Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF207	7756	broad.mit.edu	37	17	30678932	30678932	+	Splice_Site	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:30678932G>T	ENST00000394670.4	+	2	337		c.e2+1		ZNF207_ENST00000321233.6_Splice_Site|ZNF207_ENST00000341711.6_Intron|ZNF207_ENST00000342555.6_Splice_Site|ZNF207_ENST00000394673.2_Splice_Site|ZNF207_ENST00000577908.1_Splice_Site|RP11-227G15.3_ENST00000581915.1_RNA	NM_001098507.1	NP_001091977.1	O43670	ZN207_HUMAN	zinc finger protein 207							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|lung(3)|urinary_tract(2)	10		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			TTGCATGCAGGTAAGGATTTT	0.348000													5	237					1.23904e-05	1.30018e-05	1	1	0
BTN2A3P	0	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													8	412					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32502566	32502566	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr21:32502566G>A	ENST00000286827.3	-	26	4481	c.4010C>T	c.(4009-4011)aCg>aTg	p.T1337M	TIAM1_ENST00000541036.1_Missense_Mutation_p.T1277M	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1337	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CAGCGCTTCCGTGGGGATCAT	0.483000													6	711					0	0	1	0	0
ZNF43	7594	broad.mit.edu	37	19	21990830	21990830	+	Missense_Mutation	SNP	A	A	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:21990830A>C	ENST00000594012.1	-	7	2505	c.1991T>G	c.(1990-1992)aTa>aGa	p.I664R	ZNF43_ENST00000354959.4_Missense_Mutation_p.I670R|ZNF43_ENST00000598381.1_Missense_Mutation_p.I664R|ZNF43_ENST00000595461.1_Missense_Mutation_p.I664R	NM_001256649.1|NM_001256651.1|NM_001256653.1|NM_001256654.1	NP_001243578.1|NP_001243580.1|NP_001243582.1|NP_001243583.1	P17038	ZNF43_HUMAN	zinc finger protein 43	670					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|prostate(3)|stomach(3)|upper_aerodigestive_tract(2)	51		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		AGTATGAATTATCTTATGTTT	0.368000													6	397					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6853988	6853988	+	Missense_Mutation	SNP	A	A	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:6853988A>T	ENST00000304076.2	+	25	2391	c.2297A>T	c.(2296-2298)aAa>aTa	p.K766I	VAV1_ENST00000599806.1_Missense_Mutation_p.K733I|VAV1_ENST00000596764.1_Missense_Mutation_p.K756I|VAV1_ENST00000539284.1_Missense_Mutation_p.K691I|VAV1_ENST00000602142.1_Missense_Mutation_p.K788I	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	788					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						GGCACAGCCAAAGCCCGCTAT	0.542000													47	556					0	0	1	0	0
EXOC6B	23233	broad.mit.edu	37	2	72411216	72411216	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:72411216G>A	ENST00000272427.6	-	21	2427	c.2297C>T	c.(2296-2298)aCc>aTc	p.T766I	EXOC6B_ENST00000490919.1_5'UTR	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	766					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						CTCAAGCAGGGTCAGAGCAGT	0.507000													3	16					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41739536	41739536	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:41739536G>A	ENST00000352645.4	+	13	1672	c.1415G>A	c.(1414-1416)cGg>cAg	p.R472Q	ZC3H7B_ENST00000351589.4_Missense_Mutation_p.R472Q	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	488					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						ATCCGGCCCCGGCCCACTAAG	0.682000													11	142					0	0	1	0	0
ZNF595	152687	broad.mit.edu	37	4	59339	59339	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:59339G>A	ENST00000509152.2	+	2	205	c.20G>A	c.(19-21)aGg>aAg	p.R7K	ZNF595_ENST00000339368.6_3'UTR|ZNF595_ENST00000526473.2_Missense_Mutation_p.R7K					zinc finger protein 595											endometrium(5)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)	20		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		GTAACATTCAGGGATGTGGCC	0.418000													41	1688					0	0	1	0	0
GLIS3	169792	broad.mit.edu	37	9	3829444	3829444	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:3829444G>C	ENST00000324333.10	-	9	2250	c.2057C>G	c.(2056-2058)tCc>tGc	p.S686C	GLIS3_ENST00000381971.3_Missense_Mutation_p.S841C|GLIS3_ENST00000461870.1_5'UTR	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	686					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		AATTCTCTGGGAATCGGGGTA	0.532000													16	251					0	0	1	0	0
RP11-1166P10.6	0	broad.mit.edu	37	16	32070612	32070612	+	RNA	SNP	A	A	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr16:32070612A>C	ENST00000566806.1	-	0	499																											GGTCTCCTGCAAGGCTTCTGG	0.552000													5	273					0	0	1	0	0
CRTAM	56253	broad.mit.edu	37	11	122726507	122726507	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:122726507C>T	ENST00000227348.4	+	5	642	c.595C>T	c.(595-597)Cga>Tga	p.R199*		NM_019604.2	NP_062550.2	O95727	CRTAM_HUMAN	cytotoxic and regulatory T cell molecule	199	Ig-like C2-type.				cell recognition|detection of tumor cell|positive regulation of cytokine secretion|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|prostate(1)	19		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.28e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0308)		CTGCATTATCCGACACAGAGG	0.393000													116	153					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62296384	62296384	+	Silent	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:62296384A>G	ENST00000378024.4	-	5	5779	c.5505T>C	c.(5503-5505)gaT>gaC	p.D1835D	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1835					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TCAACTTTGCATCAGGACACT	0.522000													9	1045					0	0	1	0	0
UBQLNL	143630	broad.mit.edu	37	11	5536585	5536585	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:5536585T>C	ENST00000380184.1	-	1	1350	c.1087A>G	c.(1087-1089)Att>Gtt	p.I363V	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	363										endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		TTGGTGGAAATCATAGCAGTG	0.488000													68	391					0	0	1	0	0
C17orf97	400566	broad.mit.edu	37	17	263712	263712	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:263712G>A	ENST00000360127.6	+	2	1094	c.1078G>A	c.(1078-1080)Gag>Aag	p.E360K	AC108004.3_ENST00000466740.2_RNA|C17orf97_ENST00000571106.1_Intron	NM_001013672.4	NP_001013694.4	Q6ZQX7	CQ097_HUMAN	chromosome 17 open reading frame 97	390	20 X 10 AA approximative tandem repeat of A-L-K-G-F-H-P-D-P-E.									breast(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)	14						CCCCGACCCCGAGGCCCTCAA	0.682000													5	415					0	0	1	0	0
C22orf42	150297	broad.mit.edu	37	22	32546430	32546430	+	Missense_Mutation	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:32546430C>G	ENST00000382097.3	-	7	602	c.530G>C	c.(529-531)tGt>tCt	p.C177S		NM_001010859.1	NP_001010859.1	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	177										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	24						GTCTTCAAGACAGACAGATAG	0.463000													6	588					0	0	1	0	0
WASH4P	0	broad.mit.edu	37	16	66940	66940	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr16:66940G>A	ENST00000326592.9	-	5	1354	c.696C>T	c.(694-696)agC>agT	p.S232S															p.S232S(1)									GCTCTCTCTTGCTGATGGACA	0.597000													10	167					0	0	1	0	0
ZNF17	7565	broad.mit.edu	37	19	57931756	57931756	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:57931756C>T	ENST00000307658.7	+	4	1165	c.902C>T	c.(901-903)cCa>cTa	p.P301L	ZNF17_ENST00000601808.1_Missense_Mutation_p.P299L|AC004076.7_ENST00000597410.1_Intron			P17021	ZNF17_HUMAN	zinc finger protein 17	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		CACACCAGGCCAAGGCCTTAT	0.468000													28	449					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625956	29625956	+	Missense_Mutation	SNP	G	G	A	rs147809085		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:29625956G>A	ENST00000278882.3	+	5	580	c.200G>A	c.(199-201)aGa>aAa	p.R67K	FRG1B_ENST00000439954.2_Missense_Mutation_p.R72K|FRG1B_ENST00000358464.4_Missense_Mutation_p.R67K														p.R67K(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATTGGACCAAGAGAACAATGG	0.338000													10	506					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43766286	43766286	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:43766286C>T	ENST00000244293.7	-	3	501	c.435G>A	c.(433-435)gaG>gaA	p.E145E	PSG9_ENST00000291752.5_Intron|PSG9_ENST00000443718.3_Intron|PSG9_ENST00000270077.3_Silent_p.E145E|PSG9_ENST00000418820.2_Intron|PSG9_ENST00000596730.1_Intron|PSG9_ENST00000593948.1_Silent_p.E145E			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	145					female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				GCTTGGGAGTCTCCACTGTGC	0.527000													8	947					0	0	1	0	0
SPATA31D5P	0	broad.mit.edu	37	9	84532244	84532244	+	RNA	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:84532244G>A	ENST00000527857.1	+	0	2266					NR_026851.1																						AGGGTCAGAGGTGCAATGTTC	0.448000													14	134					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50724643	50724643	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:50724643T>C	ENST00000404971.1	-	15	4166	c.2827A>G	c.(2827-2829)Ata>Gta	p.I943V	NRXN1_ENST00000401669.2_Missense_Mutation_p.I903V|NRXN1_ENST00000405472.3_Missense_Mutation_p.I895V|NRXN1_ENST00000406859.3_Missense_Mutation_p.I903V|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000402717.3_Missense_Mutation_p.I895V|NRXN1_ENST00000406316.2_Missense_Mutation_p.I903V	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	903	Laminin G-like 5.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GGATCTGCTATGATGTTCCTG	0.418000													13	135					0	0	1	0	0
STAT2	6773	broad.mit.edu	37	12	56742351	56742351	+	Missense_Mutation	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:56742351C>G	ENST00000314128.4	-	19	1709	c.1686G>C	c.(1684-1686)gaG>gaC	p.E562D	STAT2_ENST00000556539.1_5'UTR|STAT2_ENST00000557235.1_Missense_Mutation_p.E558D			P52630	STAT2_HUMAN	signal transducer and activator of transcription 2, 113kDa	562					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|skin(3)	31						CATGTACCAACTCCAGAATTT	0.532000													203	230					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276168	186276168	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:186276168C>T	ENST00000445192.2	+	7	1362	c.1317C>T	c.(1315-1317)acC>acT	p.T439T	PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367485.4_Silent_p.T346T|PRG4_ENST00000367486.3_Silent_p.T396T|PRG4_ENST00000367483.4_Silent_p.T398T	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	439	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CACCCACCACCCCCAAGAAGC	0.657000													5	313					0	0	1	0	0
NMBR	4829	broad.mit.edu	37	6	142399897	142399897	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:142399897C>T	ENST00000258042.1	-	2	706	c.566G>A	c.(565-567)aGc>aAc	p.S189N		NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	189					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		ATTATCCAAGCTACTGATGCG	0.483000													13	498					0	0	1	0	0
CMTM8	152189	broad.mit.edu	37	3	32398865	32398865	+	Splice_Site	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:32398865G>T	ENST00000307526.3	+	2	442	c.147_splice	c.e2-1	p.V50_splice	CMTM8_ENST00000458535.2_Intron	NM_178868.3	NP_849199.2	Q8IZV2	CKLF8_HUMAN	CKLF-like MARVEL transmembrane domain containing 8	50	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			breast(1)|endometrium(1)|kidney(1)|lung(1)	4						CACTTTACAGGTTCTGGGGCT	0.448000													46	528					3.28156e-27	3.73863e-27	1	1	0
SYNJ1	8867	broad.mit.edu	37	21	34003517	34003517	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr21:34003517G>A	ENST00000382491.3	-	28	4493	c.4369C>T	c.(4369-4371)Ctg>Ttg	p.L1457L	SYNJ1_ENST00000433931.2_Silent_p.L1543L|SYNJ1_ENST00000382499.2_3'UTR|SYNJ1_ENST00000357345.3_3'UTR|SYNJ1_ENST00000322229.7_Silent_p.L1504L	NM_001160306.1	NP_001153778.1	O43426	SYNJ1_HUMAN	synaptojanin 1	1504	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						TGATTACCCAGTAAGTCTGAA	0.423000													5	380					0	0	1	0	0
MCHR1	0	broad.mit.edu	37	22	41077549	41077549	+	Missense_Mutation	SNP	G	G	A	rs149149384	byFrequency	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:41077549G>A	ENST00000249016.4	+	2	1582	c.886G>A	c.(886-888)Gca>Aca	p.A296T	MCHR1_ENST00000498400.1_3'UTR|MCHR1_ENST00000381433.2_Missense_Mutation_p.A170T	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	296					elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						CATCACAGCCGCATACGTGAG	0.622000													5	494					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50804981	50804981	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:50804981C>T	ENST00000440075.2	+	40	5580	c.5533C>T	c.(5533-5535)Cgg>Tgg	p.R1845W	MYH14_ENST00000262269.8_Missense_Mutation_p.R1845W|MYH14_ENST00000376970.2_Missense_Mutation_p.R1837W|MYH14_ENST00000425460.1_Missense_Mutation_p.R1812W|MYH14_ENST00000596571.1_Missense_Mutation_p.R1804W|MYH14_ENST00000601313.1_Missense_Mutation_p.R1845W|MYH14_ENST00000598205.1_Missense_Mutation_p.R1812W			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1804					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		AGAGAGCGGGCGGCAGCAGCT	0.622000													39	299					0	0	1	0	0
MAL2	114569	broad.mit.edu	37	8	120255673	120255673	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:120255673C>T	ENST00000276681.6	+	5	578	c.476C>T	c.(475-477)aCg>aTg	p.T159M	RP11-4K16.2_ENST00000522828.1_lincRNA|MAL2_ENST00000521748.1_3'UTR	NM_052886.2	NP_443118.1	Q969L2	MAL2_HUMAN	mal, T-cell differentiation protein 2 (gene/pseudogene)	159	MARVEL.					apical plasma membrane|endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding					all_cancers(13;1.91e-26)|Lung NSC(37;8.61e-08)|Ovarian(258;0.018)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000967)			GCCTTTATGACGACAGCTTGT	0.378000													5	55					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52975368	52975368	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:52975368G>C	ENST00000371544.3	-	4	1161	c.899C>G	c.(898-900)aCc>aGc	p.T300S	ZCCHC11_ENST00000257177.4_Missense_Mutation_p.T300S|ZCCHC11_ENST00000371541.1_5'UTR	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	300					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						CCGACAATTGGTATATTCTGG	0.299000													10	495					0	0	1	0	0
ZNF777	27153	broad.mit.edu	37	7	149152729	149152729	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:149152729C>T	ENST00000247930.4	-	2	708	c.385G>A	c.(385-387)Gtt>Att	p.V129I		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGGGAGTGAACGGGGGCTTCC	0.617000													83	1147					0	0	1	0	0
STAM	8027	broad.mit.edu	37	10	17746472	17746472	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr10:17746472C>T	ENST00000377524.3	+	10	1170	c.955C>T	c.(955-957)Ccc>Tcc	p.P319S	STAM_ENST00000540523.1_Missense_Mutation_p.P208S	NM_003473.3	NP_003464.1	Q92783	STAM1_HUMAN	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	319					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	26						AAGTACAGACCCCAGTGATGA	0.373000													15	639					0	0	1	0	0
SPRR2E	6704	broad.mit.edu	37	1	153066012	153066012	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:153066012C>A	ENST00000368751.1	-	2	290	c.216G>T	c.(214-216)aaG>aaT	p.K72N	SPRR2B_ENST00000368752.4_Intron|SPRR2E_ENST00000368750.3_Missense_Mutation_p.K72N			P22531	SPR2E_HUMAN	small proline-rich protein 2E	72					keratinization	cornified envelope|cytoplasm	protein binding|structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAAGCTGTTACTTGCTCTTGG	0.512000													81	767					3.33908e-46	3.84536e-46	1	1	0
FRS2	10818	broad.mit.edu	37	12	69968596	69968596	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:69968596C>T	ENST00000299293.2	+	10	1898	c.1388C>T	c.(1387-1389)aCc>aTc	p.T463I	FRS2_ENST00000550389.1_Missense_Mutation_p.T463I|FRS2_ENST00000549921.1_Missense_Mutation_p.T463I|FRS2_ENST00000397997.2_Missense_Mutation_p.T463I	NM_001278351.1|NM_006654.3	NP_001265280.1|NP_006645.3	Q8WU20	FRS2_HUMAN	fibroblast growth factor receptor substrate 2	463					activation of MAPKK activity|activation of phospholipase C activity|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|transmembrane receptor protein tyrosine phosphatase signaling pathway	endomembrane system|endosome|integral to plasma membrane|membrane fraction	fibroblast growth factor receptor binding|insulin receptor binding|phosphatase activator activity|transmembrane receptor protein tyrosine kinase adaptor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22	Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.94e-18)|Lung(24;9.68e-05)|OV - Ovarian serous cystadenocarcinoma(12;0.000984)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			CTTCCACAAACCCCTACCAGG	0.493000													5	317					0	0	1	0	0
GAS2	2620	broad.mit.edu	37	11	22696443	22696443	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:22696443C>T	ENST00000454584.2	+	2	333	c.28C>T	c.(28-30)Cgc>Tgc	p.R10C	GAS2_ENST00000533092.1_3'UTR|GAS2_ENST00000433790.1_Missense_Mutation_p.R10C|GAS2_ENST00000278187.3_Missense_Mutation_p.R10C	NM_001143830.1	NP_001137302.1	O43903	GAS2_HUMAN	growth arrest-specific 2	10					cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(4)|stomach(1)	24						CCCAAAGGTACGCAGTGGACC	0.423000													105	143					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628282	29628282	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:29628282G>A	ENST00000278882.3	+	6	664	c.284G>A	c.(283-285)gGg>gAg	p.G95E	FRG1B_ENST00000439954.2_Missense_Mutation_p.G100E|FRG1B_ENST00000358464.4_Missense_Mutation_p.G95E																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATGAAGCAGGGGACATAGAA	0.373000													5	542					0	0	1	0	0
PCDHA3	0	broad.mit.edu	37	5	140182606	140182606	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:140182606G>A	ENST00000522353.2	+	1	1824	c.1824G>A	c.(1822-1824)tcG>tcA	p.S608S	PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000520672.2_Intron|PCDHA3_ENST00000532566.2_Silent_p.S608S|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1												p.S608S(2)		NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGGCTTTCGTATGAGCTGC	0.677000													128	283					0	0	1	0	0
TTLL10	254173	broad.mit.edu	37	1	1115519	1115519	+	Missense_Mutation	SNP	A	A	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:1115519A>T	ENST00000379290.1	+	6	478	c.305A>T	c.(304-306)gAg>gTg	p.E102V	TTLL10_ENST00000379289.1_Missense_Mutation_p.E102V|TTLL10_ENST00000379288.3_Missense_Mutation_p.E29V			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	102					protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCGGACCTGGAGGGGGCAGAA	0.682000													59	32					0	0	1	0	0
SOX6	55553	broad.mit.edu	37	11	16068200	16068200	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:16068200T>C	ENST00000352083.6	-	12	1560	c.1483A>G	c.(1483-1485)Aca>Gca	p.T495A	SOX6_ENST00000527619.1_Missense_Mutation_p.T471A|SOX6_ENST00000528252.1_Missense_Mutation_p.T468A|SOX6_ENST00000396356.3_Missense_Mutation_p.T495A|SOX6_ENST00000316399.6_Missense_Mutation_p.T495A|SOX6_ENST00000528429.1_Missense_Mutation_p.T495A			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	495					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						TTCATCACTGTATCCTGATCC	0.502000													14	255					0	0	1	0	0
KIAA0754	643314	broad.mit.edu	37	1	39879250	39879250	+	Missense_Mutation	SNP	A	A	G	rs783822	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:39879250A>G	ENST00000530275.1	+	1	3100	c.2905A>G	c.(2905-2907)Acc>Gcc	p.T969A	MACF1_ENST00000372915.3_Intron|MACF1_ENST00000289893.4_Intron|MACF1_ENST00000567887.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000564288.1_Intron|MACF1_ENST00000317713.7_Intron	NM_015038.1	NP_055853.1	O94854	K0754_HUMAN	KIAA0754	969	Ala-rich.		T -> A (in dbSNP:rs783822).							central_nervous_system(1)|large_intestine(6)|skin(1)	8	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAGGAGCCCACCTCCCCAGC	0.726000													6	83					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39446905	39446905	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr13:39446905G>A	ENST00000280481.7	+	17	8226	c.8010G>A	c.(8008-8010)gtG>gtA	p.V2670V		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2670					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AGTCCTATGTGACCCTTCGAG	0.443000													6	266					0	0	1	0	0
PDLIM5	10611	broad.mit.edu	37	4	95506861	95506861	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:95506861C>T	ENST00000317968.4	+	6	992	c.856C>T	c.(856-858)Ctt>Ttt	p.L286F	PDLIM5_ENST00000514743.1_Missense_Mutation_p.L183F|PDLIM5_ENST00000437932.1_Missense_Mutation_p.L177F|PDLIM5_ENST00000508216.1_Missense_Mutation_p.L183F|PDLIM5_ENST00000450793.1_Missense_Mutation_p.L183F|PDLIM5_ENST00000538141.1_Missense_Mutation_p.L163F|PDLIM5_ENST00000542407.1_Missense_Mutation_p.L164F|PDLIM5_ENST00000380180.3_Missense_Mutation_p.L183F|PDLIM5_ENST00000380176.3_3'UTR|PDLIM5_ENST00000318007.5_Missense_Mutation_p.L163F	NM_001256428.1|NM_006457.4	NP_001243357.1|NP_006448.4	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5	286					regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		TTTCCGAATCCTTGCCCAGAT	0.468000													13	212					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227872866	227872866	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:227872866G>C	ENST00000396625.3	-	47	4884	c.4677C>G	c.(4675-4677)atC>atG	p.I1559M	COL4A4_ENST00000329662.7_Missense_Mutation_p.I1556M	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1559	Collagen IV NC1.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CATAGGGGCGGATCGCCTCTT	0.657000													21	100					0	0	1	0	0
ACRC	93953	broad.mit.edu	37	X	70824002	70824002	+	Missense_Mutation	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chrX:70824002C>G	ENST00000373695.1	+	7	1412	c.875C>G	c.(874-876)tCg>tGg	p.S292W	ACRC_ENST00000373696.3_Missense_Mutation_p.S292W			Q96QF7	ACRC_HUMAN	acidic repeat containing	292	Asp/Ser-rich.					nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					AGTGATGATTCGGAAGCTTCC	0.527000													22	959					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24593539	24593539	+	Missense_Mutation	SNP	A	A	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:24593539A>T	ENST00000264463.4	-	2	568	c.61T>A	c.(61-63)Tct>Act	p.S21T	RP11-116O11.1_ENST00000510391.1_RNA	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	21					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATTTCTGGAGAGCAGAAATGT	0.408000										HNSCC(23;0.051)			40	591					0	0	1	0	0
CDK17	5128	broad.mit.edu	37	12	96704950	96704950	+	Silent	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:96704950T>C	ENST00000261211.3	-	5	1026	c.423A>G	c.(421-423)ttA>ttG	p.L141L	CDK17_ENST00000542666.1_Silent_p.L88L|CDK17_ENST00000543119.2_Silent_p.L141L	NM_001170464.2|NM_002595.4	NP_001163935.1|NP_002586.2	Q00537	CDK17_HUMAN	cyclin-dependent kinase 17	141							ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(11)|ovary(4)|prostate(2)|skin(1)	37						ACCGCTTATTTAAATCCTTAA	0.343000													18	206					0	0	1	0	0
HRCT1	646962	broad.mit.edu	37	9	35906559	35906559	+	Missense_Mutation	SNP	A	A	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:35906559A>C	ENST00000354323.2	+	1	371	c.275A>C	c.(274-276)cAc>cCc	p.H92P		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	92	His-rich.					integral to membrane		p.H92P(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						caccaccaccacccccgccac	0.682000													16	65					0	0	1	0	0
RABGGTB	5876	broad.mit.edu	37	1	76253257	76253257	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:76253257A>G	ENST00000319942.3	+	2	150	c.79A>G	c.(79-81)Atc>Gtc	p.I27V	RABGGTB_ENST00000535300.1_5'UTR|RABGGTB_ENST00000370826.3_Missense_Mutation_p.I27V|RABGGTB_ENST00000496055.1_3'UTR	NM_004582.2	NP_004573.2	P53611	PGTB2_HUMAN	Rab geranylgeranyltransferase, beta subunit	27					protein modification process|visual perception		metal ion binding|protein binding|Rab geranylgeranyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)	19						TGCAGATTATATCGCATCCTA	0.343000													251	219					0	0	1	0	0
SPATA25	128497	broad.mit.edu	37	20	44515437	44515437	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:44515437G>C	ENST00000372519.3	-	2	447	c.403C>G	c.(403-405)Cta>Gta	p.L135V		NM_080608.3	NP_542175.1	Q9BR10	CT165_HUMAN	spermatogenesis associated 25	135						integral to membrane											GGTACCGGTAGAACCCGTGGT	0.642000													9	644					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													9	223					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87150105	87150105	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:87150105G>A	ENST00000265724.3	-	23	3190	c.2773C>T	c.(2773-2775)Cag>Tag	p.Q925*	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Nonsense_Mutation_p.Q861*	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	925	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TATGGTACCTGCAAACTCTGA	0.403000													5	368					0	0	1	0	0
ARFIP2	23647	broad.mit.edu	37	11	6498495	6498495	+	Missense_Mutation	SNP	T	T	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:6498495T>G	ENST00000254584.2	-	8	957	c.874A>C	c.(874-876)Aag>Cag	p.K292Q	ARFIP2_ENST00000445086.2_Missense_Mutation_p.K207Q|ARFIP2_ENST00000423813.2_Missense_Mutation_p.K254Q|ARFIP2_ENST00000396777.3_Missense_Mutation_p.K292Q	NM_012402.3	NP_036534.1	P53365	ARFP2_HUMAN	ADP-ribosylation factor interacting protein 2	292	AH.				actin cytoskeleton organization|cellular component movement|lamellipodium assembly|ruffle organization|small GTPase mediated signal transduction	cell cortex|plasma membrane|ruffle	GTP binding|GTP-dependent protein binding|Rac GTPase binding			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|pancreas(1)|prostate(1)|skin(2)	15		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;3.41e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGCATCACCTTGATCTGGGGG	0.582000													46	45					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186435487	186435487	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:186435487C>A	ENST00000265023.4	+	1	368	c.156C>A	c.(154-156)aaC>aaA	p.N52K	KNG1_ENST00000447445.1_Missense_Mutation_p.N52K|KNG1_ENST00000287611.2_Missense_Mutation_p.N52K|RP11-573D15.8_ENST00000599314.1_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	52	Cystatin 1.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	AAAGTAACAACCAGTTTGTAT	0.398000													12	317					5.50884e-06	5.79973e-06	1	1	0
SDHAP3	0	broad.mit.edu	37	5	1593261	1593261	+	RNA	SNP	A	A	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:1593261A>T	ENST00000436493.2	-	0	364																											CTCAGGGCACATGCCTGACCA	0.542000													8	293					0	0	1	0	0
HOXA10	3206	broad.mit.edu	37	7	27213854	27213854	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:27213854G>A	ENST00000283921.4	-	1	71	c.72C>T	c.(70-72)ccC>ccT	p.P24P	RP1-170O19.20_ENST00000470747.4_Intron|HOXA10_ENST00000396344.4_Intron|RP1-170O19.20_ENST00000465941.1_Intron	NM_018951.3	NP_061824.3	P31260	HXA10_HUMAN	homeobox A10	24					spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	9						AGTTCGCGGCGGGGCTCTCCG	0.592000													136	233					0	0	1	0	0
CCDC170	80129	broad.mit.edu	37	6	151857487	151857487	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:151857487C>T	ENST00000367290.5	+	2	181	c.92C>T	c.(91-93)aCg>aTg	p.T31M	CCDC170_ENST00000239374.7_Missense_Mutation_p.T31M|CCDC170_ENST00000544131.1_3'UTR			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	31								p.T31M(1)									GTCCCGGTCACGCGGGAGCAG	0.433000													47	331					0	0	1	0	0
TRPV4	59341	broad.mit.edu	37	12	110230501	110230501	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:110230501G>A	ENST00000418703.2	-	10	1874	c.1780C>T	c.(1780-1782)Cgt>Tgt	p.R594C	TRPV4_ENST00000536838.1_Missense_Mutation_p.R560C|TRPV4_ENST00000541794.1_Missense_Mutation_p.R547C|TRPV4_ENST00000392719.2_Missense_Mutation_p.R547C|TRPV4_ENST00000261740.2_Missense_Mutation_p.R594C|TRPV4_ENST00000544971.1_Missense_Mutation_p.R487C|TRPV4_ENST00000346520.2_Missense_Mutation_p.R534C|TRPV4_ENST00000537083.1_Missense_Mutation_p.R534C	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	594			R -> H (in SMDK and PSTD).		actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						TTCAGCCCACGGGTGAAGTAA	0.597000													37	135					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50310602	50310602	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:50310602G>A	ENST00000338821.5	-	7	851	c.587C>T	c.(586-588)aCg>aTg	p.T196M	ATP9A_ENST00000402822.1_Intron|ATP9A_ENST00000311637.5_Intron	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	196					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CTTCCAGTCCGTCTCCCCATC	0.632000													209	313					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3611456	3611456	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:3611456G>C	ENST00000602557.1	-	6	1482	c.927C>G	c.(925-927)ttC>ttG	p.F309L	CSMD1_ENST00000537824.1_Missense_Mutation_p.F309L|CSMD1_ENST00000520002.1_Missense_Mutation_p.F309L|CSMD1_ENST00000602723.1_Missense_Mutation_p.F309L|CSMD1_ENST00000400186.3_Missense_Mutation_p.F309L|CSMD1_ENST00000542608.1_Missense_Mutation_p.F309L|CSMD1_ENST00000539096.1_Missense_Mutation_p.F309L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	309	CUB 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCTTACCTTGGAACTGAGCGT	0.403000													8	200					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													6	725					0	0	1	0	0
KRTAP19-5	337972	broad.mit.edu	37	21	31874370	31874370	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr21:31874370G>A	ENST00000334151.2	-	1	65	c.39C>T	c.(37-39)taC>taT	p.Y13Y		NM_181611.1	NP_853642.1	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	13						intermediate filament	protein binding			endometrium(1)|large_intestine(5)|lung(4)|pancreas(1)|prostate(1)	12						CTCCGTAGCCGTAGCCCAGGC	0.572000													5	418					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2676769	2676769	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:2676769G>A	ENST00000399655.1	+	13	1969	c.1704G>A	c.(1702-1704)acG>acA	p.T568T	CACNA1C_ENST00000399617.1_Silent_p.T568T|CACNA1C_ENST00000335762.5_Silent_p.T593T|CACNA1C_ENST00000399601.1_Silent_p.T568T|CACNA1C_ENST00000399644.1_Silent_p.T568T|CACNA1C_ENST00000399638.1_Silent_p.T568T|CACNA1C_ENST00000399603.1_Silent_p.T568T|CACNA1C_ENST00000399637.1_Silent_p.T568T|CACNA1C_ENST00000399597.1_Silent_p.T568T|CACNA1C_ENST00000480911.1_Silent_p.T568T|CACNA1C_ENST00000399595.1_Silent_p.T568T|CACNA1C_ENST00000344100.3_Silent_p.T568T|CACNA1C_ENST00000402845.3_Silent_p.T568T|CACNA1C_ENST00000406454.3_Silent_p.T568T|CACNA1C_ENST00000399629.1_Silent_p.T568T|CACNA1C_ENST00000399591.1_Silent_p.T568T|CACNA1C_ENST00000347598.4_Silent_p.T568T|CACNA1C_ENST00000399641.1_Silent_p.T568T|CACNA1C_ENST00000399606.1_Silent_p.T568T|CACNA1C_ENST00000399649.1_Silent_p.T568T|CACNA1C_ENST00000399634.1_Silent_p.T568T|CACNA1C_ENST00000399621.1_Silent_p.T568T|CACNA1C_ENST00000327702.7_Silent_p.T568T	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	568					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCCTGTTCACGGCAGAGATGC	0.622000													8	48					0	0	1	0	0
PRAM1	84106	broad.mit.edu	37	19	8555235	8555235	+	Silent	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:8555235A>G	ENST00000423345.4	-	9	2482	c.1962T>C	c.(1960-1962)gaT>gaC	p.D654D	PRAM1_ENST00000255612.3_Silent_p.D653D			Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	702	SH3.						lipid binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)	19						AGAAGTCGACATCATCGTACA	0.667000													4	189					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000600634.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													9	60					2.17888e-05	2.27889e-05	1	1	0
MACROD2	140733	broad.mit.edu	37	20	14066290	14066290	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:14066290C>A	ENST00000217246.4	+	3	582	c.187C>A	c.(187-189)Cag>Aag	p.Q63K	MACROD2_ENST00000310348.4_Missense_Mutation_p.Q63K	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	63	Macro.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				GGAAACATCCCAGGTGAAGAA	0.303000													5	280					0.000602214	0.000619698	1	1	0
FDXR	2232	broad.mit.edu	37	17	72860052	72860052	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:72860052G>A	ENST00000455107.2	-	10	1504	c.1088C>T	c.(1087-1089)tCc>tTc	p.S363F	FDXR_ENST00000413947.2_Silent_p.I411I|FDXR_ENST00000581530.1_Silent_p.I386I|FDXR_ENST00000583917.1_Silent_p.I352I|FDXR_ENST00000582944.1_Silent_p.I372I|FDXR_ENST00000544854.1_Silent_p.I328I|FDXR_ENST00000420580.2_Silent_p.I340I|FDXR_ENST00000293195.5_Silent_p.I380I|FDXR_ENST00000442102.2_Silent_p.I423I			P22570	ADRO_HUMAN	ferredoxin reductase	0					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					CCACATTGGGGATGACCCCAA	0.587000													60	606					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142650922	142650922	+	Missense_Mutation	SNP	A	A	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:142650922A>T	ENST00000355265.2	-	9	1520	c.1046T>A	c.(1045-1047)cTg>cAg	p.L349Q	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	349					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					CTCCTCCACCAGTTGTGACAT	0.532000													10	1739					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50213427	50213427	+	RNA	SNP	T	T	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chrX:50213427T>A	ENST00000376025.2	-	0	310							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					tgtggctggttctggggtcgg	0.642000													8	652					0	0	1	0	0
FAM13B	0	broad.mit.edu	37	5	137289964	137289964	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:137289964C>T	ENST00000033079.3	-	14	1994	c.1543G>A	c.(1543-1545)Gac>Aac	p.D515N	FAM13B_ENST00000420893.2_Missense_Mutation_p.D515N|FAM13B_ENST00000425075.2_Missense_Mutation_p.D419N	NM_016603.2	NP_057687.2	Q9NYF5	FA13B_HUMAN	family with sequence similarity 13, member B	515					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			endometrium(4)|kidney(2)|lung(5)	11						GGAGGACAGTCCTCTTCCAAG	0.468000													39	281					0	0	1	0	0
HIST1H4C	8364	broad.mit.edu	37	6	26104209	26104209	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:26104209G>C	ENST00000377803.2	+	1	106	c.34G>C	c.(34-36)Ggg>Cgg	p.G12R		NM_003542.3	NP_003533.1	P62805	H4_HUMAN	histone cluster 1, H4c	12					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)	7						AAAAGGCTTGGGGAAGGGTGG	0.532000													6	315					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36043993	36043993	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:36043993C>T	ENST00000262623.3	-	18	2725	c.2697G>A	c.(2695-2697)gcG>gcA	p.A899A		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	899					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	CCTCCCACTGCGCCCGCAGCC	0.647000													38	619					0	0	1	0	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651162	1651162	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:1651162G>T	ENST00000399676.2	+	1	130	c.92G>T	c.(91-93)tGt>tTt	p.C31F		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	31				C -> R (in Ref. 1; BAD20201 and 2; CAF31639).		keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		tgtggaggctgtggctctggc	0.716000													6	295					0.217242	0.218613	1	1	0
UBBP4	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000584398.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													5	259					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577547	7577547	+	Missense_Mutation	SNP	C	C	T	rs121912656		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:7577547C>T	ENST00000420246.2	-	7	866	c.734G>A	c.(733-735)gGc>gAc	p.G245D	TP53_ENST00000455263.2_Missense_Mutation_p.G245D|TP53_ENST00000413465.2_Missense_Mutation_p.G245D|TP53_ENST00000269305.4_Missense_Mutation_p.G245D|TP53_ENST00000445888.2_Missense_Mutation_p.G245D|TP53_ENST00000359597.4_Missense_Mutation_p.G245D	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	245	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		G -> A (in sporadic cancers; somatic mutation).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245D(104)|p.G245V(66)|p.G245A(8)|p.0?(8)|p.?(5)|p.G152V(4)|p.G244_M246>V(3)|p.G152D(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.G245fs*2(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.M243fs*18(1)|p.C238_M246delCNSSCMGGM(1)|p.G151_M153>V(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			170	117					0	0	1	0	0
PDE1B	0	broad.mit.edu	37	12	54960852	54960852	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:54960852G>A	ENST00000243052.3	+	3	644	c.208G>A	c.(208-210)Gtc>Atc	p.V70I	PDE1B_ENST00000538346.1_Missense_Mutation_p.V29I|PDE1B_ENST00000550620.1_Missense_Mutation_p.V50I|PDE1B_ENST00000394277.3_3'UTR	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	70					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						GCTGGAAGCCGTCTACATAGA	0.478000													10	83					0	0	1	0	0
SLC26A9	115019	broad.mit.edu	37	1	205904836	205904836	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:205904836C>T	ENST00000367135.3	-	2	226	c.113G>A	c.(112-114)cGc>cAc	p.R38H	SLC26A9_ENST00000340781.4_Missense_Mutation_p.R38H|RP4-681L3.2_ENST00000421166.1_RNA|SLC26A9_ENST00000367134.2_Missense_Mutation_p.R38H	NM_052934.3	NP_443166.1	Q7LBE3	S26A9_HUMAN	solute carrier family 26 (anion exchanger), member 9	38						integral to membrane	chloride channel activity|secondary active sulfate transmembrane transporter activity			NS(1)|breast(3)|endometrium(11)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|skin(7)|urinary_tract(5)	52	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0458)			GAAGGCATTGCGAAGTTTCTC	0.552000													35	316					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276567	186276567	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:186276567C>T	ENST00000445192.2	+	7	1761	c.1716C>T	c.(1714-1716)acC>acT	p.T572T	PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367485.4_Silent_p.T479T|PRG4_ENST00000367486.3_Silent_p.T529T|PRG4_ENST00000367483.4_Silent_p.T531T	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	572	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CACCCACCACCCCCAAGAAGC	0.642000													5	326					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890089	55890089	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:55890089A>G	ENST00000313472.3	+	1	241	c.241A>G	c.(241-243)Aaa>Gaa	p.K81E		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					CGTCACACCTAAAACCTTAGC	0.428000													131	1141					0	0	1	0	0
GLRA4	441509	broad.mit.edu	37	X	102974161	102974161	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chrX:102974161G>A	ENST00000372617.4	-	7	1177	c.757C>T	c.(757-759)Cgg>Tgg	p.R253W		NM_001024452.2	NP_001019623.2	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4	253						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						CCCATCTGCCGTTCCAGGTGA	0.557000													7	608					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4824814	4824814	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:4824814C>T	ENST00000380382.1	-	1	1033	c.1034G>A	c.(1033-1035)cGc>cAc	p.R345H	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron|OR52R1_ENST00000356069.2_Missense_Mutation_p.R266H			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGGCCAAAGCGGTAGGTGAG	0.473000													8	580					0	0	1	0	0
BSND	7809	broad.mit.edu	37	1	55464881	55464881	+	Missense_Mutation	SNP	C	C	T	rs74315285		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:55464881C>T	ENST00000371265.4	+	1	276	c.22C>T	c.(22-24)Cgg>Tgg	p.R8W		NM_057176.2	NP_476517.1	Q8WZ55	BSND_HUMAN	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	8			R -> L (in BS4A; completely abolishes CLCNKA activation; mutated protein fails to increase surface expression of CLCNKA; intracellular localization; probably retained in the ER).|R -> W (in BS4A; completely abolishes CLCNKA activation).			basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17						GAAGACCTTCCGGATCGGCTT	0.622000													14	420					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48563497	48563497	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:48563497C>T	ENST00000358350.4	-	33	4457	c.3853G>A	c.(3853-3855)Gcc>Acc	p.A1285T	FRYL_ENST00000503238.1_Missense_Mutation_p.A1285T|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000507711.1_Missense_Mutation_p.A1285T|FRYL_ENST00000537810.1_Missense_Mutation_p.A1285T	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	1285					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						GAGAATATGGCGAGAGTTAGC	0.358000													245	158					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14620499	14620499	+	Nonsense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:14620499G>A	ENST00000403951.2	-	19	2019	c.1600C>T	c.(1600-1602)Cga>Tga	p.R534*	DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000258767.5_Nonsense_Mutation_p.R534*|DGKB_ENST00000402815.1_Nonsense_Mutation_p.R533*|DGKB_ENST00000399322.3_Nonsense_Mutation_p.R534*|DGKB_ENST00000444700.2_Nonsense_Mutation_p.R515*|DGKB_ENST00000407950.1_Nonsense_Mutation_p.R526*|DGKB_ENST00000406247.3_Nonsense_Mutation_p.R534*			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	534	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	CCTCCCCATCGCAGGCATCTT	0.428000													81	492					0	0	1	0	0
ABCA12	26154	broad.mit.edu	37	2	215848571	215848571	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:215848571C>T	ENST00000272895.7	-	29	4401	c.4182G>A	c.(4180-4182)ctG>ctA	p.L1394L	ABCA12_ENST00000389661.4_Silent_p.L1076L	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	1394	ABC transporter 1.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGGCCCCAAACAGCCCAGTTA	0.403000													62	114					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26377224	26377224	+	Silent	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr10:26377224T>C	ENST00000265944.5	+	15	1618	c.1452T>C	c.(1450-1452)tcT>tcC	p.S484S	MYO3A_ENST00000543632.1_Silent_p.S484S	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	484	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						ATGACAATTCTAGCAGATTTG	0.378000													5	300					0	0	1	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151121990	151121990	+	Silent	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:151121990T>C	ENST00000367328.1	+	7	1077	c.765T>C	c.(763-765)taT>taC	p.Y255Y	PLEKHG1_ENST00000358517.2_Silent_p.Y255Y	NM_001029884.1	NP_001025055.1	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	255	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(19)|ovary(5)|prostate(4)|stomach(1)|urinary_tract(3)	53			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		TTCTCAAGTATCATCTCCTTC	0.448000													9	316					0	0	1	0	0
LINC00966	0	broad.mit.edu	37	8	65291725	65291725	+	RNA	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:65291725C>A	ENST00000521441.1	+	0	655				MIR124-2_ENST00000385081.1_RNA																							AGAGGCTCTGCTCTCCGTGTT	0.527000													5	244					0.248553	0.249334	1	1	0
ZNF519	162655	broad.mit.edu	37	18	14105291	14105291	+	Silent	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr18:14105291A>G	ENST00000590202.1	-	3	1400	c.1248T>C	c.(1246-1248)gcT>gcC	p.A416A	ZNF519_ENST00000589498.1_Intron|ZNF519_ENST00000589203.1_Intron	NM_145287.3	NP_660330.2	Q8TB69	ZN519_HUMAN	zinc finger protein 519	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	18						TAAGGTGTGAAGCTCTGTTAA	0.413000													6	475					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:20414346G>A	ENST00000380338.4	-	5	784	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_ENST00000429426.2_Silent_p.S163S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								5	201					0	0	1	0	0
TIGD5	84948	broad.mit.edu	37	8	144681662	144681662	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:144681662C>T	ENST00000504548.2	+	1	1589	c.1589C>T	c.(1588-1590)gCg>gTg	p.A530V	TIGD5_ENST00000321385.3_Missense_Mutation_p.A481V	NM_032862.4	NP_116251.4	E7EWS2	E7EWS2_HUMAN	tigger transposable element derived 5	530					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding			NS(1)|lung(3)|ovary(1)|soft_tissue(1)|urinary_tract(1)	7	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			GAGGAGGTTGCGGAGTGGCTG	0.731000													11	32					0	0	1	0	0
NEK11	79858	broad.mit.edu	37	3	130881264	130881264	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:130881264C>T	ENST00000383366.4	+	11	1268	c.975C>T	c.(973-975)atC>atT	p.I325I	NEK11_ENST00000511262.1_Silent_p.I325I|NEK11_ENST00000429253.2_Silent_p.I325I|NEK11_ENST00000510688.1_Silent_p.I325I|NEK11_ENST00000356918.4_Silent_p.I325I|NEK11_ENST00000507910.1_Silent_p.I325I|NEK11_ENST00000412440.2_Silent_p.I177I|NEK11_ENST00000508196.1_Silent_p.I325I|NEK11_ENST00000510769.1_Silent_p.I220I	NM_024800.4	NP_079076.3	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11	325					cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|stomach(1)|urinary_tract(2)	33						AAAAAAGGATCCACCTGCAGA	0.423000													108	858					0	0	1	0	0
ZNF519	162655	broad.mit.edu	37	18	14105287	14105287	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr18:14105287G>A	ENST00000590202.1	-	3	1404	c.1252C>T	c.(1252-1254)Cac>Tac	p.H418Y	ZNF519_ENST00000589498.1_Intron|ZNF519_ENST00000589203.1_Intron	NM_145287.3	NP_660330.2	Q8TB69	ZN519_HUMAN	zinc finger protein 519	418					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	18						TGAGTAAGGTGTGAAGCTCTG	0.408000													6	478					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105010418	105010418	+	Missense_Mutation	SNP	T	T	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:105010418T>A	ENST00000507740.1	+	15	2662	c.2426T>A	c.(2425-2427)tTt>tAt	p.F809Y	RIMS2_ENST00000436393.2_Missense_Mutation_p.F795Y|RIMS2_ENST00000406091.3_Intron|RIMS2_ENST00000262231.10_Intron	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1076	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGCAGTCATTTTCTTACTCTA	0.333000										HNSCC(12;0.0054)			12	398					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292822	102292822	+	RNA	SNP	G	G	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:102292822G>C	ENST00000561463.1	+	0	868																											GTGGGAACGAGAAGACACTCG	0.597000													5	89					0	0	1	0	0
OR2V2	285659	broad.mit.edu	37	5	180581955	180581955	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:180581955G>T	ENST00000328275.1	+	1	13	c.13G>T	c.(13-15)Gtg>Ttg	p.V5L		NM_206880.1	NP_996763.1	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V, member 2	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGAGACGTGGGTGAACCAGTC	0.493000													11	365					1.08611e-07	1.15876e-07	1	1	0
MPDZ	8777	broad.mit.edu	37	9	13224583	13224583	+	Splice_Site	SNP	C	C	T	rs10960971		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:13224583C>T	ENST00000319217.7	-	4	431		c.e4-1		MPDZ_ENST00000546205.1_Splice_Site|MPDZ_ENST00000541718.1_Splice_Site|MPDZ_ENST00000447879.1_Splice_Site|MPDZ_ENST00000381015.4_Splice_Site|MPDZ_ENST00000536827.1_Splice_Site|MPDZ_ENST00000381022.2_Splice_Site	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein						interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		CAATATTTACCTAAGAGTAAT	0.333000													5	112					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92715195	92715195	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:92715195G>T	ENST00000257068.2	+	2	812	c.806G>T	c.(805-807)tGc>tTc	p.C269F		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	269					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CCACTTAACTGCATCGGCCTC	0.537000													51	559					1.57914e-17	1.74307e-17	1	1	0
CACNA2D2	9254	broad.mit.edu	37	3	50417244	50417244	+	Missense_Mutation	SNP	A	A	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:50417244A>T	ENST00000435965.1	-	10	1078	c.905T>A	c.(904-906)gTg>gAg	p.V302E	CACNA2D2_ENST00000395083.1_Missense_Mutation_p.V302E|CACNA2D2_ENST00000479441.1_Missense_Mutation_p.V302E|CACNA2D2_ENST00000429770.1_Missense_Mutation_p.V302E|CACNA2D2_ENST00000424201.2_Missense_Mutation_p.V302E|CACNA2D2_ENST00000423994.2_Missense_Mutation_p.V302E|CACNA2D2_ENST00000266039.3_Missense_Mutation_p.V302E|CACNA2D2_ENST00000360963.3_Missense_Mutation_p.V233E			Q9NY47	CA2D2_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 2	302	VWFA.				energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			breast(3)|cervix(1)|endometrium(4)|large_intestine(4)|lung(8)|ovary(2)|prostate(4)|skin(4)|urinary_tract(1)	31				BRCA - Breast invasive adenocarcinoma(193;0.000365)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)	Gabapentin(DB00996)	CAGGCCGCTCACACTGCCACT	0.587000													8	218					0	0	1	0	0
HIST1H3C	8352	broad.mit.edu	37	6	26045691	26045691	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:26045691G>A	ENST00000540144.1	+	1	53	c.53G>A	c.(52-54)cGc>cAc	p.R18H		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	18					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						AAAGCTCCGCGCAAGCAGCTT	0.587000													5	366					0	0	1	0	0
TRIM49C	642612	broad.mit.edu	37	11	89774252	89774252	+	Missense_Mutation	SNP	G	G	A	rs145791878	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:89774252G>A	ENST00000448984.1	+	8	1222	c.893G>A	c.(892-894)aGt>aAt	p.S298N	TRIM49C_ENST00000432771.1_Intron	NM_001195234.1	NP_001182163.1	P0CI26	T49L2_HUMAN	tripartite motif containing 49C	298	B30.2/SPRY.					intracellular	zinc ion binding	p.S298N(4)		endometrium(3)|kidney(1)|lung(4)	8						GAAGCCAACAGTGATATCTTT	0.323000													4	177					0	0	1	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120312438	120312438	+	Missense_Mutation	SNP	T	T	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:120312438T>A	ENST00000397843.2	+	14	1281	c.1115T>A	c.(1114-1116)tTc>tAc	p.F372Y	ARHGEF12_ENST00000356641.3_Missense_Mutation_p.F353Y|ARHGEF12_ENST00000532993.1_Missense_Mutation_p.F269Y	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	372	RGSL.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TGCAGCTGTTTCCAGAGCATT	0.378000			T	MLL	AML								9	432					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100654450	100654450	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:100654450A>G	ENST00000358544.2	+	34	5818	c.5707A>G	c.(5707-5709)Agc>Ggc	p.S1903G	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.S1878G	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1903					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TCTCTTAAGGAGCAGCATTTC	0.428000													8	592					0	0	1	0	0
AGXT2	64902	broad.mit.edu	37	5	35047946	35047946	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:35047946C>T	ENST00000231420.6	-	1	252	c.52G>A	c.(52-54)Gct>Act	p.A18T		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	18					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	ATCCTGGGAGCGGAAGTGACC	0.552000													5	322					0	0	1	0	0
STXBP6	0	broad.mit.edu	37	14	25325188	25325188	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr14:25325188C>T	ENST00000323944.5	-	4	856	c.405G>A	c.(403-405)acG>acA	p.T135T	STXBP6_ENST00000550887.1_Silent_p.T135T|STXBP6_ENST00000396700.1_Silent_p.T135T|STXBP6_ENST00000548724.1_Silent_p.T135T|STXBP6_ENST00000419632.2_Silent_p.T135T|STXBP6_ENST00000546511.1_Silent_p.T135T|STXBP6_ENST00000358326.2_Silent_p.T135T			Q8NFX7	STXB6_HUMAN	syntaxin binding protein 6 (amisyn)	135					vesicle-mediated transport	cytoplasm|integral to membrane				central_nervous_system(2)|endometrium(2)|large_intestine(3)	7				GBM - Glioblastoma multiforme(265;0.0296)		GCTTCCTGTCCGTGAGGTACC	0.443000													24	282					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20243648	20243648	+	Missense_Mutation	SNP	G	G	C	rs149798734		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:20243648G>C	ENST00000245957.5	+	21	2453	c.2377G>C	c.(2377-2379)Gag>Cag	p.E793Q	RP5-1096J16.1_ENST00000460400.1_RNA|C20orf26_ENST00000377293.1_Missense_Mutation_p.E149Q|C20orf26_ENST00000377309.2_Missense_Mutation_p.E149Q|C20orf26_ENST00000389656.3_Missense_Mutation_p.E149Q	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	793										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		GACAAACAGGGAGGTTCCCAA	0.458000													10	542					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123965518	123965518	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:123965518G>T	ENST00000314393.4	+	3	2603	c.1768G>T	c.(1768-1770)Gct>Tct	p.A590S		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	590						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			CATGGAACAAGCTGTCTTGGA	0.567000													5	366					0.000602214	0.000619698	1	1	0
PEG3	5178	broad.mit.edu	37	19	57328548	57328548	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:57328548T>C	ENST00000326441.9	-	10	1625	c.1262A>G	c.(1261-1263)gAg>gGg	p.E421G	ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.E295G|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.E421G|PEG3_ENST00000598410.1_Missense_Mutation_p.E297G|ZIM2_ENST00000391708.3_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	421					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTTTCTCATCTCACTACCACA	0.493000													69	592					0	0	1	0	0
SLC17A7	57030	broad.mit.edu	37	19	49937267	49937267	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:49937267G>C	ENST00000221485.3	-	6	845	c.674C>G	c.(673-675)gCc>gGc	p.A225G	SLC17A7_ENST00000543531.1_Missense_Mutation_p.A213G|SLC17A7_ENST00000600601.1_Missense_Mutation_p.A158G	NM_020309.3	NP_064705.1	Q9P2U7	VGLU1_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 7	225					glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	26		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		AAGGACCCCGGCGAGGGGCAT	0.657000													76	86					0	0	1	0	0
TIGD6	81789	broad.mit.edu	37	5	149375208	149375208	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:149375208G>C	ENST00000296736.3	-	2	1478	c.704C>G	c.(703-705)cCa>cGa	p.P235R	TIGD6_ENST00000515406.2_Missense_Mutation_p.P235R	NM_030953.3	NP_112215.1	Q17RP2	TIGD6_HUMAN	tigger transposable element derived 6	235	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|stomach(1)	10			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			GAGGCAGTGTGGGCTGGCTGA	0.502000													46	212					0	0	1	0	0
ECSIT	51295	broad.mit.edu	37	19	11618812	11618812	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:11618812T>C	ENST00000270517.7	-	5	925	c.790A>G	c.(790-792)Atc>Gtc	p.I264V	ECSIT_ENST00000591352.1_5'UTR|ECSIT_ENST00000591104.1_Missense_Mutation_p.I264V|ECSIT_ENST00000592312.1_Missense_Mutation_p.I148V|ECSIT_ENST00000417981.2_Missense_Mutation_p.I50V|ECSIT_ENST00000252440.7_Missense_Mutation_p.I264V|ECSIT_ENST00000588998.1_Missense_Mutation_p.I50V	NM_016581.4	NP_057665.2	Q9BQ95	ECSIT_HUMAN	ECSIT signalling integrator	264					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						TTACCTACGATGTGGGGCTGG	0.592000													42	295					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19747253	19747253	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:19747253C>T	ENST00000507958.1	-	6	1311	c.321G>A	c.(319-321)acG>acA	p.T107T	CDH18_ENST00000506372.1_Silent_p.T107T|CDH18_ENST00000382275.1_Silent_p.T107T|CDH18_ENST00000274170.4_Silent_p.T107T|CDH18_ENST00000502796.1_Silent_p.T107T|CDH18_ENST00000511273.1_Silent_p.T107T			Q13634	CAD18_HUMAN	cadherin 18, type 2	107	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.T107T(2)		breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GGATATCACCCGTGGTATCGT	0.443000													36	496					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276229	186276229	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:186276229A>G	ENST00000445192.2	+	7	1423	c.1378A>G	c.(1378-1380)Aca>Gca	p.T460A	PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367485.4_Missense_Mutation_p.T367A|PRG4_ENST00000367486.3_Missense_Mutation_p.T417A|PRG4_ENST00000367483.4_Missense_Mutation_p.T419A	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	460	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity	p.T460A(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CAAGGAGCCTACACCCACCAC	0.657000													8	405					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154570940	154570940	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:154570940C>A	ENST00000368474.4	-	3	1922	c.1723G>T	c.(1723-1725)Gcc>Tcc	p.A575S	ADAR_ENST00000292205.5_Missense_Mutation_p.A618S|ADAR_ENST00000368471.3_Missense_Mutation_p.A280S	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102.2|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	575					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		CTGTCCTTGGCTTTGGCTTCC	0.498000													57	381					2.18419e-29	2.49734e-29	1	1	0
OR10H2	26538	broad.mit.edu	37	19	15839203	15839203	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:15839203T>C	ENST00000305899.3	+	1	370	c.350T>C	c.(349-351)gTc>gCc	p.V117A		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					CTGCTCACCGTCATGGGCTAC	0.647000													12	147					0	0	1	0	0
CDC23	8697	broad.mit.edu	37	5	137524808	137524808	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:137524808C>T	ENST00000394886.2	-	16	1683	c.1653G>A	c.(1651-1653)cgG>cgA	p.R551R		NM_004661.3	NP_004652.2	Q9UJX2	CDC23_HUMAN	cell division cycle 23	551					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(6)|prostate(2)|skin(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GTAGGATTTGCCGGAGTAAGG	0.488000													5	333					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23066355	23066355	+	Nonsense_Mutation	SNP	T	T	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:23066355T>A	ENST00000246006.4	-	1	622	c.475A>T	c.(475-477)Aag>Tag	p.K159*		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	159	C-type lectin.				cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					TCAGACCACTTGGGGAGGCGG	0.627000													23	247					0	0	1	0	0
LPL	4023	broad.mit.edu	37	8	19805853	19805853	+	Splice_Site	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:19805853T>C	ENST00000311322.8	+	2	719		c.e2+2		LPL_ENST00000521994.1_Splice_Site	NM_000237.2	NP_000228.1	P06858	LIPL_HUMAN	lipoprotein lipase						fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	36				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	GGCTGGACGGTAAGGGAGGCT	0.562000													12	194					0	0	1	0	0
ARSA	410	broad.mit.edu	37	22	51063767	51063767	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:51063767C>T	ENST00000547307.1	-	8	1735	c.1330G>A	c.(1330-1332)Ggt>Agt	p.G444S	ARSA_ENST00000216124.5_Missense_Mutation_p.G446S|ARSA_ENST00000356098.5_Missense_Mutation_p.G446S|ARSA_ENST00000453344.2_Missense_Mutation_p.G360S|ARSA_ENST00000547805.1_Missense_Mutation_p.G444S|ARSA_ENST00000395619.3_Missense_Mutation_p.G446S|ARSA_ENST00000395621.3_Missense_Mutation_p.G446S			P15289	ARSA_HUMAN	arylsulfatase A	444						lysosome	arylsulfatase activity|calcium ion binding|cerebroside-sulfatase activity			endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|skin(1)	9		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)	Micafungin(DB01141)	CCGGCCACACCCCCCAGCAGG	0.637000													50	504					0	0	1	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:39183145A>G	ENST00000361883.5	-	1	309	c.263T>C	c.(262-264)aTc>aCc	p.I88T		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament		p.I88T(11)		central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632000													16	182					0	0	1	0	0
UPF3A	65110	broad.mit.edu	37	13	115047559	115047559	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr13:115047559C>T	ENST00000375299.3	+	2	327	c.271C>T	c.(271-273)Ctg>Ttg	p.L91L	UPF3A_ENST00000351487.5_Silent_p.L91L	NM_023011.3	NP_075387.1	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A (yeast)	91	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding	p.L91L(8)		autonomic_ganglia(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	16	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		GCTGCGCCCGCTGCCAGCACA	0.731000													5	24					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34052182	34052182	+	Missense_Mutation	SNP	T	T	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:34052182T>G	ENST00000373381.4	-	46	7149	c.6973A>C	c.(6973-6975)Acc>Ccc	p.T2325P		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2327	Sushi 13.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCCACTAAGGTAAAGCCAGGG	0.478000													5	378					0	0	1	0	0
TINAG	27283	broad.mit.edu	37	6	54254644	54254644	+	Missense_Mutation	SNP	T	T	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:54254644T>G	ENST00000259782.4	+	11	1448	c.1352T>G	c.(1351-1353)cTt>cGt	p.L451R		NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	451					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			TTCAGGATTCTTCGAGGAGTA	0.393000													50	506					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167874317	167874317	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:167874317G>T	ENST00000367851.4	-	2	246	c.62C>A	c.(61-63)cCa>cAa	p.P21Q	ADCY10_ENST00000476818.2_Missense_Mutation_p.P21Q|ADCY10_ENST00000367848.1_5'UTR|ADCY10_ENST00000545172.1_Intron	NM_018417.4	NP_060887.2	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	21					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AATGAGGTCTGGTAAATGAGC	0.423000													5	372					0.0293803	0.0299435	1	1	0
TENM1	10178	broad.mit.edu	37	X	123514403	123514403	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chrX:123514403C>T	ENST00000422452.2	-	32	8245	c.8182G>A	c.(8182-8184)Gaa>Aaa	p.E2728K	TENM1_ENST00000371130.3_Missense_Mutation_p.E2721K|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CTGCCTATTTCGCTCTGTCTC	0.373000													30	281					0	0	1	0	0
DRD1	1812	broad.mit.edu	37	5	174869606	174869606	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:174869606G>T	ENST00000393752.2	-	2	1489	c.497C>A	c.(496-498)gCa>gAa	p.A166E		NM_000794.3	NP_000785.1	P21728	DRD1_HUMAN	dopamine receptor D1	166					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|adult walking behavior|cerebral cortex GABAergic interneuron migration|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|mating behavior|positive regulation of cAMP biosynthetic process|positive regulation of cell migration|positive regulation of potassium ion transport|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|response to drug|synapse assembly|visual learning	endoplasmic reticulum membrane|membrane fraction	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(89;0.00895)|Renal(175;0.000159)|Lung NSC(126;0.00625)|all_lung(126;0.0104)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)		Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Carphenazine(DB01038)|Chlorprothixene(DB01239)|Clozapine(DB00363)|Cocaine(DB00907)|Dopamine(DB00988)|Fenoldopam(DB00800)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Methylergonovine(DB00353)|Minaprine(DB00805)|Olanzapine(DB00334)|Pegademase bovine(DB00061)|Pergolide(DB01186)|Perphenazine(DB00850)|Prochlorperazine(DB00433)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Triflupromazine(DB00508)|Zuclopenthixol(DB01624)	TGTGGGTTTTGCCTTGTGCCA	0.532000													30	237					6.00712e-18	6.65372e-18	1	1	0
APOB	338	broad.mit.edu	37	2	21256298	21256298	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:21256298T>C	ENST00000233242.1	-	9	1124	c.997A>G	c.(997-999)Aaa>Gaa	p.K333E	APOB_ENST00000399256.4_Missense_Mutation_p.K333E	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	333	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GTTAGTTTTTTCAGTTCCTGG	0.458000													9	491					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7727300	7727300	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:7727300G>A	ENST00000338316.4	+	14	1886	c.1797G>A	c.(1795-1797)gcG>gcA	p.A599A	RP11-711G10.1_ENST00000514105.2_RNA|ADCY2_ENST00000537121.1_Silent_p.A419A	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	599					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						CACTGCCAGCGTTCAAGTATT	0.502000													101	273					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62654185	62654185	+	Missense_Mutation	SNP	A	A	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:62654185A>T	ENST00000535781.1	+	13	1834	c.1723A>T	c.(1723-1725)Agt>Tgt	p.S575C	ZNF512B_ENST00000217130.3_Intron|ZNF512B_ENST00000450537.1_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	575					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					CAGCAAGAAGAGTGTGTGGCT	0.577000													127	273					0	0	1	0	0
PTPN21	11099	broad.mit.edu	37	14	88967194	88967194	+	Missense_Mutation	SNP	A	A	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr14:88967194A>C	ENST00000556564.1	-	8	981	c.697T>G	c.(697-699)Tcc>Gcc	p.S233A	RP11-507K2.2_ENST00000555444.1_RNA|PTPN21_ENST00000328736.3_Missense_Mutation_p.S233A|PTPN21_ENST00000554628.1_5'UTR	NM_007039.3	NP_008970.2	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type 21	233	FERM.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						GCTCCAATGGATATGTCACTT	0.423000													10	406					0	0	1	0	0
FAM86JP	0	broad.mit.edu	37	3	125647396	125647396	+	RNA	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:125647396T>C	ENST00000485843.1	+	0	541					NR_024251.1																						TGTTTCCCTATGAAGAGCACT	0.502000													12	497					0	0	1	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984296	41984296	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:41984296C>T	ENST00000333141.5	+	1	584	c.487C>T	c.(487-489)Cgg>Tgg	p.R163W		NM_001029955.3	NP_001025126.2	Q3SXM0	DC4L1_HUMAN	DDB1 and CUL4 associated factor 4-like 1	163								p.R163W(1)		breast(1)|endometrium(5)|kidney(6)|large_intestine(11)|lung(12)|prostate(1)|skin(1)	37						CCCAGCGTCGCGGTTCTTAAG	0.587000													39	547					0	0	1	0	0
SLC44A4	80736	broad.mit.edu	37	6	31842799	31842799	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:31842799C>T	ENST00000544672.1	-	5	317	c.21G>A	c.(19-21)aaG>aaA	p.K7K	SLC44A4_ENST00000229729.6_Silent_p.K83K|SLC44A4_ENST00000465707.1_5'UTR|SLC44A4_ENST00000375562.4_Silent_p.K83K	NM_001178045.1	NP_001171516.1	Q53GD3	CTL4_HUMAN	solute carrier family 44, member 4	83						integral to membrane|plasma membrane	choline transmembrane transporter activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(1)|urinary_tract(2)	35					Choline(DB00122)	GGAGATACGGCTTATCTCTGT	0.572000													107	285					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50779289	50779289	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:50779289C>A	ENST00000440075.2	+	28	3556	c.3509C>A	c.(3508-3510)tCc>tAc	p.S1170Y	MYH14_ENST00000262269.8_Missense_Mutation_p.S1170Y|MYH14_ENST00000376970.2_Missense_Mutation_p.S1162Y|MYH14_ENST00000425460.1_Missense_Mutation_p.S1137Y|MYH14_ENST00000596571.1_Missense_Mutation_p.S1129Y|MYH14_ENST00000601313.1_Missense_Mutation_p.S1170Y|MYH14_ENST00000598205.1_Missense_Mutation_p.S1137Y			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1129					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CTGCTGAAATCCCTGCGGGAG	0.667000													76	69					1.21457e-23	1.36425e-23	1	1	0
EVX2	344191	broad.mit.edu	37	2	176947163	176947163	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:176947163C>T	ENST00000308618.4	-	2	578	c.442G>A	c.(442-444)Ggc>Agc	p.G148S		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	148						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		GCAGCCGAGCCGCTCTCTGCG	0.721000													4	134					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180043443	180043443	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:180043443C>T	ENST00000261937.6	-	23	3221	c.3143G>A	c.(3142-3144)aGc>aAc	p.S1048N	FLT4_ENST00000502649.1_Missense_Mutation_p.S1048N|FLT4_ENST00000393347.3_Missense_Mutation_p.S1048N	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	1048	Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CACCACGTCGCTTTCCGACAG	0.612000													8	294					0	0	1	0	0
LSM14B	149986	broad.mit.edu	37	20	60701382	60701382	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:60701382C>A	ENST00000253001.4	+	3	520	c.314C>A	c.(313-315)gCc>gAc	p.A105D	LSM14B_ENST00000279068.6_Missense_Mutation_p.A105D|LSM14B_ENST00000370915.1_Missense_Mutation_p.A105D			Q9BX40	LS14B_HUMAN	LSM14B, SCD6 homolog B (S. cerevisiae)	105					multicellular organismal development|regulation of translation	ribonucleoprotein complex				endometrium(3)|kidney(1)|lung(4)	8	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			TCTGCCTCCGCCTCGCCCTTC	0.662000													7	258					2.74318e-10	2.96635e-10	1	1	0
PRDM9	56979	broad.mit.edu	37	5	23526354	23526354	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:23526354A>G	ENST00000296682.3	+	11	1339	c.1157A>G	c.(1156-1158)gAg>gGg	p.E386G		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	386					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CCAAAGCCAGAGATCCATCCA	0.428000										HNSCC(3;0.000094)			37	680					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34003851	34003851	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:34003851C>T	ENST00000374181.3	-	8	2205	c.2036G>A	c.(2035-2037)cGc>cAc	p.R679H	GRM4_ENST00000374177.3_Missense_Mutation_p.R563H|GRM4_ENST00000544773.1_Missense_Mutation_p.R510H|GRM4_ENST00000455714.2_Missense_Mutation_p.R539H|GRM4_ENST00000538487.1_Missense_Mutation_p.R679H|GRM4_ENST00000535756.1_Missense_Mutation_p.R546H|GRM4_ENST00000545715.1_Missense_Mutation_p.R371H	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	679					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	CTCGAAGATGCGGTAGATGCG	0.627000													5	403					0	0	1	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32504185	32504185	+	Nonsense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:32504185C>A	ENST00000327300.7	+	7	1307	c.1140C>A	c.(1138-1140)taC>taA	p.Y380*	KHDRBS1_ENST00000492989.1_Nonsense_Mutation_p.Y341*|KHDRBS1_ENST00000307714.8_3'UTR	NM_006559.1	NP_006550.1	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal transduction associated 1	380					cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	14		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				AACAAAGTTACGAAGGCTACG	0.398000													5	259					1.06961e-07	1.14499e-07	1	1	0
ACKR3	57007	broad.mit.edu	37	2	237489598	237489598	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:237489598G>A	ENST00000272928.3	+	2	800	c.490G>A	c.(490-492)Gtc>Atc	p.V164I		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		ACGCCGTGTCGTCTGCATCCT	0.572000													7	398					0	0	1	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15115677	15115677	+	Missense_Mutation	SNP	C	C	T	rs147577833	byFrequency	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:15115677C>T	ENST00000253699.3	-	14	2580	c.1967G>A	c.(1966-1968)cGc>cAc	p.R656H	ZFYVE20_ENST00000476527.2_Missense_Mutation_p.R656H	NM_022340.2	NP_071735.2	Q9H1K0	RBNS5_HUMAN	zinc finger, FYVE domain containing 20	656	Necessary for the interaction with EHD1.|Necessary for the interaction with RAB5A.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|skin(3)|stomach(1)|urinary_tract(2)	26						TTTCAGGATGCGGGCTGAAGG	0.562000													6	851					0	0	1	0	0
OR51B5	282763	broad.mit.edu	37	11	5364535	5364535	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:5364535T>C	ENST00000300773.2	-	1	274	c.220A>G	c.(220-222)Acc>Gcc	p.T74A	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	74					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T74A(1)		NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCATTGTGGTCAGGGCCAGC	0.542000													24	171					0	0	1	0	0
MYL3	4634	broad.mit.edu	37	3	46902236	46902236	+	Silent	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:46902236G>T	ENST00000395869.1	-	3	288	c.237C>A	c.(235-237)gtC>gtA	p.V79V	MYL3_ENST00000292327.4_Silent_p.V79V			P08590	MYL3_HUMAN	myosin, light chain 3, alkali; ventricular, skeletal, slow	79	EF-hand 1.				cardiac muscle contraction|muscle filament sliding|positive regulation of ATPase activity|regulation of striated muscle contraction|regulation of the force of heart contraction|ventricular cardiac muscle tissue morphogenesis	A band|cytosol|I band|muscle myosin complex	actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			breast(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(193;0.00116)|KIRC - Kidney renal clear cell carcinoma(197;0.00557)|Kidney(197;0.0063)		GCGCCCGCAGGACATCCCCAC	0.607000													53	385					1.39843e-22	1.56526e-22	1	1	0
PTPRT	11122	broad.mit.edu	37	20	41400107	41400107	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:41400107T>C	ENST00000373198.3	-	5	887	c.652A>G	c.(652-654)Aag>Gag	p.K218E	PTPRT_ENST00000373184.1_Missense_Mutation_p.K218E|PTPRT_ENST00000356100.2_Missense_Mutation_p.K218E|PTPRT_ENST00000373187.1_Missense_Mutation_p.K218E|PTPRT_ENST00000373193.3_Missense_Mutation_p.K218E|PTPRT_ENST00000373201.1_Missense_Mutation_p.K218E|PTPRT_ENST00000373190.1_Missense_Mutation_p.K218E	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	218	Ig-like C2-type.		K -> T (in a gastric cancer).		homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGAGACCACTTCCCACCAGCA	0.483000													479	919					0	0	1	0	0
GC	2638	broad.mit.edu	37	4	72618261	72618261	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:72618261A>G	ENST00000273951.8	-	11	1712	c.1369T>C	c.(1369-1371)Tca>Cca	p.S457P	GC_ENST00000504199.1_Missense_Mutation_p.S476P|GC_ENST00000513476.1_Missense_Mutation_p.S457P|GC_ENST00000503472.1_5'UTR	NM_000583.3|NM_001204306.1	NP_000574.2|NP_001191235.1	P02774	VTDB_HUMAN	group-specific component (vitamin D binding protein)	457	Albumin 3.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	45		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	AGAGGAGGTGAGTTTATGGAA	0.438000													5	350					0	0	1	0	0
ERRFI1	54206	broad.mit.edu	37	1	8073413	8073413	+	Nonsense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:8073413C>A	ENST00000377482.5	-	4	1469	c.1246G>T	c.(1246-1248)Gaa>Taa	p.E416*	ERRFI1_ENST00000474874.1_Intron	NM_018948.3	NP_061821.1	Q9UJM3	ERRFI_HUMAN	ERBB receptor feedback inhibitor 1	416					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			breast(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(3)|ovary(1)|prostate(1)|skin(2)	16	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CCATTTGTTTCTTCTGCTTCC	0.413000													9	721					5.4927e-09	5.89957e-09	1	1	0
CD5L	922	broad.mit.edu	37	1	157804321	157804321	+	Silent	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:157804321T>C	ENST00000368174.4	-	4	690	c.594A>G	c.(592-594)cgA>cgG	p.R198R		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	198	SRCR 2.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGATGGGTTTTCGGCCATAGG	0.587000													27	262					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179297387	179297387	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:179297387G>A	ENST00000356834.3	-	16	2630	c.2593C>T	c.(2593-2595)Cgg>Tgg	p.R865W	TBC1D9B_ENST00000444477.2_Missense_Mutation_p.R23W|TBC1D9B_ENST00000519746.1_Missense_Mutation_p.R41W|TBC1D9B_ENST00000355235.3_Missense_Mutation_p.R865W	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	865						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGAGTTCCCGGAACTGGCTG	0.647000													152	258					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	62948259	62948259	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:62948259G>A	ENST00000561311.1	+	7	864	c.634G>A	c.(634-636)Gtg>Atg	p.V212M	TLN2_ENST00000306829.6_Missense_Mutation_p.V212M			Q9Y4G6	TLN2_HUMAN	talin 2	212	FERM.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						GAGAGACCCCGTGCAGCTGAA	0.463000													36	288					0	0	1	0	0
POTEE	445582	broad.mit.edu	37	2	131976197	131976197	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:131976197G>A	ENST00000356920.5	+	1	316	c.222G>A	c.(220-222)ggG>ggA	p.G74G	PLEKHB2_ENST00000404460.1_Intron|POTEE_ENST00000358087.5_Silent_p.G74G|PLEKHB2_ENST00000303908.3_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	74							ATP binding										GCTGCAGGGGGAGTGGCAAGA	0.587000													44	870					0	0	1	0	0
RNF44	22838	broad.mit.edu	37	5	175956566	175956566	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:175956566G>A	ENST00000274811.4	-	9	1618	c.1094C>T	c.(1093-1095)tCg>tTg	p.S365L	RNF44_ENST00000537487.1_Missense_Mutation_p.S284L	NM_014901.4	NP_055716.1	Q7L0R7	RNF44_HUMAN	ring finger protein 44	365							zinc ion binding			endometrium(2)|lung(3)|prostate(1)|skin(1)|stomach(1)	8	all_cancers(89;0.0029)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAAGCGGTACGACGGGAGCTG	0.662000													30	230					0	0	1	0	0
TSPAN5	10098	broad.mit.edu	37	4	99399943	99399943	+	Missense_Mutation	SNP	A	A	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:99399943A>T	ENST00000305798.3	-	5	871	c.469T>A	c.(469-471)Ttt>Att	p.F157I	TSPAN5_ENST00000509168.1_5'UTR|TSPAN5_ENST00000505184.1_Missense_Mutation_p.F86I	NM_005723.3	NP_005714.2	P62079	TSN5_HUMAN	tetraspanin 5	157						integral to membrane				kidney(2)|large_intestine(6)|lung(5)|upper_aerodigestive_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(123;1.89e-07)		TCAGCTCCAAAAGCCCCACAG	0.483000													14	174					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13883067	13883067	+	Nonsense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:13883067G>T	ENST00000265104.4	-	20	3224	c.3120C>A	c.(3118-3120)tgC>tgA	p.C1040*	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1040	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CACTGATGATGCACTCCACGG	0.532000									Kartagener syndrome				40	634					9.14704e-12	9.99283e-12	1	1	0
POTEH	23784	broad.mit.edu	37	22	16287662	16287662	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:16287662C>A	ENST00000343518.6	-	1	275	c.224G>T	c.(223-225)aGc>aTc	p.S75I		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	75										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						GCTCTTGCCGCTCCCCCTGCA	0.582000													13	1329					0.000602214	0.000619698	1	1	0
RUVBL2	10856	broad.mit.edu	37	19	49513093	49513093	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:49513093G>A	ENST00000413176.2	+	7	1536	c.388G>A	c.(388-390)Ggc>Agc	p.G130S	RUVBL2_ENST00000601968.1_Missense_Mutation_p.G130S|RUVBL2_ENST00000595090.1_Missense_Mutation_p.G175S			Q9Y230	RUVB2_HUMAN	RuvB-like AAA ATPase 2	175					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding			large_intestine(1)|upper_aerodigestive_tract(1)	2		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		CTACGACCTGGGCACCAAGAT	0.632000													6	567					0	0	1	0	0
DENND2C	163259	broad.mit.edu	37	1	115143483	115143483	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:115143483G>A	ENST00000393274.1	-	14	2539	c.1914C>T	c.(1912-1914)cgC>cgT	p.R638R	DENND2C_ENST00000393277.1_Silent_p.R638R|DENND2C_ENST00000481894.1_5'UTR|DENND2C_ENST00000393276.3_Silent_p.R581R	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	638	DENN.									NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGTGATGGTGCGTCCAGGAG	0.448000													14	423					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212498	62212498	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:62212498G>T	ENST00000519846.1	+	3	584	c.112G>T	c.(112-114)Gct>Tct	p.A38S	CLVS1_ENST00000518592.1_Intron|CLVS1_ENST00000325897.4_Missense_Mutation_p.A38S			Q8IUQ0	CLVS1_HUMAN	clavesin 1	38					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						TATAGAGAAAGCTCGCCTGGA	0.438000													8	255					0.000274275	0.000284996	1	1	0
TMPRSS6	164656	broad.mit.edu	37	22	37485772	37485772	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:37485772C>A	ENST00000381792.2	-	7	822	c.682G>T	c.(682-684)Ggg>Tgg	p.G228W	TMPRSS6_ENST00000442782.2_Missense_Mutation_p.G237W|TMPRSS6_ENST00000406725.1_Missense_Mutation_p.G228W|TMPRSS6_ENST00000406856.1_Missense_Mutation_p.G228W|TMPRSS6_ENST00000346753.3_Missense_Mutation_p.G237W			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	237	CUB 1.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						TGGTCAGGCCCCTTCAGCCGG	0.667000													4	92					0.150653	0.152084	1	1	0
NXF5	55998	broad.mit.edu	37	X	101091708	101091708	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chrX:101091708G>T	ENST00000361708.2	-	16	1537	c.1178C>A	c.(1177-1179)cCa>cAa	p.P393Q	NXF5_ENST00000473265.2_Intron|NXF5_ENST00000537026.1_Intron			Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	393					mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|skin(1)	30						GCACTAACCTGGAATTGCGGC	0.522000													9	398					2.74318e-10	2.96635e-10	1	1	0
IL36G	56300	broad.mit.edu	37	2	113742500	113742500	+	Silent	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:113742500C>A	ENST00000259205.4	+	5	453	c.384C>A	c.(382-384)tcC>tcA	p.S128S	IL36G_ENST00000376489.2_Silent_p.S93S	NM_019618.2	NP_062564.1	Q9NZH8	IL36G_HUMAN	interleukin 36, gamma	128					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						GTAGGACCTCCACCCTTGAGT	0.517000													312	241					1.20034e-152	1.39239e-152	1	1	0
KLHL14	57565	broad.mit.edu	37	18	30349623	30349623	+	Missense_Mutation	SNP	T	T	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr18:30349623T>A	ENST00000359358.4	-	2	1370	c.932A>T	c.(931-933)cAg>cTg	p.Q311L	KLHL14_ENST00000358095.4_Missense_Mutation_p.Q311L	NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	311						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GGCCAGGCTCTGCCTGCAGTG	0.647000													23	232					0	0	1	0	0
SLC4A4	8671	broad.mit.edu	37	4	72317017	72317017	+	Splice_Site	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:72317017C>T	ENST00000340595.3	+	8	1385	c.1190_splice	c.e8+1	p.R397_splice	SLC4A4_ENST00000514331.1_3'UTR|SLC4A4_ENST00000264485.5_Splice_Site_p.R441_splice|SLC4A4_ENST00000425175.1_Splice_Site_p.R441_splice|SLC4A4_ENST00000351898.6_Splice_Site_p.R441_splice|SLC4A4_ENST00000512686.1_Splice_Site_p.R397_splice	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	441						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity	p.R397W(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GCGAACTGGACGGTAACTGAC	0.438000													10	211					0	0	1	0	0
PRR22	163154	broad.mit.edu	37	19	5783697	5783697	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:5783697G>A	ENST00000419421.2	-	3	665	c.561C>T	c.(559-561)ccC>ccT	p.P187P		NM_001134316.1	NP_001127788.1	Q8IZ63	PRR22_HUMAN	proline rich 22	185	Pro-rich.									endometrium(2)|large_intestine(1)|prostate(1)|urinary_tract(1)	5						TCTCCTTGGGGGGTGGGGGTG	0.701000													6	19					0	0	1	0	0
ARRB2	409	broad.mit.edu	37	17	4621608	4621608	+	Missense_Mutation	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:4621608C>G	ENST00000269260.2	+	9	907	c.674C>G	c.(673-675)tCc>tGc	p.S225C	ARRB2_ENST00000381488.6_Missense_Mutation_p.S210C|ARRB2_ENST00000575877.1_Missense_Mutation_p.S225C|ARRB2_ENST00000571206.1_Missense_Mutation_p.S33C|ARRB2_ENST00000412477.3_Missense_Mutation_p.S246C|ARRB2_ENST00000574954.1_Missense_Mutation_p.S33C|ARRB2_ENST00000346341.2_Missense_Mutation_p.S210C|ARRB2_ENST00000572457.1_Missense_Mutation_p.S33C	NM_001257328.1|NM_001257330.1|NM_004313.3	NP_001244257.1|NP_001244259.1|NP_004304.1	P32121	ARRB2_HUMAN	arrestin, beta 2	225					cell chemotaxis|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|G-protein coupled receptor internalization|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway	coated pit|cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	angiotensin receptor binding|ubiquitin protein ligase binding			large_intestine(1)|liver(2)|lung(3)|prostate(1)	7						ACCAACAACTCCACCAAGACC	0.537000													80	43					0	0	1	0	0
SEL1L	6400	broad.mit.edu	37	14	81952666	81952666	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr14:81952666C>T	ENST00000336735.4	-	17	1881	c.1765G>A	c.(1765-1767)Gca>Aca	p.A589T		NM_005065.5	NP_005056.3	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like (C. elegans)	589	Interaction with ERLEC1, OS9 and SYVN1.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding	p.A589T(1)		breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	28				BRCA - Breast invasive adenocarcinoma(234;0.0299)		TTGCTTTGTGCCACTTCATAG	0.428000													8	1295					0	0	1	0	0
MNS1	55329	broad.mit.edu	37	15	56735721	56735721	+	Silent	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:56735721T>C	ENST00000260453.3	-	7	1082	c.918A>G	c.(916-918)ttA>ttG	p.L306L	TEX9_ENST00000537232.1_Intron|TEX9_ENST00000352903.2_Intron	NM_018365.2	NP_060835.1	Q8NEH6	MNS1_HUMAN	meiosis-specific nuclear structural 1	306	Glu-rich.				meiosis					breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	20				all cancers(107;0.0196)|GBM - Glioblastoma multiforme(80;0.101)		GCATTTCTTCTAATTTCTGTG	0.289000													19	261					0	0	1	0	0
ZNF844	284391	broad.mit.edu	37	19	12187443	12187443	+	Missense_Mutation	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:12187443C>G	ENST00000439326.3	+	4	1683	c.1508C>G	c.(1507-1509)cCt>cGt	p.P503R	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	503					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P503R(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						GAGAGAAACCCTATGAGTGTA	0.413000													5	295					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50071192	50071192	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:50071192T>C	ENST00000371564.3	-	6	1961	c.1742A>G	c.(1741-1743)gAa>gGa	p.E581G	NFATC2_ENST00000396009.3_Missense_Mutation_p.E581G|NFATC2_ENST00000414705.1_Missense_Mutation_p.E561G	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	581					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GTCTTGTCTTTCAACCATGGG	0.507000													95	912					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999078	143999078	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:143999078C>T	ENST00000323110.2	-	1	181	c.179G>A	c.(178-180)gGt>gAt	p.G60D		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	60					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GTGCTCATAACCCTGCTCCCT	0.632000									Familial Hyperaldosteronism type I				30	285					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69933955	69933955	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr10:69933955G>A	ENST00000358913.5	+	11	2594	c.2106G>A	c.(2104-2106)gcG>gcA	p.A702A	MYPN_ENST00000540630.1_Silent_p.A702A|MYPN_ENST00000354393.2_Silent_p.A427A	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	702						nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						CTCCCCCAGCGGTGACAACAT	0.507000													7	400					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106811110	106811110	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:106811110T>C	ENST00000407775.2	+	7	1148	c.898T>C	c.(898-900)Ttc>Ctc	p.F300L	RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.F31L|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.F168L|ZFPM2_ENST00000517361.1_Missense_Mutation_p.F168L|RP11-152P17.2_ENST00000521622.1_RNA|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	300					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CCTGTGCCCCTTCCCACAGTG	0.498000													10	760					0	0	1	0	0
NNT	23530	broad.mit.edu	37	5	43624207	43624207	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:43624207G>A	ENST00000264663.5	+	6	982	c.761G>A	c.(760-762)cGa>cAa	p.R254Q	NNT_ENST00000512996.2_Missense_Mutation_p.R123Q|NNT_ENST00000344920.4_Missense_Mutation_p.R254Q	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	254					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	GCAATTGTTCGAGGATTTGAC	0.418000													89	2205					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161027656	161027656	+	Missense_Mutation	SNP	G	G	C	rs145350443	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:161027656G>C	ENST00000447678.1	-	18	2758	c.2638C>G	c.(2638-2640)Cct>Gct	p.P880A	LPA_ENST00000316300.5_Missense_Mutation_p.P880A	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3388	Kringle 8.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GCTGCCACAGGATCTGGATTC	0.542000													8	817					0	0	1	0	0
SNX10	29887	broad.mit.edu	37	7	26400616	26400616	+	Nonsense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:26400616C>T	ENST00000338523.4	+	3	233	c.46C>T	c.(46-48)Cga>Tga	p.R16*	SNX10_ENST00000409367.1_5'UTR|SNX10_ENST00000396376.1_Nonsense_Mutation_p.R16*|SNX10_ENST00000446848.2_Nonsense_Mutation_p.R42*	NM_001199835.1|NM_013322.2	NP_001186764.1|NP_037454.2	Q9Y5X0	SNX10_HUMAN	sorting nexin 10	16	PX.				cell communication|endosome organization|protein transport	extrinsic to endosome membrane	1-phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	6						TGTCTGGGTTCGAGATCCTAG	0.368000													133	357					0	0	1	0	0
PPM1E	22843	broad.mit.edu	37	17	57057995	57057995	+	Missense_Mutation	SNP	G	G	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:57057995G>C	ENST00000308249.2	+	7	2000	c.1871G>C	c.(1870-1872)gGa>gCa	p.G624A		NM_014906.4	NP_055721.3	Q8WY54	PPM1E_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1E	633					protein dephosphorylation	cytoplasm|nucleolus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Medulloblastoma(34;0.127)|all_neural(34;0.237)		BRCA - Breast invasive adenocarcinoma(1;5.76e-11)			AGTGGTGCTGGAGAGTTTCCC	0.423000													5	573					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117232055	117232055	+	Missense_Mutation	SNP	A	A	G	rs121908777		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:117232055A>G	ENST00000003084.6	+	14	1966	c.1834A>G	c.(1834-1836)Aaa>Gaa	p.K612E	CFTR_ENST00000454343.1_Missense_Mutation_p.K551E	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	612	ABC transporter 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	ACATTTAAAGAAAGCTGACAA	0.303000									Cystic Fibrosis				5	387					0	0	1	0	0
KRTAP26-1	388818	broad.mit.edu	37	21	31692132	31692132	+	Silent	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr21:31692132G>T	ENST00000360542.3	-	1	475	c.222C>A	c.(220-222)ggC>ggA	p.G74G		NM_203405.1	NP_981950.1	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	74						intermediate filament				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16						TTTCAAGATTGCCGGTCTCAC	0.542000													11	485					5.50884e-06	5.79973e-06	1	1	0
DPY19L2P1	0	broad.mit.edu	37	7	35131480	35131480	+	RNA	SNP	A	A	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:35131480A>T	ENST00000436258.1	-	0	1889																											ATCTTCGTAAAGTGGATGATT	0.423000													5	344					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70152481	70152481	+	Silent	SNP	A	A	G	rs141618560		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:70152481A>G	ENST00000335568.5	+	3	884	c.882A>G	c.(880-882)gaA>gaG	p.E294E	UGT2B28_ENST00000511240.1_Silent_p.E294E	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	294					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.E294E(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	AAATGGAGGAATTTGTACAGA	0.393000													7	794					0	0	1	0	0
ZNF718	255403	broad.mit.edu	37	4	155937	155937	+	RNA	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:155937T>C	ENST00000510175.1	+	0	1372							Q3SXZ3	ZN718_HUMAN	zinc finger protein 718						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		TGGGAGCCTTTAAGTCTTCCT	0.363000													9	58					0	0	1	0	0
SCN2A	6326	broad.mit.edu	37	2	166201075	166201075	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:166201075T>C	ENST00000375437.2	+	16	2863	c.2573T>C	c.(2572-2574)tTc>tCc	p.F858S	SCN2A_ENST00000283256.6_Missense_Mutation_p.F858S|SCN2A_ENST00000357398.3_Missense_Mutation_p.F858S|SCN2A_ENST00000375427.2_Missense_Mutation_p.F858S	NM_001040142.1	NP_001035232.1	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha subunit	858					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|liver(2)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	118					Lamotrigine(DB00555)	CTCCGAGTTTTCAAGTTGGCA	0.328000													35	219					0	0	1	0	0
LILRB4	0	broad.mit.edu	37	19	55175822	55175822	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:55175822C>T	ENST00000391736.1	+	6	856	c.541C>T	c.(541-543)Ccc>Tcc	p.P181S	LILRB4_ENST00000430952.2_Missense_Mutation_p.P181S|LILRB4_ENST00000391733.3_Missense_Mutation_p.P181S|LILRB4_ENST00000391734.3_Missense_Mutation_p.P181S|LILRB4_ENST00000270452.2_Missense_Mutation_p.P181S	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	181	Ig-like C2-type 2.					integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		GGCTGAATTCCCCATGAGTCC	0.597000													136	217					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67066340	67066340	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:67066340C>A	ENST00000315962.4	+	9	1668	c.1295C>A	c.(1294-1296)gCa>gAa	p.A432E	TRIM55_ENST00000353317.5_Intron|TRIM55_ENST00000276573.7_Missense_Mutation_p.A432E|TRIM55_ENST00000350034.4_Intron	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	432						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CCAGTCCCTGCAGCAGCAGAA	0.493000													6	236					8.12818e-05	8.4735e-05	1	1	0
C20orf26	26074	broad.mit.edu	37	20	20278839	20278839	+	Silent	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:20278839A>G	ENST00000245957.5	+	25	3307	c.3231A>G	c.(3229-3231)gtA>gtG	p.V1077V	C20orf26_ENST00000377309.2_3'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	1077										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		TAGAACTAGTAACCGGCAGTG	0.403000													23	379					0	0	1	0	0
SLAMF1	6504	broad.mit.edu	37	1	160604452	160604452	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:160604452G>T	ENST00000302035.6	-	3	1000	c.651C>A	c.(649-651)aaC>aaA	p.N217K	SLAMF1_ENST00000235739.5_Missense_Mutation_p.N217K|SLAMF1_ENST00000538290.1_Missense_Mutation_p.N217K|SLAMF1_ENST00000355199.3_Missense_Mutation_p.N217K	NM_003037.2	NP_003028.1	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family member 1	217	Ig-like C2-type.				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TCTGGGAATTGTTGCTGATAG	0.592000													8	284					0.00448238	0.00459768	1	1	0
TRIOBP	11078	broad.mit.edu	37	22	38120694	38120694	+	Missense_Mutation	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:38120694C>G	ENST00000406386.3	+	7	2386	c.2131C>G	c.(2131-2133)Cct>Gct	p.P711A	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	711					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AGCCTCCTCTCCTAACAGAAC	0.582000													7	515					0	0	1	0	0
SH2D2A	9047	broad.mit.edu	37	1	156777073	156777073	+	Missense_Mutation	SNP	T	T	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:156777073T>G	ENST00000392306.2	-	8	1236	c.1097A>C	c.(1096-1098)cAc>cCc	p.H366P	SH2D2A_ENST00000368199.3_Missense_Mutation_p.H356P|SH2D2A_ENST00000368198.3_Missense_Mutation_p.H338P	NM_001161441.1	NP_001154913.1	Q9NP31	SH22A_HUMAN	SH2 domain containing 2A	356	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|large_intestine(2)|lung(15)	18	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGGGGGCTGGTGGGGCAGGGG	0.597000													6	37					0	0	1	0	0
UBE3C	9690	broad.mit.edu	37	7	156963025	156963025	+	Missense_Mutation	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:156963025C>G	ENST00000348165.5	+	4	583	c.223C>G	c.(223-225)Cgc>Ggc	p.R75G	UBE3C_ENST00000389103.4_Missense_Mutation_p.R32G	NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	75					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		TGCATTTGATCGCTGTGCTAC	0.388000													461	392					0	0	1	0	0
OCRL	4952	broad.mit.edu	37	X	128721077	128721077	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chrX:128721077C>T	ENST00000371113.4	+	20	2403	c.2238C>T	c.(2236-2238)ttC>ttT	p.F746F	OCRL_ENST00000357121.5_Silent_p.F738F	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	746	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						ATCACCTATTCAAATACGCCT	0.468000													8	509					0	0	1	0	0
SMG6	23293	broad.mit.edu	37	17	2195869	2195869	+	Silent	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:2195869A>G	ENST00000544865.1	-	6	2731	c.2221T>C	c.(2221-2223)Ttg>Ctg	p.L741L	SMG6_ENST00000263073.5_Silent_p.L772L			Q86US8	EST1A_HUMAN	SMG6 nonsense mediated mRNA decay factor	772					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(10)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						AGCAAAGCCAACTGGTTATAG	0.438000													8	785					0	0	1	0	0
PRPF38B	55119	broad.mit.edu	37	1	109242415	109242415	+	Silent	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:109242415C>A	ENST00000370021.1	+	7	1718	c.1081C>A	c.(1081-1083)Cga>Aga	p.R361R	PRPF38B_ENST00000370025.4_Silent_p.R472R			Q5VTL8	PR38B_HUMAN	pre-mRNA processing factor 38B	472	Arg-rich.				mRNA processing|RNA splicing	spliceosomal complex				NS(1)|kidney(3)|large_intestine(5)|lung(8)|prostate(1)|skin(1)	19		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0149)|Lung(183;0.0888)|COAD - Colon adenocarcinoma(174;0.113)|Epithelial(280;0.161)		TAAACGAAGTCGAAGTGGCAG	0.353000													42	432					3.54561e-26	4.02508e-26	1	1	0
CCDC146	57639	broad.mit.edu	37	7	76885756	76885756	+	Missense_Mutation	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:76885756C>G	ENST00000285871.4	+	6	741	c.614C>G	c.(613-615)tCt>tGt	p.S205C	AC073635.5_ENST00000476561.2_RNA|CCDC146_ENST00000431197.1_5'UTR	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	205										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				GATTTGGCATCTAAACAAAAG	0.318000													6	268					0	0	1	0	0
NKG7	4818	broad.mit.edu	37	19	51875040	51875040	+	Missense_Mutation	SNP	T	T	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:51875040T>A	ENST00000221978.5	-	4	668	c.489A>T	c.(487-489)gaA>gaT	p.E163D	NKG7_ENST00000595217.1_3'UTR|NKG7_ENST00000600427.1_Missense_Mutation_p.E83D	NM_005601.3	NP_005592.1	Q16617	NKG7_HUMAN	natural killer cell group 7 sequence	163						integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000211)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CTCACAAGGTTTCATAGCCAG	0.582000													87	1095					0	0	1	0	0
WDR70	55100	broad.mit.edu	37	5	37725121	37725121	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:37725121G>A	ENST00000265107.4	+	16	1839	c.1683G>A	c.(1681-1683)tcG>tcA	p.S561S		NM_018034.2	NP_060504.1	Q9NW82	WDR70_HUMAN	WD repeat domain 70	561										central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCCTGAAGTCGCATAAACCTG	0.527000													7	676					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211517	78211517	+	RNA	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:78211517C>G	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							TTGCTCAGGACACTCAAGGCC	0.557000													5	761					0	0	1	0	0
OR1A2	26189	broad.mit.edu	37	17	3101038	3101038	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:3101038G>A	ENST00000381951.1	+	1	226	c.226G>A	c.(226-228)Gta>Ata	p.V76I		NM_012352.1	NP_036484.1	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A, member 2	76					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V76I(1)		breast(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(4)|stomach(2)	18						CTTCTCATCCGTAACCATCCC	0.488000													8	780					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141298554	141298554	+	Missense_Mutation	SNP	T	T	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:141298554T>G	ENST00000389484.3	-	45	8472	c.7501A>C	c.(7501-7503)Aac>Cac	p.N2501H		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2501					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACACATCTGTTGTCCTCTAGC	0.398000										TSP Lung(27;0.18)			42	346					0	0	1	0	0
SHISA3	152573	broad.mit.edu	37	4	42403193	42403193	+	Missense_Mutation	SNP	A	A	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:42403193A>C	ENST00000319234.4	+	2	660	c.442A>C	c.(442-444)Atg>Ctg	p.M148L		NM_001080505.1	NP_001073974.1	A0PJX4	SHSA3_HUMAN	shisa family member 3	148					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	12						GACCCTGCCCATGATCCTGAC	0.607000													8	1331					0	0	1	0	0
CNDP1	84735	broad.mit.edu	37	18	72228134	72228134	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr18:72228134C>A	ENST00000582365.1	+	3	284	c.218C>A	c.(217-219)gCc>gAc	p.A73D	CNDP1_ENST00000358821.3_Missense_Mutation_p.A116D|CNDP1_ENST00000585136.1_Intron			Q96KN2	CNDP1_HUMAN	carnosine dipeptidase 1 (metallopeptidase M20 family)	116					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		ATCATCCTGGCCGAACTGGGG	0.547000													9	545					2.80697e-09	3.02508e-09	1	1	0
ITCH	83737	broad.mit.edu	37	20	33045269	33045269	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:33045269A>G	ENST00000374864.4	+	13	1498	c.1285A>G	c.(1285-1287)Aga>Gga	p.R429G	ITCH_ENST00000262650.6_Missense_Mutation_p.R470G|ITCH_ENST00000483727.1_3'UTR|ITCH_ENST00000535650.1_Missense_Mutation_p.R319G	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	470	Required for interaction with FYN.				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						GGAAGACCCCAGAAGTCAAGG	0.388000													10	207					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23887583	23887583	+	Silent	SNP	C	C	T	rs144465613	byFrequency	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr14:23887583C>T	ENST00000355349.3	-	30	4167	c.4005G>A	c.(4003-4005)tcG>tcA	p.S1335S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1335					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.S1335S(3)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CATGCCGGGCCGACTGCAGTG	0.662000													14	198					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152330000	152330000	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:152330000C>T	ENST00000388718.5	-	3	334	c.262G>A	c.(262-264)Gtc>Atc	p.V88I	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	88							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGCTGAGGACCTTGTTGCAG	0.438000													93	77					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12124753	12124753	+	Silent	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:12124753T>C	ENST00000379388.2	+	4	5057	c.4725T>C	c.(4723-4725)tcT>tcC	p.S1575S		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	1575					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CTTGCTCTTCTAATCCTGTGC	0.383000													31	483					0	0	1	0	0
HSPA12B	116835	broad.mit.edu	37	20	3721480	3721480	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:3721480C>T	ENST00000254963.2	+	3	207	c.62C>T	c.(61-63)tCc>tTc	p.S21F	HSPA12B_ENST00000542646.1_Intron	NM_001197327.1|NM_052970.4	NP_001184256.1|NP_443202.3	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	21							ATP binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	14						CCGGAGCGGTCCCCAGTGCCT	0.662000													13	115					0	0	1	0	0
SIGIRR	59307	broad.mit.edu	37	11	408737	408737	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:408737G>A	ENST00000431843.2	-	3	470	c.164C>T	c.(163-165)cCa>cTa	p.P55L	SIGIRR_ENST00000382520.2_Missense_Mutation_p.P55L|SIGIRR_ENST00000332725.3_Missense_Mutation_p.P55L|SIGIRR_ENST00000397632.3_Missense_Mutation_p.P55L|SIGIRR_ENST00000531205.1_Missense_Mutation_p.P55L|SIGIRR_ENST00000529486.1_Intron	NM_001135054.1	NP_001128526.1	Q6IA17	SIGIR_HUMAN	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	55	Ig-like C2-type.				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity			cervix(2)|endometrium(1)|liver(1)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	13		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AATTCCCAATGGAAGCCCGTC	0.607000													220	703					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234788	21234788	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:21234788C>T	ENST00000233242.1	-	26	5079	c.4952G>A	c.(4951-4953)gGa>gAa	p.G1651E		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1651					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GGTAGATATTCCATCTTGGCC	0.448000													9	217					0	0	1	0	0
NEIL3	55247	broad.mit.edu	37	4	178257339	178257339	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:178257339G>T	ENST00000264596.3	+	4	609	c.491G>T	c.(490-492)aGa>aTa	p.R164I		NM_018248.2	NP_060718.2	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3 (E. coli)	164					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		AGTTTCTTGAGAGCAGAAAGT	0.358000								Base excision repair (BER), DNA glycosylases					7	277					0.27861	0.27861	1	1	0
PRSS3P2	0	broad.mit.edu	37	7	142482242	142482242	+	RNA	SNP	G	G	A	rs143538588	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:142482242G>A	ENST00000603901.1	+	0	622					NR_001296.3																						GGTCTGCAATGGACAGCTTCA	0.493000													5	80					0	0	1	0	0
SALL4	57167	broad.mit.edu	37	20	50406795	50406795	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:50406795G>T	ENST00000217086.4	-	2	2338	c.2227C>A	c.(2227-2229)Ctg>Atg	p.L743M	SALL4_ENST00000395997.3_Intron|SALL4_ENST00000371539.3_Intron	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	743					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TGGCGCTGCAGGTTAAAAGGG	0.587000													6	249					0.0215528	0.0220363	1	1	0
ACVR1C	130399	broad.mit.edu	37	2	158397669	158397669	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:158397669G>T	ENST00000243349.7	-	7	1518	c.1158C>A	c.(1156-1158)ttC>ttA	p.F386L	ACVR1C_ENST00000348328.5_Missense_Mutation_p.F229L|ACVR1C_ENST00000409680.3_Missense_Mutation_p.F336L|ACVR1C_ENST00000335450.7_Missense_Mutation_p.F306L	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	386	Protein kinase.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						CAGCTCGTTTGAAGGACTCAA	0.378000													19	435					1.40151e-16	1.54166e-16	1	1	0
DMBX1	127343	broad.mit.edu	37	1	46977796	46977796	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:46977796C>A	ENST00000371956.4	+	4	794	c.779C>A	c.(778-780)cCg>cAg	p.P260Q	DMBX1_ENST00000360032.3_Missense_Mutation_p.P255Q	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	260					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					TCCTCGTCCCCGCTGAGCCTC	0.642000													8	653					5.18039e-06	5.49018e-06	1	1	0
CLEC12B	387837	broad.mit.edu	37	12	10167245	10167245	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:10167245A>G	ENST00000396502.1	+	3	442	c.314A>G	c.(313-315)gAg>gGg	p.E105G	CLEC12B_ENST00000338896.5_Missense_Mutation_p.E105G	NM_205852.2	NP_995324.2	Q2HXU8	CL12B_HUMAN	C-type lectin domain family 12, member B	105						integral to membrane|plasma membrane	receptor activity|sugar binding			central_nervous_system(2)|large_intestine(2)|lung(5)	9						TTGTCCATGGAGGAGGAATTT	0.433000													31	176					0	0	1	0	0
TOR4A	54863	broad.mit.edu	37	9	140173477	140173477	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:140173477C>T	ENST00000357503.2	+	2	532	c.336C>T	c.(334-336)cgC>cgT	p.R112R		NM_017723.2	NP_060193.2	Q9NXH8	CI167_HUMAN	torsin family 4, member A	112					chaperone mediated protein folding requiring cofactor	integral to membrane	ATP binding|nucleoside-triphosphatase activity										ATCGGCCGCGCGTGGAGCACA	0.667000													4	52					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G|EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													7	311					0	0	1	0	0
SDE2	163859	broad.mit.edu	37	1	226175604	226175604	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:226175604C>T	ENST00000272091.7	-	6	1145	c.1127G>A	c.(1126-1128)gGa>gAa	p.G376E	SDE2_ENST00000366817.1_Missense_Mutation_p.G281E	NM_152608.3	NP_689821.3			SDE2 telomere maintenance homolog (S. pombe)																		TACTGCGTTTCCTGGCTGGCT	0.443000													27	265					0	0	1	0	0
CUL1	8454	broad.mit.edu	37	7	148457556	148457556	+	Missense_Mutation	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:148457556C>G	ENST00000325222.4	+	7	1036	c.757C>G	c.(757-759)Cag>Gag	p.Q253E	CUL1_ENST00000602748.1_Missense_Mutation_p.Q253E|CUL1_ENST00000409469.1_Missense_Mutation_p.Q253E	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	253					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TGAATTCTTGCAGCAGAACCC	0.343000													7	1273					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													8	183					0	0	1	0	0
RANBP3	8498	broad.mit.edu	37	19	5923907	5923907	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:5923907C>T	ENST00000340578.6	-	12	1072	c.1015G>A	c.(1015-1017)Gag>Aag	p.E339K	RANBP3_ENST00000541471.1_Missense_Mutation_p.E211K|RANBP3_ENST00000034275.8_Missense_Mutation_p.E271K|RANBP3_ENST00000439268.2_Missense_Mutation_p.E334K|RANBP3_ENST00000591092.1_Missense_Mutation_p.E266K	NM_003624.2|NM_007320.2|NM_007322.2	NP_003615.2|NP_015559.2|NP_015561.1	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3	339					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	18						GAACTGACCTCGTTTAATTTT	0.562000													36	230					0	0	1	0	0
ABHD3	171586	broad.mit.edu	37	18	19283559	19283559	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr18:19283559C>T	ENST00000289119.2	-	2	451	c.312G>A	c.(310-312)ccG>ccA	p.P104P	ABHD3_ENST00000580981.1_Silent_p.P104P|ABHD3_ENST00000578270.1_5'UTR|ABHD3_ENST00000579875.1_5'UTR	NM_138340.4	NP_612213.2	Q8WU67	ABHD3_HUMAN	abhydrolase domain containing 3	104						integral to membrane	carboxylesterase activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|prostate(2)	10						TGTACTGCACCGGGGGCTTCG	0.483000													229	186					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4735395	4735395	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:4735395C>T	ENST00000354582.6	+	33	4601	c.4251C>T	c.(4249-4251)cgC>cgT	p.R1417R	ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000456211.2_Silent_p.R1393R|ITPR1_ENST00000443694.2_Silent_p.R1402R|ITPR1_ENST00000423119.2_Silent_p.R1408R|ITPR1_ENST00000357086.4_Silent_p.R1408R|ITPR1_ENST00000302640.8_Silent_p.R1402R			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	1417					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		ACATCGTTCGCGTGGTGACCC	0.592000													10	81					0	0	1	0	0
TIGD5	84948	broad.mit.edu	37	8	144681772	144681772	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:144681772G>A	ENST00000504548.2	+	1	1699	c.1699G>A	c.(1699-1701)Gcc>Acc	p.A567T	TIGD5_ENST00000321385.3_Missense_Mutation_p.A518T	NM_032862.4	NP_116251.4	E7EWS2	E7EWS2_HUMAN	tigger transposable element derived 5	567					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding			NS(1)|lung(3)|ovary(1)|soft_tissue(1)|urinary_tract(1)	7	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			TCTGCCCTCTGCCATGGGGGG	0.726000													16	30					0	0	1	0	0
AC024560.3	0	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	T	C	rs138265355	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:197348646T>C	ENST00000418868.1	-	0	613					NR_003266.2																						TGGGCCTGCCTGCCCTTTCCA	0.532000													10	223					0	0	1	0	0
ACTL7B	10880	broad.mit.edu	37	9	111618120	111618120	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:111618120G>A	ENST00000374667.3	-	1	1119	c.91C>T	c.(91-93)Cgg>Tgg	p.R31W		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	31						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						CCTGTGTCCCGGAGGCTGGCG	0.652000													6	343					0	0	1	0	0
ARL17A	51326	broad.mit.edu	37	17	44594556	44594556	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:44594556G>A	ENST00000337845.7	-	5	707	c.569C>T	c.(568-570)gCg>gTg	p.A190V	LRRC37A2_ENST00000333412.3_Intron|LRRC37A2_ENST00000576629.1_Intron|ARL17A_ENST00000445552.2_Silent_p.C101C|ARL17A_ENST00000329240.4_Silent_p.C101C			Q8IVW1	ARL17_HUMAN	ADP-ribosylation factor-like 17A	0					protein transport|vesicle-mediated transport	Golgi apparatus	GTP binding			lung(1)	1						CGGTGACCCCGCATAATTTCT	0.413000													7	774					0	0	1	0	0
SLC35G5	83650	broad.mit.edu	37	8	11189622	11189622	+	Missense_Mutation	SNP	T	T	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:11189622T>A	ENST00000382435.4	+	1	1226	c.1007T>A	c.(1006-1008)gTg>gAg	p.V336E		NM_054028.1	NP_473369.1	Q96KT7	AMCL2_HUMAN	solute carrier family 35, member G5	336						integral to membrane											ACAGGGAAGGTGGAGGAGTGA	0.483000													76	194					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612452	20612452	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr14:20612452G>A	ENST00000333629.1	+	1	558	c.558G>A	c.(556-558)aaG>aaA	p.K186K		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		AGGTCATCAAGCTGGCCTGCA	0.522000													252	168					0	0	1	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104245101	104245101	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr14:104245101T>C	ENST00000202556.9	-	4	617	c.335A>G	c.(334-336)gAa>gGa	p.E112G		NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	112				E -> D (in Ref. 1; CAC83011).	apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				AGTACGTTTTTCTCCAGGTAC	0.388000													37	298					0	0	1	0	0
PPIF	10105	broad.mit.edu	37	10	81111297	81111297	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr10:81111297C>T	ENST00000225174.3	+	4	441	c.370C>T	c.(370-372)Cgc>Tgc	p.R124C	PPIF_ENST00000394579.3_Missense_Mutation_p.R124C	NM_005729.3	NP_005720.1	P30405	PPIF_HUMAN	peptidylprolyl isomerase F	124	PPIase cyclophilin-type.				protein folding	membrane fraction|mitochondrial matrix	peptidyl-prolyl cis-trans isomerase activity			endometrium(2)|lung(2)|skin(2)	6	all_cancers(46;0.0893)|Breast(12;8.52e-05)|all_epithelial(25;0.00449)|Prostate(51;0.00985)		Epithelial(14;0.00242)|all cancers(16;0.0069)|Colorectal(32;0.229)		Dimethyl sulfoxide(DB01093)|L-Proline(DB00172)	CTACGGAAGCCGCTTTCCTGA	0.607000													54	92					0	0	1	0	0
LRMP	4033	broad.mit.edu	37	12	25232196	25232196	+	Missense_Mutation	SNP	G	G	A	rs143325687	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:25232196G>A	ENST00000354454.3	+	6	872	c.43G>A	c.(43-45)Gtg>Atg	p.V15M	LRMP_ENST00000548766.1_Missense_Mutation_p.V15M|LRMP_ENST00000547044.1_Missense_Mutation_p.V15M	NM_006152.3	NP_006143.2	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	71					vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					TGTTGAACGCGTGTGTCCTGA	0.373000													48	398					0	0	1	0	0
OR10R2	343406	broad.mit.edu	37	1	158449944	158449944	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:158449944T>C	ENST00000368152.1	+	1	277	c.277T>C	c.(277-279)Tac>Cac	p.Y93H	RP11-144L1.4_ENST00000419738.1_RNA|RP11-144L1.4_ENST00000426251.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					TGAGACCTTCTACACCTTTGT	0.438000													69	608					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085442	9085442	+	Missense_Mutation	SNP	C	C	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:9085442C>A	ENST00000397910.4	-	1	6576	c.6373G>T	c.(6373-6375)Gca>Tca	p.A2125S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2125	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ACCGAGGATGCATCAGTGTTC	0.488000													193	377					4.54062e-68	5.24804e-68	1	1	0
POLR3B	55703	broad.mit.edu	37	12	106820975	106820975	+	Splice_Site	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:106820975C>T	ENST00000228347.4	+	13	1324	c.1101_splice	c.e13-1	p.L368_splice	POLR3B_ENST00000549195.1_3'UTR|POLR3B_ENST00000539066.1_Splice_Site_p.L310_splice	NM_018082.5	NP_060552.4	Q9NW08	RPC2_HUMAN	polymerase (RNA) III (DNA directed) polypeptide B	368					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding	p.L368F(4)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(14)|lung(22)|ovary(1)|prostate(3)|skin(3)|urinary_tract(2)	57						TTTTTTTTAGCTTTTATCTCT	0.274000													7	42					0	0	1	0	0
TM9SF2	9375	broad.mit.edu	37	13	100169875	100169875	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr13:100169875T>C	ENST00000376387.4	+	2	369	c.179T>C	c.(178-180)aTa>aCa	p.I60T	TM9SF2_ENST00000463709.1_3'UTR	NM_004800.1	NP_004791.1	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2	60					transport	endosome membrane|integral to plasma membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)	17	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					CAGGCCGAAATAGAACTATTT	0.313000													5	284					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63915945	63915945	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:63915945G>A	ENST00000443617.2	-	73	13677	c.13590C>T	c.(13588-13590)gaC>gaT	p.D4530D		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4530	HECT.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CTGTGATGGTGTCATCAAACA	0.512000													9	747					0	0	1	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617958	111617958	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:111617958C>T	ENST00000374667.3	-	1	1281	c.253G>A	c.(253-255)Gag>Aag	p.E85K		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	85						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TCGGCCGCCTCGGGGCAGCGT	0.652000													52	333					0	0	1	0	0
ACE2	59272	broad.mit.edu	37	X	15603621	15603621	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chrX:15603621C>T	ENST00000427411.1	-	8	1093	c.877G>A	c.(877-879)Gtt>Att	p.V293I	ACE2_ENST00000252519.3_Missense_Mutation_p.V293I	NM_021804.2	NP_068576.1	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2	293					angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	32	Hepatocellular(33;0.183)				Moexipril(DB00691)	GCATCAGTAACATCTATGTTT	0.323000													29	604					0	0	1	0	0
HSP90AB2P	0	broad.mit.edu	37	4	13339134	13339134	+	RNA	SNP	G	G	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:13339134G>C	ENST00000602906.1	+	0	862																				kidney(3)|lung(1)	4						TCATCTTTTTGAGAACAAGAA	0.428000													26	310					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29346935	29346935	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:29346935C>T	ENST00000558402.1	+	5	1447	c.848C>T	c.(847-849)tCg>tTg	p.S283L	APBA2_ENST00000561069.1_Missense_Mutation_p.S283L|APBA2_ENST00000411764.1_Missense_Mutation_p.S283L|APBA2_ENST00000558259.1_Missense_Mutation_p.S283L|APBA2_ENST00000558330.1_Missense_Mutation_p.S283L			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	283					nervous system development|protein transport		protein binding	p.S283L(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		AGGCCCAAGTCGCTGAACCTC	0.672000													13	72					0	0	1	0	0
RGPD1	400966	broad.mit.edu	37	2	87140987	87140987	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:87140987G>A	ENST00000398193.3	+	1	53	c.15G>A	c.(13-15)aaG>aaA	p.K5K	RGPD1_ENST00000409776.2_Intron			Q68DN6	RGPD1_HUMAN	RANBP2-like and GRIP domain containing 1	0					intracellular transport		binding			breast(1)|endometrium(1)|lung(1)	3						GGCGCAGCAAGGCCTACGGGG	0.672000													4	104					0	0	1	0	0
STAP1	26228	broad.mit.edu	37	4	68436828	68436828	+	Missense_Mutation	SNP	G	G	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:68436828G>T	ENST00000265404.2	+	2	229	c.147G>T	c.(145-147)ttG>ttT	p.L49F	STAP1_ENST00000396225.1_Missense_Mutation_p.L49F	NM_012108.2	NP_036240.1	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	49	PH.				cellular membrane fusion|intracellular protein transport	cytoplasm				NS(1)|large_intestine(1)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	12						GGACAGAGTTGAGAGGAACTA	0.308000													65	805					3.37205e-40	3.86937e-40	1	1	0
DNM1P47	0	broad.mit.edu	37	15	102303120	102303120	+	RNA	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:102303120C>G	ENST00000561463.1	+	0	11166																											CTTCTCAGAGCTGCTGTCCAA	0.592000													6	207					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37465248	37465248	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:37465248C>T	ENST00000381792.2	-	16	2118	c.1978G>A	c.(1978-1980)Gtg>Atg	p.V660M	TMPRSS6_ENST00000406725.1_Missense_Mutation_p.V660M|TMPRSS6_ENST00000406856.1_Missense_Mutation_p.V660M|TMPRSS6_ENST00000346753.3_Missense_Mutation_p.V669M			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	669	Peptidase S1.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						AGCAGCGCCACGTCGTAGTCA	0.692000													18	60					0	0	1	0	0
TUBA3E	112714	broad.mit.edu	37	2	130951720	130951720	+	Missense_Mutation	SNP	C	C	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:130951720C>G	ENST00000312988.7	-	4	795	c.695G>C	c.(694-696)gGg>gCg	p.G232A		NM_207312.2	NP_997195.1	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	232					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(4)|kidney(7)|large_intestine(6)|lung(9)|skin(2)	28	Colorectal(110;0.1)					CACGATCTGCCCAATCAGGCG	0.557000													17	730					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144075960	144075960	+	Splice_Site	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:144075960G>A	ENST00000056217.5	+	14	4810		c.e14+1		ARHGEF5_ENST00000471847.2_Splice_Site	NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5						intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					AGCAGTGACGGTAAGCGGGAG	0.587000													7	622					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107866732	107866732	+	Missense_Mutation	SNP	T	T	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:107866732T>C	ENST00000379028.3	-	9	1111	c.641A>G	c.(640-642)gAa>gGa	p.E214G	NRCAM_ENST00000351718.4_Missense_Mutation_p.E208G|NRCAM_ENST00000413765.2_Missense_Mutation_p.E214G|NRCAM_ENST00000379022.4_Missense_Mutation_p.E214G|NRCAM_ENST00000379024.4_Missense_Mutation_p.E214G|NRCAM_ENST00000425651.2_Missense_Mutation_p.E214G			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	214	Ig-like 2.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						GATATAGTCTTCGCGGGTGTC	0.418000													65	456					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18703434	18703434	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:18703434C>T	ENST00000251296.1	+	8	1625	c.1242C>T	c.(1240-1242)acC>acT	p.T414T		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	414	Ig-like 2.					extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		ATCGCTGCACCGCCCAGAACC	0.657000													13	206					0	0	1	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172584337	172584337	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:172584337G>A	ENST00000534253.2	+	12	1171	c.1003G>A	c.(1003-1005)Gtg>Atg	p.V335M	DYNC1I2_ENST00000409317.1_Missense_Mutation_p.V329M|DYNC1I2_ENST00000358002.6_Missense_Mutation_p.V327M|DYNC1I2_ENST00000340296.4_Missense_Mutation_p.V309M|DYNC1I2_ENST00000409773.1_Missense_Mutation_p.V335M|DYNC1I2_ENST00000397119.3_Missense_Mutation_p.V335M|DYNC1I2_ENST00000410079.3_Missense_Mutation_p.V327M|DYNC1I2_ENST00000508530.1_Missense_Mutation_p.V309M|DYNC1I2_ENST00000409453.1_Missense_Mutation_p.V335M|DYNC1I2_ENST00000263811.4_Missense_Mutation_p.V329M|DYNC1I2_ENST00000409197.1_Missense_Mutation_p.V309M			Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	335					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			GCAGTCAGCTGTGATGTCTGC	0.338000													67	71					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16040288	16040288	+	Missense_Mutation	SNP	G	G	A	rs138578304		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:16040288G>A	ENST00000326742.7	-	2	323	c.322C>T	c.(322-324)Cgg>Tgg	p.R108W	CYP4F11_ENST00000402119.3_Missense_Mutation_p.R108W|CYP4F11_ENST00000248041.7_Missense_Mutation_p.R108W			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	108					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						GTGATAGGCCGGATAATGTCA	0.557000													6	684					0	0	1	0	0
ANKRD27	84079	broad.mit.edu	37	19	33089124	33089124	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:33089124G>A	ENST00000306065.4	-	29	3238	c.3080C>T	c.(3079-3081)gCg>gTg	p.A1027V		NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	1027					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity	p.A1027V(1)		breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					GGACACGACCGCATCCTCTAC	0.617000													6	757					0	0	1	0	0
CTAG2	30848	broad.mit.edu	37	X	153880703	153880703	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chrX:153880703C>T	ENST00000247306.4	-	2	535	c.472G>A	c.(472-474)Gcc>Acc	p.A158T	CTAG2_ENST00000369585.3_Intron	NM_020994.3	NP_066274.1	O75638	CTAG2_HUMAN	cancer/testis antigen 2	158						centrosome				central_nervous_system(1)|endometrium(1)|lung(6)|ovary(1)|pancreas(1)	10	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TCCGGGGAGGCGGATCCCAGC	0.627000													50	574					0	0	1	0	0
CCDC64B	146439	broad.mit.edu	37	16	3079353	3079353	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr16:3079353C>T	ENST00000573514.1	-	5	2604	c.414G>A	c.(412-414)aaG>aaA	p.K138K	CCDC64B_ENST00000389347.4_Silent_p.K345K|CCDC64B_ENST00000572449.1_Silent_p.K345K			A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	345										breast(1)|endometrium(2)|large_intestine(1)	4						ATGTTCGCTTCTTGGGGGGCT	0.607000													4	67					0	0	1	0	0
RRP8	23378	broad.mit.edu	37	11	6622651	6622651	+	Silent	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:6622651G>A	ENST00000254605.6	-	3	762	c.645C>T	c.(643-645)gcC>gcT	p.A215A	RRP8_ENST00000534343.1_Intron	NM_015324.3	NP_056139.1	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase, homolog (yeast)	215					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)	13						TCTCTGTGGGGGCCTCAGCTG	0.602000													19	194					0	0	1	0	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000539936.1_3'UTR|AQP7_ENST00000377425.4_Intron|AQP7_ENST00000537089.1_3'UTR			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													6	330					0	0	1	0	0
FIG4	9896	broad.mit.edu	37	6	110146342	110146342	+	Silent	SNP	A	A	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:110146342A>C	ENST00000230124.3	+	23	2722	c.2598A>C	c.(2596-2598)ccA>ccC	p.P866P	FIG4_ENST00000441478.2_Silent_p.P560P	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	866					cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		TTCAGCCCCCAAGAGTAGACA	0.448000													64	563					0	0	1	0	0
THBS4	7060	broad.mit.edu	37	5	79351673	79351673	+	Missense_Mutation	SNP	G	G	A			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:79351673G>A	ENST00000350881.2	+	3	548	c.358G>A	c.(358-360)Gca>Aca	p.A120T	CTD-2201I18.1_ENST00000503007.1_RNA|THBS4_ENST00000511733.1_Missense_Mutation_p.A29T	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	120	TSP N-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		CCTGCAGCTGGCAGACGGAAG	0.562000													5	546					0	0	1	0	0
IL27RA	9466	broad.mit.edu	37	19	14150430	14150430	+	Missense_Mutation	SNP	C	C	A	rs145198960		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:14150430C>A	ENST00000263379.2	+	3	454	c.329C>A	c.(328-330)gCa>gAa	p.A110E		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	110					cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						GGCACTAAGGCAGGCCAGCCT	0.617000													41	313					5.20837e-25	5.89174e-25	1	1	0
MYO1E	4643	broad.mit.edu	37	15	59519753	59519753	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:59519753C>T	ENST00000288235.4	-	7	946	c.547G>A	c.(547-549)Gaa>Aaa	p.E183K	MYO1E_ENST00000558814.1_5'UTR	NM_004998.3	NP_004989.2	Q12965	MYO1E_HUMAN	myosin IE	183	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(6)|lung(10)|pancreas(2)|prostate(1)|urinary_tract(1)	33				all cancers(107;0.207)		CCATCTGGTTCCCCACCTGGA	0.438000													40	446					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49698770	49698770	+	Silent	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:49698770C>T	ENST00000296452.4	+	6	9606	c.9492C>T	c.(9490-9492)atC>atT	p.I3164I		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	3164					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		ATGAGGTGATCGCCAGCCCCG	0.607000													8	241					0	0	1	0	0
DENND1A	57706	broad.mit.edu	37	9	126164112	126164112	+	Missense_Mutation	SNP	C	C	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:126164112C>T	ENST00000373620.3	-	21	1877	c.1657G>A	c.(1657-1659)Ggc>Agc	p.G553S	DENND1A_ENST00000473039.1_Intron|DENND1A_ENST00000542603.1_Intron|DENND1A_ENST00000373624.2_Intron|DENND1A_ENST00000394219.3_Intron|DENND1A_ENST00000394215.2_Missense_Mutation_p.G523S	NM_024820.2	NP_079096.2	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	0						cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						GAGGTCCAGCCTCTCGTCGGG	0.498000											OREG0019470	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	353					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4772583	4772585	+	In_Frame_Del	DEL	CCA	CCA	-	rs141981296	byFrequency	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:4772583_4772585delCCA	ENST00000378191.4	+	2	1034_1036	c.653_655delCCA	c.(652-657)gcc>g	p.AT218del	AJAP1_ENST00000378190.3_In_Frame_Del_p.AT218del	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	218	Thr-rich.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane		p.T225_A226insT(1)		endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		ACTGTGGccgccaccaccaccac	0.635													9	105	---	---	---	---					
PLEKHG5	57449	broad.mit.edu	37	1	6536011	6536013	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:6536011_6536013delCTC	ENST00000377748.1	-	4	855_857	c.358_360delGAG	c.(358-360)del	p.E120del	PLEKHG5_ENST00000400915.3_In_Frame_Del_p.E99del|PLEKHG5_ENST00000535355.1_In_Frame_Del_p.E112del|PLEKHG5_ENST00000377732.1_In_Frame_Del_p.E80del|PLEKHG5_ENST00000400913.1_In_Frame_Del_p.E43del|PLEKHG5_ENST00000377725.1_In_Frame_Del_p.E43del|PLEKHG5_ENST00000377728.3_In_Frame_Del_p.E43del|PLEKHG5_ENST00000544978.1_In_Frame_Del_p.E43del|PLEKHG5_ENST00000537245.1_In_Frame_Del_p.E122del|PLEKHG5_ENST00000377740.3_In_Frame_Del_p.E120del|PLEKHG5_ENST00000377737.2_In_Frame_Del_p.E43del|PLEKHG5_ENST00000340850.5_In_Frame_Del_p.E43del	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	99					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CCACAGAGCTCTCCTCCTCCTCC	0.631											OREG0013041	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	535	---	---	---	---					
RP11-343N15.1	0	broad.mit.edu	37	1	121137791	121137793	+	RNA	DEL	CCA	CCA	-	rs28552466	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:121137791_121137793delCCA	ENST00000437515.1	-	0	329																											ATTTCGCCCTCCACCGCCGCCGC	0.631													13	50	---	---	---	---					
CENPF	1063	broad.mit.edu	37	1	214818826	214818826	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr1:214818826delA	ENST00000366955.3	+	13	6081	c.5913delA	c.(5911-5913)tcfs	p.S1971fs		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2067					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		ATACTATGTCAAAAAAAACCA	0.408													7	293	---	---	---	---					
EHBP1	23301	broad.mit.edu	37	2	63206352	63206353	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr2:63206352_63206353delGA	ENST00000263991.5	+	16	3077_3078	c.2595_2596delGA	c.(2593-2598)ctgafs	p.LR865fs	EHBP1_ENST00000354487.3_Frame_Shift_Del_p.LR830fs|EHBP1_ENST00000431489.1_Frame_Shift_Del_p.LR830fs|EHBP1_ENST00000496857.1_3'UTR|EHBP1_ENST00000405289.1_Frame_Shift_Del_p.LR830fs|EHBP1_ENST00000405015.3_Frame_Shift_Del_p.LR830fs	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	865						cytoplasm|membrane		p.R868fs*22(1)		biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			GTCGGCAGCTGAGAGAGAGAGC	0.426													8	307	---	---	---	---					
EDEM1	9695	broad.mit.edu	37	3	5248941	5248941	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:5248941delT	ENST00000256497.4	+	7	1454	c.1321delT	c.(1321-1323)ttfs	p.F442fs	EDEM1_ENST00000445686.1_Frame_Shift_Del_p.F247fs	NM_014674.2	NP_055489.1	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like 1	442					ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		TCTGCAGGCCTTTTTCCCTGG	0.463													10	621	---	---	---	---					
TMEM40	55287	broad.mit.edu	37	3	12790198	12790200	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:12790198_12790200delGAG	ENST00000314124.7	-	3	521_523	c.165_167delCTC	c.(163-168)tct>tc	p.SS69del	TMEM40_ENST00000435575.1_Intron|TMEM40_ENST00000264728.8_In_Frame_Del_p.SS69del|TMEM40_ENST00000435218.2_In_Frame_Del_p.SS69del|TMEM40_ENST00000431022.2_In_Frame_Del_p.SS85del	NM_018306.2	NP_060776.2	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	69	Ser-rich.					integral to membrane				breast(1)|large_intestine(3)|lung(5)|urinary_tract(1)	10						tgaggaggaagaggaggaggagg	0.419													8	735	---	---	---	---					
FAM86JP	0	broad.mit.edu	37	3	125647339	125647339	+	RNA	DEL	C	C	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr3:125647339delC	ENST00000485843.1	+	0	484					NR_024251.1																						TGTTTCCAGGCCAGGCCAGGA	0.557													9	375	---	---	---	---					
FGFRL1	53834	broad.mit.edu	37	4	1019055	1019056	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:1019055_1019056delCA	ENST00000398484.2	+	8	2015_2016	c.1435_1436delCA	c.(1435-1437)cfs	p.H479fs	FGFRL1_ENST00000504138.1_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000264748.6_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000510644.1_Frame_Shift_Del_p.H479fs			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	479	His-rich.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			cacagacatccacacacacaca	0.584													9	79	---	---	---	---					
FGFBP1	9982	broad.mit.edu	37	4	15938178	15938178	+	Frame_Shift_Del	DEL	T	T	-	rs144178676		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:15938178delT	ENST00000382333.1	-	3	372	c.78delA	c.(76-78)aafs	p.K26fs	FGFBP1_ENST00000259988.2_Frame_Shift_Del_p.K26fs	NM_005130.4	NP_005121.1	Q14512	FGFP1_HUMAN	fibroblast growth factor binding protein 1	26					cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|prostate(2)|skin(1)	10						CATTCTTCACTTTTTTTTTCC	0.527													15	681	---	---	---	---					
KIAA1211	57482	broad.mit.edu	37	4	57182265	57182267	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:57182265_57182267delAGA	ENST00000504228.1	+	6	2702_2704	c.2597_2599delAGA	c.(2596-2601)cag>c	p.QK866del	KIAA1211_ENST00000541073.1_In_Frame_Del_p.QK859del|KIAA1211_ENST00000264229.6_In_Frame_Del_p.QK866del			Q6ZU35	K1211_HUMAN	KIAA1211	866										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CAGGCAGAACAGAAGAAGAAGAA	0.567													8	394	---	---	---	---					
UTP3	57050	broad.mit.edu	37	4	71554620	71554622	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:71554620_71554622delGAG	ENST00000254803.2	+	1	425_427	c.226_228delGAG	c.(226-228)del	p.E81del		NM_020368.2	NP_065101.1	Q9NQZ2	SAS10_HUMAN	UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)	81	Glu-rich.				brain development|chromatin modification|gene silencing	nucleolus				endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(4)	18			Lung(101;0.235)			ggaggatggcgaggaggaggagg	0.567													7	159	---	---	---	---					
CDKL2	8999	broad.mit.edu	37	4	76539579	76539580	+	Frame_Shift_Ins	INS	-	-	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:76539579_76539580insT	ENST00000429927.2	-	3	925_926	c.222_223insA	c.(220-225)aagatgfs	p.M75fs	CDKL2_ENST00000307465.4_Frame_Shift_Ins_p.M75fs	NM_003948.3	NP_003939.1	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2 (CDC2-related kinase)	75	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(2)|stomach(2)	22			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			AGGTACCATCGTTTTTTTTTCT	0.322													10	378	---	---	---	---					
PKD2	5311	broad.mit.edu	37	4	88986559	88986559	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:88986559delA	ENST00000237596.2	+	11	2218	c.2152delA	c.(2152-2154)aafs	p.K719fs	PKD2_ENST00000511337.1_3'UTR|PKD2_ENST00000502363.1_Frame_Shift_Del_p.K137fs|PKD2_ENST00000508588.1_Frame_Shift_Del_p.K137fs	NM_000297.3	NP_000288.1	Q13563	PKD2_HUMAN	polycystic kidney disease 2 (autosomal dominant)	719	EF-hand domain.					basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(2)|lung(15)|skin(4)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		ACTAAAACTGAAAAAAAATAC	0.383													9	602	---	---	---	---					
SCLT1	132320	broad.mit.edu	37	4	129924994	129924995	+	Frame_Shift_Ins	INS	-	-	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr4:129924994_129924995insT	ENST00000281142.5	-	6	830_831	c.327_328insA	c.(325-330)aatggafs	p.NG109fs	SCLT1_ENST00000434680.1_Frame_Shift_Ins_p.NG109fs|SCLT1_ENST00000439369.2_Intron|SCLT1_ENST00000503215.1_Frame_Shift_Ins_p.NG86fs	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	109						centrosome				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						AAGGCCTCCAATTTTTTTTCAA	0.381													7	397	---	---	---	---					
PPARGC1B	133522	broad.mit.edu	37	5	149216400	149216402	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr5:149216400_149216402delCAG	ENST00000309241.5	+	8	2414_2416	c.2382_2384delCAG	c.(2380-2385)gac>ga	p.DS794del	PPARGC1B_ENST00000403750.1_In_Frame_Del_p.DS730del|PPARGC1B_ENST00000394320.3_In_Frame_Del_p.DS794del|PPARGC1B_ENST00000360453.4_In_Frame_Del_p.DS755del	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	794	Glu-rich.				estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity	p.S795N(1)		NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TCTTTGAAGACAGCAGCAGCAGC	0.601													12	483	---	---	---	---					
BTN2A3P	0	broad.mit.edu	37	6	26422388	26422390	+	RNA	DEL	CCT	CCT	-	rs113134648		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:26422388_26422390delCCT	ENST00000466808.2	+	0	42_44																											GGCCAGCCTCCCTCCTCCTCCTC	0.586													10	534	---	---	---	---					
GABBR1	0	broad.mit.edu	37	6	29573436	29573438	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:29573436_29573438delCAG	ENST00000377034.4	-	20	2682_2684	c.2347_2349delCTG	c.(2347-2349)del	p.L783del	GABBR1_ENST00000377016.4_In_Frame_Del_p.L721del|GABBR1_ENST00000355973.3_In_Frame_Del_p.L666del|GABBR1_ENST00000377012.4_In_Frame_Del_p.L666del|GABBR1_ENST00000376977.3_3'UTR	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	783					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity	p.L783M(1)		endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	GGAAGATTCCCAGCAGCAGCAGC	0.512													8	394	---	---	---	---					
PPP1R18	170954	broad.mit.edu	37	6	30653494	30653496	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:30653494_30653496delTGC	ENST00000274853.3	-	1	2176_2178	c.300_302delGCA	c.(298-303)caa>ca	p.QQ102del	PPP1R18_ENST00000399199.3_In_Frame_Del_p.QQ102del|PPP1R18_ENST00000488324.1_Intron	NM_133471.3	NP_597728.1	Q6NYC8	PHTNS_HUMAN	protein phosphatase 1, regulatory subunit 18	102	Poly-Gln.					cytoplasm|cytoskeleton	actin binding	p.Q100Q(1)									CCGTtgttgttgctgctgctgct	0.650													12	277	---	---	---	---					
C6orf165	154313	broad.mit.edu	37	6	88144700	88144700	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:88144700delA	ENST00000507897.1	+	11	1506	c.1423delA	c.(1423-1425)aafs	p.K476fs	C6ORF165_ENST00000369562.4_Frame_Shift_Del_p.K476fs			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	476										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGAAAAGGCCAAAAAAAATAC	0.269													9	524	---	---	---	---					
OLIG3	167826	broad.mit.edu	37	6	137815210	137815212	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:137815210_137815212delTGG	ENST00000367734.2	-	1	319_321	c.96_98delCCA	c.(94-99)cag>ca	p.HQ32del		NM_175747.2	NP_786923.1	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	32	Poly-His.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.Q33K(1)		endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	11	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		ACGGCTCTCCtggtggtggtggt	0.596													8	407	---	---	---	---					
SHPRH	257218	broad.mit.edu	37	6	146264834	146264836	+	In_Frame_Del	DEL	ATC	ATC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr6:146264834_146264836delATC	ENST00000367503.3	-	9	2079_2081	c.1681_1683delGAT	c.(1681-1683)del	p.D561del	SHPRH_ENST00000438092.2_In_Frame_Del_p.D561del|SHPRH_ENST00000367505.2_In_Frame_Del_p.D561del|SHPRH_ENST00000275233.7_In_Frame_Del_p.D561del	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	561					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		AATAGTAAGGATCATCATCATCA	0.360													9	430	---	---	---	---					
CARD11	84433	broad.mit.edu	37	7	2963941	2963943	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:2963941_2963943delGGA	ENST00000396946.4	-	15	2267_2269	c.1864_1866delTCC	c.(1864-1866)del	p.S622del		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	622					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CGGATTGGTGGGAGGAGGAGGAG	0.616			Mis		DLBCL								8	559	---	---	---	---					
OSBPL3	26031	broad.mit.edu	37	7	24904971	24904971	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:24904971delT	ENST00000313367.2	-	7	1114	c.663delA	c.(661-663)aafs	p.K221fs	OSBPL3_ENST00000396431.1_Frame_Shift_Del_p.K221fs|OSBPL3_ENST00000396429.1_Frame_Shift_Del_p.K221fs|OSBPL3_ENST00000409069.1_Frame_Shift_Del_p.K221fs|OSBPL3_ENST00000352860.1_Frame_Shift_Del_p.K221fs|OSBPL3_ENST00000353930.1_Frame_Shift_Del_p.K221fs|OSBPL3_ENST00000431825.2_Frame_Shift_Del_p.K221fs	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	221					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						CTTTGGAGCATTTTTCCATGT	0.393													9	2087	---	---	---	---					
TRGC2	0	broad.mit.edu	37	7	38284914	38284917	+	RNA	DEL	CTGA	CTGA	-	rs147429736	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:38284914_38284917delCTGA	ENST00000436911.2	-	0	330																											gtgtgtgtgtctgagtgtgtctgt	0.392													12	215	---	---	---	---					
CCT6P3	0	broad.mit.edu	37	7	64528813	64528814	+	RNA	INS	-	-	T			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:64528813_64528814insT	ENST00000426828.1	+	0	621					NR_033416.1																						CTTTCTGTAACTTTTTTTTTTT	0.317													14	104	---	---	---	---					
FOXP2	93986	broad.mit.edu	37	7	114270016	114270018	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:114270016_114270018delCAG	ENST00000393500.3	+	11	1148_1150	c.328_330delCAG	c.(328-330)del	p.Q116del	FOXP2_ENST00000378237.3_In_Frame_Del_p.Q191del|FOXP2_ENST00000360232.4_In_Frame_Del_p.Q191del|FOXP2_ENST00000408937.3_In_Frame_Del_p.Q216del|FOXP2_ENST00000390668.3_In_Frame_Del_p.Q215del|FOXP2_ENST00000393491.3_In_Frame_Del_p.Q99del|FOXP2_ENST00000403559.4_In_Frame_Del_p.Q208del|FOXP2_ENST00000350908.4_In_Frame_Del_p.Q191del|FOXP2_ENST00000393494.2_In_Frame_Del_p.Q191del|FOXP2_ENST00000393498.2_In_Frame_Del_p.Q171del|FOXP2_ENST00000393489.3_In_Frame_Del_p.Q99del			O15409	FOXP2_HUMAN	forkhead box P2	191	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q210Q(2)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						gcagcagcaacagcagcagcagc	0.507													8	296	---	---	---	---					
TRBV29-1	0	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													12	55	---	---	---	---					
RBM33	155435	broad.mit.edu	37	7	155531073	155531074	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr7:155531073_155531074delCA	ENST00000401878.3	+	11	1911_1912	c.1713_1714delCA	c.(1711-1716)cccafs	p.PT571fs		NM_053043.2	NP_444271.2	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	571	Pro-rich.						nucleotide binding|RNA binding			breast(3)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	27	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		CGTTTCTGCCCACACACACACA	0.530													7	459	---	---	---	---					
RGS22	26166	broad.mit.edu	37	8	100990177	100990178	+	Frame_Shift_Ins	INS	-	-	T	rs7841915	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:100990177_100990178insT	ENST00000360863.6	-	23	3680_3681	c.3486_3487insA	c.(3484-3489)aatggcfs	p.NG1162fs	RGS22_ENST00000523437.1_Frame_Shift_Ins_p.NG1150fs|RGS22_ENST00000523287.1_Frame_Shift_Ins_p.NG981fs	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	1162					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			AGGACTGCCAATTTTTTTTTCT	0.312													10	346	---	---	---	---					
MYC	4609	broad.mit.edu	37	8	128750605	128750607	+	In_Frame_Del	DEL	CAG	CAG	-	rs61752959	byFrequency	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr8:128750605_128750607delCAG	ENST00000377970.2	+	2	652_654	c.142_144delCAG	c.(142-144)del	p.Q52del	MYC_ENST00000524013.1_In_Frame_Del_p.Q51del|MYC_ENST00000259523.6_In_Frame_Del_p.Q37del	NM_002467.4	NP_002458.2	P01106	MYC_HUMAN	v-myc avian myelocytomatosis viral oncogene homolog	37					branching involved in ureteric bud morphogenesis|cell cycle arrest|cell proliferation|cellular iron ion homeostasis|positive regulation of metanephric cap mesenchymal cell proliferation|positive regulation of transcription, DNA-dependent|regulation of telomere maintenance|regulation of transcription from RNA polymerase II promoter|response to drug	nucleolus|nucleoplasm	E-box binding|protein binding|sequence-specific DNA binding transcription factor activity	p.Q33H(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	all_cancers(1;6.19e-134)|all_epithelial(1;1.75e-119)|all_lung(1;5.66e-51)|Breast(1;1.08e-22)|all_neural(1;4.45e-21)|Medulloblastoma(1;1.88e-20)|Colorectal(1;1.92e-09)|Lung SC(1;4.52e-07)|Ovarian(5;0.000122)|Esophageal squamous(12;0.000995)|Renal(1;0.0921)|Hepatocellular(40;0.108)|Myeloproliferative disorder(2;0.135)|Melanoma(291;0.185)	Myeloproliferative disorder(644;0.0255)|Ovarian(118;0.0654)|Breast(495;0.212)|Acute lymphoblastic leukemia(644;0.22)	Epithelial(1;1.63e-94)|all cancers(1;5.82e-87)|OV - Ovarian serous cystadenocarcinoma(1;2.12e-71)|BRCA - Breast invasive adenocarcinoma(1;4.3e-14)|Lung(2;0.000381)|Colorectal(2;0.0102)|LUAD - Lung adenocarcinoma(14;0.0172)|READ - Rectum adenocarcinoma(2;0.0723)|LUSC - Lung squamous cell carcinoma(258;0.151)	KIRC - Kidney renal clear cell carcinoma(542;0.248)		GAACTTCTACCAGCAGCAGCAGC	0.611		3	"""A, T"""	"""IGK@, BCL5, BCL7A , BTG1, TRA@, IGH@"""	"""Burkitt lymphoma,  amplified in other cancers, B-CLL"""						OREG0018982	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	373	---	---	---	---					
RUSC2	9853	broad.mit.edu	37	9	35560102	35560104	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:35560102_35560104delGCT	ENST00000455600.1	+	10	4034_4036	c.3465_3467delGCT	c.(3463-3468)gag>ga	p.EL1155del		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1155	RUN.					cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			TCTTTGAAGAGCTGCTGCTGCTG	0.616													8	788	---	---	---	---					
HRCT1	646962	broad.mit.edu	37	9	35906348	35906350	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:35906348_35906350delCTG	ENST00000354323.2	+	1	160_162	c.64_66delCTG	c.(64-66)del	p.L28del		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	28						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						TGTGGCGGTCctgctgctgctgc	0.670													7	87	---	---	---	---					
ROR2	4920	broad.mit.edu	37	9	94486026	94486028	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:94486026_94486028delTCC	ENST00000375708.3	-	9	2946_2948	c.2748_2750delGGA	c.(2746-2751)gaa>ga	p.EE916del	ROR2_ENST00000375715.1_Intron|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	916					negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GACAGAGCCTTCCTCCTCCTCCT	0.645													8	567	---	---	---	---					
ASTN2	23245	broad.mit.edu	37	9	119976989	119976991	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr9:119976989_119976991delCAG	ENST00000313400.4	-	3	761_763	c.661_663delCTG	c.(661-663)del	p.L221del	ASTN2_ENST00000361209.2_In_Frame_Del_p.L221del|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_In_Frame_Del_p.L221del			O75129	ASTN2_HUMAN	astrotactin 2	221						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CGGTGAACACCAGCAGCAGCAGC	0.601													7	262	---	---	---	---					
PHRF1	57661	broad.mit.edu	37	11	592586	592588	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:592586_592588delGAG	ENST00000264555.5	+	6	660_662	c.532_534delGAG	c.(532-534)del	p.E181del	PHRF1_ENST00000533464.1_In_Frame_Del_p.E177del|PHRF1_ENST00000413872.2_In_Frame_Del_p.E180del|PHRF1_ENST00000416188.2_In_Frame_Del_p.E181del	NM_020901.2	NP_065952.2	Q9P1Y6	PHRF1_HUMAN	PHD and ring finger domains 1	181	Poly-Glu.						RNA polymerase binding|zinc ion binding			breast(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|urinary_tract(2)	28						CAAAGCGAGCGAGGAGGAGGAGG	0.616													9	877	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14276276	14276277	+	RNA	DEL	GT	GT	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:14276276_14276277delGT	ENST00000310358.7	+	0	1627							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GACCTATGAGGTGTGTGTGTGT	0.594													23	638	---	---	---	---					
LRRC32	2615	broad.mit.edu	37	11	76372197	76372198	+	Frame_Shift_Ins	INS	-	-	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:76372197_76372198insC	ENST00000407242.2	-	3	681_682	c.439_440insG	c.(439-441)ggcfs	p.G147fs	AP001189.4_ENST00000447519.1_RNA|LRRC32_ENST00000260061.5_Frame_Shift_Ins_p.G147fs|LRRC32_ENST00000464145.1_Intron|LRRC32_ENST00000404995.1_Frame_Shift_Ins_p.G147fs	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	147						integral to plasma membrane				endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						GCTGGGTGCCTCCCCCAGCAGC	0.678													7	204	---	---	---	---					
FOLH1B	219595	broad.mit.edu	37	11	89405323	89405326	+	RNA	DEL	TTTA	TTTA	-	rs34562444		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:89405323_89405326delTTTA	ENST00000532352.1	+	0	1114							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						aattatattgtttatttatttttg	0.230													7	6	---	---	---	---					
MMP13	4322	broad.mit.edu	37	11	102818723	102818723	+	Frame_Shift_Del	DEL	T	T	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:102818723delT	ENST00000260302.3	-	8	1136	c.1108delA	c.(1108-1110)tafs	p.I370fs	MMP13_ENST00000340273.4_Frame_Shift_Del_p.I370fs	NM_002427.3	NP_002418.1	P45452	MMP13_HUMAN	matrix metallopeptidase 13 (collagenase 3)	370	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|skin(1)|stomach(1)	27		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		AGTTCAGATATTTTTTTGGGA	0.388													7	810	---	---	---	---					
DDX10	1662	broad.mit.edu	37	11	108788635	108788637	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:108788635_108788637delTGA	ENST00000526794.1	+	17	2372_2374	c.2340_2342delTGA	c.(2338-2343)agt>ag	p.SD780del	DDX10_ENST00000322536.3_In_Frame_Del_p.SD780del			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	780							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		TGGATTGGAGtgatgatgatgat	0.355			T	NUP98	AML*								10	295	---	---	---	---					
SIDT2	51092	broad.mit.edu	37	11	117064645	117064647	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:117064645_117064647delTCT	ENST00000324225.4	+	24	2819_2821	c.2288_2290delTCT	c.(2287-2292)ctc>c	p.LF763del	SIDT2_ENST00000431081.2_In_Frame_Del_p.LF760del|SIDT2_ENST00000532062.1_In_Frame_Del_p.LF55del	NM_001040455.1	NP_001035545.1	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2	763						integral to membrane|lysosomal membrane				NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	36	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		GGCTTCGCGCTCTTCTTCTTCTT	0.601													9	319	---	---	---	---					
DDX6	1656	broad.mit.edu	37	11	118629613	118629614	+	Splice_Site	INS	-	-	G			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr11:118629613_118629614insG	ENST00000264018.4	-	9	1170		c.e9-2		DDX6_ENST00000534980.1_Splice_Site|DDX6_ENST00000526070.2_Splice_Site	NM_004397.4	NP_004388.2	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 6						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	13	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		ATGGGAATTCTGGGGGGGGAGC	0.426			T	IGH@	B-NHL								14	756	---	---	---	---					
TAS2R50	259296	broad.mit.edu	37	12	11139432	11139432	+	Frame_Shift_Del	DEL	A	A	-	rs79147066		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:11139432delA	ENST00000506868.1	-	1	79	c.28delT	c.(28-30)cafs	p.S10fs	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176890.2	NP_795371.2	P59544	T2R50_HUMAN	taste receptor, type 2, member 50	10					sensory perception of taste	integral to membrane	G-protein coupled receptor activity	p.S10fs*3(2)|p.S10fs*25(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)	17						ATTAGAATTGAAAAAAAAATG	0.318													7	268	---	---	---	---					
C12orf40	283461	broad.mit.edu	37	12	40076540	40076540	+	Frame_Shift_Del	DEL	A	A	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:40076540delA	ENST00000324616.5	+	8	968	c.814delA	c.(814-816)aafs	p.K272fs	C12orf40_ENST00000405531.3_Frame_Shift_Del_p.K272fs|C12orf40_ENST00000398716.1_Frame_Shift_Del_p.K195fs	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	272										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						TATTTGGGGGAAAAATGGAAA	0.353													7	793	---	---	---	---					
OR10A7	121364	broad.mit.edu	37	12	55615114	55615116	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:55615114_55615116delCTT	ENST00000326258.1	+	1	306_308	c.306_308delCTT	c.(304-309)tac>ta	p.YF102del		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						CCCAGATGTACTTCTTCTTCTTC	0.414													7	798	---	---	---	---					
MLEC	9761	broad.mit.edu	37	12	121134166	121134168	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr12:121134166_121134168delGAA	ENST00000228506.3	+	5	1125_1127	c.697_699delGAA	c.(697-699)del	p.E238del	MLEC_ENST00000412616.2_In_Frame_Del_p.RK154del	NM_014730.2	NP_055545.1	Q14165	MLEC_HUMAN	malectin	238	Poly-Glu.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding	p.E233E(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	16						gaaagaagaggaagaagaagaag	0.458													11	688	---	---	---	---					
DDX24	57062	broad.mit.edu	37	14	94545821	94545823	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr14:94545821_94545823delCCT	ENST00000330836.5	-	2	397_399	c.266_268delAGG	c.(265-270)gga>g	p.EG89del	DDX24_ENST00000555054.1_In_Frame_Del_p.EG46del|DDX24_ENST00000544005.1_Intron	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	89	Poly-Glu.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		CTAGACTTTCCCTCCTCCTCCTC	0.443													8	692	---	---	---	---					
IGHV4OR15-8	0	broad.mit.edu	37	15	22473268	22473268	+	RNA	DEL	G	G	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:22473268delG	ENST00000557788.2	-	0	46																											ATCAGAGGCAGCCTCCCCTAT	0.582													15	353	---	---	---	---					
EMC7	56851	broad.mit.edu	37	15	34393991	34393993	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:34393991_34393993delAGC	ENST00000256545.4	-	1	156_158	c.48_50delGCT	c.(46-51)cta>ct	p.LL16del	EMC7_ENST00000532113.1_5'UTR	NM_020154.2	NP_064539.1			ER membrane protein complex subunit 7																		ATCCCCCGATAGCAGCAGCAGCA	0.665													9	620	---	---	---	---					
SLC24A1	9187	broad.mit.edu	37	15	65943128	65943130	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr15:65943128_65943130delGAG	ENST00000261892.6	+	7	2928_2930	c.2641_2643delGAG	c.(2641-2643)del	p.E890del	SLC24A1_ENST00000449142.2_3'UTR|SLC24A1_ENST00000537259.1_In_Frame_Del_p.E872del|SLC24A1_ENST00000546330.1_In_Frame_Del_p.E872del|SLC24A1_ENST00000399033.4_In_Frame_Del_p.E890del|SLC24A1_ENST00000339868.6_In_Frame_Del_p.E872del|SLC24A1_ENST00000544319.2_In_Frame_Del_p.E776del	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	890	Poly-Glu.				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						gcaggaggaagaggaggaggagg	0.562													9	160	---	---	---	---					
ZNF598	90850	broad.mit.edu	37	16	2049882	2049883	+	In_Frame_Ins	INS	-	-	TCC	rs61746014	by1000genomes	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr16:2049882_2049883insTCC	ENST00000563630.1	-	9	1744_1745	c.1502_1503insGGA	c.(1501-1503)ggg>gGGAgg	p.501_502insR	ZNF598_ENST00000562103.1_In_Frame_Ins_p.501_502insR|ZNF598_ENST00000431526.1_In_Frame_Ins_p.556_557insR			Q86UK7	ZN598_HUMAN	zinc finger protein 598	556						intracellular	zinc ion binding	p.E555_D556insE(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						CCGGGCCGCCGTCCTCCTCCTC	0.703													17	19	---	---	---	---					
EIF3C	8663	broad.mit.edu	37	16	28734579	28734581	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr16:28734579_28734581delGAG	ENST00000331666.6	+	9	1057_1059	c.871_873delGAG	c.(871-873)del	p.E294del	EIF3C_ENST00000395587.1_In_Frame_Del_p.E294del|EIF3C_ENST00000564243.1_In_Frame_Del_p.E284del|EIF3C_ENST00000566866.1_In_Frame_Del_p.E294del|EIF3C_ENST00000566501.1_In_Frame_Del_p.E294del			Q99613	EIF3C_HUMAN	eukaryotic translation initiation factor 3, subunit C	294	Poly-Glu.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(5)|skin(1)	6						GCGCCTGGATGAGGAGGAGGAGG	0.562													11	2761	---	---	---	---					
ITGAL	0	broad.mit.edu	37	16	30531249	30531251	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr16:30531249_30531251delGCT	ENST00000356798.6	+	30	3480_3482	c.3300_3302delGCT	c.(3298-3303)ggg>gg	p.GL1100del	ITGAL_ENST00000358164.5_In_Frame_Del_p.GL1016del|ITGAL_ENST00000433423.2_In_Frame_Del_p.GL334del	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	1100					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GCATCGGGGGGCTGCTGCTGCTG	0.601													9	782	---	---	---	---					
IRX6	79190	broad.mit.edu	37	16	55362674	55362676	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr16:55362674_55362676delGAG	ENST00000290552.7	+	5	2116_2118	c.784_786delGAG	c.(784-786)del	p.E268del	RP11-26L20.3_ENST00000558730.2_RNA	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	268						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						CCTggaggaagaggaggaggagg	0.626													7	253	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72821594	72821596	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr16:72821594_72821596delGCC	ENST00000268489.5	-	10	11251_11253	c.10579_10581delGGC	c.(10579-10581)del	p.G3527del	ZFHX3_ENST00000397992.5_In_Frame_Del_p.G2613del|AC004943.1_ENST00000584072.1_RNA	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3527	Poly-Gly.		G -> GGG.		muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				AGTGGTACGAgccgccgccgccg	0.690													14	358	---	---	---	---					
RP11-150D5.2	0	broad.mit.edu	37	16	76268905	76268905	+	RNA	DEL	T	T	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr16:76268905delT	ENST00000568714.1	-	0	135																											ttttcttttctttttttttGC	0.418													8	185	---	---	---	---					
GSE1	23199	broad.mit.edu	37	16	85682290	85682290	+	Frame_Shift_Del	DEL	C	C	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr16:85682290delC	ENST00000253458.7	+	3	535	c.359delC	c.(358-360)acfs	p.T120fs	GSE1_ENST00000405402.2_Frame_Shift_Del_p.T16fs|GSE1_ENST00000393243.1_Frame_Shift_Del_p.T47fs	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein									p.V123fs*2(1)									GTGCCCAGCACCCCCCCCGTG	0.687													7	409	---	---	---	---					
C17orf85	55421	broad.mit.edu	37	17	3721809	3721811	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:3721809_3721811delTCC	ENST00000158149.3	-	11	1111_1113	c.216_218delGGA	c.(214-219)gaa>ga	p.EE78del	C17orf85_ENST00000389005.4_In_Frame_Del_p.EE358del			Q53F19	CQ085_HUMAN	chromosome 17 open reading frame 85	358							nucleotide binding			endometrium(2)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		ctcttcctcttcctcctcctcct	0.507													13	659	---	---	---	---					
KDM6B	23135	broad.mit.edu	37	17	7751859	7751861	+	In_Frame_Del	DEL	CAC	CAC	-	rs59627144		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:7751859_7751861delCAC	ENST00000254846.5	+	11	2642_2644	c.2253_2255delCAC	c.(2251-2256)gtc>gt	p.VT751del	KDM6B_ENST00000448097.2_In_Frame_Del_p.VT751del	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	751	Pro-rich.|Thr-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						CTGTCGCCGTcaccaccaccacc	0.650													7	147	---	---	---	---					
SLC26A11	284129	broad.mit.edu	37	17	78201649	78201651	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr17:78201649_78201651delTGC	ENST00000361193.3	+	7	906_908	c.626_628delTGC	c.(625-630)atg>a	p.ML209del	SLC26A11_ENST00000546047.2_In_Frame_Del_p.ML209del|SLC26A11_ENST00000572725.1_In_Frame_Del_p.ML209del|SLC26A11_ENST00000411502.3_In_Frame_Del_p.ML209del	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	209						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CTGGTCTGCATGCTGCTGCTGCT	0.675													7	496	---	---	---	---					
YIPF2	78992	broad.mit.edu	37	19	11038362	11038364	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:11038362_11038364delGCT	ENST00000586748.1	-	4	393_395	c.221_223delAGC	c.(220-225)ccg>c	p.QP74del	YIPF2_ENST00000590329.1_In_Frame_Del_p.QP74del|YIPF2_ENST00000253031.2_In_Frame_Del_p.QP74del			Q9BWQ6	YIPF2_HUMAN	Yip1 domain family, member 2	74						integral to membrane|transport vesicle				cervix(1)|endometrium(1)|lung(3)|ovary(2)	7						CAGAATCCCGgctgctgctgctg	0.621													7	253	---	---	---	---					
HAMP	57817	broad.mit.edu	37	19	35773520	35773522	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:35773520_35773522delCTC	ENST00000598398.1	+	2	336_338	c.40_42delCTC	c.(40-42)del	p.L18del	HAMP_ENST00000222304.3_In_Frame_Del_p.L18del	NM_021175.2	NP_066998.1	P81172	HEPC_HUMAN	hepcidin antimicrobial peptide	18					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)	4	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TTGCCTCCTGCTCCTCCTCCTCC	0.640													12	976	---	---	---	---					
HNRNPL	3191	broad.mit.edu	37	19	39340485	39340497	+	Frame_Shift_Del	DEL	CCGCCGCCCGCCG	CCGCCGCCCGCCG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:39340485_39340497delCCGCCGCCCGCCG	ENST00000221419.5	-	1	476_488	c.110_122delCGGCGGGCGGCGG	c.(109-123)gafs	p.AAGGG37fs	HNRNPL_ENST00000600873.1_Intron	NM_001533.2	NP_001524.2	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	37					nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			accgccgcctccgccgcccgccgccgccATCTT	0.765													7	36	---	---	---	---					
PRX	57716	broad.mit.edu	37	19	40900180	40900182	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:40900180_40900182delTCC	ENST00000324001.7	-	7	4347_4349	c.4077_4079delGGA	c.(4075-4080)gaa>ga	p.EE1359del	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	1359	Poly-Glu.		Missing.		axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACTGCcctcttcctcctcctcct	0.695													9	121	---	---	---	---					
ERF	2077	broad.mit.edu	37	19	42753026	42753027	+	Frame_Shift_Ins	INS	-	-	C			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:42753026_42753027insC	ENST00000222329.4	-	4	1394_1395	c.1237_1238insG	c.(1237-1239)aggfs	p.R413fs	ERF_ENST00000440177.2_Frame_Shift_Ins_p.R338fs|AC006486.9_ENST00000594664.1_Intron	NM_006494.2	NP_006485.2	P50548	ERF_HUMAN	Ets2 repressor factor	413					cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	17		Prostate(69;0.00682)				TAGCGCCCCTGCCCCCTCAGCC	0.698													13	527	---	---	---	---					
TMC4	147798	broad.mit.edu	37	19	54675747	54675749	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr19:54675747_54675749delTCC	ENST00000376591.4	-	2	332_334	c.201_203delGGA	c.(199-204)gat>ga	p.ED67del	TMC4_ENST00000301187.4_In_Frame_Del_p.ED61del	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	67	Poly-Glu.					integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCTTCCTCCATCCTCCTCCTCCT	0.645													11	488	---	---	---	---					
C20orf26	26074	broad.mit.edu	37	20	20243740	20243746	+	Frame_Shift_Del	DEL	GATTTGG	GATTTGG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:20243740_20243746delGATTTGG	ENST00000245957.5	+	21	2545_2551	c.2469_2475delGATTTGG	c.(2467-2475)ctfs	p.LIW823fs	C20orf26_ENST00000389656.3_Frame_Shift_Del_p.LIW179fs|C20orf26_ENST00000377293.1_Frame_Shift_Del_p.LIW179fs|C20orf26_ENST00000377309.2_Frame_Shift_Del_p.LIW179fs|RP5-1096J16.1_ENST00000460400.1_RNA	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	823										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		TTAAGGCACTGATTTGGATAAGGAATA	0.440													13	819	---	---	---	---					
NCOA3	8202	broad.mit.edu	37	20	46279864	46279866	+	In_Frame_Del	DEL	CAA	CAA	-	rs112129664	byFrequency	TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:46279864_46279866delCAA	ENST00000372004.3	+	20	3994_3996	c.3778_3780delCAA	c.(3778-3780)del	p.Q1272del	NCOA3_ENST00000371997.3_In_Frame_Del_p.Q1267del|NCOA3_ENST00000371998.3_In_Frame_Del_p.Q1276del|NCOA3_ENST00000341724.6_In_Frame_Del_p.Q1202del	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1276	Acetyltransferase.|Poly-Gln.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						gcagcagcagcaacagcaacagc	0.567													8	283	---	---	---	---					
YTHDF1	54915	broad.mit.edu	37	20	61833650	61833652	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr20:61833650_61833652delCCT	ENST00000370339.3	-	4	1981_1983	c.1640_1642delAGG	c.(1639-1644)gtg>g	p.EV547del	YTHDF1_ENST00000370334.4_Intron|YTHDF1_ENST00000370333.4_In_Frame_Del_p.EV497del	NM_017798.3	NP_060268.2	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	547										NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)	24						TTGCGCACCACCTCCTCCTCCTC	0.557													8	812	---	---	---	---					
TPTEP1	0	broad.mit.edu	37	22	17131430	17131432	+	RNA	DEL	CAC	CAC	-	rs142037179		TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:17131430_17131432delCAC	ENST00000426585.1	+	0	2456_2458																											caccatccatcaccaacagaaac	0.443													9	3	---	---	---	---					
MED15	51586	broad.mit.edu	37	22	20918916	20918918	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:20918916_20918918delCAG	ENST00000263205.7	+	6	700_702	c.631_633delCAG	c.(631-633)del	p.Q218del	MED15_ENST00000406969.1_In_Frame_Del_p.Q192del|MED15_ENST00000542773.1_In_Frame_Del_p.Q23del|MED15_ENST00000541476.1_In_Frame_Del_p.Q192del|MED15_ENST00000425759.2_In_Frame_Del_p.Q107del|MED15_ENST00000382974.2_In_Frame_Del_p.Q147del|MED15_ENST00000292733.7_In_Frame_Del_p.Q218del	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	218	Poly-Gln.			Missing (in Ref. 4; CAG30423).	regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			gcagcagctccagcagcagcagc	0.567											OREG0026319	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	153	---	---	---	---					
PICK1	9463	broad.mit.edu	37	22	38471034	38471036	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:38471034_38471036delGGA	ENST00000404072.3	+	13	1490_1492	c.1143_1145delGGA	c.(1141-1146)ggg>gg	p.GE381del	PICK1_ENST00000356976.3_In_Frame_Del_p.GE381del	NM_001039583.1|NM_001039584.1	NP_001034672.1|NP_001034673.1	Q9NRD5	PICK1_HUMAN	protein interacting with PRKCA 1	381					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	Melanoma(58;0.045)					TCACAGATGGggaggaggaggag	0.635													9	204	---	---	---	---					
SREBF2	6721	broad.mit.edu	37	22	42262949	42262951	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chr22:42262949_42262951delGCA	ENST00000361204.4	+	2	369_371	c.203_205delGCA	c.(202-207)ggc>g	p.GS68del		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	68	Gly/Pro/Ser-rich.				cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						ggcagcagtggcagcagcagcag	0.567													11	533	---	---	---	---					
PHF8	23133	broad.mit.edu	37	X	54011405	54011407	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chrX:54011405_54011407delCTC	ENST00000338154.6	-	18	2887_2889	c.2383_2385delGAG	c.(2383-2385)del	p.E795del	PHF8_ENST00000357988.5_In_Frame_Del_p.E831del|PHF8_ENST00000322659.8_In_Frame_Del_p.E778del|PHF8_ENST00000338946.6_In_Frame_Del_p.E694del	NM_015107.2	NP_055922.1	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	831	Ser-rich.				brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	40						GACTGGCGTTCTCCTCCTCCTCC	0.591													12	749	---	---	---	---					
BHLHB9	80823	broad.mit.edu	37	X	102004419	102004421	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chrX:102004419_102004421delGAG	ENST00000372735.1	+	4	1081_1083	c.496_498delGAG	c.(496-498)del	p.E171del	BHLHB9_ENST00000448867.1_In_Frame_Del_p.E171del|BHLHB9_ENST00000447531.1_In_Frame_Del_p.E171del|BHLHB9_ENST00000361229.4_In_Frame_Del_p.E171del|BHLHB9_ENST00000457056.1_In_Frame_Del_p.E171del			Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class B, 9	171	Poly-Glu.					cytoplasm|nucleus	binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GTCAGGGGCTGAGGAGGAGGAGG	0.488													14	698	---	---	---	---					
ZBTB33	10009	broad.mit.edu	37	X	119388276	119388278	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-2J-AABP-01A-11D-A40W-08	TCGA-2J-AABP-10A-01D-A40W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	662cdf99-f06e-4888-a37b-0ac40290812e	9004caef-8e7c-48c3-935f-b42764af6613	g.chrX:119388276_119388278delGAT	ENST00000326624.2	+	2	1234_1236	c.1006_1008delGAT	c.(1006-1008)del	p.D340del	ZBTB33_ENST00000557385.1_In_Frame_Del_p.D340del	NM_006777.3	NP_006768.1	Q86T24	KAISO_HUMAN	zinc finger and BTB domain containing 33	340					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	26						GGAAATAATAGATGATGATGATG	0.433													9	468	---	---	---	---