Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KCNH5	27133	broad.mit.edu	37	14	63511901	63511901	+	Missense_Mutation	SNP	G	G	A			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr14:63511901G>A	ENST00000322893.7	-	1	272	c.4C>T	c.(4-6)Ccg>Tcg	p.P2S	KCNH5_ENST00000394964.2_Intron|KCNH5_ENST00000420622.2_Missense_Mutation_p.P2S|KCNH5_ENST00000394968.1_Intron	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	2					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTGCCCCCCGGCATCCTGGGT	0.602000													3	42					0	0	1	0	0
IQSEC3	440073	broad.mit.edu	37	12	247904	247904	+	Missense_Mutation	SNP	G	G	A			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr12:247904G>A	ENST00000538872.1	+	4	1493	c.1375G>A	c.(1375-1377)Gcg>Acg	p.A459T	IQSEC3_ENST00000382841.2_Missense_Mutation_p.A156T|RP11-598F7.4_ENST00000505893.2_RNA|IQSEC3_ENST00000326261.4_Missense_Mutation_p.A459T			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	459					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		gccggagagcgcgggccccgg	0.776000													3	5					0	0	1	0	0
IL2RB	3560	broad.mit.edu	37	22	37538550	37538550	+	Missense_Mutation	SNP	C	C	T			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr22:37538550C>T	ENST00000216223.5	-	4	404	c.206G>A	c.(205-207)cGg>cAg	p.R69Q		NM_000878.3	NP_000869.1	P14784	IL2RB_HUMAN	interleukin 2 receptor, beta	69					interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(5)	23					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	TTGGTTCCACCGCCTTTCATG	0.577000													6	54					0	0	1	0	0
VNN2	8875	broad.mit.edu	37	6	133073759	133073759	+	Missense_Mutation	SNP	G	G	T			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr6:133073759G>T	ENST00000326499.6	-	4	791	c.667C>A	c.(667-669)Ctg>Atg	p.L223M	VNN2_ENST00000525270.1_Missense_Mutation_p.L170M|VNN2_ENST00000525289.1_Intron	NM_004665.2	NP_004656.2	O95498	VNN2_HUMAN	vanin 2	223	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		TCTTTCACCAGGGTAACACCA	0.443000													4	69					0.00909568	0.00970206	1	1	0
TUBB8P7	197331	broad.mit.edu	37	16	90162620	90162620	+	RNA	SNP	T	T	G			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr16:90162620T>G	ENST00000564451.1	+	0	1973																											CTAGGTAAAGTGGGGAAGCAG	0.483000													4	167					0	0	1	0	0
IGKV3-20	28912	broad.mit.edu	37	2	89442552	89442552	+	RNA	SNP	A	A	G			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr2:89442552A>G	ENST00000492167.1	-	0	91																											CCTGGGAGCCAGAGTAGCAGG	0.507000													40	41					0	0	1	0	0
LINC01420	550643	broad.mit.edu	37	X	56763812	56763812	+	RNA	SNP	A	A	G			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chrX:56763812A>G	ENST00000374922.4	+	0	468					NR_015367.2																						GTCAGGTCCAATGCACTCTTA	0.393000													22	19					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114680328	114680328	+	Missense_Mutation	SNP	C	C	T			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr1:114680328C>T	ENST00000393296.1	-	3	937	c.860G>A	c.(859-861)cGc>cAc	p.R287H	SYT6_ENST00000369547.1_Missense_Mutation_p.R202H			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	287	C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGGGTCTTGCGGTGCACCCG	0.547000													5	26					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14852025	14852025	+	Missense_Mutation	SNP	G	G	T			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr18:14852025G>T	ENST00000358984.4	+	36	3905	c.3725G>T	c.(3724-3726)aGc>aTc	p.S1242I		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1327										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						AAATCCAAAAGCCCAAAAATT	0.363000													7	6					0.27861	0.27861	1	1	0
IL34	146433	broad.mit.edu	37	16	70688489	70688489	+	Missense_Mutation	SNP	T	T	C			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr16:70688489T>C	ENST00000429149.2	+	3	632	c.77T>C	c.(76-78)aTg>aCg	p.M26T	IL34_ENST00000288098.2_Missense_Mutation_p.M26T|IL34_ENST00000566361.1_Start_Codon_SNP_p.M1T|IL34_ENST00000569641.1_Intron	NM_001172771.1|NM_152456.2	NP_001166242.1|NP_689669.2	Q6ZMJ4	IL34_HUMAN	interleukin 34	26					positive regulation of cell proliferation|positive regulation of protein phosphorylation	extracellular space	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding			breast(1)|central_nervous_system(1)|kidney(9)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(2)	17						CCTTTGGAGATGTGGCCCTTG	0.567000											OREG0023916	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	30					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32633094	32633094	+	Silent	SNP	A	A	T			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr9:32633094A>T	ENST00000242310.4	-	1	2573	c.2484T>A	c.(2482-2484)gtT>gtA	p.V828V		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	828					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GGTAAATAAAAACCTGTAGAA	0.438000													47	57					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154842200	154842202	+	In_Frame_Del	DEL	GCT	GCT	-	rs58327065		TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr1:154842200_154842202delGCT	ENST00000271915.3	-	1	554_556	c.239_241delAGC	c.(238-243)cca>c	p.QP80del		NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	80	Poly-Gln.					integral to membrane	calmodulin binding	p.Q80_P81insQQ(2)		cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			GGATGCGGTGgctgctgctgctg	0.700													3	3	---	---	---	---					
PDE2A	5138	broad.mit.edu	37	11	72292484	72292484	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr11:72292484delG	ENST00000334456.5	-	23	2207	c.1962delC	c.(1960-1962)ccfs	p.P654fs	PDE2A_ENST00000444035.2_Frame_Shift_Del_p.P645fs|PDE2A_ENST00000418754.2_Frame_Shift_Del_p.P539fs|PDE2A_ENST00000376450.3_Frame_Shift_Del_p.P398fs|PDE2A_ENST00000540345.1_Frame_Shift_Del_p.P645fs|PDE2A_ENST00000544570.1_Frame_Shift_Del_p.P647fs	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	654	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	AGTTGTGGTAGGGGGGATCCC	0.582													2	4	---	---	---	---					
DLAT	1737	broad.mit.edu	37	11	111930686	111930690	+	Frame_Shift_Del	DEL	TTGTG	TTGTG	-			TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr11:111930686_111930690delTTGTG	ENST00000280346.6	+	12	2233_2237	c.1574_1578delTTGTG	c.(1573-1578)afs	p.IV525fs	DLAT_ENST00000537636.1_Frame_Shift_Del_p.IV296fs|DLAT_ENST00000393051.1_Frame_Shift_Del_p.IV420fs	NM_001931.4	NP_001922.2	P10515	ODP2_HUMAN	dihydrolipoamide S-acetyltransferase	525	Catalytic (By similarity).				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)	22		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	ATCACACCTATTGTGTTTAATGCAC	0.351													8	21	---	---	---	---					
SREBF1	6720	broad.mit.edu	37	17	17718150	17718152	+	Splice_Site	DEL	GGT	GGT	-	rs143021204		TCGA-TT-A6YJ-01A-11D-A35I-08	TCGA-TT-A6YJ-10B-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fa692ea3-6a32-4874-9a85-1d116dbdbb67	14d15ddc-360d-4895-ba5a-fdeec5ee713f	g.chr17:17718150_17718152delGGT	ENST00000355815.4	-	15	2858_2860	c.2692_splice	c.e15+1	p.T897_splice	SREBF1_ENST00000395757.1_Splice_Site_p.T613_splice|SREBF1_ENST00000338854.5_Splice_Site_p.T867_splice|SREBF1_ENST00000261646.5_Splice_Site_p.T867_splice	NM_001005291.2	NP_001005291.1	P36956	SRBP1_HUMAN	sterol regulatory element binding transcription factor 1	867					cellular response to starvation|cholesterol metabolic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter	endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleus	protein binding|sequence-specific DNA binding transcription factor activity|sterol response element binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	14						GGGACTCACCGGTGGTGGTGGCC	0.655													2	4	---	---	---	---