Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
POTEM	641455	broad.mit.edu	37	14	20010235	20010235	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr14:20010235A>G	ENST00000551509.1	-	5	974	c.923T>C	c.(922-924)gTt>gCt	p.V308A	RP11-244H18.1_ENST00000547584.1_lincRNA	NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	308										endometrium(4)|kidney(1)|lung(4)	9						AAGTATGAGAACAGTTCTAAA	0.368000													3	57					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47788901	47788901	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr4:47788901G>A	ENST00000273857.4	-	3	249	c.250C>T	c.(250-252)Cct>Tct	p.P84S	CORIN_ENST00000505909.1_Missense_Mutation_p.P84S|CORIN_ENST00000504584.1_Missense_Mutation_p.P84S|CORIN_ENST00000508498.1_5'UTR|CORIN_ENST00000502252.1_Intron	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	84					peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						GTGACCAAAGGTTCACTCCCA	0.358000													15	18					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198719693	198719693	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr1:198719693A>G	ENST00000367376.2	+	29	3310	c.3139A>G	c.(3139-3141)Atg>Gtg	p.M1047V	PTPRC_ENST00000594404.1_Missense_Mutation_p.M886V|PTPRC_ENST00000352140.3_Missense_Mutation_p.M999V|PTPRC_ENST00000348564.6_Missense_Mutation_p.M888V|PTPRC_ENST00000442510.2_Missense_Mutation_p.M1049V	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1047	Tyrosine-protein phosphatase 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						CTTTTGGCAGATGATCTTCCA	0.403000													40	62					0	0	1	0	0
LCE2C	353140	broad.mit.edu	37	1	152648603	152648603	+	Missense_Mutation	SNP	G	G	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr1:152648603G>T	ENST00000368783.1	+	2	167	c.112G>T	c.(112-114)Gct>Tct	p.A38S	LCE2B_ENST00000417924.2_Intron	NM_178429.2	NP_848516.1	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	38	Cys-rich.				keratinization					endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)	13	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACAGTGCCCAGCTCCATGTTT	0.617000													63	91					2.18419e-29	2.33228e-29	1	1	0
IQCA1	79781	broad.mit.edu	37	2	237405943	237405943	+	Nonsense_Mutation	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr2:237405943G>A	ENST00000409907.3	-	2	473	c.199C>T	c.(199-201)Cag>Tag	p.Q67*	IQCA1_ENST00000431676.2_Nonsense_Mutation_p.Q67*|IQCA1_ENST00000309507.5_Nonsense_Mutation_p.Q63*			Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	67							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						ATTCGTTTCTGGGGGTGGACG	0.473000													9	21					0	0	1	0	0
HECTD2	143279	broad.mit.edu	37	10	93220201	93220201	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr10:93220201A>G	ENST00000446394.1	+	3	386	c.286A>G	c.(286-288)Att>Gtt	p.I96V	HECTD2_ENST00000371681.4_Missense_Mutation_p.I96V|HECTD2_ENST00000298068.5_Missense_Mutation_p.I96V			Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	96					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						ACCACCACCAATTTGCCTTGA	0.353000													51	34					0	0	1	0	0
LYPLAL1	127018	broad.mit.edu	37	1	219347260	219347260	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr1:219347260C>T	ENST00000366928.5	+	1	75	c.28C>T	c.(28-30)Cag>Tag	p.Q10*	LYPLAL1_ENST00000483635.1_3'UTR|LYPLAL1_ENST00000366927.3_Nonsense_Mutation_p.Q10*|RP11-135J2.4_ENST00000441331.1_RNA	NM_138794.3	NP_620149.1	Q5VWZ2	LYPL1_HUMAN	lysophospholipase-like 1	10						cytoplasm	lysophospholipase activity			large_intestine(1)|lung(5)	6				GBM - Glioblastoma multiforme(131;0.055)|all cancers(67;0.105)|OV - Ovarian serous cystadenocarcinoma(81;0.116)		GTCGGTTCTGCAGCGCTGTAT	0.627000													19	32					0	0	1	0	0
C19orf35	374872	broad.mit.edu	37	19	2278617	2278617	+	Missense_Mutation	SNP	G	G	A	rs149444944	byFrequency	TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr19:2278617G>A	ENST00000342063.3	-	3	671	c.578C>T	c.(577-579)gCg>gTg	p.A193V		NM_198532.2	NP_940934.1	Q6ZS72	CS035_HUMAN	chromosome 19 open reading frame 35	193										large_intestine(1)|lung(5)|pancreas(1)|prostate(1)	8				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCCTCGTGCGCGCGCACCAC	0.692000													7	23					0	0	1	0	0
CCDC85A	114800	broad.mit.edu	37	2	56599551	56599551	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr2:56599551C>T	ENST00000407595.2	+	4	1892	c.1390C>T	c.(1390-1392)Cgg>Tgg	p.R464W	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	464										breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GTCCAGAGCCCGGCGGGTCTT	0.522000													3	14					0	0	1	0	0
GOLGA6B	55889	broad.mit.edu	37	15	72954612	72954612	+	Silent	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr15:72954612G>A	ENST00000421285.3	+	11	867	c.867G>A	c.(865-867)gcG>gcA	p.A289A		NM_018652.4	NP_061122.4	A6NDN3	GOG6B_HUMAN	golgin A6 family, member B	289								p.A289A(1)		NS(1)|breast(1)|endometrium(1)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	16						CATCCCTGGCGCCCCCAGCAG	0.537000													4	45					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2962846	2962846	+	Nonsense_Mutation	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr7:2962846G>A	ENST00000396946.4	-	16	2465	c.2062C>T	c.(2062-2064)Cga>Tga	p.R688*		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	688	PDZ.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		AAGCTCCCTCGCGCGTTGCCC	0.701000			Mis		DLBCL								29	10					0	0	1	0	0
TAS2R19	259294	broad.mit.edu	37	12	11174543	11174543	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr12:11174543G>A	ENST00000390673.2	-	1	676	c.628C>T	c.(628-630)Cgg>Tgg	p.R210W	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_176888.1	NP_795369.1	P59542	T2R19_HUMAN	taste receptor, type 2, member 19	210					sensory perception of taste	integral to membrane	G-protein coupled receptor activity	p.R210W(1)		breast(1)|cervix(1)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|stomach(1)	17						CTATGGAGCCGCATCTTCTTG	0.403000													4	142					0	0	1	0	0
ESX1	80712	broad.mit.edu	37	X	103498923	103498923	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chrX:103498923G>A	ENST00000372588.4	-	2	501	c.418C>T	c.(418-420)Cgc>Tgc	p.R140C		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	140					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						CGGCGGCGGCGTTTCCTCTCT	0.632000													3	39					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236143233	236143233	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr1:236143233G>A	ENST00000264187.6	-	18	3480	c.3398C>T	c.(3397-3399)gCg>gTg	p.A1133V	NID1_ENST00000366595.3_Missense_Mutation_p.A1000V	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	1133					cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CAGGCATTCCGCCCGATTGGT	0.493000													30	32					0	0	1	0	0
GRIA1	0	broad.mit.edu	37	5	153190627	153190627	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr5:153190627C>T	ENST00000285900.5	+	16	2906	c.2563C>T	c.(2563-2565)Cgg>Tgg	p.R855W	GRIA1_ENST00000518783.1_Missense_Mutation_p.R865W|GRIA1_ENST00000518142.1_Missense_Mutation_p.R775W|GRIA1_ENST00000521843.2_Missense_Mutation_p.R786W|GRIA1_ENST00000448073.4_Missense_Mutation_p.R865W|GRIA1_ENST00000340592.5_Missense_Mutation_p.R855W	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	855					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CGAAGCCATACGGACATCGAC	0.592000													32	42					0	0	1	0	0
HLTF	6596	broad.mit.edu	37	3	148793758	148793758	+	Missense_Mutation	SNP	T	T	C			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr3:148793758T>C	ENST00000310053.5	-	3	498	c.305A>G	c.(304-306)aAt>aGt	p.N102S	HLTF_ENST00000392912.2_Missense_Mutation_p.N102S|HLTF_ENST00000494055.1_Missense_Mutation_p.N102S|HLTF_ENST00000465259.1_Missense_Mutation_p.N102S	NM_003071.3|NM_139048.2	NP_003062.2|NP_620636.1	Q14527	HLTF_HUMAN	helicase-like transcription factor	102					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			TCCATTCACATTGTTTACTTT	0.318000													4	49					0	0	1	0	0
SNRPG	6637	broad.mit.edu	37	2	70520767	70520767	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr2:70520767G>C	ENST00000272348.2	-	1	136	c.15C>G	c.(13-15)caC>caG	p.H5Q	SNRPG_ENST00000454893.1_Missense_Mutation_p.H5Q|SNRPG_ENST00000429728.1_5'UTR	NM_003096.2	NP_003087.1	P62308	RUXG_HUMAN	small nuclear ribonucleoprotein polypeptide G	5					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|spliceosome assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			endometrium(1)	1						ACTCGGGAGGGTGAGCTTTGC	0.562000													24	75					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91474844	91474844	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr10:91474844A>G	ENST00000416354.1	+	8	917	c.845A>G	c.(844-846)tAt>tGt	p.Y282C	KIF20B_ENST00000260753.4_Missense_Mutation_p.Y282C|KIF20B_ENST00000394289.2_Missense_Mutation_p.Y282C|KIF20B_ENST00000371728.3_Missense_Mutation_p.Y282C			Q96Q89	KI20B_HUMAN	kinesin family member 20B	282	Kinesin-motor.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						TACAATGAATATATTTATGAC	0.299000													3	43					0	0	1	0	0
PTH1R	5745	broad.mit.edu	37	3	46944116	46944116	+	Nonsense_Mutation	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr3:46944116C>T	ENST00000449590.1	+	14	1515	c.1312C>T	c.(1312-1314)Caa>Taa	p.Q438*	PTH1R_ENST00000430002.2_Nonsense_Mutation_p.Q438*|PTH1R_ENST00000418619.1_Nonsense_Mutation_p.Q438*|PTH1R_ENST00000313049.5_Nonsense_Mutation_p.Q438*	NM_000316.2	NP_000307.1	Q03431	PTH1R_HUMAN	parathyroid hormone 1 receptor	438						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(2)|stomach(1)|urinary_tract(2)	19						GACGCTCTGGCAAGTCCAGAT	0.607000													3	37					0	0	1	0	0
TTBK2	146057	broad.mit.edu	37	15	43109261	43109261	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr15:43109261C>A	ENST00000267890.6	-	7	680	c.572G>T	c.(571-573)cGt>cTt	p.R191L	TTBK2_ENST00000567274.1_Missense_Mutation_p.R156L|TTBK2_ENST00000567840.1_Missense_Mutation_p.R191L	NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	191	Protein kinase.				cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		TGATGCATAACGAACTGTCCC	0.398000													13	14					0.00316338	0.00316338	1	1	0
NAV2	89797	broad.mit.edu	37	11	20005785	20005785	+	Silent	SNP	C	C	T	rs143699420		TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr11:20005785C>T	ENST00000396085.1	+	11	3121	c.2760C>T	c.(2758-2760)gaC>gaT	p.D920D	NAV2_ENST00000396087.3_Silent_p.D943D|NAV2_ENST00000527559.2_Silent_p.D872D|NAV2_ENST00000360655.4_Silent_p.D856D|NAV2_ENST00000349880.4_Silent_p.D920D|NAV2_ENST00000540292.1_Silent_p.D874D	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	943						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						GCCTCGGAGACGCTGACAGGT	0.587000													17	34					0	0	1	0	0
OXA1L	5018	broad.mit.edu	37	14	23239012	23239012	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr14:23239012C>T	ENST00000358043.5	+	4	722	c.404C>T	c.(403-405)gCc>gTc	p.A135V	OXA1L_ENST00000285848.5_Missense_Mutation_p.A211V|OXA1L_ENST00000604262.1_Missense_Mutation_p.A151V|OXA1L_ENST00000412791.1_Missense_Mutation_p.A151V			Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	151					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		ACAGTCTTTGCCCGCTGCCTG	0.478000													5	342					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45303942	45303942	+	Splice_Site	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr5:45303942C>T	ENST00000303230.4	-	6	1435		c.e6-1			NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1							integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TGACTATCTCCTAAAGATGTC	0.333000													28	43					0	0	1	0	0
ADAMDEC1	27299	broad.mit.edu	37	8	24261576	24261576	+	Missense_Mutation	SNP	G	G	A	rs146989743	byFrequency	TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr8:24261576G>A	ENST00000538205.1	+	14	1691	c.1144G>A	c.(1144-1146)Gga>Aga	p.G382R	RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|ADAMDEC1_ENST00000256412.4_Missense_Mutation_p.G461R|ADAMDEC1_ENST00000522298.1_Missense_Mutation_p.G382R	NM_001145271.1	NP_001138743.1	O15204	ADEC1_HUMAN	ADAM-like, decysin 1	461	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|large_intestine(4)|skin(2)|stomach(1)	9		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		AACTGATTGCGGAGGAGATGC	0.423000													16	29					0	0	1	0	0
MAB21L1	4081	broad.mit.edu	37	13	36050006	36050006	+	Silent	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr13:36050006G>A	ENST00000379919.4	-	1	826	c.270C>T	c.(268-270)gaC>gaT	p.D90D	NBEA_ENST00000379939.2_Intron|NBEA_ENST00000540320.1_Intron|NBEA_ENST00000400445.3_Intron|NBEA_ENST00000310336.4_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)	90					anatomical structure morphogenesis	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		GTGAGCCATCGTCCACGAAGT	0.577000													27	49					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72425419	72425419	+	Missense_Mutation	SNP	G	G	A	rs147025898		TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr12:72425419G>A	ENST00000333850.3	+	11	1558	c.1417G>A	c.(1417-1419)Gac>Aac	p.D473N		NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	473					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	CCTTCGCAGCGACTTGAATAC	0.418000													38	94					0	0	1	0	0
LILRB1	0	broad.mit.edu	37	19	55148290	55148290	+	Silent	SNP	A	A	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr19:55148290A>T	ENST00000396331.1	+	16	2271	c.1914A>T	c.(1912-1914)ccA>ccT	p.P638P	LILRB1_ENST00000448689.1_3'UTR|LILRB1_ENST00000427581.2_Silent_p.P689P|LILRB1_ENST00000434867.2_Silent_p.P638P|LILRB1_ENST00000396317.1_Silent_p.P622P|LILRB1_ENST00000396315.1_Silent_p.P640P|LILRB1_ENST00000324602.7_Silent_p.P640P|LILRB1_ENST00000396321.2_Silent_p.P638P|LILRB1_ENST00000396327.3_Silent_p.P639P|LILRB1_ENST00000396332.4_Silent_p.P639P|AC009892.10_ENST00000456337.1_Intron|LILRB1_ENST00000418536.2_Silent_p.P622P|LILRB1_ENST00000462628.1_3'UTR	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	638					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GGCCCTCTCCAGCTGTGCCCA	0.647000										HNSCC(37;0.09)			26	46					0	0	1	0	0
RAMP1	10267	broad.mit.edu	37	2	238786003	238786003	+	Splice_Site	SNP	A	A	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr2:238786003A>G	ENST00000254661.4	+	2	322	c.191_splice	c.e2+1	p.R64_splice	RAMP1_ENST00000409726.1_Splice_Site_p.R42_splice|RAMP1_ENST00000403885.1_Splice_Site_p.R42_splice|RAMP1_ENST00000404910.2_Splice_Site_p.R42_splice	NM_005855.2	NP_005846.1	O60894	RAMP1_HUMAN	receptor (G protein-coupled) activity modifying protein 1	64					intracellular protein transport|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane	protein transporter activity			kidney(1)|large_intestine(1)|lung(2)	4		Breast(86;0.000596)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;9.56e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.49e-11)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.49e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00013)|Lung(119;0.0119)|LUSC - Lung squamous cell carcinoma(224;0.0288)	Pramlintide(DB01278)	CAGGACCATCAGGTGAGTCCC	0.647000													28	31					0	0	1	0	0
MIS18A	54069	broad.mit.edu	37	21	33651140	33651140	+	Silent	SNP	G	G	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr21:33651140G>T	ENST00000290130.3	-	1	240	c.186C>A	c.(184-186)gcC>gcA	p.A62A	MIS18A-AS1_ENST00000453549.1_RNA	NM_018944.2	NP_061817.1	Q9NYP9	MS18A_HUMAN	MIS18 kinetochore protein A	62					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	7						TCTCCATGTCGGCCACCGACG	0.692000													5	0					0.000602214	0.000621959	1	1	0
PRPF8	10594	broad.mit.edu	37	17	1563231	1563231	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr17:1563231C>T	ENST00000572621.1	-	30	5115	c.4850G>A	c.(4849-4851)cGa>cAa	p.R1617Q	PRPF8_ENST00000304992.6_Missense_Mutation_p.R1617Q			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1617						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		ATATGACTTTCGGGGATGGAT	0.443000													24	41					0	0	1	0	0
TRAJ12	0	broad.mit.edu	37	14	23000897	23000897	+	RNA	SNP	A	A	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr14:23000897A>G	ENST00000390525.1	+	0	9																											TGGGATGGATAGCAGCTATAA	0.458000													30	47					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22939396	22939396	+	Silent	SNP	A	A	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr19:22939396A>G	ENST00000397104.3	-	7	2774	c.2775T>C	c.(2773-2775)ttT>ttC	p.F925F						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AGGATTGCTTAAAAGCTTTGC	0.378000													10	26					0	0	1	0	0
FEM1A	55527	broad.mit.edu	37	19	4792690	4792690	+	Missense_Mutation	SNP	C	C	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr19:4792690C>A	ENST00000269856.3	+	1	963	c.824C>A	c.(823-825)tCc>tAc	p.S275Y	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	275					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		TGCTGCAGCTCCTCCCCAGAG	0.647000													19	31					8.00594e-06	8.40624e-06	1	1	0
CYP2S1	29785	broad.mit.edu	37	19	41704370	41704370	+	Missense_Mutation	SNP	G	G	A	rs45457494	byFrequency	TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr19:41704370G>A	ENST00000310054.4	+	4	713	c.497G>A	c.(496-498)cGc>cAc	p.R166H	CYP2S1_ENST00000542619.1_Intron	NM_030622.6	NP_085125.1	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S, polypeptide 1	166					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(2)	14						CCCCCAGGACGCCCATTCGAT	0.627000													47	74					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20269374	20269374	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr20:20269374C>G	ENST00000245957.5	+	23	2994	c.2918C>G	c.(2917-2919)gCc>gGc	p.A973G	C20orf26_ENST00000377309.2_Intron	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	973										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		AACGACATAGCCATCAGAGCT	0.428000													47	75					0	0	1	0	0
DDX18	8886	broad.mit.edu	37	2	118577297	118577297	+	Missense_Mutation	SNP	A	A	C			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr2:118577297A>C	ENST00000263239.2	+	3	571	c.443A>C	c.(442-444)gAa>gCa	p.E148A	DDX18_ENST00000474694.1_3'UTR	NM_006773.3	NP_006764.3	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	148							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						AAAGAAACAGAAAATAATGTG	0.398000											OREG0003814	type=REGULATORY REGION|Gene=DDX18|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	21	18					0	0	1	0	0
STYK1	55359	broad.mit.edu	37	12	10777358	10777358	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr12:10777358G>A	ENST00000075503.3	-	8	1338	c.818C>T	c.(817-819)gCt>gTt	p.A273V		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	273	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						AACTTCATAAGCCAGGCCTAA	0.507000										HNSCC(73;0.22)			50	89					0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53185077	53185077	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr12:53185077C>T	ENST00000417996.2	-	7	1522	c.1448G>A	c.(1447-1449)cGt>cAt	p.R483H	KRT3_ENST00000309505.3_Missense_Mutation_p.R483H	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	483	Coil 2.|Rod.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity	p.R483H(1)		NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						CTGGTAGTCACGTAGCAGCCG	0.607000													42	67					0	0	1	0	0
XRCC6	2547	broad.mit.edu	37	22	42042990	42042990	+	Silent	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr22:42042990C>T	ENST00000359308.4	+	6	1519	c.864C>T	c.(862-864)ctC>ctT	p.L288L	XRCC6_ENST00000405506.1_Silent_p.L238L|XRCC6_ENST00000405878.1_Silent_p.L288L|XRCC6_ENST00000428575.2_Silent_p.L155L|XRCC6_ENST00000402580.3_Silent_p.L247L|XRCC6_ENST00000360079.3_Silent_p.L288L			P12956	XRCC6_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 6	288	Ku.				DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	31						CAATAAAGCTCTATCGGGAAA	0.458000								Non-homologous end-joining					65	112					0	0	1	0	0
C2CD5	9847	broad.mit.edu	37	12	22646232	22646232	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr12:22646232C>T	ENST00000333957.4	-	11	1442	c.1187G>A	c.(1186-1188)aGa>aAa	p.R396K	C2CD5_ENST00000542676.1_Missense_Mutation_p.R396K|C2CD5_ENST00000536386.1_Missense_Mutation_p.R398K|C2CD5_ENST00000446597.1_Missense_Mutation_p.R396K|C2CD5_ENST00000545552.1_Missense_Mutation_p.R409K|C2CD5_ENST00000396028.2_Missense_Mutation_p.R387K|C2CD5_ENST00000544930.1_Missense_Mutation_p.R211K	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		TATTTCTTGTCTGATTTCTGC	0.328000													4	108					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144062368	144062368	+	Missense_Mutation	SNP	A	A	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr7:144062368A>G	ENST00000056217.5	+	2	2780	c.2606A>G	c.(2605-2607)cAt>cGt	p.H869R		NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	869					intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					CGGGGAGGACATATGAACTCA	0.622000													4	94					0	0	1	0	0
SPAG9	9043	broad.mit.edu	37	17	49057179	49057179	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr17:49057179G>C	ENST00000262013.7	-	26	3545	c.3337C>G	c.(3337-3339)Cgt>Ggt	p.R1113G	SPAG9_ENST00000510283.1_Missense_Mutation_p.R956G|SPAG9_ENST00000357122.4_Missense_Mutation_p.R1099G|SPAG9_ENST00000505279.1_Missense_Mutation_p.R1103G	NM_001130528.2	NP_001124000.1	O60271	JIP4_HUMAN	sperm associated antigen 9	1113					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			TGATAGAGACGGAGCGTAGAA	0.478000													29	55					0	0	1	0	0
PCDHA13	0	broad.mit.edu	37	5	140262056	140262056	+	Missense_Mutation	SNP	C	C	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr5:140262056C>G	ENST00000289272.2	+	1	203	c.203C>G	c.(202-204)tCc>tGc	p.S68C	PCDHA3_ENST00000522353.2_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.S68C|PCDHA11_ENST00000398640.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGTGGCGTCCAAAAGACAC	0.627000													5	168					0	0	1	0	0
COLGALT1	79709	broad.mit.edu	37	19	17688065	17688065	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr19:17688065G>C	ENST00000252599.4	+	7	1131	c.1011G>C	c.(1009-1011)aaG>aaC	p.K337N		NM_024656.2	NP_078932.2			collagen beta(1-O)galactosyltransferase 1																		CACCGGACAAGATGGGCTTCG	0.672000													9	25					0	0	1	0	0
CES5A	221223	broad.mit.edu	37	16	55907858	55907858	+	Translation_Start_Site	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr16:55907858G>A	ENST00000518005.1	-	0	229				CES5A_ENST00000290567.9_Silent_p.N55N|CES5A_ENST00000541580.1_Intron|CES5A_ENST00000521992.1_Silent_p.N84N|CES5A_ENST00000520435.1_Silent_p.N55N|CES5A_ENST00000319165.9_Silent_p.N55N			Q6NT32	EST5A_HUMAN	carboxylesterase 5A							extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CGAGGAACACGTTCACAGGCA	0.612000													6	10					0	0	1	0	0
CD69	969	broad.mit.edu	37	12	9913370	9913370	+	Missense_Mutation	SNP	G	G	C			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr12:9913370G>C	ENST00000228434.3	-	1	127	c.47C>G	c.(46-48)cCg>cGg	p.P16R	CD69_ENST00000536709.1_Missense_Mutation_p.P16R	NM_001781.2	NP_001772.1	Q07108	CD69_HUMAN	CD69 molecule	16						integral to plasma membrane	sugar binding|transmembrane receptor activity			endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)	10						TCCACTCTCCGGATGCAAAGA	0.363000													26	50					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152420177	152420177	+	Silent	SNP	C	C	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr2:152420177C>G	ENST00000397345.3	-	119	18838	c.18636G>C	c.(18634-18636)gtG>gtC	p.V6212V	NEB_ENST00000603639.1_Silent_p.V6212V|NEB_ENST00000409198.1_Silent_p.V4511V|NEB_ENST00000427231.2_Silent_p.V6212V|NEB_ENST00000604864.1_Silent_p.V6212V|NEB_ENST00000172853.10_Silent_p.V4511V	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	6194					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		ATTCACCGATCACTTTTCCAG	0.433000													17	224					0	0	1	0	0
SLC4A9	83697	broad.mit.edu	37	5	139745496	139745496	+	Silent	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr5:139745496C>T	ENST00000230993.6	+	13	1895	c.1860C>T	c.(1858-1860)ggC>ggT	p.G620G	SLC4A9_ENST00000507527.1_Silent_p.G620G|SLC4A9_ENST00000506757.2_Silent_p.G596G|SLC4A9_ENST00000506545.1_Intron|SLC4A9_ENST00000432095.2_Silent_p.G582G	NM_001258428.1	NP_001245357.1	Q96Q91	B3A4_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 9	620	Membrane (anion exchange).					integral to membrane|plasma membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGCCCTGGCTGTCATACAG	0.557000													54	100					0	0	1	0	0
SLC44A4	80736	broad.mit.edu	37	6	31832450	31832450	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr6:31832450C>T	ENST00000544672.1	-	20	2058	c.1762G>A	c.(1762-1764)Gac>Aac	p.D588N	SLC44A4_ENST00000375562.4_Missense_Mutation_p.D622N|SLC44A4_ENST00000229729.6_Missense_Mutation_p.D664N	NM_001178045.1	NP_001171516.1	Q53GD3	CTL4_HUMAN	solute carrier family 44, member 4	664						integral to membrane|plasma membrane	choline transmembrane transporter activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(1)|urinary_tract(2)	35					Choline(DB00122)	AAGAGCGTGTCCACACACATG	0.522000													26	65					0	0	1	0	0
BBX	56987	broad.mit.edu	37	3	107497259	107497259	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr3:107497259G>A	ENST00000415149.2	+	13	2423	c.2096G>A	c.(2095-2097)aGc>aAc	p.S699N	BBX_ENST00000325805.8_Missense_Mutation_p.S699N|BBX_ENST00000473542.1_3'UTR|BBX_ENST00000402543.1_Missense_Mutation_p.S699N|BBX_ENST00000406780.1_Missense_Mutation_p.S699N|BBX_ENST00000416476.2_Missense_Mutation_p.A363T	NM_001142568.1|NM_020235.5	NP_001136040.1|NP_064620.2	Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	699	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			AAATTCAACAGCCTCCCTCAA	0.408000													33	56					0	0	1	0	0
AKR1C3	8644	broad.mit.edu	37	10	5139704	5139704	+	Translation_Start_Site	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr10:5139704G>A	ENST00000439082.2	+	0	444				AKR1C3_ENST00000470862.2_3'UTR|AKR1C3_ENST00000605149.1_Missense_Mutation_p.V88I|AKR1C3_ENST00000380554.3_Missense_Mutation_p.V111I			P42330	AK1C3_HUMAN	aldo-keto reductase family 1, member C3						prostaglandin metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|androsterone dehydrogenase (A-specific) activity|indanol dehydrogenase activity|prostaglandin-F synthase activity|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|skin(1)	14					Dimethyl sulfoxide(DB01093)|NADH(DB00157)	ATTGGACTATGTTGACCTCTA	0.403000													34	46					0	0	1	0	0
SNHG14	0	broad.mit.edu	37	15	25326458	25326458	+	RNA	SNP	A	A	G			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr15:25326458A>G	ENST00000546682.1	+	0	71				SNORD116-15_ENST00000384445.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						TTCCATATATACATTCCTTGG	0.463000													4	219					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126135240	126135240	+	Missense_Mutation	SNP	C	C	T			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr3:126135240C>T	ENST00000393425.1	+	5	406	c.307C>T	c.(307-309)Cgg>Tgg	p.R103W	CCDC37_ENST00000352312.1_Missense_Mutation_p.R103W|CCDC37_ENST00000505024.1_Missense_Mutation_p.R103W			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	103										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		CACCAGCCTGCGGCGGCAGCT	0.662000													3	39					0	0	1	0	0
PCDHB8	0	broad.mit.edu	37	5	140558166	140558166	+	Missense_Mutation	SNP	G	G	A			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr5:140558166G>A	ENST00000239444.2	+	1	796	c.551G>A	c.(550-552)cGc>cAc	p.R184H		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		184	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R184H(1)		NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTCCTCACCCGCAAACGCAGT	0.483000													4	116					0	0	1	0	0
ZNF577	84765	broad.mit.edu	37	19	52376325	52376325	+	Silent	SNP	G	G	C			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr19:52376325G>C	ENST00000420592.1	-	6	2074	c.741C>G	c.(739-741)acC>acG	p.T247T	ZNF577_ENST00000485702.1_Intron|ZNF577_ENST00000451628.2_Silent_p.T247T|ZNF577_ENST00000301399.5_Silent_p.T306T|ZNF577_ENST00000412216.1_Intron			Q9BSK1	ZN577_HUMAN	zinc finger protein 577	306					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TAAAATAGAAGGTTCTTCCAC	0.433000													22	56					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47583591	47583591	+	Frame_Shift_Del	DEL	A	A	-			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr1:47583591delA	ENST00000334194.3	+	12	1506	c.1503delA	c.(1501-1503)gcfs	p.A501fs	CYP4A22-AS1_ENST00000444042.2_lincRNA|CYP4Z1_ENST00000471598.1_3'UTR	NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	501						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						ATGTGTTTGCAAAAAAAGTTT	0.383													7	27	---	---	---	---					
TPD52L1	0	broad.mit.edu	37	6	125550359	125550359	+	Frame_Shift_Del	DEL	T	T	-			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr6:125550359delT	ENST00000534000.1	+	3	527	c.231delT	c.(229-231)aafs	p.N77fs	TPD52L1_ENST00000532429.1_Frame_Shift_Del_p.N48fs|TPD52L1_ENST00000392482.2_Frame_Shift_Del_p.N48fs|TPD52L1_ENST00000524679.1_Frame_Shift_Del_p.N48fs|TPD52L1_ENST00000528193.1_Frame_Shift_Del_p.N77fs|TPD52L1_ENST00000368388.2_Frame_Shift_Del_p.N77fs|TPD52L1_ENST00000527711.1_Frame_Shift_Del_p.N77fs|TPD52L1_ENST00000304877.13_Frame_Shift_Del_p.N77fs|TPD52L1_ENST00000368402.5_Frame_Shift_Del_p.N77fs|TPD52L1_ENST00000534199.1_Frame_Shift_Del_p.N48fs	NM_003287.2	NP_003278.1	Q16890	TPD53_HUMAN	tumor protein D52-like 1	77					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|large_intestine(2)|prostate(1)	5			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		ACCTGATGAATGAATTAAAAC	0.388													43	56	---	---	---	---					
DLX6	1750	broad.mit.edu	37	7	96639271	96639271	+	Frame_Shift_Del	DEL	G	G	-			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr7:96639271delG	ENST00000518156.2	+	3	1224	c.794delG	c.(793-795)atfs	p.S265fs	DLX6-AS1_ENST00000458352.2_RNA|DLX6_ENST00000493273.2_3'UTR|DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000437331.2_RNA|DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000430027.2_RNA|DLX6-AS1_ENST00000437541.1_RNA|DLX6_ENST00000007660.5_Frame_Shift_Del_p.S237fs|DLX6-AS1_ENST00000605417.1_RNA|DLX6_ENST00000555308.1_Frame_Shift_Del_p.S137fs			P56179	DLX6_HUMAN	distal-less homeobox 6	147					nervous system development|skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|liver(2)|lung(4)|ovary(2)|urinary_tract(1)	12	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					AAGGGTGTCAGTATGCCCCCC	0.627													21	12	---	---	---	---					
ZKSCAN5	23660	broad.mit.edu	37	7	99123549	99123550	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr7:99123549_99123550delTT	ENST00000394170.2	+	6	1137_1138	c.886_887delTT	c.(886-888)tfs	p.F296fs	ZKSCAN5_ENST00000451158.1_Frame_Shift_Del_p.F296fs|ZKSCAN5_ENST00000326775.5_Frame_Shift_Del_p.F296fs	NM_014569.3	NP_055384.1	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	296					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	21	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGATCCAGACTTTGCAGAAGTC	0.500													21	88	---	---	---	---					
KRT76	51350	broad.mit.edu	37	12	53162773	53162775	+	In_Frame_Del	DEL	ACT	ACT	-	rs1464423	by1000genomes	TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr12:53162773_53162775delACT	ENST00000332411.2	-	9	1692_1694	c.1639_1641delAGT	c.(1639-1641)del	p.S547del		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	547	Tail.				cytoskeleton organization	keratin filament	structural molecule activity	p.S547_G548insS(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ctccatagccactgctgctgctg	0.635													2	4	---	---	---	---					
FMN1	342184	broad.mit.edu	37	15	33261122	33261123	+	In_Frame_Ins	INS	-	-	CAA			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr15:33261122_33261123insCAA	ENST00000334528.9	-	4	2109_2110	c.2110_2111insTTG	c.(2110-2112)acc>TTGacc	p.703_704insL	FMN1_ENST00000561249.1_In_Frame_Ins_p.828_829insL|FMN1_ENST00000559047.1_In_Frame_Ins_p.926_927insL	NM_001103184.2	NP_001096654.1	Q68DA7	FMN1_HUMAN	formin 1	926	Mediates interaction with alpha-catenin (By similarity).				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	29		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		AAgtgggggtgggggtgggggt	0.673													2	4	---	---	---	---					
SMAD2	4087	broad.mit.edu	37	18	45368212	45368215	+	Frame_Shift_Del	DEL	AGCA	AGCA	-			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr18:45368212_45368215delAGCA	ENST00000402690.2	-	11	1781_1784	c.1387_1390delTGCT	c.(1387-1392)cafs	p.CS463fs	SMAD2_ENST00000586040.1_Frame_Shift_Del_p.CS433fs|SMAD2_ENST00000262160.6_Frame_Shift_Del_p.CS463fs|SMAD2_ENST00000356825.4_Frame_Shift_Del_p.CS433fs	NM_001003652.3	NP_001003652.1	Q15796	SMAD2_HUMAN	SMAD family member 2	463	MH2.				anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding	p.R462fs*>4(1)		breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(21)|liver(1)|lung(8)|prostate(2)|urinary_tract(1)	43						GACATGCTTGAGCAACGCACTGAA	0.431													14	45	---	---	---	---					
GZF1	64412	broad.mit.edu	37	20	23345921	23345923	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-KK-A7AY-01A-11D-A33T-08	TCGA-KK-A7AY-11A-21D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	80ac0a78-2ebc-488d-a0db-c2fda0b57966	258a8d92-ed5a-4028-a93f-28b61fa48dec	g.chr20:23345921_23345923delGAG	ENST00000338121.5	+	2	978_980	c.901_903delGAG	c.(901-903)del	p.E306del	GZF1_ENST00000544236.1_Intron|GZF1_ENST00000542987.1_Intron|GZF1_ENST00000377051.2_In_Frame_Del_p.E306del|GZF1_ENST00000461789.1_3'UTR			Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	306					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|urinary_tract(2)	24	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					ggaggaggaagaggaggaggagg	0.532													7	56	---	---	---	---