Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_position End_position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_file Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID Genome_Change Annotation_Transcript Transcript_Strand Transcript_Exon Transcript_Position cDNA_Change Codon_Change Protein_Change Other_Transcripts Refseq_mRNA_Id Refseq_prot_Id SwissProt_acc_Id SwissProt_entry_Id Description UniProt_AApos UniProt_Region UniProt_Site UniProt_Natural_Variations UniProt_Experimental_Info GO_Biological_Process GO_Cellular_Component GO_Molecular_Function COSMIC_overlapping_mutations COSMIC_fusion_genes COSMIC_tissue_types_affected COSMIC_total_alterations_in_gene Tumorscape_Amplification_Peaks Tumorscape_Deletion_Peaks TCGAscape_Amplification_Peaks TCGAscape_Deletion_Peaks DrugBank ref_context gc_content CCLE_ONCOMAP_overlapping_mutations CCLE_ONCOMAP_total_mutations_in_gene CGC_Mutation_Type CGC_Translocation_Partner CGC_Tumor_Types_Somatic CGC_Tumor_Types_Germline CGC_Other_Diseases DNARepairGenes_Role FamilialCancerDatabase_Syndromes MUTSIG_Published_Results OREGANNO_ID OREGANNO_Values t_alt_count t_ref_count validation_alt_allele validation_method validation_status validation_tumor_sample pox qox pox_cutoff isArtifactMode oxoGCut EP400 57634 broad.mit.edu 37 12 132547087 132547087 + Silent SNP G G A rs12366766 TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-10A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d 993197fc-ba4c-466d-9cc2-e08c74cd8f45 g.chr12:132547087G>A ENST00000333577.4 + 48 8392 c.8283G>A c.(8281-8283)caG>caA p.Q2761Q EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000332482.4_Silent_p.Q2688Q Q96L91 EP400_HUMAN E1A binding protein p400 2761 Interaction with ZNF42 (By similarity).|Poly-Gln. histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent NuA4 histone acetyltransferase complex|nuclear speck ATP binding|DNA binding|helicase activity p.Q2724Q(16)|p.Q2725Q(1) NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3) 161 all_neural(191;0.0982)|Medulloblastoma(191;0.163) all_epithelial(31;0.198) OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06) agcagcagcagcaacaacagc 0.562000 3 55 0 0 0.150653 0 0 AC024560.3 0 broad.mit.edu 37 3 197348668 197348668 + RNA SNP C C G rs79940815 by1000genomes TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-10A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d 993197fc-ba4c-466d-9cc2-e08c74cd8f45 g.chr3:197348668C>G ENST00000418868.1 - 0 591 NR_003266.2 ACTTGAGGCTCTGTCCACCAA 0.488000 4 107 0 0 0.150653 0 0 LRPPRC 10128 broad.mit.edu 37 2 44153050 44153050 + Silent SNP T T C TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-10A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d 993197fc-ba4c-466d-9cc2-e08c74cd8f45 g.chr2:44153050T>C ENST00000260665.7 - 26 2844 c.2787A>G c.(2785-2787)agA>agG p.R929R NM_133259.3 NP_573566.2 P42704 LPPRC_HUMAN leucine-rich pentatricopeptide repeat containing 929 mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm beta-tubulin binding|microtubule binding|RNA binding p.R929R(1) breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2) 41 all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17) TTGCAACACATCTGTCACAAA 0.413000 6 85 0 0 0.217242 0 0 NOP58 51602 broad.mit.edu 37 2 203149110 203149110 + Nonsense_Mutation SNP G G T TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-10A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d 993197fc-ba4c-466d-9cc2-e08c74cd8f45 g.chr2:203149110G>T ENST00000264279.5 + 5 566 c.340G>T c.(340-342)Gaa>Taa p.E114* NOP58_ENST00000467734.1_3'UTR NM_015934.3 NP_057018.1 Q9Y2X3 NOP58_HUMAN NOP58 ribonucleoprotein 114 cell growth|rRNA processing|snRNP protein import into nucleus box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex protein binding|snoRNA binding p.E114*(1) breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(4)|prostate(2) 16 TGTTGTTAATGAACTTATGAG 0.373000 3 46 0.115264 0.138317 0.115264 1 0 ADAMTS2 9509 broad.mit.edu 37 5 178555106 178555106 + Missense_Mutation SNP C C A TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-10A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d 993197fc-ba4c-466d-9cc2-e08c74cd8f45 g.chr5:178555106C>A ENST00000251582.7 - 17 2572 c.2471G>T c.(2470-2472)gGa>gTa p.G824V NM_014244.4 NP_055059.2 O95450 ATS2_HUMAN ADAM metallopeptidase with thrombospondin type 1 motif, 2 824 Spacer. collagen catabolic process proteinaceous extracellular matrix metalloendopeptidase activity|zinc ion binding p.G824V(2) breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7) 72 all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326) all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211) Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178) GBM - Glioblastoma multiforme(465;0.0473) CCGGGTGTCTCCCACCGGGAT 0.577000 4 59 0.217242 0.244397 0.217242 1 0 EP400 57634 broad.mit.edu 37 12 132547093 132547093 + Silent SNP A A G rs60608267 by1000genomes TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-10A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d 993197fc-ba4c-466d-9cc2-e08c74cd8f45 g.chr12:132547093A>G ENST00000333577.4 + 48 8398 c.8289A>G c.(8287-8289)caA>caG p.Q2763Q EP400_ENST00000389562.2_Silent_p.Q2726Q|EP400_ENST00000330386.6_Silent_p.Q2646Q|EP400_ENST00000389561.2_Silent_p.Q2727Q|EP400_ENST00000332482.4_Silent_p.Q2690Q Q96L91 EP400_HUMAN E1A binding protein p400 2763 Interaction with ZNF42 (By similarity).|Poly-Gln. histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent NuA4 histone acetyltransferase complex|nuclear speck ATP binding|DNA binding|helicase activity p.Q2726Q(9) NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3) 161 all_neural(191;0.0982)|Medulloblastoma(191;0.163) all_epithelial(31;0.198) OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06) agcagcaacaacagcagcagc 0.567000 3 54 0 0 0.150653 0 0 KRTAP4-11 653240 broad.mit.edu 37 17 39274087 39274087 + Missense_Mutation SNP G G C rs141357429 by1000genomes TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-10A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d 993197fc-ba4c-466d-9cc2-e08c74cd8f45 g.chr17:39274087G>C ENST00000391413.2 - 1 519 c.481C>G c.(481-483)Ctg>Gtg p.L161V NM_033059.3 NP_149048.2 Q9BYQ6 KR411_HUMAN keratin associated protein 4-11 161 27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC]. keratin filament p.L161V(1) endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1) 33 Breast(137;0.000496) STAD - Stomach adenocarcinoma(17;0.000371) ACTGGACGCAGGcagcagcag 0.657000 3 14 0 0 0.150653 0 0 TMEM132A 54972 broad.mit.edu 37 11 60696173 60696173 + Missense_Mutation SNP G G T TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-10A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d 993197fc-ba4c-466d-9cc2-e08c74cd8f45 g.chr11:60696173G>T ENST00000005286.4 + 4 760 c.607G>T c.(607-609)Gcc>Tcc p.A203S TMEM132A_ENST00000453848.2_Missense_Mutation_p.A203S NM_017870.3|NM_178031.2 NP_060340.2|NP_821174.1 Q24JP5 T132A_HUMAN transmembrane protein 132A 203 endoplasmic reticulum membrane|Golgi membrane|integral to membrane p.A203S(2) breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3) 32 CACCACACGGGCCGAGCTGGC 0.682000 8 43 0.00307968 0.00395959 0.278610 1 0 RBM15 64783 broad.mit.edu 37 1 110884731 110884731 + Missense_Mutation SNP G G C TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-10A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d 993197fc-ba4c-466d-9cc2-e08c74cd8f45 g.chr1:110884731G>C ENST00000369784.3 + 1 3604 c.2704G>C c.(2704-2706)Ggg>Cgg p.G902R RBM15_ENST00000487146.2_Missense_Mutation_p.G902R|RBM15_ENST00000602849.1_Missense_Mutation_p.G902R NM_022768.4 NP_073605.4 Q96T37 RBM15_HUMAN RNA binding motif protein 15 902 SPOC. interspecies interaction between organisms nucleus nucleotide binding|protein binding|RNA binding p.G902R(1) ovary(3) 3 all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634) BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135) GCAGGCAGCCGGGGTGATCAG 0.552000 T MKL1 acute megakaryocytic leukemia 7 114 0 0 0.248553 0 0 TSSC2 0 broad.mit.edu 37 11 3427765 3427765 + RNA SNP G G C TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-11A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d fd15e363-f9b9-440d-8469-56377f9fa520 g.chr11:3427765G>C ENST00000529482.1 + 0 882 CACACGTCCTGCAGTGGCCTG 0.602000 3 43 0 0 0.115264 0 0 KRTAP4-9 100132386 broad.mit.edu 37 17 39261693 39261693 + Missense_Mutation SNP A A T rs113059833 by1000genomes TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-11A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d fd15e363-f9b9-440d-8469-56377f9fa520 g.chr17:39261693A>T ENST00000391415.1 + 1 110 c.53A>T c.(52-54)gAc>gTc p.D18V NM_001146041.1 NP_001139513.1 Q9BYQ8 KRA49_HUMAN keratin associated protein 4-9 18 keratin filament p.D18V(1) central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3) 14 TGCGGCCAAGACCTCTGTCAG 0.627000 6 41 0 0 0.038147 0 0 LRPPRC 10128 broad.mit.edu 37 2 44153050 44153050 + Silent SNP T T C TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-11A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d fd15e363-f9b9-440d-8469-56377f9fa520 g.chr2:44153050T>C ENST00000260665.7 - 26 2844 c.2787A>G c.(2785-2787)agA>agG p.R929R NM_133259.3 NP_573566.2 P42704 LPPRC_HUMAN leucine-rich pentatricopeptide repeat containing 929 mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm beta-tubulin binding|microtubule binding|RNA binding p.R929R(1) breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2) 41 all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17) TTGCAACACATCTGTCACAAA 0.413000 6 85 0 0 0.021553 0 0 NOP58 51602 broad.mit.edu 37 2 203149110 203149110 + Nonsense_Mutation SNP G G T TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-11A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d fd15e363-f9b9-440d-8469-56377f9fa520 g.chr2:203149110G>T ENST00000264279.5 + 5 566 c.340G>T c.(340-342)Gaa>Taa p.E114* NOP58_ENST00000467734.1_3'UTR NM_015934.3 NP_057018.1 Q9Y2X3 NOP58_HUMAN NOP58 ribonucleoprotein 114 cell growth|rRNA processing|snRNP protein import into nucleus box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex protein binding|snoRNA binding p.E114*(1) breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(4)|prostate(2) 16 TGTTGTTAATGAACTTATGAG 0.373000 3 46 0.115264 0.130633 0.115264 1 0 FRG1B 0 broad.mit.edu 37 20 29625955 29625955 + Nonsense_Mutation SNP A A T TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-11A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d fd15e363-f9b9-440d-8469-56377f9fa520 g.chr20:29625955A>T ENST00000278882.3 + 5 579 c.199A>T c.(199-201)Aga>Tga p.R67* FRG1B_ENST00000439954.2_Nonsense_Mutation_p.R72*|FRG1B_ENST00000358464.4_Nonsense_Mutation_p.R67* endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9) 53 AATTGGACCAAGAGAACAATG 0.338000 6 88 0 0 0.029380 0 0 MUC5B 727897 broad.mit.edu 37 11 1266085 1266085 + Missense_Mutation SNP C C G TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-11A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d fd15e363-f9b9-440d-8469-56377f9fa520 g.chr11:1266085C>G ENST00000447027.1 + 31 8042 c.7984C>G c.(7984-7986)Ccc>Gcc p.P2662A RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.P2659A Q9HC84 MUC5B_HUMAN mucin 5B, oligomeric mucus/gel-forming 2659 11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich. Missing (in Ref. 6; AAB61398). cell adhesion extracellular region extracellular matrix structural constituent|protein binding p.P2638A(1) cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1) 137 all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229) BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1) CACCCACACCCCCACAGTGCT 0.617000 3 41 0 0 0.115264 0 0 RBM15 64783 broad.mit.edu 37 1 110884731 110884731 + Missense_Mutation SNP G G C TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-11A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d fd15e363-f9b9-440d-8469-56377f9fa520 g.chr1:110884731G>C ENST00000369784.3 + 1 3604 c.2704G>C c.(2704-2706)Ggg>Cgg p.G902R RBM15_ENST00000602849.1_Missense_Mutation_p.G902R|RBM15_ENST00000487146.2_Missense_Mutation_p.G902R NM_022768.4 NP_073605.4 Q96T37 RBM15_HUMAN RNA binding motif protein 15 902 SPOC. interspecies interaction between organisms nucleus nucleotide binding|protein binding|RNA binding p.G902R(1) ovary(3) 3 all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634) BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135) GCAGGCAGCCGGGGTGATCAG 0.552000 T MKL1 acute megakaryocytic leukemia 7 114 0 0 0.029380 0 0 FRG1B 0 broad.mit.edu 37 20 29625875 29625875 + Missense_Mutation SNP T T C rs143761036 by1000genomes TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-11A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d fd15e363-f9b9-440d-8469-56377f9fa520 g.chr20:29625875T>C ENST00000278882.3 + 5 499 c.119T>C c.(118-120)aTc>aCc p.I40T FRG1B_ENST00000439954.2_Missense_Mutation_p.I45T|FRG1B_ENST00000358464.4_Missense_Mutation_p.I40T p.I40T(4) endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9) 53 ATGTACAGAATCGCCCTGAAA 0.358000 8 96 0 0 0.058154 0 0 RP11-179A10.1 0 broad.mit.edu 37 11 11158570 11158570 + RNA DEL A A - rs10574607 TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-10A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d 993197fc-ba4c-466d-9cc2-e08c74cd8f45 g.chr11:11158570delA ENST00000525758.1 + 0 108 actctgtctcaaaaaaaaaaa 0.413 7 6 --- --- --- --- SDHAP1 0 broad.mit.edu 37 3 195711343 195711344 + RNA INS - - T TCGA-G9-6367-01A-11D-1786-08 TCGA-G9-6367-11A-01D-1786-08 Untested Somatic Phase_I WXS none Illumina GAIIx 7f76a7b4-1889-4550-a4d1-3c3a0d1a526d fd15e363-f9b9-440d-8469-56377f9fa520 g.chr3:195711343_195711344insT ENST00000427841.1 - 0 585 NR_003264.2 AAAGACTTCTCTGTGAGCTTTG 0.381 3 3 --- --- --- ---