Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FRMD4A	55691	broad.mit.edu	37	10	13712496	13712496	+	Silent	SNP	G	G	A			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr10:13712496G>A	ENST00000357447.2	-	17	1652	c.1284C>T	c.(1282-1284)ccC>ccT	p.P428P	FRMD4A_ENST00000358621.4_Silent_p.P413P|FRMD4A_ENST00000378503.1_Silent_p.P428P	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	428						cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						CTGGATCCAGGGGATATTCTA	0.517000													19	39					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31573040	31573040	+	Missense_Mutation	SNP	T	T	C			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr2:31573040T>C	ENST00000379416.3	-	25	2729	c.2681A>G	c.(2680-2682)aAc>aGc	p.N894S		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	894					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GCCCCGGATGTTGGGGATTTT	0.537000													14	58					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38781061	38781061	+	Missense_Mutation	SNP	A	A	G			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr3:38781061A>G	ENST00000449082.2	-	14	2224	c.2225T>C	c.(2224-2226)cTa>cCa	p.L742P		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	742					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GCCCAGCTCTAGCAGACTCAC	0.478000													17	25					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81741405	81741405	+	Silent	SNP	C	C	A			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr12:81741405C>A	ENST00000550584.2	-	17	2434	c.2139G>T	c.(2137-2139)ctG>ctT	p.L713L	PPFIA2_ENST00000548586.1_Silent_p.L713L|PPFIA2_ENST00000541570.2_Silent_p.L280L|PPFIA2_ENST00000552948.1_Silent_p.L713L|PPFIA2_ENST00000541017.1_Intron|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000550359.2_Silent_p.L560L|PPFIA2_ENST00000443686.3_Silent_p.L614L|PPFIA2_ENST00000549325.1_Silent_p.L695L|PPFIA2_ENST00000549396.1_Silent_p.L713L|PPFIA2_ENST00000407050.4_Silent_p.L639L|PPFIA2_ENST00000333447.7_Silent_p.L695L	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	639										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						ATGAACTGGCCAGCGATGAAG	0.532000													8	102					0.00621372	0.00648388	1	1	0
SMTN	6525	broad.mit.edu	37	22	31484930	31484930	+	Missense_Mutation	SNP	C	C	A			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr22:31484930C>A	ENST00000333137.7	+	6	664	c.446C>A	c.(445-447)gCg>gAg	p.A149E	SMTN_ENST00000347557.2_Missense_Mutation_p.A149E|SMTN_ENST00000358743.1_Missense_Mutation_p.A149E	NM_001207018.1|NM_134269.2	NP_001193947.1|NP_599031.1	P53814	SMTN_HUMAN	smoothelin	149					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						AAGGGGCTAGCGGCACACAGG	0.607000											OREG0026472	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	27					6.4e-05	6.98182e-05	1	1	0
GPR98	84059	broad.mit.edu	37	5	90074890	90074890	+	Missense_Mutation	SNP	T	T	G			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr5:90074890T>G	ENST00000405460.2	+	64	13154	c.13058T>G	c.(13057-13059)aTt>aGt	p.I4353S		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4353	Calx-beta 29.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCTCTAACAATTACAAAGGTG	0.423000													3	20					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158582669	158582669	+	Missense_Mutation	SNP	C	C	T			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr1:158582669C>T	ENST00000368148.3	-	51	7252	c.7072G>A	c.(7072-7074)Gag>Aag	p.E2358K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E2355K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2358	EF-hand 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AAGGCATTCTCTATTTCATCA	0.468000													12	30					0	0	1	0	0
RBM33	155435	broad.mit.edu	37	7	155503998	155503998	+	Silent	SNP	G	G	A			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr7:155503998G>A	ENST00000401878.3	+	8	1248	c.1050G>A	c.(1048-1050)ccG>ccA	p.P350P	RBM33_ENST00000486747.1_3'UTR	NM_053043.2	NP_444271.2	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	350	Pro-rich.						nucleotide binding|RNA binding			breast(3)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	27	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		TGCAGCACCCGCACCACCCAT	0.682000													3	34					0	0	1	0	0
TLE1	7088	broad.mit.edu	37	9	84228341	84228341	+	Silent	SNP	A	A	G			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr9:84228341A>G	ENST00000376499.3	-	12	2078	c.1014T>C	c.(1012-1014)cgT>cgC	p.R338R	TLE1_ENST00000376472.1_Silent_p.R13R|TLE1_ENST00000376484.1_Silent_p.R13R|TLE1_ENST00000464999.1_5'UTR	NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	338	Pro/Ser-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						CGAGACCTGGACGGAGGCCTG	0.592000													3	45					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70346370	70346370	+	Silent	SNP	C	C	T			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr4:70346370C>T	ENST00000305107.6	-	6	1615	c.1569G>A	c.(1567-1569)aaG>aaA	p.K523K	UGT2B4_ENST00000381096.3_Silent_p.K387K|UGT2B4_ENST00000512583.1_3'UTR|UGT2B4_ENST00000506580.1_5'UTR	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	523					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						TTTTCCCCTTCTTTCCTGTTC	0.408000													18	83					0	0	1	0	0
FGFR1	2260	broad.mit.edu	37	8	38274849	38274849	+	Missense_Mutation	SNP	G	G	T			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr8:38274849G>T	ENST00000447712.2	-	12	2579	c.1638C>A	c.(1636-1638)aaC>aaA	p.N546K	FGFR1_ENST00000532791.1_Missense_Mutation_p.N544K|FGFR1_ENST00000326324.6_Missense_Mutation_p.N455K|FGFR1_ENST00000425967.3_Missense_Mutation_p.N577K|FGFR1_ENST00000397091.5_Missense_Mutation_p.N544K|FGFR1_ENST00000397103.1_Missense_Mutation_p.N457K|FGFR1_ENST00000397108.4_Missense_Mutation_p.N544K|FGFR1_ENST00000397113.2_Missense_Mutation_p.N544K|FGFR1_ENST00000356207.5_Missense_Mutation_p.N457K|FGFR1_ENST00000341462.5_Missense_Mutation_p.N546K|FGFR1_ENST00000335922.5_Missense_Mutation_p.N536K	NM_001174063.1|NM_015850.3|NM_023110.2	NP_001167534.1|NP_056934.2|NP_075598.2	P11362	FGFR1_HUMAN	fibroblast growth factor receptor 1	546	Protein kinase.				axon guidance|cell growth|insulin receptor signaling pathway|MAPKKK cascade|positive regulation of cell proliferation|skeletal system development	extracellular region|integral to plasma membrane|membrane fraction	ATP binding|fibroblast growth factor receptor activity|heparin binding|protein homodimerization activity	p.N546K(4)	FGFR1/ZNF703(2)	breast(2)|central_nervous_system(7)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(18)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	50	all_cancers(2;9.05e-47)|all_epithelial(2;2.64e-50)|all_lung(3;1.71e-23)|Lung NSC(2;3.61e-23)|Colorectal(12;0.000442)	Breast(189;1.48e-05)|all_lung(54;0.00354)|Lung NSC(58;0.0138)|Hepatocellular(245;0.065)	Epithelial(3;3.96e-34)|all cancers(3;3.06e-30)|BRCA - Breast invasive adenocarcinoma(5;2.28e-21)|COAD - Colon adenocarcinoma(9;0.24)		Palifermin(DB00039)	CCCCCAGCAGGTTGATGATAT	0.542000		1	T	"""BCR, FOP, ZNF198, CEP1"""	"""MPD, NHL"""		"""Pfeiffer syndrome, Kallman syndrome"""						28	37					8.4185e-14	9.62115e-14	1	1	0
MAML1	9794	broad.mit.edu	37	5	179193112	179193112	+	Silent	SNP	A	A	C			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr5:179193112A>C	ENST00000292599.3	+	2	1364	c.1101A>C	c.(1099-1101)tcA>tcC	p.S367S	MAML1_ENST00000503050.1_3'UTR	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	367					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGCCGGCATCAGCCCAGGCCC	0.627000													5	44					0	0	1	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138201287	138201287	+	Silent	SNP	C	C	T			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr6:138201287C>T	ENST00000237289.4	+	8	2052	c.1986C>T	c.(1984-1986)tgC>tgT	p.C662C		NM_001270507.1|NM_001270508.1|NM_006290.3	NP_001257436.1|NP_001257437.1|NP_006281.1	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	662	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(25)|p.C662fs*36(1)		breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(196)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	225	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		GGAGGGAATGCGGCACCCTTG	0.502000			"""D, N, F"""		"""marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma"""								3	36					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24669920	24669920	+	Silent	SNP	T	T	C			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr10:24669920T>C	ENST00000376454.3	+	3	507	c.477T>C	c.(475-477)ccT>ccC	p.P159P	KIAA1217_ENST00000376462.1_Silent_p.P79P|KIAA1217_ENST00000458595.1_Silent_p.P159P|KIAA1217_ENST00000376452.3_Silent_p.P159P|KIAA1217_ENST00000430453.2_Silent_p.P80P	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	159					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CTCCAACCCCTTTTTCCAGAG	0.542000													3	54					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39990877	39990877	+	Silent	SNP	C	C	T			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr20:39990877C>T	ENST00000332312.3	-	4	1524	c.1332G>A	c.(1330-1332)ggG>ggA	p.G444G		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	444						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				CACCCTCTGTCCCATTGAGCG	0.667000													32	56					0	0	1	0	0
STOX1	219736	broad.mit.edu	37	10	70645882	70645882	+	Missense_Mutation	SNP	G	G	A			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr10:70645882G>A	ENST00000298596.6	+	3	2413	c.2330G>A	c.(2329-2331)aGa>aAa	p.R777K	STOX1_ENST00000399169.4_Missense_Mutation_p.R777K|STOX1_ENST00000399165.4_Intron|STOX1_ENST00000421961.2_Missense_Mutation_p.R667K|STOX1_ENST00000399162.2_Intron	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	777						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						GTGATTGAGAGATCTCTGACC	0.468000													4	47					0	0	1	0	0
TEK	7010	broad.mit.edu	37	9	27180335	27180335	+	Silent	SNP	A	A	G	rs111637971		TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr9:27180335A>G	ENST00000380036.4	+	7	1441	c.999A>G	c.(997-999)ccA>ccG	p.P333P	TEK_ENST00000406359.4_Intron|TEK_ENST00000519097.1_Intron	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	333	EGF-like 3.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TCTGCTCTCCAGGATGGCAGG	0.507000													9	17					0	0	1	0	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139477	90139477	+	RNA	SNP	G	G	A	rs2848291	by1000genomes	TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr2:90139477G>A	ENST00000492446.1	+	0	275																											GTCCCATCAAGGTTCAGCGGC	0.483000													4	157					0	0	1	0	0
REV1	51455	broad.mit.edu	37	2	100065882	100065882	+	Missense_Mutation	SNP	T	T	C			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr2:100065882T>C	ENST00000258428.3	-	4	494	c.266A>G	c.(265-267)cAt>cGt	p.H89R	REV1_ENST00000393445.3_Missense_Mutation_p.H89R|REV1_ENST00000465835.1_5'UTR	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	89	BRCT.				DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGCAATAATATGTGTTGTTTT	0.323000								Direct reversal of damage					4	78					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169454924	169454924	+	Nonsense_Mutation	SNP	G	G	T			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr5:169454924G>T	ENST00000256935.8	+	34	3519	c.3439G>T	c.(3439-3441)Gag>Tag	p.E1147*	DOCK2_ENST00000520908.1_Nonsense_Mutation_p.E639*|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Nonsense_Mutation_p.E208*	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1147	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCGAGGCGACGAGCAGTACAT	0.517000													5	94					0.217242	0.217242	1	1	0
ZMYM1	79830	broad.mit.edu	37	1	35579445	35579445	+	Missense_Mutation	SNP	G	G	C			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr1:35579445G>C	ENST00000373330.1	+	11	2188	c.2014G>C	c.(2014-2016)Gct>Cct	p.A672P	ZMYM1_ENST00000373329.1_3'UTR|ZMYM1_ENST00000359858.4_Missense_Mutation_p.A672P			Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM-type 1	672						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(8)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATCATCAAAGGCTATCTTAAT	0.368000													6	25					0	0	1	0	0
ADH4	127	broad.mit.edu	37	4	100047875	100047875	+	Frame_Shift_Del	DEL	T	T	-			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr4:100047875delT	ENST00000508393.1	-	9	1210	c.1045delA	c.(1045-1047)gtfs	p.S349fs	ADH4_ENST00000505590.1_Frame_Shift_Del_p.S349fs|ADH4_ENST00000423445.1_Frame_Shift_Del_p.S349fs|ADH4_ENST00000265512.7_Frame_Shift_Del_p.S330fs|RP11-696N14.1_ENST00000500358.2_RNA			P08319	ADH4_HUMAN	alcohol dehydrogenase 4 (class II), pi polypeptide	330					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)|skin(2)	18				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	GAATCTACACTTTTCCAACCT	0.373													22	52	---	---	---	---					
ARHGEF17	9828	broad.mit.edu	37	11	73074835	73074835	+	Frame_Shift_Del	DEL	A	A	-			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr11:73074835delA	ENST00000263674.3	+	16	5640	c.5290delA	c.(5290-5292)acfs	p.N1764fs		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1764					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						TGACCGCAGGAACAGCATGAA	0.602													17	30	---	---	---	---					
CCDC144B	284047	broad.mit.edu	37	17	18498498	18498498	+	RNA	DEL	A	A	-	rs80104188		TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chr17:18498498delA	ENST00000442583.1	-	0	749																				NS(3)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(6)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	36						TGCAGGCCTGAAAAAAAAAAA	0.244													3	3	---	---	---	---					
KDM6A	7403	broad.mit.edu	37	X	44732958	44732958	+	Splice_Site	DEL	G	G	-			TCGA-RW-A684-01A-12D-A35D-08	TCGA-RW-A684-10A-01D-A35B-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	294d435e-dba0-4226-982b-48fc102ccf14	44eaf2f9-5b8b-48bc-b806-92df51bef7ef	g.chrX:44732958delG	ENST00000377967.4	+	1	202	c.161_splice	c.e1+1	p.S54_splice	KDM6A_ENST00000536777.1_Splice_Site_p.S54_splice|KDM6A_ENST00000543216.1_Splice_Site_p.S54_splice|KDM6A_ENST00000382899.4_Splice_Site_p.S54_splice	NM_021140.2	NP_066963.2	O15550	KDM6A_HUMAN	lysine (K)-specific demethylase 6A	54					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.0(8)|p.0?(6)		NS(1)|breast(7)|central_nervous_system(27)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(24)|kidney(24)|large_intestine(9)|liver(1)|lung(21)|oesophagus(11)|pancreas(2)|prostate(5)|skin(1)|soft_tissue(1)|urinary_tract(29)	170						GGACTGGACAGGTACGGGCCG	0.731			"""D, N, F, S"""		"""renal, oesophageal SCC, MM"""								2	4	---	---	---	---