Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RASGRP2	10235	broad.mit.edu	37	11	64494798	64494798	+	Missense_Mutation	SNP	A	A	T			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr11:64494798A>T	ENST00000377494.1	-	15	2731	c.1809T>A	c.(1807-1809)gaT>gaA	p.D603E	RASGRP2_ENST00000377497.3_Missense_Mutation_p.D602E|RASGRP2_ENST00000394432.3_Missense_Mutation_p.D602E|RASGRP2_ENST00000354024.3_Missense_Mutation_p.D602E			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	602					platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CAAACACCCCATCCTCCACCG	0.592000													4	80					0	0	1	0	0
GBA	2629	broad.mit.edu	37	1	155207218	155207218	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr1:155207218G>A	ENST00000428024.2	-	6	1154	c.652C>T	c.(652-654)Cct>Tct	p.P218S	GBA_ENST00000327247.5_Missense_Mutation_p.P305S|GBA_ENST00000427500.2_Missense_Mutation_p.P256S|GBA_ENST00000536770.1_Missense_Mutation_p.P192S|GBA_ENST00000368373.3_Missense_Mutation_p.P305S	NM_001171811.1	NP_001165282.1	P04062	GLCM_HUMAN	glucosidase, beta, acid	305					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	26	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	GCGAGGGTAGGACCTAGGTCA	0.572000									Gaucher disease type I				14	40					0	0	1	0	0
KLHL42	57542	broad.mit.edu	37	12	27950726	27950726	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr12:27950726G>A	ENST00000381271.2	+	3	1456	c.1145G>A	c.(1144-1146)cGc>cAc	p.R382H		NM_020782.1	NP_065833.1			kelch-like family member 42																		GTCCACATTCGCAAGCAGCAG	0.542000													6	279					0	0	1	0	0
DMC1	11144	broad.mit.edu	37	22	38916082	38916082	+	Silent	SNP	A	A	T			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr22:38916082A>T	ENST00000216024.2	-	14	1242	c.966T>A	c.(964-966)ccT>ccA	p.P322P	DMC1_ENST00000428462.2_Silent_p.P267P	NM_007068.2	NP_008999.2	Q14565	DMC1_HUMAN	DNA meiotic recombinase 1	322					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11	Melanoma(58;0.0286)					CTTCATTTTCAGGCATCTCAG	0.403000								Homologous recombination					3	53					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38643532	38643532	+	Missense_Mutation	SNP	G	G	C			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr19:38643532G>C	ENST00000222345.6	+	13	4095	c.3586G>C	c.(3586-3588)Gat>Cat	p.D1196H		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1196					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CTTCAGCCACGATGGGACGTC	0.632000													5	137					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3214432	3214432	+	Missense_Mutation	SNP	T	T	G			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr4:3214432T>G	ENST00000355072.5	+	49	6915	c.6770T>G	c.(6769-6771)cTt>cGt	p.L2257R		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2257					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GTGGCAACCCTTGAGGTAAGA	0.527000													4	62					0	0	1	0	0
HIST1H2BD	3017	broad.mit.edu	37	6	26158564	26158564	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr6:26158564C>G	ENST00000289316.2	+	1	191	c.167C>G	c.(166-168)tCt>tGt	p.S56C	HIST1H2BD_ENST00000377777.4_Missense_Mutation_p.S56C	NM_138720.2	NP_619790.1	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	56					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	24						ACCGGCATCTCTTCCAAGGCA	0.567000													4	223					0	0	1	0	0
THAP7-AS1	439931	broad.mit.edu	37	22	21363349	21363349	+	RNA	SNP	A	A	G			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr22:21363349A>G	ENST00000452284.1	+	0	1016				TUBA3FP_ENST00000422086.1_RNA|THAP7-AS1_ENST00000436079.1_RNA	NR_027051.1																						TATGGCACCAAGTTGGTTTGG	0.582000													4	58					0	0	1	0	0
MTM1	4534	broad.mit.edu	37	X	149807485	149807485	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chrX:149807485G>A	ENST00000370396.2	+	7	568	c.514G>A	c.(514-516)Gaa>Aaa	p.E172K	MTM1_ENST00000306167.7_3'UTR|MTM1_ENST00000542741.1_Missense_Mutation_p.E77K|MTM1_ENST00000413012.2_Missense_Mutation_p.E135K|MTM1_ENST00000543350.1_Missense_Mutation_p.E57K	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	172	Myotubularin phosphatase.				endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGTGGAAGAATACAGGAG	0.353000													4	141					0	0	1	0	0
MAP1S	55201	broad.mit.edu	37	19	17831773	17831773	+	Silent	SNP	C	C	T			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr19:17831773C>T	ENST00000324096.4	+	2	298	c.147C>T	c.(145-147)ggC>ggT	p.G49G	MAP1S_ENST00000544059.2_Silent_p.G23G|MAP1S_ENST00000597681.1_Intron	NM_018174.4	NP_060644.4	Q66K74	MAP1S_HUMAN	microtubule-associated protein 1S	49	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	25						TCGATCCTGGCGTCTGCAACC	0.572000													10	176					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232433	71232433	+	Missense_Mutation	SNP	C	C	T			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr17:71232433C>T	ENST00000359042.2	+	3	1006	c.812C>T	c.(811-813)cCa>cTa	p.P271L	C17orf80_ENST00000426147.2_Missense_Mutation_p.P271L|FAM104A_ENST00000583178.1_Intron|C17orf80_ENST00000577615.1_Missense_Mutation_p.P271L|C17orf80_ENST00000582793.1_Intron|C17orf80_ENST00000255557.4_Missense_Mutation_p.P271L|C17orf80_ENST00000268942.8_Missense_Mutation_p.P271L|C17orf80_ENST00000535032.2_Missense_Mutation_p.P271L	NM_017941.4	NP_060411.2	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	271						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			ACTGAGACTCCAGAAAAGAAC	0.413000													3	32					0	0	1	0	0
OR1J1	347168	broad.mit.edu	37	9	125239396	125239396	+	Silent	SNP	C	C	T			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr9:125239396C>T	ENST00000259357.2	-	1	839	c.810G>A	c.(808-810)aaG>aaA	p.K270K		NM_001004451.1	NP_001004451.1	Q8NGS3	OR1J1_HUMAN	olfactory receptor, family 1, subfamily J, member 1	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	16						CAATTATGTTCTTGTCATTGG	0.418000													4	166					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24104120	24104120	+	Missense_Mutation	SNP	G	G	T			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr16:24104120G>T	ENST00000303531.7	+	6	690	c.538G>T	c.(538-540)Gct>Tct	p.A180S	PRKCB_ENST00000321728.7_Missense_Mutation_p.A180S|PRKCB_ENST00000482000.1_3'UTR	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	180	C2.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	AGTAAGAGATGCTAAAAACCT	0.418000													5	115					0.000602214	0.00062298	1	1	0
LEPREL1	55214	broad.mit.edu	37	3	189704595	189704595	+	Silent	SNP	C	C	A			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr3:189704595C>A	ENST00000319332.5	-	6	1367	c.1170G>T	c.(1168-1170)ggG>ggT	p.G390G	LEPREL1_ENST00000427335.2_Silent_p.G209G	NM_018192.3	NP_060662.2	Q8IVL5	P3H2_HUMAN	leprecan-like 1	390					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(5)	41	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGTATGAAAACCCCAGACCTT	0.353000													10	173					7.03913e-09	7.82125e-09	1	1	0
TRO	7216	broad.mit.edu	37	X	54949634	54949634	+	Silent	SNP	G	G	A			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chrX:54949634G>A	ENST00000173898.7	+	3	781	c.669G>A	c.(667-669)tcG>tcA	p.S223S	TRO_ENST00000375022.4_Silent_p.S223S|TRO_ENST00000375041.2_Intron|TRO_ENST00000420798.2_Intron|TRO_ENST00000484031.1_Intron|TRO_ENST00000319167.8_Silent_p.S223S|TRO_ENST00000399736.1_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	223					embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						CCGAGGTCTCGCTGGCTGCAA	0.522000													3	28					0	0	1	0	0
OR4K15	81127	broad.mit.edu	37	14	20444562	20444562	+	Silent	SNP	T	T	G			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr14:20444562T>G	ENST00000305051.5	+	1	960	c.885T>G	c.(883-885)ctT>ctG	p.L295L		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ACAAAGTCCTTGCTGTATTCT	0.418000													4	133					0	0	1	0	0
AP4M1	9179	broad.mit.edu	37	7	99701079	99701079	+	Silent	SNP	C	C	T			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr7:99701079C>T	ENST00000429084.1	+	5	578	c.420C>T	c.(418-420)ttC>ttT	p.F140F	AP4M1_ENST00000421755.1_Silent_p.F133F|AP4M1_ENST00000422582.1_Silent_p.F5F|AP4M1_ENST00000359593.4_Silent_p.F133F			O00189	AP4M1_HUMAN	adaptor-related protein complex 4, mu 1 subunit	133					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|coated pit|Golgi trans cisterna	transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TGAGGAATTTCATCCAGACGG	0.517000													4	93					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	2017138	2017138	+	Silent	SNP	G	G	A			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr12:2017138G>A	ENST00000382722.5	-	5	914	c.552C>T	c.(550-552)ggC>ggT	p.G184G	CACNA2D4_ENST00000586184.1_Silent_p.G184G|CACNA2D4_ENST00000587995.1_Silent_p.G184G|CACNA2D4_ENST00000585732.1_Silent_p.G184G|CACNA2D4_ENST00000585708.1_Silent_p.G120G|CACNA2D4_ENST00000588077.1_Silent_p.G120G	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	184						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GGAACTCGGCGCCCAGCTCCA	0.602000													4	68					0	0	1	0	0
TRPM1	4308	broad.mit.edu	37	15	31342749	31342749	+	Missense_Mutation	SNP	C	C	A			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr15:31342749C>A	ENST00000542188.1	-	11	1664	c.1351G>T	c.(1351-1353)Gcc>Tcc	p.A451S	TRPM1_ENST00000256552.6_Missense_Mutation_p.A434S|TRPM1_ENST00000397795.2_Missense_Mutation_p.A412S	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	412					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTCTCCGTGGCTTTGCTGTCC	0.557000													3	39					0.115264	0.115264	1	1	0
CAMTA1	23261	broad.mit.edu	37	1	7725039	7725039	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr1:7725039G>A	ENST00000303635.7	+	9	2639	c.2432G>A	c.(2431-2433)cGg>cAg	p.R811Q	CAMTA1_ENST00000439411.2_Missense_Mutation_p.R811Q	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	811					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GACGGGGCGCGGGCCCCCTTC	0.687000			T	WWTR1	epitheliod hemangioendothelioma								6	160					0	0	1	0	0
ZNF599	148103	broad.mit.edu	37	19	35251041	35251041	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr19:35251041G>A	ENST00000329285.7	-	4	1038	c.665C>T	c.(664-666)gCt>gTt	p.A222V		NM_001007248.2	NP_001007249.1	Q96NL3	ZN599_HUMAN	zinc finger protein 599	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|skin(1)	24	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			CTTCACTCCAGCATGAATCTG	0.478000													4	180					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70818186	70818186	+	Missense_Mutation	SNP	A	A	G			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr5:70818186A>G	ENST00000358731.4	+	23	5325	c.5062A>G	c.(5062-5064)Aat>Gat	p.N1688D	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	1688					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GGCTAAGCCAAATTTGGGAAG	0.383000													4	174					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77258626	77258626	+	Missense_Mutation	SNP	C	C	G			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chrX:77258626C>G	ENST00000341514.6	+	6	1755	c.1600C>G	c.(1600-1602)Cct>Gct	p.P534A	ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000343533.5_Missense_Mutation_p.P534A	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	534	HMA 5.				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						AAGGTATAATCCTGCTGTTAT	0.393000													9	313					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	66982411	66982411	+	Missense_Mutation	SNP	G	G	A			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr17:66982411G>A	ENST00000340001.4	-	32	4313	c.4102C>T	c.(4102-4104)Cct>Tct	p.P1368S	ABCA9_ENST00000453985.2_Missense_Mutation_p.P1330S|ABCA9_ENST00000370732.2_Missense_Mutation_p.P1368S	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	1368	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TTCTCCTGAGGGCAGTACCCC	0.537000													18	56					0	0	1	0	0
RFPL1	5988	broad.mit.edu	37	22	29837976	29837976	+	Silent	SNP	C	C	A			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr22:29837976C>A	ENST00000354373.2	+	2	1028	c.819C>A	c.(817-819)gtC>gtA	p.V273V	RFPL1S_ENST00000461286.2_RNA	NM_021026.2	NP_066306.2	O75677	RFPL1_HUMAN	ret finger protein-like 1	273	B30.2/SPRY.						zinc ion binding	p.V273V(2)		endometrium(3)|large_intestine(1)|lung(6)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	16						TCAGGAGTGTCTCTGCTGAGG	0.468000													4	63					3.59834e-05	3.85536e-05	1	1	0
HSPD1P6	645548	broad.mit.edu	37	3	36810381	36810382	+	RNA	DEL	TT	TT	-			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr3:36810381_36810382delTT	ENST00000424886.1	-	0	404_405																											GAGTGAGGCCttttttttttta	0.545													2	4	---	---	---	---					
AGAP11	119385	broad.mit.edu	37	10	88767683	88767683	+	RNA	DEL	A	A	-	rs72036564		TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr10:88767683delA	ENST00000444431.1	+	0	2711				RP11-96C23.14_ENST00000444180.3_RNA|RP11-96C23.5_ENST00000433214.2_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										CAGAAAATGTATCtttttttt	0.413													2	4	---	---	---	---					
ADAMTS8	11095	broad.mit.edu	37	11	130297993	130297993	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr11:130297993delG	ENST00000257359.6	-	1	895	c.189delC	c.(187-189)ggfs	p.G63fs		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	63					negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GCAGCACGAAGCCCTTGCCGA	0.776													2	4	---	---	---	---					
DBNDD1	79007	broad.mit.edu	37	16	90072754	90072754	+	Frame_Shift_Del	DEL	G	G	-			TCGA-QR-A706-01A-11D-A35D-08	TCGA-QR-A706-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3eb85fa4-db21-4218-99c8-13f214d68222	8a2d6255-25ae-463f-98ab-eeb976337d81	g.chr16:90072754delG	ENST00000392973.3	-	3	1215	c.484delC	c.(484-486)agfs	p.Q162fs	DBNDD1_ENST00000304733.3_Frame_Shift_Del_p.Q176fs|DBNDD1_ENST00000568838.1_Frame_Shift_Del_p.Q276fs|DBNDD1_ENST00000002501.6_Frame_Shift_Del_p.Q156fs			Q9H9R9	DBND1_HUMAN	dysbindin (dystrobrevin binding protein 1) domain containing 1	156						cytoplasm				kidney(1)|large_intestine(1)|lung(1)	3		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0275)		TAGTCCTCCTGGGGCCTCTCC	0.637													2	4	---	---	---	---