Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PPP1R16A	84988	broad.mit.edu	37	8	145726659	145726659	+	Silent	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr8:145726659C>T	ENST00000292539.4	+	10	2102	c.1185C>T	c.(1183-1185)ctC>ctT	p.L395L	PPP1R16A_ENST00000435887.1_Silent_p.L395L			Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory subunit 16A	395						plasma membrane	protein binding			NS(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			GCGCAGAGCTCAGGCCGCCGC	0.736000													4	10					0	0	1	0	0
GALNT3	2591	broad.mit.edu	37	2	166626873	166626873	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr2:166626873C>T	ENST00000392701.3	-	2	1113	c.338G>A	c.(337-339)cGt>cAt	p.R113H		NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	113					protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						CTGAGGTGGACGGTCAAGGAC	0.448000													8	83					0	0	1	0	0
LY6K	54742	broad.mit.edu	37	8	143781999	143781999	+	Silent	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr8:143781999C>T	ENST00000522591.1	+	1	110	c.54C>T	c.(52-54)gaC>gaT	p.D18D	LY6K_ENST00000292430.6_Silent_p.D18D|LY6K_ENST00000561179.1_Silent_p.D76D|LY6K_ENST00000518841.1_Silent_p.D18D|LY6K_ENST00000519387.1_Silent_p.D18D			Q17RY6	LY6K_HUMAN	lymphocyte antigen 6 complex, locus K	18						anchored to membrane|cytoplasm|extracellular region|nucleolus|plasma membrane				NS(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)	10	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGTGGACAGACGCCAACCTGA	0.721000													5	9					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35800721	35800721	+	Missense_Mutation	SNP	T	T	G			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr9:35800721T>G	ENST00000342694.2	+	6	1489	c.1234T>G	c.(1234-1236)Tcg>Gcg	p.S412A		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	412					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	AGCCCACTACTCGGGAGCTGA	0.617000													7	18					0	0	1	0	0
RPP30	10556	broad.mit.edu	37	10	92660334	92660334	+	Silent	SNP	A	A	G			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr10:92660334A>G	ENST00000413330.1	+	11	740	c.705A>G	c.(703-705)agA>agG	p.R235R	RPP30_ENST00000489806.1_3'UTR|RPP30_ENST00000371703.3_Silent_p.R235R	NM_001104546.1	NP_001098016.1	P78346	RPP30_HUMAN	ribonuclease P/MRP 30kDa subunit	235					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)	8						CAGAAACTAGAAAAACTGCTT	0.388000													41	88					0	0	1	0	0
DNM1L	10059	broad.mit.edu	37	12	32886660	32886660	+	Missense_Mutation	SNP	A	A	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr12:32886660A>T	ENST00000452533.2	+	13	1622	c.1458A>T	c.(1456-1458)ttA>ttT	p.L486F	DNM1L_ENST00000547312.1_Missense_Mutation_p.L486F|DNM1L_ENST00000414834.2_Missense_Mutation_p.L283F|YARS2_ENST00000551673.1_Intron|DNM1L_ENST00000381000.4_Missense_Mutation_p.L499F|DNM1L_ENST00000358214.5_Missense_Mutation_p.L499F|DNM1L_ENST00000266481.6_Missense_Mutation_p.L486F|DNM1L_ENST00000553257.1_Missense_Mutation_p.L499F|DNM1L_ENST00000549701.1_Missense_Mutation_p.L486F	NM_012062.3|NM_012063.2	NP_036192.2|NP_036193.2	O00429	DNM1L_HUMAN	dynamin 1-like	486	Interaction with GSK3B.|Middle domain.				cellular component disassembly involved in apoptosis|mitochondrial fragmentation involved in apoptosis|mitochondrial membrane organization|positive regulation of mitochondrial fission	cis-Golgi network|cytosol|endomembrane system|endoplasmic reticulum|mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	23	Lung NSC(5;2.15e-06)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TCCATAACTTAGTGGCAATTG	0.289000													17	169					0	0	1	0	0
DBF4B	80174	broad.mit.edu	37	17	42828594	42828594	+	Silent	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr17:42828594C>T	ENST00000315005.3	+	14	1959	c.1821C>T	c.(1819-1821)tgC>tgT	p.C607C	DBF4B_ENST00000393547.2_Intron	NM_145663.2	NP_663696.1	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B (S. cerevisiae)	607					cell cycle	nucleus	nucleic acid binding|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)	7		Prostate(33;0.0322)				TTCTCCATTGCGGCTTCCTGG	0.542000													5	46					0	0	1	0	0
TET3	200424	broad.mit.edu	37	2	74274785	74274785	+	Missense_Mutation	SNP	A	A	C			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr2:74274785A>C	ENST00000409262.3	+	1	1336	c.1336A>C	c.(1336-1338)Aag>Cag	p.K446Q		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	446							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GAAGAAGAAGAAGCTCCCAAC	0.597000													5	11					0	0	1	0	0
TGM6	343641	broad.mit.edu	37	20	2381056	2381056	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr20:2381056C>T	ENST00000202625.2	+	7	1016	c.955C>T	c.(955-957)Cgg>Tgg	p.R319W	TGM6_ENST00000381423.1_Missense_Mutation_p.R319W|TGM6_ENST00000477505.1_3'UTR	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	319					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	CTCCTTCGGGCGGACCCTGGA	0.617000													6	48					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47161880	47161880	+	Nonsense_Mutation	SNP	C	C	A			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr3:47161880C>A	ENST00000409792.3	-	3	4288	c.4246G>T	c.(4246-4248)Gaa>Taa	p.E1416*		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CCATCACTTTCAGAATCACTC	0.423000			"""N, F, S, Mis"""		clear cell renal carcinoma								16	36					1.15088e-07	1.25363e-07	1	1	0
NT5DC3	51559	broad.mit.edu	37	12	104186976	104186976	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr12:104186976C>T	ENST00000392876.3	-	9	1025	c.985G>A	c.(985-987)Gct>Act	p.A329T		NM_001031701.2	NP_001026871.1	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	329							hydrolase activity|metal ion binding			NS(1)|breast(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|ovary(2)|skin(1)|stomach(2)	30						GGCTTCTCAGCCTGAACAATG	0.428000													59	122					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													3	71					0	0	1	0	0
FOXA1	3169	broad.mit.edu	37	14	38061191	38061191	+	Missense_Mutation	SNP	G	G	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr14:38061191G>T	ENST00000250448.2	-	2	859	c.798C>A	c.(796-798)ttC>ttA	p.F266L	FOXA1_ENST00000545425.2_5'UTR|FOXA1_ENST00000540786.1_Missense_Mutation_p.F233L	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	266					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TCTCGCACTTGAAGCGCTTCT	0.726000													3	8					0.115264	0.119171	1	1	0
RPN2	6185	broad.mit.edu	37	20	35833198	35833198	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr20:35833198G>A	ENST00000237530.6	+	6	895	c.584G>A	c.(583-585)gGg>gAg	p.G195E	RPN2_ENST00000373622.5_Missense_Mutation_p.G163E	NM_002951.3	NP_002942.2	P04844	RPN2_HUMAN	ribophorin II	195					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|skin(2)|stomach(1)	24		Myeloproliferative disorder(115;0.00878)				GATGAACTCGGGGGCGTGTAT	0.483000													6	111					0	0	1	0	0
IL22RA2	0	broad.mit.edu	37	6	137476210	137476210	+	Missense_Mutation	SNP	G	G	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr6:137476210G>T	ENST00000296980.2	-	5	640	c.340C>A	c.(340-342)Caa>Aaa	p.Q114K	IL22RA2_ENST00000349184.4_Missense_Mutation_p.Q82K|IL22RA2_ENST00000339602.3_Missense_Mutation_p.Q82K	NM_052962.2	NP_443194.1	Q969J5	I22R2_HUMAN	interleukin 22 receptor, alpha 2	114	Fibronectin type-III 2.				regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	interleukin-22 receptor activity			endometrium(1)|large_intestine(1)|lung(3)	5	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000313)|OV - Ovarian serous cystadenocarcinoma(155;0.00407)		GAGAGTTCTTGAGTACCCCAA	0.473000													32	86					2.47316e-13	2.84646e-13	1	1	0
OR10AG1	282770	broad.mit.edu	37	11	55735784	55735784	+	Missense_Mutation	SNP	A	A	C			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr11:55735784A>C	ENST00000312345.2	-	1	206	c.156T>G	c.(154-156)ttT>ttG	p.F52L		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					TGCTAAGAAAAAAATACATGG	0.323000													19	37					0	0	1	0	0
GUCY1A2	2977	broad.mit.edu	37	11	106810741	106810741	+	Missense_Mutation	SNP	C	C	G			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr11:106810741C>G	ENST00000526355.1	-	4	1119	c.651G>C	c.(649-651)caG>caC	p.Q217H	GUCY1A2_ENST00000347596.2_Missense_Mutation_p.Q217H|GUCY1A2_ENST00000282249.2_Missense_Mutation_p.Q217H	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	217					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		CCAGAGTGGCCTGTTTTCCAA	0.463000													16	49					0	0	1	0	0
GPANK1	7918	broad.mit.edu	37	6	31630284	31630284	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr6:31630284C>T	ENST00000375906.1	-	4	1514	c.830G>A	c.(829-831)cGg>cAg	p.R277Q	GPANK1_ENST00000375900.4_Missense_Mutation_p.R277Q|GPANK1_ENST00000375896.4_Missense_Mutation_p.R277Q|GPANK1_ENST00000375895.2_Missense_Mutation_p.R277Q|GPANK1_ENST00000375893.2_Missense_Mutation_p.R277Q	NM_001199237.1	NP_001186166.1	O95872	GPAN1_HUMAN	G patch domain and ankyrin repeats 1	277	G-patch.					intracellular	nucleic acid binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(7)	12						GCCCTCACCCCGGGGTCCCAG	0.647000													11	17					0	0	1	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239847	5239847	+	Missense_Mutation	SNP	G	G	C			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr5:5239847G>C	ENST00000274181.7	+	16	2470	c.2332G>C	c.(2332-2334)Gaa>Caa	p.E778Q		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	778	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						CCGCATCTATGAAATGAACGT	0.483000													5	104					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133932	91133932	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chrX:91133932G>A	ENST00000373094.1	+	2	3538	c.2693G>A	c.(2692-2694)aGt>aAt	p.S898N	PCDH11X_ENST00000361655.2_Missense_Mutation_p.S898N|PCDH11X_ENST00000395337.2_Missense_Mutation_p.S898N|PCDH11X_ENST00000373097.1_Missense_Mutation_p.S898N|PCDH11X_ENST00000504220.1_Missense_Mutation_p.S898N|PCDH11X_ENST00000298274.8_Missense_Mutation_p.S898N|PCDH11X_ENST00000361724.1_Missense_Mutation_p.S898N|PCDH11X_ENST00000406881.1_Missense_Mutation_p.S898N|PCDH11X_ENST00000373088.1_Missense_Mutation_p.S898N	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	898					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GATGTTGACAGTGATGGAAAC	0.378000													21	20					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11190607	11190607	+	Silent	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr1:11190607C>T	ENST00000361445.4	-	39	5668	c.5592G>A	c.(5590-5592)ccG>ccA	p.P1864P	MTOR_ENST00000376838.1_Silent_p.P69P	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1864	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TCTTCTGCAGCGGCGATGGGG	0.582000													3	31					0	0	1	0	0
LCOR	84458	broad.mit.edu	37	10	98711871	98711871	+	Missense_Mutation	SNP	G	G	C			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr10:98711871G>C	ENST00000540664.1	+	7	793	c.250G>C	c.(250-252)Gat>Cat	p.D84H	LCOR_ENST00000371103.3_Missense_Mutation_p.D84H|LCOR_ENST00000498444.1_3'UTR|LCOR_ENST00000356016.3_Missense_Mutation_p.D84H|LCOR_ENST00000371097.4_Missense_Mutation_p.D84H	NM_001170765.1|NM_001170766.1	NP_001164236.1|NP_001164237.1			ligand dependent nuclear receptor corepressor											endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|urinary_tract(1)	13		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		CGGTGTACTTGATCTGTCCAC	0.438000													10	29					0	0	1	0	0
LRRC2	79442	broad.mit.edu	37	3	46586569	46586569	+	Silent	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr3:46586569C>T	ENST00000395905.3	-	3	692	c.300G>A	c.(298-300)gcG>gcA	p.A100A	LRRC2_ENST00000296144.3_Silent_p.A100A	NM_024512.4	NP_078788.2	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	100										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	17		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		CAAACACAAACGCACTGCTCC	0.552000													5	208					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128306873	128306873	+	Missense_Mutation	SNP	G	G	C			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr6:128306873G>C	ENST00000368227.3	-	23	3661	c.3295C>G	c.(3295-3297)Cat>Gat	p.H1099D	PTPRK_ENST00000368215.3_Missense_Mutation_p.H1081D|PTPRK_ENST00000368207.3_Missense_Mutation_p.H1114D|PTPRK_ENST00000368210.3_Missense_Mutation_p.H1100D|PTPRK_ENST00000368226.4_Missense_Mutation_p.H1082D|PTPRK_ENST00000368213.5_Missense_Mutation_p.H1088D|PTPRK_ENST00000532331.1_Missense_Mutation_p.H1104D			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1081	Tyrosine-protein phosphatase 1.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TACCTGCAATGTACAACGATG	0.473000													10	20					0	0	1	0	0
SHC3	53358	broad.mit.edu	37	9	91657077	91657077	+	Silent	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr9:91657077C>T	ENST00000375835.4	-	10	1530	c.1224G>A	c.(1222-1224)acG>acA	p.T408T	SHC3_ENST00000375830.1_5'UTR	NM_016848.5	NP_058544.3	Q92529	SHC3_HUMAN	SHC (Src homology 2 domain containing) transforming protein 3	408	CH1.				central nervous system development|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	protein binding|signal transducer activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|skin(3)	28						TCCCTTCTGGCGTGCTGTAGA	0.572000													19	64					0	0	1	0	0
PELI1	57162	broad.mit.edu	37	2	64323320	64323320	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr2:64323320G>A	ENST00000358912.4	-	6	1071	c.629C>T	c.(628-630)tCg>tTg	p.S210L		NM_020651.3	NP_065702.2	Q96FA3	PELI1_HUMAN	pellino E3 ubiquitin protein ligase 1	210					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	19						TCCACACACCGATATTTCTCT	0.418000													25	76					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414373	20414373	+	Silent	SNP	G	G	A			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr9:20414373G>A	ENST00000380338.4	-	5	757	c.471C>T	c.(469-471)agC>agT	p.S157S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S154S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	157	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S157S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.527000			T	MLL	ALL								4	53					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94674828	94674828	+	Missense_Mutation	SNP	T	T	G			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr14:94674828T>G	ENST00000304338.3	+	3	373	c.219T>G	c.(217-219)agT>agG	p.S73R	PPP4R4_ENST00000555690.1_3'UTR|PPP4R4_ENST00000328839.3_Missense_Mutation_p.S73R	NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	73						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						AAGGAACAAGTGTGATTGCAA	0.368000													4	17					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75561146	75561146	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr10:75561146C>T	ENST00000604729.1	+	26	5671	c.5374C>T	c.(5374-5376)Cgc>Tgc	p.R1792C	ZSWIM8_ENST00000604524.1_Missense_Mutation_p.R1613C|ZSWIM8_ENST00000603114.1_Missense_Mutation_p.R1754C|ZSWIM8_ENST00000605216.1_Missense_Mutation_p.R1795C|ZSWIM8_ENST00000398706.2_Missense_Mutation_p.R1800C|NDST2_ENST00000456638.1_5'UTR					zinc finger, SWIM-type containing 8																		CCGGAGTGCCCGCAGCGCCTT	0.582000													3	43					0	0	1	0	0
HIST2H2AC	8338	broad.mit.edu	37	1	149858550	149858550	+	Missense_Mutation	SNP	G	G	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr1:149858550G>T	ENST00000331380.2	+	1	26	c.26G>T	c.(25-27)gGc>gTc	p.G9V		NM_003517.2	NP_003508.1	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	9					nucleosome assembly	nucleosome|nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|ovary(1)|skin(1)	20	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			AAACAAGGAGGCAAGGCCCGC	0.567000													5	84					0.184627	0.184627	1	1	0
KAL1	3730	broad.mit.edu	37	X	8555966	8555966	+	Nonsense_Mutation	SNP	G	G	A			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chrX:8555966G>A	ENST00000262648.3	-	5	744	c.595C>T	c.(595-597)Cag>Tag	p.Q199*		NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	199	Fibronectin type-III 1.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						ACCTCCAGCTGTCCAGACTGC	0.423000													12	5					0	0	1	0	0
SLC2A3	6515	broad.mit.edu	37	12	8083194	8083194	+	Silent	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr12:8083194C>T	ENST00000075120.7	-	5	795	c.555G>A	c.(553-555)ccG>ccA	p.P185P		NM_006931.2	NP_008862.1	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 3	185					carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity	p.P185P(1)		central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(14)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				Kidney(36;0.0866)		CCAGTAGCAGCGGCCATAGCT	0.443000													4	77					0	0	1	0	0
PTPLAD2	401494	broad.mit.edu	37	9	21026653	21026653	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr9:21026653T>C	ENST00000495827.1	-	3	257	c.212A>G	c.(211-213)gAa>gGa	p.E71G	PTPLAD2_ENST00000488436.1_5'UTR|PTPLAD2_ENST00000513293.2_Missense_Mutation_p.E71G	NM_001010915.3	NP_001010915.2	Q5VWC8	HACD4_HUMAN	protein tyrosine phosphatase-like A domain containing 2	71					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	lyase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)	10				Lung(24;6.02e-14)|LUSC - Lung squamous cell carcinoma(38;1.29e-10)		GTGCAGCAGTTCCAGGAGAGA	0.378000													6	96					0	0	1	0	0
SHQ1	55164	broad.mit.edu	37	3	72873608	72873608	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr3:72873608T>C	ENST00000325599.8	-	6	833	c.694A>G	c.(694-696)Aag>Gag	p.K232E	SHQ1_ENST00000463369.1_Missense_Mutation_p.K204E	NM_018130.2	NP_060600.2	Q6PI26	SHQ1_HUMAN	SHQ1, H/ACA ribonucleoprotein assembly factor	232					ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		TCCTGACTCTTTTCCAAAAAG	0.353000													21	29					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43913641	43913641	+	Splice_Site	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr1:43913641C>T	ENST00000562955.1	+	67	9391	c.9392_splice	c.e67+1	p.R3131_splice	SZT2-AS1_ENST00000396885.2_RNA|SZT2_ENST00000372442.1_Splice_Site_p.R2289_splice	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	3188						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GCACGTTCTGCGGTCAGCAGA	0.582000													3	43					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120474878	120474878	+	Missense_Mutation	SNP	G	G	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr9:120474878G>T	ENST00000355622.6	+	3	573	c.472G>T	c.(472-474)Gct>Tct	p.A158S	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.A118S	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	158					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						ACTTAATGTGGCTCACAATCT	0.373000													12	39					0.010729	0.011284	1	1	0
ZNF653	115950	broad.mit.edu	37	19	11596494	11596494	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr19:11596494C>T	ENST00000293771.5	-	7	1683	c.1547G>A	c.(1546-1548)cGg>cAg	p.R516Q	CTC-398G3.6_ENST00000585656.1_Intron	NM_138783.3	NP_620138.2	Q96CK0	ZN653_HUMAN	zinc finger protein 653	516					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	17						CATGTGCCGCCGCAGGTGGTT	0.592000													5	53					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151165044	151165044	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr3:151165044T>C	ENST00000282466.3	-	4	2724	c.2725A>G	c.(2725-2727)Atg>Gtg	p.M909V		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	909					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CCTCTTCCCATCTGGTCAGAG	0.433000													9	177					0	0	1	0	0
OR7D2	162998	broad.mit.edu	37	19	9296635	9296635	+	Missense_Mutation	SNP	T	T	A			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr19:9296635T>A	ENST00000344248.2	+	1	357	c.178T>A	c.(178-180)Tac>Aac	p.Y60N		NM_175883.2	NP_787079.1	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D, member 2	60					regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	20						CACCCCCATGTACTTCTTCCT	0.537000													33	51					0	0	1	0	0
PVRL3	25945	broad.mit.edu	37	3	110845029	110845029	+	Splice_Site	SNP	A	A	G			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr3:110845029A>G	ENST00000485303.1	+	5	1192		c.e5-1		PVRL3_ENST00000493615.1_Splice_Site|PVRL3_ENST00000319792.3_Splice_Site	NM_001243286.1|NM_015480.2	NP_001230215.1|NP_056295.1	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3						adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(3)	19						TTTAAAATCTAGGTTGGATGG	0.294000													4	38					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152461140	152461140	+	Missense_Mutation	SNP	C	C	T	rs143049227		TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr6:152461140C>T	ENST00000367255.5	-	140	26004	c.25403G>A	c.(25402-25404)cGt>cAt	p.R8468H	SYNE1_ENST00000423061.1_Missense_Mutation_p.R8420H|SYNE1_ENST00000347037.5_5'UTR|SYNE1_ENST00000265368.4_Missense_Mutation_p.R8468H|SYNE1_ENST00000354674.4_Missense_Mutation_p.R646H|SYNE1_ENST00000448038.1_Missense_Mutation_p.R8420H|SYNE1_ENST00000341594.5_Missense_Mutation_p.R8080H|SYNE1_ENST00000539504.1_Missense_Mutation_p.R623H|SYNE1_ENST00000356820.4_Missense_Mutation_p.R2992H	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8468			R -> H (in a colorectal cancer sample; somatic mutation).		cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding	p.R8468H(5)		NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAGTTCCAGACGCTGGAGCTG	0.557000										HNSCC(10;0.0054)			11	54					0	0	1	0	0
VANGL2	57216	broad.mit.edu	37	1	160395042	160395042	+	Silent	SNP	A	A	G			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr1:160395042A>G	ENST00000368061.2	+	8	1914	c.1440A>G	c.(1438-1440)ttA>ttG	p.L480L		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	480					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane		p.L480F(1)		biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TTTTCCTCTTAAAACGCCAGG	0.527000													9	28					0	0	1	0	0
CDKN1B	1027	broad.mit.edu	37	12	12870888	12870888	+	Nonsense_Mutation	SNP	G	G	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr12:12870888G>T	ENST00000228872.4	+	1	831	c.115G>T	c.(115-117)Gaa>Taa	p.E39*	CDKN1B_ENST00000477087.1_Intron|CDKN1B_ENST00000396340.1_Nonsense_Mutation_p.E39*	NM_004064.3	NP_004055.1	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	39					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity	p.E39Q(1)		breast(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(5)	13		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		GGTGGACCACGAAGAGTTAAC	0.602000													5	70					4.096e-09	4.54284e-09	1	1	0
GRM3	0	broad.mit.edu	37	7	86415592	86415592	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr7:86415592C>T	ENST00000361669.2	+	3	1583	c.484C>T	c.(484-486)Cgg>Tgg	p.R162W	GRM3_ENST00000394720.2_Missense_Mutation_p.R160W|GRM3_ENST00000439827.1_Missense_Mutation_p.R162W|AC005009.2_ENST00000452471.1_RNA|AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Missense_Mutation_p.R34W	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	162					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AAACCTGCTGCGGCTCTTCCA	0.517000													16	137					0	0	1	0	0
C6orf70	0	broad.mit.edu	37	6	170156863	170156863	+	Missense_Mutation	SNP	C	C	G			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr6:170156863C>G	ENST00000588451.1	+	5	601	c.88C>G	c.(88-90)Ctt>Gtt	p.L30V	C6orf70_ENST00000392095.4_Missense_Mutation_p.L30V|C6orf70_ENST00000418781.3_Missense_Mutation_p.L156V|C6orf70_ENST00000366772.2_Missense_Mutation_p.L156V|C6orf70_ENST00000366773.3_Missense_Mutation_p.L156V			Q5T6L9	CF070_HUMAN		156						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(1)	20		Breast(66;5.08e-05)|Ovarian(120;0.208)		OV - Ovarian serous cystadenocarcinoma(33;1.2e-22)|BRCA - Breast invasive adenocarcinoma(81;1.49e-07)|GBM - Glioblastoma multiforme(31;0.00191)		AAGAGATCTGCTTTCATCTGA	0.358000													4	109					0	0	1	0	0
DDX60	55601	broad.mit.edu	37	4	169204662	169204662	+	Missense_Mutation	SNP	T	T	C			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr4:169204662T>C	ENST00000393743.3	-	13	1948	c.1657A>G	c.(1657-1659)Atc>Gtc	p.I553V		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	553							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		GTCACGATGATTTTCGAAGAG	0.348000													9	59					0	0	1	0	0
ZNF48	197407	broad.mit.edu	37	16	30410427	30410427	+	Nonstop_Mutation	SNP	G	G	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr16:30410427G>T	ENST00000320159.2	+	2	2232	c.1856G>T	c.(1855-1857)tGa>tTa	p.*619L		NM_001214906.1|NM_001214907.1|NM_001214909.1|NM_152652.2	NP_001201835.1|NP_001201836.1|NP_001201838.1|NP_689865.2	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(11)|ovary(2)|pancreas(1)|skin(1)	21						GGACTGGAATGACGCGGTCCA	0.642000													4	28					0.150653	0.153164	1	1	0
LSS	4047	broad.mit.edu	37	21	47641788	47641788	+	Missense_Mutation	SNP	C	C	T	rs142081800		TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr21:47641788C>T	ENST00000397728.3	-	5	608	c.530G>A	c.(529-531)cGg>cAg	p.R177Q	AP001469.5_ENST00000418029.1_RNA|LSS_ENST00000464357.1_5'UTR|LSS_ENST00000457828.2_Missense_Mutation_p.R97Q|LSS_ENST00000522411.1_Missense_Mutation_p.R166Q|LSS_ENST00000356396.4_Missense_Mutation_p.R177Q	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	177					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					AAGAATGTTCCGGGCTCGTAC	0.517000													16	32					0	0	1	0	0
RPL10A	4736	broad.mit.edu	37	6	35437188	35437188	+	Silent	SNP	T	T	A			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr6:35437188T>A	ENST00000322203.6	+	4	219	c.192T>A	c.(190-192)tcT>tcA	p.S64S	RPL10A_ENST00000467020.1_3'UTR	NM_007104.4	NP_009035.3	P62906	RL10A_HUMAN	ribosomal protein L10a	64					anatomical structure morphogenesis|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	RNA binding|structural constituent of ribosome			breast(1)|large_intestine(2)|ovary(1)	4						CTAAGTTCTCTGTGTGTGTCC	0.572000													12	27					0	0	1	0	0
TPD52L1	0	broad.mit.edu	37	6	125584048	125584048	+	Silent	SNP	C	C	G			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr6:125584048C>G	ENST00000534000.1	+	7	851	c.555C>G	c.(553-555)gcC>gcG	p.A185A	TPD52L1_ENST00000530868.1_3'UTR|TPD52L1_ENST00000368402.5_3'UTR|TPD52L1_ENST00000527711.1_Silent_p.A172A|TPD52L1_ENST00000532429.1_Silent_p.A156A|TPD52L1_ENST00000534199.1_3'UTR|TPD52L1_ENST00000368388.2_3'UTR|TPD52L1_ENST00000392482.2_3'UTR|TPD52L1_ENST00000528193.1_3'UTR|TPD52L1_ENST00000524679.1_3'UTR|TPD52L1_ENST00000304877.13_Silent_p.A190A	NM_003287.2	NP_003278.1	Q16890	TPD53_HUMAN	tumor protein D52-like 1	185					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|large_intestine(2)|prostate(1)	5			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		CGGCCCATGCCAGTGCCCAGA	0.577000													12	28					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656809	40656809	+	Missense_Mutation	SNP	G	G	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr2:40656809G>T	ENST00000406785.1	-	2	801	c.612C>A	c.(610-612)ttC>ttA	p.F204L	SLC8A1_ENST00000542756.1_Missense_Mutation_p.F204L|SLC8A1_ENST00000542024.1_Missense_Mutation_p.F204L|SLC8A1_ENST00000408028.2_Missense_Mutation_p.F204L|SLC8A1_ENST00000406391.2_Missense_Mutation_p.F204L|SLC8A1_ENST00000405901.3_Missense_Mutation_p.F204L|SLC8A1_ENST00000405269.1_Missense_Mutation_p.F204L|SLC8A1_ENST00000403092.1_Missense_Mutation_p.F204L|SLC8A1_ENST00000402441.1_Missense_Mutation_p.F204L|SLC8A1_ENST00000332839.4_Missense_Mutation_p.F204L			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	204					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CTGTCACAAAGAAGACACGCA	0.448000													13	23					6.72482e-11	7.59656e-11	1	1	0
NINL	22981	broad.mit.edu	37	20	25456887	25456887	+	Missense_Mutation	SNP	C	C	A			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr20:25456887C>A	ENST00000278886.6	-	17	3113	c.3040G>T	c.(3040-3042)Gtg>Ttg	p.V1014L	NINL_ENST00000422516.1_Intron	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	1014					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						GCAACCTCCACACTGTGCTTG	0.687000													5	69					1.23904e-05	1.32599e-05	1	1	0
TMCC2	9911	broad.mit.edu	37	1	205197784	205197784	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr1:205197784C>T	ENST00000358024.3	+	1	481	c.92C>T	c.(91-93)gCg>gTg	p.A31V		NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	31						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CTGCCGGGCGCGGACCTCCGG	0.672000													5	38					0	0	1	0	0
RANGAP1	5905	broad.mit.edu	37	22	41650402	41650402	+	Silent	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr22:41650402C>T	ENST00000455915.2	-	10	2639	c.1170G>A	c.(1168-1170)gaG>gaA	p.E390E	RANGAP1_ENST00000407260.4_Silent_p.E335E|RANGAP1_ENST00000356244.3_Silent_p.E390E|RANGAP1_ENST00000405486.1_Silent_p.E390E			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	390	Asp/Glu-rich (highly acidic).				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity	p.E390E(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						cctcctcctcctcttcttcct	0.562000													3	37					0	0	1	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12943195	12943195	+	Silent	SNP	A	A	G			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr1:12943195A>G	ENST00000235349.5	-	2	91	c.21T>C	c.(19-21)acT>acC	p.T7T		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	7										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTCTGGGTGGAGTCCAGATGC	0.562000													16	149					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34038130	34038130	+	Missense_Mutation	SNP	G	G	A			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr1:34038130G>A	ENST00000373381.4	-	50	7914	c.7738C>T	c.(7738-7740)Cgc>Tgc	p.R2580C		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2582	Sushi 15.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGGACATTGCGGTTGCTCCAT	0.592000													10	63					0	0	1	0	0
MIOS	54468	broad.mit.edu	37	7	7635987	7635987	+	Missense_Mutation	SNP	T	T	A			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr7:7635987T>A	ENST00000340080.4	+	11	2717	c.2296T>A	c.(2296-2298)Tca>Aca	p.S766T	MIOS_ENST00000405785.1_Missense_Mutation_p.S766T	NM_019005.3	NP_061878.3	Q9NXC5	MIO_HUMAN	missing oocyte, meiosis regulator, homolog (Drosophila)	766										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TGTGAGTGGCTCACCAACGAA	0.463000													22	60					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656834	40656834	+	Missense_Mutation	SNP	C	C	G			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr2:40656834C>G	ENST00000406785.1	-	2	776	c.587G>C	c.(586-588)aGg>aCg	p.R196T	SLC8A1_ENST00000542756.1_Missense_Mutation_p.R196T|SLC8A1_ENST00000542024.1_Missense_Mutation_p.R196T|SLC8A1_ENST00000408028.2_Missense_Mutation_p.R196T|SLC8A1_ENST00000406391.2_Missense_Mutation_p.R196T|SLC8A1_ENST00000405901.3_Missense_Mutation_p.R196T|SLC8A1_ENST00000405269.1_Missense_Mutation_p.R196T|SLC8A1_ENST00000403092.1_Missense_Mutation_p.R196T|SLC8A1_ENST00000402441.1_Missense_Mutation_p.R196T|SLC8A1_ENST00000332839.4_Missense_Mutation_p.R196T			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	196					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CTTAATCTTCCTTGTCTCTCC	0.463000													14	27					0	0	1	0	0
NAPSA	9476	broad.mit.edu	37	19	50862276	50862276	+	Missense_Mutation	SNP	C	C	T			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr19:50862276C>T	ENST00000253719.2	-	8	1235	c.1027G>A	c.(1027-1029)Gtc>Atc	p.V343I	NR1H2_ENST00000600978.1_Intron|NR1H2_ENST00000542413.1_Intron	NM_004851.1	NP_004842.1	O96009	NAPSA_HUMAN	napsin A aspartic peptidase	343					proteolysis	extracellular region	aspartic-type endopeptidase activity	p.V343I(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		ACCTGGATGACGTAATCATGG	0.557000													4	49					0	0	1	0	0
RP11-206L10.2	0	broad.mit.edu	37	1	700532	700532	+	RNA	DEL	T	T	-			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr1:700532delT	ENST00000428504.1	-	0	1021					NR_033908.1																						aaaaaaaaaaTTCCTTTGGGA	0.453													2	4	---	---	---	---					
ATP5F1	515	broad.mit.edu	37	1	111996955	111996955	+	Frame_Shift_Del	DEL	T	T	-			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr1:111996955delT	ENST00000369722.3	+	3	806	c.200delT	c.(199-201)ctfs	p.L67fs	ATP5F1_ENST00000369721.4_Intron|ATP5F1_ENST00000483994.1_Intron	NM_001688.4	NP_001679.2	P24539	AT5F1_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1	67					ATP catabolic process|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding			breast(1)|cervix(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	8		all_cancers(81;8.16e-06)|all_epithelial(167;5.63e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		TTCCAGTTTCTTTATCCTAAA	0.423													38	88	---	---	---	---					
GON4L	54856	broad.mit.edu	37	1	155735616	155735617	+	Frame_Shift_Ins	INS	-	-	G			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr1:155735616_155735617insG	ENST00000437809.1	-	21	3769_3770	c.3647_3648insC	c.(3646-3648)catfs	p.H1216fs	GON4L_ENST00000361040.5_Frame_Shift_Ins_p.H1216fs|GON4L_ENST00000271883.5_Frame_Shift_Ins_p.H1216fs|GON4L_ENST00000368331.1_Frame_Shift_Ins_p.H1216fs|GON4L_ENST00000471341.1_5'UTR			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1216					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TGGATGGTATAGGAAGATTCAC	0.490													16	42	---	---	---	---					
RFT1	91869	broad.mit.edu	37	3	53126551	53126551	+	Frame_Shift_Del	DEL	A	A	-			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr3:53126551delA	ENST00000296292.3	-	12	1353	c.1292delT	c.(1291-1293)tcfs	p.F431fs	RFT1_ENST00000394738.3_Frame_Shift_Del_p.F392fs|RP11-894J14.5_ENST00000607203.1_Intron	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	431					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		GGCCAAGATGAAGCCCACGCT	0.567													5	4	---	---	---	---					
WBP4	11193	broad.mit.edu	37	13	41654831	41654831	+	Frame_Shift_Del	DEL	A	A	-			TCGA-V1-A9OQ-01A-11D-A41K-08	TCGA-V1-A9OQ-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5b85059c-7e9e-4d42-a942-12cd919eea93	286b7dd0-24eb-48eb-b0f0-f9171d52b85a	g.chr13:41654831delA	ENST00000379487.3	+	9	1206	c.806delA	c.(805-807)gafs	p.E269fs	WBP4_ENST00000542082.1_Frame_Shift_Del_p.E248fs	NM_007187.3	NP_009118.1	O75554	WBP4_HUMAN	WW domain binding protein 4	269					nuclear mRNA cis splicing, via spliceosome	nuclear speck|spliceosomal complex	nucleic acid binding|proline-rich region binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|prostate(1)|skin(1)	12		Lung NSC(96;3.55e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;3.11e-09)|Epithelial(112;3.37e-06)|OV - Ovarian serous cystadenocarcinoma(117;8.3e-05)|GBM - Glioblastoma multiforme(144;0.00102)|BRCA - Breast invasive adenocarcinoma(63;0.07)		ACACAGAAAGAAAAAAGTATT	0.308													21	22	---	---	---	---