Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRPA1	8989	broad.mit.edu	37	8	72967934	72967934	+	Missense_Mutation	SNP	G	G	T			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr8:72967934G>T	ENST00000262209.4	-	11	1558	c.1351C>A	c.(1351-1353)Cat>Aat	p.H451N	RP11-383H13.1_ENST00000457356.4_3'UTR	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	451						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	GCTGCAAAATGCAGAGGTGAT	0.373000													12	55					3.07112e-06	3.33436e-06	1	1	0
CLCN1	1180	broad.mit.edu	37	7	143029831	143029831	+	Missense_Mutation	SNP	A	A	C			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr7:143029831A>C	ENST00000343257.2	+	12	1353	c.1266A>C	c.(1264-1266)gaA>gaC	p.E422D		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	422					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					TGCCCCGCGAAGCCATCAGTA	0.527000													73	92					0	0	1	0	0
PARK2	5071	broad.mit.edu	37	6	162622178	162622178	+	Silent	SNP	C	C	T			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr6:162622178C>T	ENST00000366898.1	-	4	621	c.519G>A	c.(517-519)acG>acA	p.T173T	PARK2_ENST00000338468.3_Intron|PARK2_ENST00000366892.1_Silent_p.T173T|PARK2_ENST00000366894.1_5'UTR|PARK2_ENST00000366896.1_Intron|PARK2_ENST00000366897.1_Silent_p.T173T	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	173					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		TCAAGGTGAGCGTTGCCTGCC	0.463000													23	45					0	0	1	0	0
KRTAP1-3	81850	broad.mit.edu	37	17	39190675	39190675	+	Nonsense_Mutation	SNP	G	G	T			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr17:39190675G>T	ENST00000344363.5	-	1	432	c.399C>A	c.(397-399)tgC>tgA	p.C133*		NM_030966.1	NP_112228.1	Q8IUG1	KRA13_HUMAN	keratin associated protein 1-3	143						extracellular region|keratin filament	structural constituent of epidermis			cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(6)	12		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGCTGGCAGCAGGTTGGGG	0.672000													11	25					3.86212e-05	4.07668e-05	1	1	0
FLVCR1	28982	broad.mit.edu	37	1	213032441	213032441	+	Missense_Mutation	SNP	T	T	G			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr1:213032441T>G	ENST00000366971.4	+	1	845	c.647T>G	c.(646-648)tTc>tGc	p.F216C		NM_014053.3	NP_054772.1	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular receptor 1	216					cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(2)	12				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		GCCCAGGTGTTCATCCTGGGC	0.607000													21	21					0	0	1	0	0
DAO	1610	broad.mit.edu	37	12	109288095	109288095	+	Silent	SNP	G	G	A			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr12:109288095G>A	ENST00000228476.3	+	7	768	c.564G>A	c.(562-564)gcG>gcA	p.A188A	DAO_ENST00000551281.1_Silent_p.A122A	NM_001917.4	NP_001908.3	P14920	OXDA_HUMAN	D-amino-acid oxidase	188					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|skin(1)	26						GGGCTGGGGCGCTACAACGAG	0.572000													6	15					0	0	1	0	0
AK8	158067	broad.mit.edu	37	9	135698626	135698626	+	Silent	SNP	G	G	T			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr9:135698626G>T	ENST00000298545.3	-	9	1376	c.855C>A	c.(853-855)gcC>gcA	p.A285A	AK8_ENST00000477396.1_5'UTR	NM_152572.2	NP_689785.1	Q96MA6	KAD8_HUMAN	adenylate kinase 8	285	Adenylate kinase.					cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			NS(1)|kidney(2)|large_intestine(4)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(2)	23						CCAGGAGGGCGGCCTGCAGAC	0.627000													4	127					0.150653	0.150653	1	1	0
EIF3C	8663	broad.mit.edu	37	16	28734595	28734595	+	Missense_Mutation	SNP	A	A	G			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr16:28734595A>G	ENST00000331666.6	+	9	1073	c.887A>G	c.(886-888)aAt>aGt	p.N296S	EIF3C_ENST00000566866.1_Missense_Mutation_p.N296S|EIF3C_ENST00000564243.1_Missense_Mutation_p.N286S|EIF3C_ENST00000395587.1_Missense_Mutation_p.N296S|EIF3C_ENST00000566501.1_Missense_Mutation_p.N296S			Q99613	EIF3C_HUMAN	eukaryotic translation initiation factor 3, subunit C	296						cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(5)|skin(1)	6						GAGGAGGACAATGAAGGCGGG	0.532000													144	556					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10107082	10107082	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr3:10107082G>A	ENST00000287647.3	+	24	2266	c.2173G>A	c.(2173-2175)Gtg>Atg	p.V725M	FANCD2_ENST00000383806.1_Missense_Mutation_p.V725M|FANCD2_ENST00000419585.1_Missense_Mutation_p.V725M|FANCD2_ENST00000383807.1_Missense_Mutation_p.V725M	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	725					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TCTCAGATTGGTGTCTCCGCT	0.438000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				28	56					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813675	106813675	+	Silent	SNP	G	G	A			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr8:106813675G>A	ENST00000407775.2	+	8	1615	c.1365G>A	c.(1363-1365)gaG>gaA	p.E455E	RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000520492.1_Silent_p.E323E|ZFPM2_ENST00000517361.1_Silent_p.E323E|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000378472.4_Silent_p.E186E	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	455					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AGAGACCAGAGATACAGCCTA	0.443000													19	31					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115391645	115391645	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr10:115391645C>T	ENST00000369358.4	-	17	1955	c.1711G>A	c.(1711-1713)Gcc>Acc	p.A571T	NRAP_ENST00000359988.3_Missense_Mutation_p.A571T|NRAP_ENST00000369360.3_Missense_Mutation_p.A536T|NRAP_ENST00000360478.3_Missense_Mutation_p.A536T			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	571						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding	p.A571T(2)		autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GAGGCTTTGGCGGCCAGCAGA	0.453000													4	112					0	0	1	0	0
IL1A	3552	broad.mit.edu	37	2	113539246	113539246	+	Missense_Mutation	SNP	C	C	T	rs3783531	byFrequency	TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr2:113539246C>T	ENST00000263339.3	-	4	409	c.254G>A	c.(253-255)cGg>cAg	p.R85Q		NM_000575.3	NP_000566.3	P01583	IL1A_HUMAN	interleukin 1, alpha	85			R -> Q (in dbSNP:rs3783531).		anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			breast(2)|large_intestine(1)|lung(9)	12						TAAACTCAACCGTCTCTTCTT	0.453000													5	194					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126748827	126748827	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr3:126748827G>A	ENST00000251772.4	+	27	4981	c.4912G>A	c.(4912-4914)Gac>Aac	p.D1638N	PLXNA1_ENST00000393409.2_Missense_Mutation_p.D1661N			Q9UIW2	PLXA1_HUMAN	plexin A1	1661					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		GAAGAACCACGACCACCTGGA	0.667000													35	46					0	0	1	0	0
MRPL52	122704	broad.mit.edu	37	14	23299461	23299461	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr14:23299461C>T	ENST00000355151.5	+	3	185	c.155C>T	c.(154-156)gCg>gTg	p.A52V	MRPL52_ENST00000432849.3_Missense_Mutation_p.A51V|MRPL52_ENST00000557221.1_Missense_Mutation_p.R2W|MRPL52_ENST00000556840.1_5'UTR|MRPL52_ENST00000311892.6_5'UTR|MRPL52_ENST00000555536.1_5'UTR|MRPL52_ENST00000553711.1_5'UTR|MRPL52_ENST00000555345.1_5'UTR|MRPL52_ENST00000461594.1_3'UTR|MRPL52_ENST00000397505.2_Missense_Mutation_p.A52V|MRPL52_ENST00000397496.3_Missense_Mutation_p.A51V	NM_178336.2|NM_180982.2|NM_181306.2	NP_848026.1|NP_851313.1|NP_851823.1	Q86TS9	RM52_HUMAN	mitochondrial ribosomal protein L52	52					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome					all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		TGGTCATATGCGGGTAAGCGC	0.602000													4	107					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54806426	54806426	+	Missense_Mutation	SNP	C	C	A	rs147144028	by1000genomes	TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr6:54806426C>A	ENST00000306858.7	+	5	2773	c.2657C>A	c.(2656-2658)gCc>gAc	p.A886D		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	886										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					GATGCCTCTGCCCCAAGATTT	0.448000													31	35					5.90632e-09	6.80122e-09	1	1	0
TFB1M	51106	broad.mit.edu	37	6	155632395	155632395	+	Missense_Mutation	SNP	C	C	G			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr6:155632395C>G	ENST00000367166.4	-	2	267	c.212G>C	c.(211-213)aGa>aCa	p.R71T	TFB1M_ENST00000480390.1_5'UTR	NM_016020.3	NP_057104.2	Q8WVM0	TFB1M_HUMAN	transcription factor B1, mitochondrial	71					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial nucleoid	DNA binding|protein binding|rRNA (adenine-N6,N6-)-dimethyltransferase activity			lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;1.48e-12)|BRCA - Breast invasive adenocarcinoma(81;0.0131)		AAGAATAGATCTTGTGATTCC	0.428000													33	47					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100684108	100684108	+	Silent	SNP	C	C	A			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr7:100684108C>A	ENST00000306151.4	+	3	9475	c.9411C>A	c.(9409-9411)acC>acA	p.T3137T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3137	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CACCTGTGACCACTTCTACTG	0.493000													7	462					0.00448238	0.00460353	1	1	0
RYR2	6262	broad.mit.edu	37	1	237893572	237893572	+	Silent	SNP	C	C	T			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr1:237893572C>T	ENST00000366574.2	+	77	11168	c.10851C>T	c.(10849-10851)gtC>gtT	p.V3617V	RYR2_ENST00000360064.6_Silent_p.V3615V|RYR2_ENST00000542537.1_Silent_p.V3601V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3617					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATCGGGCTGTCAATCTCTTTC	0.333000													13	21					0	0	1	0	0
FAM83D	81610	broad.mit.edu	37	20	37580707	37580707	+	Silent	SNP	G	G	A			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr20:37580707G>A	ENST00000217429.4	+	4	1433	c.1392G>A	c.(1390-1392)acG>acA	p.T464T		NM_030919.2	NP_112181.2	Q9H4H8	FA83D_HUMAN	family with sequence similarity 83, member D	434	Ser-rich.				cell division|mitosis	cytoplasm|spindle pole				endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)|stomach(1)	28		Myeloproliferative disorder(115;0.00878)				CTCAAACCACGATTTGGTCCA	0.493000													29	39					0	0	1	0	0
YME1L1	10730	broad.mit.edu	37	10	27412531	27412531	+	Silent	SNP	G	G	A			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr10:27412531G>A	ENST00000326799.3	-	11	1366	c.1218C>T	c.(1216-1218)tcC>tcT	p.S406S	YME1L1_ENST00000463270.1_5'UTR|YME1L1_ENST00000376016.3_Silent_p.S349S|YME1L1_ENST00000375972.3_Silent_p.S316S	NM_139312.2	NP_647473.1	Q96TA2	YMEL1_HUMAN	YME1-like 1 ATPase	406					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23						CATCAAATTCGGATCCAGAAG	0.438000													48	88					0	0	1	0	0
ITGA2B	3674	broad.mit.edu	37	17	42458348	42458348	+	Missense_Mutation	SNP	C	C	A			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr17:42458348C>A	ENST00000262407.5	-	13	1323	c.1292G>T	c.(1291-1293)aGg>aTg	p.R431M	ITGA2B_ENST00000377068.3_Missense_Mutation_p.R116M|ITGA2B_ENST00000353281.4_Missense_Mutation_p.R431M	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	431					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity	p.R431M(1)		biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GGGACGTGACCTCAGCCCCTC	0.617000													21	20					1.87028e-06	2.09032e-06	1	1	0
SLC44A4	80736	broad.mit.edu	37	6	31833774	31833774	+	Missense_Mutation	SNP	T	T	C			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr6:31833774T>C	ENST00000544672.1	-	14	1431	c.1135A>G	c.(1135-1137)Aac>Gac	p.N379D	SLC44A4_ENST00000229729.6_Missense_Mutation_p.N455D|SLC44A4_ENST00000375562.4_Missense_Mutation_p.N413D	NM_001178045.1	NP_001171516.1	Q53GD3	CTL4_HUMAN	solute carrier family 44, member 4	455				LATSGQPQ -> PLPTQPATLG (in Ref. 4; AAD21813 and 5; BAB63296).		integral to membrane|plasma membrane	choline transmembrane transporter activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(1)|urinary_tract(2)	35					Choline(DB00122)	AGTACCCAGTTAAGGGTCCAG	0.557000													3	86					0	0	1	0	0
MMP17	4326	broad.mit.edu	37	12	132329952	132329952	+	Missense_Mutation	SNP	G	G	A			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr12:132329952G>A	ENST00000360564.1	+	8	1264	c.1162G>A	c.(1162-1164)Gtg>Atg	p.V388M	MMP17_ENST00000535004.1_5'UTR|MMP17_ENST00000535291.1_Missense_Mutation_p.V304M	NM_016155.4	NP_057239.4	Q9ULZ9	MMP17_HUMAN	matrix metallopeptidase 17 (membrane-inserted)	388	Hemopexin-like 2.				proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)	5	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		CGTGGACGCCGTGTACGAGCG	0.692000													10	9					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152732860	152732860	+	Missense_Mutation	SNP	C	C	T			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr1:152732860C>T	ENST00000368773.1	+	2	854	c.796C>T	c.(796-798)Ccc>Tcc	p.P266S	KPRP_ENST00000606109.1_Missense_Mutation_p.P266S	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	266	Pro-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCAGCTTTTCCCCCGCAGCTG	0.617000													20	32					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	68					0	0	1	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328681	88328681	+	Silent	SNP	T	T	C			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr13:88328681T>C	ENST00000325089.6	+	2	1257	c.1038T>C	c.(1036-1038)tcT>tcC	p.S346S	SLITRK5_ENST00000400028.3_Silent_p.S105S	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	346						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GCCCCACCTCTCGGCAGCCCT	0.587000													43	59					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204926875	204926875	+	Silent	SNP	C	C	T			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr1:204926875C>T	ENST00000367172.4	+	8	955	c.627C>T	c.(625-627)acC>acT	p.T209T	NFASC_ENST00000367171.4_Silent_p.T209T|NFASC_ENST00000338515.6_Silent_p.T209T|NFASC_ENST00000367169.4_Silent_p.T209T|NFASC_ENST00000513543.1_Silent_p.T203T|NFASC_ENST00000539706.1_Silent_p.T203T|NFASC_ENST00000403080.1_Silent_p.T209T|NFASC_ENST00000401399.1_Silent_p.T209T|NFASC_ENST00000404076.1_Silent_p.T203T|NFASC_ENST00000367170.4_Silent_p.T209T|NFASC_ENST00000338586.6_Silent_p.T209T|NFASC_ENST00000404907.1_Silent_p.T203T|NFASC_ENST00000360049.4_Silent_p.T203T|NFASC_ENST00000339876.6_Silent_p.T209T			O94856	NFASC_HUMAN	neurofascin	209	Ig-like C2-type 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding	p.T209T(1)|p.T203T(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			ACATGCAGACCGACTACAGTT	0.537000													11	73					0	0	1	0	0
GGPS1	9453	broad.mit.edu	37	1	235505067	235505067	+	Silent	SNP	C	C	T			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr1:235505067C>T	ENST00000282841.5	+	3	347	c.115C>T	c.(115-117)Ctg>Ttg	p.L39L	GGPS1_ENST00000358966.2_Silent_p.L39L|GGPS1_ENST00000488594.1_Silent_p.L39L|GGPS1_ENST00000476121.1_Silent_p.L39L|GGPS1_ENST00000391855.2_5'UTR			O95749	GGPPS_HUMAN	geranylgeranyl diphosphate synthase 1	39					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	dimethylallyltranstransferase activity|farnesyltranstransferase activity|geranyltranstransferase activity|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	8	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;1.39e-05)			TAATCATTGGCTGAAAGTTCC	0.328000													21	68					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10315826	10315826	+	Missense_Mutation	SNP	G	G	A	rs150633264		TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr17:10315826G>A	ENST00000403437.2	-	14	1371	c.1277C>T	c.(1276-1278)gCg>gTg	p.A426V	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	426	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						AGCACCCACCGCATTGTACAC	0.498000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				11	290					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	67					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112175907	112175907	+	Nonsense_Mutation	SNP	C	C	G			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr5:112175907C>G	ENST00000457016.1	+	16	4996	c.4616C>G	c.(4615-4617)tCa>tGa	p.S1539*	CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000257430.4_Nonsense_Mutation_p.S1539*|APC_ENST00000508376.2_Nonsense_Mutation_p.S1539*			P25054	APC_HUMAN	adenomatous polyposis coli	1539	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E1540fs*4(1)|p.K1192fs*3(1)|p.?(1)|p.S1539*(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		GAAACAGAATCAGAGCAGCCT	0.368000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			35	16					0	0	1	0	0
ORC2	4999	broad.mit.edu	37	2	201822858	201822858	+	Splice_Site	SNP	T	T	C			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr2:201822858T>C	ENST00000234296.2	-	3	240		c.e3-2		ORC2_ENST00000467605.1_Intron	NM_006190.4	NP_006181.1	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2						cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	20						GTTGCCAACCTAAACAAAAAC	0.313000													3	82					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128844792	128844792	+	Missense_Mutation	SNP	T	T	C			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr11:128844792T>C	ENST00000310343.9	-	20	2257	c.2258A>G	c.(2257-2259)aAt>aGt	p.N753S	ARHGAP32_ENST00000392657.3_Missense_Mutation_p.N404S|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.N404S|ARHGAP32_ENST00000524655.1_Missense_Mutation_p.N679S	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	753					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						ATGAGGCAGATTATCATAGGA	0.498000													22	39					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183513586	183513589	+	Frame_Shift_Del	DEL	CCCC	CCCC	-			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr1:183513586_183513589delCCCC	ENST00000367537.3	+	16	2085_2088	c.1890_1893delCCCC	c.(1888-1893)atfs	p.IP630fs	SMG7_ENST00000507469.1_Frame_Shift_Del_p.IP601fs|SMG7_ENST00000456731.2_Frame_Shift_Del_p.IP559fs|SMG7_ENST00000508461.1_Frame_Shift_Del_p.IP605fs|SMG7_ENST00000515829.2_Frame_Shift_Del_p.IP601fs|SMG7_ENST00000347615.2_Frame_Shift_Del_p.IP647fs			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	647					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						CCCAGTTCATCCCCATTCATCACC	0.426													32	80	---	---	---	---					
LRRN1	57633	broad.mit.edu	37	3	3887021	3887021	+	Frame_Shift_Del	DEL	A	A	-			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr3:3887021delA	ENST00000319331.3	+	2	1457	c.696delA	c.(694-696)ggfs	p.G232fs	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	232						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		ATATTCCTGGAAATGCTTTGG	0.408													9	229	---	---	---	---					
DBR1	51163	broad.mit.edu	37	3	137880741	137880743	+	In_Frame_Del	DEL	TCG	TCG	-	rs2622736	byFrequency	TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr3:137880741_137880743delTCG	ENST00000260803.4	-	8	1776_1778	c.1623_1625delCGA	c.(1621-1626)gat>ga	p.DD541del	DBR1_ENST00000505015.2_In_Frame_Del_p.DD307del	NM_016216.3	NP_057300.2	Q9UK59	DBR1_HUMAN	debranching RNA lariats 1	541						nucleus	metal ion binding|RNA lariat debranching enzyme activity			NS(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	15						TTAAGCTGCATCGTCATCATCAT	0.394													10	162	---	---	---	---					
DOCK2	1794	broad.mit.edu	37	5	169188601	169188601	+	Frame_Shift_Del	DEL	A	A	-			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr5:169188601delA	ENST00000256935.8	+	25	2606	c.2526delA	c.(2524-2526)atfs	p.I842fs	DOCK2_ENST00000540750.1_5'UTR|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Frame_Shift_Del_p.I334fs	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	842					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGAATGAGATAGTCCAGAGCA	0.488													65	111	---	---	---	---					
PXN	5829	broad.mit.edu	37	12	120661542	120661542	+	Frame_Shift_Del	DEL	C	C	-			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr12:120661542delC	ENST00000536957.1	-	3	804	c.329delG	c.(328-330)gtfs	p.G110fs	PXN_ENST00000424649.2_Frame_Shift_Del_p.G112fs|PXN_ENST00000267257.7_Frame_Shift_Del_p.G112fs|PXN_ENST00000458477.2_5'UTR|PXN_ENST00000228307.7_Frame_Shift_Del_p.G112fs|PXN_ENST00000538144.1_5'UTR			P49023	PAXI_HUMAN	paxillin	112					cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTCCTCCTCACCCACTCGGGA	0.612													2	4	---	---	---	---					
DNM1P47	0	broad.mit.edu	37	15	102292874	102292876	+	RNA	DEL	CTC	CTC	-			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr15:102292874_102292876delCTC	ENST00000561463.1	+	0	920_922																											AGTTCATCTTCTCAGAGCTGCTG	0.581													3	4	---	---	---	---					
PSMB6	5694	broad.mit.edu	37	17	4699584	4699584	+	Frame_Shift_Del	DEL	C	C	-			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr17:4699584delC	ENST00000270586.3	+	1	146	c.95delC	c.(94-96)tcfs	p.S32fs		NM_001270481.1|NM_002798.2	NP_001257410.1|NP_002789.1	P28072	PSB6_HUMAN	proteasome (prosome, macropain) subunit, beta type, 6	32					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			endometrium(3)|large_intestine(3)|lung(2)|ovary(2)|prostate(1)	11						CGAGAAGTTTCCACTGGGGTG	0.607													2	4	---	---	---	---					
BCAM	4059	broad.mit.edu	37	19	45324017	45324017	+	Frame_Shift_Del	DEL	G	G	-			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr19:45324017delG	ENST00000270233.6	+	14	1841	c.1819delG	c.(1819-1821)gcfs	p.G607fs		NM_001013257.2|NM_005581.4	NP_001013275.1|NP_005572.2	P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	607					cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				AGAGCAGACCGGCCTTCTCAT	0.726													2	4	---	---	---	---					
SCARF2	0	broad.mit.edu	37	22	20779786	20779786	+	Frame_Shift_Del	DEL	G	G	-			TCGA-EJ-7325-01B-11D-A32B-08	TCGA-EJ-7325-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	57c67ced-cab5-4e66-a6b8-04c020bd4a3e	16fc1662-ec00-4bfc-abf6-ce18b7ae0f4d	g.chr22:20779786delG	ENST00000405555.3	-	11	2547	c.2477delC	c.(2476-2478)ggfs	p.A827fs	SCARF2_ENST00000266214.5_Frame_Shift_Del_p.A832fs	NM_182895.2	NP_878315.1	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2	828	Pro-rich.				cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	10	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GTCGGTCGCCGCCTTCTCAGG	0.746													2	4	---	---	---	---