Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PPP1R26	9858	broad.mit.edu	37	9	138376461	138376461	+	Silent	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr9:138376461C>T	ENST00000356818.2	+	4	654	c.105C>T	c.(103-105)gaC>gaT	p.D35D	PPP1R26_ENST00000605660.1_Silent_p.D35D|PPP1R26_ENST00000605286.1_Silent_p.D35D|PPP1R26_ENST00000604351.1_Silent_p.D35D|PPP1R26_ENST00000401470.3_Silent_p.D35D|PPP1R26_ENST00000602993.1_Intron	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	35						nucleolus	protein binding										CGGAGGCTGACGAGGGCGTGG	0.657000													29	56					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43415485	43415485	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr6:43415485C>T	ENST00000244533.3	+	16	4044	c.3685C>T	c.(3685-3687)Cca>Tca	p.P1229S	ABCC10_ENST00000372530.4_Missense_Mutation_p.P1257S	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	1257						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GGCGTACCGGCCAGGGCTGCC	0.662000													110	127					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162132	90162132	+	RNA	SNP	C	C	T	rs41303771		TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr16:90162132C>T	ENST00000567960.1	+	0	868				TUBB8P7_ENST00000564451.1_RNA																							TGGCTGAGCTCACCCAGCAGA	0.607000													5	85					0	0	1	0	0
ATP1B1	481	broad.mit.edu	37	1	169100776	169100776	+	Missense_Mutation	SNP	A	A	G			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr1:169100776A>G	ENST00000367816.1	+	7	1424	c.895A>G	c.(895-897)Att>Gtt	p.I299V	ATP1B1_ENST00000499679.3_Missense_Mutation_p.I243V|ATP1B1_ENST00000367815.3_Missense_Mutation_p.I299V|ATP1B1_ENST00000367813.3_Missense_Mutation_p.I291V			P05026	AT1B1_HUMAN	ATPase, Na+/K+ transporting, beta 1 polypeptide	299					ATP biosynthetic process|blood coagulation|leukocyte migration	sodium:potassium-exchanging ATPase complex	protein binding|sodium:potassium-exchanging ATPase activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	14	all_hematologic(923;0.208)					TGATGTAAAAATTGAAGTTAA	0.368000													5	101					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													3	41					0	0	1	0	0
IL16	3603	broad.mit.edu	37	15	81575036	81575036	+	Missense_Mutation	SNP	T	T	A			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr15:81575036T>A	ENST00000394660.2	+	9	1498	c.1138T>A	c.(1138-1140)Tct>Act	p.S380T	IL16_ENST00000302987.4_Missense_Mutation_p.S380T	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	380	Interaction with GRIN2A.|PDZ 2.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						CCAATGCATCTCTGGCATTTT	0.607000													5	202					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45262355	45262355	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr5:45262355G>A	ENST00000303230.4	-	8	2398	c.2341C>T	c.(2341-2343)Cgg>Tgg	p.R781W		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	781						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity	p.R781R(1)		NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CTGACTTCCCGGGTCAGGTTG	0.637000													13	43					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76855943	76855943	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chrX:76855943G>A	ENST00000373344.5	-	23	5871	c.5657C>T	c.(5656-5658)cCt>cTt	p.P1886L	ATRX_ENST00000395603.3_Missense_Mutation_p.P1848L|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1886					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	CAAACACCAAGGATGAGTCCA	0.363000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						175	302					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29840161	29840161	+	Missense_Mutation	SNP	A	A	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr10:29840161A>T	ENST00000375398.2	-	8	641	c.192T>A	c.(190-192)gaT>gaA	p.D64E	SVIL_ENST00000355867.4_Missense_Mutation_p.D64E|SVIL_ENST00000375400.3_Missense_Mutation_p.D64E			O95425	SVIL_HUMAN	supervillin	64	Interaction with MYLK (By similarity).				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CTAGAGAAGAATCAGAAGTTT	0.458000													17	39					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553676	140553676	+	Silent	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr5:140553676C>T	ENST00000231137.3	+	1	1434	c.1260C>T	c.(1258-1260)acC>acT	p.T420T		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		420	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAACATCACCATCACCGTCA	0.512000													4	108					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18846098	18846098	+	RNA	SNP	G	G	A	rs9306211		TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr22:18846098G>A	ENST00000412938.1	+	0	3456																											ATGCCTCGGCGCTCGATCTCC	0.622000													4	28					0	0	1	0	0
TBC1D32	221322	broad.mit.edu	37	6	121491568	121491568	+	Silent	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr6:121491568C>T	ENST00000275159.6	-	23	2675	c.2676G>A	c.(2674-2676)gaG>gaA	p.E892E	TBC1D32_ENST00000398212.2_Intron|TBC1D32_ENST00000398197.2_Intron					TBC1 domain family, member 32																		TCTCAGAAATCTCCAAGATAT	0.353000													14	44					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100391825	100391825	+	RNA	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr7:100391825C>T	ENST00000542585.1	+	0	8280				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGCCCTTCAGCTGCAGAGCGG	0.637000													33	36					0	0	1	0	0
GPR132	29933	broad.mit.edu	37	14	105517581	105517581	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr14:105517581G>A	ENST00000329797.3	-	4	1804	c.893C>T	c.(892-894)aCg>aTg	p.T298M	GPR132_ENST00000392585.2_Missense_Mutation_p.T289M|GPR132_ENST00000539291.2_Missense_Mutation_p.T298M	NM_013345.2	NP_037477.1	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	298					response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	18		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		GCCGTTCACCGTGGACAGGCA	0.562000													13	41					0	0	1	0	0
RBM12B	389677	broad.mit.edu	37	8	94747087	94747087	+	Missense_Mutation	SNP	T	T	C			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr8:94747087T>C	ENST00000399300.2	-	3	1765	c.1552A>G	c.(1552-1554)Ata>Gta	p.I518V	RBM12B_ENST00000517700.1_Missense_Mutation_p.I518V|RBM12B_ENST00000520961.1_Intron	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	518							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			ACTGAGTATATTGGTGGGTCT	0.443000													38	120					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68965465	68965465	+	Missense_Mutation	SNP	A	A	C			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr8:68965465A>C	ENST00000288368.4	+	9	1354	c.1077A>C	c.(1075-1077)gaA>gaC	p.E359D	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	359	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TTTTGAAAGAAAGAGAACGGC	0.378000													17	116					0	0	1	0	0
KCNA6	3742	broad.mit.edu	37	12	4919742	4919742	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr12:4919742G>A	ENST00000433855.1	+	1	1401	c.535G>A	c.(535-537)Gtc>Atc	p.V179I	KCNA6_ENST00000280684.3_Missense_Mutation_p.V179I	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	179						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.V179I(1)		NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						CATCGCCATCGTCTCCGTGTT	0.592000										HNSCC(72;0.22)			27	43					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42162707	42162707	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr20:42162707G>A	ENST00000444063.1	+	11	1435	c.1303G>A	c.(1303-1305)Gct>Act	p.A435T	L3MBTL1_ENST00000373135.3_Missense_Mutation_p.A435T|L3MBTL1_ENST00000427442.2_Missense_Mutation_p.A503T|L3MBTL1_ENST00000373134.1_Missense_Mutation_p.A435T|L3MBTL1_ENST00000418998.1_Missense_Mutation_p.A503T			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	435					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						TGGGGCCTCTGCTGTCCCCAC	0.572000													4	92					0	0	1	0	0
LCA5L	150082	broad.mit.edu	37	21	40781999	40781999	+	Silent	SNP	G	G	A			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr21:40781999G>A	ENST00000358268.2	-	9	1716	c.1188C>T	c.(1186-1188)atC>atT	p.I396I	LCA5L_ENST00000380671.2_Silent_p.I396I|LCA5L_ENST00000495240.1_5'UTR|LCA5L_ENST00000288350.3_Silent_p.I396I|WRB_ENST00000541890.1_Intron			O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	396										breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	24		Prostate(19;1.2e-06)				CTTTATGATCGATGTTTCCTG	0.308000													33	64					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62370926	62370926	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr8:62370926C>T	ENST00000519846.1	+	6	1274	c.802C>T	c.(802-804)Ccc>Tcc	p.P268S	CLVS1_ENST00000325897.4_Missense_Mutation_p.P268S|CLVS1_ENST00000518592.1_5'UTR			Q8IUQ0	CLVS1_HUMAN	clavesin 1	268	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity	p.P268S(1)		endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						TGAATTTTTGCCCTCTGAATT	0.413000													4	141					0	0	1	0	0
POLD2	5425	broad.mit.edu	37	7	44154459	44154459	+	Silent	SNP	C	C	G			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr7:44154459C>G	ENST00000406581.2	-	12	1984	c.1335G>C	c.(1333-1335)ctG>ctC	p.L445L	POLD2_ENST00000452185.1_Silent_p.L445L|POLD2_ENST00000223361.3_Silent_p.L431L	NM_001256879.1	NP_001243808.1	P49005	DPOD2_HUMAN	polymerase (DNA directed), delta 2, accessory subunit	445					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	12						GCTGGCAGGCCAGGCTGCGCA	0.612000													10	18					0	0	1	0	0
CD1B	910	broad.mit.edu	37	1	158300810	158300810	+	Missense_Mutation	SNP	G	G	C			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr1:158300810G>C	ENST00000368168.3	-	2	211	c.104C>G	c.(103-105)tCc>tGc	p.S35C		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	35					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					ATTGGTAAAGGACGAGGTCTG	0.493000													15	355					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235940409	235940409	+	Missense_Mutation	SNP	A	A	G			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr1:235940409A>G	ENST00000389794.3	-	17	5588	c.5414T>C	c.(5413-5415)cTg>cCg	p.L1805P	LYST_ENST00000389793.2_Missense_Mutation_p.L1805P|LYST_ENST00000536965.1_3'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1805					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AATTTCGTGCAGAATGCCTTG	0.353000													8	116					0	0	1	0	0
G6PC3	92579	broad.mit.edu	37	17	42153351	42153351	+	Silent	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr17:42153351C>T	ENST00000269097.4	+	6	1212	c.981C>T	c.(979-981)ctC>ctT	p.L327L		NM_138387.3	NP_612396.1	Q9BUM1	G6PC3_HUMAN	glucose 6 phosphatase, catalytic, 3	327					gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			endometrium(2)|large_intestine(5)|lung(1)|ovary(2)|skin(1)	11		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)		TCCTGGCCCTCGTGCCCTGGG	0.592000													16	152					0	0	1	0	0
NOMO2	283820	broad.mit.edu	37	16	18532210	18532210	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr16:18532210C>T	ENST00000330537.6	-	19	2320	c.2150G>A	c.(2149-2151)cGc>cAc	p.R717H	NOMO2_ENST00000381474.3_Missense_Mutation_p.R717H|NOMO2_ENST00000543392.1_Missense_Mutation_p.R550H	NM_173614.2	NP_775885.1	Q5JPE7	NOMO2_HUMAN	NODAL modulator 2	717						endoplasmic reticulum membrane|integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(2)|liver(3)|lung(5)|ovary(3)|prostate(1)|skin(1)	20						CTCCTGCCTGCGGGCCTCGAT	0.572000													4	147					0	0	1	0	0
SPATA13	221178	broad.mit.edu	37	13	24858319	24858319	+	Silent	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr13:24858319C>T	ENST00000424834.2	+	7	2684	c.2211C>T	c.(2209-2211)aaC>aaT	p.N737N	SPATA13_ENST00000399949.2_Silent_p.N34N|SPATA13_ENST00000382108.3_Silent_p.N737N|SPATA13_ENST00000382095.4_Silent_p.N112N|SPATA13_ENST00000343003.6_Silent_p.N56N|SPATA13_ENST00000409126.1_Silent_p.N34N			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	112					cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		TGGATGACAACGgtagtgagg	0.493000													4	54					0	0	1	0	0
RPGR	6103	broad.mit.edu	37	X	38156540	38156540	+	Missense_Mutation	SNP	G	G	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chrX:38156540G>T	ENST00000378505.2	-	11	1587	c.1411C>A	c.(1411-1413)Cca>Aca	p.P471T	RPGR_ENST00000339363.3_Missense_Mutation_p.P471T|RPGR_ENST00000318842.7_Missense_Mutation_p.P471T|RPGR_ENST00000342811.3_Missense_Mutation_p.P471T|RPGR_ENST00000338898.3_Missense_Mutation_p.P471T|TM4SF2_ENST00000465127.1_Intron|RPGR_ENST00000309513.3_Missense_Mutation_p.P409T	NM_001034853.1	NP_001030025.1	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator	471					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	25						ATGTTACCTGGTTCCTCTGGC	0.393000													7	97					0.0381472	0.0389949	1	1	0
MAGEC1	9947	broad.mit.edu	37	X	140996020	140996020	+	Missense_Mutation	SNP	G	G	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chrX:140996020G>T	ENST00000285879.4	+	4	3116	c.2830G>T	c.(2830-2832)Ggc>Tgc	p.G944C	MAGEC1_ENST00000406005.2_Missense_Mutation_p.G11C	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	944	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CAGGTACACGGGCTACTTTCC	0.473000										HNSCC(15;0.026)			116	161					9.53958e-58	1.07029e-57	1	1	0
COL24A1	255631	broad.mit.edu	37	1	86210382	86210382	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr1:86210382C>T	ENST00000370571.2	-	57	5005	c.4639G>A	c.(4639-4641)Gat>Aat	p.D1547N	COL24A1_ENST00000436319.1_Missense_Mutation_p.D1526N	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1547	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TTAAGTAAATCTTTGCAGATT	0.368000													58	39					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143018823	143018823	+	Missense_Mutation	SNP	A	A	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr7:143018823A>T	ENST00000343257.2	+	5	665	c.578A>T	c.(577-579)gAa>gTa	p.E193V	CLCN1_ENST00000495612.1_3'UTR	NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	193					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GGAATCCCCGAAATGAAGACA	0.498000													50	87					0	0	1	0	0
KRT74	121391	broad.mit.edu	37	12	52967343	52967343	+	Silent	SNP	G	G	A			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr12:52967343G>A	ENST00000549343.1	-	1	257	c.219C>T	c.(217-219)taC>taT	p.Y73Y	KRT74_ENST00000305620.2_Silent_p.Y73Y			Q7RTS7	K2C74_HUMAN	keratin 74	73	Gly-rich.|Head.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		GCCTGAAGCCGTAACCTCCAG	0.617000													17	43					0	0	1	0	0
OR2W5	441932	broad.mit.edu	37	1	247654533	247654533	+	RNA	SNP	G	G	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr1:247654533G>T	ENST00000522351.1	+	0	164							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TTGATCTTCTGCATCCTGACC	0.498000													19	53					1.00905e-13	1.10515e-13	1	1	0
RBP3	5949	broad.mit.edu	37	10	48390173	48390173	+	Silent	SNP	G	G	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr10:48390173G>T	ENST00000224600.4	-	1	818	c.705C>A	c.(703-705)acC>acA	p.T235T		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	235	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	CCACGCCCCTGGTCTGGCTGC	0.667000													6	49					0.217242	0.217242	1	1	0
CD300LB	124599	broad.mit.edu	37	17	72522084	72522084	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr17:72522084C>T	ENST00000392621.1	-	2	288	c.284G>A	c.(283-285)tGc>tAc	p.C95Y	CD300LB_ENST00000314401.3_Missense_Mutation_p.C95Y	NM_174892.2	NP_777552.2	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	58	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(1)	21						GAGGATCTTGCATGTATCCCA	0.542000													25	198					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20952798	20952798	+	Missense_Mutation	SNP	A	A	G			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr16:20952798A>G	ENST00000261383.3	-	59	11578	c.11579T>C	c.(11578-11580)gTc>gCc	p.V3860A	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3860					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CAACTTCATGACCTCTTCCAG	0.478000													96	147					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55279581	55279581	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr1:55279581C>T	ENST00000358193.3	+	7	911	c.857C>T	c.(856-858)cCc>cTc	p.P286L	C1orf177_ENST00000371273.3_Missense_Mutation_p.P286L	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	286										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						TCTAAACTTCCCCGAAACCCG	0.473000													35	45					0	0	1	0	0
AKAP12	9590	broad.mit.edu	37	6	151672064	151672064	+	Silent	SNP	G	G	A			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr6:151672064G>A	ENST00000402676.2	+	4	2778	c.2538G>A	c.(2536-2538)gtG>gtA	p.V846V	AKAP12_ENST00000359755.5_Silent_p.V741V|AKAP12_ENST00000354675.6_Silent_p.V748V|AKAP12_ENST00000253332.1_Silent_p.V846V	NM_005100.3	NP_005091.2	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12	846					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	68		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		TCCCGGCCGTGGTCCCTCTGT	0.557000													60	90					0	0	1	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|HLA-J_ENST00000462773.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													4	107					0	0	1	0	0
OR2J3	442186	broad.mit.edu	37	6	29080275	29080275	+	Missense_Mutation	SNP	T	T	C			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr6:29080275T>C	ENST00000377169.1	+	1	608	c.608T>C	c.(607-609)aTg>aCg	p.M203T		NM_001005216.2	NP_001005216.2	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J, member 3	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24						CTGACCCTCATGATCACAAGC	0.473000													10	78					0	0	1	0	0
AURKC	6795	broad.mit.edu	37	19	57743156	57743156	+	Splice_Site	SNP	G	G	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr19:57743156G>T	ENST00000302804.7	+	2	290		c.e2+1		AURKC_ENST00000448930.1_Splice_Site|AURKC_ENST00000415300.2_Splice_Site|AURKC_ENST00000599062.1_Splice_Site|AURKC_ENST00000598785.1_Splice_Site	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C						cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		gcccagcCATGTGAGTCCCTT	0.577000													10	96					1.76689e-08	1.89017e-08	1	1	0
FLG2	388698	broad.mit.edu	37	1	152324558	152324559	+	Frame_Shift_Del	DEL	TG	TG	-	rs140875805	byFrequency	TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr1:152324558_152324559delTG	ENST00000388718.5	-	3	5775_5776	c.5703_5704delCA	c.(5701-5706)cagcfs	p.HS1901fs	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1901							calcium ion binding|structural molecule activity	p.H1901fs*30(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGCTTGGCTGTGTGTGTGTC	0.515													8	484	---	---	---	---					
AC016995.3	0	broad.mit.edu	37	2	38710017	38710019	+	RNA	DEL	AAT	AAT	-	rs2005502	by1000genomes	TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr2:38710017_38710019delAAT	ENST00000417039.1	-	0	696																											TTCTTtaaaaaataaataaataa	0.246													5	10	---	---	---	---					
PGM2	55276	broad.mit.edu	37	4	37836301	37836301	+	Frame_Shift_Del	DEL	G	G	-			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr4:37836301delG	ENST00000381967.4	+	3	411	c.311delG	c.(310-312)atfs	p.S104fs	PGM2_ENST00000537241.1_Intron|PGM2_ENST00000544359.1_5'UTR	NM_018290.3	NP_060760.2	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	104					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			breast(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|urinary_tract(1)	19						ATCGTGATCAGTTTTGACGCC	0.338													12	143	---	---	---	---					
TCP11	6954	broad.mit.edu	37	6	35108990	35108990	+	Frame_Shift_Del	DEL	C	C	-			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr6:35108990delC	ENST00000311875.5	-	1	434	c.17delG	c.(16-18)gafs	p.G8fs	TCP11_ENST00000373974.4_Frame_Shift_Del_p.G8fs|TCP11_ENST00000510465.1_5'UTR|TCP11_ENST00000412155.2_Frame_Shift_Del_p.G9fs|TCP11_ENST00000373979.2_5'UTR|TCP11_ENST00000444780.2_Frame_Shift_Del_p.G8fs|TCP11_ENST00000244645.3_5'UTR|TCP11_ENST00000418521.2_Intron			Q8WWU5	TCP11_HUMAN	t-complex 11, testis-specific	0					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane		p.G6fs*56(1)		breast(1)|kidney(5)|large_intestine(3)|lung(10)|ovary(3)|prostate(1)|skin(4)	27						ACCTCCTCCTCCCCCGCCGCG	0.781													2	4	---	---	---	---					
STAG3L4	64940	broad.mit.edu	37	7	66767610	66767611	+	RNA	INS	-	-	G	rs71293166	by1000genomes	TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr7:66767610_66767611insG	ENST00000416602.2	+	0	3_4					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				CACCGGACTGCTTTTTTTTTTT	0.545													2	4	---	---	---	---					
PRTG	283659	broad.mit.edu	37	15	56032588	56032605	+	In_Frame_Del	DEL	GCAAGATGAGCTTTTTGA	GCAAGATGAGCTTTTTGA	-			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr15:56032588_56032605delGCAAGATGAGCTTTTTGA	ENST00000389286.4	-	2	419_436	c.372_389delTCAAAAAGCTCATCTTGC	c.(370-390)agc>ag	p.SQKAHLA124del	PRTG_ENST00000561292.1_In_Frame_Del_p.SQKAHLA124del	NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	124	Ig-like 1.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		ACTTGATAAGGCAAGATGAGCTTTTTGACTAAGAATGG	0.372													24	139	---	---	---	---					
ANKRD11	29123	broad.mit.edu	37	16	89349640	89349641	+	Frame_Shift_Ins	INS	-	-	T			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr16:89349640_89349641insT	ENST00000301030.4	-	9	3769_3770	c.3309_3310insA	c.(3307-3312)aaatgafs	p.*1104fs	ANKRD11_ENST00000378330.2_Frame_Shift_Ins_p.*1104fs	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1104	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTCTTGTCATCTTTTTTTTCAG	0.465													7	243	---	---	---	---					
LRRC75A-AS1	125144	broad.mit.edu	37	17	16344167	16344168	+	RNA	DEL	AA	AA	-	rs10587316		TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr17:16344167_16344168delAA	ENST00000475953.1	+	0	483				C17orf76-AS1_ENST00000583400.2_RNA|C17orf76-AS1_ENST00000477249.2_RNA|C17orf76-AS1_ENST00000475947.2_RNA|C17orf76-AS1_ENST00000480811.1_RNA|C17orf76-AS1_ENST00000581913.1_RNA|C17orf76-AS1_ENST00000483140.1_RNA|C17orf76-AS1_ENST00000481027.1_RNA|C17orf76-AS1_ENST00000584926.1_RNA|C17orf76-AS1_ENST00000470491.2_RNA|C17orf76-AS1_ENST00000492250.1_RNA|C17orf76-AS1_ENST00000481898.1_RNA|C17orf76-AS1_ENST00000460249.1_RNA|C17orf76-AS1_ENST00000491009.1_RNA|C17orf76-AS1_ENST00000579473.1_RNA|RP11-138I1.3_ENST00000585048.1_lincRNA|C17orf76-AS1_ENST00000484836.1_RNA|C17orf76-AS1_ENST00000584141.1_RNA|C17orf76-AS1_ENST00000584177.1_RNA|C17orf76-AS1_ENST00000582911.1_RNA|C17orf76-AS1_ENST00000487066.1_RNA|C17orf76-AS1_ENST00000580770.1_RNA|C17orf76-AS1_ENST00000580180.1_RNA|C17orf76-AS1_ENST00000581718.1_RNA|C17orf76-AS1_ENST00000472367.1_RNA|C17orf76-AS1_ENST00000478103.2_RNA	NR_027667.1																						actccatctcaaaaaaaaaaaa	0.411													2	4	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													9	54	---	---	---	---					
MEGF8	1954	broad.mit.edu	37	19	42874925	42874925	+	Frame_Shift_Del	DEL	G	G	-			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr19:42874925delG	ENST00000334370.4	+	39	7512	c.6877delG	c.(6877-6879)ggfs	p.G2293fs	MEGF8_ENST00000251268.6_Frame_Shift_Del_p.G2360fs|MEGF8_ENST00000378073.4_5'UTR	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2360	Laminin EGF-like 3.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				TAACAGCTATGGGGAGAAATG	0.602													2	4	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													4	5	---	---	---	---					
FAM83D	81610	broad.mit.edu	37	20	37555322	37555323	+	In_Frame_Ins	INS	-	-	GCG			TCGA-RW-A680-01A-11D-A35D-08	TCGA-RW-A680-10B-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	077f4d33-fea4-4312-895b-f518b45ca082	35b38d0c-514b-4879-939f-ffa2d8872058	g.chr20:37555322_37555323insGCG	ENST00000217429.4	+	1	368_369	c.327_328insGCG	c.(325-330)ggcggc>ggGCGcggc	p.109_110GG>GRG		NM_030919.2	NP_112181.2	Q9H4H8	FA83D_HUMAN	family with sequence similarity 83, member D	79					cell division|mitosis	cytoplasm|spindle pole				endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)|stomach(1)	28		Myeloproliferative disorder(115;0.00878)				GAGAGGAGGGCgcggcggcggc	0.718													4	2	---	---	---	---