Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
YBX2	51087	broad.mit.edu	37	17	7193313	7193313	+	Silent	SNP	C	C	T			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr17:7193313C>T	ENST00000007699.5	-	6	885	c.822G>A	c.(820-822)ccG>ccA	p.P274P		NM_015982.3	NP_057066.2	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	274	Pro-rich.|Required for mRNA-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|skin(3)	12						GGAATCTGGGCGGGGGGACTC	0.627000													4	18					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													4	51					0	0	1	0	0
FANK1	92565	broad.mit.edu	37	10	127693555	127693555	+	Silent	SNP	G	G	A	rs137911829		TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr10:127693555G>A	ENST00000368695.1	+	7	746	c.624G>A	c.(622-624)ctG>ctA	p.L208L	FANK1_ENST00000368693.1_Silent_p.L214L|FANK1_ENST00000477963.1_3'UTR	NM_145235.3	NP_660278.3	Q8TC84	FANK1_HUMAN	fibronectin type III and ankyrin repeat domains 1	214						cytoplasm|nucleus				central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(10)|ovary(1)|urinary_tract(1)	21		all_lung(145;0.00752)|Lung NSC(174;0.0115)|Colorectal(57;0.0847)|all_neural(114;0.0936)				GTACAGCTCTGCACTGGGCTG	0.532000													5	76					0	0	1	0	0
CACNB2	783	broad.mit.edu	37	10	18828544	18828544	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr10:18828544G>A	ENST00000396576.2	+	13	2210	c.1709G>A	c.(1708-1710)cGc>cAc	p.R570H	RP11-499P20.2_ENST00000425669.1_RNA|CACNB2_ENST00000377315.4_Missense_Mutation_p.R577H|CACNB2_ENST00000324631.7_Missense_Mutation_p.R625H|CACNB2_ENST00000352115.6_Missense_Mutation_p.R601H|CACNB2_ENST00000377319.3_Missense_Mutation_p.R532H|CACNB2_ENST00000282343.8_Missense_Mutation_p.R597H|CACNB2_ENST00000377329.4_Missense_Mutation_p.R571H|CACNB2_ENST00000377328.1_Missense_Mutation_p.R375H|CACNB2_ENST00000377331.2_Missense_Mutation_p.R573H	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	625					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	AACAAGCAGCGCAGCCGTCAT	0.547000													11	46					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3327970	3327970	+	Silent	SNP	C	C	T			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr1:3327970C>T	ENST00000378398.3	+	10	1294	c.1212C>T	c.(1210-1212)taC>taT	p.Y404Y	PRDM16_ENST00000442529.2_Silent_p.Y403Y|PRDM16_ENST00000441472.2_Silent_p.Y403Y|PRDM16_ENST00000511072.1_Silent_p.Y404Y|PRDM16_ENST00000270722.5_Silent_p.Y403Y|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000378391.2_Silent_p.Y403Y|PRDM16_ENST00000514189.1_Silent_p.Y404Y			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	403					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		ACAAGTCCTACACGCAGTTCT	0.542000			T	EVI1	"""MDS, AML"""								6	8					0	0	1	0	0
IQCE	23288	broad.mit.edu	37	7	2644558	2644558	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr7:2644558G>A	ENST00000402050.2	+	19	1860	c.1676G>A	c.(1675-1677)cGg>cAg	p.R559Q	IQCE_ENST00000325979.7_Missense_Mutation_p.R494Q|IQCE_ENST00000438376.2_Missense_Mutation_p.R543Q|IQCE_ENST00000404984.1_Missense_Mutation_p.R508Q	NM_001100390.1|NM_152558.3	NP_001093860.1|NP_689771.3	Q6IPM2	IQCE_HUMAN	IQ motif containing E	559	IQ 1.									breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.23e-13)		CATCTCACGCGGACAAAGCTC	0.622000													6	10					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91711856	91711856	+	Silent	SNP	T	T	C			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr7:91711856T>C	ENST00000359028.2	+	33	8301	c.8076T>C	c.(8074-8076)caT>caC	p.H2692H	AKAP9_ENST00000358100.2_Silent_p.H2692H|AKAP9_ENST00000356239.3_Silent_p.H2680H			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2692	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGCTATTTCATAGCAATGAAG	0.338000			T	BRAF	papillary thyroid								35	63					0	0	1	0	0
CCSER1	401145	broad.mit.edu	37	4	91229914	91229914	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr4:91229914A>G	ENST00000509176.1	+	2	767	c.479A>G	c.(478-480)gAt>gGt	p.D160G	CCSER1_ENST00000333691.8_Missense_Mutation_p.D160G|CCSER1_ENST00000432775.2_Missense_Mutation_p.D160G	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		AGTGAAGGGGATGATTCTGGT	0.358000													12	20					0	0	1	0	0
FGFR4	2264	broad.mit.edu	37	5	176523689	176523689	+	Silent	SNP	G	G	A			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr5:176523689G>A	ENST00000292408.4	+	16	2345	c.2100G>A	c.(2098-2100)tcG>tcA	p.S700S	FGFR4_ENST00000393648.2_Silent_p.S632S|FGFR4_ENST00000393637.1_Silent_p.S660S|FGFR4_ENST00000502906.1_Silent_p.S700S|FGFR4_ENST00000292410.3_Silent_p.S660S	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	700	Protein kinase.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	AGCTGTTCTCGCTGCTGCGGG	0.652000										TSP Lung(9;0.080)			11	46					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63246574	63246574	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr14:63246574G>A	ENST00000322893.7	-	10	2159	c.1891C>T	c.(1891-1893)Cgg>Tgg	p.R631W	KCNH5_ENST00000420622.2_Intron|KCNH5_ENST00000394968.1_Missense_Mutation_p.R573W	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	631					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GTCAGTGCCCGGACGTTCGCA	0.453000													3	49					0	0	1	0	0
F12	2161	broad.mit.edu	37	5	176833050	176833050	+	Missense_Mutation	SNP	G	G	T			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr5:176833050G>T	ENST00000253496.3	-	3	176	c.128C>A	c.(127-129)aCc>aAc	p.T43N		NM_000505.3	NP_000496.2	P00748	FA12_HUMAN	coagulation factor XII (Hageman factor)	43	Fibronectin type-II.				Factor XII activation|fibrinolysis|innate immune response|positive regulation of blood coagulation|positive regulation of fibrinolysis|positive regulation of plasminogen activation|protein autoprocessing|response to misfolded protein|zymogen activation	extracellular space|plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	12	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGCTCCCCGGTGACAGTGAG	0.592000									Hereditary Angioedema				18	35					5.35267e-07	6.04333e-07	1	1	0
KRTAP9-9	81870	broad.mit.edu	37	17	39411940	39411940	+	Silent	SNP	C	C	T			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr17:39411940C>T	ENST00000394008.1	+	1	305	c.303C>T	c.(301-303)ggC>ggT	p.G101G		NM_030975.2	NP_112237.2	B5MDD6	B5MDD6_HUMAN	keratin associated protein 9-9	101						keratin filament				endometrium(3)|skin(2)|upper_aerodigestive_tract(1)	6		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CCAGCTGTGGCCAGAGCAGCT	0.617000													4	127					0	0	1	0	0
ZHX2	22882	broad.mit.edu	37	8	123965941	123965941	+	Missense_Mutation	SNP	T	T	G			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr8:123965941T>G	ENST00000314393.4	+	3	3026	c.2191T>G	c.(2191-2193)Tac>Gac	p.Y731D		NM_014943.3	NP_055758.1	Q9Y6X8	ZHX2_HUMAN	zinc fingers and homeoboxes 2	731						cytoplasm|nucleus|plasma membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(4)|stomach(3)|urinary_tract(1)	45	Lung NSC(37;2e-09)|Ovarian(258;0.0205)|Hepatocellular(40;0.105)		STAD - Stomach adenocarcinoma(47;0.00527)			TCCACAATATTACAAGGACCC	0.527000													13	69					0	0	1	0	0
FRG1BP	284802	broad.mit.edu	37	20	29625955	29625955	+	Nonsense_Mutation	SNP	A	A	T			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr20:29625955A>T	ENST00000278882.3	+	5	579	c.199A>T	c.(199-201)Aga>Tga	p.R67*	FRG1B_ENST00000439954.2_Nonsense_Mutation_p.R72*|FRG1B_ENST00000358464.4_Nonsense_Mutation_p.R67*																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATTGGACCAAGAGAACAATG	0.338000													7	96					0	0	1	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													4	63					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687983	68687983	+	Missense_Mutation	SNP	G	G	C			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr10:68687983G>C	ENST00000361320.4	+	2	1887	c.1309G>C	c.(1309-1311)Gtt>Ctt	p.V437L	CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	437						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						CATCCTGCTGGTTATCTACGT	0.567000													5	61					0	0	1	0	0
ZNF491	126069	broad.mit.edu	37	19	11917376	11917376	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr19:11917376G>A	ENST00000323169.5	+	3	939	c.608G>A	c.(607-609)cGc>cAc	p.R203H	ZNF491_ENST00000492230.1_Intron	NM_152356.3	NP_689569.2	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(14)|lung(6)|ovary(2)|skin(1)	26						AGTTCCTTTCGCAGACATGAA	0.438000													13	29					0	0	1	0	0
USP15	9958	broad.mit.edu	37	12	62749120	62749120	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr12:62749120A>G	ENST00000280377.5	+	8	837	c.779A>G	c.(778-780)aAc>aGc	p.N260S	USP15_ENST00000393654.3_Missense_Mutation_p.N235S|USP15_ENST00000550632.1_3'UTR|USP15_ENST00000353364.3_Missense_Mutation_p.N231S	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	260					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		AGTGTGAAAAACTCAAATTAC	0.333000													10	32					0	0	1	0	0
FAM13C	220965	broad.mit.edu	37	10	61083855	61083855	+	Silent	SNP	A	A	G			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr10:61083855A>G	ENST00000373867.3	-	5	552	c.87T>C	c.(85-87)caT>caC	p.H29H	FAM13C_ENST00000422313.2_Silent_p.H112H|FAM13C_ENST00000373868.2_Silent_p.H112H|FAM13C_ENST00000442566.3_Silent_p.H112H|FAM13C_ENST00000435852.2_Silent_p.H112H|FAM13C_ENST00000468840.2_Silent_p.H29H|FAM13C_ENST00000419214.2_Silent_p.H112H|FAM13C_ENST00000510215.2_5'UTR|FAM13C_ENST00000277705.6_Silent_p.H112H	NM_001166698.1	NP_001160170.1	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	112										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TGGATACCACATGCTCTGTCT	0.493000													5	145					0	0	1	0	0
PRPF6	24148	broad.mit.edu	37	20	62626273	62626273	+	Missense_Mutation	SNP	A	A	G			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr20:62626273A>G	ENST00000535781.1	+	5	554	c.443A>G	c.(442-444)aAg>aGg	p.K148R	ZNF512B_ENST00000217130.3_Intron|ZNF512B_ENST00000450537.1_Intron			O94906	PRP6_HUMAN	pre-mRNA processing factor 6	148					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					TTCCAGAGGAAGTTGGCAGAA	0.517000													3	32					0	0	1	0	0
COG7	91949	broad.mit.edu	37	16	23400369	23400369	+	Missense_Mutation	SNP	G	G	A			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr16:23400369G>A	ENST00000307149.5	-	17	2370	c.2185C>T	c.(2185-2187)Ccg>Tcg	p.P729S		NM_153603.3	NP_705831.1	P83436	COG7_HUMAN	component of oligomeric golgi complex 7	729					intracellular protein transport|protein glycosylation|protein localization in Golgi apparatus|protein stabilization|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|large_intestine(9)|liver(1)|lung(7)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.0401)		GTGCGGGACGGCTGCAGGCCC	0.622000													3	43					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63246575	63246575	+	Silent	SNP	G	G	A			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr14:63246575G>A	ENST00000322893.7	-	10	2158	c.1890C>T	c.(1888-1890)gtC>gtT	p.V630V	KCNH5_ENST00000420622.2_Intron|KCNH5_ENST00000394968.1_Silent_p.V572V	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	630					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TCAGTGCCCGGACGTTCGCAC	0.453000													3	48					0	0	1	0	0
CSTF1	1477	broad.mit.edu	37	20	54970613	54970613	+	Missense_Mutation	SNP	A	A	T			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr20:54970613A>T	ENST00000217109.4	+	2	357	c.5A>T	c.(4-6)tAc>tTc	p.Y2F	CSTF1_ENST00000493039.1_3'UTR	NM_001033521.1|NM_001324.2	NP_001028693.1|NP_001315.1	Q05048	CSTF1_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa	2					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	15			Colorectal(105;0.202)			TCCAAGATGTACAGAACCAAA	0.493000													3	28					0	0	1	0	0
LOC100294341	100294341	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													4	58					0	0	1	0	0
ZNF823	55552	broad.mit.edu	37	19	11833345	11833345	+	Missense_Mutation	SNP	T	T	C			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr19:11833345T>C	ENST00000341191.6	-	4	1157	c.1004A>G	c.(1003-1005)aAg>aGg	p.K335R	ZNF823_ENST00000545749.1_Missense_Mutation_p.K153R	NM_001080493.2	NP_001073962.1	P16415	ZN823_HUMAN	zinc finger protein 823	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)	26						CCCACATATCTTACATTTATG	0.418000										HNSCC(68;0.2)			51	66					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120612003	120612004	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr1:120612003_120612004delGG	ENST00000256646.2	-	1	236_237	c.17_18delCC	c.(16-18)cfs	p.P6fs		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	6					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity	p.P6fs*27(2)		breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACAGCAGAGCGGGGCGCAGGGC	0.762			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				7	6	---	---	---	---					
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121137791	121137793	+	RNA	DEL	CCA	CCA	-	rs28552466	by1000genomes	TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr1:121137791_121137793delCCA	ENST00000437515.1	-	0	329																											ATTTCGCCCTCCACCGCCGCCGC	0.631													6	6	---	---	---	---					
ITPRIPL1	150771	broad.mit.edu	37	2	96992793	96992795	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr2:96992793_96992795delGAG	ENST00000361124.4	+	1	859_861	c.448_450delGAG	c.(448-450)del	p.E155del	ITPRIPL1_ENST00000542887.1_In_Frame_Del_p.E139del|ITPRIPL1_ENST00000439118.2_In_Frame_Del_p.E147del|ITPRIPL1_ENST00000536814.1_In_Frame_Del_p.E139del	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	147						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTCCAGCAGTGAGGAGGAGGAGG	0.532													7	59	---	---	---	---					
SATB1	6304	broad.mit.edu	37	3	18391140	18391160	+	In_Frame_Del	DEL	TGCTGCTGCTGCTGTTGCTGT	TGCTGCTGCTGCTGTTGCTGT	-			TCGA-WB-A81W-01A-11D-A35I-08	TCGA-WB-A81W-10A-01D-A35G-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8d9f4548-e7f8-4f9a-a6ce-f5d3d81570ee	fdc71fac-fc42-48b8-8615-5ec0658f2124	g.chr3:18391140_18391160delTGCTGCTGCTGCTGTTGCTGT	ENST00000338745.6	-	11	3528_3548	c.1794_1814delACAGCAACAGCAGCAGCAGCA	c.(1792-1815)cag>ca	p.QQQQQQQQ598del	SATB1_ENST00000454909.2_In_Frame_Del_p.QQQQQQQQ598del|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000417717.2_In_Frame_Del_p.QQQQQQQQ630del	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	598	Poly-Gln.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						TGCctgctgctgctgctgctgctgttgctgttgctgctgct	0.597													5	9	---	---	---	---