Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NDUFV1	4723	broad.mit.edu	37	11	67375940	67375940	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr11:67375940A>G	ENST00000322776.6	+	2	299	c.146A>G	c.(145-147)cAt>cGt	p.H49R	NDUFV1_ENST00000415352.2_Missense_Mutation_p.H42R|NDUFV1_ENST00000532303.1_Intron|NDUFV1_ENST00000529927.1_Missense_Mutation_p.H40R	NM_001166102.1|NM_007103.3	NP_001159574.1|NP_009034.2	P49821	NDUV1_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	49					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	16					NADH(DB00157)	TACGGCCGCCATGACTGGAGG	0.557000													22	282					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16590333	16590333	+	Splice_Site	SNP	A	A	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr4:16590333A>G	ENST00000502640.1	-	4	679	c.531_splice	c.e4+1	p.H177_splice	LDB2_ENST00000503178.2_Splice_Site_p.H53_splice|LDB2_ENST00000441778.2_Splice_Site_p.H177_splice|LDB2_ENST00000515064.1_Splice_Site_p.H177_splice|LDB2_ENST00000503829.1_5'UTR|LDB2_ENST00000304523.5_Splice_Site_p.H177_splice			O43679	LDB2_HUMAN	LIM domain binding 2	177							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						AATTACTTACATGCATGGCTA	0.388000													12	76					0	0	1	0	0
UROC1	131669	broad.mit.edu	37	3	126202303	126202303	+	Missense_Mutation	SNP	A	A	G	rs141282463		TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr3:126202303A>G	ENST00000290868.2	-	19	1852	c.1799T>C	c.(1798-1800)gTg>gCg	p.V600A	UROC1_ENST00000383579.3_Missense_Mutation_p.V660A	NM_144639.2	NP_653240.1	Q96N76	HUTU_HUMAN	urocanate hydratase 1	600					histidine catabolic process	cytosol	urocanate hydratase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(1)|skin(1)	39				GBM - Glioblastoma multiforme(114;0.17)		CCCGTTGATCACCTCACCCCT	0.597000													8	41					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159653589	159653589	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr6:159653589G>A	ENST00000297267.9	+	11	2245	c.2045G>A	c.(2044-2046)cGc>cAc	p.R682H	FNDC1_ENST00000340366.6_Missense_Mutation_p.R619H	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	682	Ser-rich.					extracellular region		p.R682H(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		AGCGTTCTCCGCGACAGAAGC	0.716000													7	52					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121961146	121961146	+	Silent	SNP	C	C	T			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr4:121961146C>T	ENST00000379692.4	-	3	778	c.252G>A	c.(250-252)gcG>gcA	p.A84A		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	84										breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						ACTCCAAAGGCGCATCACAGG	0.522000													5	99					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310294	24310294	+	Missense_Mutation	SNP	T	T	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr19:24310294T>G	ENST00000357002.4	+	4	1607	c.1492T>G	c.(1492-1494)Tct>Gct	p.S498A	ZNF254_ENST00000342944.6_Missense_Mutation_p.S413A	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	498					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATGTGGCAAATCTTTTAGCCA	0.408000													4	84					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179745955	179745955	+	Splice_Site	SNP	C	C	T			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr5:179745955C>T	ENST00000253778.8	-	10	965	c.794_splice	c.e10-1	p.A266_splice	GFPT2_ENST00000520165.1_5'UTR	NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	266	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	TCTATGATAGCGCTGGGGCAA	0.607000													8	34					0	0	1	0	0
TPCN2	219931	broad.mit.edu	37	11	68822730	68822730	+	Nonsense_Mutation	SNP	C	C	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr11:68822730C>A	ENST00000294309.3	+	4	440	c.339C>A	c.(337-339)taC>taA	p.Y113*	TPCN2_ENST00000542467.1_Nonsense_Mutation_p.Y113*|TPCN2_ENST00000442692.2_3'UTR	NM_139075.3	NP_620714.2	Q8NHX9	TPC2_HUMAN	two pore segment channel 2	113					cellular calcium ion homeostasis|smooth muscle contraction	endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated calcium channel activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	32			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ACGTGCGCTACCGCGCTGCTC	0.617000													22	155					5.35356e-11	5.68816e-11	1	1	0
PSME1	5720	broad.mit.edu	37	14	24606557	24606557	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr14:24606557A>G	ENST00000382708.3	+	4	226	c.163A>G	c.(163-165)Agc>Ggc	p.S55G	PSME1_ENST00000561435.1_Missense_Mutation_p.S55G|PSME1_ENST00000206451.6_Missense_Mutation_p.S55G|PSME1_ENST00000470718.1_3'UTR|PSME1_ENST00000559123.1_5'UTR	NM_176783.1	NP_788955.1	Q06323	PSME1_HUMAN	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	55			S -> N (in dbSNP:rs1803830).		anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|proteasome activator complex				endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				GBM - Glioblastoma multiforme(265;0.00831)		AGCCAACTTGAGCAATCTGAA	0.557000													8	137					0	0	1	0	0
SPRR2F	0	broad.mit.edu	37	1	153085010	153085010	+	Missense_Mutation	SNP	C	C	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr1:153085010C>A	ENST00000468739.1	-	2	260	c.200G>T	c.(199-201)tGt>tTt	p.C67F	SPRR2B_ENST00000368752.4_Intron	NM_001014450.1	NP_001014450.1	Q96RM1	SPR2F_HUMAN	small proline-rich protein 2F	67					keratinization	cornified envelope|cytoplasm		p.C67F(1)		large_intestine(1)|lung(1)|prostate(1)|urinary_tract(1)	4	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTTGGGTGGACACTTTGGCTG	0.542000													7	286					2.74318e-10	2.85515e-10	1	1	0
PDIK1L	149420	broad.mit.edu	37	1	26449050	26449050	+	Silent	SNP	T	T	C			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr1:26449050T>C	ENST00000374271.4	+	4	1295	c.1008T>C	c.(1006-1008)gaT>gaC	p.D336D	PDIK1L_ENST00000374269.1_Silent_p.D336D	NM_001243532.1|NM_001243533.1|NM_152835.4	NP_001230461.1|NP_001230462.1|NP_690048.1	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	336						nucleus	ATP binding|protein serine/threonine kinase activity			large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	7		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		CATTTAAAGATAGCAGCTGGG	0.373000													6	62					0	0	1	0	0
TEX29	121793	broad.mit.edu	37	13	111996453	111996453	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr13:111996453G>A	ENST00000283547.1	+	6	568	c.439G>A	c.(439-441)Gaa>Aaa	p.E147K		NM_152324.1	NP_689537.1	Q8N6K0	CM016_HUMAN	testis expressed 29	147						integral to membrane											AACAGAAGCCGAAGAAACTGA	0.378000													5	53					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38431360	38431360	+	Missense_Mutation	SNP	T	T	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr5:38431360T>A	ENST00000322350.5	+	15	2482	c.2136T>A	c.(2134-2136)gaT>gaA	p.D712E	EGFLAM_ENST00000336740.6_Missense_Mutation_p.D478E|EGFLAM_ENST00000354891.3_Missense_Mutation_p.D712E|EGFLAM_ENST00000397202.2_Missense_Mutation_p.D78E	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	712	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TACAGGTGGATAAGCAGAAGA	0.478000													11	65					0	0	1	0	0
STXBP2	6813	broad.mit.edu	37	19	7707903	7707903	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr19:7707903A>G	ENST00000441779.2	+	12	1065	c.1028A>G	c.(1027-1029)aAg>aGg	p.K343R	STXBP2_ENST00000414284.2_Missense_Mutation_p.K329R|STXBP2_ENST00000221283.5_Missense_Mutation_p.K332R	NM_001272034.1	NP_001258963.1	Q15833	STXB2_HUMAN	syntaxin binding protein 2	332					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	23						ATCCTGAAAAAGATGCCGCAG	0.612000													4	148					0	0	1	0	0
RPS27A	6233	broad.mit.edu	37	2	55462094	55462094	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr2:55462094A>G	ENST00000272317.6	+	5	641	c.317A>G	c.(316-318)tAt>tGt	p.Y106C	RPS27A_ENST00000404735.1_Missense_Mutation_p.Y106C|RPS27A_ENST00000402285.3_Missense_Mutation_p.Y106C	NM_002954.5	NP_002945.1	P62979	RS27A_HUMAN	ribosomal protein S27a	106					activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	metal ion binding|structural constituent of ribosome			cervix(1)|ovary(1)|urinary_tract(1)	3						CTGAAATATTATAAGGTGAGC	0.378000													5	24					0	0	1	0	0
TRUB1	142940	broad.mit.edu	37	10	116734977	116734977	+	Missense_Mutation	SNP	A	A	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr10:116734977A>G	ENST00000298746.3	+	8	950	c.889A>G	c.(889-891)Att>Gtt	p.I297V		NM_139169.4	NP_631908.1	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase family member 1	297					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(2)|kidney(2)|large_intestine(1)|lung(5)|urinary_tract(2)	12		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		CAAATGGACAATTGATGACAT	0.433000													16	149					0	0	1	0	0
HIST1H4H	8365	broad.mit.edu	37	6	26285590	26285590	+	Silent	SNP	T	T	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr6:26285590T>G	ENST00000289352.1	-	1	172	c.138A>C	c.(136-138)cgA>cgC	p.R46R	HIST1H4H_ENST00000377727.1_Silent_p.R46R			P62805	H4_HUMAN	histone cluster 1, H4h	46					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(2)|ovary(2)|upper_aerodigestive_tract(3)	7						GGCCAGAAATTCGCTTGACAC	0.547000										HNSCC(76;0.23)			11	124					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75814962	75814962	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr6:75814962G>A	ENST00000322507.8	-	54	8534	c.8225C>T	c.(8224-8226)aCa>aTa	p.T2742I	COL12A1_ENST00000345356.6_Missense_Mutation_p.T1578I|COL12A1_ENST00000483888.2_Missense_Mutation_p.T2742I|COL12A1_ENST00000416123.2_Missense_Mutation_p.T2666I	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2742	Nonhelical region (NC3).				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						GCTGTCCTGTGTACATGTGCA	0.378000													4	48					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6262661	6262661	+	Splice_Site	SNP	G	G	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr11:6262661G>A	ENST00000379936.2	+	5	1033	c.917_splice	c.e5-1	p.W306_splice	CNGA4_ENST00000533426.1_Splice_Site_p.W75_splice	NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	306					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTACTCTCAGGTATCAGCACC	0.552000													21	110					0	0	1	0	0
ARRB2	409	broad.mit.edu	37	17	4619828	4619828	+	Silent	SNP	A	A	C			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr17:4619828A>C	ENST00000269260.2	+	5	515	c.282A>C	c.(280-282)ccA>ccC	p.P94P	ARRB2_ENST00000381488.6_Silent_p.P79P|ARRB2_ENST00000572457.1_5'UTR|ARRB2_ENST00000575877.1_Silent_p.P94P|ARRB2_ENST00000346341.2_Silent_p.P79P|ARRB2_ENST00000574954.1_5'UTR|ARRB2_ENST00000570718.1_3'UTR|ARRB2_ENST00000412477.3_Silent_p.P94P|ARRB2_ENST00000571206.1_5'UTR	NM_001257328.1|NM_001257330.1|NM_004313.3	NP_001244257.1|NP_001244259.1|NP_004304.1	P32121	ARRB2_HUMAN	arrestin, beta 2	94					cell chemotaxis|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|G-protein coupled receptor internalization|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|platelet activation|positive regulation of ERK1 and ERK2 cascade|proteasomal ubiquitin-dependent protein catabolic process|protein transport|protein ubiquitination|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway	coated pit|cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	angiotensin receptor binding|ubiquitin protein ligase binding			large_intestine(1)|liver(2)|lung(3)|prostate(1)	7						TGCCCAACCCACCCCGGCCCC	0.667000													6	27					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000330386.6_Silent_p.Q2644Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													6	70					0	0	1	0	0
CLPB	81570	broad.mit.edu	37	11	72028171	72028171	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr11:72028171C>T	ENST00000294053.3	-	8	1230	c.1057G>A	c.(1057-1059)Gcc>Acc	p.A353T	CLPB_ENST00000543042.1_Missense_Mutation_p.A152T|CLPB_ENST00000437826.2_Missense_Mutation_p.A308T|CLPB_ENST00000538039.1_Missense_Mutation_p.A323T|CLPB_ENST00000340729.5_Missense_Mutation_p.A294T	NM_001258394.1|NM_030813.4	NP_001245323.1|NP_110440.1	Q9H078	CLPB_HUMAN	ClpB caseinolytic peptidase B homolog (E. coli)	353					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	19						GTGGCGATGGCGCTCTCCTGG	0.612000													4	171					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53569195	53569195	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr8:53569195G>A	ENST00000025008.5	-	15	3717	c.3194C>T	c.(3193-3195)gCg>gTg	p.A1065V	RB1CC1_ENST00000435644.2_Missense_Mutation_p.A1065V|RB1CC1_ENST00000539297.1_Missense_Mutation_p.A1065V|RB1CC1_ENST00000521611.1_Intron	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	1065					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TTCCTTCAACGCAAGTTCAAC	0.383000													3	44					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10452394	10452394	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr3:10452394G>A	ENST00000397077.1	-	5	880	c.305C>T	c.(304-306)gCg>gTg	p.A102V	ATP2B2_ENST00000360273.2_Missense_Mutation_p.A102V|ATP2B2_ENST00000352432.4_Missense_Mutation_p.A102V|ATP2B2_ENST00000343816.4_Missense_Mutation_p.A102V|ATP2B2_ENST00000383800.4_Missense_Mutation_p.A102V			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	102					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						GTCCTGCAGCGCCTCCCACAC	0.562000													31	490					0	0	1	0	0
SEPHS2	22928	broad.mit.edu	37	16	30456444	30456444	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr16:30456444G>A	ENST00000478753.2	-	1	1058	c.605C>T	c.(604-606)gCg>gTg	p.A202V	SEPHS2_ENST00000542752.1_Missense_Mutation_p.A145V|SEPHS2_ENST00000500504.2_Missense_Mutation_p.A202V			Q99611	SPS2_HUMAN	selenophosphate synthetase 2	202					selenocysteine biosynthetic process		ATP binding|selenide, water dikinase activity			breast(3)|cervix(1)|kidney(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	10						TTCCTCAGCCGCATCCCGAAA	0.527000													4	128					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24564490	24564490	+	Nonsense_Mutation	SNP	G	G	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr6:24564490G>A	ENST00000535378.1	-	16	2986	c.2344C>T	c.(2344-2346)Cga>Tga	p.R782*	KIAA0319_ENST00000543707.1_Nonsense_Mutation_p.R791*|KIAA0319_ENST00000537886.1_Nonsense_Mutation_p.R791*|KIAA0319_ENST00000430948.2_Nonsense_Mutation_p.R746*|KIAA0319_ENST00000378214.3_Nonsense_Mutation_p.R791*	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	791	PKD 5.				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						TCGGTGACTCGCAAGTGGAAA	0.587000													4	71					0	0	1	0	0
TMEM150B	284417	broad.mit.edu	37	19	55831946	55831946	+	Silent	SNP	A	A	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr19:55831946A>G	ENST00000326652.4	-	4	290	c.108T>C	c.(106-108)agT>agC	p.S36S	TMEM150B_ENST00000438693.1_Silent_p.S36S			A6NC51	T150B_HUMAN	transmembrane protein 150B	36						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3						GAAAGCCTTTACTGAGGTCCA	0.527000													5	171					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35778739	35778739	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr3:35778739G>A	ENST00000187397.4	+	16	1985	c.1529G>A	c.(1528-1530)cGa>cAa	p.R510Q	ARPP21_ENST00000444190.1_Missense_Mutation_p.R456Q|ARPP21_ENST00000417925.1_Missense_Mutation_p.R476Q|ARPP21_ENST00000458225.1_Missense_Mutation_p.R476Q|ARPP21_ENST00000337271.5_Missense_Mutation_p.R456Q	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	510	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						CAGCCCCTGCGAAGCGCCATG	0.612000													11	108					0	0	1	0	0
TRIM22	10346	broad.mit.edu	37	11	5730757	5730757	+	Missense_Mutation	SNP	T	T	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr11:5730757T>G	ENST00000379965.3	+	8	1653	c.1376T>G	c.(1375-1377)gTc>gGc	p.V459G	TRIM5_ENST00000380027.1_Intron	NM_001199573.1|NM_006074.4	NP_001186502.1|NP_006065.2	Q8IYM9	TRI22_HUMAN	tripartite motif containing 22	459	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			kidney(3)|large_intestine(8)|lung(9)|prostate(1)|stomach(2)	23		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		TTTTTCAATGTCACAAACCAC	0.463000													12	157					0	0	1	0	0
HIST1H3F	8968	broad.mit.edu	37	6	26250482	26250482	+	Missense_Mutation	SNP	C	C	T			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr6:26250482C>T	ENST00000446824.2	-	1	353	c.352G>A	c.(352-354)Gtg>Atg	p.V118M		NM_021018.2	NP_066298.1	P68431	H31_HUMAN	histone cluster 1, H3f	118					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			lung(6)|urinary_tract(1)	7						ATGATAGTCACTCGCTTGGCG	0.582000											OREG0017241	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	119					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310305	24310305	+	Silent	SNP	A	A	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr19:24310305A>G	ENST00000357002.4	+	4	1618	c.1503A>G	c.(1501-1503)caA>caG	p.Q501Q	ZNF254_ENST00000342944.6_Silent_p.Q416Q	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	501					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				CTTTTAGCCAATCCTCAACCC	0.403000													4	77					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71346947	71346947	+	Silent	SNP	A	A	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr4:71346947A>G	ENST00000413702.1	+	4	774	c.486A>G	c.(484-486)ccA>ccG	p.P162P	MUC7_ENST00000304887.5_Silent_p.P162P|MUC7_ENST00000514512.1_3'UTR|MUC7_ENST00000456088.1_Silent_p.P162P	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	162	Thr-rich.			P -> A (in Ref. 4; AA sequence and 5; AA sequence).		extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			CCCCAGCTCCACAAGACACCA	0.517000													5	190					0	0	1	0	0
CEP170P1	0	broad.mit.edu	37	4	119461491	119461491	+	RNA	SNP	G	G	C			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr4:119461491G>C	ENST00000412784.2	+	0	388					NR_003135.2																						TCAAGCAGCAGAGCCTCCCGA	0.448000													7	29					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31809236	31809236	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr10:31809236C>T	ENST00000446923.2	+	7	1316	c.925C>T	c.(925-927)Cga>Tga	p.R309*	ZEB1_ENST00000542815.3_Nonsense_Mutation_p.R258*|ZEB1_ENST00000560721.2_Nonsense_Mutation_p.R305*|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000361642.5_Nonsense_Mutation_p.R326*|ZEB1_ENST00000320985.10_Nonsense_Mutation_p.R325*	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	325					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				CAGTCCCACACGACCACAGAT	0.428000													6	49					0	0	1	0	0
ZNF583	147949	broad.mit.edu	37	19	56935562	56935562	+	Missense_Mutation	SNP	G	G	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr19:56935562G>A	ENST00000333201.9	+	5	1745	c.1535G>A	c.(1534-1536)aGa>aAa	p.R512K	ZNF583_ENST00000291598.7_Missense_Mutation_p.R512K|ZNF583_ENST00000585612.1_Intron	NM_001159861.1|NM_152478.2	NP_001153333.1|NP_689691.2	Q96ND8	ZN583_HUMAN	zinc finger protein 583	512					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		CTACATCAGAGAATTCATACT	0.388000													19	104					0	0	1	0	0
CREB3L2	64764	broad.mit.edu	37	7	137569739	137569739	+	Splice_Site	SNP	A	A	G			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr7:137569739A>G	ENST00000330387.6	-	10	1622		c.e10+1		CREB3L2_ENST00000456390.1_Silent_p.G424G	NM_194071.3	NP_919047.2	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like 2						chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	breast(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						ATGCTGTCTTACCCACGGAGG	0.522000			T	FUS	fibromyxoid sarcoma								22	140					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47836289	47836289	+	Missense_Mutation	SNP	A	A	C			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr21:47836289A>C	ENST00000359568.5	+	30	6564	c.6457A>C	c.(6457-6459)Aat>Cat	p.N2153H	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	2153					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GTGTGATGCCAATACAACCCC	0.443000													22	95					0	0	1	0	0
SLC7A9	11136	broad.mit.edu	37	19	33355594	33355594	+	Missense_Mutation	SNP	G	G	A	rs146154087		TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr19:33355594G>A	ENST00000023064.4	-	3	367	c.176C>T	c.(175-177)aCg>aTg	p.T59M	SLC7A9_ENST00000587772.1_Missense_Mutation_p.T59M|SLC7A9_ENST00000590341.1_Missense_Mutation_p.T59M	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	59					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	CACAGCTTCCGTGTTGCTGAG	0.612000													5	230					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214557031	214557031	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr1:214557031delG	ENST00000366956.5	-	13	2361	c.2167delC	c.(2167-2169)agfs	p.Q723fs	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	723					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		ATGGGGATCTGGGGCACCGAT	0.617													9	98	---	---	---	---					
FRG1	2483	broad.mit.edu	37	4	190873437	190873439	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr4:190873437_190873439delAAG	ENST00000226798.4	+	3	476_478	c.254_256delAAG	c.(253-258)aaa>a	p.KE85del	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	85					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		GCTCCACACAAAGAAGGTTTGTG	0.414													8	234	---	---	---	---					
RASGEF1A	221002	broad.mit.edu	37	10	43698747	43698747	+	Splice_Site	DEL	T	T	-			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr10:43698747delT	ENST00000395809.1	-	3	2826	c.321_splice	c.e3+1	p.K107_splice	RASGEF1A_ENST00000374459.1_Splice_Site_p.K115_splice|RASGEF1A_ENST00000395810.1_Splice_Site_p.K107_splice|RASGEF1A_ENST00000472864.1_5'UTR			Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	107	N-terminal Ras-GEF.				cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)	11						CCGCCTCACCTTTTCAGGCCC	0.697													2	4	---	---	---	---					
B4GALNT4	338707	broad.mit.edu	37	11	376692	376692	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr11:376692delA	ENST00000329962.6	+	14	1569	c.1569delA	c.(1567-1569)ccfs	p.P523fs		NM_178537.4	NP_848632.2	Q76KP1	B4GN4_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 4	523	Pro-rich.					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGCCGCCCCCAAAGGTGTACG	0.771													2	4	---	---	---	---					
MYO7A	4647	broad.mit.edu	37	11	76901186	76901186	+	Splice_Site	DEL	T	T	-			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr11:76901186delT	ENST00000409709.3	+	29	4022		c.e29+2		MYO7A_ENST00000409619.2_Splice_Site|MYO7A_ENST00000458637.2_Splice_Site	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA						actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GAGCTGCAGGTTCgtgcgtgt	0.622													2	4	---	---	---	---					
RP11-26F2.1	0	broad.mit.edu	37	15	23131706	23131706	+	RNA	DEL	A	A	-			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr15:23131706delA	ENST00000560053.1	-	0	129																											GATATTCTCCAATGTCATTTT	0.259													5	4	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													5	10	---	---	---	---					
MIR3648	0	broad.mit.edu	37	21	9825852	9825853	+	RNA	INS	-	-	A			TCGA-HC-A6AS-01A-11D-A30E-08	TCGA-HC-A6AS-10A-01D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4fb4b9c0-ff21-4077-8c20-0e3acc8d0b39	b4701be8-2c61-4a86-8220-6b3a3550b60e	g.chr21:9825852_9825853insA	ENST00000581792.1	+	0	21_22					NR_037421.1																						gcggcggtggtggggggagccg	0.837													4	3	---	---	---	---