Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BRWD3	254065	broad.mit.edu	37	X	79999587	79999587	+	Missense_Mutation	SNP	T	T	C			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chrX:79999587T>C	ENST00000373275.4	-	8	973	c.757A>G	c.(757-759)Act>Gct	p.T253A		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	253										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						GGTGCACAAGTTCGAAGACAC	0.403000													15	9					0	0	1	0	0
RWDD4	201965	broad.mit.edu	37	4	184572391	184572391	+	Silent	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr4:184572391G>A	ENST00000326397.5	-	3	467	c.195C>T	c.(193-195)aaC>aaT	p.N65N	RWDD4_ENST00000512740.1_Silent_p.N2N|RWDD4_ENST00000327570.9_Silent_p.N65N|RWDD4_ENST00000510968.1_Intron	NM_152682.2	NP_689895.2	Q6NW29	RWDD4_HUMAN	RWD domain containing 4	65	RWD.									large_intestine(2)|lung(4)|ovary(1)|prostate(1)	8						TAAAAAAAGCGTTCATAGATA	0.368000													36	49					0	0	1	0	0
RET	5979	broad.mit.edu	37	10	43609939	43609939	+	Missense_Mutation	SNP	G	G	T			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr10:43609939G>T	ENST00000355710.3	+	11	2123	c.1891G>T	c.(1891-1893)Gac>Tac	p.D631Y	RET_ENST00000340058.5_Missense_Mutation_p.D631Y	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	631			D -> G (in thyroid carcinoma; somatic mutation).		homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity	p.L629_D631>H(2)|p.D627_L633>E(1)	CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	TCCACTGTGCGACGAGCTGTG	0.622000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				17	24					2.37509e-13	2.42787e-13	1	1	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													3	65					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167794084	167794084	+	Missense_Mutation	SNP	C	C	T	rs139094168		TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr1:167794084C>T	ENST00000367848.1	-	27	3981	c.3484G>A	c.(3484-3486)Gct>Act	p.A1162T	ADCY10_ENST00000485964.1_5'UTR|ADCY10_ENST00000367851.4_Missense_Mutation_p.A1254T|ADCY10_ENST00000545172.1_Missense_Mutation_p.A1101T			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1254					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TCTAGGTAAGCCTTAATGATC	0.463000													25	52					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55527178	55527178	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr16:55527178G>A	ENST00000219070.4	+	9	1954	c.1445G>A	c.(1444-1446)cGt>cAt	p.R482H	MMP2_ENST00000570308.1_Missense_Mutation_p.R406H|MMP2_ENST00000543485.1_Missense_Mutation_p.R406H|MMP2_ENST00000437642.2_Missense_Mutation_p.R432H	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	482	Hemopexin-like 1.|Required for inhibitor TIMP2 binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	GCTCAGATCCGTGGTGAGATC	0.532000													48	105					0	0	1	0	0
CARD18	59082	broad.mit.edu	37	11	105009793	105009793	+	Missense_Mutation	SNP	C	C	T			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr11:105009793C>T	ENST00000530950.1	-	2	19	c.20G>A	c.(19-21)cGt>cAt	p.R7H	CARD18_ENST00000532895.1_5'UTR|CARD18_ENST00000526823.1_5'UTR	NM_021571.3	NP_067546.1	P57730	CAR18_HUMAN	caspase recruitment domain family, member 18	7	CARD.				inflammatory response|regulation of apoptosis	intracellular	cysteine-type endopeptidase inhibitor activity			central_nervous_system(1)|ovary(1)	2						TCTCTTTTTACGCAAGAGTTG	0.378000													6	55					0	0	1	0	0
WNT3	7473	broad.mit.edu	37	17	44847186	44847186	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr17:44847186G>A	ENST00000225512.5	-	3	713	c.551C>T	c.(550-552)tCg>tTg	p.S184L		NM_030753.4	NP_110380.1	P56703	WNT3_HUMAN	wingless-type MMTV integration site family, member 3	184					canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|cellular response to retinoic acid|dorsal/ventral axis specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic pattern specification|head morphogenesis|hemopoietic stem cell proliferation|inner ear morphogenesis|limb bud formation|mammary gland epithelium development|mesoderm formation|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|positive regulation of cell proliferation|Spemann organizer formation at the anterior end of the primitive streak|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane fraction|membrane raft|plasma membrane|proteinaceous extracellular matrix	frizzled binding|frizzled-2 binding|signal transducer activity			endometrium(2)|large_intestine(6)|lung(4)|prostate(1)	13			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GTTCATGGCCGAGCGCGCGTC	0.687000													3	43					0	0	1	0	0
CASP2	835	broad.mit.edu	37	7	142985577	142985577	+	Missense_Mutation	SNP	C	C	T			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr7:142985577C>T	ENST00000310447.5	+	1	270	c.29C>T	c.(28-30)tCc>tTc	p.S10F	CASP2_ENST00000392925.2_Missense_Mutation_p.S10F	NM_032982.3|NM_032983.3	NP_116764.2|NP_116765.2	P42575	CASP2_HUMAN	caspase 2, apoptosis-related cysteine peptidase	10					apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|protein maturation by peptide bond cleavage	cytosol	cysteine-type endopeptidase activity|enzyme binding|protein binding|protein domain specific binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)	21	Melanoma(164;0.059)					GGGTCTTGGTCCACCTTCCAG	0.677000													12	20					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628278	29628278	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr20:29628278G>A	ENST00000278882.3	+	6	660	c.280G>A	c.(280-282)Gca>Aca	p.A94T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A94T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A99T																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGCAATGAAGCAGGGGACAT	0.373000													4	112					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													4	84					0	0	1	0	0
MCOLN2	255231	broad.mit.edu	37	1	85431293	85431293	+	Missense_Mutation	SNP	C	C	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr1:85431293C>A	ENST00000370608.3	-	2	243	c.176G>T	c.(175-177)aGa>aTa	p.R59I	MCOLN2_ENST00000531325.1_5'UTR|MCOLN2_ENST00000284027.5_Missense_Mutation_p.R31I	NM_153259.2	NP_694991.2	Q8IZK6	MCLN2_HUMAN	mucolipin 2	59						integral to membrane	ion channel activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	18				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		AATCTGGCGTCTGGCTCGGTA	0.413000													3	29					0.115264	0.115264	1	1	0
MSLN	10232	broad.mit.edu	37	16	816649	816649	+	Silent	SNP	T	T	G			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr16:816649T>G	ENST00000382862.3	+	13	1331	c.1236T>G	c.(1234-1236)ccT>ccG	p.P412P	MSLN_ENST00000563941.1_Intron|MSLN_ENST00000545450.2_Intron|MSLN_ENST00000566549.1_Intron	NM_013404.4	NP_037536.2	Q13421	MSLN_HUMAN	mesothelin	412					cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				breast(2)|kidney(2)|lung(11)|pancreas(1)|prostate(1)|skin(3)	20		Hepatocellular(780;0.00335)				ACAAGGCTCCTCGGCGGCCCC	0.637000													17	115					0	0	1	0	0
TBC1D10C	374403	broad.mit.edu	37	11	67177213	67177213	+	Missense_Mutation	SNP	C	C	G			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr11:67177213C>G	ENST00000312390.5	+	10	1358	c.1329C>G	c.(1327-1329)gaC>gaG	p.D443E	TBC1D10C_ENST00000526387.1_3'UTR|TBC1D10C_ENST00000542590.1_Missense_Mutation_p.D443E	NM_198517.3	NP_940919.1	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	443	Interaction with calcineurin.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCTTCCTGGACACCCGCTTCT	0.647000													5	17					0	0	1	0	0
TNKS	8658	broad.mit.edu	37	8	9627729	9627729	+	Missense_Mutation	SNP	A	A	G			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr8:9627729A>G	ENST00000310430.6	+	26	3880	c.3854A>G	c.(3853-3855)aAt>aGt	p.N1285S	TNKS_ENST00000518281.1_Missense_Mutation_p.N1048S	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	1285	PARP catalytic.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		CCGAGCGTCAATGGGCTGGCA	0.473000													16	33					0	0	1	0	0
FBXO15	201456	broad.mit.edu	37	18	71740825	71740825	+	Silent	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr18:71740825G>A	ENST00000269500.5	-	10	1511	c.1176C>T	c.(1174-1176)taC>taT	p.Y392Y	FBXO15_ENST00000580806.1_5'UTR|FBXO15_ENST00000419743.2_Silent_p.Y468Y	NM_152676.2	NP_689889.1	Q8NCQ5	FBX15_HUMAN	F-box protein 15	392										autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	27		Esophageal squamous(42;0.103)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.143)		CCGCATCAACGTAGTCCACGT	0.502000													5	183					0	0	1	0	0
WHAMMP3	339005	broad.mit.edu	37	15	23205094	23205094	+	RNA	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr15:23205094G>A	ENST00000400153.2	-	0	760					NR_003521.1																						AGTACTGGAAGAACGTGGTTG	0.373000													3	20					0	0	1	0	0
PLXNB1	5364	broad.mit.edu	37	3	48445926	48445926	+	Silent	SNP	T	T	C			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr3:48445926T>C	ENST00000358536.4	-	38	6644	c.6375A>G	c.(6373-6375)gcA>gcG	p.A2125A	PLXNB1_ENST00000358459.4_Silent_p.A1942A|PLXNB1_ENST00000448774.2_Silent_p.A736A|PLXNB1_ENST00000456774.1_Silent_p.A1942A|PLXNB1_ENST00000296440.6_Silent_p.A2125A	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	2125					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCACAGCAGCTGCAATCTGCT	0.587000													3	23					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803543	142803543	+	RNA	SNP	C	C	T			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr1:142803543C>T	ENST00000423385.1	-	0	1422																											TGTTGGAATTCCTGATGAATC	0.269000													4	157					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29628299	29628299	+	Missense_Mutation	SNP	A	A	G			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr20:29628299A>G	ENST00000278882.3	+	6	681	c.301A>G	c.(301-303)Agt>Ggt	p.S101G	FRG1B_ENST00000358464.4_Missense_Mutation_p.S101G|FRG1B_ENST00000439954.2_Missense_Mutation_p.S106G																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AGAAGCAAAAAGTAAAACAGC	0.363000													5	89					0	0	1	0	0
GJA5	2702	broad.mit.edu	37	1	147230307	147230307	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr1:147230307G>A	ENST00000271348.2	-	2	1201	c.1040C>T	c.(1039-1041)gCc>gTc	p.A347V	GJA5_ENST00000369237.1_Missense_Mutation_p.A347V|RP11-433J22.2_ENST00000428911.1_RNA	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	347					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CTTGCTGCTGGCCTTACTAAG	0.542000													5	70					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156482298	156482298	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr5:156482298G>A	ENST00000339252.3	-	2	825	c.293C>T	c.(292-294)tCt>tTt	p.S98F	HAVCR1_ENST00000544197.1_Missense_Mutation_p.S98F|HAVCR1_ENST00000523175.1_Missense_Mutation_p.S98F|HAVCR1_ENST00000425854.1_Missense_Mutation_p.S98F|HAVCR1_ENST00000522693.1_Missense_Mutation_p.S98F	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	98	Ig-like V-type.				interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCCACTGTCAGACACAGCTGT	0.453000													8	83					0	0	1	0	0
CCL13	6357	broad.mit.edu	37	17	32685095	32685095	+	Missense_Mutation	SNP	G	G	C			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr17:32685095G>C	ENST00000225844.2	+	3	317	c.242G>C	c.(241-243)tGg>tCg	p.W81S		NM_005408.2	NP_005399.1	Q99616	CCL13_HUMAN	chemokine (C-C motif) ligand 13	81					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response	extracellular space	chemokine activity|signal transducer activity			large_intestine(1)|prostate(1)	2		Ovarian(249;0.0443)|Breast(31;0.151)				AAGGAGAAGTGGGTCCAGAAT	0.493000													16	22					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38051409	38051409	+	Silent	SNP	C	C	T			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr4:38051409C>T	ENST00000261439.4	+	11	2155	c.1800C>T	c.(1798-1800)ttC>ttT	p.F600F	TBC1D1_ENST00000508802.1_Silent_p.F600F	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	600						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						TGAGTCACTTCCCCATCGAAT	0.602000													32	60					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130415	45130415	+	Silent	SNP	T	T	C			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr20:45130415T>C	ENST00000457685.2	-	6	2772	c.1449A>G	c.(1447-1449)gaA>gaG	p.E483E	ZNF334_ENST00000347606.4_Silent_p.E521E|ZNF334_ENST00000593880.1_Silent_p.E544E			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				CATGCCCATGTTCACTACACT	0.403000													5	230					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45518255	45518255	+	Silent	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr21:45518255G>A	ENST00000291574.4	+	21	3361	c.3186G>A	c.(3184-3186)aaG>aaA	p.K1062K		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1062					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						ACAACGTGAAGGCTGAGATCT	0.502000													11	79					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33413856	33413856	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr2:33413856G>A	ENST00000404816.2	+	7	1992	c.1639G>A	c.(1639-1641)Gtc>Atc	p.V547I	LTBP1_ENST00000354476.3_Missense_Mutation_p.V547I|LTBP1_ENST00000390003.4_Missense_Mutation_p.V221I|LTBP1_ENST00000418533.2_Missense_Mutation_p.V221I|LTBP1_ENST00000404525.1_Missense_Mutation_p.V221I|LTBP1_ENST00000407925.1_Missense_Mutation_p.V221I|LTBP1_ENST00000402934.1_Missense_Mutation_p.V221I			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	547					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CATTCCTCACGTCTACCCCGT	0.537000													36	61					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													5	66					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65074569	65074569	+	Silent	SNP	C	C	T			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr17:65074569C>T	ENST00000358691.5	-	33	5794	c.5628G>A	c.(5626-5628)gcG>gcA	p.A1876A	HELZ_ENST00000580168.1_Silent_p.A1877A	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TGGCCGACTCCGCGATCTGCT	0.612000													84	129					0	0	1	0	0
ARL2	402	broad.mit.edu	37	11	64781694	64781694	+	Silent	SNP	C	C	T			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr11:64781694C>T	ENST00000246747.4	+	1	110	c.15C>T	c.(13-15)acC>acT	p.T5T	ARL2_ENST00000529384.1_Silent_p.T5T|ARL2_ENST00000533729.1_Silent_p.T5T|SNX15_ENST00000301886.3_3'UTR	NM_001667.3	NP_001658.2	P36404	ARL2_HUMAN	ADP-ribosylation factor-like 2	5					cell cycle|centrosome organization|maintenance of protein location in nucleus|negative regulation of GTPase activity|positive regulation of cell-substrate adhesion|positive regulation of microtubule polymerization|small GTPase mediated signal transduction|tight junction assembly|tubulin complex assembly	centrosome|lateral plasma membrane|mitochondrial intermembrane space|nucleus	GTP binding|GTPase activity|GTPase inhibitor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	5						GGCTCCTGACCATTCTGAAGA	0.672000													8	8					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276366	186276366	+	Silent	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr1:186276366G>A	ENST00000445192.2	+	7	1560	c.1515G>A	c.(1513-1515)gaG>gaA	p.E505E	PRG4_ENST00000367483.4_Silent_p.E464E|PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367485.4_Silent_p.E412E|PRG4_ENST00000367486.3_Silent_p.E462E	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	505	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CTCCCAAGGAGCCTGCACCCA	0.647000													4	128					0	0	1	0	0
TAB3	257397	broad.mit.edu	37	X	30872733	30872733	+	Missense_Mutation	SNP	T	T	C			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chrX:30872733T>C	ENST00000378933.1	-	3	1226	c.1049A>G	c.(1048-1050)tAt>tGt	p.Y350C	TAB3_ENST00000378930.3_Missense_Mutation_p.Y350C|TAB3_ENST00000378932.2_Missense_Mutation_p.Y350C|TAB3-AS2_ENST00000445240.1_RNA|TAB3_ENST00000288422.2_Missense_Mutation_p.Y350C	NM_152787.3	NP_690000.2	Q8N5C8	TAB3_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 3	350	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|skin(1)	27						GTATGGAAGATAGGCTACTGA	0.433000													3	58					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	T	C			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr22:18844763T>C	ENST00000412938.1	+	0	3013																											TCACAGCCTCTGAGGGCAGCA	0.562000													3	13					0	0	1	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102551717	102551717	+	Missense_Mutation	SNP	T	T	G			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr14:102551717T>G	ENST00000334701.7	-	5	1228	c.947A>C	c.(946-948)cAa>cCa	p.Q316P	HSP90AA1_ENST00000441629.2_Missense_Mutation_p.Q15P|HSP90AA1_ENST00000216281.8_Missense_Mutation_p.Q194P	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	194					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	GTACTCAGTTTGGTCTTCTTT	0.343000													21	32					0	0	1	0	0
SYT3	84258	broad.mit.edu	37	19	51135613	51135613	+	Missense_Mutation	SNP	G	G	A			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr19:51135613G>A	ENST00000338916.4	-	2	1237	c.604C>T	c.(604-606)Ccc>Tcc	p.P202S	SYT3_ENST00000600079.1_Missense_Mutation_p.P202S|SYT3_ENST00000593901.1_Missense_Mutation_p.P202S|SYT3_ENST00000544769.1_Missense_Mutation_p.P202S	NM_032298.2	NP_115674.1	Q9BQG1	SYT3_HUMAN	synaptotagmin III	202						cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|prostate(2)|skin(3)|urinary_tract(2)	35		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		CCACTGGGGGGCAGCAGGAGC	0.652000													18	31					0	0	1	0	0
GPR148	344561	broad.mit.edu	37	2	131486787	131486787	+	Silent	SNP	C	C	T			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr2:131486787C>T	ENST00000309926.4	+	1	145	c.63C>T	c.(61-63)ctC>ctT	p.L21L		NM_207364.2	NP_997247.2	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	21						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(15)|skin(3)|upper_aerodigestive_tract(1)	27	Colorectal(110;0.1)					TGATCCAGCTCATCAGCAAGA	0.612000													14	98					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39885298	39885298	+	Silent	SNP	C	C	T	rs139289744	byFrequency	TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr15:39885298C>T	ENST00000260356.5	+	18	3030	c.2865C>T	c.(2863-2865)acC>acT	p.T955T		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	955					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TCAGTGAGACCGATTTCCGCC	0.502000													5	36					0	0	1	0	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89083945	89083946	+	RNA	INS	-	-	GC			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr2:89083945_89083946insGC	ENST00000393525.3	+	0	576																											GTATTCCTTTTTTTTCAGTGTA	0.347													3	4	---	---	---	---					
CTC-338M12.9	0	broad.mit.edu	37	5	180708776	180708777	+	RNA	INS	-	-	G	rs140221514		TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr5:180708776_180708777insG	ENST00000412295.2	+	0	238																											gggcggtaggagggggctggag	0.728													6	10	---	---	---	---					
EFNB3	1949	broad.mit.edu	37	17	7612004	7612004	+	Frame_Shift_Del	DEL	A	A	-			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chr17:7612004delA	ENST00000226091.2	+	4	957	c.560delA	c.(559-561)gafs	p.E187fs		NM_001406.3	NP_001397.1	Q15768	EFNB3_HUMAN	ephrin-B3	187					cell-cell signaling|interspecies interaction between organisms	integral to plasma membrane	ephrin receptor binding|transmembrane-ephrin receptor activity			large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	8		all_cancers(10;1.14e-06)|Prostate(122;0.081)				ATGCCCATGGAAAGAGACCGA	0.632													2	4	---	---	---	---					
KLHL34	257240	broad.mit.edu	37	X	21674920	21674922	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-W2-A7HA-01B-11D-A35I-08	TCGA-W2-A7HA-10C-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	128bdc90-ed54-4b8e-bfcb-b8577370c799	89e66736-c853-4d3c-b607-ac112afd81a6	g.chrX:21674920_21674922delCTC	ENST00000379499.2	-	1	1526_1528	c.985_987delGAG	c.(985-987)del	p.E329del		NM_153270.1	NP_695002.1	Q8N239	KLH34_HUMAN	kelch-like family member 34	329	Glu-rich.									cervix(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	26						TGAGCTCCCActcctcctcctcc	0.650													2	4	---	---	---	---