Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NRDE2	55051	broad.mit.edu	37	14	90770672	90770672	+	Missense_Mutation	SNP	T	T	C			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr14:90770672T>C	ENST00000354366.3	-	5	844	c.612A>G	c.(610-612)atA>atG	p.I204M	NRDE2_ENST00000357904.3_De_novo_Start_InFrame	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		CTTCCCAAGATATGCACTGCT	0.413000													11	46					0	0	1	0	0
KRT33B	3884	broad.mit.edu	37	17	39520187	39520187	+	Silent	SNP	G	G	A	rs139682874		TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr17:39520187G>A	ENST00000251646.3	-	7	1165	c.1116C>T	c.(1114-1116)tgC>tgT	p.C372C		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	372	Tail.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				TGGTGGTGGCGCAGGGGTTGG	0.522000													3	56					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84606322	84606322	+	Missense_Mutation	SNP	C	C	G			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr9:84606322C>G	ENST00000344803.2	+	4	984	c.937C>G	c.(937-939)Cag>Gag	p.Q313E		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		CACTGTGACTCAGTCTAAATC	0.478000													82	169					0	0	1	0	0
FIGN	55137	broad.mit.edu	37	2	164466569	164466569	+	Silent	SNP	G	G	C			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr2:164466569G>C	ENST00000333129.3	-	3	2087	c.1773C>G	c.(1771-1773)ctC>ctG	p.L591L	FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	591						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						CTTGAGAGGAGAGAAGCATGT	0.468000													7	57					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151773137	151773137	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr4:151773137G>A	ENST00000535741.1	-	23	4198	c.3725C>T	c.(3724-3726)gCg>gTg	p.A1242V	LRBA_ENST00000507224.1_Missense_Mutation_p.A1242V|LRBA_ENST00000357115.3_Missense_Mutation_p.A1242V|LRBA_ENST00000510413.1_Missense_Mutation_p.A1242V			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1242						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					ATCCAACTTCGCAATCTTTTG	0.453000													3	38					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139905804	139905804	+	Silent	SNP	G	G	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr5:139905804G>A	ENST00000297183.6	+	26	4840	c.4716G>A	c.(4714-4716)aaG>aaA	p.K1572K	ANKHD1-EIF4EBP3_ENST00000532219.1_Silent_p.K1572K|ANKHD1_ENST00000360839.2_Silent_p.K1572K|ANKHD1_ENST00000544120.1_5'UTR	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCAACAAAAGGCAGATAAAA	0.393000													4	190					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4874799	4874799	+	Silent	SNP	G	G	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr7:4874799G>A	ENST00000399583.3	-	4	1042	c.855C>T	c.(853-855)agC>agT	p.S285S	RADIL_ENST00000536091.1_Silent_p.S285S|RADIL_ENST00000538469.1_Silent_p.S45S	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	285					cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		AGAGGCTGATGCTGGGCTTGC	0.692000													4	15					0	0	1	0	0
TMEM72	643236	broad.mit.edu	37	10	45430339	45430339	+	Missense_Mutation	SNP	G	G	T			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr10:45430339G>T	ENST00000544540.1	+	4	715	c.231G>T	c.(229-231)aaG>aaT	p.K77N	TMEM72-AS1_ENST00000450287.2_RNA			A0PK05	TMM72_HUMAN	transmembrane protein 72	195						integral to membrane				breast(2)|kidney(1)|large_intestine(2)|lung(10)	15						GGACTAAGAAGCCCAGTGCCC	0.582000													5	171					0.184627	0.184627	1	1	0
FGF4	2249	broad.mit.edu	37	11	69588217	69588217	+	Missense_Mutation	SNP	G	G	T	rs140567674	byFrequency	TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr11:69588217G>T	ENST00000168712.1	-	3	799	c.481C>A	c.(481-483)Ctc>Atc	p.L161I	FGF4_ENST00000538040.1_5'UTR	NM_002007.2	NP_001998.1	P08620	FGF4_HUMAN	fibroblast growth factor 4	161					cell-cell signaling|chondroblast differentiation|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade	extracellular region	growth factor activity|heparin binding			lung(3)	3	Melanoma(5;1.89e-05)		LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)		Pentosan Polysulfate(DB00686)	TTGGGAAGGAGAATCTCCTTG	0.567000													5	116					2.0095e-06	2.14346e-06	1	1	0
OR7D4	125958	broad.mit.edu	37	19	9325026	9325026	+	Missense_Mutation	SNP	A	A	C			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr19:9325026A>C	ENST00000308682.2	-	1	516	c.488T>G	c.(487-489)aTg>aGg	p.M163R		NM_001005191.2	NP_001005191.1	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D, member 4	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|skin(3)|stomach(1)	26						CAACCTCTTCATCAGTAGAAT	0.512000													20	52					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76349085	76349085	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr14:76349085G>A	ENST00000298832.9	+	30	3785	c.3580G>A	c.(3580-3582)Gca>Aca	p.A1194T	TTLL5_ENST00000557636.1_Missense_Mutation_p.A1209T|TTLL5_ENST00000554510.1_Missense_Mutation_p.A703T|TTLL5_ENST00000556893.1_Missense_Mutation_p.A745T	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1194					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		GAATAATGGTGCAGGTTGTAG	0.453000													17	60					0	0	1	0	0
CEP44	80817	broad.mit.edu	37	4	175225405	175225405	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr4:175225405C>T	ENST00000503780.1	+	6	806	c.392C>T	c.(391-393)tCa>tTa	p.S131L	CEP44_ENST00000426172.1_Missense_Mutation_p.S131L|CEP44_ENST00000457424.2_Missense_Mutation_p.S131L|CEP44_ENST00000296519.4_Missense_Mutation_p.S131L	NM_001040157.2	NP_001035247.1	Q9C0F1	CEP44_HUMAN	centrosomal protein 44kDa	131						centrosome|midbody|spindle pole				endometrium(2)|large_intestine(4)|lung(5)|stomach(1)	12						TAGATTCCATCACAACAAAGA	0.303000													9	51					0	0	1	0	0
NLRX1	79671	broad.mit.edu	37	11	119045313	119045313	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr11:119045313C>T	ENST00000409109.1	+	6	1588	c.1001C>T	c.(1000-1002)gCc>gTc	p.A334V	NLRX1_ENST00000409265.4_Missense_Mutation_p.A334V|NLRX1_ENST00000525863.1_Missense_Mutation_p.A334V|NLRX1_ENST00000409991.1_Missense_Mutation_p.A334V|NLRX1_ENST00000292199.2_Missense_Mutation_p.A334V			Q86UT6	NLRX1_HUMAN	NLR family member X1	334	NACHT.|Required for interaction with MAVS.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production	mitochondrial outer membrane	ATP binding			cervix(1)|endometrium(2)|kidney(2)|lung(10)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	22	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TGCGGGTATGCCGTTGGCGGT	0.607000													4	166					0	0	1	0	0
HNRNPR	10236	broad.mit.edu	37	1	23637361	23637361	+	Silent	SNP	G	G	C			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr1:23637361G>C	ENST00000478691.1	-	10	1465	c.1194C>G	c.(1192-1194)ggC>ggG	p.G398G	HNRNPR_ENST00000427764.2_Silent_p.G458G|HNRNPR_ENST00000426846.2_Silent_p.G336G|HNRNPR_ENST00000606561.1_Silent_p.G357G|HNRNPR_ENST00000374616.3_Silent_p.G499G|HNRNPR_ENST00000302271.6_Silent_p.G496G|HNRNPR_ENST00000476660.1_5'UTR|HNRNPR_ENST00000374612.1_Silent_p.G496G	NM_001102397.1|NM_001102399.1	NP_001095867.1|NP_001095869.1	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	496	RRM 3.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		ttactGCATAGCCATCATCAT	0.498000													27	67					0	0	1	0	0
LONP1	9361	broad.mit.edu	37	19	5711843	5711843	+	Missense_Mutation	SNP	A	A	C			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr19:5711843A>C	ENST00000360614.3	-	4	966	c.809T>G	c.(808-810)gTg>gGg	p.V270G	LONP1_ENST00000540670.2_Missense_Mutation_p.V74G|LONP1_ENST00000585374.1_Missense_Mutation_p.V156G|LONP1_ENST00000593119.1_Missense_Mutation_p.V206G|LONP1_ENST00000590729.1_Missense_Mutation_p.V156G	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	270	Lon.				cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CACCATGAGCACCTCAGCCGG	0.657000													7	69					0	0	1	0	0
WIPI1	55062	broad.mit.edu	37	17	66440641	66440641	+	Silent	SNP	G	G	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr17:66440641G>A	ENST00000262139.5	-	4	422	c.423C>T	c.(421-423)aaC>aaT	p.N141N	WIPI1_ENST00000589459.1_5'UTR|WIPI1_ENST00000546360.1_Silent_p.N59N	NM_017983.5	NP_060453.3	Q5MNZ9	WIPI1_HUMAN	WD repeat domain, phosphoinositide interacting 1	141					macroautophagy|vesicle targeting, trans-Golgi to endosome	autophagic vacuole membrane|clathrin-coated vesicle|cytosol|endosome membrane|PAS complex|pre-autophagosomal structure membrane|trans-Golgi network	androgen receptor binding|estrogen receptor binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	18						CACCTGTTGGGTTTGCAGGAA	0.423000													19	53					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310294	24310294	+	Missense_Mutation	SNP	T	T	G			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr19:24310294T>G	ENST00000357002.4	+	4	1607	c.1492T>G	c.(1492-1494)Tct>Gct	p.S498A	ZNF254_ENST00000342944.6_Missense_Mutation_p.S413A	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	498					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATGTGGCAAATCTTTTAGCCA	0.408000													3	70					0	0	1	0	0
BRPF1	7862	broad.mit.edu	37	3	9780727	9780727	+	Missense_Mutation	SNP	A	A	G			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr3:9780727A>G	ENST00000383829.2	+	3	1048	c.644A>G	c.(643-645)tAt>tGt	p.Y215C	BRPF1_ENST00000457855.1_Missense_Mutation_p.Y215C|BRPF1_ENST00000302054.3_Missense_Mutation_p.Y215C|BRPF1_ENST00000424362.1_Missense_Mutation_p.Y215C|BRPF1_ENST00000433861.2_Missense_Mutation_p.Y215C	NM_001003694.1	NP_001003694.1	P55201	BRPF1_HUMAN	bromodomain and PHD finger containing, 1	215	Interaction with MYST3 and MYST4.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	49	Medulloblastoma(99;0.227)					GAAGTAGAGTATGACATGGAC	0.498000													8	43					0	0	1	0	0
NOSTRIN	115677	broad.mit.edu	37	2	169716116	169716116	+	Missense_Mutation	SNP	G	G	T			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr2:169716116G>T	ENST00000444448.2	+	16	1795	c.1319G>T	c.(1318-1320)tGt>tTt	p.C440F	NOSTRIN_ENST00000445023.2_Missense_Mutation_p.C305F|NOSTRIN_ENST00000317647.7_Missense_Mutation_p.C383F|NOSTRIN_ENST00000421711.2_Missense_Mutation_p.C355F|NOSTRIN_ENST00000458381.2_Missense_Mutation_p.C440F|NOSTRIN_ENST00000397209.2_Missense_Mutation_p.C355F|NOSTRIN_ENST00000397206.2_Missense_Mutation_p.C305F			Q8IVI9	NOSTN_HUMAN	nitric oxide synthase trafficking	383	SH3.				endocytosis|nitric oxide metabolic process|regulation of nitric-oxide synthase activity	cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	9						AGCCATCCTTGTAGTAATTCC	0.433000													4	98					0.014758	0.015072	1	1	0
IL1R2	7850	broad.mit.edu	37	2	102632417	102632417	+	Silent	SNP	G	G	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr2:102632417G>A	ENST00000332549.3	+	4	646	c.417G>A	c.(415-417)ccG>ccA	p.P139P	IL1R2_ENST00000393414.2_Silent_p.P139P|IL1R2_ENST00000441002.1_Silent_p.P139P	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	139	Ig-like C2-type 2.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	TCTCATACCCGCAAATTTTAA	0.413000													3	61					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7060028	7060028	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr11:7060028G>A	ENST00000299481.4	+	2	557	c.211G>A	c.(211-213)Gcc>Acc	p.A71T		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	71	DAPIN.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AGGAGAGAAAGCCTGGAGTGT	0.483000													6	34					0	0	1	0	0
MLLT4	4301	broad.mit.edu	37	6	168352505	168352505	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr6:168352505C>T	ENST00000366806.2	+	30	4592	c.4450C>T	c.(4450-4452)Cag>Tag	p.Q1484*	MLLT4_ENST00000351017.4_Nonsense_Mutation_p.Q1491*|MLLT4_ENST00000447894.2_Nonsense_Mutation_p.Q1484*|MLLT4_ENST00000344191.4_Nonsense_Mutation_p.Q1484*|MLLT4_ENST00000400822.3_Nonsense_Mutation_p.Q1483*|MLLT4_ENST00000392108.3_Nonsense_Mutation_p.Q1484*|MLLT4_ENST00000392112.1_Nonsense_Mutation_p.Q1467*			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	1484					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		GCTGCAGCCTCAGCAGCAGCC	0.597000			T	MLL	AL								19	106					0	0	1	0	0
HECA	51696	broad.mit.edu	37	6	139487664	139487664	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr6:139487664C>T	ENST00000367658.2	+	2	800	c.515C>T	c.(514-516)gCc>gTc	p.A172V	RP1-225E12.2_ENST00000588638.1_RNA|RP1-225E12.2_ENST00000590679.1_RNA|RP1-225E12.2_ENST00000589192.1_RNA|RP1-225E12.2_ENST00000586229.1_RNA|RP1-225E12.2_ENST00000415194.2_RNA|RP1-225E12.2_ENST00000588529.1_RNA|RP1-225E12.2_ENST00000587577.1_RNA|RP1-225E12.2_ENST00000586266.1_RNA|RP1-225E12.3_ENST00000585874.1_RNA	NM_016217.2	NP_057301.1	Q9UBI9	HDC_HUMAN	headcase homolog (Drosophila)	172					respiratory tube development					endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)	15				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		TACGACCTGGCCTTCCGCTTC	0.572000													22	70					0	0	1	0	0
RPL15	6138	broad.mit.edu	37	3	23960791	23960791	+	Silent	SNP	C	C	T			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr3:23960791C>T	ENST00000307839.5	+	4	1053	c.414C>T	c.(412-414)ttC>ttT	p.F138F	RPL15_ENST00000413699.1_Silent_p.F138F|RPL15_ENST00000354811.5_Silent_p.F138F|RPL15_ENST00000415719.1_Silent_p.F138F|RPL15_ENST00000435882.1_Silent_p.F138F|RPL15_ENST00000456530.2_Intron|NKIRAS1_ENST00000421515.2_Intron	NM_001253379.1|NM_001253380.1|NM_002948.3	NP_001240308.1|NP_001240309.1|NP_002939.2	P61313	RL15_HUMAN	ribosomal protein L15	138					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	7						TTGATCCATTCCATAAAGCTA	0.493000													10	48					0	0	1	0	0
DLEC1	9940	broad.mit.edu	37	3	38163242	38163242	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr3:38163242G>A	ENST00000308059.6	+	35	5011	c.4990G>A	c.(4990-4992)Ggg>Agg	p.G1664R	DLEC1_ENST00000346219.3_Missense_Mutation_p.G1664R|DLEC1_ENST00000452631.2_Missense_Mutation_p.G1667R			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1	1664					negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		GAACCTGAGCGGGTGCCGAAG	0.617000													10	63					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232291	71232291	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr17:71232291C>T	ENST00000359042.2	+	3	864	c.670C>T	c.(670-672)Cct>Tct	p.P224S	C17orf80_ENST00000268942.8_Missense_Mutation_p.P224S|C17orf80_ENST00000426147.2_Missense_Mutation_p.P224S|C17orf80_ENST00000535032.2_Missense_Mutation_p.P224S|C17orf80_ENST00000582793.1_Intron|C17orf80_ENST00000577615.1_Missense_Mutation_p.P224S|FAM104A_ENST00000583178.1_Intron|C17orf80_ENST00000255557.4_Missense_Mutation_p.P224S	NM_017941.4	NP_060411.2	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	224						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			ACTAGATGTGCCTACTGGTGA	0.383000													9	54					0	0	1	0	0
MED12	9968	broad.mit.edu	37	X	70349258	70349258	+	Missense_Mutation	SNP	C	C	T			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chrX:70349258C>T	ENST00000333646.6	+	26	3869	c.3670C>T	c.(3670-3672)Ctc>Ttc	p.L1224F	MED12_ENST00000374102.1_Missense_Mutation_p.L1224F|MED12_ENST00000374080.3_Missense_Mutation_p.L1224F	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1224					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding	p.L1224F(10)|p.V1223>?(2)|p.L1224V(2)		breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					GTTTGCTGTTCTCAAGGCTGT	0.562000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome				OREG0019857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	26					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56515211	56515211	+	Silent	SNP	G	G	C			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr19:56515211G>C	ENST00000390649.3	+	2	192	c.192G>C	c.(190-192)ggG>ggC	p.G64G		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	64	DAPIN.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CCAGCTACGGGCTGCAATGGT	0.428000													17	67					0	0	1	0	0
TAAR6	319100	broad.mit.edu	37	6	132891765	132891765	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr6:132891765G>A	ENST00000275198.1	+	1	305	c.305G>A	c.(304-306)aGg>aAg	p.R102K		NM_175067.1	NP_778237.1	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	102						plasma membrane	G-protein coupled receptor activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(19)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TATTTTGGGAGGAGTTTTTGT	0.493000													23	92					0	0	1	0	0
NCKAP1	10787	broad.mit.edu	37	2	183847593	183847593	+	Silent	SNP	A	A	G			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr2:183847593A>G	ENST00000360982.2	-	13	1940	c.1182T>C	c.(1180-1182)caT>caC	p.H394H	NCKAP1_ENST00000361354.3_Silent_p.H388H	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	388					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGTTATCTGCATGACGAAGTA	0.313000													12	56					0	0	1	0	0
C17orf80	55028	broad.mit.edu	37	17	71232290	71232290	+	Silent	SNP	G	G	T			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr17:71232290G>T	ENST00000359042.2	+	3	863	c.669G>T	c.(667-669)gtG>gtT	p.V223V	C17orf80_ENST00000268942.8_Silent_p.V223V|C17orf80_ENST00000426147.2_Silent_p.V223V|C17orf80_ENST00000535032.2_Silent_p.V223V|C17orf80_ENST00000582793.1_Intron|C17orf80_ENST00000577615.1_Silent_p.V223V|FAM104A_ENST00000583178.1_Intron|C17orf80_ENST00000255557.4_Silent_p.V223V	NM_017941.4	NP_060411.2	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	223						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			TACTAGATGTGCCTACTGGTG	0.388000													9	53					3.86212e-05	4.03004e-05	1	1	0
PCDH18	54510	broad.mit.edu	37	4	138452902	138452902	+	Missense_Mutation	SNP	G	G	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr4:138452902G>A	ENST00000344876.4	-	1	727	c.341C>T	c.(340-342)cCc>cTc	p.P114L	PCDH18_ENST00000510305.1_Intron|PCDH18_ENST00000412923.2_Missense_Mutation_p.P114L|PCDH18_ENST00000507846.1_Intron|PCDH18_ENST00000511115.1_Intron	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	114	Cadherin 1.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					ATGCTCTGTGGGTAGAGTGAT	0.408000													4	136					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72685542	72685542	+	RNA	SNP	G	G	A	rs2539086		TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr7:72685542G>A	ENST00000425256.1	-	0	116					NR_002164.1																						ACGTTACCATGACAAAAGCAG	0.463000													5	130					0	0	1	0	0
SLC38A6	145389	broad.mit.edu	37	14	61503802	61503802	+	Silent	SNP	C	C	T			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr14:61503802C>T	ENST00000354886.2	+	7	672	c.508C>T	c.(508-510)Cta>Tta	p.L170L	SLC38A6_ENST00000456840.2_Silent_p.L147L|SLC38A6_ENST00000267488.4_Silent_p.L170L	NM_001172702.1	NP_001166173.1	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	170					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TGGACAAACACTACTAATAAT	0.358000													6	62					0	0	1	0	0
PAX4	5078	broad.mit.edu	37	7	127253123	127253123	+	Missense_Mutation	SNP	G	G	C			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr7:127253123G>C	ENST00000341640.2	-	6	849	c.644C>G	c.(643-645)gCc>gGc	p.A215G	PAX4_ENST00000378740.2_Missense_Mutation_p.A215G|PAX4_ENST00000463946.1_Missense_Mutation_p.A213G|PAX4_ENST00000338516.3_Missense_Mutation_p.A223G	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	223					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						ACGCCATTTGGCTCTTCTGTT	0.522000													18	44					0	0	1	0	0
ZEB2	9839	broad.mit.edu	37	2	145157536	145157536	+	Silent	SNP	T	T	C			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr2:145157536T>C	ENST00000558170.2	-	8	2402	c.1218A>G	c.(1216-1218)acA>acG	p.T406T	ZEB2_ENST00000409487.3_Silent_p.T406T|ZEB2_ENST00000303660.4_Silent_p.T406T|ZEB2_ENST00000539609.3_Silent_p.T382T	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	406						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		TAAACCCGTGTGTAGCCATAA	0.433000													5	87					0	0	1	0	0
PPP2R3C	55012	broad.mit.edu	37	14	35564292	35564292	+	Missense_Mutation	SNP	G	G	C			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr14:35564292G>C	ENST00000261475.5	-	10	1290	c.937C>G	c.(937-939)Cgt>Ggt	p.R313G		NM_017917.2	NP_060387.2	Q969Q6	P2R3C_HUMAN	protein phosphatase 2, regulatory subunit B'', gamma	313						centrosome|nucleus	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)	15	Breast(36;0.0545)|Hepatocellular(127;0.158)|Prostate(35;0.184)		Lung(238;8.62e-06)|LUAD - Lung adenocarcinoma(48;1.42e-05)|Epithelial(34;0.0177)|all cancers(34;0.0491)	GBM - Glioblastoma multiforme(112;0.0803)		TGGAAAACACGGTCTAAGAAG	0.413000													8	42					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161618	90161618	+	RNA	SNP	C	C	T	rs13338202	by1000genomes	TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr16:90161618C>T	ENST00000564451.1	+	0	971				TUBB8P7_ENST00000567960.1_RNA														p.D118D(2)									CAGTGATGGACGTTGTCAGAA	0.607000													4	28					0	0	1	0	0
GPR83	10888	broad.mit.edu	37	11	94113908	94113908	+	Missense_Mutation	SNP	C	C	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr11:94113908C>A	ENST00000243673.2	-	4	850	c.679G>T	c.(679-681)Gac>Tac	p.D227Y	GPR83_ENST00000539203.2_Missense_Mutation_p.D185Y	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	227						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TCAGGGAAGTCTGGCAGGCAG	0.567000													12	36					4.93089e-13	5.37915e-13	1	1	0
VPS28	51160	broad.mit.edu	37	8	145649503	145649503	+	Silent	SNP	G	G	A			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr8:145649503G>A	ENST00000377348.2	-	9	558	c.469C>T	c.(469-471)Ctg>Ttg	p.L157L	VPS28_ENST00000292510.4_Silent_p.L157L|VPS28_ENST00000526054.1_Silent_p.L157L|VPS28_ENST00000529182.1_Silent_p.L157L	NM_183057.1	NP_898880.1	Q9UK41	VPS28_HUMAN	vacuolar protein sorting 28 homolog (S. cerevisiae)	157	VPS28 C-terminal.				cellular membrane organization|endosome transport|negative regulation of protein ubiquitination|protein transport	cytosol|late endosome membrane|plasma membrane	protein binding			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			AGCTCTCGCAGGTCGGGCTGG	0.677000													3	54					0	0	1	0	0
FAM188B	84182	broad.mit.edu	37	7	30818114	30818114	+	Missense_Mutation	SNP	A	A	G			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr7:30818114A>G	ENST00000265299.6	+	2	207	c.130A>G	c.(130-132)Aga>Gga	p.R44G	INMT-FAM188B_ENST00000458257.1_3'UTR	NM_032222.2	NP_115598.2	Q4G0A6	F188B_HUMAN	family with sequence similarity 188, member B	44										endometrium(1)|large_intestine(5)|lung(19)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CATAAACAACAGAAATGATCT	0.448000													17	61					0	0	1	0	0
FAM107B	83641	broad.mit.edu	37	10	14563937	14563938	+	Frame_Shift_Ins	INS	-	-	G			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr10:14563937_14563938insG	ENST00000181796.2	-	4	967_968	c.734_735insC	c.(733-735)ggafs	p.G245fs	FAM107B_ENST00000378465.3_Frame_Shift_Ins_p.G70fs|FAM107B_ENST00000378470.1_Frame_Shift_Ins_p.G70fs|FAM107B_ENST00000378467.4_Frame_Shift_Ins_p.G70fs|FAM107B_ENST00000378462.1_Frame_Shift_Ins_p.G70fs|FAM107B_ENST00000468747.1_Frame_Shift_Ins_p.G70fs|FAM107B_ENST00000479731.1_Frame_Shift_Ins_p.G70fs|FAM107B_ENST00000378458.2_Frame_Shift_Ins_p.G70fs|FAM107B_ENST00000478076.1_Frame_Shift_Ins_p.G70fs|FAM107B_ENST00000496330.1_Frame_Shift_Ins_p.G70fs	NM_031453.2	NP_113641.2	Q9H098	F107B_HUMAN	family with sequence similarity 107, member B	70										breast(7)|kidney(1)|large_intestine(4)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GTGCTTCTTCTTCCTTCTGCTT	0.426													25	73	---	---	---	---					
CPXM2	119587	broad.mit.edu	37	10	125528165	125528167	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr10:125528165_125528167delCAG	ENST00000241305.3	-	9	1328_1330	c.1174_1176delCTG	c.(1174-1176)del	p.L392del	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	392	Poly-Leu.				cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CGAACTGCACCAGCAGCAGCAGC	0.626													7	174	---	---	---	---					
ABCA10	10349	broad.mit.edu	37	17	67210954	67210959	+	In_Frame_Del	DEL	AAAAAT	AAAAAT	-			TCGA-KC-A7F3-01A-21D-A33T-08	TCGA-KC-A7F3-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bcdd04ee-ff3e-4fa3-8115-4c94b0af9170	45a165ad-d560-4ed7-87ac-056436c3d192	g.chr17:67210954_67210959delAAAAAT	ENST00000269081.4	-	10	1801_1806	c.892_897delATTTTT	c.(892-897)del	p.IF298del	ABCA10_ENST00000432313.2_In_Frame_Del_p.IF298del|ABCA10_ENST00000416101.2_In_Frame_Del_p.IF298del	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	298					transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					AGGGATCAGGAAAAATAACACCACTT	0.267													11	57	---	---	---	---