Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SMARCA1	6594	broad.mit.edu	37	X	128624100	128624100	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chrX:128624100C>T	ENST00000371122.4	-	15	2014	c.1885G>A	c.(1885-1887)Gaa>Aaa	p.E629K	SMARCA1_ENST00000371123.1_Missense_Mutation_p.E617K|SMARCA1_ENST00000371121.3_Missense_Mutation_p.E617K	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	629	Helicase C-terminal.				ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						ATCCTCTCTTCAACAGTGTTG	0.353000													23	6					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149497216	149497216	+	Silent	SNP	G	G	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr5:149497216G>A	ENST00000261799.4	-	22	3571	c.3102C>T	c.(3100-3102)gaC>gaT	p.D1034D		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	1034					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GTGGGCCCTCGTCAGCAACCT	0.602000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								20	21					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr20:29628245G>A	ENST00000278882.3	+	6	627	c.247G>A	c.(247-249)Gcc>Acc	p.A83T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A83T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A88T														p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													5	199					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98737795	98737795	+	Missense_Mutation	SNP	T	T	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr2:98737795T>A	ENST00000477737.1	+	5	780	c.576T>A	c.(574-576)aaT>aaA	p.N192K	VWA3B_ENST00000451075.2_Missense_Mutation_p.N42K|VWA3B_ENST00000435344.1_Missense_Mutation_p.N192K	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	192										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GGCAGGAAAATGCTACTCCTG	0.542000													6	30					0	0	1	0	0
HRNR	388697	broad.mit.edu	37	1	152192638	152192638	+	Silent	SNP	G	G	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr1:152192638G>A	ENST00000368801.2	-	3	1542	c.1467C>T	c.(1465-1467)tcC>tcT	p.S489S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	489					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCGTGGCCGGAGGAGTGAC	0.542000													5	251					0	0	1	0	0
FERMT2	10979	broad.mit.edu	37	14	53331155	53331155	+	Silent	SNP	C	C	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr14:53331155C>T	ENST00000395631.2	-	12	1782	c.1566G>A	c.(1564-1566)gtG>gtA	p.V522V	FERMT2_ENST00000553373.1_Silent_p.V522V|FERMT2_ENST00000399304.3_Silent_p.V522V|FERMT2_ENST00000341590.3_Silent_p.V522V|FERMT2_ENST00000343279.4_Silent_p.V522V			Q96AC1	FERM2_HUMAN	fermitin family member 2	522	FERM.				actin cytoskeleton organization|cell adhesion|cell junction assembly|regulation of cell shape	cell cortex|cytosol|focal adhesion|stress fiber	binding		ERO1L/FERMT2(2)	NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Breast(41;0.0342)					AGCGGGGAGACACCAAACATT	0.348000													48	52					0	0	1	0	0
HCG17	0	broad.mit.edu	37	6	30227442	30227442	+	RNA	SNP	T	T	G			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr6:30227442T>G	ENST00000453558.1	-	0	126				HLA-L_ENST00000463348.1_RNA																							CTGCTGCTCTTGGGGGCCCTG	0.706000													6	22					0	0	1	0	0
MED23	9439	broad.mit.edu	37	6	131915293	131915293	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr6:131915293G>A	ENST00000403834.3	-	23	3369	c.3196C>T	c.(3196-3198)Cct>Tct	p.P1066S	MED23_ENST00000368060.3_Missense_Mutation_p.P1060S|MED23_ENST00000545957.1_Missense_Mutation_p.P701S|MED23_ENST00000479213.1_5'UTR|MED23_ENST00000354577.4_Missense_Mutation_p.P1066S|MED23_ENST00000368058.1_Missense_Mutation_p.P1066S|MED23_ENST00000368068.3_Missense_Mutation_p.P1060S			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	1060					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		GGAACCCAAGGATTTTCCTCT	0.428000													27	33					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79741159	79741159	+	Missense_Mutation	SNP	A	A	G			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr5:79741159A>G	ENST00000338008.5	+	6	2839	c.2659A>G	c.(2659-2661)Aaa>Gaa	p.K887E	ZFYVE16_ENST00000510158.1_Missense_Mutation_p.K887E|ZFYVE16_ENST00000505560.1_Missense_Mutation_p.K887E	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	887					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		AGATACAACAAAATTATCATC	0.348000													21	33					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459777	107459777	+	Silent	SNP	C	C	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr2:107459777C>T	ENST00000409382.3	-	2	1267	c.657G>A	c.(655-657)ccG>ccA	p.P219P	ST6GAL2_ENST00000361686.4_Silent_p.P219P|ST6GAL2_ENST00000409087.3_Silent_p.P219P	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	219					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						TCTGCAGGCGCGGGTTCAGCA	0.642000													11	7					0	0	1	0	0
CLDN7	1366	broad.mit.edu	37	17	7163815	7163815	+	Missense_Mutation	SNP	A	A	C			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr17:7163815A>C	ENST00000360325.7	-	4	948	c.514T>G	c.(514-516)Tct>Gct	p.S172A	CLDN7_ENST00000538261.3_Silent_p.G143G|RP1-4G17.5_ENST00000577138.1_Intron|CLDN7_ENST00000397317.4_Missense_Mutation_p.S172A	NM_001307.5	NP_001298.3	O95471	CLD7_HUMAN	claudin 7	172					calcium-independent cell-cell adhesion	integral to membrane|lateral plasma membrane|tight junction	identical protein binding|structural molecule activity	p.S172A(1)		kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	6						ACTAGGGCAGACCCTGCCCAG	0.572000													4	7					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430947	37430947	+	Nonsense_Mutation	SNP	G	G	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr10:37430947G>A	ENST00000374660.1	+	7	1053	c.954G>A	c.(952-954)tgG>tgA	p.W318*	ANKRD30A_ENST00000602533.1_Nonsense_Mutation_p.W318*|ANKRD30A_ENST00000361713.1_Nonsense_Mutation_p.W318*			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	374						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AATTTACGTGGCCAGCAAAAG	0.423000													21	80					0	0	1	0	0
FCRL5	83416	broad.mit.edu	37	1	157491070	157491070	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr1:157491070C>T	ENST00000361835.3	-	11	2409	c.2252G>A	c.(2251-2253)cGc>cAc	p.R751H	FCRL5_ENST00000356953.4_Missense_Mutation_p.R751H|FCRL5_ENST00000461387.1_5'UTR	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	751						integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GAGGACCGGGCGAGACACCGG	0.507000													8	24					0	0	1	0	0
PRRC2A	7916	broad.mit.edu	37	6	31599394	31599394	+	Missense_Mutation	SNP	G	G	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr6:31599394G>T	ENST00000376033.2	+	16	3178	c.2944G>T	c.(2944-2946)Gac>Tac	p.D982Y	PRRC2A_ENST00000376007.4_Missense_Mutation_p.D982Y	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	982	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CCCAAAGCCAGACCCACTCAA	0.567000													10	10					7.48243e-07	7.6487e-07	1	1	0
ASGR1	432	broad.mit.edu	37	17	7080598	7080598	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr17:7080598G>A	ENST00000269299.3	-	3	517	c.118C>T	c.(118-120)Cgc>Tgc	p.R40C	ASGR1_ENST00000574388.1_Intron|ASGR1_ENST00000572879.1_5'UTR|ASGR1_ENST00000380920.4_5'UTR	NM_001197216.2|NM_001671.4	NP_001184145.1|NP_001662.1	P07306	ASGR1_HUMAN	asialoglycoprotein receptor 1	40					receptor-mediated endocytosis	integral to plasma membrane	asialoglycoprotein receptor activity|metal ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	10						AGGAGGAGGCGAGGTCCGGAG	0.682000											OREG0024128	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	40					0	0	1	0	0
TMEM175	84286	broad.mit.edu	37	4	952220	952220	+	Missense_Mutation	SNP	A	A	C			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr4:952220A>C	ENST00000264771.4	+	11	1636	c.1451A>C	c.(1450-1452)cAc>cCc	p.H484P	TMEM175_ENST00000508204.1_Missense_Mutation_p.H402P|TMEM175_ENST00000515740.1_Missense_Mutation_p.H368P	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	484						integral to membrane		p.H484P(1)		NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CGGCCCGAACACCCCCCGCCA	0.736000													9	11					0	0	1	0	0
MIER1	57708	broad.mit.edu	37	1	67424570	67424570	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr1:67424570G>A	ENST00000357692.2	+	7	687	c.430G>A	c.(430-432)Gaa>Aaa	p.E144K	MIER1_ENST00000371018.3_Missense_Mutation_p.E144K|MIER1_ENST00000371014.1_Missense_Mutation_p.E180K|MIER1_ENST00000355356.3_Missense_Mutation_p.E127K|MIER1_ENST00000401042.3_Missense_Mutation_p.E127K|MIER1_ENST00000401041.1_Missense_Mutation_p.E180K|MIER1_ENST00000479067.1_3'UTR|MIER1_ENST00000371016.1_Missense_Mutation_p.E144K|MIER1_ENST00000355977.6_Missense_Mutation_p.E64K	NM_001146110.1	NP_001139582.1	Q8N108	MIER1_HUMAN	mesoderm induction early response 1, transcriptional regulator	151	Glu-rich.				positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|urinary_tract(3)	15						TCAGGAGGATGAAACTCAGTC	0.368000													22	29					0	0	1	0	0
ZMIZ2	83637	broad.mit.edu	37	7	44806203	44806203	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr7:44806203G>A	ENST00000309315.4	+	18	2719	c.2596G>A	c.(2596-2598)Ggc>Agc	p.G866S	ZMIZ2_ENST00000463931.1_3'UTR|ZMIZ2_ENST00000441627.1_Missense_Mutation_p.G866S|ZMIZ2_ENST00000433667.1_Missense_Mutation_p.G834S|ZMIZ2_ENST00000413916.1_Missense_Mutation_p.G808S|ZMIZ2_ENST00000265346.7_Missense_Mutation_p.G840S	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	866	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						TCCTGCCACAGGCGTGATGGG	0.672000													34	32					0	0	1	0	0
CLDN10	9071	broad.mit.edu	37	13	96212468	96212468	+	Missense_Mutation	SNP	G	G	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr13:96212468G>T	ENST00000376873.3	+	2	527	c.297G>T	c.(295-297)atG>atT	p.M99I	CLDN10_ENST00000376855.1_Missense_Mutation_p.M19I|CLDN10_ENST00000299339.2_Missense_Mutation_p.M101I	NM_001160100.1|NM_182848.3	NP_001153572.1|NP_878268.1	P78369	CLD10_HUMAN	claudin 10	101					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	15	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			TCTTTGGAATGAAGTGTACCA	0.428000													36	38					9.04072e-19	1.01432e-18	1	1	0
MPHOSPH10	10199	broad.mit.edu	37	2	71376384	71376384	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr2:71376384C>T	ENST00000244230.2	+	10	2049	c.1697C>T	c.(1696-1698)gCt>gTt	p.A566V		NM_005791.2	NP_005782.1	O00566	MPP10_HUMAN	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)	566					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|pancreas(2)|skin(2)|stomach(1)	26						ATAAAAACAGCTGCTGAAAAA	0.333000													6	8					0	0	1	0	0
MAP4K3	8491	broad.mit.edu	37	2	39517448	39517448	+	Silent	SNP	A	A	G			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr2:39517448A>G	ENST00000263881.3	-	19	1623	c.1299T>C	c.(1297-1299)ccT>ccC	p.P433P	MAP4K3_ENST00000437545.1_Silent_p.P349P|MAP4K3_ENST00000341681.5_Silent_p.P412P|MAP4K3_ENST00000536018.1_5'UTR	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3	433					JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				GTGGCAAAGGAGGTGGAATTT	0.279000													15	18					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161618	90161618	+	RNA	SNP	C	C	T	rs13338202	by1000genomes	TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr16:90161618C>T	ENST00000564451.1	+	0	971				TUBB8P7_ENST00000567960.1_RNA														p.D118D(2)									CAGTGATGGACGTTGTCAGAA	0.607000													3	25					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78685178	78685178	+	Missense_Mutation	SNP	C	C	G			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr3:78685178C>G	ENST00000436010.2	-	21	3998	c.3001G>C	c.(3001-3003)Gat>Cat	p.D1001H	ROBO1_ENST00000464233.1_Missense_Mutation_p.D1040H|ROBO1_ENST00000495273.1_Missense_Mutation_p.D995H|ROBO1_ENST00000467549.1_Intron			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1040					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AGGTCCACATCACCATAAACA	0.398000													21	32					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31385104	31385104	+	Splice_Site	SNP	C	C	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr20:31385104C>T	ENST00000328111.2	+	14	1810	c.1490_splice	c.e14+1	p.R497_splice	DNMT3B_ENST00000353855.2_Splice_Site_p.R477_splice|DNMT3B_ENST00000348286.2_Splice_Site_p.R477_splice|DNMT3B_ENST00000201963.3_Splice_Site_p.R489_splice|DNMT3B_ENST00000344505.4_Splice_Site_p.R477_splice|DNMT3B_ENST00000456297.2_Splice_Site_p.R401_splice|DNMT3B_ENST00000443239.3_Splice_Site_p.R435_splice|DNMT3B_ENST00000375623.4_3'UTR	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	497	ADD.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GAGCTGCTGCCGGTGAGCACT	0.572000													38	41					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17826029	17826029	+	Nonsense_Mutation	SNP	C	C	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr6:17826029C>A	ENST00000378814.5	-	16	1755	c.1756G>T	c.(1756-1758)Gaa>Taa	p.E586*	KIF13A_ENST00000378843.2_Nonsense_Mutation_p.E586*|KIF13A_ENST00000378826.2_Nonsense_Mutation_p.E586*|KIF13A_ENST00000259711.6_Nonsense_Mutation_p.E586*|KIF13A_ENST00000378816.5_Nonsense_Mutation_p.E586*	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	586					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			ATGATAACTTCCATCTGTGCA	0.473000													31	33					7.01153e-11	7.6793e-11	1	1	0
OR5D16	390144	broad.mit.edu	37	11	55607153	55607153	+	Missense_Mutation	SNP	C	C	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr11:55607153C>A	ENST00000378396.1	+	1	926	c.926C>A	c.(925-927)aCa>aAa	p.T309K		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				ATAATCAATACAAAATATTTT	0.328000													10	9					9.70103e-10	1.03778e-09	1	1	0
CCDC107	203260	broad.mit.edu	37	9	35660414	35660414	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr9:35660414C>T	ENST00000421582.2	+	3	338	c.275C>T	c.(274-276)gCg>gTg	p.A92V	ARHGEF39_ENST00000343259.3_3'UTR|ARHGEF39_ENST00000378395.2_3'UTR|CCDC107_ENST00000426546.2_Missense_Mutation_p.A92V|CCDC107_ENST00000378406.1_Missense_Mutation_p.A92V|CCDC107_ENST00000327351.2_Missense_Mutation_p.A92V|CCDC107_ENST00000378407.3_Missense_Mutation_p.A92V|ARHGEF39_ENST00000378387.3_3'UTR|CCDC107_ENST00000378409.3_Missense_Mutation_p.A92V			Q8WV48	CC107_HUMAN	coiled-coil domain containing 107	92						integral to membrane				endometrium(1)|lung(3)|skin(1)	5	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GATGAAACTGCGGTTCTCCAC	0.547000													21	35					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54554926	54554926	+	Silent	SNP	C	C	T	rs146488724	byFrequency	TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr17:54554926C>T	ENST00000566473.2	+	15	1860	c.1860C>T	c.(1858-1860)agC>agT	p.S620S	ANKFN1_ENST00000318698.2_Silent_p.S620S			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	620										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						AGCTCTGTAGCTCTGTGGATC	0.373000													36	59					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S|FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													5	201					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52551013	52551013	+	Silent	SNP	C	C	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr3:52551013C>T	ENST00000321725.6	+	42	4453	c.4377C>T	c.(4375-4377)tgC>tgT	p.C1459C		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1459	EGF-like 11.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TGGACCCCTGCGCCCACGGCC	0.662000													32	31					0	0	1	0	0
ZNF235	9310	broad.mit.edu	37	19	44793323	44793323	+	Missense_Mutation	SNP	T	T	C			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr19:44793323T>C	ENST00000291182.4	-	5	367	c.265A>G	c.(265-267)Act>Gct	p.T89A	ZNF235_ENST00000589248.1_Intron|ZNF235_ENST00000589799.1_Intron	NM_004234.4	NP_004225.3	Q14590	ZN235_HUMAN	zinc finger protein 235	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29		Prostate(69;0.0352)|all_neural(266;0.116)				TTGTGAAGAGTTGCCATCTCA	0.408000													31	30					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207867727	207867727	+	Missense_Mutation	SNP	G	G	C			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr1:207867727G>C	ENST00000508064.2	+	5	553	c.493G>C	c.(493-495)Gcc>Ccc	p.A165P	CR1L_ENST00000530905.1_Intron	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	165	Sushi 3.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CCCCACCATCGCCAATGGAGA	0.423000													28	34					0	0	1	0	0
IGFBP4	3487	broad.mit.edu	37	17	38610295	38610295	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr17:38610295G>A	ENST00000269593.4	+	3	898	c.623G>A	c.(622-624)gGc>gAc	p.G208D	IGFBP4_ENST00000542955.1_Missense_Mutation_p.G108D	NM_001552.2	NP_001543.2	P22692	IBP4_HUMAN	insulin-like growth factor binding protein 4	208	Thyroglobulin type-1.				DNA metabolic process|signal transduction|skeletal system development					NS(1)|endometrium(1)|kidney(1)|large_intestine(2)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GACCGCAACGGCAACTTCCAC	0.662000													4	115					0	0	1	0	0
ZNF250	58500	broad.mit.edu	37	8	146108153	146108153	+	Missense_Mutation	SNP	C	C	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr8:146108153C>A	ENST00000292579.7	-	6	546	c.430G>T	c.(430-432)Gtg>Ttg	p.V144L	ZNF250_ENST00000543949.1_Intron|ZNF250_ENST00000342660.6_Intron|ZNF250_ENST00000417550.2_Missense_Mutation_p.V139L	NM_001109689.3|NM_021061.4	NP_001103159.1|NP_066405.1	P15622	ZN250_HUMAN	zinc finger protein 250	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(2)|lung(8)|skin(1)	15	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;2.53e-38)|OV - Ovarian serous cystadenocarcinoma(54;4.07e-38)|all cancers(56;2.27e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.0654)		CCCAGAATCACTGTTTGCTCT	0.393000													74	223					6.30617e-38	7.25209e-38	1	1	0
NXN	64359	broad.mit.edu	37	17	704350	704350	+	Nonsense_Mutation	SNP	G	G	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr17:704350G>A	ENST00000336868.3	-	8	1238	c.1147C>T	c.(1147-1149)Cga>Tga	p.R383*	NXN_ENST00000575801.1_Nonsense_Mutation_p.R275*|NXN_ENST00000538650.1_Nonsense_Mutation_p.R74*|NXN_ENST00000537628.2_Nonsense_Mutation_p.R134*	NM_022463.4	NP_071908.2	Q6DKJ4	NXN_HUMAN	nucleoredoxin	383					cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)		GTGTAATCTCGCAGGGAGTCA	0.582000													16	16					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													4	26					0	0	1	0	0
PARD3B	117583	broad.mit.edu	37	2	205989150	205989150	+	Missense_Mutation	SNP	T	T	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr2:205989150T>A	ENST00000406610.2	+	9	1472	c.1265T>A	c.(1264-1266)aTa>aAa	p.I422K	PARD3B_ENST00000358768.2_Missense_Mutation_p.I422K|PARD3B_ENST00000462231.1_Missense_Mutation_p.I422K|PARD3B_ENST00000351153.1_Missense_Mutation_p.I422K|PARD3B_ENST00000349953.3_Missense_Mutation_p.I422K	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	422	PDZ 2.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GGAGCAGCAATAAAAGATGGC	0.393000													12	98					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105160995	105160995	+	Missense_Mutation	SNP	C	C	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr8:105160995C>T	ENST00000436393.2	+	23	3548	c.3307C>T	c.(3307-3309)Cgc>Tgc	p.R1103C	RIMS2_ENST00000507740.1_Intron|RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000406091.3_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	531					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CAAAAAGCGGCGCTCTAGCCT	0.527000										HNSCC(12;0.0054)			20	84					0	0	1	0	0
PCDHA1	0	broad.mit.edu	37	5	140165935	140165935	+	Silent	SNP	C	C	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr5:140165935C>A	ENST00000504120.2	+	1	60	c.60C>A	c.(58-60)ctC>ctA	p.L20L	PCDHA1_ENST00000378133.3_Silent_p.L20L|PCDHA1_ENST00000394633.3_Silent_p.L20L	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTTCTGCTCCTCGCAGCCT	0.592000													6	111					3.59834e-05	3.59834e-05	1	1	0
TEKT4	150483	broad.mit.edu	37	2	95539305	95539305	+	Missense_Mutation	SNP	G	G	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr2:95539305G>A	ENST00000295201.4	+	2	676	c.539G>A	c.(538-540)aGa>aAa	p.R180K	AC097374.2_ENST00000568768.1_RNA	NM_144705.2	NP_653306.1	Q8WW24	TEKT4_HUMAN	tektin 4	180					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	28						CTGCTGAAGAGAACCATCATG	0.607000													16	24					0	0	1	0	0
GRIA1	0	broad.mit.edu	37	5	153144045	153144045	+	Silent	SNP	C	C	A			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr5:153144045C>A	ENST00000285900.5	+	12	2218	c.1875C>A	c.(1873-1875)atC>atA	p.I625I	GRIA1_ENST00000521843.2_Silent_p.I556I|GRIA1_ENST00000448073.4_Silent_p.I635I|GRIA1_ENST00000518142.1_Silent_p.I545I|GRIA1_ENST00000518783.1_Silent_p.I635I|GRIA1_ENST00000340592.5_Silent_p.I625I	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	625					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TCACCTTAATCATCATCTCCT	0.542000													24	40					1.10923e-09	1.15965e-09	1	1	0
NLGN3	54413	broad.mit.edu	37	X	70375183	70375183	+	Missense_Mutation	SNP	A	A	T			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chrX:70375183A>T	ENST00000374051.3	+	4	959	c.637A>T	c.(637-639)Atc>Ttc	p.I213F	NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000536169.1_Missense_Mutation_p.I193F|NLGN3_ENST00000358741.3_Missense_Mutation_p.I233F	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	233					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					TGTCATCGTCATCACCCTCAA	0.532000													4	47					0	0	1	0	0
TP53BP2	7159	broad.mit.edu	37	1	223986326	223986326	+	Frame_Shift_Del	DEL	T	T	-			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr1:223986326delT	ENST00000391878.2	-	13	1920	c.1152delA	c.(1150-1152)aafs	p.K384fs	TP53BP2_ENST00000498843.1_5'UTR|TP53BP2_ENST00000343537.7_Frame_Shift_Del_p.K513fs|TP53BP2_ENST00000391879.2_Intron	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	507					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		AATTAATCTGTTTTGGTTTTG	0.383													55	6	---	---	---	---					
KIAA2026	158358	broad.mit.edu	37	9	5968044	5968044	+	Frame_Shift_Del	DEL	T	T	-			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr9:5968044delT	ENST00000399933.3	-	3	2186	c.2187delA	c.(2185-2187)aafs	p.K729fs	KIAA2026_ENST00000381461.2_Frame_Shift_Del_p.K729fs	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	729	Lys-rich.							p.A730fs*15(1)		breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TGTGTTTTGCTTTTTTTTTGA	0.323													2	4	---	---	---	---					
HINT2	84681	broad.mit.edu	37	9	35813705	35813705	+	Frame_Shift_Del	DEL	G	G	-			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr9:35813705delG	ENST00000259667.5	-	2	199	c.158delC	c.(157-159)cafs	p.P53fs	HINT2_ENST00000474908.1_5'UTR	NM_032593.2	NP_115982.1	Q9BX68	HINT2_HUMAN	histidine triad nucleotide binding protein 2	53					apoptosis|steroid biosynthetic process	mitochondrion	hydrolase activity			NS(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	7	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)			GAAGATGGTTGGGGCTGCTCC	0.572											OREG0019179	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	22	---	---	---	---					
TLE4	7091	broad.mit.edu	37	9	82187726	82187727	+	Translation_Start_Site	INS	-	-	ATGT			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr9:82187726_82187727insATGT	ENST00000376534.4	+	0	187_188				TLE4_ENST00000376520.4_Frame_Shift_Ins_p.NV7fs|TLE4_ENST00000376544.3_Frame_Shift_Ins_p.NV7fs|TLE4_ENST00000376552.2_Frame_Shift_Ins_p.NV7fs|TLE4_ENST00000265284.6_Frame_Shift_Ins_p.NV7fs|TLE4_ENST00000376537.4_Frame_Shift_Ins_p.NV7fs			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)											breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						ACCTGAGCAAGATGTACCCGCA	0.683													9	28	---	---	---	---					
TPTEP1	0	broad.mit.edu	37	22	17131536	17131537	+	RNA	INS	-	-	CTG	rs34452519		TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr22:17131536_17131537insCTG	ENST00000426585.1	+	0	2562_2563																											TGCCCACTCTTCTGGTCTCATG	0.540													2	4	---	---	---	---					
SF3A1	10291	broad.mit.edu	37	22	30752730	30752730	+	Frame_Shift_Del	DEL	C	C	-			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chr22:30752730delC	ENST00000439242.1	-	1	183	c.52delG	c.(52-54)agfs	p.E18fs	CCDC157_ENST00000338306.3_5'UTR|SF3A1_ENST00000215793.7_Frame_Shift_Del_p.E18fs|CCDC157_ENST00000405659.1_5'UTR|CCDC157_ENST00000399824.2_5'UTR	NM_001005409.1	NP_001005409.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa	18					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						TGTTTGGGCTCCGTGGGCACG	0.721													2	4	---	---	---	---					
UXT	8409	broad.mit.edu	37	X	47511500	47511500	+	Frame_Shift_Del	DEL	G	G	-			TCGA-M7-A724-01A-12D-A32B-08	TCGA-M7-A724-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	da45f3a1-439a-45b0-8e3d-9761899018a9	ef22c980-b6f4-4ffc-a877-20515c382c67	g.chrX:47511500delG	ENST00000335890.2	-	5	589	c.436delC	c.(436-438)atfs	p.H146fs	UXT_ENST00000460840.1_5'UTR|UXT_ENST00000333119.3_Frame_Shift_Del_p.H134fs	NM_153477.2	NP_705582.1	Q9UBK9	UXT_HUMAN	ubiquitously-expressed, prefoldin-like chaperone	134					centrosome organization|mitochondrion transport along microtubule|protein folding	centrosome|nucleus|prefoldin complex	beta-tubulin binding|microtubule binding|unfolded protein binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(1)	6						ATGTGGATATGGGCTTTGATA	0.488													2	4	---	---	---	---