Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													3	59					0	0	1	0	0
FAM170A	340069	broad.mit.edu	37	5	118970330	118970330	+	Missense_Mutation	SNP	C	C	A			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr5:118970330C>A	ENST00000515256.1	+	3	1059	c.887C>A	c.(886-888)gCa>gAa	p.A296E				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	296	Glu-rich.					intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						aaaccagaagcaaaggaggag	0.527000													11	60					0.000978159	0.00102964	1	1	0
AR	367	broad.mit.edu	37	X	66905872	66905872	+	Missense_Mutation	SNP	G	G	A	rs137852569		TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chrX:66905872G>A	ENST00000374690.3	+	3	2313	c.1789G>A	c.(1789-1791)Gcc>Acc	p.A597T	AR_ENST00000396044.3_Missense_Mutation_p.A597T|AR_ENST00000504326.1_Missense_Mutation_p.A597T|AR_ENST00000513847.1_3'UTR|AR_ENST00000396043.2_Missense_Mutation_p.A65T	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	596	Interaction with HIPK3 (By similarity).		S -> G (in PAIS; high dissociation rate; associated with P-617 in a PAIS patient; partially restores DNA-binding activity of P-617 mutant receptors).|S -> T (in a patient with severe hypospadias).		cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	GTACCTGTGCGCCAGCAGAAA	0.413000									Androgen Insensitivity Syndrome				26	8					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32561297	32561297	+	Silent	SNP	A	A	G			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr14:32561297A>G	ENST00000345122.3	+	2	1737	c.1422A>G	c.(1420-1422)gtA>gtG	p.V474V	ARHGAP5_ENST00000556611.1_Silent_p.V474V|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000432921.1_Silent_p.V474V|ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000539826.2_Silent_p.V474V	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	474	FF 3.				cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		GCAAAGAGGTATATGGTAGGC	0.373000													3	70					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													5	50					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7780626	7780626	+	Missense_Mutation	SNP	C	C	T			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr10:7780626C>T	ENST00000358415.4	+	16	2166	c.2000C>T	c.(1999-2001)cCg>cTg	p.P667L	ITIH2_ENST00000379587.4_Missense_Mutation_p.P656L	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	667					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						GATTCCACCCCGTCTTGGGCC	0.527000													27	36					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													5	39					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72821615	72821615	+	Silent	SNP	G	G	A			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr16:72821615G>A	ENST00000268489.5	-	10	11232	c.10560C>T	c.(10558-10560)ggC>ggT	p.G3520G	ZFHX3_ENST00000397992.5_Silent_p.G2606G|AC004943.1_ENST00000584072.1_RNA	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3520	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccgccaccgccgc	0.706000													4	26					0	0	1	0	0
ABHD16A	7920	broad.mit.edu	37	6	31668722	31668722	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr6:31668722G>A	ENST00000395952.3	-	4	502	c.340C>T	c.(340-342)Cga>Tga	p.R114*	XXbac-BPG32J3.20_ENST00000461287.1_3'UTR|ABHD16A_ENST00000375842.4_5'UTR|ABHD16A_ENST00000440843.2_Nonsense_Mutation_p.R81*|ABHD16A_ENST00000538874.1_Silent_p.S15S	NM_021160.2	NP_066983.1	O95870	ABHGA_HUMAN	abhydrolase domain containing 16A	114						integral to membrane	hydrolase activity|protein binding			endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	10						CACCTACCTCGGAGGCAGGCC	0.483000													15	25					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116632180	116632180	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr8:116632180C>A	ENST00000395715.3	-	3	722	c.145G>T	c.(145-147)Gaa>Taa	p.E49*	TRPS1_ENST00000220888.5_Nonsense_Mutation_p.E36*|TRPS1_ENST00000519674.1_Nonsense_Mutation_p.E36*|TRPS1_ENST00000519076.1_Nonsense_Mutation_p.E36*|TRPS1_ENST00000520276.1_Nonsense_Mutation_p.E40*	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	36					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GCAGAAAATTCTTTGTTCTTT	0.448000									Langer-Giedion syndrome				15	49					0.00244969	0.00251251	1	1	0
IGHV2-26	0	broad.mit.edu	37	14	106757786	106757786	+	RNA	SNP	G	G	A			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr14:106757786G>A	ENST00000390611.2	-	0	244																											TTCGTCATTCGAAAAAATGTG	0.532000													6	70					0	0	1	0	0
KRT35	3886	broad.mit.edu	37	17	39635635	39635635	+	Silent	SNP	C	C	T			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr17:39635635C>T	ENST00000246639.2	-	3	717	c.585G>A	c.(583-585)aaG>aaA	p.K195K	KRT35_ENST00000393989.1_Silent_p.K225K			Q92764	KRT35_HUMAN	keratin 35	225	Coil 1B.|Rod.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.000286)				GCAGCTCCTCCTTCAGGGACT	0.602000													3	74					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175898876	175898876	+	Missense_Mutation	SNP	C	C	A	rs138923714	byFrequency	TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr4:175898876C>A	ENST00000359240.3	+	5	2870	c.2200C>A	c.(2200-2202)Cct>Act	p.P734T	ADAM29_ENST00000514159.1_Missense_Mutation_p.P734T|ADAM29_ENST00000404450.4_Missense_Mutation_p.P734T|RP13-577H12.2_ENST00000507525.1_RNA|ADAM29_ENST00000445694.1_Missense_Mutation_p.P734T	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	734					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CCAGAGTCAACCTTGGGTGAT	0.493000													44	50					1.48734e-19	1.60793e-19	1	1	0
ENPP5	59084	broad.mit.edu	37	6	46129452	46129452	+	Missense_Mutation	SNP	G	G	A			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr6:46129452G>A	ENST00000371383.2	-	5	1305	c.1045C>T	c.(1045-1047)Cat>Tat	p.H349Y	ENPP5_ENST00000230565.3_Missense_Mutation_p.H349Y			Q9UJA9	ENPP5_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)	349						extracellular region|integral to membrane	hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	12						AATATTGGATGCATATCTGCT	0.388000													84	172					0	0	1	0	0
PARP11	57097	broad.mit.edu	37	12	3923277	3923277	+	Missense_Mutation	SNP	T	T	A			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr12:3923277T>A	ENST00000228820.4	-	7	770	c.626A>T	c.(625-627)gAa>gTa	p.E209V	PARP11_ENST00000476985.1_5'UTR|PARP11_ENST00000397096.2_Missense_Mutation_p.E202V|PARP11_ENST00000447133.3_Missense_Mutation_p.E128V|PARP11_ENST00000427057.2_Missense_Mutation_p.E128V	NM_020367.4	NP_065100.2	Q9NR21	PAR11_HUMAN	poly (ADP-ribose) polymerase family, member 11	202	PARP catalytic.						NAD+ ADP-ribosyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)	17			all cancers(3;1.58e-07)|OV - Ovarian serous cystadenocarcinoma(31;0.00287)|GBM - Glioblastoma multiforme(3;0.0141)|COAD - Colon adenocarcinoma(12;0.0264)			TTCCACAAATTCACTGCTGGT	0.368000													8	55					0	0	1	0	0
GOLGA6L7P	0	broad.mit.edu	37	15	29092219	29092219	+	RNA	SNP	C	C	T	rs141516940	by1000genomes	TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr15:29092219C>T	ENST00000569815.1	-	0	296					NR_047567.1																						CATCCTCAGGCGAGTGGCAGC	0.552000													19	15					0	0	1	0	0
DAAM2	23500	broad.mit.edu	37	6	39869131	39869131	+	Silent	SNP	C	C	T			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr6:39869131C>T	ENST00000538976.1	+	24	3044	c.2862C>T	c.(2860-2862)gaC>gaT	p.D954D	DAAM2_ENST00000398904.2_Silent_p.D955D|DAAM2_ENST00000274867.4_Silent_p.D955D	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	955	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					TGCAGCCAGACGAATTCTTTG	0.577000													6	161					0	0	1	0	0
ANGPT2	285	broad.mit.edu	37	8	6360776	6360776	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr8:6360776C>T	ENST00000325203.5	-	9	1811	c.1337G>A	c.(1336-1338)tGg>tAg	p.W446*	ANGPT2_ENST00000415216.1_Nonsense_Mutation_p.W445*|MCPH1_ENST00000344683.5_Intron|ANGPT2_ENST00000338312.6_Nonsense_Mutation_p.W394*			O15123	ANGP2_HUMAN	angiopoietin 2	446	Fibrinogen C-terminal.				angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)		TGCATCAAACCACCAGCCTGT	0.468000													9	92					0	0	1	0	0
CEP120	153241	broad.mit.edu	37	5	122682431	122682431	+	Missense_Mutation	SNP	G	G	C			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr5:122682431G>C	ENST00000306467.5	-	20	3047	c.2743C>G	c.(2743-2745)Caa>Gaa	p.Q915E	CEP120_ENST00000306481.6_Missense_Mutation_p.Q889E|CEP120_ENST00000328236.5_Missense_Mutation_p.Q915E			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	915						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						TATTGTTTTTGCTCTTGTTGC	0.393000													30	44					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98844684	98844684	+	Missense_Mutation	SNP	T	T	C			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr2:98844684T>C	ENST00000477737.1	+	15	2243	c.2039T>C	c.(2038-2040)tTa>tCa	p.L680S		NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	680	VWFA.									NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CTGACTCTTTTAGTTAAGGAA	0.368000													29	45					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22661272	22661272	+	RNA	SNP	C	C	T			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr22:22661272C>T	ENST00000426066.1	+	0	360					NR_027293.1																						CTGGGATGTACGTCTGCGTTG	0.488000													3	50					0	0	1	0	0
ADAM21P1	0	broad.mit.edu	37	14	70713782	70713782	+	RNA	SNP	A	A	G	rs114580810	by1000genomes	TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr14:70713782A>G	ENST00000530196.1	-	0	736					NR_003951.1																						GTCACCAGCAAATTTTGGTTC	0.443000													6	73					0	0	1	0	0
DYM	54808	broad.mit.edu	37	18	46783426	46783426	+	Missense_Mutation	SNP	C	C	T			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr18:46783426C>T	ENST00000269445.6	-	13	1871	c.1414G>A	c.(1414-1416)Gca>Aca	p.A472T	DYM_ENST00000442713.2_Missense_Mutation_p.A282T	NM_017653.3	NP_060123.3	Q7RTS9	DYM_HUMAN	dymeclin	472						Golgi apparatus				NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	18						CGAAACTGTGCCGACATATTT	0.393000													27	34					0	0	1	0	0
DBX2	440097	broad.mit.edu	37	12	45417627	45417627	+	Missense_Mutation	SNP	G	G	A			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr12:45417627G>A	ENST00000332700.6	-	3	721	c.550C>T	c.(550-552)Cgg>Tgg	p.R184W		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	184						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		ATGCCCCTCCGAGCTTTGGAA	0.433000													7	70					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46862423	46862423	+	Silent	SNP	C	C	T			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr17:46862423C>T	ENST00000393382.3	-	13	2043	c.1902G>A	c.(1900-1902)acG>acA	p.T634T	TTLL6_ENST00000433608.2_Silent_p.T327T	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	586						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						GCTTCGCAGACGTCAGCTTGG	0.527000													4	108					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr20:29628300G>A	ENST00000278882.3	+	6	682	c.302G>A	c.(301-303)aGt>aAt	p.S101N	FRG1B_ENST00000439954.2_Missense_Mutation_p.S106N|FRG1B_ENST00000358464.4_Missense_Mutation_p.S101N														p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAAGCAAAAAGTAAAACAGCA	0.358000													5	58					0	0	1	0	0
SLC22A9	114571	broad.mit.edu	37	11	63176239	63176239	+	Silent	SNP	C	C	T			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr11:63176239C>T	ENST00000279178.3	+	9	1738	c.1489C>T	c.(1489-1491)Ctg>Ttg	p.L497L	SLC22A9_ENST00000310969.4_3'UTR	NM_080866.2	NP_543142.2	Q8IVM8	S22A9_HUMAN	solute carrier family 22 (organic anion transporter), member 9	497					transmembrane transport	integral to membrane				breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	18						TTCTCCACCCCTGCCCTGGAT	0.507000													23	41					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													4	49					0	0	1	0	0
PIK3R3	8503	broad.mit.edu	37	1	46546396	46546396	+	Missense_Mutation	SNP	T	T	C			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr1:46546396T>C	ENST00000262741.5	-	2	822	c.133A>G	c.(133-135)Atg>Gtg	p.M45V	PIK3R3_ENST00000423209.1_Missense_Mutation_p.M45V|PIK3R3_ENST00000372006.1_Missense_Mutation_p.M45V|PIK3R3_ENST00000420542.1_Missense_Mutation_p.M45V|PIK3R3_ENST00000354242.4_Missense_Mutation_p.M45V|PIK3R3_ENST00000340332.6_Intron|PIK3R3_ENST00000540385.1_Missense_Mutation_p.M91V	NM_003629.3	NP_003620.3	Q92569	P55G_HUMAN	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	45					insulin receptor signaling pathway|platelet activation|T cell costimulation		1-phosphatidylinositol-3-kinase activity|protein binding			endometrium(1)|large_intestine(5)|lung(6)|prostate(2)	14	Acute lymphoblastic leukemia(166;0.155)					GCTGAAGTCATTGGCTTAGGT	0.403000													7	252					0	0	1	0	0
HNRNPH1	3187	broad.mit.edu	37	5	179043911	179043911	+	Missense_Mutation	SNP	C	C	T			TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr5:179043911C>T	ENST00000356731.5	-	10	2701	c.1166G>A	c.(1165-1167)gGt>gAt	p.G389D	HNRNPH1_ENST00000511300.2_Intron|HNRNPH1_ENST00000510411.1_Intron|HNRNPH1_ENST00000442819.2_Missense_Mutation_p.G389D|HNRNPH1_ENST00000393432.4_Missense_Mutation_p.G389D|HNRNPH1_ENST00000329433.6_Missense_Mutation_p.G389D			P31943	HNRH1_HUMAN	heterogeneous nuclear ribonucleoprotein H1 (H)	389	2 X 16 AA Gly-rich approximate repeats.|2 X 19 AA perfect repeats.				regulation of RNA splicing	actin cytoskeleton|catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|poly(U) RNA binding|protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(4)|skin(1)	14						ATAAGCACCACCGCTTGCTCC	0.353000													25	101					0	0	1	0	0
RP11-252A24.2	0	broad.mit.edu	37	16	74394379	74394380	+	RNA	INS	-	-	A	rs142790741	by1000genomes	TCGA-FC-A8O0-01A-41D-A377-08	TCGA-FC-A8O0-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79086298-47f2-4553-bf73-fc0572aebf2e	c3e0e54f-67a2-4cc7-9b98-51cd1fc1c318	g.chr16:74394379_74394380insA	ENST00000429810.2	-	0	435																											TAGTCATCCTTAAACAAAATTC	0.347													4	4	---	---	---	---