Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CT47B1	643311	broad.mit.edu	37	X	120009180	120009180	+	Silent	SNP	G	G	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chrX:120009180G>A	ENST00000371311.3	-	1	599	c.345C>T	c.(343-345)taC>taT	p.Y115Y		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	115										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						CCGCCGCCGGGTACCGACGGG	0.632000													10	6					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13381788	13381788	+	Missense_Mutation	SNP	G	G	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr3:13381788G>A	ENST00000254508.5	-	24	3321	c.3239C>T	c.(3238-3240)cCg>cTg	p.P1080L	NUP210_ENST00000485755.1_Intron	NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1080					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					CAGCCTGAACGGGGGAAAGAC	0.577000													16	23					0	0	1	0	0
PRRX1	5396	broad.mit.edu	37	1	170699464	170699464	+	Missense_Mutation	SNP	G	G	A	rs148536447		TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr1:170699464G>A	ENST00000367760.3	+	4	1731	c.646G>A	c.(646-648)Gga>Aga	p.G216R	PRRX1_ENST00000239461.6_Intron|PRRX1_ENST00000476867.2_Intron	NM_006902.3	NP_008833.1	P54821	PRRX1_HUMAN	paired related homeobox 1	0						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCTTCATAACGGATTCTAACG	0.453000													20	117					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73657756	73657756	+	Missense_Mutation	SNP	G	G	A	rs144715916		TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr3:73657756G>A	ENST00000263666.4	-	2	917	c.803C>T	c.(802-804)cCg>cTg	p.P268L	PDZRN3_ENST00000308537.4_Missense_Mutation_p.P268L	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	268	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TACCACACTCGGCCGGCCACC	0.473000													6	12					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156590429	156590429	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr5:156590429C>T	ENST00000302938.4	-	2	942	c.847G>A	c.(847-849)Gca>Aca	p.A283T		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	283	Ala-rich.					nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTGCTATTGCCACATCTGTT	0.582000													24	97					0	0	1	0	0
ZBTB7A	51341	broad.mit.edu	37	19	4054211	4054211	+	Missense_Mutation	SNP	C	C	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr19:4054211C>A	ENST00000322357.4	-	2	1298	c.1020G>T	c.(1018-1020)gaG>gaT	p.E340D	ZBTB7A_ENST00000601588.1_Missense_Mutation_p.E340D	NM_015898.2	NP_056982.1	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	340					cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	14		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCCCGCGACTCCTCGTCGC	0.706000													9	20					2.17888e-05	2.30338e-05	1	1	0
ZNF518B	85460	broad.mit.edu	37	4	10447287	10447287	+	Silent	SNP	G	G	C			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr4:10447287G>C	ENST00000326756.3	-	3	1104	c.666C>G	c.(664-666)gtC>gtG	p.V222V		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	222					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						CAACAGCTTTGACTGGCCGTT	0.413000													9	261					0	0	1	0	0
LILRB5	0	broad.mit.edu	37	19	54754843	54754843	+	Missense_Mutation	SNP	A	A	G			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr19:54754843A>G	ENST00000450632.1	-	13	1869	c.1792T>C	c.(1792-1794)Tcc>Ccc	p.S598P	LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000449561.2_Intron|LILRB5_ENST00000345866.6_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	423					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGGGGTGGGGAGGCCTGGGGG	0.607000													3	41					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72664015	72664015	+	RNA	SNP	C	C	G			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr7:72664015C>G	ENST00000425256.1	-	0	885					NR_002164.1																						ATACCACCCCCGGGGCATGCC	0.507000													3	13					0	0	1	0	0
PIWIL1	9271	broad.mit.edu	37	12	130840152	130840152	+	Missense_Mutation	SNP	C	C	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr12:130840152C>A	ENST00000245255.3	+	12	1616	c.1344C>A	c.(1342-1344)aaC>aaA	p.N448K		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	448					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		TTGATTCCAACTTACTGTCCT	0.388000													57	114					1.4709e-25	1.67456e-25	1	1	0
NSMCE4A	54780	broad.mit.edu	37	10	123720979	123720979	+	Missense_Mutation	SNP	G	G	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr10:123720979G>A	ENST00000538652.1	-	7	1058	c.421C>T	c.(421-423)Cgt>Tgt	p.R141C	NSMCE4A_ENST00000369023.3_Missense_Mutation_p.R300C|NSMCE4A_ENST00000489266.1_5'UTR			Q9NXX6	NSE4A_HUMAN	non-SMC element 4 homolog A (S. cerevisiae)	300										breast(2)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	6		all_neural(114;0.138)|Glioma(114;0.222)				TCCACTGTACGGGGGAAAGAA	0.313000													10	44					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49670145	49670145	+	Missense_Mutation	SNP	G	G	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr16:49670145G>A	ENST00000561648.1	-	4	2971	c.2918C>T	c.(2917-2919)aCg>aTg	p.T973M	ZNF423_ENST00000567169.1_Missense_Mutation_p.T856M|ZNF423_ENST00000562520.1_Missense_Mutation_p.T913M|ZNF423_ENST00000262383.2_Missense_Mutation_p.T973M|ZNF423_ENST00000563137.2_Missense_Mutation_p.T913M|ZNF423_ENST00000535559.1_Missense_Mutation_p.T856M|ZNF423_ENST00000562871.1_Missense_Mutation_p.T913M	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	973					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.T973M(2)		breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				TTCGGTGAGCGTCAGCAGCGA	0.612000													5	44					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664115	22664115	+	RNA	SNP	A	A	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr22:22664115A>T	ENST00000426066.1	+	0	638					NR_027293.1																						TGTTTAATTCAGCCTTGGAAG	0.413000													4	57					0	0	1	0	0
PTK7	0	broad.mit.edu	37	6	43112201	43112201	+	Missense_Mutation	SNP	A	A	G			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr6:43112201A>G	ENST00000230419.4	+	15	2485	c.2264A>G	c.(2263-2265)cAg>cGg	p.Q755R	PTK7_ENST00000481273.1_Missense_Mutation_p.Q763R|PTK7_ENST00000352931.2_Missense_Mutation_p.Q699R|PTK7_ENST00000349241.2_Missense_Mutation_p.Q625R|PTK7_ENST00000345201.2_Missense_Mutation_p.Q715R	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	755					actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GGGCCTTTGCAGAACGGGCAG	0.592000													11	62					0	0	1	0	0
KIAA1462	57608	broad.mit.edu	37	10	30306821	30306821	+	Missense_Mutation	SNP	C	C	G			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr10:30306821C>G	ENST00000375377.1	-	4	4172	c.4071G>C	c.(4069-4071)gaG>gaC	p.E1357D		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	1357										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ATCACACCCTCTCCACTCTGC	0.408000													11	32					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173832003	173832003	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr2:173832003C>T	ENST00000264111.6	+	10	1019	c.832C>T	c.(832-834)Cat>Tat	p.H278Y	RAPGEF4_ENST00000538974.1_Missense_Mutation_p.H108Y|RAPGEF4_ENST00000535187.1_Missense_Mutation_p.H59Y|RAPGEF4_ENST00000540783.1_Missense_Mutation_p.H126Y|RAPGEF4_ENST00000539331.1_Missense_Mutation_p.H126Y|RAPGEF4_ENST00000397081.3_Missense_Mutation_p.H279Y|RAPGEF4_ENST00000397087.3_Missense_Mutation_p.H135Y|RAPGEF4_ENST00000473043.1_3'UTR|RAPGEF4_ENST00000409036.1_Missense_Mutation_p.H279Y			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	279	DEP.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CCAGGAGCACCATTTCCAAGA	0.493000													7	13					0	0	1	0	0
NT5E	4907	broad.mit.edu	37	6	86195049	86195049	+	Missense_Mutation	SNP	T	T	G			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr6:86195049T>G	ENST00000257770.3	+	4	897	c.848T>G	c.(847-849)tTt>tGt	p.F283C	NT5E_ENST00000369651.3_Missense_Mutation_p.F283C	NM_002526.3	NP_002517.1	P21589	5NTD_HUMAN	5'-nucleotidase, ecto (CD73)	283					DNA metabolic process|purine base metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	5'-nucleotidase activity|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;0.000215)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0427)		BRCA - Breast invasive adenocarcinoma(108;0.0417)	Pentoxifylline(DB00806)	GCCTATGCTTTTGGCAAATAC	0.468000													43	45					0	0	1	0	0
PPP2R2B	5521	broad.mit.edu	37	5	146080619	146080619	+	Nonsense_Mutation	SNP	G	G	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr5:146080619G>A	ENST00000394413.3	-	2	727	c.157C>T	c.(157-159)Cga>Tga	p.R53*	PPP2R2B_ENST00000394411.4_Nonsense_Mutation_p.R53*|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000336640.6_Nonsense_Mutation_p.R56*|PPP2R2B_ENST00000394414.1_Nonsense_Mutation_p.R119*|PPP2R2B_ENST00000453001.1_Nonsense_Mutation_p.R53*|PPP2R2B_ENST00000504198.1_Nonsense_Mutation_p.R59*|PPP2R2B_ENST00000508545.2_Nonsense_Mutation_p.R42*|PPP2R2B_ENST00000394410.2_Nonsense_Mutation_p.R42*|PPP2R2B_ENST00000356826.3_Nonsense_Mutation_p.R53*|PPP2R2B_ENST00000394409.3_Nonsense_Mutation_p.R111*			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	53					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCTGCTCTCGTTGAAATATT	0.453000													97	313					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54847665	54847665	+	Silent	SNP	G	G	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr15:54847665G>A	ENST00000545554.1	+	28	5913	c.5913G>A	c.(5911-5913)acG>acA	p.T1971T	UNC13C_ENST00000537900.1_Silent_p.T1969T|UNC13C_ENST00000260323.11_Silent_p.T1971T			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1971	MHD2.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGGGTCTGACGCCAAGACAAT	0.438000													7	2					0	0	1	0	0
DBC1	0	broad.mit.edu	37	9	121930373	121930373	+	Silent	SNP	G	G	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr9:121930373G>A	ENST00000265922.3	-	8	1736	c.1275C>T	c.(1273-1275)ccC>ccT	p.P425P	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		425					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CGCAGGGGATGGGGCGCTGGC	0.607000													7	13					0	0	1	0	0
VAV3	10451	broad.mit.edu	37	1	108417551	108417551	+	Missense_Mutation	SNP	T	T	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr1:108417551T>A	ENST00000370056.4	-	2	567	c.293A>T	c.(292-294)gAc>gTc	p.D98V	VAV3_ENST00000527011.1_Missense_Mutation_p.D98V|VAV3_ENST00000371846.4_Missense_Mutation_p.D33V	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	98	CH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		ATCAAACAAGTCAAATGCCTC	0.353000													20	30					0	0	1	0	0
PHYHIP	9796	broad.mit.edu	37	8	22079251	22079251	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr8:22079251C>T	ENST00000454243.2	-	5	1182	c.608G>A	c.(607-609)cGc>cAc	p.R203H	PHYHIP_ENST00000321613.3_Missense_Mutation_p.R203H	NM_014759.3	NP_055574.3	Q92561	PHYIP_HUMAN	phytanoyl-CoA 2-hydroxylase interacting protein	203										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	10				Colorectal(74;0.0152)|COAD - Colon adenocarcinoma(73;0.0629)		GAAGCGCCAGCGGCCGTAGGG	0.627000													5	8					0	0	1	0	0
PCDHGB2	0	broad.mit.edu	37	5	140741286	140741286	+	Silent	SNP	C	C	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr5:140741286C>T	ENST00000522605.1	+	1	1584	c.1584C>T	c.(1582-1584)ttC>ttT	p.F528F	PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGCGCCTTCGAGCTCACAC	0.667000													4	67					0	0	1	0	0
RANBP6	26953	broad.mit.edu	37	9	6013361	6013361	+	Nonsense_Mutation	SNP	A	A	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr9:6013361A>T	ENST00000259569.5	-	1	2257	c.2247T>A	c.(2245-2247)taT>taA	p.Y749*		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	749					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		TCTGTGCAAGATACTCTGGGC	0.413000													11	87					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43926933	43926933	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr2:43926933C>T	ENST00000282406.4	+	8	946	c.836C>T	c.(835-837)tCt>tTt	p.S279F		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	279						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TCCCAGAATTCTGGGGCTCCT	0.512000													15	56					0	0	1	0	0
TMF1	7110	broad.mit.edu	37	3	69087802	69087802	+	Silent	SNP	A	A	C			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr3:69087802A>C	ENST00000543976.1	-	8	2319	c.2073T>G	c.(2071-2073)cgT>cgG	p.R691R	CTD-2013N24.2_ENST00000597950.1_RNA|CTD-2013N24.2_ENST00000596732.1_RNA|CTD-2013N24.2_ENST00000482368.2_RNA|CTD-2013N24.2_ENST00000601735.1_RNA|CTD-2013N24.2_ENST00000598783.1_RNA|TMF1_ENST00000398559.2_Silent_p.R688R|CTD-2013N24.2_ENST00000595925.1_RNA|CTD-2013N24.2_ENST00000596523.1_RNA|CTD-2013N24.2_ENST00000596274.1_RNA	NM_007114.2	NP_009045.2	P82094	TMF1_HUMAN	TATA element modulatory factor 1	688					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		CTTTCATTTCACGGCTCAGAG	0.403000													52	64					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4119141	4119141	+	Silent	SNP	T	T	G			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr7:4119141T>G	ENST00000404826.2	+	22	3388	c.3249T>G	c.(3247-3249)ccT>ccG	p.P1083P	SDK1_ENST00000389531.3_Silent_p.P1083P	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1083	Fibronectin type-III 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		ACATCAGCCCTCGCTCCGCCA	0.567000													27	123					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2039776	2039776	+	Silent	SNP	A	A	G	rs13296987	byFrequency	TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr9:2039776A>G	ENST00000382203.1	+	4	875	c.666A>G	c.(664-666)caA>caG	p.Q222Q	SMARCA2_ENST00000357248.2_Silent_p.Q222Q|SMARCA2_ENST00000382194.1_Silent_p.Q222Q|SMARCA2_ENST00000349721.2_Silent_p.Q222Q|SMARCA2_ENST00000491574.1_3'UTR			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	222	Poly-Gln.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		agcagcagcaacagcagcagc	0.637000													3	38					0	0	1	0	0
SLC26A11	284129	broad.mit.edu	37	17	78222020	78222020	+	Silent	SNP	C	C	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr17:78222020C>T	ENST00000361193.3	+	14	1666	c.1386C>T	c.(1384-1386)ctC>ctT	p.L462L	SLC26A11_ENST00000546047.2_Silent_p.L462L|SLC26A11_ENST00000411502.3_Silent_p.L462L|SLC26A11_ENST00000572725.1_Silent_p.L462L	NM_001166347.1|NM_173626.3	NP_001159819.1|NP_775897.3	Q86WA9	S2611_HUMAN	solute carrier family 26 (anion exchanger), member 11	462						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|plasma membrane	anion:anion antiporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	28	all_neural(118;0.0538)		OV - Ovarian serous cystadenocarcinoma(97;0.0344)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TGTCTCTGCTCATGCTCCTGC	0.637000													8	11					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520257	131520257	+	Silent	SNP	G	G	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr2:131520257G>T	ENST00000423981.1	+	2	722	c.612G>T	c.(610-612)ccG>ccT	p.P204P	AMER3_ENST00000321420.4_Silent_p.P204P	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		TCCTCCCCCCGGGTGAGGGGC	0.701000													16	31					1.5739e-10	1.71277e-10	1	1	0
TGM7	116179	broad.mit.edu	37	15	43571977	43571977	+	Silent	SNP	C	C	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr15:43571977C>A	ENST00000452443.2	-	10	1528	c.1524G>T	c.(1522-1524)ctG>ctT	p.L508L		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	508					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	TACGCAGCAGCAGCTGCAGGT	0.657000													5	50					3.59834e-05	3.75038e-05	1	1	0
UNC79	57578	broad.mit.edu	37	14	93994973	93994973	+	Missense_Mutation	SNP	T	T	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr14:93994973T>A	ENST00000553484.1	+	9	1187	c.1033T>A	c.(1033-1035)Tgc>Agc	p.C345S	UNC79_ENST00000256339.4_Missense_Mutation_p.C168S|UNC79_ENST00000393151.2_Missense_Mutation_p.C345S|UNC79_ENST00000555664.1_Missense_Mutation_p.C345S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	345						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CTGTGAAGAATGCAGCGAGAG	0.378000													44	58					0	0	1	0	0
SDAD1P1	0	broad.mit.edu	37	8	26237669	26237669	+	RNA	SNP	A	A	G			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr8:26237669A>G	ENST00000519902.1	-	0	2279																											TCAAAGTTCTAGCAGACATCA	0.443000													9	50					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152282534	152282534	+	Missense_Mutation	SNP	G	G	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr1:152282534G>A	ENST00000368799.1	-	3	4863	c.4828C>T	c.(4828-4830)Cgg>Tgg	p.R1610W	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1610	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTCAGACCGCCTCTCAGAG	0.572000									Ichthyosis				9	258					0	0	1	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129870588	129870588	+	Silent	SNP	G	G	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr9:129870588G>T	ENST00000373425.3	-	2	1040	c.423C>A	c.(421-423)ctC>ctA	p.L141L	RALGPS1_ENST00000373436.1_Intron|RALGPS1_ENST00000373434.1_Intron|ANGPTL2_ENST00000373417.1_Intron|RALGPS1_ENST00000394022.3_Intron|RALGPS1_ENST00000259351.5_Intron|RALGPS1_ENST00000424082.2_Intron	NM_012098.2	NP_036230.1	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2	141					multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						TCTCGTGCAGGAGCTGCATGT	0.617000													28	28					1.39806e-14	1.54412e-14	1	1	0
DHX33	56919	broad.mit.edu	37	17	5353605	5353605	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr17:5353605C>T	ENST00000225296.3	-	10	1846	c.1646G>A	c.(1645-1647)cGc>cAc	p.R549H	DHX33_ENST00000433302.3_Missense_Mutation_p.R325H	NM_001199699.1|NM_020162.3	NP_001186628.1|NP_064547.2	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	549						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GAACTTCTTGCGGACCCCTTG	0.537000													16	117					0	0	1	0	0
IPPK	64768	broad.mit.edu	37	9	95378253	95378253	+	Missense_Mutation	SNP	T	T	C			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr9:95378253T>C	ENST00000287996.3	-	13	1613	c.1337A>G	c.(1336-1338)gAg>gGg	p.E446G	IPPK_ENST00000375522.1_Missense_Mutation_p.E118G|IPPK_ENST00000486841.1_5'UTR|CENPP_ENST00000375587.3_3'UTR	NM_022755.5	NP_073592.1	Q9H8X2	IPPK_HUMAN	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	446					inositol or phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol pentakisphosphate 2-kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(2)|urinary_tract(1)	15						GGGAATGCTCTCGTAGGGCTT	0.498000													6	39					0	0	1	0	0
DLK1	8788	broad.mit.edu	37	14	101194764	101194764	+	Missense_Mutation	SNP	A	A	T	rs13329039	byFrequency	TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr14:101194764A>T	ENST00000341267.4	+	2	341	c.99A>T	c.(97-99)caA>caT	p.Q33H	DLK1_ENST00000556051.1_Missense_Mutation_p.Q33H|DLK1_ENST00000331224.6_Missense_Mutation_p.Q33H	NM_003836.5	NP_003827.3	P80370	DLK1_HUMAN	delta-like 1 homolog (Drosophila)	33	EGF-like 1.				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(16)|ovary(2)|prostate(1)|skin(1)	29		Melanoma(154;0.155)				GCAACCCCCAAAATGGATTCT	0.562000													13	47					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26640135	26640135	+	Missense_Mutation	SNP	A	A	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr12:26640135A>T	ENST00000381340.3	-	40	5836	c.5420T>A	c.(5419-5421)tTt>tAt	p.F1807Y		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	1807					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					GAGAACTTTAAAGAATTTTTC	0.343000													7	69					0	0	1	0	0
RNF214	257160	broad.mit.edu	37	11	117152031	117152031	+	Splice_Site	SNP	T	T	C			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr11:117152031T>C	ENST00000530849.1	+	8	692	c.680_splice	c.e8-1	p.S228_splice	RNF214_ENST00000531287.1_Splice_Site_p.S228_splice|RNF214_ENST00000531452.1_Splice_Site_p.S383_splice|RNF214_ENST00000300650.4_Splice_Site_p.S383_splice			Q8ND24	RN214_HUMAN	ring finger protein 214	383							zinc ion binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		TCTTGAAAGGTCAACTCCCCC	0.473000													7	33					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125192103	125192103	+	Missense_Mutation	SNP	A	A	G			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr2:125192103A>G	ENST00000431078.1	+	5	936	c.572A>G	c.(571-573)tAc>tGc	p.Y191C		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	191	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCACTTCTGTACAGGTTCAAT	0.448000													13	63					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	T	C			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr22:18844763T>C	ENST00000412938.1	+	0	3013																											TCACAGCCTCTGAGGGCAGCA	0.562000													4	17					0	0	1	0	0
ASIC1	41	broad.mit.edu	37	12	50473744	50473744	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr12:50473744C>T	ENST00000228468.4	+	8	1496	c.1111C>T	c.(1111-1113)Cgc>Tgc	p.R371C	ASIC1_ENST00000552438.1_Missense_Mutation_p.R405C|ASIC1_ENST00000447966.2_Missense_Mutation_p.R371C	NM_020039.3	NP_064423.2	P78348	ACCN2_HUMAN	acid-sensing (proton-gated) ion channel 1	371					calcium ion transport|response to pH|signal transduction	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	CAACCTGACCCGCTATGGCAA	0.532000													4	115					0	0	1	0	0
SORBS1	10580	broad.mit.edu	37	10	97074853	97074853	+	Missense_Mutation	SNP	G	G	C			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr10:97074853G>C	ENST00000371247.2	-	33	4031	c.3842C>G	c.(3841-3843)aCt>aGt	p.T1281S	SORBS1_ENST00000371239.1_Missense_Mutation_p.T800S|SORBS1_ENST00000353505.5_Missense_Mutation_p.T894S|SORBS1_ENST00000277982.5_Missense_Mutation_p.T1140S|SORBS1_ENST00000393949.1_Missense_Mutation_p.T993S|SORBS1_ENST00000354106.3_Missense_Mutation_p.T993S|SORBS1_ENST00000347291.4_Missense_Mutation_p.T835S|SORBS1_ENST00000306402.6_Missense_Mutation_p.T770S|SORBS1_ENST00000371249.2_Missense_Mutation_p.T805S|SORBS1_ENST00000371241.1_Missense_Mutation_p.T673S|SORBS1_ENST00000371227.4_Missense_Mutation_p.T1255S|SORBS1_ENST00000371245.3_Missense_Mutation_p.T894S|SORBS1_ENST00000371246.2_Missense_Mutation_p.T1140S|SORBS1_ENST00000607232.1_Missense_Mutation_p.T1283S|SORBS1_ENST00000361941.3_Missense_Mutation_p.T1281S			Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1	1281	SH3 3.				focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(19)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GCCTGGAAAAGTACCAAACTG	0.393000													19	36					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114069639	114069639	+	Missense_Mutation	SNP	C	C	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr3:114069639C>A	ENST00000462705.1	-	11	1888	c.1067G>T	c.(1066-1068)gGt>gTt	p.G356V	ZBTB20_ENST00000471418.1_Missense_Mutation_p.G356V|ZBTB20_ENST00000464560.1_Missense_Mutation_p.G356V|ZBTB20_ENST00000357258.3_Missense_Mutation_p.G356V|ZBTB20_ENST00000481632.1_Missense_Mutation_p.G356V|ZBTB20_ENST00000393785.2_Missense_Mutation_p.G356V|ZBTB20_ENST00000474710.1_Missense_Mutation_p.G429V	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	429					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		AGAGGAAGCACCTGTTTCTAG	0.607000													31	60					6.02846e-25	6.75918e-25	1	1	0
AVPR1A	0	broad.mit.edu	37	12	63543962	63543962	+	Missense_Mutation	SNP	A	A	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr12:63543962A>T	ENST00000299178.2	-	1	760	c.655T>A	c.(655-657)Tgg>Agg	p.W219R		NM_000706.4	NP_000697.1	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	219					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|prostate(2)|skin(1)	26			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	CCCGTCATCCAGGTCACGTAG	0.597000													4	142					0	0	1	0	0
SERPINB8	5271	broad.mit.edu	37	18	61652428	61652428	+	Missense_Mutation	SNP	G	G	C			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr18:61652428G>C	ENST00000397985.2	+	6	925	c.669G>C	c.(667-669)gaG>gaC	p.E223D	SERPINB8_ENST00000493661.1_3'UTR|SERPINB8_ENST00000397988.3_Missense_Mutation_p.E223D|SERPINB8_ENST00000353706.2_Missense_Mutation_p.E223D|SERPINB8_ENST00000542677.1_Missense_Mutation_p.E41D	NM_001276490.1	NP_001263419.1	P50452	SPB8_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 8	223					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	17		Esophageal squamous(42;0.129)				ATGTGGAAGAGGAGCTGAGCA	0.512000													11	27					0	0	1	0	0
ALG1L2	0	broad.mit.edu	37	3	129817105	129817105	+	RNA	SNP	A	A	G			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr3:129817105A>G	ENST00000507643.1	+	0	687							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										CTGATCCTGAAGGCAAGCTAA	0.527000													3	41					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13759951	13759951	+	Missense_Mutation	SNP	G	G	C			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr18:13759951G>C	ENST00000383314.2	+	12	1644	c.1404G>C	c.(1402-1404)ttG>ttC	p.L468F	RNMT_ENST00000262173.3_Missense_Mutation_p.L468F|RNMT_ENST00000535051.1_Missense_Mutation_p.L226F|RNMT_ENST00000592764.1_Intron|RNMT_ENST00000589866.1_Missense_Mutation_p.L468F|RNMT_ENST00000543302.2_Missense_Mutation_p.L468F			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	468					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						GTATTTACTTGGTGTTTGCCT	0.348000													17	17					0	0	1	0	0
RANBP6	26953	broad.mit.edu	37	9	6013360	6013360	+	Missense_Mutation	SNP	G	G	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr9:6013360G>A	ENST00000259569.5	-	1	2258	c.2248C>T	c.(2248-2250)Ctt>Ttt	p.L750F		NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	750					protein transport	cytoplasm|nucleus	binding	p.L750F(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATCTGTGCAAGATACTCTGGG	0.413000													11	86					0	0	1	0	0
FASTK	10922	broad.mit.edu	37	7	150776063	150776063	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr7:150776063C>T	ENST00000297532.6	-	3	628	c.551G>A	c.(550-552)cGa>cAa	p.R184Q	FASTK_ENST00000540185.1_Intron|FASTK_ENST00000482571.1_Missense_Mutation_p.R184Q|FASTK_ENST00000489884.1_5'UTR|FASTK_ENST00000353841.2_Missense_Mutation_p.R43Q	NM_006712.4	NP_006703.1	Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase	184					apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(4)|stomach(2)	6			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		GCGGAGCCTTCGCTCCTGTTC	0.607000													8	8					0	0	1	0	0
PCDHA4	0	broad.mit.edu	37	5	140188584	140188584	+	Silent	SNP	C	C	T	rs17844283		TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr5:140188584C>T	ENST00000530339.1	+	1	1812	c.1812C>T	c.(1810-1812)aaC>aaT	p.N604N	PCDHA4_ENST00000512229.2_Silent_p.N604N|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000356878.4_Silent_p.N604N|PCDHA1_ENST00000504120.2_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGCTACAACGCGTGGCTTT	0.682000													31	83					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111117853	111117853	+	Silent	SNP	C	C	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr13:111117853C>T	ENST00000360467.5	+	25	2184	c.1878C>T	c.(1876-1878)ccC>ccT	p.P626P		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	626	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			TGGGCCTTCCCGGCCTCAAAG	0.642000													4	35					0	0	1	0	0
IL10	3586	broad.mit.edu	37	1	206944256	206944256	+	Missense_Mutation	SNP	C	C	T			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr1:206944256C>T	ENST00000423557.1	-	3	432	c.374G>A	c.(373-375)cGc>cAc	p.R125H	IL10_ENST00000471071.1_5'UTR	NM_000572.2	NP_000563.1	P22301	IL10_HUMAN	interleukin 10	125					anti-apoptosis|B cell differentiation|B cell proliferation|cytoplasmic sequestering of NF-kappaB|inflammatory response|leukocyte chemotaxis|negative regulation of B cell proliferation|negative regulation of cytokine secretion involved in immune response|negative regulation of interferon-alpha biosynthetic process|negative regulation of interleukin-6 production|negative regulation of membrane protein ectodomain proteolysis|negative regulation of MHC class II biosynthetic process|negative regulation of T cell proliferation|positive regulation of B cell apoptosis|positive regulation of cytokine secretion|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|receptor biosynthetic process|regulation of isotype switching|response to glucocorticoid stimulus|type 2 immune response	extracellular space	cytokine activity|growth factor activity|interleukin-10 receptor binding			endometrium(1)|large_intestine(6)|lung(4)|prostate(1)	12	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			ACTTACACAGCGCCGTAGCCT	0.547000													22	33					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124297927	124297927	+	Missense_Mutation	SNP	G	G	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr12:124297927G>A	ENST00000409039.3	+	19	3032	c.3007G>A	c.(3007-3009)Gac>Aac	p.D1003N		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1003	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTGGAAATTGGACAAAGCTAT	0.388000													19	122					0	0	1	0	0
TMEM74	157753	broad.mit.edu	37	8	109796599	109796599	+	Silent	SNP	G	G	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr8:109796599G>A	ENST00000297459.3	-	2	907	c.729C>T	c.(727-729)ggC>ggT	p.G243G	TMEM74_ENST00000518838.1_Intron	NM_153015.1	NP_694560.1	Q96NL1	TMM74_HUMAN	transmembrane protein 74	243					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane		p.G243G(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			ACAGGATGACGCCCCCCAGCG	0.582000													15	59					0	0	1	0	0
MSH3	4437	broad.mit.edu	37	5	79950742	79950750	+	In_Frame_Del	DEL	CCCCCAGCT	CCCCCAGCT	-	rs3045983		TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr5:79950742_79950750delCCCCCAGCT	ENST00000265081.6	+	1	276_284	c.196_204delCCCCCAGCT	c.(196-204)del	p.PPA66del	DHFR_ENST00000439211.2_5'UTR	NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	66					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		gCCCCCAGCGCCCCCAGCTCCCGCCTTCC	0.732								Mismatch excision repair (MMR)					4	3	---	---	---	---					
GTF2IRD2P1	0	broad.mit.edu	37	7	72662348	72662349	+	RNA	INS	-	-	A			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr7:72662348_72662349insA	ENST00000425256.1	-	0	1007					NR_002164.1																						actctgtctccaaaaaaaaaaa	0.480													3	3	---	---	---	---					
SEMA3A	10371	broad.mit.edu	37	7	83590830	83590830	+	Frame_Shift_Del	DEL	C	C	-			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr7:83590830delC	ENST00000265362.3	-	17	2487	c.2173delG	c.(2173-2175)ttfs	p.V725fs	SEMA3A_ENST00000436949.1_Frame_Shift_Del_p.V725fs	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	725					axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CTTTTCCAAACTTGTTCACAG	0.453													7	141	---	---	---	---					
PI15	51050	broad.mit.edu	37	8	75761482	75761485	+	Frame_Shift_Del	DEL	TAAA	TAAA	-			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr8:75761482_75761485delTAAA	ENST00000260113.2	+	6	950_953	c.771_774delTAAA	c.(769-774)ttfs	p.FK257fs	PI15_ENST00000523773.1_Frame_Shift_Del_p.FK257fs|RP11-758M4.4_ENST00000522914.1_RNA|RP11-758M4.4_ENST00000518128.1_RNA|RP11-758M4.4_ENST00000523860.1_RNA	NM_015886.3	NP_056970.1	O43692	PI15_HUMAN	peptidase inhibitor 15	257						extracellular region	peptidase inhibitor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|skin(1)	30	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			TGTACTGGTTTAAATAAGTTTACC	0.358													38	41	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49440431	49440431	+	Frame_Shift_Del	DEL	G	G	-			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr12:49440431delG	ENST00000301067.7	-	15	4378	c.4379delC	c.(4378-4380)cafs	p.P1460fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGTGAGCAGTGGGGGGTCCAG	0.562													48	91	---	---	---	---					
C17orf104	284071	broad.mit.edu	37	17	42746783	42746783	+	Frame_Shift_Del	DEL	A	A	-			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr17:42746783delA	ENST00000409122.2	+	6	2497	c.2355delA	c.(2353-2355)ggfs	p.G785fs	C17orf104_ENST00000409464.1_Frame_Shift_Del_p.G619fs|C17orf104_ENST00000359945.3_Frame_Shift_Del_p.G785fs	NM_001145080.2	NP_001138552.2	A2RUB1	CQ104_HUMAN	chromosome 17 open reading frame 104	785										autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|pancreas(1)|skin(1)	24						ATTATCCTGGAAAAAAAGTAT	0.353													2	4	---	---	---	---					
CD37	0	broad.mit.edu	37	19	49842112	49842114	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr19:49842112_49842114delCAG	ENST00000535669.2	+	6	717_719	c.603_605delCAG	c.(601-606)ctc>ct	p.LS201del	CD37_ENST00000323906.4_In_Frame_Del_p.LS201del|CD37_ENST00000426897.2_In_Frame_Del_p.LS133del|CD37_ENST00000598095.1_In_Frame_Del_p.LS133del|CTC-301O7.4_ENST00000358234.4_lincRNA			P11049	CD37_HUMAN	CD37 molecule	201						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	11		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		TGCCCCAGCTCAGCAGGCTTGGA	0.621													22	55	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085940	11085942	+	RNA	DEL	CAC	CAC	-			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr21:11085940_11085942delCAC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccaccaccatcaccaccaccacc	0.532													2	4	---	---	---	---					
KRTAP10-1	386677	broad.mit.edu	37	21	45959946	45959946	+	Frame_Shift_Del	DEL	G	G	-			TCGA-VN-A88P-01A-11D-A34U-08	TCGA-VN-A88P-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cf4265c8-5f60-4f71-8ade-cb73044fa524	afbadcf2-d858-478b-adda-23f04631ad78	g.chr21:45959946delG	ENST00000400375.1	-	1	132	c.88delC	c.(88-90)acfs	p.H30fs	TSPEAR_ENST00000323084.4_Intron|TSPEAR_ENST00000397916.1_Intron	NM_198691.2	NP_941964.2	P60331	KR101_HUMAN	keratin associated protein 10-1	30	24 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|central_nervous_system(1)|endometrium(1)|lung(3)|prostate(4)|skin(1)	11						GCGCAGCAGTGGGGCTCACAG	0.701													58	57	---	---	---	---