612													13	68	---	---	---	---	PASS
ITGA8	8516	broad.mit.edu	37	10	15600082	15600082	+	Silent	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr10:15600082T>C	uc001ioc.1	-	26	2757	c.2757A>G	c.(2755-2757)GCA>GCG	p.A919A	ITGA8_uc010qcb.1_Silent_p.A904A	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	919	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						CCAGTATTTTTGCAGGGCTCT	0.448													7	160	---	---	---	---	PASS
ANKRD26	22852	broad.mit.edu	37	10	27306536	27306536	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr10:27306536C>G	uc001ith.2	-	30	4570	c.4398G>C	c.(4396-4398)AGG>AGC	p.R1466S	ANKRD26_uc001itg.2_Missense_Mutation_p.R1153S|ANKRD26_uc009xku.1_Missense_Mutation_p.R1467S	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1466	Potential.					centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						CTACCATATTCCTTTCTATAT	0.308													5	79	---	---	---	---	PASS
ANKRD26	22852	broad.mit.edu	37	10	27366456	27366456	+	Silent	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr10:27366456A>G	uc001ith.2	-	9	1060	c.888T>C	c.(886-888)TAT>TAC	p.Y296Y	ANKRD26_uc001itg.2_Silent_p.Y15Y|ANKRD26_uc009xku.1_Silent_p.Y296Y	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	296						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TCACAGTGCCATATGTTGCTT	0.323													6	81	---	---	---	---	PASS
RBP4	5950	broad.mit.edu	37	10	95351849	95351849	+	Nonsense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr10:95351849C>A	uc001kit.2	-	6	673	c.589G>T	c.(589-591)GAA>TAA	p.E197*		NM_006744	NP_006735	P02753	RET4_HUMAN	retinol-binding protein 4, plasma precursor	197					cardiac muscle tissue development|embryonic organ morphogenesis|embryonic retina morphogenesis in camera-type eye|embryonic skeletal system development|female genitalia morphogenesis|gluconeogenesis|glucose homeostasis|heart trabecula formation|lung development|maintenance of gastrointestinal epithelium|negative regulation of cardiac muscle cell proliferation|positive regulation of immunoglobulin secretion|positive regulation of insulin secretion|response to retinoic acid|retinol metabolic process|urinary bladder development|uterus development|vagina development	extracellular space	protein binding|retinal binding|retinol binding				0		Colorectal(252;0.122)			Vitamin A(DB00162)	AGGTTTCTTTCTGATCTGCCA	0.363													7	56	---	---	---	---	PASS
PDCD11	22984	broad.mit.edu	37	10	105201613	105201613	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr10:105201613C>T	uc001kwy.1	+	31	4675	c.4588C>T	c.(4588-4590)CGG>TGG	p.R1530W		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1530					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		AGAAGCGCCCCGGCTGCAGCT	0.607													3	53	---	---	---	---	PASS
MUC5B	727897	broad.mit.edu	37	11	1281021	1281021	+	Nonsense_Mutation	SNP	T	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:1281021T>A	uc009ycr.1	+	67	17886	c.17760T>A	c.(17758-17760)TGT>TGA	p.C5920*	MUC5B_uc001ltb.2_Nonsense_Mutation_p.C5586*	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5583	VWFC 3.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGCAGTGCTGTGGGGAGTGCG	0.667													21	75	---	---	---	---	PASS
ANO3	63982	broad.mit.edu	37	11	26556100	26556100	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:26556100T>C	uc001mqt.3	+	9	1112	c.967T>C	c.(967-969)TCA>CCA	p.S323P	ANO3_uc010rdr.1_Missense_Mutation_p.S307P|ANO3_uc010rds.1_Missense_Mutation_p.S162P|ANO3_uc010rdt.1_Missense_Mutation_p.S177P	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	323	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AAATGGAATATCAAAAGTGGG	0.323													15	81	---	---	---	---	PASS
NUP160	23279	broad.mit.edu	37	11	47808037	47808037	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:47808037C>A	uc001ngm.2	-	32	3901	c.3816G>T	c.(3814-3816)CAG>CAT	p.Q1272H	NUP160_uc009ylw.2_RNA	NM_015231	NP_056046	Q12769	NU160_HUMAN	nucleoporin 160kDa	1272					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7						CAGATGAGAGCTGATTGGCTG	0.463													4	136	---	---	---	---	PASS
OR4P4	81300	broad.mit.edu	37	11	55405936	55405936	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:55405936G>T	uc010rij.1	+	1	103	c.103G>T	c.(103-105)GCT>TCT	p.A35S		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TTGCTACATTGCTATTTGGAT	0.368													4	105	---	---	---	---	PASS
OR4P4	81300	broad.mit.edu	37	11	55406141	55406141	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:55406141A>T	uc010rij.1	+	1	308	c.308A>T	c.(307-309)CAT>CTT	p.H103L		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TTTACCACCCATTTTTTTGGA	0.433													4	80	---	---	---	---	PASS
OR5L1	219437	broad.mit.edu	37	11	55579077	55579077	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:55579077G>C	uc001nhw.1	+	1	135	c.135G>C	c.(133-135)ATG>ATC	p.M45I		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	45	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				ACCTGGGCATGATTGCACTGA	0.488													51	250	---	---	---	---	PASS
OR5D18	219438	broad.mit.edu	37	11	55587917	55587917	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:55587917C>A	uc010rin.1	+	1	812	c.812C>A	c.(811-813)ACA>AAA	p.T271K		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TCCAGGCACACAGTCAAAGTG	0.507													19	96	---	---	---	---	PASS
SERPING1	710	broad.mit.edu	37	11	57379296	57379296	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:57379296T>C	uc001nkp.1	+	7	1327	c.1136T>C	c.(1135-1137)TTC>TCC	p.F379S	SERPING1_uc001nkq.1_Intron|SERPING1_uc010rju.1_Missense_Mutation_p.F327S|SERPING1_uc010rjv.1_Missense_Mutation_p.F384S|SERPING1_uc001nkr.1_Missense_Mutation_p.F379S|SERPING1_uc009ymi.1_Missense_Mutation_p.F388S|SERPING1_uc009ymj.1_Intron|SERPING1_uc001nks.1_Missense_Mutation_p.F70S	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	379					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						CCTTCTGTTTTCAAGGCCATC	0.512									Hereditary_Angioedema				5	159	---	---	---	---	PASS
OR5B12	390191	broad.mit.edu	37	11	58207460	58207460	+	Silent	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:58207460G>T	uc010rkh.1	-	1	165	c.165C>A	c.(163-165)ACC>ACA	p.T55T		NM_001004733	NP_001004733	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B,	55	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AGTACATGGGGGTGTGGAGAC	0.483													10	49	---	---	---	---	PASS
MS4A6E	245802	broad.mit.edu	37	11	60107344	60107344	+	Silent	SNP	T	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:60107344T>A	uc001npd.2	+	3	374	c.360T>A	c.(358-360)ACT>ACA	p.T120T		NM_139249	NP_640342	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member	120	Extracellular (Potential).					integral to membrane	receptor activity				0						TTCAGGGAACTCTGTCTCTGA	0.478													6	265	---	---	---	---	PASS
MS4A12	54860	broad.mit.edu	37	11	60269474	60269474	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:60269474C>A	uc001npr.2	+	4	490	c.433C>A	c.(433-435)CTC>ATC	p.L145I		NM_017716	NP_060186	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member	145	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						CTCTGGCTCTCTCTCTGTGTC	0.393													8	184	---	---	---	---	PASS
PCF11	51585	broad.mit.edu	37	11	82881007	82881007	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:82881007G>T	uc001ozx.3	+	8	3975	c.3630G>T	c.(3628-3630)ATG>ATT	p.M1210I	PCF11_uc010rsu.1_Missense_Mutation_p.M1341I	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	1210					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						CTGCTCCAATGACAGTAGGAA	0.348													4	24	---	---	---	---	PASS
SYTL2	54843	broad.mit.edu	37	11	85445732	85445732	+	Nonsense_Mutation	SNP	T	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:85445732T>A	uc010rth.1	-	6	913	c.637A>T	c.(637-639)AAG>TAG	p.K213*	SYTL2_uc010rtg.1_Nonsense_Mutation_p.K214*|SYTL2_uc010rti.1_Nonsense_Mutation_p.K213*|SYTL2_uc010rtj.1_Nonsense_Mutation_p.K165*|SYTL2_uc001pbf.3_Nonsense_Mutation_p.K213*|SYTL2_uc010rtf.1_Nonsense_Mutation_p.K71*	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	213					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TTCTCTAACTTTTGGATTGAA	0.373													9	89	---	---	---	---	PASS
PRSS23	11098	broad.mit.edu	37	11	86519238	86519238	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:86519238A>G	uc001pcb.2	+	2	769	c.553A>G	c.(553-555)AAA>GAA	p.K185E	PRSS23_uc001pcc.1_Intron|PRSS23_uc010rts.1_Missense_Mutation_p.K153E	NM_007173	NP_009104	O95084	PRS23_HUMAN	protease, serine, 23 precursor	185					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AACCTATGTGAAAGGAACCCA	0.537													6	64	---	---	---	---	PASS
NOX4	50507	broad.mit.edu	37	11	89075240	89075240	+	Splice_Site	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:89075240A>G	uc001pct.2	-	14	1576	c.1337_splice	c.e14+1	p.L446_splice	NOX4_uc009yvr.2_Splice_Site_p.L421_splice|NOX4_uc001pcu.2_Splice_Site_p.L372_splice|NOX4_uc001pcw.2_Splice_Site_p.L139_splice|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Intron|NOX4_uc009yvo.2_Splice_Site|NOX4_uc010rtu.1_Splice_Site_p.L280_splice|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Intron|NOX4_uc009yvq.2_Splice_Site_p.L422_splice	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a						cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				AAAATGACATACAACAGGGTG	0.358													5	59	---	---	---	---	PASS
ATM	472	broad.mit.edu	37	11	108235917	108235917	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:108235917G>T	uc001pkb.1	+	62	9344	c.8959G>T	c.(8959-8961)GAT>TAT	p.D2987Y	ATM_uc009yxr.1_Missense_Mutation_p.D2987Y|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.D1639Y	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2987					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TCTGAATGCAGATGACCAAGA	0.403			D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			7	63	---	---	---	---	PASS
VWA5A	4013	broad.mit.edu	37	11	123993736	123993736	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:123993736A>T	uc001pzu.2	+	8	1039	c.830A>T	c.(829-831)AAT>ATT	p.N277I	VWA5A_uc001pzr.2_Missense_Mutation_p.N277I|VWA5A_uc001pzs.2_Missense_Mutation_p.N277I|VWA5A_uc010sae.1_Missense_Mutation_p.N293I|VWA5A_uc001pzt.2_Missense_Mutation_p.N277I	NM_001130142	NP_001123614	O00534	VMA5A_HUMAN	BCSC-1 isoform 1	277										upper_aerodigestive_tract(1)|ovary(1)	2						CAACCATCAAATACCTGTGGA	0.463													4	72	---	---	---	---	PASS
HEPACAM	220296	broad.mit.edu	37	11	124792701	124792701	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:124792701G>T	uc001qbk.2	-	5	1223	c.817C>A	c.(817-819)CTA>ATA	p.L273I	HEPACAM_uc009zbj.2_5'UTR|HEPACAM_uc001qbl.1_Missense_Mutation_p.L273I	NM_152722	NP_689935	Q14CZ8	HECAM_HUMAN	hepatocyte cell adhesion molecule precursor	273	Cytoplasmic (Potential).				cell adhesion|cell cycle arrest|regulation of growth	cytoplasm|integral to membrane				pancreas(1)	1	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.54e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		TGCTTTTCTAGCTTCTTCTGT	0.483													6	156	---	---	---	---	PASS
ST3GAL4	6484	broad.mit.edu	37	11	126277527	126277527	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:126277527G>C	uc001qds.2	+	6	558	c.339G>C	c.(337-339)CAG>CAC	p.Q113H	ST3GAL4_uc001qdt.2_Missense_Mutation_p.Q109H|ST3GAL4_uc009zcc.2_Intron|ST3GAL4_uc009zcd.2_Missense_Mutation_p.Q102H|ST3GAL4_uc001qdu.2_Missense_Mutation_p.Q109H|ST3GAL4_uc001qdv.2_Missense_Mutation_p.Q113H|ST3GAL4_uc009zce.2_Missense_Mutation_p.Q109H|ST3GAL4_uc001qdw.2_Missense_Mutation_p.Q102H|ST3GAL4_uc001qdx.1_Missense_Mutation_p.Q102H|ST3GAL4_uc001qdy.2_5'UTR|ST3GAL4_uc001qdz.2_5'UTR	NM_006278	NP_006269	Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	113	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		AGAACATCCAGAGGTAAGGCG	0.607													24	151	---	---	---	---	PASS
ARHGAP32	9743	broad.mit.edu	37	11	128844054	128844054	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr11:128844054T>C	uc009zcp.2	-	20	2996	c.2996A>G	c.(2995-2997)CAG>CGG	p.Q999R	ARHGAP32_uc009zcq.1_Missense_Mutation_p.Q959R|ARHGAP32_uc009zco.2_5'UTR|ARHGAP32_uc001qez.2_Missense_Mutation_p.Q650R	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	999					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						AGCCTTACTCTGACTGCTTGA	0.478													9	124	---	---	---	---	PASS
ATN1	1822	broad.mit.edu	37	12	7050104	7050104	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:7050104C>T	uc001qrw.1	+	8	3513	c.3276C>T	c.(3274-3276)ATC>ATT	p.I1092I	ATN1_uc001qrx.1_Silent_p.I1092I|C12orf57_uc009zfj.1_5'Flank	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	1092					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						TTACCCGGATCCCCTACCCAG	0.592													10	74	---	---	---	---	PASS
AICDA	57379	broad.mit.edu	37	12	8757847	8757847	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:8757847G>C	uc001qur.2	-	3	470	c.391C>G	c.(391-393)CGC>GGC	p.R131G	AICDA_uc001qup.1_Missense_Mutation_p.R126G|AICDA_uc001quq.1_Missense_Mutation_p.R126G|AICDA_uc009zgd.1_Intron	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	131					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					ACCCCGGCGCGGTGCAGCCGC	0.642									Immune_Deficiency_with_Hyper-IgM				12	36	---	---	---	---	PASS
GRIN2B	2904	broad.mit.edu	37	12	13761674	13761674	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:13761674C>T	uc001rbt.2	-	9	2052	c.1873G>A	c.(1873-1875)GGG>AGG	p.G625R		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	625	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GAGGTGGTCCCCTTTGGGTTC	0.532													19	91	---	---	---	---	PASS
GRIN2B	2904	broad.mit.edu	37	12	13761675	13761675	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:13761675C>T	uc001rbt.2	-	9	2051	c.1872G>A	c.(1870-1872)AAG>AAA	p.K624K		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	624	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGGTGGTCCCCTTTGGGTTCT	0.532													19	93	---	---	---	---	PASS
SLCO1B3	28234	broad.mit.edu	37	12	21032524	21032524	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:21032524C>T	uc001rek.2	+	10	1416	c.1290C>T	c.(1288-1290)TGC>TGT	p.C430C	SLCO1B3_uc001rel.2_Silent_p.C430C|SLCO1B3_uc010sil.1_Silent_p.C430C|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Silent_p.C255C	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	430	Extracellular (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CTCTAATCTGCGAAAGCAAAT	0.299													4	80	---	---	---	---	PASS
LRRK2	120892	broad.mit.edu	37	12	40704330	40704330	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:40704330A>G	uc001rmg.3	+	31	4536	c.4415A>G	c.(4414-4416)GAA>GGA	p.E1472G	LRRK2_uc009zjw.2_Missense_Mutation_p.E310G|LRRK2_uc001rmi.2_Missense_Mutation_p.E305G	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1472	Roc.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ATCACCAAGGAACTCCTGAAT	0.473													37	201	---	---	---	---	PASS
KRT1	3848	broad.mit.edu	37	12	53074075	53074075	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:53074075C>A	uc001sau.1	-	1	117	c.58G>T	c.(58-60)GGC>TGC	p.G20C	KRT1_uc001sav.1_Missense_Mutation_p.G20C	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	20	Head.|Gly/Phe/Ser-rich.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						CCAGCAGAGCCAGAGCTGAAG	0.512													17	87	---	---	---	---	PASS
ARHGAP9	64333	broad.mit.edu	37	12	57872974	57872974	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:57872974G>A	uc001sod.2	-	5	622	c.429C>T	c.(427-429)ACC>ACT	p.T143T	ARHGAP9_uc001snz.2_5'Flank|ARHGAP9_uc001soa.2_5'Flank|ARHGAP9_uc001sob.2_Silent_p.T72T|ARHGAP9_uc001soc.2_Silent_p.T72T|ARHGAP9_uc001soe.1_Silent_p.T151T|ARHGAP9_uc010sro.1_Silent_p.T72T	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	72	SH3.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			TGGGTCGAGAGGTGGAGGGAG	0.562													4	109	---	---	---	---	PASS
SLC26A10	65012	broad.mit.edu	37	12	58014145	58014145	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:58014145G>A	uc001spe.2	+	1	453	c.142G>A	c.(142-144)GCC>ACC	p.A48T	uc001spc.2_5'Flank|SLC26A10_uc001spf.2_RNA	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	48	Helical; (Potential).					integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					TGCTCTCCTGGCCTCCGTGCC	0.562													106	678	---	---	---	---	PASS
PPFIA2	8499	broad.mit.edu	37	12	81839428	81839428	+	Silent	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:81839428C>A	uc001szo.1	-	6	638	c.477G>T	c.(475-477)CGG>CGT	p.R159R	PPFIA2_uc010sue.1_Silent_p.R59R|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	85										ovary(3)|lung(2)|pancreas(1)	6						ACTGGGCTTGCCGTTTTACCA	0.428													8	67	---	---	---	---	PASS
TMTC2	160335	broad.mit.edu	37	12	83290168	83290168	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:83290168C>G	uc001szt.2	+	3	1658	c.1226C>G	c.(1225-1227)ACG>AGG	p.T409R	TMTC2_uc001szr.1_Missense_Mutation_p.T409R|TMTC2_uc001szs.1_Missense_Mutation_p.T409R|TMTC2_uc010suk.1_Missense_Mutation_p.T164R	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	409	Helical; (Potential).					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						GTTCCTGCCACGAACCTGTTT	0.418													4	183	---	---	---	---	PASS
SLC5A8	160728	broad.mit.edu	37	12	101555837	101555837	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:101555837G>T	uc001thz.3	-	13	1935	c.1545C>A	c.(1543-1545)AAC>AAA	p.N515K		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	515	Extracellular (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						AAGAATACCAGTTATCCATCA	0.378													19	199	---	---	---	---	PASS
PAH	5053	broad.mit.edu	37	12	103237440	103237440	+	Missense_Mutation	SNP	C	A	A	rs62516103		TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:103237440C>A	uc001tjq.1	-	12	1655	c.1183G>T	c.(1183-1185)GCC>TCC	p.A395S		NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	395			A -> P (in PKU; haplotype 1).|A -> G (in PKU).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	TTCTCCTTGGCATCATTAAAA	0.542													3	40	---	---	---	---	PASS
STAB2	55576	broad.mit.edu	37	12	104031865	104031865	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:104031865A>T	uc001tjw.2	+	8	967	c.781A>T	c.(781-783)AGT>TGT	p.S261C		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	261	Extracellular (Potential).|EGF-like 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AAATCGGCACAGTTGTACATG	0.493													13	154	---	---	---	---	PASS
UBC	7316	broad.mit.edu	37	12	125397618	125397618	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:125397618T>C	uc001ugs.3	-	2	1148	c.700A>G	c.(700-702)AAG>GAG	p.K234E	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Missense_Mutation_p.K234E|UBC_uc001ugt.2_Missense_Mutation_p.K234E|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Missense_Mutation_p.K82E	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	234	Ubiquitin-like 4.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GTGAGTGTCTTCACGAAGATT	0.512													5	232	---	---	---	---	PASS
DHX37	57647	broad.mit.edu	37	12	125473469	125473469	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:125473469G>T	uc001ugy.2	-	1	199	c.100C>A	c.(100-102)CTG>ATG	p.L34M		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	34							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TTACCCTCCAGTTCCAGCTGC	0.706													4	27	---	---	---	---	PASS
TMEM132B	114795	broad.mit.edu	37	12	126135332	126135332	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr12:126135332G>A	uc001uhe.1	+	7	1740	c.1732G>A	c.(1732-1734)GCC>ACC	p.A578T	TMEM132B_uc001uhf.1_Missense_Mutation_p.A90T	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	578	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCAGTTTGTGGCCGAGTCACC	0.592													7	64	---	---	---	---	PASS
POU4F1	5457	broad.mit.edu	37	13	79175769	79175769	+	Silent	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr13:79175769A>G	uc001vkv.2	-	2	1275	c.1041T>C	c.(1039-1041)CCT>CCC	p.P347P	uc001vku.1_Intron	NM_006237	NP_006228	Q01851	PO4F1_HUMAN	POU domain, class 4, transcription factor 1	347					axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		TGAAGAGCTCAGGCTTGTTCA	0.662													3	37	---	---	---	---	PASS
NALCN	259232	broad.mit.edu	37	13	101890232	101890232	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr13:101890232C>A	uc001vox.1	-	12	1497	c.1308G>T	c.(1306-1308)AAG>AAT	p.K436N	NALCN_uc001voy.2_Missense_Mutation_p.K151N|NALCN_uc001voz.2_Missense_Mutation_p.K436N|NALCN_uc001vpa.2_Missense_Mutation_p.K436N	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	436	Helical; Name=S2 of repeat II; (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AACACCATATCTTCAGAAGTG	0.318													12	164	---	---	---	---	PASS
KIAA0586	9786	broad.mit.edu	37	14	58896152	58896152	+	Splice_Site	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr14:58896152G>T	uc001xdv.3	+	2	543	c.270_splice	c.e2+1	p.S90_splice	KIAA0586_uc010trr.1_Splice_Site_p.S90_splice|KIAA0586_uc001xdt.3_Splice_Site_p.S5_splice|KIAA0586_uc001xdu.3_Splice_Site_p.S75_splice|KIAA0586_uc010trs.1_Splice_Site_p.S5_splice|TIMM9_uc010aph.2_5'Flank|TIMM9_uc001xds.2_5'Flank|TIMM9_uc010api.2_5'Flank	NM_014749	NP_055564	E9PGW8	E9PGW8_HUMAN	talpid3 protein											ovary(1)	1						GTCAGAAAGTGTAAGCAAAAG	0.313													4	131	---	---	---	---	PASS
TLN2	83660	broad.mit.edu	37	15	62948154	62948154	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr15:62948154G>T	uc002alb.3	+	5	529	c.529G>T	c.(529-531)GAT>TAT	p.D177Y		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	177	FERM.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						AAATTGGCTGGATCACAGCCG	0.378													12	46	---	---	---	---	PASS
HERC1	8925	broad.mit.edu	37	15	64021766	64021766	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr15:64021766T>C	uc002amp.2	-	15	3099	c.2951A>G	c.(2950-2952)CAT>CGT	p.H984R	HERC1_uc010uil.1_Intron	NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	984					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TTCATGAAGATGAGCAGGCTG	0.368													13	146	---	---	---	---	PASS
CILP	8483	broad.mit.edu	37	15	65489813	65489813	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr15:65489813C>A	uc002aon.2	-	9	2992	c.2811G>T	c.(2809-2811)TGG>TGT	p.W937C		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	937					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						AGTCTTCAGTCCAGCTCATAG	0.532													8	122	---	---	---	---	PASS
CILP	8483	broad.mit.edu	37	15	65489814	65489814	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr15:65489814C>A	uc002aon.2	-	9	2991	c.2810G>T	c.(2809-2811)TGG>TTG	p.W937L		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	937					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						GTCTTCAGTCCAGCTCATAGG	0.532													10	124	---	---	---	---	PASS
CD276	80381	broad.mit.edu	37	15	73996674	73996674	+	Silent	SNP	G	T	T	rs143706609	byFrequency	TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr15:73996674G>T	uc002avv.1	+	6	1464	c.1230G>T	c.(1228-1230)ACG>ACT	p.T410T	CD276_uc010bjd.1_Silent_p.T264T|CD276_uc002avu.1_Silent_p.T410T|CD276_uc002avw.1_Silent_p.T192T|CD276_uc010ulb.1_Silent_p.T356T|CD276_uc002avx.2_RNA	NM_001024736	NP_001019907	Q5ZPR3	CD276_HUMAN	CD276 antigen isoform a	410	Extracellular (Potential).|Ig-like C2-type 2.				cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			skin(1)	1						ACGTGACCACGTCGCAGATGG	0.642											OREG0023265	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	55	---	---	---	---	PASS
CCDC33	80125	broad.mit.edu	37	15	74565187	74565187	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr15:74565187G>T	uc002axo.2	+	7	1108	c.714G>T	c.(712-714)ATG>ATT	p.M238I	CCDC33_uc002axp.2_Missense_Mutation_p.M60I	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	441							protein binding			ovary(3)|skin(2)	5						TCCCGTCCATGATGAACTTTG	0.602													27	87	---	---	---	---	PASS
ANPEP	290	broad.mit.edu	37	15	90347784	90347784	+	Missense_Mutation	SNP	G	A	A	rs8179199	by1000genomes	TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr15:90347784G>A	uc002bop.3	-	5	1254	c.962C>T	c.(961-963)ACG>ATG	p.T321M		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	321	Extracellular.|Interaction with HCoV-229E.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GATGGGGCCCGTCACGTTCAG	0.602													12	119	---	---	---	---	PASS
ASPHD1	253982	broad.mit.edu	37	16	29917137	29917137	+	Silent	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr16:29917137C>A	uc002dut.2	+	3	1238	c.1092C>A	c.(1090-1092)GTC>GTA	p.V364V	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|ASPHD1_uc002duu.3_RNA|ASPHD1_uc010bzi.2_RNA|KCTD13_uc010vee.1_Intron	NM_181718	NP_859069	Q5U4P2	ASPH1_HUMAN	aspartate beta-hydroxylase domain containing 1	364	Lumenal (Potential).				peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity				0						CTCGAGTGGTCTTCATCGTGG	0.602													4	71	---	---	---	---	PASS
MYST1	84148	broad.mit.edu	37	16	31141397	31141397	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr16:31141397C>T	uc002eay.2	+	7	849	c.831C>T	c.(829-831)TAC>TAT	p.Y277Y	MYST1_uc002eax.2_Silent_p.Y277Y|MYST1_uc002eaz.2_Silent_p.Y119Y|MYST1_uc002eba.2_Silent_p.Y61Y|MYST1_uc002ebb.2_RNA	NM_032188	NP_115564	Q9H7Z6	MYST1_HUMAN	MYST histone acetyltransferase 1 isoform 1	277					histone H4-K16 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex|MSL complex	histone acetyltransferase activity|metal ion binding|methylated histone residue binding|transcription factor binding			ovary(1)	1						AGACACTGTACTTTGACGTGG	0.557													10	308	---	---	---	---	PASS
PHKB	5257	broad.mit.edu	37	16	47695636	47695636	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr16:47695636A>G	uc002eev.3	+	23	2255	c.2203A>G	c.(2203-2205)AGT>GGT	p.S735G	PHKB_uc002eeu.3_Missense_Mutation_p.S728G	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	735					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				TCAGGATTGCAGTTGTCTGGC	0.448													19	85	---	---	---	---	PASS
CDH8	1006	broad.mit.edu	37	16	61747850	61747850	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr16:61747850C>G	uc002eog.1	-	10	1801	c.1549G>C	c.(1549-1551)GTT>CTT	p.V517L		NM_001796	NP_001787	P55286	CADH8_HUMAN	cadherin 8, type 2 preproprotein	517	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|skin(2)|breast(1)	9		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		ATGGCGCTAACAGTTTGAATG	0.393													11	75	---	---	---	---	PASS
ZFHX3	463	broad.mit.edu	37	16	72828130	72828130	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr16:72828130G>A	uc002fck.2	-	9	9124	c.8451C>T	c.(8449-8451)TCC>TCT	p.S2817S	ZFHX3_uc002fcl.2_Silent_p.S1903S	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	2817					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				CTGAGGACATGGAGGGGCTTT	0.463													4	130	---	---	---	---	PASS
MYH8	4626	broad.mit.edu	37	17	10315735	10315735	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr17:10315735C>A	uc002gmm.2	-	14	1463	c.1368G>T	c.(1366-1368)AGG>AGT	p.R456S	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	456	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TGAAGTACTGCCTGGGCTGCT	0.483									Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				35	206	---	---	---	---	PASS
KAT2A	2648	broad.mit.edu	37	17	40269416	40269416	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr17:40269416C>T	uc002hyx.2	-	10	1687	c.1627G>A	c.(1627-1629)GTC>ATC	p.V543I		NM_021078	NP_066564	Q92830	KAT2A_HUMAN	general control of amino acid synthesis 5-like	543	N-acetyltransferase.				chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			upper_aerodigestive_tract(1)|lung(1)	2						GGGTCAAAGACGAGGCGGGCG	0.637													6	64	---	---	---	---	PASS
DCAKD	79877	broad.mit.edu	37	17	43111557	43111557	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr17:43111557C>A	uc002ihx.2	-	2	570	c.314G>T	c.(313-315)CGG>CTG	p.R105L	DCAKD_uc010daa.1_Missense_Mutation_p.R105L|DCAKD_uc010dab.1_Missense_Mutation_p.R105L|DCAKD_uc002ihy.2_Missense_Mutation_p.R105L	NM_024819	NP_079095	Q8WVC6	DCAKD_HUMAN	dephospho-CoA kinase domain containing	105	DPCK.				coenzyme A biosynthetic process		ATP binding|dephospho-CoA kinase activity				0		Prostate(33;0.155)				GCACTTACCCCGGAGGAAGTA	0.622													15	42	---	---	---	---	PASS
FMNL1	752	broad.mit.edu	37	17	43321333	43321333	+	Missense_Mutation	SNP	C	A	A	rs138140582		TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr17:43321333C>A	uc002iin.2	+	18	2589	c.2389C>A	c.(2389-2391)CGC>AGC	p.R797S	FMNL1_uc002iiq.2_Missense_Mutation_p.R375S|FMNL1_uc010dag.2_RNA	NM_005892	NP_005883	O95466	FMNL_HUMAN	formin-like 1	797	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			pancreas(1)	1						CCTGCCGGAGCGCATGACCAC	0.662													7	101	---	---	---	---	PASS
MAP2K6	5608	broad.mit.edu	37	17	67515558	67515558	+	Silent	SNP	C	T	T	rs55977235		TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr17:67515558C>T	uc002jij.2	+	5	639	c.351C>T	c.(349-351)GGC>GGT	p.G117G	MAP2K6_uc002jii.2_Silent_p.G117G|MAP2K6_uc002jik.2_Silent_p.G147G	NM_002758	NP_002749	P52564	MP2K6_HUMAN	mitogen-activated protein kinase kinase 6	117	Protein kinase.				activation of MAPK activity|cell cycle arrest|DNA damage induced protein phosphorylation|innate immune response|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of muscle cell differentiation|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|pancreas(1)	5	Breast(10;6.05e-10)					CCTTTTATGGCGCACTGTTTC	0.433													5	212	---	---	---	---	PASS
ITGB4	3691	broad.mit.edu	37	17	73727038	73727038	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr17:73727038C>A	uc002jpg.2	+	9	1272	c.1085C>A	c.(1084-1086)GCC>GAC	p.A362D	ITGB4_uc002jph.2_Missense_Mutation_p.A362D|ITGB4_uc010dgo.2_Missense_Mutation_p.A362D|ITGB4_uc002jpi.3_Missense_Mutation_p.A362D|ITGB4_uc010dgp.1_Missense_Mutation_p.A362D|ITGB4_uc002jpj.2_Missense_Mutation_p.A362D|ITGB4_uc010wsh.1_5'Flank	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	362	Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTGGAGGAGGCCTTCAATGTG	0.612													6	101	---	---	---	---	PASS
RPTOR	57521	broad.mit.edu	37	17	78867568	78867568	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr17:78867568C>T	uc002jyt.1	+	20	3109	c.2304C>T	c.(2302-2304)ACC>ACT	p.T768T	RPTOR_uc010wug.1_Silent_p.T610T	NM_020761	NP_065812	Q8N122	RPTOR_HUMAN	raptor isoform 1	768					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding			lung(4)|urinary_tract(1)|ovary(1)	6						CCAGCAGCACCCTGGGCAGCC	0.667													12	68	---	---	---	---	PASS
ROCK1	6093	broad.mit.edu	37	18	18533574	18533574	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr18:18533574G>A	uc002kte.2	-	32	4967	c.4026C>T	c.(4024-4026)TTC>TTT	p.F1342F		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	1342	Auto-inhibitory.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					CCACTTTCCGGAAAGACTGAT	0.358													5	247	---	---	---	---	PASS
NPC1	4864	broad.mit.edu	37	18	21123435	21123435	+	Silent	SNP	A	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr18:21123435A>T	uc002kum.3	-	14	2503	c.2229T>A	c.(2227-2229)ACT>ACA	p.T743T	NPC1_uc010xaz.1_Silent_p.T476T|NPC1_uc010xba.1_Silent_p.T588T	NM_000271	NP_000262	O15118	NPC1_HUMAN	Niemann-Pick disease, type C1 precursor	743	SSD.				autophagy|bile acid metabolic process|cholesterol efflux|cholesterol homeostasis|lysosomal transport	endoplasmic reticulum|integral to plasma membrane|late endosome membrane|lysosomal membrane|nuclear envelope|perinuclear region of cytoplasm	hedgehog receptor activity|protein binding|sterol transporter activity			ovary(2)	2	all_cancers(21;0.000106)|all_epithelial(16;6.57e-07)|Lung NSC(20;0.00166)|all_lung(20;0.00536)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AAAATGCTACAGTCTCAGAAA	0.488													15	90	---	---	---	---	PASS
ZNF532	55205	broad.mit.edu	37	18	56587032	56587032	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr18:56587032G>C	uc002lho.2	+	4	2060	c.1513G>C	c.(1513-1515)GTC>CTC	p.V505L	ZNF532_uc002lhp.2_Missense_Mutation_p.V503L|ZNF532_uc010xeg.1_Missense_Mutation_p.V503L|ZNF532_uc002lhr.2_Missense_Mutation_p.V503L|ZNF532_uc002lhs.2_Missense_Mutation_p.V503L	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	505					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GCAGCAAACTGTCGTGGTGCC	0.572													5	49	---	---	---	---	PASS
AES	166	broad.mit.edu	37	19	3055671	3055671	+	Silent	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:3055671G>C	uc002lwy.1	-	5	461	c.288C>G	c.(286-288)CTC>CTG	p.L96L	AES_uc002lwx.1_3'UTR|AES_uc002lwz.1_Silent_p.L96L|AES_uc002lxa.1_Silent_p.L40L|AES_uc002lxb.1_Silent_p.L163L|AES_uc002lxc.2_Silent_p.L163L	NM_001130	NP_001121	Q08117	AES_HUMAN	amino-terminal enhancer of split isoform b	96	Gln-rich (Q domain).				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCTTGGGAGAGGTAGGGCA	0.637													4	68	---	---	---	---	PASS
TICAM1	148022	broad.mit.edu	37	19	4817415	4817415	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:4817415G>A	uc002mbi.2	-	2	1226	c.975C>T	c.(973-975)CCC>CCT	p.P325P		NM_182919	NP_891549	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	325	Pro-rich.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			breast(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		TGACAGAGCAGGGGTTTTTGA	0.567													15	88	---	---	---	---	PASS
KIAA1543	57662	broad.mit.edu	37	19	7682718	7682718	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:7682718G>A	uc002mgv.3	+	17	3626	c.3525G>A	c.(3523-3525)CTG>CTA	p.L1175L	KIAA1543_uc002mgu.3_Silent_p.L1202L|KIAA1543_uc002mgw.2_Silent_p.L305L	NM_020902	NP_065953	Q9P1Y5	CAMP3_HUMAN	NEZHA isoform 2	1175	CKK.				epithelial cell-cell adhesion|microtubule anchoring|regulation of microtubule cytoskeleton organization|zonula adherens maintenance	cytoplasm|microtubule|zonula adherens	microtubule minus-end binding			pancreas(1)	1						TCTACACGCTGTCGGGGGAGA	0.612													8	30	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9088858	9088858	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:9088858G>A	uc002mkp.2	-	1	3161	c.2957C>T	c.(2956-2958)TCA>TTA	p.S986L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	986	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGCAGAGGTTGAAACAGTGGT	0.463													14	331	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9089167	9089167	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:9089167C>T	uc002mkp.2	-	1	2852	c.2648G>A	c.(2647-2649)AGA>AAA	p.R883K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	883	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGTCCTTACTCTGGAAACAGA	0.483													3	38	---	---	---	---	PASS
CYP4F8	11283	broad.mit.edu	37	19	15739591	15739591	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:15739591C>T	uc002nbi.2	+	14	1399	c.1335C>T	c.(1333-1335)TTC>TTT	p.F445F	CYP4F8_uc010xoj.1_Silent_p.F257F	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	445					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						CCTTCCGCTTCGACCCAGAAA	0.602													8	83	---	---	---	---	PASS
OR10H3	26532	broad.mit.edu	37	19	15853137	15853137	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:15853137G>T	uc010xoq.1	+	1	935	c.935G>T	c.(934-936)TGC>TTC	p.C312F		NM_013938	NP_039226	O60404	O10H3_HUMAN	olfactory receptor, family 10, subfamily H,	312	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGAAGGTTCTGCCCTCTAAGC	0.323													4	113	---	---	---	---	PASS
ZNF208	7757	broad.mit.edu	37	19	22156774	22156774	+	Silent	SNP	T	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:22156774T>A	uc002nqp.2	-	4	1211	c.1062A>T	c.(1060-1062)TCA>TCT	p.S354S	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAGTAAGGATTGAGAACTTAC	0.398													6	55	---	---	---	---	PASS
ZNF208	7757	broad.mit.edu	37	19	22156775	22156775	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:22156775G>A	uc002nqp.2	-	4	1210	c.1061C>T	c.(1060-1062)TCA>TTA	p.S354L	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGTAAGGATTGAGAACTTACT	0.403													6	55	---	---	---	---	PASS
ZNF99	7652	broad.mit.edu	37	19	22942420	22942420	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:22942420T>A	uc010xrh.1	-	4	354	c.354A>T	c.(352-354)GAA>GAT	p.E118D		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCAATATTATTTCTTGGAAAG	0.313													11	53	---	---	---	---	PASS
ZNF536	9745	broad.mit.edu	37	19	30936147	30936147	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:30936147G>T	uc002nsu.1	+	2	1816	c.1678G>T	c.(1678-1680)GAT>TAT	p.D560Y	ZNF536_uc010edd.1_Missense_Mutation_p.D560Y	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGTTCTGTTTGATAAGGAGAA	0.537													6	136	---	---	---	---	PASS
CEBPG	1054	broad.mit.edu	37	19	33870400	33870400	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:33870400G>A	uc002nup.2	+	2	544	c.255G>A	c.(253-255)CAG>CAA	p.Q85Q		NM_001806	NP_001797	P53567	CEBPG_HUMAN	CCAAT/enhancer binding protein gamma	85	Basic motif.				B cell differentiation|enucleate erythrocyte differentiation|liver development|natural killer cell mediated cytotoxicity|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of DNA binding|positive regulation of DNA repair|positive regulation of interferon-gamma biosynthetic process|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding				0	Esophageal squamous(110;0.137)					AAAGCAAGCAGAAAGCACAAG	0.453													6	25	---	---	---	---	PASS
SIPA1L3	23094	broad.mit.edu	37	19	38610493	38610493	+	Missense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:38610493G>C	uc002ohk.2	+	9	3348	c.2839G>C	c.(2839-2841)GAC>CAC	p.D947H		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	947					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TTCTGTGGAGGACATAAGGGA	0.532													8	44	---	---	---	---	PASS
CEACAM6	4680	broad.mit.edu	37	19	42265883	42265883	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:42265883C>G	uc002orm.2	+	4	859	c.710C>G	c.(709-711)CCA>CGA	p.P237R		NM_002483	NP_002474	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion	237	Ig-like C2-type 2.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		CCAGATGGCCCAGATGGCCCC	0.557													4	136	---	---	---	---	PASS
PSG7	5676	broad.mit.edu	37	19	43430857	43430857	+	Nonsense_Mutation	SNP	T	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:43430857T>A	uc002ovl.3	-	5	823	c.721A>T	c.(721-723)AAG>TAG	p.K241*	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Nonsense_Mutation_p.K119*	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	241	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				ATGTAGGGCTTGGGCAGCTTC	0.468													17	304	---	---	---	---	PASS
PSG6	5675	broad.mit.edu	37	19	43585314	43585314	+	Missense_Mutation	SNP	T	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:43585314T>A	uc002ovi.2	-	2	242	c.149A>T	c.(148-150)GAT>GTT	p.D50V	PSG6_uc010xwk.1_Intron|PSG2_uc002ovr.2_Missense_Mutation_p.D50V|PSG2_uc002ovq.3_Missense_Mutation_p.D50V|PSG2_uc010eiq.1_Missense_Mutation_p.D50V|PSG2_uc002ovs.3_Missense_Mutation_p.D50V|PSG2_uc002ovt.3_Missense_Mutation_p.D50V			Q00889	PSG6_HUMAN	SubName: Full=Putative uncharacterized protein PSG6;	50	Ig-like V-type.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				TAGAAGAACATCCTTCCCCTC	0.468													13	249	---	---	---	---	PASS
NANOS2	339345	broad.mit.edu	37	19	46417622	46417622	+	Silent	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:46417622C>A	uc002pdu.2	-	1	415	c.330G>T	c.(328-330)ACG>ACT	p.T110T		NM_001029861	NP_001025032	P60321	NANO2_HUMAN	nanos homolog 2	110	Nanos-type.|C2HC 2.				germ-line stem cell maintenance|mRNA catabolic process|multicellular organismal development|negative regulation of meiosis|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|perinuclear region of cytoplasm	RNA binding|zinc ion binding				0		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0668)|Epithelial(262;0.231)		AGTACTTGAGCGTATGGGCCT	0.657													6	41	---	---	---	---	PASS
SIGLEC14	100049587	broad.mit.edu	37	19	52147135	52147135	+	Silent	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:52147135G>T	uc002pxf.3	-	5	1029	c.909C>A	c.(907-909)ACC>ACA	p.T303T		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	303	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		GCAGCTCCAGGGTCCCAGACA	0.592													15	58	---	---	---	---	PASS
HAS1	3036	broad.mit.edu	37	19	52220302	52220302	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:52220302G>T	uc002pxo.1	-	3	882	c.847C>A	c.(847-849)CTG>ATG	p.L283M	HAS1_uc010epc.1_Translation_Start_Site|HAS1_uc010epd.1_Missense_Mutation_p.L248M|HAS1_uc002pxn.1_Missense_Mutation_p.L290M|HAS1_uc002pxp.1_Missense_Mutation_p.L282M	NM_001523	NP_001514	Q92839	HAS1_HUMAN	hyaluronan synthase 1	283	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			ovary(1)|pancreas(1)	2		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CAGTATCGCAGGCTGCTTAGG	0.597													16	94	---	---	---	---	PASS
LILRA6	79168	broad.mit.edu	37	19	54744726	54744726	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:54744726G>A	uc002qeu.1	-	5	1060	c.936C>T	c.(934-936)CCC>CCT	p.P312P	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Intron|LILRA6_uc002qek.1_Silent_p.P312P|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Silent_p.P312P|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_RNA|LILRB3_uc002qeo.1_Silent_p.P312P|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Silent_p.P312P|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Intron|LILRA6_uc010yep.1_Silent_p.P312P|LILRA6_uc010yeq.1_Silent_p.P312P|LILRA6_uc002qet.3_RNA|LILRA6_uc002qev.1_Silent_p.P173P	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	312	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGATGTTCAGGGGGTCGCTGG	0.682													14	142	---	---	---	---	PASS
KIR2DS4	3809	broad.mit.edu	37	19	55354355	55354355	+	Missense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:55354355G>A	uc002qhm.1	+	6	743	c.697G>A	c.(697-699)GAA>AAA	p.E233K	KIR2DS4_uc010yfk.1_RNA|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Intron|KIR2DS4_uc002qhn.1_Intron	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	233	Extracellular (Potential).					integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		TTCACCCACTGAACCAAGCTC	0.498													6	296	---	---	---	---	PASS
ZNF304	57343	broad.mit.edu	37	19	57868963	57868963	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr19:57868963C>A	uc010ygw.1	+	3	2114	c.1726C>A	c.(1726-1728)CAA>AAA	p.Q576K	ZNF304_uc010etw.2_Missense_Mutation_p.Q623K|ZNF304_uc010etx.2_Missense_Mutation_p.Q534K	NM_020657	NP_065708	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	576	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CCACCTTGTTCAACACAAGAA	0.483													3	53	---	---	---	---	PASS
PLCB1	23236	broad.mit.edu	37	20	8628584	8628584	+	Missense_Mutation	SNP	C	T	T	rs142186851		TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr20:8628584C>T	uc002wnb.2	+	6	505	c.502C>T	c.(502-504)CGT>TGT	p.R168C	PLCB1_uc010zrb.1_Missense_Mutation_p.R67C|PLCB1_uc010gbv.1_Missense_Mutation_p.R168C|PLCB1_uc002wmz.1_Missense_Mutation_p.R168C|PLCB1_uc002wna.2_Missense_Mutation_p.R168C|PLCB1_uc002wnc.1_Missense_Mutation_p.R67C	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	168					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						TCCAGAAGGGCGTATTCCTCT	0.323													4	116	---	---	---	---	PASS
PTPRT	11122	broad.mit.edu	37	20	41306584	41306584	+	Nonsense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr20:41306584G>A	uc002xkg.2	-	7	1259	c.1075C>T	c.(1075-1077)CGA>TGA	p.R359*	PTPRT_uc010ggj.2_Nonsense_Mutation_p.R359*	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	359	Extracellular (Potential).|Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGGAGCACTCGGATCTCATAC	0.567													18	104	---	---	---	---	PASS
SFRS15	57466	broad.mit.edu	37	21	33067159	33067159	+	Silent	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr21:33067159T>C	uc002ypd.2	-	10	1629	c.1203A>G	c.(1201-1203)CAA>CAG	p.Q401Q	SFRS15_uc002ype.2_Silent_p.Q401Q|SFRS15_uc010glu.2_Silent_p.Q386Q|SFRS15_uc002ypf.1_Silent_p.Q75Q	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	401						nucleus	nucleotide binding|RNA binding				0						GTGGTTCATTTTGTGCCTGAA	0.433													11	56	---	---	---	---	PASS
DYRK1A	1859	broad.mit.edu	37	21	38862490	38862490	+	Silent	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr21:38862490C>G	uc002ywk.2	+	6	753	c.678C>G	c.(676-678)CGC>CGG	p.R226R	DYRK1A_uc002ywi.2_Silent_p.R226R|DYRK1A_uc002ywj.2_Silent_p.R217R|DYRK1A_uc002ywl.2_Silent_p.R226R|DYRK1A_uc002ywm.2_Silent_p.R226R|DYRK1A_uc011aei.1_5'UTR	NM_001396	NP_001387	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	226	Protein kinase.				nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4						ATTTGAAACGCCACTTTATGT	0.348													3	79	---	---	---	---	PASS
PCNT	5116	broad.mit.edu	37	21	47822383	47822383	+	Missense_Mutation	SNP	A	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr21:47822383A>T	uc002zji.3	+	27	5208	c.5101A>T	c.(5101-5103)AAC>TAC	p.N1701Y	PCNT_uc002zjj.2_Missense_Mutation_p.N1583Y	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	1701	Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TGAGGAAGAGAACACGAGCTT	0.493													6	65	---	---	---	---	PASS
PIWIL3	440822	broad.mit.edu	37	22	25115789	25115789	+	Missense_Mutation	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr22:25115789C>T	uc003abd.1	-	20	2875	c.2458G>A	c.(2458-2460)GAC>AAC	p.D820N	PIWIL3_uc011ajx.1_Missense_Mutation_p.D702N|PIWIL3_uc011ajy.1_Missense_Mutation_p.D702N|PIWIL3_uc010gut.1_Missense_Mutation_p.D811N	NM_001008496	NP_001008496	Q7Z3Z3	PIWL3_HUMAN	piwi-like 3	820	Piwi.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			ovary(3)|central_nervous_system(1)	4						CCAATCGTGTCATAGATGACG	0.378													8	63	---	---	---	---	PASS
ISX	91464	broad.mit.edu	37	22	35478545	35478545	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr22:35478545C>T	uc003anj.2	+	2	1215	c.264C>T	c.(262-264)ACC>ACT	p.T88T	ISX_uc011amg.1_Silent_p.T76T	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	88	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						TTCGTACCACCTTCACCACTG	0.562													12	102	---	---	---	---	PASS
CACNA1I	8911	broad.mit.edu	37	22	39994197	39994197	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr22:39994197G>T	uc003ayc.2	+	2	278	c.278G>T	c.(277-279)TGC>TTC	p.C93F	CACNA1I_uc003ayd.2_Missense_Mutation_p.C93F|CACNA1I_uc003aye.2_Missense_Mutation_p.C8F|CACNA1I_uc003ayf.2_Missense_Mutation_p.C8F	NM_021096	NP_066919	Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type,	93	Helical; Name=S1 of repeat I; (Potential).|I.				axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(1)|central_nervous_system(1)	2	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	CTGCTGAACTGCGTGACACTT	0.542													3	16	---	---	---	---	PASS
IL17REL	400935	broad.mit.edu	37	22	50438983	50438983	+	Silent	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr22:50438983G>T	uc003bje.1	-	6	490	c.258C>A	c.(256-258)GCC>GCA	p.A86A		NM_001001694	NP_001001694	Q6ZVW7	I17EL_HUMAN	interleukin 17 receptor E-like	86										pancreas(1)	1		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		AGAGGTGCTGGGCCACGCTCA	0.652													19	92	---	---	---	---	PASS
MAPK11	5600	broad.mit.edu	37	22	50704662	50704662	+	Nonsense_Mutation	SNP	G	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr22:50704662G>C	uc003bkr.2	-	9	813	c.755C>G	c.(754-756)TCA>TGA	p.S252*	MAPK11_uc010hax.2_Nonsense_Mutation_p.S74*|MAPK11_uc011ars.1_RNA|MAPK11_uc010hay.1_RNA|MAPK11_uc011art.1_3'UTR|MAPK11_uc010haz.2_3'UTR	NM_002751	NP_002742	Q15759	MK11_HUMAN	mitogen-activated protein kinase 11	252	Protein kinase.				activation of MAPK activity|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			lung(1)|breast(1)	2		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CACGTGTTCTGAGGAGATTTT	0.607													4	11	---	---	---	---	PASS
ARSA	410	broad.mit.edu	37	22	51065062	51065062	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr22:51065062C>G	uc003bnb.3	-	5	1058	c.805G>C	c.(805-807)GGG>CGG	p.G269R	ARSA_uc003bna.3_Missense_Mutation_p.G185R|ARSA_uc003bnc.3_Missense_Mutation_p.G269R|ARSA_uc003bnd.3_Missense_Mutation_p.G269R|ARSA_uc003bmz.3_Missense_Mutation_p.G269R|ARSA_uc010hbf.2_3'UTR	NM_001085426	NP_001078895	P15289	ARSA_HUMAN	arylsulfatase A isoform a precursor	269						lysosome	arylsulfatase activity|calcium ion binding|cerebroside-sulfatase activity			pancreas(1)|skin(1)	2		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)	Micafungin(DB01141)	TCAAGCAGCCCCAGGTCCCCT	0.642													4	44	---	---	---	---	PASS
SHANK3	85358	broad.mit.edu	37	22	51117757	51117757	+	Silent	SNP	C	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr22:51117757C>T	uc003bne.1	+	7	786	c.786C>T	c.(784-786)CAC>CAT	p.H262H		NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	262										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		GCTTTGGGCACGTGCAGCATC	0.652													12	35	---	---	---	---	PASS
CSF2RA	1438	broad.mit.edu	37	X	1409284	1409284	+	Silent	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chrX:1409284G>A	uc010nct.2	+	8	850	c.528G>A	c.(526-528)GTG>GTA	p.V176V	CSF2RA_uc011mhb.1_Silent_p.V176V|CSF2RA_uc004cpq.2_Silent_p.V176V|CSF2RA_uc004cpn.2_Silent_p.V176V|CSF2RA_uc004cpo.2_Silent_p.V176V|CSF2RA_uc010ncu.2_RNA|CSF2RA_uc011mhc.1_Silent_p.V43V|CSF2RA_uc004cpp.2_Silent_p.V176V|CSF2RA_uc010ncv.2_Silent_p.V176V|CSF2RA_uc004cpr.2_Silent_p.V176V	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	176	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GAACCCATGTGGGATGTCACC	0.353													41	263	---	---	---	---	PASS
MAGEB2	4113	broad.mit.edu	37	X	30236741	30236741	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chrX:30236741G>T	uc004dbz.2	+	2	147	c.44G>T	c.(43-45)CGC>CTC	p.R15L		NM_002364	NP_002355	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	15							protein binding			ovary(1)	1						CGTGAGAAACGCCGCAAGGCC	0.542													5	9	---	---	---	---	PASS
SYTL5	94122	broad.mit.edu	37	X	37953630	37953630	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chrX:37953630C>A	uc004ddu.2	+	9	1448	c.914C>A	c.(913-915)ACT>AAT	p.T305N	SYTL5_uc004ddv.2_Missense_Mutation_p.T305N|SYTL5_uc004ddx.2_Missense_Mutation_p.T305N	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	305					intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						CGCAGAAACACTTCTGGCACA	0.423													9	35	---	---	---	---	PASS
BRWD3	254065	broad.mit.edu	37	X	79945466	79945466	+	Missense_Mutation	SNP	C	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chrX:79945466C>A	uc004edt.2	-	32	3991	c.3728G>T	c.(3727-3729)GGG>GTG	p.G1243V	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.G839V|BRWD3_uc004edp.2_Missense_Mutation_p.G1072V|BRWD3_uc004edq.2_Missense_Mutation_p.G839V|BRWD3_uc010nmj.1_Missense_Mutation_p.G839V|BRWD3_uc004edr.2_Missense_Mutation_p.G913V|BRWD3_uc004eds.2_Missense_Mutation_p.G839V|BRWD3_uc004edu.2_Missense_Mutation_p.G913V|BRWD3_uc004edv.2_Missense_Mutation_p.G839V|BRWD3_uc004edw.2_Missense_Mutation_p.G839V|BRWD3_uc004edx.2_Missense_Mutation_p.G839V|BRWD3_uc004edy.2_Missense_Mutation_p.G839V|BRWD3_uc004edz.2_Missense_Mutation_p.G913V|BRWD3_uc004eea.2_Missense_Mutation_p.G913V|BRWD3_uc004eeb.2_Missense_Mutation_p.G839V	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1243										ovary(4)	4						TGCTTCTTACCCAATAAATCG	0.284													5	26	---	---	---	---	PASS
PCDH11X	27328	broad.mit.edu	37	X	91134254	91134254	+	Silent	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chrX:91134254G>T	uc004efk.1	+	2	3860	c.3015G>T	c.(3013-3015)GTG>GTT	p.V1005V	PCDH11X_uc004efl.1_Silent_p.V1005V|PCDH11X_uc004efo.1_Silent_p.V1005V|PCDH11X_uc010nmv.1_Silent_p.V1005V|PCDH11X_uc004efm.1_Silent_p.V1005V|PCDH11X_uc004efn.1_Silent_p.V1005V|PCDH11X_uc004efh.1_Silent_p.V1005V|PCDH11X_uc004efj.1_Silent_p.V1005V	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1005	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						AGGTACCTGTGTCCGTACACA	0.413													33	83	---	---	---	---	PASS
AMOT	154796	broad.mit.edu	37	X	112033995	112033995	+	Nonsense_Mutation	SNP	G	A	A			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chrX:112033995G>A	uc004epr.2	-	7	1942	c.1942C>T	c.(1942-1944)CAG>TAG	p.Q648*	AMOT_uc004eps.2_Nonsense_Mutation_p.Q239*	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	648	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						TTGGTGGGCTGACAGTTGCCC	0.512													16	45	---	---	---	---	PASS
ODZ1	10178	broad.mit.edu	37	X	123518273	123518273	+	Missense_Mutation	SNP	A	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chrX:123518273A>G	uc004euj.2	-	29	6551	c.6487T>C	c.(6487-6489)TCT>CCT	p.S2163P	ODZ1_uc011muj.1_Missense_Mutation_p.S2169P|ODZ1_uc010nqy.2_Missense_Mutation_p.S2170P	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2163	YD 17.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCATTTACAGAAACAGTCTGA	0.433													3	89	---	---	---	---	PASS
TMEM185A	84548	broad.mit.edu	37	X	148685677	148685677	+	Missense_Mutation	SNP	G	T	T			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chrX:148685677G>T	uc011mxq.1	-	5	794	c.483C>A	c.(481-483)GAC>GAA	p.D161E	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|TMEM185A_uc011mxp.1_Missense_Mutation_p.D102E|TMEM185A_uc004fdo.2_Intron|TMEM185A_uc004fdp.3_Missense_Mutation_p.D78E	NM_032508	NP_115897	Q8NFB2	T185A_HUMAN	transmembrane protein 185A	161	Helical; (Potential).					integral to membrane				ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GGATGATCTTGTCCAGTCTTA	0.249													5	74	---	---	---	---	PASS
MAGEA8	4107	broad.mit.edu	37	X	149013524	149013524	+	Missense_Mutation	SNP	T	C	C			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chrX:149013524T>C	uc004fdw.1	+	3	693	c.478T>C	c.(478-480)TGC>CGC	p.C160R		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	160	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					AGCCTCTGAGTGCATGCAGGT	0.483													5	67	---	---	---	---	PASS
VAMP7	6845	broad.mit.edu	37	X	155127863	155127863	+	Missense_Mutation	SNP	C	G	G			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chrX:155127863C>G	uc004fnr.2	+	4	466	c.292C>G	c.(292-294)CTT>GTT	p.L98V	VAMP7_uc004fnt.2_Missense_Mutation_p.L57V|VAMP7_uc011naa.1_Missense_Mutation_p.L59V|VAMP7_uc011nab.1_5'UTR|VAMP7_uc004fns.2_Missense_Mutation_p.L98V|VAMP7_uc011nac.1_Missense_Mutation_p.L31V	NM_005638	NP_005629	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7 isoform 1	98	Longin.|Cytoplasmic (Potential).			L -> P (in Ref. 5; BAD96514).	calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACAGACAGCACTTCCATATGC	0.393													13	156	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	1	243251439	243251439	+	RNA	DEL	T	-	-			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr1:243251439delT	uc001hzq.1	-	8		c.1193delA								Homo sapiens cDNA FLJ52610 complete cds.																		aaaaaaaaaaTTCCTTTGGGA	0.214													4	2	---	---	---	---	
WNT6	7475	broad.mit.edu	37	2	219724790	219724792	+	In_Frame_Del	DEL	GCT	-	-			TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr2:219724790_219724792delGCT	uc002vjc.1	+	1	245_247	c.30_32delGCT	c.(28-33)GGGCTG>GGG	p.L17del		NM_006522	NP_006513	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family,	17					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(2)|skin(1)	3		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCGCCTCGGGCTGCTGCTGCTG	0.773													4	2	---	---	---	---	
KRTAP2-4	85294	broad.mit.edu	37	17	39221759	39221773	+	In_Frame_Del	DEL	GCAGGGGGGCCGGCA	-	-	rs349782	by1000genomes	TCGA-60-2709-01A-21D-1817-08	TCGA-60-2709-11A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f321c92-ae27-4253-bd8b-4505ba8c7dc4	288537e6-f3c2-47bd-9597-72438bf457a7	g.chr17:39221759_39221773delGCAGGGGGGCCGGCA	uc002hvy.2	-	1	359_373	c.325_339delTGCCGGCCCCCCTGC	c.(325-339)TGCCGGCCCCCCTGCdel	p.CRPPC109del		NM_033184	NP_149440	Q9BYR9	KRA24_HUMAN	keratin associated protein 2-4	109_113						keratin filament					0		Breast(137;0.000496)|Myeloproliferative disorder(1115;0.204)	STAD - Stomach adenocarcinoma(17;0.000371)			TCGGCTGGCCGCAGGGGGGCCGGCAGCAGGGGGAC	0.660													4	2	---	---	---	---