Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM13C	220965	broad.mit.edu	37	10	61083780	61083780	+	Missense_Mutation	SNP	G	G	T			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr10:61083780G>T	ENST00000373867.3	-	5	627	c.162C>A	c.(160-162)ttC>ttA	p.F54L	FAM13C_ENST00000373868.2_Missense_Mutation_p.F137L|FAM13C_ENST00000442566.3_Missense_Mutation_p.F137L|FAM13C_ENST00000419214.2_Missense_Mutation_p.F137L|FAM13C_ENST00000510215.2_5'UTR|FAM13C_ENST00000277705.6_Missense_Mutation_p.F137L|FAM13C_ENST00000468840.2_Missense_Mutation_p.F54L|FAM13C_ENST00000422313.2_Missense_Mutation_p.F137L|FAM13C_ENST00000435852.2_Missense_Mutation_p.F137L	NM_001166698.1	NP_001160170.1	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	137										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CTTGGCACTTGAAGGCATTGT	0.488000													7	193					0.000157383	0.000169187	1	1	0
ZNF534	147658	broad.mit.edu	37	19	52942411	52942411	+	Silent	SNP	G	G	A	rs113700997		TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr19:52942411G>A	ENST00000332323.6	+	4	1798	c.1737G>A	c.(1735-1737)gcG>gcA	p.A579A	ZNF534_ENST00000301085.4_Intron|ZNF534_ENST00000432303.2_Intron|ZNF534_ENST00000433050.1_Silent_p.A566A	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	579					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.A579A(4)		central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						CACACCTTGCGCGACATAGGA	0.443000													3	18					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													3	40					0	0	1	0	0
AJ271736.10	0	broad.mit.edu	37	X	155255153	155255153	+	RNA	SNP	G	G	A			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chrX:155255153G>A	ENST00000285718.7	+	0	1458				WASH6P_ENST00000461007.1_RNA																							GACGGAACCAGCACTGTGTGG	0.637000													3	10					0	0	1	0	0
MMP12	4321	broad.mit.edu	37	11	102733793	102733793	+	RNA	SNP	C	C	G			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr11:102733793C>G	ENST00000532855.1	-	0	1546							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	ACTTATTAAGCTGAAGTGAAC	0.313000													4	52					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15655705	15655705	+	Missense_Mutation	SNP	C	C	T			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr10:15655705C>T	ENST00000378076.3	-	15	1860	c.1507G>A	c.(1507-1509)Gaa>Aaa	p.E503K		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	503					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						GTTTTATTTTCAAGATTGATA	0.453000													5	129					0	0	1	0	0
AKAP11	11215	broad.mit.edu	37	13	42875269	42875269	+	Missense_Mutation	SNP	C	C	A			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr13:42875269C>A	ENST00000025301.2	+	8	2562	c.2387C>A	c.(2386-2388)tCt>tAt	p.S796Y		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	796					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		CATATTTCATCTACTGCATGT	0.428000													7	86					0.00198382	0.00203105	1	1	0
AP2B1	163	broad.mit.edu	37	17	33977805	33977805	+	Missense_Mutation	SNP	G	G	A			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr17:33977805G>A	ENST00000262325.7	+	13	2346	c.1793G>A	c.(1792-1794)gGg>gAg	p.G598E	AP2B1_ENST00000545922.2_3'UTR|AP2B1_ENST00000312678.8_Missense_Mutation_p.G598E|AP2B1_ENST00000592545.1_Missense_Mutation_p.G560E|AP2B1_ENST00000589344.1_Missense_Mutation_p.G598E|AP2B1_ENST00000537622.2_Missense_Mutation_p.G598E|AP2B1_ENST00000538556.1_Missense_Mutation_p.G541E	NM_001282.2	NP_001273.1	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1 subunit	598	Pro-rich (stalk region).				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		ATTCATCATGGGAGGTAAGAA	0.418000													4	86					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23901870	23901870	+	Silent	SNP	G	G	A	rs45500700	byFrequency	TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr14:23901870G>A	ENST00000355349.3	-	5	642	c.480C>T	c.(478-480)aaC>aaT	p.N160N		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	160	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ACTGATAGGCGTTGTCGGAGA	0.612000													5	124					0	0	1	0	0
SMC1A	8243	broad.mit.edu	37	X	53436013	53436013	+	Missense_Mutation	SNP	G	G	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chrX:53436013G>C	ENST00000322213.4	-	9	1652	c.1525C>G	c.(1525-1527)Cgc>Ggc	p.R509G	SMC1A_ENST00000375340.6_Missense_Mutation_p.R275G	NM_006306.2	NP_006297.2	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	509	Flexible hinge.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(8)|ovary(5)|upper_aerodigestive_tract(2)	49						GGGTAAAGGCGCTTGATGCTT	0.562000													4	27					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123179076	123179076	+	Silent	SNP	T	T	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chrX:123179076T>C	ENST00000371160.1	+	8	815	c.525T>C	c.(523-525)ttT>ttC	p.F175F	STAG2_ENST00000354548.5_Silent_p.F106F|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000218089.9_Silent_p.F175F|STAG2_ENST00000371144.3_Silent_p.F175F|STAG2_ENST00000371145.3_Silent_p.F175F|STAG2_ENST00000371157.3_Silent_p.F175F			Q8N3U4	STAG2_HUMAN	stromal antigen 2	175					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						AATCCAGTTTTTGTGAATTCA	0.343000													18	157					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133053842	133053842	+	Nonsense_Mutation	SNP	G	G	A			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr8:133053842G>A	ENST00000262283.5	-	8	961	c.862C>T	c.(862-864)Cga>Tga	p.R288*	OC90_ENST00000603859.1_Nonsense_Mutation_p.R92*|OC90_ENST00000254627.3_Nonsense_Mutation_p.R92*|OC90_ENST00000443356.2_Nonsense_Mutation_p.R92*			Q02509	OC90_HUMAN	otoconin 90	92					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			TCAAAGTCTCGGGGGCAGAGA	0.532000													3	49					0	0	1	0	0
AP2B1	163	broad.mit.edu	37	17	33977804	33977804	+	Missense_Mutation	SNP	G	G	A			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr17:33977804G>A	ENST00000262325.7	+	13	2345	c.1792G>A	c.(1792-1794)Ggg>Agg	p.G598R	AP2B1_ENST00000545922.2_3'UTR|AP2B1_ENST00000312678.8_Missense_Mutation_p.G598R|AP2B1_ENST00000592545.1_Missense_Mutation_p.G560R|AP2B1_ENST00000589344.1_Missense_Mutation_p.G598R|AP2B1_ENST00000537622.2_Missense_Mutation_p.G598R|AP2B1_ENST00000538556.1_Missense_Mutation_p.G541R	NM_001282.2	NP_001273.1	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1 subunit	598	Pro-rich (stalk region).				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		AATTCATCATGGGAGGTAAGA	0.423000													5	86					0	0	1	0	0
MLH3	27030	broad.mit.edu	37	14	75514215	75514215	+	Missense_Mutation	SNP	G	G	A			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr14:75514215G>A	ENST00000355774.2	-	2	2359	c.2144C>T	c.(2143-2145)cCc>cTc	p.P715L	MLH3_ENST00000556740.1_Missense_Mutation_p.P715L|MLH3_ENST00000556257.1_Missense_Mutation_p.P715L|MLH3_ENST00000380968.2_5'UTR|MLH3_ENST00000238662.7_Missense_Mutation_p.P715L	NM_001040108.1	NP_001035197.1	Q9UHC1	MLH3_HUMAN	mutL homolog 3	715					mismatch repair|reciprocal meiotic recombination	chiasma|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|mismatched DNA binding|protein binding|satellite DNA binding			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	44				BRCA - Breast invasive adenocarcinoma(234;0.00688)		GGGGAAAGAGGGGGATGTATC	0.383000								Mismatch excision repair (MMR)					11	112					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8862290	8862290	+	Missense_Mutation	SNP	G	G	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr20:8862290G>C	ENST00000338037.6	+	32	3472	c.3445G>C	c.(3445-3447)Gaa>Caa	p.E1149Q	PLCB1_ENST00000378641.3_3'UTR	NM_015192.2	NP_056007.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	1149					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						GCTGGAGCAAGAATACCAAGA	0.453000													5	163					0	0	1	0	0
ANKRD26	22852	broad.mit.edu	37	10	27324083	27324083	+	Missense_Mutation	SNP	T	T	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr10:27324083T>C	ENST00000376087.4	-	24	3461	c.3296A>G	c.(3295-3297)aAg>aGg	p.K1099R	ANKRD26_ENST00000376070.3_Missense_Mutation_p.K656R|ANKRD26_ENST00000436985.2_Missense_Mutation_p.K1115R	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1098						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						GCTTAGGTCCTTTTGTACCCG	0.363000													4	181					0	0	1	0	0
ARSD	414	broad.mit.edu	37	X	2838677	2838677	+	Missense_Mutation	SNP	A	A	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chrX:2838677A>C	ENST00000381154.1	-	4	479	c.404T>G	c.(403-405)aTc>aGc	p.I135S	ARSD_ENST00000217890.6_5'UTR	NM_001669.3	NP_001660.2	P51689	ARSD_HUMAN	arylsulfatase D	135						lysosome	arylsulfatase activity|metal ion binding			large_intestine(3)|lung(3)	6		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CTGCTGCAAGATTCTTGCAAA	0.527000													4	23					0	0	1	0	0
MAMLD1	10046	broad.mit.edu	37	X	149639452	149639452	+	Missense_Mutation	SNP	C	C	G			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chrX:149639452C>G	ENST00000370401.2	+	4	1917	c.1607C>G	c.(1606-1608)cCa>cGa	p.P536R	MAMLD1_ENST00000426613.2_Missense_Mutation_p.P511R|MAMLD1_ENST00000432680.2_Missense_Mutation_p.P511R|MAMLD1_ENST00000262858.5_Missense_Mutation_p.P536R|MAMLD1_ENST00000455522.2_Missense_Mutation_p.P17R			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	536					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					GCCACGGAGCCATTTACTTTT	0.542000													13	32					0	0	1	0	0
HHAT	55733	broad.mit.edu	37	1	210577932	210577932	+	Missense_Mutation	SNP	C	C	T			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr1:210577932C>T	ENST00000367010.1	+	6	820	c.593C>T	c.(592-594)tCc>tTc	p.S198F	HHAT_ENST00000537898.1_Missense_Mutation_p.S133F|HHAT_ENST00000261458.3_Missense_Mutation_p.S198F|HHAT_ENST00000308852.6_Missense_Mutation_p.S153F|HHAT_ENST00000391905.3_Missense_Mutation_p.S198F|HHAT_ENST00000545781.1_Missense_Mutation_p.S135F|HHAT_ENST00000545154.1_Missense_Mutation_p.S199F|HHAT_ENST00000413764.2_Missense_Mutation_p.S198F|HHAT_ENST00000541565.1_Intron	NM_001170580.1	NP_001164051.1	Q5VTY9	HHAT_HUMAN	hedgehog acyltransferase	198					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane	GTP binding			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	27				OV - Ovarian serous cystadenocarcinoma(81;0.0136)|all cancers(67;0.161)|KIRC - Kidney renal clear cell carcinoma(1967;0.215)		GCATCGACCTCCTACTCCTTT	0.547000													16	92					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152359340	152359340	+	Silent	SNP	C	C	T			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr2:152359340C>T	ENST00000427231.2	-	167	24097	c.23895G>A	c.(23893-23895)gaG>gaA	p.E7965E	NEB_ENST00000509223.2_Intron|NEB_ENST00000409198.1_Silent_p.E6264E|NEB_ENST00000172853.10_Silent_p.E6264E|NEB_ENST00000397336.2_Silent_p.E2E|NEB_ENST00000603639.1_Silent_p.E7965E|NEB_ENST00000604864.1_Silent_p.E7965E|NEB_ENST00000397345.3_Silent_p.E7965E|NEB_ENST00000498015.2_Intron	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	6264					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTTTGACTCTCTCCATCTCTG	0.353000													3	31					0	0	1	0	0
UBE2L3	7332	broad.mit.edu	37	22	21947210	21947210	+	Missense_Mutation	SNP	G	G	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr22:21947210G>C	ENST00000342192.4	+	2	286	c.88G>C	c.(88-90)Gct>Cct	p.A30P	UBE2L3_ENST00000458578.2_Missense_Mutation_p.A88P|UBE2L3_ENST00000545681.1_Intron	NM_003347.3	NP_003338.1	P68036	UB2L3_HUMAN	ubiquitin-conjugating enzyme E2L 3	30					cell proliferation|cellular response to glucocorticoid stimulus|protein K11-linked ubiquitination|regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	ATP binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity		UBE2L3/KRAS(2)	large_intestine(4)	4	Colorectal(54;0.105)					GGTTGATGAAGCTAATTTATT	0.418000													3	43					0	0	1	0	0
GPNMB	10457	broad.mit.edu	37	7	23286530	23286530	+	Silent	SNP	A	A	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr7:23286530A>C	ENST00000258733.4	+	1	349	c.54A>C	c.(52-54)ccA>ccC	p.P18P	GPNMB_ENST00000381990.2_Silent_p.P18P|GPNMB_ENST00000539136.1_Silent_p.P18P|GPNMB_ENST00000453162.2_Silent_p.P18P|GPNMB_ENST00000409458.3_Silent_p.P18P			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	18					negative regulation of cell proliferation	melanosome				breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			CAAGATTGCCACTTGATGCCG	0.448000													4	90					0	0	1	0	0
OR2S2	56656	broad.mit.edu	37	9	35957215	35957215	+	Missense_Mutation	SNP	G	G	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr9:35957215G>C	ENST00000341959.2	-	1	936	c.881C>G	c.(880-882)cCc>cGc	p.P294R		NM_019897.2	NP_063950.2	Q9NQN1	OR2S1_HUMAN	olfactory receptor, family 2, subfamily S, member 2	294					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(8)|ovary(1)|skin(1)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(32;0.00613)|STAD - Stomach adenocarcinoma(86;0.194)			ATAGATGATGGGGTTGAGCAT	0.517000													4	115					0	0	1	0	0
HDHD1	8226	broad.mit.edu	37	X	7023871	7023871	+	Missense_Mutation	SNP	G	G	A			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chrX:7023871G>A	ENST00000381077.5	-	2	146	c.70C>T	c.(70-72)Cgg>Tgg	p.R24W	HDHD1_ENST00000540122.1_Missense_Mutation_p.R24W|HDHD1_ENST00000412827.2_Missense_Mutation_p.R24W|HDHD1_ENST00000498474.2_5'UTR|HDHD1_ENST00000424830.2_Missense_Mutation_p.R47W	NM_001178136.1|NM_012080.4	NP_001171607.1|NP_036212.3	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain containing 1	24					nucleotide metabolic process		metal ion binding|phosphatase activity			breast(2)|large_intestine(1)|lung(3)	6						GAATACAGCCGTTCAGTATCT	0.393000													3	10					0	0	1	0	0
CD1B	910	broad.mit.edu	37	1	158300734	158300734	+	Silent	SNP	G	G	A			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr1:158300734G>A	ENST00000368168.3	-	2	287	c.180C>T	c.(178-180)agC>agT	p.S60S		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	60					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					TGCCTGAGTCGCTATCCCAGC	0.463000													9	262					0	0	1	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94898588	94898588	+	Missense_Mutation	SNP	T	T	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr7:94898588T>C	ENST00000289495.5	+	12	2989	c.2773T>C	c.(2773-2775)Tct>Cct	p.S925P	PPP1R9A_ENST00000424654.1_Missense_Mutation_p.S943P|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.S965P|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.S943P|PPP1R9A_ENST00000340694.4_Intron|PPP1R9A_ENST00000433881.1_Intron	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	925	Interacts with TGN38 (By similarity).					cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			GAGAACGTCTTCTCCAGAATC	0.433000										HNSCC(28;0.073)			6	34					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15757912	15757912	+	Missense_Mutation	SNP	C	C	A			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr19:15757912C>A	ENST00000221307.7	+	4	442	c.394C>A	c.(394-396)Ctg>Atg	p.L132M	CYP4F3_ENST00000591058.1_Missense_Mutation_p.L132M|CYP4F3_ENST00000585846.1_Missense_Mutation_p.L132M|CYP4F3_ENST00000586182.1_Missense_Mutation_p.L132M	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	132					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						GAAGCCCTGGCTGGGTGAGTA	0.582000													5	114					3.59834e-05	4.0718e-05	1	1	0
ZFHX3	463	broad.mit.edu	37	16	72845836	72845836	+	Missense_Mutation	SNP	G	G	T			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr16:72845836G>T	ENST00000268489.5	-	6	4303	c.3631C>A	c.(3631-3633)Cca>Aca	p.P1211T	ZFHX3_ENST00000397992.5_Missense_Mutation_p.P297T	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1211					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				GCTGTTTTTGGTCGCTTCGAA	0.532000													8	134					5.18039e-06	6.02045e-06	1	1	0
GRM1	2911	broad.mit.edu	37	6	146720225	146720225	+	Missense_Mutation	SNP	C	C	T			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr6:146720225C>T	ENST00000392299.2	+	8	2520	c.2050C>T	c.(2050-2052)Cgc>Tgc	p.R684C	GRM1_ENST00000282753.1_Missense_Mutation_p.R684C|GRM1_ENST00000355289.4_Missense_Mutation_p.R684C|GRM1_ENST00000507907.1_Missense_Mutation_p.R684C|GRM1_ENST00000492807.2_Missense_Mutation_p.R684C|GRM1_ENST00000361719.2_Missense_Mutation_p.R684C			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	684					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.R684C(3)		NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TCGTATTGCACGCATCCTGGC	0.527000													18	138					0	0	1	0	0
DLL4	54567	broad.mit.edu	37	15	41227101	41227101	+	Missense_Mutation	SNP	G	G	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr15:41227101G>C	ENST00000249749.5	+	8	1302	c.1026G>C	c.(1024-1026)caG>caC	p.Q342H		NM_019074.3	NP_061947.1	Q9NR61	DLL4_HUMAN	delta-like 4 (Drosophila)	342	EGF-like 4.				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(3)|large_intestine(1)	4		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		TCCAGGACCAGGAGGATGGCT	0.607000													4	100					0	0	1	0	0
ZNF18	7566	broad.mit.edu	37	17	11881383	11881383	+	Missense_Mutation	SNP	T	T	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr17:11881383T>C	ENST00000322748.3	-	9	2145	c.1541A>G	c.(1540-1542)cAc>cGc	p.H514R	ZNF18_ENST00000580306.1_Missense_Mutation_p.H514R|ZNF18_ENST00000580613.1_3'UTR|ZNF18_ENST00000454073.3_Missense_Mutation_p.H513R	NM_144680.2	NP_653281.2	P17022	ZNF18_HUMAN	zinc finger protein 18	514					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	14				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		CTCTCCAGTGTGAACCCTCTG	0.423000													7	96					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990019	63990019	+	Silent	SNP	G	G	A			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr6:63990019G>A	ENST00000370657.4	-	4	1470	c.1437C>T	c.(1435-1437)acC>acT	p.T479T	LGSN_ENST00000370658.5_3'UTR			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	479					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	ATCGAATAAAGGTTTCTCCTA	0.368000													5	110					0	0	1	0	0
MATN2	4147	broad.mit.edu	37	8	99030231	99030231	+	Missense_Mutation	SNP	T	T	G			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr8:99030231T>G	ENST00000254898.5	+	12	1937	c.1706T>G	c.(1705-1707)gTc>gGc	p.V569G	MATN2_ENST00000522025.2_Missense_Mutation_p.V285G|MATN2_ENST00000524308.1_Missense_Mutation_p.V528G|MATN2_ENST00000521689.1_Missense_Mutation_p.V569G|MATN2_ENST00000520016.1_Missense_Mutation_p.V569G	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	569	EGF-like 9.					proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			GGGAAAGATGTCTGCCAAGCT	0.488000													9	251					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5210793	5210793	+	Missense_Mutation	SNP	G	G	C			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr19:5210793G>C	ENST00000372412.4	-	34	5494	c.5261C>G	c.(5260-5262)aCa>aGa	p.T1754R	PTPRS_ENST00000592099.1_Missense_Mutation_p.T1306R|PTPRS_ENST00000262963.6_Missense_Mutation_p.T1733R|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000588012.1_Missense_Mutation_p.T1715R|PTPRS_ENST00000587303.1_Missense_Mutation_p.T1753R|PTPRS_ENST00000357368.4_Missense_Mutation_p.T1753R|PTPRS_ENST00000348075.2_Missense_Mutation_p.T1715R|PTPRS_ENST00000353284.2_Missense_Mutation_p.T1306R			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1753	Tyrosine-protein phosphatase 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		CGGCCCCTGTGTCGCGATGTA	0.657000													3	33					0	0	1	0	0
STOX1	219736	broad.mit.edu	37	10	70645938	70645938	+	Missense_Mutation	SNP	A	A	G			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr10:70645938A>G	ENST00000298596.6	+	3	2469	c.2386A>G	c.(2386-2388)Aga>Gga	p.R796G	STOX1_ENST00000399169.4_Missense_Mutation_p.R796G|STOX1_ENST00000399165.4_Intron|STOX1_ENST00000421961.2_Missense_Mutation_p.R686G|STOX1_ENST00000399162.2_Intron	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	796						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						GGTGCTTAAAAGAAATGAATG	0.468000													4	68					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114270000	114270000	+	Silent	SNP	G	G	A			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr7:114270000G>A	ENST00000393500.3	+	11	1132	c.312G>A	c.(310-312)caG>caA	p.Q104Q	FOXP2_ENST00000393494.2_Silent_p.Q179Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000393498.2_Silent_p.Q159Q|FOXP2_ENST00000403559.4_Silent_p.Q196Q|FOXP2_ENST00000350908.4_Silent_p.Q179Q|FOXP2_ENST00000393489.3_Silent_p.Q87Q|FOXP2_ENST00000360232.4_Silent_p.Q179Q|FOXP2_ENST00000393491.3_Silent_p.Q87Q|FOXP2_ENST00000408937.3_Silent_p.Q204Q|FOXP2_ENST00000390668.3_Silent_p.Q203Q|FOXP2_ENST00000378237.3_Silent_p.Q179Q			O15409	FOXP2_HUMAN	forkhead box P2	179	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q204Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						agcaacaacagcagcagcagc	0.498000													5	58					0	0	1	0	0
CD2BP2	10421	broad.mit.edu	37	16	30365550	30365552	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr16:30365550_30365552delCAT	ENST00000305596.3	-	3	345_347	c.170_172delATG	c.(169-174)ggg>g	p.DG57del	CD2BP2_ENST00000569466.1_In_Frame_Del_p.DG57del	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	57					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						CTGGACCCCCCATCATCATCATC	0.532													7	343	---	---	---	---					
NANOS3	342977	broad.mit.edu	37	19	13988558	13988559	+	In_Frame_Ins	INS	-	-	GAG	rs148122339	by1000genomes	TCGA-VP-A87E-01A-31D-A34U-08	TCGA-VP-A87E-10A-01D-A34X-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	eae221e0-1a67-4302-a04a-10195507d23b	a73d17ac-6872-4b3d-a945-212f2a20d843	g.chr19:13988558_13988559insGAG	ENST00000397555.2	+	2	439_440	c.439_440insGAG	c.(439-441)agg>GAGagg	p.146_147insE	NANOS3_ENST00000591727.1_Intron|NANOS3_ENST00000591161.1_5'UTR|NANOS3_ENST00000339133.5_In_Frame_Ins_p.165_166insE	NM_001098622.2	NP_001092092.1	P60323	NANO3_HUMAN	nanos homolog 3 (Drosophila)	146					anti-apoptosis|germ cell development|multicellular organismal development|oogenesis|regulation of cell cycle|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|nucleus|stress granule	RNA binding|zinc ion binding	p.G171delG(1)		breast(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	7			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			AGGCCACCGCCGAGGAGGAGGA	0.644													4	4	---	---	---	---