Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NUP205	23165	broad.mit.edu	37	7	135289192	135289192	+	Missense_Mutation	SNP	A	A	T			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr7:135289192A>T	ENST00000285968.6	+	19	2833	c.2807A>T	c.(2806-2808)gAt>gTt	p.D936V		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	936					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						TTGGTTGGAGATTTCACACAT	0.353000													4	67					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179454380	179454380	+	Missense_Mutation	SNP	C	C	T			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr2:179454380C>T	ENST00000589042.1	-	304	62296	c.62072G>A	c.(62071-62073)aGg>aAg	p.R20691K	TTN_ENST00000342992.6_Missense_Mutation_p.R18123K|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R11626K|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R11751K|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R19050K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R11818K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19050							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAGTCAGGCCTCCGCCACTT	0.443000													5	188					0	0	1	0	0
UGT2B17	7367	broad.mit.edu	37	4	69416530	69416530	+	Missense_Mutation	SNP	C	C	T			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr4:69416530C>T	ENST00000317746.2	-	5	1220	c.1178G>A	c.(1177-1179)gGc>gAc	p.G393D		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	393					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.G393D(1)		central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						CAAGGGAATGCCCACCATAGG	0.458000													4	252					0	0	1	0	0
GATAD1	57798	broad.mit.edu	37	7	92083921	92083921	+	Missense_Mutation	SNP	A	A	G			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr7:92083921A>G	ENST00000287957.3	+	4	818	c.541A>G	c.(541-543)Aag>Gag	p.K181E		NM_021167.4	NP_066990.3	Q8WUU5	GATD1_HUMAN	GATA zinc finger domain containing 1	181							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|lung(3)	6	all_cancers(62;1.63e-10)|all_epithelial(64;8.33e-10)|Breast(17;0.00311)|all_lung(186;0.0498)|Lung NSC(181;0.0676)		STAD - Stomach adenocarcinoma(171;4.51e-05)|GBM - Glioblastoma multiforme(5;8.83e-05)|all cancers(6;0.000136)|Lung(22;0.123)|Epithelial(20;0.179)|LUSC - Lung squamous cell carcinoma(200;0.225)			GTATTGCGAGAAGAGTGCAGC	0.443000													28	55					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846144	43846144	+	Missense_Mutation	SNP	T	T	A			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr12:43846144T>A	ENST00000389420.3	-	14	2011	c.2012A>T	c.(2011-2013)gAt>gTt	p.D671V	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.D671V	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	671	Cys-rich.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		TTCAACCATATCCTTCAATAG	0.338000													21	29					0	0	1	0	0
PER1	5187	broad.mit.edu	37	17	8045151	8045151	+	Missense_Mutation	SNP	C	C	G			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr17:8045151C>G	ENST00000317276.4	-	22	3809	c.3572G>C	c.(3571-3573)gGc>gCc	p.G1191A	PER1_ENST00000581082.1_Missense_Mutation_p.G1168A	NM_002616.2	NP_002607.2	O15534	PER1_HUMAN	period circadian clock 1	1191	CRY binding domain (By similarity).				circadian rhythm|entrainment of circadian clock|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(15)|ovary(4)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						AGGCAGTTGGCCCTTCCGGAC	0.577000			T	ETV6	"""AML, CMML"""			Other conserved DNA damage response genes					5	111					0	0	1	0	0
MED26	9441	broad.mit.edu	37	19	16687787	16687787	+	Missense_Mutation	SNP	G	G	A			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr19:16687787G>A	ENST00000263390.3	-	3	1116	c.854C>T	c.(853-855)gCc>gTc	p.A285V	CTD-3222D19.2_ENST00000409035.1_Missense_Mutation_p.A293V	NM_004831.3	NP_004822.2	O95402	MED26_HUMAN	mediator complex subunit 26	285	Pro-rich.				regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|RNA polymerase II transcription cofactor activity|transcription coactivator activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|skin(1)	8						CTGCTGCCGGGCAAAGGAGCC	0.672000													3	35					0	0	1	0	0
ZNF496	84838	broad.mit.edu	37	1	247492595	247492595	+	Silent	SNP	G	G	T			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr1:247492595G>T	ENST00000294753.4	-	3	750	c.286C>A	c.(286-288)Cgg>Agg	p.R96R	ZNF496_ENST00000366498.2_Silent_p.R96R	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	96	SCAN box.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			TGGATCTCCCGGGGCAGGATG	0.697000													5	44					0.00116845	0.00123336	1	1	0
MYO5B	4645	broad.mit.edu	37	18	47488727	47488727	+	Missense_Mutation	SNP	C	C	G			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr18:47488727C>G	ENST00000285039.7	-	12	1753	c.1454G>C	c.(1453-1455)tGg>tCg	p.W485S		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	485	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		AATCAGGGTCCAAGGGATCTG	0.423000													10	50					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109371681	109371681	+	Missense_Mutation	SNP	T	T	G			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr2:109371681T>G	ENST00000283195.6	+	17	2558	c.2432T>G	c.(2431-2433)cTg>cGg	p.L811R		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	811					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding	p.L811R(2)	RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						AATTCTTTACTGAAAATGATT	0.353000													7	250					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233363071	233363071	+	Missense_Mutation	SNP	C	C	T			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr1:233363071C>T	ENST00000258229.8	-	10	2639	c.2405G>A	c.(2404-2406)gGa>gAa	p.G802E	PCNXL2_ENST00000430153.1_Missense_Mutation_p.G101E	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	802						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GTTAAATTTTCCTTGTGTTGA	0.398000													3	47					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149510857	149510857	+	RNA	SNP	G	G	A			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr7:149510857G>A	ENST00000378016.2	+	0	10142							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCGGGTGCTCGGCTGGCAAGG	0.672000													4	40					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50696701	50696701	+	Missense_Mutation	SNP	T	T	G			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr6:50696701T>G	ENST00000008391.3	+	4	959	c.731T>G	c.(730-732)cTc>cGc	p.L244R	TFAP2D_ENST00000492804.1_3'UTR	NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	244							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					CCTGAGTGCCTCAATGCTTCA	0.468000													20	61					0	0	1	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34826576	34826576	+	Missense_Mutation	SNP	G	G	C			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr6:34826576G>C	ENST00000192788.5	+	14	2614	c.2443G>C	c.(2443-2445)Gat>Cat	p.D815H	UHRF1BP1_ENST00000452449.2_Missense_Mutation_p.D815H	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	815										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						GGATGTAGCAGATGTTCATAT	0.507000													7	161					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183245322	183245322	+	Missense_Mutation	SNP	T	T	A			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr4:183245322T>A	ENST00000511685.1	+	2	272	c.149T>A	c.(148-150)tTt>tAt	p.F50Y	TENM3_ENST00000406950.2_Missense_Mutation_p.F50Y					teneurin transmembrane protein 3																		TTGAAAGCTTTTGATCATGAT	0.507000													5	52					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189063419	189063419	+	Missense_Mutation	SNP	C	C	A			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr4:189063419C>A	ENST00000332517.3	+	3	658	c.518C>A	c.(517-519)aCt>aAt	p.T173N	RP11-366H4.3_ENST00000501322.2_RNA	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	173					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GAAACAAAGACTTGTAAACAG	0.423000													8	12					1.12685e-05	1.22344e-05	1	1	0
OFCC1	266553	broad.mit.edu	37	6	9933066	9933066	+	Missense_Mutation	SNP	G	G	A			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr6:9933066G>A	ENST00000316020.6	-	4	396	c.397C>T	c.(397-399)Ccg>Tcg	p.P133S	OFCC1_ENST00000472329.1_5'UTR					orofacial cleft 1 candidate 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|stomach(1)	11	Ovarian(93;0.0473)|Breast(50;0.201)	all_hematologic(90;0.124)				GTGCGATCCGGCATGTCGTGT	0.468000													4	154					0	0	1	0	0
IPO5	3843	broad.mit.edu	37	13	98658492	98658492	+	Missense_Mutation	SNP	C	C	T			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr13:98658492C>T	ENST00000261574.5	+	17	1840	c.1660C>T	c.(1660-1662)Cca>Tca	p.P554S	IPO5_ENST00000493492.2_3'UTR|IPO5_ENST00000490680.1_Missense_Mutation_p.P536S|IPO5_ENST00000539640.1_Missense_Mutation_p.P411S	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	536					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						TTTATTTATGCCATCACTGAA	0.408000													4	117					0	0	1	0	0
ANAPC7	51434	broad.mit.edu	37	12	110834213	110834213	+	Missense_Mutation	SNP	T	T	G			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr12:110834213T>G	ENST00000455511.3	-	2	248	c.248A>C	c.(247-249)cAt>cCt	p.H83P	ANAPC7_ENST00000450008.2_Missense_Mutation_p.H83P|RP11-478C19.2_ENST00000550231.1_RNA	NM_016238.2	NP_057322.2	Q9UJX3	APC7_HUMAN	anaphase promoting complex subunit 7	83					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)	19						AGAATCTGCATGATACACCAA	0.393000													10	39					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240370244	240370244	+	Missense_Mutation	SNP	T	T	A			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr1:240370244T>A	ENST00000319653.9	+	5	2362	c.2132T>A	c.(2131-2133)cTt>cAt	p.L711H		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	711					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CATCAAGGGCTTGAGAATGGA	0.488000													7	44					0	0	1	0	0
PHF6	84295	broad.mit.edu	37	X	133549219	133549219	+	Silent	SNP	C	C	G			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chrX:133549219C>G	ENST00000370800.4	+	8	1047	c.906C>G	c.(904-906)ccC>ccG	p.P302P	PHF6_ENST00000416404.2_Intron|PHF6_ENST00000370799.1_Intron|PHF6_ENST00000370803.3_Intron|PHF6_ENST00000332070.3_Intron|PHF6_ENST00000394292.1_Intron	NM_032335.3	NP_115711.2	Q8IWS0	PHF6_HUMAN	PHD finger protein 6	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(88)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(1)|skin(1)|urinary_tract(1)	103	Acute lymphoblastic leukemia(192;0.000127)					GAGTACATCCCAAATTTATCC	0.284000			"""F, N, Splice, Mis"""		ETP ALL								6	157					0	0	1	0	0
SDF2	6388	broad.mit.edu	37	17	26976014	26976014	+	Missense_Mutation	SNP	T	T	G			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr17:26976014T>G	ENST00000247020.4	-	3	927	c.629A>C	c.(628-630)gAg>gCg	p.E210A	SDF2_ENST00000592250.1_5'UTR	NM_006923.3	NP_008854.2	Q99470	SDF2_HUMAN	stromal cell-derived factor 2	210					protein glycosylation	extracellular space|membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7	Lung NSC(42;0.00431)					GATTCACAGCTCTGCATGGTG	0.527000													6	76					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51393611	51393611	+	Silent	SNP	C	C	T			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr3:51393611C>T	ENST00000266037.9	+	42	4364	c.4341C>T	c.(4339-4341)cgC>cgT	p.R1447R		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1447	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GCTTCTATCGCGTCAACAATG	0.483000													4	50					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	48					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49656694	49656694	+	Missense_Mutation	SNP	A	A	G			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr19:49656694A>G	ENST00000252825.4	-	1	1987	c.1801T>C	c.(1801-1803)Tcc>Ccc	p.S601P	HRC_ENST00000595625.1_Missense_Mutation_p.S601P	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	601					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		TCCTCGCTGGAGGCACCTCCA	0.642000													9	18					0	0	1	0	0
AGTPBP1	23287	broad.mit.edu	37	9	88248216	88248216	+	Missense_Mutation	SNP	G	G	A			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr9:88248216G>A	ENST00000357081.3	-	14	1520	c.1376C>T	c.(1375-1377)cCt>cTt	p.P459L	AGTPBP1_ENST00000376083.3_Missense_Mutation_p.P419L|AGTPBP1_ENST00000432218.1_Missense_Mutation_p.P297L|AGTPBP1_ENST00000337006.4_3'UTR|AGTPBP1_ENST00000376109.3_Missense_Mutation_p.P471L			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	459					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						GCCTGCCGTAGGAACAACAAT	0.358000													8	93					0	0	1	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162326	33162326	+	RNA	SNP	C	C	T			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr5:33162326C>T	ENST00000510327.1	-	0	346																											GCCGCAAAACCGGGGGCAAGA	0.567000													4	32					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75651040	75651040	+	Missense_Mutation	SNP	G	G	A			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chrX:75651040G>A	ENST00000361470.2	+	1	2995	c.2717G>A	c.(2716-2718)cGt>cAt	p.R906H		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	906	Interaction with DTNA (By similarity).|MAGE 2.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						CCTAGAGCCCGTTTGGAAACC	0.483000													4	81					0	0	1	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168912	142168912	+	RNA	SNP	A	A	G			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr7:142168912A>G	ENST00000454561.2	-	0	133																											AGCCGAGTGAATTCTGGGCCT	0.582000													3	8					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													3	25					0	0	1	0	0
KRTAP1-1	81851	broad.mit.edu	37	17	39197549	39197549	+	Missense_Mutation	SNP	G	G	C			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr17:39197549G>C	ENST00000306271.4	-	1	164	c.101C>G	c.(100-102)tCc>tGc	p.S34C		NM_030967.2	NP_112229.1	Q07627	KRA11_HUMAN	keratin associated protein 1-1	34			Missing (in allele KAP1.7).|PSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQT SFCGFP -> R (in allele KAP1.6).			extracellular region|keratin filament		p.S34C(6)		NS(2)|endometrium(2)|kidney(5)|lung(4)|prostate(1)	14		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCTGGCAGGAGCTGGTCTC	0.612000													4	58					0	0	1	0	0
RP5-884C9.2	0	broad.mit.edu	37	1	38562824	38562825	+	RNA	DEL	AG	AG	-			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr1:38562824_38562825delAG	ENST00000432922.1	+	0	301																											ccacagaaacagagagagagag	0.500													4	3	---	---	---	---					
AC027612.3	0	broad.mit.edu	37	2	91899626	91899626	+	RNA	DEL	A	A	-			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr2:91899626delA	ENST00000436174.1	-	0	168																											CCAGAGGCTCAAAAAAAAAAA	0.289													3	6	---	---	---	---					
RGPD8	727851	broad.mit.edu	37	2	113146539	113146541	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr2:113146539_113146541delTCT	ENST00000302558.3	-	20	4172_4174	c.3981_3983delAGA	c.(3979-3984)gag>ga	p.EE1327del	RGPD8_ENST00000409750.1_In_Frame_Del_p.EE1187del	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8											endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						TCCATCTCTCTCTTCTTCTTGAG	0.404													2	4	---	---	---	---					
VPS13B	157680	broad.mit.edu	37	8	100874100	100874100	+	Frame_Shift_Del	DEL	G	G	-			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr8:100874100delG	ENST00000358544.2	+	58	11327	c.11216delG	c.(11215-11217)tgfs	p.W3739fs	VPS13B_ENST00000357162.2_Frame_Shift_Del_p.W3714fs|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3739					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CAGGAGGAGTGGCGGCGGCAG	0.672													2	4	---	---	---	---					
LINC01500	102723742	broad.mit.edu	37	14	59295080	59295080	+	RNA	DEL	G	G	-			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr14:59295080delG	ENST00000553762.1	+	0	129																											CCATGCTTCCGGGGAGCTCCT	0.577													2	4	---	---	---	---					
IRF2BPL	64207	broad.mit.edu	37	14	77493647	77493648	+	In_Frame_Ins	INS	-	-	GCGGCG	rs61991619		TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chr14:77493647_77493648insGCGGCG	ENST00000238647.3	-	1	1386_1387	c.488_489insCGCCGC	c.(487-489)ggc>gCGCCGCgc	p.163_163G>APR		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	163	Poly-Ala.					nucleus		p.A164delA(1)		endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						GTTCCACCgcagcggcggcggc	0.748													4	3	---	---	---	---					
STAG2	10735	broad.mit.edu	37	X	123215265	123215265	+	Frame_Shift_Del	DEL	T	T	-			TCGA-P7-A5NX-01A-11D-A35D-08	TCGA-P7-A5NX-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	10a03f37-2061-4bdd-9482-386663368479	bde6ff6a-cdff-4b0e-8e92-c87aa8962ed6	g.chrX:123215265delT	ENST00000371160.1	+	28	3101	c.2811delT	c.(2809-2811)aafs	p.N937fs	STAG2_ENST00000371145.3_Frame_Shift_Del_p.N937fs|STAG2_ENST00000371157.3_Frame_Shift_Del_p.N937fs|STAG2_ENST00000354548.5_Frame_Shift_Del_p.N868fs|STAG2_ENST00000218089.9_Frame_Shift_Del_p.N937fs|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000371144.3_Frame_Shift_Del_p.N937fs			Q8N3U4	STAG2_HUMAN	stromal antigen 2	937					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						ATGGCTATAATTTTGATAGAT	0.308													31	62	---	---	---	---