Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP1	6101	broad.mit.edu	37	8	55541350	55541350	+	Silent	SNP	C	C	T			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr8:55541350C>T	ENST00000220676.1	+	4	5056	c.4908C>T	c.(4906-4908)taC>taT	p.Y1636Y		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1636					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAAAACTGTACGGTAAAGCAG	0.373000													5	96					0	0	1	0	0
ELF3	1999	broad.mit.edu	37	1	201982405	201982405	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr1:201982405G>A	ENST00000359651.3	+	6	3976	c.784G>A	c.(784-786)Gag>Aag	p.E262K	ELF3_ENST00000367284.5_Missense_Mutation_p.E262K|RP11-510N19.5_ENST00000504773.1_RNA|ELF3_ENST00000367283.3_Missense_Mutation_p.E262K			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	262					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.E262*(1)		breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						GGACTGTCTCGAGGGCAAGAA	0.632000													10	30					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65916168	65916168	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr17:65916168T>G	ENST00000321892.4	+	15	5905	c.5844T>G	c.(5842-5844)atT>atG	p.I1948M	BPTF_ENST00000306378.6_Missense_Mutation_p.I1822M|BPTF_ENST00000424123.3_Missense_Mutation_p.I1809M|BPTF_ENST00000335221.5_Missense_Mutation_p.I1948M			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1948					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CAGAAATAATTAAGAGGAGAG	0.333000													4	101					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													3	45					0	0	1	0	0
C8orf33	65265	broad.mit.edu	37	8	146278159	146278159	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr8:146278159G>A	ENST00000331434.6	+	2	308	c.194G>A	c.(193-195)gGc>gAc	p.G65D		NM_023080.2	NP_075568.1	Q9H7E9	CH033_HUMAN	chromosome 8 open reading frame 33	65										endometrium(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;9.1e-38)|all cancers(56;7.37e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.243)		GATGAAGGCGGCACAGCGTCG	0.557000													3	55					0	0	1	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6085711	6085711	+	Silent	SNP	A	A	C			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr7:6085711A>C	ENST00000199389.6	-	6	767	c.621T>G	c.(619-621)gtT>gtG	p.V207V	EIF2AK1_ENST00000536084.1_Silent_p.V83V|EIF2AK1_ENST00000495565.1_5'UTR	NM_001134335.1|NM_014413.3	NP_001127807.1|NP_055228.2	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 1	207	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		CCTTCATGCAAACTGTTTTAG	0.254000													6	18					0	0	1	0	0
STXBP1	6812	broad.mit.edu	37	9	130434339	130434339	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr9:130434339C>T	ENST00000373302.3	+	12	1112	c.973C>T	c.(973-975)Cgg>Tgg	p.R325W	STXBP1_ENST00000481942.1_3'UTR|STXBP1_ENST00000373299.1_Missense_Mutation_p.R325W	NM_003165.3	NP_003156.1	P61764	STXB1_HUMAN	syntaxin binding protein 1	325					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|skin(2)	23						GACCACCATGCGGGACCTGTC	0.502000													3	52					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105409427	105409427	+	Silent	SNP	G	G	A			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr14:105409427G>A	ENST00000333244.5	-	7	12480	c.12361C>T	c.(12361-12363)Ctg>Ttg	p.L4121L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4121						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTGTCGGCCAGGGACAGGTCC	0.587000													8	409					0	0	1	0	0
RPF2	84154	broad.mit.edu	37	6	111346773	111346773	+	Silent	SNP	T	T	A			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr6:111346773T>A	ENST00000441448.2	+	10	1001	c.909T>A	c.(907-909)atT>atA	p.I303I		NM_032194.1	NP_115570.1	Q9H7B2	RPF2_HUMAN	ribosome production factor 2 homolog (S. cerevisiae)	303						nucleolus	protein binding	p.I303I(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|ovary(2)	7						CAAAAAGAATTAAAAAAAATT	0.368000													5	24					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54760448	54760448	+	Missense_Mutation	SNP	A	A	T			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr19:54760448A>T	ENST00000450632.1	-	3	336	c.259T>A	c.(259-261)Tcc>Acc	p.S87T	LILRB5_ENST00000345866.6_Missense_Mutation_p.S87T|LILRB5_ENST00000316219.5_Missense_Mutation_p.S87T|LILRB5_ENST00000449561.2_Missense_Mutation_p.S87T			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	87	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TACACCGTGGATGGAATGTGG	0.607000													53	208					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79580907	79580907	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr10:79580907C>A	ENST00000372391.2	-	15	3340	c.3335G>T	c.(3334-3336)cGg>cTg	p.R1112L	DLG5_ENST00000459739.1_5'UTR|DLG5_ENST00000372388.2_Intron	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	1112					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			AGATTTTGGCCGGCGACGCTT	0.602000													7	36					1.12685e-05	1.19728e-05	1	1	0
KRTAP1-1	81851	broad.mit.edu	37	17	39197281	39197281	+	Silent	SNP	G	G	A			TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr17:39197281G>A	ENST00000306271.4	-	1	432	c.369C>T	c.(367-369)tgC>tgT	p.C123C		NM_030967.2	NP_112229.1	Q07627	KRA11_HUMAN	keratin associated protein 1-1	123						extracellular region|keratin filament				NS(2)|endometrium(2)|kidney(5)|lung(4)|prostate(1)	14		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			CCTCCACACGGCAGTCTGGGC	0.677000													7	26					0	0	1	0	0
LOC150776	150776	broad.mit.edu	37	2	132266282	132266282	+	RNA	DEL	G	G	-	rs74537446		TCGA-QR-A6H3-01A-11D-A35D-08	TCGA-QR-A6H3-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fdebdcda-b632-47d0-b0d1-b6b88e9e06c8	2b45c73f-cb97-478e-8b4b-9b71354dd075	g.chr2:132266282delG	ENST00000438378.2	+	0	1234					NR_026922.1																						GCTGGATGGTGGGAAGCAGAA	0.547													4	5	---	---	---	---