Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KRTAP4-6	81871	broad.mit.edu	37	17	39296282	39296282	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr17:39296282G>T	ENST00000345847.4	-	1	457	c.458C>A	c.(457-459)tCt>tAt	p.S153Y		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	149	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						ttcacagcaagaggggcggca	0.662000													3	24					0.115264	0.116934	1	1	0
HIST1H3G	8355	broad.mit.edu	37	6	26271485	26271485	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr6:26271485C>A	ENST00000305910.3	-	1	127	c.128G>T	c.(127-129)cGt>cTt	p.R43L		NM_003534.2	NP_003525.1	P68431	H31_HUMAN	histone cluster 1, H3g	43					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12						GGTGCCGGGACGGTAGCGATG	0.637000													6	106					0.0215528	0.0221867	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141607757	141607757	+	Missense_Mutation	SNP	T	T	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr2:141607757T>A	ENST00000389484.3	-	29	5824	c.4853A>T	c.(4852-4854)gAa>gTa	p.E1618V		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1618					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTATAAACGTTCCTCAGATGC	0.363000										TSP Lung(27;0.18)			7	65					0	0	1	0	0
CDC20B	166979	broad.mit.edu	37	5	54420671	54420671	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr5:54420671C>T	ENST00000296733.1	-	9	1349	c.1175G>A	c.(1174-1176)gGc>gAc	p.G392D	CDC20B_ENST00000334206.5_3'UTR|CDC20B_ENST00000381375.2_Missense_Mutation_p.G392D|CDC20B_ENST00000322374.6_Missense_Mutation_p.G392D	NM_001170402.1|NM_152623.2	NP_001163873.1|NP_689836.2	Q86Y33	CD20B_HUMAN	cell division cycle 20B	392										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			CAGCGGTTGGCCCTGTGCACT	0.537000													4	84					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121206355	121206355	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr3:121206355A>G	ENST00000264233.5	-	16	5551	c.5423T>C	c.(5422-5424)tTa>tCa	p.L1808S		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1808					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		ATCCTGTGATAACTGAAGTGA	0.388000								DNA polymerases (catalytic subunits)					8	106					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238274427	238274427	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr2:238274427G>A	ENST00000295550.4	-	12	6204	c.5752C>T	c.(5752-5754)Cgc>Tgc	p.R1918C	COL6A3_ENST00000472056.1_Missense_Mutation_p.R1311C|COL6A3_ENST00000409809.1_Missense_Mutation_p.R1712C|COL6A3_ENST00000353578.4_Missense_Mutation_p.R1712C|COL6A3_ENST00000347401.3_Missense_Mutation_p.R1717C|COL6A3_ENST00000346358.4_Missense_Mutation_p.R1718C	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1918	Nonhelical region.|VWFA 10.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TGCTGGCTGCGCATGTTCCGG	0.617000													6	112					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													4	76					0	0	1	0	0
HIPK3	10114	broad.mit.edu	37	11	33308014	33308014	+	Silent	SNP	T	T	C			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr11:33308014T>C	ENST00000303296.4	+	2	359	c.54T>C	c.(52-54)agT>agC	p.S18S	HIPK3_ENST00000525975.1_Silent_p.S18S|HIPK3_ENST00000379016.3_Silent_p.S18S|HIPK3_ENST00000456517.1_Silent_p.S18S	NM_005734.3	NP_005725.3	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3	18					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			endometrium(3)|kidney(3)|large_intestine(9)|liver(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	39						CTCAGTCAAGTGCCTTTTGTA	0.373000													3	36					0	0	1	0	0
ZNF883	169834	broad.mit.edu	37	9	115759947	115759947	+	RNA	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr9:115759947C>T	ENST00000427548.1	-	0	1866							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										TCTCTGATGTCGGATTAGTGA	0.408000													19	49					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458702	45458702	+	RNA	SNP	G	G	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr12:45458702G>T	ENST00000548424.1	+	0	448																											CAGATTCATCGCTAATTTAAA	0.438000													11	23					4.68919e-08	5.1288e-08	1	1	0
BTN2A3P	0	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													5	178					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13724865	13724865	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr12:13724865G>A	ENST00000279593.3	-	10	2253	c.2044C>T	c.(2044-2046)Cgc>Tgc	p.R682C		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	682					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTCCCAAAGCGGAAAGGGGGT	0.488000													4	36					0	0	1	0	0
FAM198B	51313	broad.mit.edu	37	4	159092350	159092350	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr4:159092350G>A	ENST00000296530.8	-	2	799	c.178C>T	c.(178-180)Ctc>Ttc	p.L60F	FAM198B_ENST00000592057.1_Missense_Mutation_p.L60F|RP11-597D13.9_ENST00000503611.1_RNA|FAM198B_ENST00000585682.1_Missense_Mutation_p.L60F|FAM198B_ENST00000393807.5_Missense_Mutation_p.L60F|FAM198B_ENST00000589306.1_Intron	NM_016613.6	NP_057697.2	Q6UWH4	F198B_HUMAN	family with sequence similarity 198, member B	60						Golgi membrane|integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(14)|skin(2)|urinary_tract(1)	26						CCATGCTGGAGAGAGGCCCTC	0.662000													6	101					0	0	1	0	0
RAB13	5872	broad.mit.edu	37	1	153958656	153958656	+	Silent	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr1:153958656C>T	ENST00000368575.3	-	1	172	c.57G>A	c.(55-57)gtG>gtA	p.V19V	RAB13_ENST00000462680.1_5'UTR	NM_002870.2	NP_002861.1	P51153	RAB13_HUMAN	RAB13, member RAS oncogene family	19					cell adhesion|protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	cytoplasmic vesicle membrane|tight junction	GTP binding|GTPase activity			breast(1)|endometrium(3)|kidney(1)|lung(5)|urinary_tract(1)	11	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AAGTCTTGCCCACCCCCGAGT	0.627000													8	26					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185939492	185939492	+	Silent	SNP	A	A	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr1:185939492A>T	ENST00000271588.4	+	15	2467	c.2238A>T	c.(2236-2238)acA>acT	p.T746T	HMCN1_ENST00000367492.2_Silent_p.T746T|HMCN1_ENST00000485744.1_3'UTR	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	746	Ig-like C2-type 4.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GGCCCTCAACATTCCTCATTA	0.383000													7	177					0	0	1	0	0
MPEG1	219972	broad.mit.edu	37	11	58979777	58979777	+	Silent	SNP	T	T	G			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr11:58979777T>G	ENST00000361050.3	-	1	647	c.562A>C	c.(562-564)Agg>Cgg	p.R188R		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	188	MACPF.					integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				GTGGCCATCCTCGTCTGGTTG	0.527000													8	105					0	0	1	0	0
ITGB8	3696	broad.mit.edu	37	7	20444317	20444317	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr7:20444317G>A	ENST00000222573.3	+	11	2438	c.1754G>A	c.(1753-1755)tGc>tAc	p.C585Y	ITGB8_ENST00000537992.1_Missense_Mutation_p.C450Y	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	585	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						CGATGCCAGTGCCCTTCAGCA	0.562000													5	47					0	0	1	0	0
PAN2	9924	broad.mit.edu	37	12	56711419	56711419	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr12:56711419C>T	ENST00000425394.2	-	26	3959	c.3583G>A	c.(3583-3585)Gtc>Atc	p.V1195I	PAN2_ENST00000257931.5_Missense_Mutation_p.V1194I|PAN2_ENST00000549090.1_5'UTR|PAN2_ENST00000548043.1_Missense_Mutation_p.V1195I|PAN2_ENST00000440411.3_Missense_Mutation_p.V1191I	NM_001127460.2	NP_001120932.1	Q504Q3	PAN2_HUMAN	PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	1195					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						GAGGAGAAGACAGCTGCATCT	0.463000													5	49					0	0	1	0	0
MCPH1	79648	broad.mit.edu	37	8	6312713	6312713	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr8:6312713C>G	ENST00000344683.5	+	9	1951	c.1875C>G	c.(1873-1875)gaC>gaG	p.D625E		NM_024596.3	NP_078872.2	Q8NEM0	MCPH1_HUMAN	microcephalin 1	625						microtubule organizing center			AGPAT5/MCPH1(2)	central_nervous_system(1)|large_intestine(4)|skin(1)	6		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		ACTCATGTGACGGCTTTAAGG	0.348000													8	98					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	14412372	14412372	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr8:14412372G>T	ENST00000382080.1	-	2	818	c.103C>A	c.(103-105)Caa>Aaa	p.Q35K	SGCZ_ENST00000421524.2_Missense_Mutation_p.Q22K	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	22					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		GGGTAAAGTTGTGCATTCTCA	0.388000													7	185					0.307466	0.307466	1	1	0
MYL6B	140465	broad.mit.edu	37	12	56549344	56549344	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr12:56549344G>C	ENST00000553066.1	+	5	910	c.488G>C	c.(487-489)gGa>gCa	p.G163A	MYL6B_ENST00000550152.1_3'UTR|MYL6B_ENST00000550443.1_Missense_Mutation_p.G163A|MYL6B_ENST00000552568.1_Intron|RP11-603J24.14_ENST00000548731.1_RNA|MYL6B_ENST00000207437.5_Missense_Mutation_p.G163A			P14649	MYL6B_HUMAN	myosin, light chain 6B, alkali, smooth muscle and non-muscle	163	EF-hand 2.				muscle filament sliding|skeletal muscle tissue development	cytosol|muscle myosin complex|unconventional myosin complex	calcium ion binding|motor activity|protein binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(4)	7			OV - Ovarian serous cystadenocarcinoma(18;0.0979)			AAAGTCATGGGAGCAGAGCTC	0.567000													9	161					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296254	39296254	+	Silent	SNP	C	C	G	rs72483263	by1000genomes	TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr17:39296254C>G	ENST00000345847.4	-	1	485	c.486G>C	c.(484-486)ccG>ccC	p.P162P		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	158	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						ggcagcagcacgggcggcagc	0.662000													3	18					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64909076	64909076	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr14:64909076G>T	ENST00000555709.1	+	21	2479	c.2092G>T	c.(2092-2094)Gtt>Ttt	p.V698F	MTHFD1_ENST00000216605.7_Missense_Mutation_p.V754F|CTD-2555O16.2_ENST00000556640.1_RNA|MTHFD1_ENST00000545908.1_Missense_Mutation_p.V754F	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	698	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GGTGGTGCTTGTTGCCACTGT	0.537000													4	89					0.00024832	0.000267422	1	1	0
ZNF519	162655	broad.mit.edu	37	18	14105529	14105529	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr18:14105529T>C	ENST00000590202.1	-	3	1162	c.1010A>G	c.(1009-1011)cAa>cGa	p.Q337R	ZNF519_ENST00000589203.1_Intron|ZNF519_ENST00000589498.1_Intron	NM_145287.3	NP_660330.2	Q8TB69	ZN519_HUMAN	zinc finger protein 519	337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	18						TCTCTGATGTTGAGTAAGGTA	0.428000													10	132					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57181784	57181784	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr4:57181784C>T	ENST00000504228.1	+	6	2221	c.2116C>T	c.(2116-2118)Cgc>Tgc	p.R706C	KIAA1211_ENST00000264229.6_Missense_Mutation_p.R706C|KIAA1211_ENST00000541073.1_Missense_Mutation_p.R699C			Q6ZU35	K1211_HUMAN	KIAA1211	706										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					GTGTGATTCCCGCGGGAACCA	0.582000													20	146					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75985564	75985564	+	Silent	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr15:75985564G>A	ENST00000308508.5	-	2	191	c.99C>T	c.(97-99)ttC>ttT	p.F33F		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	33	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 1.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GGTTCTCACCGAAGAAGGAAG	0.617000													7	24					0	0	1	0	0
ADIPOR2	79602	broad.mit.edu	37	12	1889767	1889767	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr12:1889767A>G	ENST00000357103.4	+	5	865	c.614A>G	c.(613-615)tAc>tGc	p.Y205C		NM_024551.2	NP_078827.2	Q86V24	ADR2_HUMAN	adiponectin receptor 2	205					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane	hormone binding|receptor activity			endometrium(1)|large_intestine(3)|lung(7)|stomach(1)	12	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000382)			CACACAGTCTACTGCCACTCA	0.448000													15	158					0	0	1	0	0
GLG1	2734	broad.mit.edu	37	16	74490581	74490581	+	Missense_Mutation	SNP	T	T	C	rs144493700	byFrequency	TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr16:74490581T>C	ENST00000422840.2	-	25	3337	c.3338A>G	c.(3337-3339)aAt>aGt	p.N1113S	GLG1_ENST00000447066.2_Missense_Mutation_p.N1102S|GLG1_ENST00000205061.5_Missense_Mutation_p.N1113S	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1	1113						Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						AATCCGGTCATTGAGGCGCTT	0.418000													23	112					0	0	1	0	0
SPATA2	9825	broad.mit.edu	37	20	48525010	48525010	+	Silent	SNP	T	T	G			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr20:48525010T>G	ENST00000422556.1	-	2	367	c.18A>C	c.(16-18)tcA>tcC	p.S6S	SPATA2_ENST00000543716.1_Intron|SPATA2_ENST00000289431.5_Silent_p.S6S	NM_001135773.1	NP_001129245.1	Q9UM82	SPAT2_HUMAN	spermatogenesis associated 2	6					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|nucleus				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	20	Hepatocellular(150;0.133)		BRCA - Breast invasive adenocarcinoma(9;4.03e-06)			TAGTATCCATTGAACTGGGCT	0.522000													5	51					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112089	57112089	+	Silent	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr12:57112089G>A	ENST00000454682.1	-	3	3506	c.3225C>T	c.(3223-3225)tcC>tcT	p.S1075S	NACA_ENST00000356769.3_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000550952.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000551793.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CCCCCTTGAGGGATGGGGTAG	0.667000			T	BCL6	NHL								5	115					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88956732	88956732	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr7:88956732A>C	ENST00000333190.4	+	3	933	c.324A>C	c.(322-324)caA>caC	p.Q108H		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	108						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGAAAAAACAAGAAAAAGCAC	0.373000										HNSCC(36;0.09)			4	70					0	0	1	0	0
DMPK	1760	broad.mit.edu	37	19	46281067	46281067	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr19:46281067C>T	ENST00000600757.1	-	6	1457	c.770G>A	c.(769-771)gGc>gAc	p.G257D	DMPK_ENST00000354227.5_Missense_Mutation_p.G247D|DMPK_ENST00000343373.4_Missense_Mutation_p.G257D|DMPK_ENST00000447742.2_Missense_Mutation_p.G247D|DMPK_ENST00000458663.2_Missense_Mutation_p.G247D|DMPK_ENST00000291270.4_Missense_Mutation_p.G247D			Q09013	DMPK_HUMAN	dystrophia myotonica-protein kinase	257	Protein kinase.				regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(5)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)|urinary_tract(2)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		AGGCCCACCGCCCACAGCCTG	0.652000													8	161					0	0	1	0	0
SLC2A14	144195	broad.mit.edu	37	12	7967015	7967015	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr12:7967015C>T	ENST00000543909.1	-	16	2219	c.1460G>A	c.(1459-1461)cGg>cAg	p.R487Q	SLC2A14_ENST00000396589.2_Missense_Mutation_p.R487Q|SLC2A14_ENST00000431042.2_Missense_Mutation_p.R464Q|SLC2A14_ENST00000539924.1_Missense_Mutation_p.R502Q|SLC2A14_ENST00000535295.1_Missense_Mutation_p.R378Q|SLC2A14_ENST00000542546.1_Missense_Mutation_p.R378Q|SLC2A14_ENST00000542505.1_Missense_Mutation_p.R128Q|SLC2A14_ENST00000340749.5_Missense_Mutation_p.R464Q			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14	487					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		TTCAAAGGCCCGTGTGATATC	0.517000													4	159					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49416433	49416433	+	Nonsense_Mutation	SNP	G	G	C			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr12:49416433G>C	ENST00000301067.7	-	51	16277	c.16278C>G	c.(16276-16278)taC>taG	p.Y5426*		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TGGTGCCAATGTACTCGATAA	0.552000													55	239					0	0	1	0	0
P4HA2	8974	broad.mit.edu	37	5	131544974	131544974	+	Silent	SNP	A	A	G	rs148453847	by1000genomes	TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr5:131544974A>G	ENST00000401867.1	-	8	1328	c.760T>C	c.(760-762)Ttg>Ctg	p.L254L	P4HA2_ENST00000379104.2_Silent_p.L254L|P4HA2_ENST00000379086.1_Silent_p.L254L|P4HA2_ENST00000379100.2_Silent_p.L254L|P4HA2_ENST00000360568.3_Silent_p.L254L|P4HA2_ENST00000166534.4_Silent_p.L254L			O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha polypeptide II	254						endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	TCTTCCTCCAATAACTGCTCA	0.468000													7	231					0	0	1	0	0
IL17RA	23765	broad.mit.edu	37	22	17589607	17589607	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr22:17589607G>A	ENST00000319363.6	+	13	1631	c.1498G>A	c.(1498-1500)Gta>Ata	p.V500I		NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	500	SEFIR.				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		CGGCACCTACGTAGTCTGCTA	0.642000													4	28					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207818584	207818584	+	Silent	SNP	G	G	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr1:207818584G>T	ENST00000508064.2	+	1	66	c.6G>T	c.(4-6)gcG>gcT	p.A2A		NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	2						cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CGCTCATGGCGCCTCCCGTCC	0.637000													5	88					0.000602214	0.000638712	1	1	0
LILRB1	0	broad.mit.edu	37	19	55143586	55143586	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr19:55143586G>A	ENST00000396331.1	+	6	916	c.559G>A	c.(559-561)Gtg>Atg	p.V187M	LILRB1_ENST00000396332.4_Missense_Mutation_p.V187M|LILRB1_ENST00000448689.1_Missense_Mutation_p.V187M|LILRB1_ENST00000434867.2_Missense_Mutation_p.V187M|LILRB1_ENST00000324602.7_Missense_Mutation_p.V187M|LILRB1_ENST00000396317.1_Missense_Mutation_p.V187M|LILRB1_ENST00000396327.3_Missense_Mutation_p.V187M|LILRB1_ENST00000427581.2_Missense_Mutation_p.V223M|LILRB1_ENST00000396315.1_Missense_Mutation_p.V187M|LILRB1_ENST00000418536.2_Missense_Mutation_p.V187M|LILRB1_ENST00000396321.2_Missense_Mutation_p.V187M	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	187	Ig-like C2-type 2.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CGTGGGCCCCGTGAGCCCGAG	0.587000										HNSCC(37;0.09)			4	201					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	732477	732477	+	Silent	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr9:732477G>A	ENST00000382303.1	+	10	3757	c.3105G>A	c.(3103-3105)gaG>gaA	p.E1035E	KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382297.2_Silent_p.E1035E|KANK1_ENST00000382293.3_Silent_p.E877E	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	1035					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TTGAAGAAGAGGAGGAGGAGG	0.468000													4	131					0	0	1	0	0
PRTFDC1	56952	broad.mit.edu	37	10	25160959	25160959	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr10:25160959C>T	ENST00000320152.6	-	4	401	c.373G>A	c.(373-375)Gga>Aga	p.G125R	PRTFDC1_ENST00000376378.1_Missense_Mutation_p.G125R	NM_020200.5	NP_064585.1	Q9NRG1	PRDC1_HUMAN	phosphoribosyl transferase domain containing 1	125					adenine salvage|central nervous system neuron development|cerebral cortex neuron differentiation|cytolysis|dendrite morphogenesis|GMP salvage|grooming behavior|hypoxanthine metabolic process|IMP salvage|lymphocyte proliferation|positive regulation of dopamine metabolic process|purine ribonucleoside salvage|response to amphetamine|striatum development	cytosol	hypoxanthine phosphoribosyltransferase activity|magnesium ion binding|nucleotide binding|protein homodimerization activity	p.G125R(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	9						TCATCGCCTCCGATTATCTGC	0.453000													11	314					0	0	1	0	0
PROSER1	80209	broad.mit.edu	37	13	39586310	39586310	+	Silent	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr13:39586310C>T	ENST00000352251.3	-	12	3455	c.2622G>A	c.(2620-2622)ccG>ccA	p.P874P	PROSER1_ENST00000484434.2_5'UTR|PROSER1_ENST00000350125.3_Silent_p.P852P	NM_025138.3	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	874								p.P874P(1)									CAGGGATACCCGGGAGGGACA	0.453000													18	278					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1065403	1065403	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr5:1065403A>G	ENST00000264930.5	-	18	2475	c.2432T>C	c.(2431-2433)tTt>tCt	p.F811S		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	811					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CCTACCCACAAAGTTCTTCCA	0.642000													5	94					0	0	1	0	0
ANKRD36BP2	0	broad.mit.edu	37	2	89084114	89084114	+	RNA	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr2:89084114G>A	ENST00000393525.3	+	0	576																											TTGCTTTTCAGTGTCTTCTCA	0.313000													7	62					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38511002	38511002	+	Silent	SNP	A	A	C			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr21:38511002A>C	ENST00000399017.2	+	19	4394	c.1647A>C	c.(1645-1647)atA>atC	p.I549I	TTC3_ENST00000355666.1_Silent_p.I549I|TTC3_ENST00000354749.2_Silent_p.I549I|TTC3_ENST00000540756.1_Silent_p.I239I|TTC3_ENST00000479930.1_3'UTR	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	549					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				TCCTTGGAATAGGACAGCCTG	0.323000													5	120					0	0	1	0	0
FDXACB1	91893	broad.mit.edu	37	11	111745901	111745901	+	Silent	SNP	A	A	G			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr11:111745901A>G	ENST00000260257.4	-	5	1667	c.1620T>C	c.(1618-1620)gtT>gtC	p.V540V	FDXACB1_ENST00000542429.1_Silent_p.V391V|ALG9_ENST00000527377.1_Intron|ALG9_ENST00000524880.1_Intron	NM_138378.2	NP_612387.1	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain containing 1	540	FDX-ACB.				phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(3)	19						TCCAAAAACTAACATCATGCA	0.383000													3	47					0	0	1	0	0
GAD2	2572	broad.mit.edu	37	10	26505785	26505785	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr10:26505785G>A	ENST00000376261.3	+	1	550	c.47G>A	c.(46-48)gGc>gAc	p.G16D	GAD2_ENST00000259271.3_Missense_Mutation_p.G16D	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	16					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	TCGGAAGATGGCTCTGGGGAT	0.637000													7	115					0	0	1	0	0
GNRHR	0	broad.mit.edu	37	4	68619905	68619905	+	Missense_Mutation	SNP	G	G	A	rs150422225		TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr4:68619905G>A	ENST00000226413.4	-	1	173	c.149C>T	c.(148-150)gCg>gTg	p.A50V	RP11-453E17.1_ENST00000500538.2_RNA|GNRHR_ENST00000420975.2_Missense_Mutation_p.A50V|RP11-453E17.1_ENST00000502758.1_RNA	NM_000406.2	NP_000397.1	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor	50					multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	13					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	ATTAAAGGTCGCAGAGAGCAG	0.443000													28	106					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48218517	48218517	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr16:48218517G>A	ENST00000394747.1	-	22	3441	c.3092C>T	c.(3091-3093)gCg>gTg	p.A1031V	ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000356608.2_Missense_Mutation_p.A1031V|ABCC11_ENST00000394748.1_Missense_Mutation_p.A1031V|ABCC11_ENST00000353782.5_Missense_Mutation_p.A1031V	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1031	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GTTATTCTGCGCATCAGTCAG	0.507000													6	106					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26455034	26455034	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr10:26455034G>A	ENST00000265944.5	+	27	3204	c.3038G>A	c.(3037-3039)cGc>cAc	p.R1013H	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1013	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity	p.R1013H(1)		NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						GAGGAGCCCCGCATGAGCCCT	0.448000													5	273					0	0	1	0	0
FMNL3	91010	broad.mit.edu	37	12	50041125	50041125	+	Silent	SNP	G	G	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr12:50041125G>T	ENST00000335154.5	-	24	3038	c.2805C>A	c.(2803-2805)cgC>cgA	p.R935R	FMNL3_ENST00000550488.1_Silent_p.R934R|FMNL3_ENST00000352151.5_Silent_p.R884R|FMNL3_ENST00000293590.5_Silent_p.R935R	NM_175736.4	NP_783863.4	Q8IVF7	FMNL3_HUMAN	formin-like 3	935	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|stomach(1)	39						CCTGCTTCTTGCGGGCTTCAT	0.597000													8	114					0.00448238	0.00468308	1	1	0
ZAN	7455	broad.mit.edu	37	7	100363150	100363150	+	RNA	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr7:100363150C>T	ENST00000542585.1	+	0	4591				ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AGTGTGGGTGCCTCCACCCTG	0.637000													4	16					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186275982	186275982	+	Silent	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr1:186275982C>T	ENST00000445192.2	+	7	1176	c.1131C>T	c.(1129-1131)acC>acT	p.T377T	PRG4_ENST00000367483.4_Silent_p.T336T|PRG4_ENST00000367485.4_Silent_p.T284T|PRG4_ENST00000367484.3_Silent_p.T336T|PRG4_ENST00000367486.3_Silent_p.T334T	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	377	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CACCCACCACCCCCAAGGAGC	0.637000													5	231					0	0	1	0	0
PYGL	5836	broad.mit.edu	37	14	51372228	51372228	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr14:51372228G>A	ENST00000216392.7	-	20	2758	c.2426C>T	c.(2425-2427)tCg>tTg	p.S809L	PYGL_ENST00000544180.2_Missense_Mutation_p.S775L|PYGL_ENST00000532462.1_Intron	NM_002863.4	NP_002854.3	P06737	PYGL_HUMAN	phosphorylase, glycogen, liver	809					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(3)	25	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	GAATTTCCCCGAGGCAGCTAT	0.423000													13	108					0	0	1	0	0
MCHR2	84539	broad.mit.edu	37	6	100390958	100390958	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr6:100390958G>A	ENST00000281806.2	-	4	768	c.454C>T	c.(454-456)Cgg>Tgg	p.R152W	MCHR2_ENST00000445970.1_Missense_Mutation_p.R152W|MCHR2_ENST00000369212.1_Missense_Mutation_p.R152W	NM_001040179.1	NP_001035269.1	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	152			R -> Q (no changes in receptor binding or functional signaling).			integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	39		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		AAATTGATCCGGATGGTCTTG	0.473000													9	133					0	0	1	0	0
PLSCR5	389158	broad.mit.edu	37	3	146311885	146311885	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr3:146311885T>C	ENST00000443512.1	-	4	1278	c.275A>G	c.(274-276)aAc>aGc	p.N92S	PLSCR5_ENST00000492200.1_Missense_Mutation_p.N92S|PLSCR5_ENST00000482567.1_Missense_Mutation_p.N80S	NM_001085420.1	NP_001078889.1	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	92										endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						TCCCAAGCTGTTTTTAATCTC	0.348000													25	117					0	0	1	0	0
TUBBP5	0	broad.mit.edu	37	9	141070783	141070783	+	RNA	SNP	G	G	C	rs28412015		TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr9:141070783G>C	ENST00000503395.1	+	0	1558																											AGGGTTTCCAGCTGACCCACT	0.592000													6	22					0	0	1	0	0
CCDC144NL	339184	broad.mit.edu	37	17	20799125	20799125	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr17:20799125T>C	ENST00000327925.5	-	1	328	c.209A>G	c.(208-210)gAc>gGc	p.D70G	RP11-344E13.3_ENST00000417232.2_RNA|RP11-344E13.3_ENST00000577537.1_RNA|RP11-344E13.3_ENST00000582324.1_RNA|RP11-344E13.3_ENST00000577860.1_RNA|RP11-344E13.3_ENST00000583962.1_RNA|RP11-344E13.3_ENST00000439794.2_RNA	NM_001004306.1	NP_001004306.1	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family, N-terminal like	70										large_intestine(3)|lung(3)|skin(1)	7						CTGGAGCTGGTCTAAGGCGCC	0.642000													7	191					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38592968	38592968	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr3:38592968C>T	ENST00000413689.1	-	28	5088	c.4895G>A	c.(4894-4896)cGc>cAc	p.R1632H	SCN5A_ENST00000443581.1_Missense_Mutation_p.R1631H|SCN5A_ENST00000423572.2_Missense_Mutation_p.R1631H|SCN5A_ENST00000414099.2_Missense_Mutation_p.R1614H|SCN5A_ENST00000451551.2_Missense_Mutation_p.R1578H|SCN5A_ENST00000333535.4_Missense_Mutation_p.R1632H|SCN5A_ENST00000455624.2_Missense_Mutation_p.R1599H|SCN5A_ENST00000450102.2_Missense_Mutation_p.R1578H|SCN5A_ENST00000449557.2_Missense_Mutation_p.R1578H|SCN5A_ENST00000425664.1_Missense_Mutation_p.R1614H	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1632					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCTGAGGATGCGGCCTATTCG	0.592000													4	159					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121192246	121192246	+	Missense_Mutation	SNP	A	A	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr3:121192246A>T	ENST00000264233.5	-	21	6622	c.6494T>A	c.(6493-6495)aTt>aAt	p.I2165N		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	2165					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TCCATTGTCAATCCCTCTTCT	0.443000								DNA polymerases (catalytic subunits)					20	231					0	0	1	0	0
CDH24	64403	broad.mit.edu	37	14	23524544	23524544	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr14:23524544G>A	ENST00000397359.3	-	3	479	c.220C>T	c.(220-222)Cgg>Tgg	p.R74W	CDH24_ENST00000554034.1_Missense_Mutation_p.R74W|CDH24_ENST00000267383.5_Missense_Mutation_p.R74W|CDH24_ENST00000487137.2_Missense_Mutation_p.R74W	NM_022478.3	NP_071923.2	Q86UP0	CAD24_HUMAN	cadherin 24, type 2	74	Cadherin 1.				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CCCTCTCCCCGGTCAACATCC	0.557000											OREG0022594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	75					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100677621	100677621	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr7:100677621C>A	ENST00000306151.4	+	3	2988	c.2924C>A	c.(2923-2925)aCc>aAc	p.T975N		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	975	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCATACCAACCTCGACTCCT	0.502000													29	972					1.55469e-16	1.72744e-16	1	1	0
AC019118.2	0	broad.mit.edu	37	2	2910722	2910723	+	RNA	INS	-	-	T			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr2:2910722_2910723insT	ENST00000457478.1	-	0	594																											tccaccccctctccccagccca	0.708													2	4	---	---	---	---					
TMEM184C	55751	broad.mit.edu	37	4	148555575	148555575	+	Frame_Shift_Del	DEL	T	T	-			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr4:148555575delT	ENST00000296582.3	+	10	1881	c.1307delT	c.(1306-1308)ggfs	p.V436fs	TMEM184C_ENST00000508208.1_Intron	NM_018241.2	NP_060711.2	Q9NVA4	T184C_HUMAN	transmembrane protein 184C	436						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(2)|prostate(1)	16						GATAAATCCGTGGATTCCTGA	0.398													9	76	---	---	---	---					
MEST	4232	broad.mit.edu	37	7	130143791	130143791	+	Frame_Shift_Del	DEL	C	C	-			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr7:130143791delC	ENST00000223215.4	+	11	1065	c.844delC	c.(844-846)cafs	p.P282fs	MEST_ENST00000378576.4_Frame_Shift_Del_p.P239fs|MEST_ENST00000416162.2_Frame_Shift_Del_p.P239fs|MEST_ENST00000437945.1_Intron|MEST_ENST00000393187.1_Frame_Shift_Del_p.P273fs|MEST_ENST00000341441.4_Frame_Shift_Del_p.P273fs	NM_001253900.1|NM_002402.3	NP_001240829.1|NP_002393.2	Q5EB52	MEST_HUMAN	mesoderm specific transcript	282					mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(2)	12	Melanoma(18;0.0435)					TATCTATGGGCCATTGGATCC	0.408													11	80	---	---	---	---					
RP11-551L14.1	0	broad.mit.edu	37	12	31269189	31269190	+	RNA	INS	-	-	ATCAT	rs35880498		TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr12:31269189_31269190insATCAT	ENST00000542490.1	-	0	165																				central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(25)|prostate(3)|stomach(3)|urinary_tract(1)	41						CATGAGAACTCATTACCATGAT	0.351													4	8	---	---	---	---					
ESRRAP2	0	broad.mit.edu	37	13	21835723	21835728	+	RNA	DEL	GGCGAG	GGCGAG	-			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr13:21835723_21835728delGGCGAG	ENST00000427890.1	+	0	61																											GATGGACTGAGGCGAGGGGTGGGACT	0.646													2	4	---	---	---	---					
SNHG14	0	broad.mit.edu	37	15	25434470	25434470	+	RNA	DEL	C	C	-			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr15:25434470delC	ENST00000424208.1	+	0	906				SNHG14_ENST00000414175.1_RNA	NR_003305.1																						TCAGGCTCTTCCTGGCGCCCT	0.612													19	126	---	---	---	---					
VN1R2	317701	broad.mit.edu	37	19	53762385	53762385	+	Frame_Shift_Del	DEL	C	C	-			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr19:53762385delC	ENST00000341702.3	+	1	841	c.757delC	c.(757-759)ttfs	p.L253fs		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	253					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		TTCTGCCCCACTTAGTGATGA	0.433													10	159	---	---	---	---					
TMPRSS2	0	broad.mit.edu	37	21	42843790	42843791	+	Frame_Shift_Ins	INS	-	-	G			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr21:42843790_42843791insG	ENST00000398585.3	-	10	1188_1189	c.1128_1129insC	c.(1126-1131)tcagacfs	p.D377fs	TMPRSS2_ENST00000458356.1_Frame_Shift_Ins_p.D340fs|TMPRSS2_ENST00000332149.5_Frame_Shift_Ins_p.D340fs	NM_001135099.1	NP_001128571.1	O15393	TMPS2_HUMAN	transmembrane protease, serine 2	340	Peptidase S1.				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ETV1(34)|TMPRSS2/ETV5_ENST00000306376(5)|TMPRSS2/ERG(3582)|TMPRSS2/ETV4(13)	central_nervous_system(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	4		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				TTCTTGGTCTTGGAGTCATAAT	0.460			T	"""ERG, ETV1, ETV4, ETV5"""	prostate								14	130	---	---	---	---					
XBP1	7494	broad.mit.edu	37	22	29196498	29196499	+	In_Frame_Ins	INS	-	-	GCC			TCGA-KK-A6E3-01A-21D-A30E-08	TCGA-KK-A6E3-11A-11D-A30H-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b1106f74-3476-405d-93ad-b718d7f393bc	ee4e1c2b-7911-4e58-a5c2-5211c8d6ef54	g.chr22:29196498_29196499insGCC	ENST00000216037.6	-	1	86_87	c.14_15insGGC	c.(13-15)ggc>gGGCgc	p.5_6insR	XBP1_ENST00000344347.5_In_Frame_Ins_p.5_6insR|XBP1_ENST00000403532.3_In_Frame_Ins_p.5_6insR	NM_001079539.1|NM_005080.3	NP_001073007.1|NP_005071.2	P17861	XBP1_HUMAN	X-box binding protein 1	5					immune response	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|large_intestine(1)|lung(1)	5						TCGGCGCGGCTGCCACCACCAC	0.762													4	7	---	---	---	---