Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPR32	2854	broad.mit.edu	37	19	51273918	51273918	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr19:51273918C>T	ENST00000270590.4	+	1	198	c.61C>T	c.(61-63)Cgt>Tgt	p.R21C		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	21						integral to plasma membrane	N-formyl peptide receptor activity	p.R21C(1)		breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GGTCCTGACACGTGATCGCTC	0.522000													15	44					0	0	1	0	0
BCL6	604	broad.mit.edu	37	3	187447543	187447543	+	Missense_Mutation	SNP	C	C	T	rs142220629		TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr3:187447543C>T	ENST00000406870.2	-	5	1016	c.650G>A	c.(649-651)cGg>cAg	p.R217Q	RP11-211G3.3_ENST00000449623.1_Intron|RP11-211G3.3_ENST00000437407.1_Intron|BCL6_ENST00000450123.2_Missense_Mutation_p.R217Q|BCL6_ENST00000232014.4_Missense_Mutation_p.R217Q	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	217					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R217Q(1)		central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		CACAGGCATCCGGACATCCCG	0.612000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								20	51					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79752812	79752812	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr5:79752812G>A	ENST00000338008.5	+	13	4024	c.3844G>A	c.(3844-3846)Gca>Aca	p.A1282T	ZFYVE16_ENST00000505560.1_Missense_Mutation_p.A1282T|ZFYVE16_ENST00000510158.1_Missense_Mutation_p.A1282T	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	1282					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity	p.A1282T(1)		breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TAGCATTGGAGCAAGTTTCAG	0.343000													21	42					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106558447	106558447	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr11:106558447G>A	ENST00000526355.1	-	8	2495	c.2027C>T	c.(2026-2028)cCg>cTg	p.P676L	GUCY1A2_ENST00000282249.2_Missense_Mutation_p.P707L|GUCY1A2_ENST00000347596.2_Missense_Mutation_p.P697L	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	676					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding	p.P676L(2)		breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		ACGAGACCGCGGAATGAATGT	0.418000													63	134					0	0	1	0	0
ACTBL2	345651	broad.mit.edu	37	5	56778328	56778328	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr5:56778328C>A	ENST00000423391.1	-	1	308	c.207G>T	c.(205-207)aaG>aaT	p.K69N	CTD-2023N9.1_ENST00000506106.1_RNA	NM_001017992.3	NP_001017992.1	Q562R1	ACTBL_HUMAN	actin, beta-like 2	69						cytoplasm|cytoskeleton	ATP binding	p.K69N(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(3)|pancreas(1)|prostate(2)	28		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		CGATAGGATACTTCAGGGTCA	0.547000													21	42					1.64293e-13	1.68401e-13	1	1	0
EML4	27436	broad.mit.edu	37	2	42543187	42543187	+	Missense_Mutation	SNP	A	A	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr2:42543187A>T	ENST00000318522.5	+	18	2315	c.2053A>T	c.(2053-2055)Ata>Tta	p.I685L	EML4_ENST00000402711.2_Missense_Mutation_p.I627L|EML4_ENST00000401738.3_Missense_Mutation_p.I696L|EML4_ENST00000453191.2_Intron	NM_019063.3	NP_061936.2	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	685					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding	p.I685L(1)	EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						GCGCTACTCAATAGGTAGGCA	0.423000			T	ALK	NSCLC								34	75					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100607821	100607821	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr7:100607821G>A	ENST00000319509.7	+	5	1968	c.1968G>A	c.(1966-1968)gaG>gaA	p.E656E	RP11-395B7.2_ENST00000434775.1_RNA|RP11-395B7.2_ENST00000420080.1_RNA					mucin 3A, cell surface associated									p.E656E(2)		breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						GCGAGTATGAGCAGGTGAAGA	0.637000													17	130					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987891	50987891	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr22:50987891G>A	ENST00000395676.2	+	1	1430	c.1296G>A	c.(1294-1296)gcG>gcA	p.A432A		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	432								p.A333A(1)		central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCCCACGCGCGCCACTCCCCG	0.672000													51	116					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								9	71					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118238971	118238971	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chrX:118238971C>A	ENST00000402510.2	-	7	1051	c.1052G>T	c.(1051-1053)aGt>aTt	p.S351I		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	351										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						CGCTGTCAAACTCTTATGTGG	0.418000													9	195					0.000673444	0.000673444	1	1	0
KIAA1467	57613	broad.mit.edu	37	12	13208628	13208628	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr12:13208628G>A	ENST00000197268.8	+	2	301	c.181G>A	c.(181-183)Gac>Aac	p.D61N		NM_020853.1	NP_065904.1	A2RU67	K1467_HUMAN	KIAA1467	61						integral to membrane		p.D61N(1)		NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(4)	36		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		GCCAGAACCCGACTCAGATGC	0.557000													47	86					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155206588	155206588	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr3:155206588G>A	ENST00000460012.1	-	20	2667	c.2310C>T	c.(2308-2310)aaC>aaT	p.N770N	PLCH1_ENST00000447496.2_Silent_p.N788N|PLCH1_ENST00000414191.1_Silent_p.N770N|PLCH1_ENST00000494598.1_Silent_p.N788N|PLCH1_ENST00000340059.7_Silent_p.N788N|PLCH1_ENST00000334686.6_Silent_p.N770N			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	788	C2.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity	p.N770N(1)		NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCCACACAGGGTTAAATCCTC	0.428000													22	46					0	0	1	0	0
HPGD	3248	broad.mit.edu	37	4	175416699	175416699	+	Splice_Site	SNP	C	C	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr4:175416699C>A	ENST00000296522.6	-	5	944	c.498_splice	c.e5+1	p.A166_splice	HPGD_ENST00000510901.1_Splice_Site_p.A45_splice|HPGD_ENST00000542498.1_Intron|HPGD_ENST00000422112.2_Splice_Site_p.A98_splice|HPGD_ENST00000296521.7_Splice_Site_p.A166_splice|HPGD_ENST00000541923.1_Splice_Site_p.A45_splice	NM_000860.5|NM_001145816.2|NM_001256301.1|NM_001256307.1	NP_000851.2|NP_001139288.1|NP_001243230.1|NP_001243236.1	P15428	PGDH_HUMAN	hydroxyprostaglandin dehydrogenase 15-(NAD)	166					female pregnancy|lipoxygenase pathway|negative regulation of cell cycle|parturition|prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|NAD+ binding|prostaglandin E receptor activity|protein homodimerization activity	p.A166A(1)		kidney(1)|lung(3)|prostate(3)	7		Prostate(90;0.00763)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;2.6e-18)|Epithelial(43;4.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.23e-09)|GBM - Glioblastoma multiforme(59;0.00176)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.0253)	NADH(DB00157)	GTAGCCTCACCGCTGCTGAGC	0.408000													39	51					9.39024e-22	1.01316e-21	1	1	0
SSH1	54434	broad.mit.edu	37	12	109192926	109192926	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr12:109192926G>A	ENST00000326495.5	-	13	1292	c.1199C>T	c.(1198-1200)tCg>tTg	p.S400L	SSH1_ENST00000326470.5_Missense_Mutation_p.S411L|SSH1_ENST00000551165.1_Missense_Mutation_p.S400L|SSH1_ENST00000360239.3_Missense_Mutation_p.S88L	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	400	Tyrosine-protein phosphatase.				actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGTGGAGGCCGAGCGACTCAC	0.557000													6	37					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11047499	11047499	+	RNA	SNP	G	G	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr21:11047499G>T	ENST00000470054.1	-	0	755									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCCAGCCGTTGGTTGGTACAG	0.343000													42	572					3.76604e-16	3.95917e-16	1	1	0
SCN5A	6331	broad.mit.edu	37	3	38627292	38627292	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr3:38627292G>A	ENST00000413689.1	-	16	2870	c.2677C>T	c.(2677-2679)Cgc>Tgc	p.R893C	SCN5A_ENST00000425664.1_Missense_Mutation_p.R893C|SCN5A_ENST00000423572.2_Missense_Mutation_p.R893C|SCN5A_ENST00000414099.2_Missense_Mutation_p.R893C|SCN5A_ENST00000333535.4_Missense_Mutation_p.R893C|SCN5A_ENST00000443581.1_Missense_Mutation_p.R893C|SCN5A_ENST00000455624.2_Missense_Mutation_p.R893C|SCN5A_ENST00000451551.2_Missense_Mutation_p.R893C|SCN5A_ENST00000450102.2_Missense_Mutation_p.R893C|SCN5A_ENST00000449557.2_Missense_Mutation_p.R893C	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	893					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity	p.R893C(2)		NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CAGAGGATGCGGAAGATGATG	0.547000													9	221					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116446812	116446812	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr12:116446812G>A	ENST00000281928.3	-	10	1612	c.1406C>T	c.(1405-1407)aCa>aTa	p.T469I		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	469					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent			p.T469I(1)		NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TCTTTCTGCTGTTTTGTGCTT	0.478000													101	145					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871052	170871052	+	Silent	SNP	G	G	A	rs112083427		TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr6:170871052G>A	ENST00000392092.2	+	3	507	c.228G>A	c.(226-228)caG>caA	p.Q76Q	TBP_ENST00000230354.6_Silent_p.Q76Q|TBP_ENST00000540980.1_Silent_p.Q56Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	76	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q76Q(4)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacagcagcagcagcagc	0.572000													4	64					0	0	1	0	0
ASB1	51665	broad.mit.edu	37	2	239344476	239344476	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr2:239344476C>G	ENST00000264607.4	+	3	563	c.316C>G	c.(316-318)Ctg>Gtg	p.L106V	ASB1_ENST00000469885.1_3'UTR|ASB1_ENST00000409297.1_Intron	NM_001040445.1	NP_001035535.1	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box containing 1	106					intracellular signal transduction|negative regulation of cytokine biosynthetic process					breast(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		CGAGGTGGATCTGGTGGACGT	0.632000													6	104					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139662012	139662012	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr8:139662012T>C	ENST00000303045.6	-	46	3789	c.3343A>G	c.(3343-3345)Aat>Gat	p.N1115D	COL22A1_ENST00000435777.1_Missense_Mutation_p.N1095D|COL22A1_ENST00000341807.4_5'UTR	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1115	Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity	p.N1115D(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGGCAGTCATTGCACACATCC	0.532000										HNSCC(7;0.00092)			27	31					0	0	1	0	0
GSTT1	2952	broad.mit.edu	37	22	24384213	24384213	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr22:24384213G>A	ENST00000248935.5	-	1	71	c.19C>T	c.(19-21)Ctg>Ttg	p.L7L	GSTT1_ENST00000439996.2_5'UTR	NM_000853.2	NP_000844.2	P30711	GSTT1_HUMAN	glutathione S-transferase theta 1	7	GST N-terminal.				glutathione metabolic process	cytosol|soluble fraction	glutathione peroxidase activity|glutathione transferase activity	p.L7L(1)		cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|ovary(1)|prostate(1)|skin(1)	6					Glutathione(DB00143)	AGCAGGTCCAGGTACAGCTCC	0.587000									Myelodysplasia and Acute Myeloid Leukemia (AML), Familial				58	81					0	0	1	0	0
NAF1	92345	broad.mit.edu	37	4	164050124	164050124	+	Silent	SNP	T	T	G			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr4:164050124T>G	ENST00000274054.2	-	8	1603	c.1410A>C	c.(1408-1410)ccA>ccC	p.P470P	NAF1_ENST00000509434.1_Intron|NAF1_ENST00000422287.2_Intron	NM_138386.2	NP_612395.2	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 ribonucleoprotein	470	Pro-rich.				rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(10)|ovary(2)	21	all_hematologic(180;0.166)	Prostate(90;0.109)				ggggagggggtgggggtaggg	0.522000													3	3					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160287661	160287661	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr2:160287661T>C	ENST00000392783.2	-	10	2402	c.1907A>G	c.(1906-1908)gAt>gGt	p.D636G	BAZ2B_ENST00000392782.1_Missense_Mutation_p.D634G|BAZ2B_ENST00000355831.2_Missense_Mutation_p.D636G|BAZ2B_ENST00000343439.5_Intron	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	636	Asp/Glu-rich (acidic).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.D636G(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						TGAATTACTATCTGATTCTGG	0.343000													16	34					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141680622	141680622	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr2:141680622T>G	ENST00000389484.3	-	21	4202	c.3231A>C	c.(3229-3231)aaA>aaC	p.K1077N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1077	LDL-receptor class A 8.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.K1077N(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTCACAGTCTTTTTCTCCAT	0.418000										TSP Lung(27;0.18)			47	113					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183077436	183077436	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr1:183077436G>A	ENST00000258341.4	+	3	1006	c.749G>A	c.(748-750)aGa>aAa	p.R250K		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	250	Laminin N-terminal.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent	p.R250K(2)		NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTGACATCAGAGTAACTCTT	0.378000													15	106					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56417898	56417898	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr6:56417898C>T	ENST00000370754.5	-	61	15598	c.15599G>A	c.(15598-15600)aGc>aAc	p.S5200N	DST_ENST00000421834.2_Missense_Mutation_p.S2934N|DST_ENST00000370788.2_Missense_Mutation_p.S2934N|DST_ENST00000361203.3_Missense_Mutation_p.S5020N|DST_ENST00000370769.4_Missense_Mutation_p.S5022N|DST_ENST00000312431.6_3'UTR|DST_ENST00000446842.2_Missense_Mutation_p.S4696N|DST_ENST00000244364.6_Missense_Mutation_p.S2608N			Q03001	DYST_HUMAN	dystonin	5020					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity	p.S2608N(1)|p.S5022N(1)		NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ACTGAGCAAGCTATTGGCTGT	0.413000													98	183					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36691752	36691752	+	Silent	SNP	C	C	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr2:36691752C>T	ENST00000280527.2	+	5	1312	c.945C>T	c.(943-945)ggC>ggT	p.G315G		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	315					nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity	p.G315G(1)		autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				TCTCTCGTGGCGATGGGACAC	0.502000													64	239					0	0	1	0	0
DSTYK	25778	broad.mit.edu	37	1	205126469	205126469	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr1:205126469C>T	ENST00000367162.3	-	10	2314	c.2284G>A	c.(2284-2286)Gtg>Atg	p.V762M	DSTYK_ENST00000367161.3_Missense_Mutation_p.V762M|DSTYK_ENST00000367160.4_Intron	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase	762	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.V223M(1)|p.V762M(1)		breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						ATTCCCTCCACCACATCTAGT	0.473000													42	96					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115612543	115612543	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr10:115612543T>C	ENST00000361384.2	-	1	1316	c.399A>G	c.(397-399)atA>atG	p.I133M	DCLRE1A_ENST00000369305.1_Missense_Mutation_p.I133M	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	133	Nuclear localization region.				cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		GTGTCTGCCCTATCAATGAGG	0.413000								Other identified genes with known or suspected DNA repair function					12	128					0	0	1	0	0
HOOK3	84376	broad.mit.edu	37	8	42852766	42852766	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr8:42852766T>C	ENST00000307602.4	+	16	1806	c.1606T>C	c.(1606-1608)Tca>Cca	p.S536P		NM_032410.3	NP_115786.1	Q86VS8	HOOK3_HUMAN	hook microtubule-tethering protein 3	536					cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding	p.S536P(1)		NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	31	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			GGATCAAGGCTCAAAAGCAGA	0.308000			T	RET	papillary thyroid								15	59					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200878355	200878355	+	Silent	SNP	C	C	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr1:200878355C>T	ENST00000367342.4	+	8	1244	c.1044C>T	c.(1042-1044)agC>agT	p.S348S	C1orf106_ENST00000413687.2_Silent_p.S263S	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	348	Pro-rich.									endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						TTTGCAGCAGCCCAGCCACCA	0.602000													34	89					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72131722	72131722	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr9:72131722G>A	ENST00000265381.4	-	2	627	c.405C>T	c.(403-405)gcC>gcT	p.A135A		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	135					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle		p.A135A(1)		endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						CGGCGTGCTCGGCCTCTGCCT	0.692000													24	54					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													8	88					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114270000	114270000	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr7:114270000G>A	ENST00000393500.3	+	11	1132	c.312G>A	c.(310-312)caG>caA	p.Q104Q	FOXP2_ENST00000360232.4_Silent_p.Q179Q|FOXP2_ENST00000393498.2_Silent_p.Q159Q|FOXP2_ENST00000393489.3_Silent_p.Q87Q|FOXP2_ENST00000408937.3_Silent_p.Q204Q|FOXP2_ENST00000393494.2_Silent_p.Q179Q|FOXP2_ENST00000393491.3_Silent_p.Q87Q|FOXP2_ENST00000403559.4_Silent_p.Q196Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000378237.3_Silent_p.Q179Q|FOXP2_ENST00000350908.4_Silent_p.Q179Q|FOXP2_ENST00000390668.3_Silent_p.Q203Q			O15409	FOXP2_HUMAN	forkhead box P2	179	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q204Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						agcaacaacagcagcagcagc	0.498000													6	96					0	0	1	0	0
PRMT8	56341	broad.mit.edu	37	12	3649787	3649787	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr12:3649787T>C	ENST00000382622.3	+	2	481	c.91T>C	c.(91-93)Tcc>Ccc	p.S31P	PRMT8_ENST00000261252.4_3'UTR|PRMT8_ENST00000452611.2_Missense_Mutation_p.S22P	NM_019854.4	NP_062828.3	Q9NR22	ANM8_HUMAN	protein arginine methyltransferase 8	31					regulation of protein binding	cytoplasm|plasma membrane	histone-arginine N-methyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(31;0.0109)|COAD - Colon adenocarcinoma(12;0.0264)			CAGCCCCCCCTCCCAGCCCCC	0.652000													14	107					0	0	1	0	0
GPR32	2854	broad.mit.edu	37	19	51273918	51273918	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr19:51273918C>T	ENST00000270590.4	+	1	198	c.61C>T	c.(61-63)Cgt>Tgt	p.R21C		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	21						integral to plasma membrane	N-formyl peptide receptor activity	p.R21C(1)		breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GGTCCTGACACGTGATCGCTC	0.522000													15	44					0	0	1	0	0
BCL6	604	broad.mit.edu	37	3	187447543	187447543	+	Missense_Mutation	SNP	C	C	T	rs142220629		TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr3:187447543C>T	ENST00000406870.2	-	5	1016	c.650G>A	c.(649-651)cGg>cAg	p.R217Q	BCL6_ENST00000232014.4_Missense_Mutation_p.R217Q|RP11-211G3.3_ENST00000449623.1_Intron|BCL6_ENST00000450123.2_Missense_Mutation_p.R217Q|RP11-211G3.3_ENST00000437407.1_Intron	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	217					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R217Q(1)		central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		CACAGGCATCCGGACATCCCG	0.612000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								20	51					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79752812	79752812	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr5:79752812G>A	ENST00000338008.5	+	13	4024	c.3844G>A	c.(3844-3846)Gca>Aca	p.A1282T	ZFYVE16_ENST00000510158.1_Missense_Mutation_p.A1282T|ZFYVE16_ENST00000505560.1_Missense_Mutation_p.A1282T	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	1282					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity	p.A1282T(1)		breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		TAGCATTGGAGCAAGTTTCAG	0.343000													21	42					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106558447	106558447	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr11:106558447G>A	ENST00000526355.1	-	8	2495	c.2027C>T	c.(2026-2028)cCg>cTg	p.P676L	GUCY1A2_ENST00000282249.2_Missense_Mutation_p.P707L|GUCY1A2_ENST00000347596.2_Missense_Mutation_p.P697L	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	676					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding	p.P676L(2)		breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		ACGAGACCGCGGAATGAATGT	0.418000													63	134					0	0	1	0	0
ACTBL2	345651	broad.mit.edu	37	5	56778328	56778328	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr5:56778328C>A	ENST00000423391.1	-	1	308	c.207G>T	c.(205-207)aaG>aaT	p.K69N	CTD-2023N9.1_ENST00000506106.1_RNA	NM_001017992.3	NP_001017992.1	Q562R1	ACTBL_HUMAN	actin, beta-like 2	69						cytoplasm|cytoskeleton	ATP binding	p.K69N(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(3)|pancreas(1)|prostate(2)	28		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		CGATAGGATACTTCAGGGTCA	0.547000													21	42					1.64293e-13	1.67227e-13	1	1	0
EML4	27436	broad.mit.edu	37	2	42543187	42543187	+	Missense_Mutation	SNP	A	A	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr2:42543187A>T	ENST00000318522.5	+	18	2315	c.2053A>T	c.(2053-2055)Ata>Tta	p.I685L	EML4_ENST00000453191.2_Intron|EML4_ENST00000402711.2_Missense_Mutation_p.I627L|EML4_ENST00000401738.3_Missense_Mutation_p.I696L	NM_019063.3	NP_061936.2	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	685					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding	p.I685L(1)	EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						GCGCTACTCAATAGGTAGGCA	0.423000			T	ALK	NSCLC								34	75					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100607821	100607821	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr7:100607821G>A	ENST00000319509.7	+	5	1968	c.1968G>A	c.(1966-1968)gaG>gaA	p.E656E	RP11-395B7.2_ENST00000434775.1_RNA|RP11-395B7.2_ENST00000420080.1_RNA					mucin 3A, cell surface associated									p.E656E(2)		breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						GCGAGTATGAGCAGGTGAAGA	0.637000													17	130					0	0	1	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987891	50987891	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr22:50987891G>A	ENST00000395676.2	+	1	1430	c.1296G>A	c.(1294-1296)gcG>gcA	p.A432A		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	432								p.A333A(1)		central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCCCACGCGCGCCACTCCCCG	0.672000													51	116					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								9	71					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118238971	118238971	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chrX:118238971C>A	ENST00000402510.2	-	7	1051	c.1052G>T	c.(1051-1053)aGt>aTt	p.S351I		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	351										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						CGCTGTCAAACTCTTATGTGG	0.418000													9	195					0.000673444	0.000673444	1	1	0
KIAA1467	57613	broad.mit.edu	37	12	13208628	13208628	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr12:13208628G>A	ENST00000197268.8	+	2	301	c.181G>A	c.(181-183)Gac>Aac	p.D61N		NM_020853.1	NP_065904.1	A2RU67	K1467_HUMAN	KIAA1467	61						integral to membrane		p.D61N(1)		NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(4)	36		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		GCCAGAACCCGACTCAGATGC	0.557000													47	86					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155206588	155206588	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr3:155206588G>A	ENST00000460012.1	-	20	2667	c.2310C>T	c.(2308-2310)aaC>aaT	p.N770N	PLCH1_ENST00000414191.1_Silent_p.N770N|PLCH1_ENST00000334686.6_Silent_p.N770N|PLCH1_ENST00000447496.2_Silent_p.N788N|PLCH1_ENST00000340059.7_Silent_p.N788N|PLCH1_ENST00000494598.1_Silent_p.N788N			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	788	C2.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity	p.N770N(1)		NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCCACACAGGGTTAAATCCTC	0.428000													22	46					0	0	1	0	0
HPGD	3248	broad.mit.edu	37	4	175416699	175416699	+	Splice_Site	SNP	C	C	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr4:175416699C>A	ENST00000296522.6	-	5	944	c.498_splice	c.e5+1	p.A166_splice	HPGD_ENST00000541923.1_Splice_Site_p.A45_splice|HPGD_ENST00000542498.1_Intron|HPGD_ENST00000296521.7_Splice_Site_p.A166_splice|HPGD_ENST00000510901.1_Splice_Site_p.A45_splice|HPGD_ENST00000422112.2_Splice_Site_p.A98_splice	NM_000860.5|NM_001145816.2|NM_001256301.1|NM_001256307.1	NP_000851.2|NP_001139288.1|NP_001243230.1|NP_001243236.1	P15428	PGDH_HUMAN	hydroxyprostaglandin dehydrogenase 15-(NAD)	166					female pregnancy|lipoxygenase pathway|negative regulation of cell cycle|parturition|prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|NAD+ binding|prostaglandin E receptor activity|protein homodimerization activity	p.A166A(1)		kidney(1)|lung(3)|prostate(3)	7		Prostate(90;0.00763)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;2.6e-18)|Epithelial(43;4.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.23e-09)|GBM - Glioblastoma multiforme(59;0.00176)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.0253)	NADH(DB00157)	GTAGCCTCACCGCTGCTGAGC	0.408000													39	51					9.39024e-22	9.91192e-22	1	1	0
SSH1	54434	broad.mit.edu	37	12	109192926	109192926	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr12:109192926G>A	ENST00000326495.5	-	13	1292	c.1199C>T	c.(1198-1200)tCg>tTg	p.S400L	SSH1_ENST00000551165.1_Missense_Mutation_p.S400L|SSH1_ENST00000360239.3_Missense_Mutation_p.S88L|SSH1_ENST00000326470.5_Missense_Mutation_p.S411L	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	400	Tyrosine-protein phosphatase.				actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGTGGAGGCCGAGCGACTCAC	0.557000													6	37					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11047499	11047499	+	RNA	SNP	G	G	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr21:11047499G>T	ENST00000470054.1	-	0	755									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCCAGCCGTTGGTTGGTACAG	0.343000													42	572					3.76604e-16	3.90298e-16	1	1	0
SCN5A	6331	broad.mit.edu	37	3	38627292	38627292	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr3:38627292G>A	ENST00000413689.1	-	16	2870	c.2677C>T	c.(2677-2679)Cgc>Tgc	p.R893C	SCN5A_ENST00000414099.2_Missense_Mutation_p.R893C|SCN5A_ENST00000423572.2_Missense_Mutation_p.R893C|SCN5A_ENST00000449557.2_Missense_Mutation_p.R893C|SCN5A_ENST00000451551.2_Missense_Mutation_p.R893C|SCN5A_ENST00000450102.2_Missense_Mutation_p.R893C|SCN5A_ENST00000443581.1_Missense_Mutation_p.R893C|SCN5A_ENST00000425664.1_Missense_Mutation_p.R893C|SCN5A_ENST00000333535.4_Missense_Mutation_p.R893C|SCN5A_ENST00000455624.2_Missense_Mutation_p.R893C	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	893					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity	p.R893C(2)		NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CAGAGGATGCGGAAGATGATG	0.547000													9	221					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116446812	116446812	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr12:116446812G>A	ENST00000281928.3	-	10	1612	c.1406C>T	c.(1405-1407)aCa>aTa	p.T469I		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	469					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent			p.T469I(1)		NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TCTTTCTGCTGTTTTGTGCTT	0.478000													101	145					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871052	170871052	+	Silent	SNP	G	G	A	rs112083427		TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr6:170871052G>A	ENST00000392092.2	+	3	507	c.228G>A	c.(226-228)caG>caA	p.Q76Q	TBP_ENST00000230354.6_Silent_p.Q76Q|TBP_ENST00000540980.1_Silent_p.Q56Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	76	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q76Q(4)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacagcagcagcagcagc	0.572000													4	64					0	0	1	0	0
ASB1	51665	broad.mit.edu	37	2	239344476	239344476	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr2:239344476C>G	ENST00000264607.4	+	3	563	c.316C>G	c.(316-318)Ctg>Gtg	p.L106V	ASB1_ENST00000469885.1_3'UTR|ASB1_ENST00000409297.1_Intron	NM_001040445.1	NP_001035535.1	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box containing 1	106					intracellular signal transduction|negative regulation of cytokine biosynthetic process					breast(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		CGAGGTGGATCTGGTGGACGT	0.632000													6	104					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38645343	38645343	+	RNA	SNP	C	C	T	rs75687299	by1000genomes	TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr10:38645343C>T	ENST00000494540.1	+	0	36					NR_003086.1																						AAAGCAGCGGCGGCGTTTGCT	0.597000													7	30					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139662012	139662012	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr8:139662012T>C	ENST00000303045.6	-	46	3789	c.3343A>G	c.(3343-3345)Aat>Gat	p.N1115D	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Missense_Mutation_p.N1095D	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1115	Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity	p.N1115D(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGGCAGTCATTGCACACATCC	0.532000										HNSCC(7;0.00092)			27	31					0	0	1	0	0
GSTT1	2952	broad.mit.edu	37	22	24384213	24384213	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr22:24384213G>A	ENST00000248935.5	-	1	71	c.19C>T	c.(19-21)Ctg>Ttg	p.L7L	GSTT1_ENST00000439996.2_5'UTR	NM_000853.2	NP_000844.2	P30711	GSTT1_HUMAN	glutathione S-transferase theta 1	7	GST N-terminal.				glutathione metabolic process	cytosol|soluble fraction	glutathione peroxidase activity|glutathione transferase activity	p.L7L(1)		cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|ovary(1)|prostate(1)|skin(1)	6					Glutathione(DB00143)	AGCAGGTCCAGGTACAGCTCC	0.587000									Myelodysplasia and Acute Myeloid Leukemia (AML), Familial				58	81					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16959698	16959698	+	RNA	SNP	G	G	A	rs9730434	by1000genomes	TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr1:16959698G>A	ENST00000412962.1	-	0	74																		p.H56H(4)									GGTCCTTCTCGTGGAGCACCT	0.657000													15	124					0	0	1	0	0
NAF1	92345	broad.mit.edu	37	4	164050124	164050124	+	Silent	SNP	T	T	G			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr4:164050124T>G	ENST00000274054.2	-	8	1603	c.1410A>C	c.(1408-1410)ccA>ccC	p.P470P	NAF1_ENST00000422287.2_Intron|NAF1_ENST00000509434.1_Intron	NM_138386.2	NP_612395.2	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 ribonucleoprotein	470	Pro-rich.				rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(10)|ovary(2)	21	all_hematologic(180;0.166)	Prostate(90;0.109)				ggggagggggtgggggtaggg	0.522000													3	3					0	0	1	0	0
BAZ2B	29994	broad.mit.edu	37	2	160287661	160287661	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr2:160287661T>C	ENST00000392783.2	-	10	2402	c.1907A>G	c.(1906-1908)gAt>gGt	p.D636G	BAZ2B_ENST00000392782.1_Missense_Mutation_p.D634G|BAZ2B_ENST00000355831.2_Missense_Mutation_p.D636G|BAZ2B_ENST00000343439.5_Intron	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	636	Asp/Glu-rich (acidic).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.D636G(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						TGAATTACTATCTGATTCTGG	0.343000													16	34					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141680622	141680622	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr2:141680622T>G	ENST00000389484.3	-	21	4202	c.3231A>C	c.(3229-3231)aaA>aaC	p.K1077N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1077	LDL-receptor class A 8.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.K1077N(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTCACAGTCTTTTTCTCCAT	0.418000										TSP Lung(27;0.18)			47	113					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183077436	183077436	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr1:183077436G>A	ENST00000258341.4	+	3	1006	c.749G>A	c.(748-750)aGa>aAa	p.R250K		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	250	Laminin N-terminal.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent	p.R250K(2)		NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTGACATCAGAGTAACTCTT	0.378000													15	106					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56417898	56417898	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr6:56417898C>T	ENST00000370754.5	-	61	15598	c.15599G>A	c.(15598-15600)aGc>aAc	p.S5200N	DST_ENST00000421834.2_Missense_Mutation_p.S2934N|DST_ENST00000370769.4_Missense_Mutation_p.S5022N|DST_ENST00000370788.2_Missense_Mutation_p.S2934N|DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Missense_Mutation_p.S2608N|DST_ENST00000361203.3_Missense_Mutation_p.S5020N|DST_ENST00000446842.2_Missense_Mutation_p.S4696N			Q03001	DYST_HUMAN	dystonin	5020					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity	p.S2608N(1)|p.S5022N(1)		NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			ACTGAGCAAGCTATTGGCTGT	0.413000													98	183					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36691752	36691752	+	Silent	SNP	C	C	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr2:36691752C>T	ENST00000280527.2	+	5	1312	c.945C>T	c.(943-945)ggC>ggT	p.G315G		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	315					nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity	p.G315G(1)		autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				TCTCTCGTGGCGATGGGACAC	0.502000													64	239					0	0	1	0	0
DSTYK	25778	broad.mit.edu	37	1	205126469	205126469	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr1:205126469C>T	ENST00000367162.3	-	10	2314	c.2284G>A	c.(2284-2286)Gtg>Atg	p.V762M	DSTYK_ENST00000367160.4_Intron|DSTYK_ENST00000367161.3_Missense_Mutation_p.V762M	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase	762	Protein kinase.					cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.V223M(1)|p.V762M(1)		breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						ATTCCCTCCACCACATCTAGT	0.473000													42	96					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115612543	115612543	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr10:115612543T>C	ENST00000361384.2	-	1	1316	c.399A>G	c.(397-399)atA>atG	p.I133M	DCLRE1A_ENST00000369305.1_Missense_Mutation_p.I133M	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	133	Nuclear localization region.				cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		GTGTCTGCCCTATCAATGAGG	0.413000								Other identified genes with known or suspected DNA repair function					12	128					0	0	1	0	0
HOOK3	84376	broad.mit.edu	37	8	42852766	42852766	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr8:42852766T>C	ENST00000307602.4	+	16	1806	c.1606T>C	c.(1606-1608)Tca>Cca	p.S536P		NM_032410.3	NP_115786.1	Q86VS8	HOOK3_HUMAN	hook microtubule-tethering protein 3	536					cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding	p.S536P(1)		NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	31	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			GGATCAAGGCTCAAAAGCAGA	0.308000			T	RET	papillary thyroid								15	59					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292820	102292820	+	RNA	SNP	G	G	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr15:102292820G>C	ENST00000561463.1	+	0	866																		p.T136T(2)									GCGTGGGAACGAGAAGACACT	0.592000													3	25					0	0	1	0	0
C1orf106	55765	broad.mit.edu	37	1	200878355	200878355	+	Silent	SNP	C	C	T			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr1:200878355C>T	ENST00000367342.4	+	8	1244	c.1044C>T	c.(1042-1044)agC>agT	p.S348S	C1orf106_ENST00000413687.2_Silent_p.S263S	NM_018265.3	NP_060735.3	Q3KP66	CA106_HUMAN	chromosome 1 open reading frame 106	348	Pro-rich.									endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(2)	21						TTTGCAGCAGCCCAGCCACCA	0.602000													34	89					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72131722	72131722	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr9:72131722G>A	ENST00000265381.4	-	2	627	c.405C>T	c.(403-405)gcC>gcT	p.A135A		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	135					axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle		p.A135A(1)		endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						CGGCGTGCTCGGCCTCTGCCT	0.692000													24	54					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													8	88					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114270000	114270000	+	Silent	SNP	G	G	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr7:114270000G>A	ENST00000393500.3	+	11	1132	c.312G>A	c.(310-312)caG>caA	p.Q104Q	FOXP2_ENST00000393489.3_Silent_p.Q87Q|FOXP2_ENST00000393491.3_Silent_p.Q87Q|FOXP2_ENST00000403559.4_Silent_p.Q196Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000393498.2_Silent_p.Q159Q|FOXP2_ENST00000350908.4_Silent_p.Q179Q|FOXP2_ENST00000390668.3_Silent_p.Q203Q|FOXP2_ENST00000408937.3_Silent_p.Q204Q|FOXP2_ENST00000378237.3_Silent_p.Q179Q|FOXP2_ENST00000360232.4_Silent_p.Q179Q|FOXP2_ENST00000393494.2_Silent_p.Q179Q			O15409	FOXP2_HUMAN	forkhead box P2	179	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q204Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						agcaacaacagcagcagcagc	0.498000													6	96					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154842199	154842200	+	In_Frame_Ins	INS	-	-	GCTGCT	rs58327065		TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr1:154842199_154842200insGCTGCT	ENST00000271915.3	-	1	556_557	c.241_242insAGCAGC	c.(241-243)acc>AGCAGCacc	p.80_81insSS		NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	80	Poly-Gln.					integral to membrane	calmodulin binding	p.Q80_P81insQQ(2)		cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			GGGATGCGGTGgctgctgctgc	0.698													7	8	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217650443	217650443	+	RNA	DEL	T	T	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr2:217650443delT	ENST00000447289.1	+	0	510																											cccggcTCACTTTTTTTTTTT	0.433													3	3	---	---	---	---					
FIP1L1	81608	broad.mit.edu	37	4	54319248	54319249	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr4:54319248_54319249delAG	ENST00000337488.6	+	16	1641_1642	c.1447_1448delAG	c.(1447-1449)afs	p.R483fs	FIP1L1_ENST00000306932.6_Frame_Shift_Del_p.R409fs|FIP1L1_ENST00000358575.5_Frame_Shift_Del_p.R477fs|FIP1L1_ENST00000507166.1_Intron	NM_030917.3	NP_112179.2	Q6UN15	FIP1_HUMAN	factor interacting with PAPOLA and CPSF1	483	Arg-rich.|Glu-rich.|Sufficient for interaction with CPSF1 and CSTF3.				mRNA processing	nucleus	RNA binding	p.R487fs*3(2)		large_intestine(3)|liver(1)|ovary(1)|skin(1)	6			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			agaACGCACCAGAGAGAGAGAG	0.470			T	PDGFRA	idiopathic hypereosinophilic syndrome								9	128	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134073569	134073571	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr4:134073569_134073571delCTG	ENST00000264360.4	+	1	3100_3102	c.2274_2276delCTG	c.(2272-2277)ctc>ct	p.LC758del		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	758	Cys-rich.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTGCTGCCTCTGCTGCTGCTGC	0.581													7	86	---	---	---	---					
STK19	8859	broad.mit.edu	37	6	31939825	31939826	+	Frame_Shift_Ins	INS	-	-	G			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr6:31939825_31939826insG	ENST00000375331.2	+	1	218_219	c.52_53insG	c.(52-54)ggcfs	p.G18fs	DOM3Z_ENST00000375349.3_5'UTR|DOM3Z_ENST00000337523.5_5'UTR|DOM3Z_ENST00000478221.1_5'UTR|STK19_ENST00000375333.2_Frame_Shift_Ins_p.G18fs	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	18						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						GCGACAGTGGCGGGCAAACCCC	0.634													8	315	---	---	---	---					
STK19	8859	broad.mit.edu	37	6	31939829	31939830	+	Frame_Shift_Ins	INS	-	-	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr6:31939829_31939830insA	ENST00000375331.2	+	1	222_223	c.56_57insA	c.(55-57)gaafs	p.E19fs	DOM3Z_ENST00000375349.3_5'UTR|DOM3Z_ENST00000337523.5_5'UTR|DOM3Z_ENST00000478221.1_5'UTR|STK19_ENST00000375333.2_Frame_Shift_Ins_p.E19fs	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	19						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						CAGTGGCGGGCAAACCCCTCCC	0.634													7	250	---	---	---	---					
DST	667	broad.mit.edu	37	6	56510689	56510690	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr6:56510689_56510690delTC	ENST00000370754.5	-	14	1652_1653	c.1653_1654delGA	c.(1651-1656)gaagfs	p.EK551fs	DST_ENST00000370769.4_Frame_Shift_Del_p.EK373fs|DST_ENST00000421834.2_Frame_Shift_Del_p.EK373fs|DST_ENST00000312431.6_Frame_Shift_Del_p.EK373fs|DST_ENST00000370788.2_Frame_Shift_Del_p.EK373fs|DST_ENST00000361203.3_Frame_Shift_Del_p.EK373fs			Q03001	DYST_HUMAN	dystonin	373					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CGAAGGGCCTTCTCTCTCTCTA	0.441													7	271	---	---	---	---					
LMTK2	22853	broad.mit.edu	37	7	97820131	97820132	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr7:97820131_97820132delAG	ENST00000297293.5	+	10	1383_1384	c.1090_1091delAG	c.(1090-1092)afs	p.R364fs		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	364	Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CCAAGTCATTAGAGAGAGAGAC	0.495													7	672	---	---	---	---					
KMT2C	58508	broad.mit.edu	37	7	151904428	151904429	+	Frame_Shift_Ins	INS	-	-	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr7:151904428_151904429insA	ENST00000355193.2	-	24	4015_4016	c.3797_3798insT	c.(3796-3798)gacfs	p.D1266fs	KMT2C_ENST00000262189.6_Frame_Shift_Ins_p.D1266fs					lysine (K)-specific methyltransferase 2C																		CACCATCTGTTCCTTCCACTCC	0.381													43	102	---	---	---	---					
CHD7	55636	broad.mit.edu	37	8	61693942	61693943	+	In_Frame_Ins	INS	-	-	AAAGCA			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr8:61693942_61693943insAAAGCA	ENST00000423902.2	+	3	2528_2529	c.2049_2050insAAAGCA	c.(2047-2052)aaaagc>aaAAAGCAaagc	p.683_684KS>KKQS	CHD7_ENST00000525508.1_In_Frame_Ins_p.683_684KS>KKQS|CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	683	Lys-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity	p.556_871dup(1)		NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CAAAGGAAAAGAAAGCAAAAAC	0.450													7	42	---	---	---	---					
SLC10A5	347051	broad.mit.edu	37	8	82606545	82606546	+	Frame_Shift_Ins	INS	-	-	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr8:82606545_82606546insC	ENST00000518568.1	-	1	1863_1864	c.662_663insG	c.(661-663)gtafs	p.V221fs		NM_001010893.2	NP_001010893.1	Q5PT55	NTCP5_HUMAN	solute carrier family 10, member 5	221						integral to membrane	bile acid:sodium symporter activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)	15						CAAAGAGATAGCCCCCACCCCC	0.470													7	522	---	---	---	---					
TTLL11	158135	broad.mit.edu	37	9	124855330	124855331	+	In_Frame_Ins	INS	-	-	TGGCCT	rs3833704		TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr9:124855330_124855331insTGGCCT	ENST00000321582.5	-	1	554_555	c.367_368insAGGCCA	c.(367-369)agc>AGGCCAagc	p.122_123insRP	TTLL11_ENST00000373776.3_In_Frame_Ins_p.122_123insRP|TTLL11_ENST00000474723.1_5'UTR	NM_001139442.1	NP_001132914.1	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	122					protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(3)|skin(1)	18						cgtctccgctgtggcctcggcc	0.762													4	4	---	---	---	---					
DDX6	1656	broad.mit.edu	37	11	118629613	118629614	+	Splice_Site	INS	-	-	G			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr11:118629613_118629614insG	ENST00000264018.4	-	9	1170		c.e9-2		DDX6_ENST00000526070.2_Splice_Site|DDX6_ENST00000534980.1_Splice_Site	NM_004397.4	NP_004388.2	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 6						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	13	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		ATGGGAATTCTGGGGGGGGAGC	0.426			T	IGH@	B-NHL								8	328	---	---	---	---					
CCNT1	904	broad.mit.edu	37	12	49087434	49087436	+	In_Frame_Del	DEL	ATG	ATG	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr12:49087434_49087436delATG	ENST00000261900.3	-	9	1783_1785	c.1561_1563delCAT	c.(1561-1563)del	p.H521del		NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1	521	His-rich.				cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						AGTGGTGATTATGATGATGATGA	0.443													10	719	---	---	---	---					
LRP10	26020	broad.mit.edu	37	14	23341527	23341529	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr14:23341527_23341529delCCT	ENST00000359591.4	+	1	706_708	c.15_17delCCT	c.(13-18)acc>ac	p.TL5del	LRP10_ENST00000546834.1_In_Frame_Del_p.TL5del	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	5					endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		TGTTGGCCACCCTCCTCCTCCTC	0.670													9	222	---	---	---	---					
BAZ1A	11177	broad.mit.edu	37	14	35331423	35331423	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr14:35331423delT	ENST00000360310.1	-	3	786	c.219delA	c.(217-219)aafs	p.K73fs	BAZ1A_ENST00000553853.1_5'UTR|BAZ1A_ENST00000358716.4_Frame_Shift_Del_p.K73fs|BAZ1A_ENST00000382422.2_Frame_Shift_Del_p.K73fs	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	73	Required for association with the CHRAC1/POLE3 complex.|Required for interaction with NCOR1.|WAC.				chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TCTGTCTTGCTTTTTTTTCTG	0.428													8	381	---	---	---	---					
OTX2-AS1	0	broad.mit.edu	37	14	57508748	57508749	+	RNA	DEL	GA	GA	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	906935a6-9e29-4146-a7a0-d60f2507e774	g.chr14:57508748_57508749delGA	ENST00000554725.1	+	0	344																											TGAAGTTAAGGAGAGAAAAAAG	0.376													15	41	---	---	---	---					
AC073321.4	0	broad.mit.edu	37	2	217475032	217475032	+	RNA	DEL	A	A	-	rs71401156		TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr2:217475032delA	ENST00000441803.1	+	0	195																											ATTTTATTTCAAAAAAAAAAA	0.373													9	11	---	---	---	---					
CRIPAK	285464	broad.mit.edu	37	4	1388441	1388442	+	Frame_Shift_Ins	INS	-	-	CG	rs144787346	byFrequency	TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr4:1388441_1388442insCG	ENST00000324803.4	+	1	3102_3103	c.142_143insCG	c.(142-144)gccfs	p.A48fs		NM_175918.3	NP_787114.2	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	48					ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding			NS(3)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(1)	35			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			CTGCTCACACATGCCCATGTGG	0.644													8	882	---	---	---	---					
FIP1L1	81608	broad.mit.edu	37	4	54319248	54319249	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr4:54319248_54319249delAG	ENST00000337488.6	+	16	1641_1642	c.1447_1448delAG	c.(1447-1449)afs	p.R483fs	FIP1L1_ENST00000358575.5_Frame_Shift_Del_p.R477fs|FIP1L1_ENST00000507166.1_Intron|FIP1L1_ENST00000306932.6_Frame_Shift_Del_p.R409fs	NM_030917.3	NP_112179.2	Q6UN15	FIP1_HUMAN	factor interacting with PAPOLA and CPSF1	483	Arg-rich.|Glu-rich.|Sufficient for interaction with CPSF1 and CSTF3.				mRNA processing	nucleus	RNA binding	p.R487fs*3(2)		large_intestine(3)|liver(1)|ovary(1)|skin(1)	6			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			agaACGCACCAGAGAGAGAGAG	0.470			T	PDGFRA	idiopathic hypereosinophilic syndrome								9	128	---	---	---	---					
PCDH10	57575	broad.mit.edu	37	4	134073569	134073571	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr4:134073569_134073571delCTG	ENST00000264360.4	+	1	3100_3102	c.2274_2276delCTG	c.(2272-2277)ctc>ct	p.LC758del		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	758	Cys-rich.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTGCTGCCTCTGCTGCTGCTGC	0.581													7	86	---	---	---	---					
STK19	8859	broad.mit.edu	37	6	31939825	31939826	+	Frame_Shift_Ins	INS	-	-	G			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr6:31939825_31939826insG	ENST00000375331.2	+	1	218_219	c.52_53insG	c.(52-54)ggcfs	p.G18fs	DOM3Z_ENST00000337523.5_5'UTR|DOM3Z_ENST00000478221.1_5'UTR|STK19_ENST00000375333.2_Frame_Shift_Ins_p.G18fs|DOM3Z_ENST00000375349.3_5'UTR	NM_004197.1	NP_004188.1	P49842	STK19_HUMAN	serine/threonine kinase 19	18						nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			skin(5)|upper_aerodigestive_tract(2)	7						GCGACAGTGGCGGGCAAACCCC	0.634													8	315	---	---	---	---					
DST	667	broad.mit.edu	37	6	56510689	56510690	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr6:56510689_56510690delTC	ENST00000370754.5	-	14	1652_1653	c.1653_1654delGA	c.(1651-1656)gaagfs	p.EK551fs	DST_ENST00000312431.6_Frame_Shift_Del_p.EK373fs|DST_ENST00000361203.3_Frame_Shift_Del_p.EK373fs|DST_ENST00000370769.4_Frame_Shift_Del_p.EK373fs|DST_ENST00000421834.2_Frame_Shift_Del_p.EK373fs|DST_ENST00000370788.2_Frame_Shift_Del_p.EK373fs			Q03001	DYST_HUMAN	dystonin	373					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CGAAGGGCCTTCTCTCTCTCTA	0.441													7	271	---	---	---	---					
PEX1	5189	broad.mit.edu	37	7	92146721	92146721	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr7:92146721delT	ENST00000248633.4	-	5	1203	c.1108delA	c.(1108-1110)ttfs	p.I370fs	PEX1_ENST00000428214.1_Frame_Shift_Del_p.I370fs|PEX1_ENST00000438045.1_Intron|PEX1_ENST00000541751.1_5'UTR	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	370					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCTGACCTAATTTTTTTTTGA	0.353													9	171	---	---	---	---					
KMT2C	58508	broad.mit.edu	37	7	151904428	151904429	+	Frame_Shift_Ins	INS	-	-	A			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr7:151904428_151904429insA	ENST00000355193.2	-	24	4015_4016	c.3797_3798insT	c.(3796-3798)gacfs	p.D1266fs	KMT2C_ENST00000262189.6_Frame_Shift_Ins_p.D1266fs					lysine (K)-specific methyltransferase 2C																		CACCATCTGTTCCTTCCACTCC	0.381													43	102	---	---	---	---					
SLC10A5	347051	broad.mit.edu	37	8	82606545	82606546	+	Frame_Shift_Ins	INS	-	-	C			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr8:82606545_82606546insC	ENST00000518568.1	-	1	1863_1864	c.662_663insG	c.(661-663)gtafs	p.V221fs		NM_001010893.2	NP_001010893.1	Q5PT55	NTCP5_HUMAN	solute carrier family 10, member 5	221						integral to membrane	bile acid:sodium symporter activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)	15						CAAAGAGATAGCCCCCACCCCC	0.470													7	522	---	---	---	---					
KRTAP5-10	387273	broad.mit.edu	37	11	71276657	71276658	+	In_Frame_Ins	INS	-	-	GGCTGTGGCTCCGGCTGTGGG	rs71049990		TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr11:71276657_71276658insGGCTGTGGCTCCGGCTGTGGG	ENST00000398531.1	+	1	49_50	c.24_25insGGCTGTGGCTCCGGCTGTGGG	c.(22-27)gggctg>ggGGCTGTGGCTCCGGCTGTGGGgctg	p.7_8insGAVAPAV	KRTAP5-10_ENST00000376536.4_In_Frame_Ins_p.7_8insGAVAPAV	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	7						keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						GCTGCTCCGGAGGCTGTGGCTC	0.668													95	222	---	---	---	---					
RP11-551L14.1	0	broad.mit.edu	37	12	31269189	31269190	+	RNA	INS	-	-	ATCAT	rs35880498		TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr12:31269189_31269190insATCAT	ENST00000542490.1	-	0	165																				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(25)|prostate(3)|stomach(3)|urinary_tract(1)	41						CATGAGAACTCATTACCATGAT	0.351													5	10	---	---	---	---					
SFSWAP	6433	broad.mit.edu	37	12	132281734	132281736	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr12:132281734_132281736delAGA	ENST00000261674.4	+	16	2687_2689	c.2546_2548delAGA	c.(2545-2550)gag>g	p.EK849del	SFSWAP_ENST00000539506.1_3'UTR|SFSWAP_ENST00000541286.1_In_Frame_Del_p.EK901del	NM_004592.3	NP_004583.2	Q12872	SFSWA_HUMAN	splicing factor, suppressor of white-apricot homolog (Drosophila)	849	Arg/Ser-rich (RS domain).				mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(8)|ovary(1)|skin(2)	25						AGTCCCCACGAGAAGAAGAAGAA	0.606													10	458	---	---	---	---					
OTX2-AS1	0	broad.mit.edu	37	14	57508748	57508749	+	RNA	DEL	GA	GA	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr14:57508748_57508749delGA	ENST00000554725.1	+	0	344																											TGAAGTTAAGGAGAGAAAAAAG	0.376													15	41	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	-	G	rs2981599		TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr16:3119304_3119305insG	ENST00000525643.2	+	7	847_848	c.515_516insG	c.(514-516)gaafs	p.E172fs	IL32_ENST00000534507.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000552664.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000382213.3_Frame_Shift_Ins_p.E163fs|IL32_ENST00000529699.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000440815.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000551122.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000551513.1_Frame_Shift_Ins_p.E209fs|IL32_ENST00000529550.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000530890.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000549213.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000548652.1_Frame_Shift_Ins_p.E163fs|IL32_ENST00000533097.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000552936.1_Frame_Shift_Ins_p.E196fs|IL32_ENST00000396890.2_Frame_Shift_Ins_p.E218fs|IL32_ENST00000008180.9_Frame_Shift_Ins_p.E152fs|IL32_ENST00000396887.3_Frame_Shift_Ins_p.E115fs|IL32_ENST00000444393.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000526464.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000531965.1_Frame_Shift_Ins_p.E162fs|IL32_ENST00000528163.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000552356.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000548246.1_Frame_Shift_Ins_p.E132fs|IL32_ENST00000325568.5_Frame_Shift_Ins_p.E172fs|IL32_ENST00000530538.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000548476.1_Frame_Shift_Ins_p.E218fs			P24001	IL32_HUMAN	interleukin 32	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						CCACGGGGGGACAAGGAGGAGC	0.574													27	653	---	---	---	---					
OR7E24	26648	broad.mit.edu	37	19	9361741	9361741	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr19:9361741delT	ENST00000456448.1	+	1	136	c.22delT	c.(22-24)ttfs	p.F11fs		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	11					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						TCCAATTCTCTTTTTTTTTTT	0.388													7	15	---	---	---	---					
TPTEP1	0	broad.mit.edu	37	22	17131430	17131432	+	RNA	DEL	CAC	CAC	-	rs142037179		TCGA-G9-6373-01A-11D-1786-08	TCGA-G9-6373-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0caf5af2-ae80-4f39-ac6f-c2dbc2e8b820	c817606e-6c86-4fec-a7c7-e514459e4aba	g.chr22:17131430_17131432delCAC	ENST00000426585.1	+	0	2456_2458																											caccatccatcaccaacagaaac	0.443													3	3	---	---	---	---