Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KRT72	140807	broad.mit.edu	37	12	52981595	52981595	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr12:52981595C>T	ENST00000293745.2	-	7	1215	c.1130G>A	c.(1129-1131)cGg>cAg	p.R377Q	KRT72_ENST00000354310.4_Missense_Mutation_p.R335Q|KRT72_ENST00000398066.3_Missense_Mutation_p.R189Q|KRT72_ENST00000537672.2_Missense_Mutation_p.R377Q	NM_080747.2	NP_542785.1	Q14CN4	K2C72_HUMAN	keratin 72	377	Coil 2.|Rod.					keratin filament	structural molecule activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(357;0.195)		GCAGTCCCCCCGCTGTTCAGC	0.627000													4	40					0	0	1	0	0
EFTUD2	9343	broad.mit.edu	37	17	42941093	42941093	+	Missense_Mutation	SNP	T	T	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr17:42941093T>C	ENST00000426333.2	-	15	1640	c.1343A>G	c.(1342-1344)aAg>aGg	p.K448R	EFTUD2_ENST00000592576.1_Missense_Mutation_p.K438R|EFTUD2_ENST00000591382.1_Missense_Mutation_p.K448R|EFTUD2_ENST00000402521.3_Missense_Mutation_p.K413R	NM_001142605.1|NM_001258354.1|NM_004247.3	NP_001136077.1|NP_001245283.1|NP_004238.3	Q15029	U5S1_HUMAN	elongation factor Tu GTP binding domain containing 2	448						Cajal body|catalytic step 2 spliceosome|cytoplasm|nuclear speck	GTP binding|GTPase activity|protein binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	32		Prostate(33;0.109)				GTGCTCAATCTTGGGCTTGGC	0.557000													7	59					0	0	1	0	0
SYDE2	84144	broad.mit.edu	37	1	85648608	85648608	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr1:85648608C>T	ENST00000341460.5	-	3	1766	c.1717G>A	c.(1717-1719)Gat>Aat	p.D573N		NM_032184.1	NP_115560.1	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2 (C. elegans)	573					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	20				all cancers(265;0.0126)|Epithelial(280;0.0336)		GGCAGAATATCAGTATGATGA	0.418000													38	74					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5068392	5068392	+	Missense_Mutation	SNP	G	G	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr11:5068392G>C	ENST00000380370.1	+	1	637	c.637G>C	c.(637-639)Gtg>Ctg	p.V213L		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCTGAACCTGGTGCTCATTGG	0.458000													4	114					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439449	150439449	+	Silent	SNP	C	C	T	rs142964864		TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr7:150439449C>T	ENST00000358647.3	+	3	589	c.222C>T	c.(220-222)aaC>aaT	p.N74N	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GAACATGGAACGGGAGGAAAG	0.572000													5	48					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37947800	37947800	+	Missense_Mutation	SNP	G	G	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr17:37947800G>C	ENST00000346872.3	-	5	522	c.461C>G	c.(460-462)tCt>tGt	p.S154C	IKZF3_ENST00000439167.2_Missense_Mutation_p.S120C|IKZF3_ENST00000439016.2_Intron|IKZF3_ENST00000394189.2_Intron|IKZF3_ENST00000377945.3_Intron|IKZF3_ENST00000377958.2_Missense_Mutation_p.S67C|IKZF3_ENST00000351680.3_Missense_Mutation_p.S154C|IKZF3_ENST00000377952.2_Intron|IKZF3_ENST00000350532.3_Missense_Mutation_p.S154C|IKZF3_ENST00000346243.3_Missense_Mutation_p.S154C|IKZF3_ENST00000535189.1_Missense_Mutation_p.S120C|IKZF3_ENST00000467757.1_Intron|IKZF3_ENST00000377944.3_Intron	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)	154					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CTGAGTAAAAGATGCCCCACA	0.433000													4	106					0	0	1	0	0
CDC42EP3	10602	broad.mit.edu	37	2	37873475	37873475	+	Missense_Mutation	SNP	G	G	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr2:37873475G>A	ENST00000295324.3	-	2	1256	c.256C>T	c.(256-258)Cgg>Tgg	p.R86W	AC006369.2_ENST00000419425.1_RNA	NM_001270436.1|NM_001270437.1|NM_001270438.1|NM_006449.3	NP_001257365.1|NP_001257366.1|NP_001257367.1|NP_006440.2	Q9UKI2	BORG2_HUMAN	CDC42 effector protein (Rho GTPase binding) 3	86					regulation of cell shape|signal transduction	actin cytoskeleton|cytoplasm|endomembrane system|membrane	cytoskeletal regulatory protein binding			endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	11		all_hematologic(82;0.172)				CTGTTGGCCCGGAAGAACTCA	0.527000													3	69					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201185718	201185718	+	Silent	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr1:201185718C>T	ENST00000335211.4	+	16	9562	c.9432C>T	c.(9430-9432)ggC>ggT	p.G3144G	IGFN1_ENST00000295591.8_Silent_p.G304G	NM_001164586.1	NP_001158058.1			immunoglobulin-like and fibronectin type III domain containing 1											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						GGCAGGCTGGCAGGAGCACTT	0.657000													5	19					0	0	1	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130766835	130766835	+	Silent	SNP	G	G	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr5:130766835G>T	ENST00000509018.1	-	26	4387	c.4182C>A	c.(4180-4182)acC>acA	p.T1394T	RAPGEF6_ENST00000307984.5_Silent_p.T1407T|RAPGEF6_ENST00000296859.6_Silent_p.T1402T|RAPGEF6_ENST00000507093.1_Silent_p.T1402T|FNIP1_ENST00000514667.1_Silent_p.T1444T	NM_001164386.1|NM_016340.5	NP_001157858.1|NP_057424.3	Q8TEU7	RPGF6_HUMAN	Rap guanine nucleotide exchange factor (GEF) 6	1394	Ser-rich.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|skin(1)|stomach(1)	31			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		CATCCAAATGGGTATGTCTGT	0.468000													7	63					8.12818e-05	8.7632e-05	1	1	0
TOB2	10766	broad.mit.edu	37	22	41832694	41832694	+	Missense_Mutation	SNP	A	A	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr22:41832694A>C	ENST00000327492.3	-	2	1362	c.656T>G	c.(655-657)aTg>aGg	p.M219R		NM_016272.3	NP_057356.1	Q14106	TOB2_HUMAN	transducer of ERBB2, 2	219					female gamete generation|negative regulation of cell proliferation	cytoplasm|nucleus				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10						TGAGCGGGCCATGCGAGGCTG	0.627000													3	13					0	0	1	0	0
ZMYM5	9205	broad.mit.edu	37	13	20398825	20398825	+	Missense_Mutation	SNP	T	T	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr13:20398825T>C	ENST00000337963.4	-	8	2066	c.1802A>G	c.(1801-1803)aAt>aGt	p.N601S		NM_001142684.1	NP_001136156.1	Q9UJ78	ZMYM5_HUMAN	zinc finger, MYM-type 5	601						nucleus	zinc ion binding			kidney(1)|large_intestine(5)|lung(9)	15		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		tttcagttgattttttccttc	0.333000													3	13					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6697481	6697481	+	Silent	SNP	G	G	A	rs137956083		TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr19:6697481G>A	ENST00000245907.6	-	21	2762	c.2670C>T	c.(2668-2670)ccC>ccT	p.P890P		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	890					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACGAGGACTTGGGGGGGATGG	0.572000													7	36					0	0	1	0	0
SMOC1	64093	broad.mit.edu	37	14	70420250	70420250	+	Splice_Site	SNP	G	G	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr14:70420250G>A	ENST00000381280.4	+	3	631		c.e3+1		SMOC1_ENST00000361956.3_Splice_Site	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1						cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		CTTTACCCAGGTGAGGCCTCG	0.617000													22	25					0	0	1	0	0
WDR88	126248	broad.mit.edu	37	19	33623274	33623274	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr19:33623274C>T	ENST00000361680.2	+	1	277	c.199C>T	c.(199-201)Cca>Tca	p.P67S	WDR88_ENST00000592765.1_Missense_Mutation_p.P67S|WDR88_ENST00000355868.3_Missense_Mutation_p.P67S			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	67										breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					GGACAGGGAACCACCACCGCA	0.652000													9	74					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40259951	40259951	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr15:40259951C>T	ENST00000263791.5	+	9	1467	c.1424C>T	c.(1423-1425)aCg>aTg	p.T475M	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.T475M|EIF2AK4_ENST00000559624.1_Missense_Mutation_p.T475M	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	475	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CCTTATAAAACGGGGAAGAAA	0.493000													23	48					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57076312	57076312	+	Silent	SNP	G	G	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr11:57076312G>A	ENST00000532437.1	-	5	4184	c.3873C>T	c.(3871-3873)gcC>gcT	p.A1291A	TNKS1BP1_ENST00000358252.3_Silent_p.A1291A			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1291	Acidic.|Gly-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CTGCCCCTGGGGCCATGTTTC	0.587000													34	69					0	0	1	0	0
SURF6	6838	broad.mit.edu	37	9	136198945	136198945	+	Silent	SNP	G	G	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr9:136198945G>A	ENST00000372022.4	-	5	1111	c.846C>T	c.(844-846)atC>atT	p.I282I	SURF6_ENST00000468290.1_5'UTR	NM_006753.4	NP_006744.2	O75683	SURF6_HUMAN	surfeit 6	282						granular component	DNA binding|RNA binding			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	12				OV - Ovarian serous cystadenocarcinoma(145;1.16e-06)|Epithelial(140;8.34e-06)|all cancers(34;7.08e-05)		CGTCGTCACGGATCTTCACGC	0.687000													8	61					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44641091	44641091	+	Silent	SNP	G	G	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr20:44641091G>A	ENST00000372330.3	+	8	1219	c.1200G>A	c.(1198-1200)gcG>gcA	p.A400A		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	400					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	TCGTGGCGGCGCATGAGTTCG	0.652000													3	64					0	0	1	0	0
QRFPR	84109	broad.mit.edu	37	4	122250475	122250475	+	Silent	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr4:122250475C>T	ENST00000394427.2	-	6	1701	c.1290G>A	c.(1288-1290)ggG>ggA	p.G430G	QRFPR_ENST00000334383.5_3'UTR	NM_198179.2	NP_937822.2	Q96P65	QRFPR_HUMAN	pyroglutamylated RFamide peptide receptor	430						plasma membrane	neuropeptide Y receptor activity			endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(2)|skin(3)|stomach(1)	28						ATAATTAATGCCCACTGTCTA	0.343000													13	36					0	0	1	0	0
ELMOD1	55531	broad.mit.edu	37	11	107535808	107535808	+	Missense_Mutation	SNP	T	T	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr11:107535808T>A	ENST00000265840.7	+	12	1155	c.890T>A	c.(889-891)aTg>aAg	p.M297K	ELMOD1_ENST00000531234.1_Missense_Mutation_p.M291K|ELMOD1_ENST00000443271.2_Missense_Mutation_p.M289K	NM_018712.3	NP_061182.3	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1	297	ELMO.				phagocytosis	cytoskeleton	GTPase activator activity			endometrium(2)|large_intestine(5)|liver(2)|lung(7)|pancreas(2)|prostate(1)	19		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)		ATGGACATAATGGAATTTAAT	0.433000													17	93					0	0	1	0	0
FAM86HP	0	broad.mit.edu	37	3	129821754	129821754	+	RNA	SNP	C	C	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr3:129821754C>A	ENST00000500074.2	-	0	391																											CAATACAGCACGTCTACGGTG	0.587000													3	44					0.00198382	0.00204304	1	1	0
SLC27A1	376497	broad.mit.edu	37	19	17608156	17608156	+	Silent	SNP	G	G	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr19:17608156G>A	ENST00000252595.7	+	7	1186	c.1089G>A	c.(1087-1089)ggG>ggA	p.G363G	SLC27A1_ENST00000442725.1_Silent_p.G363G|CTD-3131K8.2_ENST00000596643.1_lincRNA|SLC27A1_ENST00000598424.1_Silent_p.G184G	NM_198580.1	NP_940982.1	Q6PCB7	S27A1_HUMAN	solute carrier family 27 (fatty acid transporter), member 1	363	Sufficient for oligomerization (By similarity).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TGGCGGTGGGGAACGGGCTGC	0.667000													15	14					0	0	1	0	0
FAM83D	81610	broad.mit.edu	37	20	37581078	37581078	+	Missense_Mutation	SNP	A	A	G			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr20:37581078A>G	ENST00000217429.4	+	4	1804	c.1763A>G	c.(1762-1764)aAc>aGc	p.N588S		NM_030919.2	NP_112181.2	Q9H4H8	FA83D_HUMAN	family with sequence similarity 83, member D	558					cell division|mitosis	cytoplasm|spindle pole				endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)|stomach(1)	28		Myeloproliferative disorder(115;0.00878)				TTTACTGAAAACCACCTTGGC	0.458000													26	35					0	0	1	0	0
HARS	3035	broad.mit.edu	37	5	140054664	140054664	+	Missense_Mutation	SNP	G	G	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr5:140054664G>C	ENST00000504366.1	-	10	2861	c.1042C>G	c.(1042-1044)Cag>Gag	p.Q348E	HARS_ENST00000431330.2_Missense_Mutation_p.Q303E|HARS_ENST00000457527.2_Missense_Mutation_p.Q397E|HARS_ENST00000438307.2_Missense_Mutation_p.Q377E|HARS_ENST00000448240.1_Missense_Mutation_p.Q222E|HARS_ENST00000307633.3_Missense_Mutation_p.Q357E|HARS_ENST00000504156.1_Missense_Mutation_p.Q417E|HARS_ENST00000415192.2_Missense_Mutation_p.Q343E			P12081	SYHC_HUMAN	histidyl-tRNA synthetase	417					histidyl-tRNA aminoacylation	cytosol	ATP binding|histidine-tRNA ligase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	19			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		L-Histidine(DB00117)	AGCTTCTTCTGTGCAGATGCC	0.537000													22	27					0	0	1	0	0
CADM1	23705	broad.mit.edu	37	11	115080343	115080343	+	Silent	SNP	G	G	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr11:115080343G>T	ENST00000537058.1	-	8	1049	c.1029C>A	c.(1027-1029)acC>acA	p.T343T	CADM1_ENST00000537140.1_Intron|CADM1_ENST00000542447.2_Intron|CADM1_ENST00000452722.2_Silent_p.T343T|CADM1_ENST00000536727.1_Intron|CADM1_ENST00000331581.6_Silent_p.T343T			Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	343				PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding	p.T343T(5)		cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		tggtggtggtggttgttgtgg	0.433000													4	56					0.00909568	0.00922944	1	1	0
BMP15	9210	broad.mit.edu	37	X	50653913	50653913	+	Missense_Mutation	SNP	C	C	G			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chrX:50653913C>G	ENST00000252677.3	+	1	130	c.130C>G	c.(130-132)Ctg>Gtg	p.L44V		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	44					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					TACTTTGCCCCTGATTGAGGA	0.557000													6	0					0	0	1	0	0
STAMBPL1	57559	broad.mit.edu	37	10	90672939	90672939	+	Missense_Mutation	SNP	C	C	G			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr10:90672939C>G	ENST00000371927.3	+	6	1460	c.502C>G	c.(502-504)Cgc>Ggc	p.R168G	STAMBPL1_ENST00000371922.1_Missense_Mutation_p.R2G|STAMBPL1_ENST00000371924.1_Missense_Mutation_p.R168G|STAMBPL1_ENST00000371926.3_Missense_Mutation_p.R168G			Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	168							metal ion binding|metallopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(1)	11		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TGCTCAGATGCGCCAGCAGCA	0.443000													12	65					0	0	1	0	0
C19orf26	255057	broad.mit.edu	37	19	1235783	1235783	+	Silent	SNP	G	G	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr19:1235783G>A	ENST00000590083.1	-	3	532	c.240C>T	c.(238-240)ctC>ctT	p.L80L	C19orf26_ENST00000215376.6_Silent_p.L74L|C19orf26_ENST00000382477.2_Silent_p.L74L			Q8N350	DOS_HUMAN	chromosome 19 open reading frame 26	74						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCACCTGTTGAGGCGCTGGT	0.662000										HNSCC(14;0.022)			5	27					0	0	1	0	0
FANCM	57697	broad.mit.edu	37	14	45639819	45639819	+	Missense_Mutation	SNP	A	A	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr14:45639819A>T	ENST00000267430.5	+	12	2115	c.2030A>T	c.(2029-2031)gAt>gTt	p.D677V	FANCM_ENST00000542564.2_Missense_Mutation_p.D651V	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	677					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						CTAAAGAAAGATTGGTTCTTA	0.299000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				5	44					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058348	11058348	+	RNA	SNP	C	C	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr21:11058348C>A	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGAGAGAAATCTCTTTATAAA	0.343000													5	105					0.000602214	0.000629588	1	1	0
DHX38	9785	broad.mit.edu	37	16	72134479	72134479	+	Missense_Mutation	SNP	A	A	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr16:72134479A>C	ENST00000268482.3	+	9	1770	c.1261A>C	c.(1261-1263)Att>Ctt	p.I421L	DHX38_ENST00000536867.1_Intron	NM_014003.3	NP_054722.2	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	421					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				GGATGGGCGCATTGTCTTCAC	0.587000													13	30					0	0	1	0	0
BBS5	129880	broad.mit.edu	37	2	170349443	170349443	+	Missense_Mutation	SNP	A	A	G			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr2:170349443A>G	ENST00000295240.3	+	6	822	c.446A>G	c.(445-447)aAc>aGc	p.N149S	BBS5_ENST00000554017.1_Missense_Mutation_p.N149S|RP11-724O16.1_ENST00000513963.1_Missense_Mutation_p.N149S|BBS5_ENST00000392663.2_Missense_Mutation_p.N149S	NM_152384.2	NP_689597.1			Bardet-Biedl syndrome 5											endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						CTAATTCAGAACAAGCAACTA	0.313000									Bardet-Biedl syndrome				5	30					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55652923	55652923	+	Missense_Mutation	SNP	C	C	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr11:55652923C>A	ENST00000449290.2	+	2	111	c.19C>A	c.(19-21)Caa>Aaa	p.Q7K		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	7						intracellular	zinc ion binding										TGGAATCTTGCAAGTCTTCCA	0.478000													23	52					4.22769e-11	4.94425e-11	1	1	0
KRT24	192666	broad.mit.edu	37	17	38859719	38859719	+	Missense_Mutation	SNP	C	C	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr17:38859719C>A	ENST00000264651.2	-	1	283	c.227G>T	c.(226-228)gGt>gTt	p.G76V		NM_019016.2	NP_061889.2	Q2M2I5	K1C24_HUMAN	keratin 24	76	Gly-rich.|Head.					cytoplasm|intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00526)				TCCCCCAAAACCACCCCCTAC	0.602000													4	48					0.00024832	0.000263601	1	1	0
GNAI1	2770	broad.mit.edu	37	7	79818543	79818543	+	Missense_Mutation	SNP	G	G	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr7:79818543G>A	ENST00000351004.3	+	3	672	c.299G>A	c.(298-300)cGg>cAg	p.R100Q	GNAI1_ENST00000490206.1_3'UTR|GNAI1_ENST00000457358.2_Missense_Mutation_p.R48Q	NM_002069.5	NP_002060.4	P63096	GNAI1_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	100					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody|nucleus	G-protein beta/gamma-subunit complex binding|GTP binding|metabotropic serotonin receptor binding|signal transducer activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	19						GACTCAGCCCGGGCGGTAAGT	0.403000													5	38					0	0	1	0	0
ACVR1C	130399	broad.mit.edu	37	2	158397662	158397662	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr2:158397662C>T	ENST00000243349.7	-	7	1525	c.1165G>A	c.(1165-1167)Gct>Act	p.A389T	ACVR1C_ENST00000335450.7_Missense_Mutation_p.A309T|ACVR1C_ENST00000348328.5_Missense_Mutation_p.A232T|ACVR1C_ENST00000409680.3_Missense_Mutation_p.A339T	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	389	Protein kinase.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						TAGATGTCAGCTCGTTTGAAG	0.388000													12	65					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110495238	110495238	+	Silent	SNP	T	T	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr8:110495238T>C	ENST00000378402.5	+	57	9584	c.9480T>C	c.(9478-9480)ctT>ctC	p.L3160L		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3160	G8 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGCTGGATCTTCATGGAATTC	0.408000										HNSCC(38;0.096)			3	10					0	0	1	0	0
CSTF3	1479	broad.mit.edu	37	11	33129494	33129494	+	Missense_Mutation	SNP	T	T	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr11:33129494T>A	ENST00000323959.4	-	5	450	c.311A>T	c.(310-312)tAt>tTt	p.Y104F	CSTF3_ENST00000524827.1_Missense_Mutation_p.Y136F	NM_001326.2	NP_001317.1	Q12996	CSTF3_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	104					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|stomach(1)	19						ATATGAAAGATAACACTTCCA	0.338000													25	37					0	0	1	0	0
ZNF836	162962	broad.mit.edu	37	19	52663765	52663765	+	Missense_Mutation	SNP	A	A	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr19:52663765A>C	ENST00000322146.8	-	4	616	c.95T>G	c.(94-96)tTg>tGg	p.L32W	ZNF836_ENST00000597065.1_Missense_Mutation_p.L32W|CTC-471J1.8_ENST00000594362.1_RNA|ZNF836_ENST00000597252.1_Missense_Mutation_p.L32W	NM_001102657.1	NP_001096127.1	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						ATCCCAGTACAAAGCTTTCTG	0.433000													14	105					0	0	1	0	0
STAMBPL1	57559	broad.mit.edu	37	10	90672938	90672938	+	Missense_Mutation	SNP	G	G	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr10:90672938G>A	ENST00000371927.3	+	6	1459	c.501G>A	c.(499-501)atG>atA	p.M167I	STAMBPL1_ENST00000371922.1_Start_Codon_SNP_p.M1I|STAMBPL1_ENST00000371924.1_Missense_Mutation_p.M167I|STAMBPL1_ENST00000371926.3_Missense_Mutation_p.M167I			Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	167							metal ion binding|metallopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(1)	11		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		TTGCTCAGATGCGCCAGCAGC	0.443000													12	65					0	0	1	0	0
ITIH3	3699	broad.mit.edu	37	3	52840313	52840313	+	Silent	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr3:52840313C>T	ENST00000449956.2	+	18	1953	c.1947C>T	c.(1945-1947)gaC>gaT	p.D649D	ITIH3_ENST00000416872.2_Intron	NM_002217.3	NP_002208.3	Q06033	ITIH3_HUMAN	inter-alpha-trypsin inhibitor heavy chain 3	649					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(6)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		CACCAGTGGACGGGGATCCCC	0.582000													5	32					0	0	1	0	0
MECOM	2122	broad.mit.edu	37	3	168802820	168802820	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr3:168802820C>T	ENST00000464456.1	-	15	4206	c.3006G>A	c.(3004-3006)atG>atA	p.M1002I	MECOM_ENST00000460814.1_3'UTR|MECOM_ENST00000433243.2_Missense_Mutation_p.M1012I|MECOM_ENST00000392736.3_Missense_Mutation_p.M1011I|MECOM_ENST00000264674.3_Missense_Mutation_p.M1076I|MECOM_ENST00000472280.1_Missense_Mutation_p.M1012I|MECOM_ENST00000468789.1_Missense_Mutation_p.M1011I|MECOM_ENST00000494292.1_Missense_Mutation_p.M1190I	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						GTGACAGCATCATAGCATATG	0.453000													20	40					0	0	1	0	0
FBXO18	84893	broad.mit.edu	37	10	5966434	5966434	+	Missense_Mutation	SNP	G	G	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr10:5966434G>T	ENST00000379999.5	+	18	2816	c.2712G>T	c.(2710-2712)agG>agT	p.R904S	FBXO18_ENST00000379994.1_Intron|FBXO18_ENST00000397269.3_Missense_Mutation_p.R340S|FBXO18_ENST00000362091.4_Missense_Mutation_p.R853S	NM_032807.4	NP_116196.3	Q8NFZ0	FBX18_HUMAN	F-box protein, helicase, 18	853					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|breast(2)|kidney(2)|large_intestine(16)|lung(9)|ovary(2)|prostate(3)|skin(3)|stomach(1)	40						TGGTGCAAAGGATAGAAAAAT	0.458000													16	24					3.52763e-06	3.8636e-06	1	1	0
PLXNB1	5364	broad.mit.edu	37	3	48452351	48452351	+	Missense_Mutation	SNP	T	T	G			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr3:48452351T>G	ENST00000358536.4	-	29	5611	c.5342A>C	c.(5341-5343)aAg>aCg	p.K1781T	PLXNB1_ENST00000296440.6_Missense_Mutation_p.K1781T|PLXNB1_ENST00000358459.4_Missense_Mutation_p.K1598T|PLXNB1_ENST00000456774.1_Missense_Mutation_p.K1598T|PLXNB1_ENST00000448774.2_Missense_Mutation_p.K392T	NM_002673.4	NP_002664.2	O43157	PLXB1_HUMAN	plexin B1	1781					axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CATCTTCTCCTTTGCCTGGGA	0.612000													10	8					0	0	1	0	0
ZNF778	197320	broad.mit.edu	37	16	89294750	89294750	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr16:89294750C>T	ENST00000433976.2	+	6	2302	c.1970C>T	c.(1969-1971)tCc>tTc	p.S657F	ZNF778_ENST00000306502.6_Missense_Mutation_p.S615F|RP11-46C24.6_ENST00000563182.1_RNA	NM_001201407.1|NM_182531.3	NP_001188336.1|NP_872337.2	Q96MU6	ZN778_HUMAN	zinc finger protein 778	657					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|skin(2)	24				BRCA - Breast invasive adenocarcinoma(80;0.0269)		TTCCGTGCCTCCTCTCACCTG	0.428000													7	16					0	0	1	0	0
EPCAM	4072	broad.mit.edu	37	2	47606938	47606938	+	Missense_Mutation	SNP	A	A	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr2:47606938A>C	ENST00000263735.4	+	7	1046	c.688A>C	c.(688-690)Aaa>Caa	p.K230Q	EPCAM_ENST00000405271.1_Missense_Mutation_p.K258Q	NM_002354.2	NP_002345.2	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule	230					positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding	p.0?(2)|p.?(1)		endometrium(3)|large_intestine(1)|liver(2)|lung(7)|skin(1)|stomach(1)	15						TCATTCTAAGAAAATGGACCT	0.343000													26	35					0	0	1	0	0
REPS1	85021	broad.mit.edu	37	6	139262626	139262626	+	Splice_Site	SNP	C	C	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr6:139262626C>A	ENST00000450536.2	-	8	1555	c.980_splice	c.e8-1	p.W327_splice	REPS1_ENST00000258062.5_Splice_Site_p.W327_splice|REPS1_ENST00000415951.2_Splice_Site_p.W327_splice|REPS1_ENST00000367663.4_Splice_Site_p.W327_splice|REPS1_ENST00000409812.2_Splice_Site_p.W327_splice			Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	327	EF-hand.|EH 2.					coated pit|plasma membrane	calcium ion binding|SH3 domain binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(2)	19				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		CTGAGAGTTCCCTAGAAGATA	0.368000													19	35					1.01871e-10	1.17152e-10	1	1	0
KRT25	147183	broad.mit.edu	37	17	38907296	38907296	+	Silent	SNP	G	G	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr17:38907296G>A	ENST00000312150.4	-	5	927	c.867C>T	c.(865-867)gtC>gtT	p.V289V		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	289	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				TTGTGGCTCCGACATCCTCAG	0.483000													4	57					0	0	1	0	0
GLUD1	2746	broad.mit.edu	37	10	88818951	88818951	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr10:88818951C>T	ENST00000277865.4	-	10	1454	c.1358G>A	c.(1357-1359)cGt>cAt	p.R453H	GLUD1_ENST00000544149.1_Missense_Mutation_p.R320H|GLUD1_ENST00000537649.1_Missense_Mutation_p.R286H	NM_005271.3	NP_005262.1	P00367	DHE3_HUMAN	glutamate dehydrogenase 1	453					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(11)|prostate(1)	22					L-Glutamic Acid(DB00142)|NADH(DB00157)	GAAGGTCAAACGGCCATAGCT	0.403000													4	163					0	0	1	0	0
ZNF598	90850	broad.mit.edu	37	16	2049812	2049812	+	Missense_Mutation	SNP	C	C	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr16:2049812C>A	ENST00000563630.1	-	9	1815	c.1573G>T	c.(1573-1575)Gcc>Tcc	p.A525S	ZNF598_ENST00000562103.1_Missense_Mutation_p.A525S|ZNF598_ENST00000431526.1_Missense_Mutation_p.A580S			Q86UK7	ZN598_HUMAN	zinc finger protein 598	580						intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						TGGATGGAGGCCAGCCCCAGT	0.667000													6	10					2.0095e-06	2.23638e-06	1	1	0
TSN	7247	broad.mit.edu	37	2	122520661	122520661	+	Splice_Site	SNP	G	G	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr2:122520661G>C	ENST00000389682.3	+	5	700		c.e5+1		TSN_ENST00000498545.1_Splice_Site|TSN_ENST00000409193.1_Splice_Site|TSN_ENST00000536142.1_Intron	NM_001261401.1|NM_004622.2	NP_001248330.1|NP_004613.1	Q15631	TSN_HUMAN	translin						DNA recombination	cytoplasm|nucleus	sequence-specific DNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(3)|skin(1)	12		Ovarian(717;0.0563)|Prostate(154;0.116)				CAGTGAACTGGTAAGCTCAGT	0.378000													6	23					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10090686	10090686	+	Missense_Mutation	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr19:10090686C>T	ENST00000264828.3	-	36	2727	c.2642G>A	c.(2641-2643)gGg>gAg	p.G881E		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	881	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GCCCTTTGGCCCAGGGAATCC	0.607000													3	26					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47696688	47696688	+	Missense_Mutation	SNP	T	T	C			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr17:47696688T>C	ENST00000393331.3	-	6	730	c.260A>G	c.(259-261)tAc>tGc	p.Y87C	SPOP_ENST00000347630.2_Missense_Mutation_p.Y87C|SPOP_ENST00000393328.2_Missense_Mutation_p.Y87C|SPOP_ENST00000503676.1_Missense_Mutation_p.Y87C|SPOP_ENST00000504102.1_Missense_Mutation_p.Y87C|SPOP_ENST00000513080.1_5'UTR	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	87	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.Y87C(2)|p.Y87S(2)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						CAGTAACAGGTAAAGTGACAG	0.403000										Prostate(2;0.17)			32	34					0	0	1	0	0
IGHV1OR15-9	0	broad.mit.edu	37	15	20170312	20170312	+	RNA	SNP	C	C	A			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr15:20170312C>A	ENST00000338912.5	-	0	42																											ATCCTACCTGCAGCTATGACC	0.542000													45	53					5.13769e-22	6.11208e-22	1	1	0
AC008103.5	0	broad.mit.edu	37	22	18842438	18842438	+	RNA	SNP	G	G	A	rs9604886		TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr22:18842438G>A	ENST00000412938.1	+	0	2208																											TGGGGAAGAGGAGAGTGGCTC	0.627000													3	14					0	0	1	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428375	128428375	+	Silent	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr8:128428375C>T	ENST00000465342.2	+	2	1421	c.264C>T	c.(262-264)ggC>ggT	p.G88G	CASC8_ENST00000501396.1_RNA|CASC8_ENST00000523825.1_RNA|POU5F1B_ENST00000391675.1_Silent_p.G88G|CASC8_ENST00000502082.1_RNA			Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	88						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|prostate(1)|urinary_tract(1)	3						TGCCCCAAGGCGGCTTGGAGA	0.667000													9	26					0	0	1	0	0
RAB3C	115827	broad.mit.edu	37	5	57913607	57913607	+	Silent	SNP	C	C	T			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr5:57913607C>T	ENST00000282878.4	+	2	331	c.162C>T	c.(160-162)tcC>tcT	p.S54S		NM_138453.2	NP_612462.1	Q96E17	RAB3C_HUMAN	RAB3C, member RAS oncogene family	54					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)	21		all_cancers(5;9.93e-10)|all_epithelial(5;1.49e-10)|all_lung(5;8.97e-05)|Lung NSC(5;0.000139)|Prostate(74;0.0664)		OV - Ovarian serous cystadenocarcinoma(10;1.8e-34)		CAGATGACTCCTTTACATCTG	0.383000													6	18					0	0	1	0	0
RBM15	64783	broad.mit.edu	37	1	110883036	110883036	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr1:110883036delG	ENST00000369784.3	+	1	1909	c.1009delG	c.(1009-1011)agfs	p.E337fs	RBM15_ENST00000602849.1_Frame_Shift_Del_p.E337fs|RBM15_ENST00000487146.2_Frame_Shift_Del_p.E337fs	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	337					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCCGTTCTATGAGAGAGTGCG	0.582			T	MKL1	acute megakaryocytic leukemia								13	61	---	---	---	---					
MCC	4163	broad.mit.edu	37	5	112824048	112824049	+	In_Frame_Ins	INS	-	-	GCC	rs35336557		TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr5:112824048_112824049insGCC	ENST00000408903.3	-	1	478_479	c.63_64insGGC	c.(61-66)gggcgg>ggGGCgcgg	p.21_22GR>GAR		NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	549					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		ctgctgccgctgccgccgccgc	0.738													4	8	---	---	---	---					
MUC6	4588	broad.mit.edu	37	11	1017661	1017663	+	In_Frame_Del	DEL	TGT	TGT	-	rs72022620		TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr11:1017661_1017663delTGT	ENST00000421673.2	-	31	5188_5190	c.5138_5140delACA	c.(5137-5142)atc>a	p.NI1713del		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1713	Approximate repeats.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TTGGGGGTGATGTTGGTGGTAGA	0.527													12	505	---	---	---	---					
CMIP	80790	broad.mit.edu	37	16	81740629	81740630	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr16:81740629_81740630delTC	ENST00000537098.3	+	20	2280_2281	c.2208_2209delTC	c.(2206-2211)agtcfs	p.SL736fs	CMIP_ENST00000566513.1_3'UTR|CMIP_ENST00000539778.2_Frame_Shift_Del_p.SL642fs|CMIP_ENST00000398040.4_Frame_Shift_Del_p.SL583fs	NM_198390.2	NP_938204.2	Q8IY22	CMIP_HUMAN	c-Maf inducing protein	702						cytoplasm|nucleus				endometrium(5)|kidney(1)|lung(7)	13						CCATGAAGAGTCTCTGCAGTTT	0.515													20	141	---	---	---	---					
IFNGR2	3460	broad.mit.edu	37	21	34799292	34799292	+	Frame_Shift_Del	DEL	T	T	-			TCGA-TP-A8TV-01A-11D-A41K-08	TCGA-TP-A8TV-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f5e215fa-ef1d-4663-badb-152039afcbad	b6d5714c-04e4-4c50-aa90-47f20ab06b71	g.chr21:34799292delT	ENST00000290219.6	+	4	1162	c.514delT	c.(514-516)ttfs	p.F173fs	IFNGR2_ENST00000381995.1_Frame_Shift_Del_p.F192fs|IFNGR2_ENST00000405436.1_Frame_Shift_Del_p.F94fs	NM_005534.3	NP_005525.2	P38484	INGR2_HUMAN	interferon gamma receptor 2 (interferon gamma transducer 1)	173	Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	13					Interferon gamma-1b(DB00033)	CTCCACGGCCTTTTTTTGTTA	0.458													7	270	---	---	---	---