Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RGPD3	653489	broad.mit.edu	37	2	107049631	107049631	+	Silent	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr2:107049631C>T	ENST00000409886.3	-	16	2403	c.2316G>A	c.(2314-2316)gcG>gcA	p.A772A	RGPD3_ENST00000304514.7_Silent_p.A772A	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	772					intracellular transport		binding	p.A772A(4)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TTTCTGAATCCGCATTTCGCA	0.373000													7	327					0	0	1	0	0
MED30	90390	broad.mit.edu	37	8	118533268	118533268	+	Silent	SNP	C	C	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr8:118533268C>A	ENST00000297347.3	+	1	317	c.153C>A	c.(151-153)atC>atA	p.I51I	MED30_ENST00000522839.1_Silent_p.I51I	NM_080651.2	NP_542382.1	Q96HR3	MED30_HUMAN	mediator complex subunit 30	51					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			kidney(1)|lung(3)|prostate(3)	7	all_cancers(13;3.41e-25)|Lung NSC(37;3.02e-05)|Ovarian(258;0.00163)		STAD - Stomach adenocarcinoma(47;0.0266)			CCATGGAGATCTTCCAGCTCC	0.657000													28	19					1.74807e-11	1.90141e-11	1	1	0
TXNDC2	0	broad.mit.edu	37	18	9887095	9887095	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr18:9887095G>A	ENST00000306084.6	+	2	818	c.619G>A	c.(619-621)Ggt>Agt	p.G207S	TXNDC2_ENST00000536353.2_Intron|TXNDC2_ENST00000357775.4_Missense_Mutation_p.G140S	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	207	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						GCCCAAAGAGGGTGACATCCC	0.567000													4	125					0	0	1	0	0
GLS2	27165	broad.mit.edu	37	12	56868873	56868873	+	Silent	SNP	T	T	C			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr12:56868873T>C	ENST00000311966.4	-	10	1229	c.951A>G	c.(949-951)acA>acG	p.T317T	GLS2_ENST00000476991.1_5'UTR	NM_013267.2	NP_037399.2	Q9UI32	GLSL_HUMAN	glutaminase 2 (liver, mitochondrial)	317					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TCCGATCCCCTGTTTCCTTCT	0.473000													32	98					0	0	1	0	0
PPP1R1A	5502	broad.mit.edu	37	12	54974737	54974737	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr12:54974737T>C	ENST00000547431.1	-	4	308	c.281A>G	c.(280-282)gAg>gGg	p.E94G	PPP1R1A_ENST00000257905.8_Silent_p.G167G			Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1A	95					glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			lung(2)	2						CCGAGTTGGCTCCCTTGGAAT	0.498000													71	114					0	0	1	0	0
LIPI	149998	broad.mit.edu	37	21	15561724	15561724	+	Nonsense_Mutation	SNP	G	G	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr21:15561724G>T	ENST00000344577.2	-	2	151	c.126C>A	c.(124-126)tgC>tgA	p.C42*	LIPI_ENST00000536861.1_Nonsense_Mutation_p.C21*	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	21					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		AGAATTCAAGGCATGGTCTTT	0.338000													16	50					4.96729e-08	5.21986e-08	1	1	0
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr3:195505836G>C	ENST00000463781.3	-	2	13074	c.12615C>G	c.(12613-12615)caC>caG	p.H4205Q	MUC4_ENST00000475231.1_Missense_Mutation_p.H4205Q|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	968					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.H4205Q(10)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597000													4	6					0	0	1	0	0
PCDHA10	0	broad.mit.edu	37	5	140235918	140235918	+	Silent	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr5:140235918C>T	ENST00000307360.5	+	1	285	c.285C>T	c.(283-285)tgC>tgT	p.C95C	PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Silent_p.C95C|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAGCTGTGCGGGCGGAGCG	0.557000													4	203					0	0	1	0	0
SLC6A6	6533	broad.mit.edu	37	3	14509388	14509388	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr3:14509388T>C	ENST00000454876.2	+	8	1224	c.895T>C	c.(895-897)Ttc>Ctc	p.F299L	SLC6A6_ENST00000360861.3_Missense_Mutation_p.F299L			P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 6	299					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)	28						GACTCAGATATTCTTCTCTTA	0.577000											OREG0015421	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	25					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56341013	56341013	+	Silent	SNP	A	A	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr6:56341013A>T	ENST00000370754.5	-	92	21704	c.21705T>A	c.(21703-21705)acT>acA	p.T7235T	DST_ENST00000312431.6_3'UTR|DST_ENST00000446842.2_Silent_p.T6731T|DST_ENST00000370769.4_Silent_p.T7057T|DST_ENST00000244364.6_Silent_p.T4643T|DST_ENST00000421834.2_Silent_p.T4969T|DST_ENST00000370788.2_Silent_p.T4860T|DST_ENST00000361203.3_Silent_p.T6946T			Q03001	DYST_HUMAN	dystonin	7055	EF-hand 2.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TATCCTTATCAGTAAGTGTAG	0.433000													12	21					0	0	1	0	0
EI24	9538	broad.mit.edu	37	11	125452260	125452260	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr11:125452260C>G	ENST00000278903.6	+	10	1046	c.804C>G	c.(802-804)atC>atG	p.I268M	STT3A-AS1_ENST00000530526.1_RNA|STT3A-AS1_ENST00000532714.1_RNA|EI24_ENST00000530985.1_3'UTR|EI24_ENST00000343678.4_Missense_Mutation_p.S231C	NM_004879.3	NP_004870.3	O14681	EI24_HUMAN	etoposide induced 2.4	268					apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				large_intestine(1)|lung(9)|ovary(1)	11	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		TTTTCTCTATCCTCTTTCCTT	0.353000													3	10					0	0	1	0	0
CDC20	991	broad.mit.edu	37	1	43825643	43825643	+	Missense_Mutation	SNP	A	A	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr1:43825643A>T	ENST00000372462.1	+	4	634	c.431A>T	c.(430-432)tAt>tTt	p.Y144F	CDC20_ENST00000478882.1_3'UTR|CDC20_ENST00000310955.6_Missense_Mutation_p.Y144F			Q12834	CDC20_HUMAN	cell division cycle 20	144					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	15	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GCCACAGGTTATCAGAACAGA	0.522000													5	158					0	0	1	0	0
ZMYND15	84225	broad.mit.edu	37	17	4648068	4648068	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr17:4648068T>C	ENST00000433935.1	+	11	1889	c.1832T>C	c.(1831-1833)gTt>gCt	p.V611A	ZMYND15_ENST00000573751.2_Missense_Mutation_p.V611A|ZMYND15_ENST00000269289.6_Missense_Mutation_p.V572A|ZMYND15_ENST00000592813.1_Missense_Mutation_p.V572A	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	572							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						CCTGACCTGGTTATTGGTAAA	0.602000													16	19					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049681	107049681	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr2:107049681T>C	ENST00000409886.3	-	16	2353	c.2266A>G	c.(2266-2268)Aac>Gac	p.N756D	RGPD3_ENST00000304514.7_Missense_Mutation_p.N756D	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	756					intracellular transport		binding	p.N756D(6)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TCACTATAGTTTTCGAGTTCC	0.373000													7	469					0	0	1	0	0
TXNDC2	0	broad.mit.edu	37	18	9887098	9887098	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr18:9887098G>A	ENST00000306084.6	+	2	821	c.622G>A	c.(622-624)Gac>Aac	p.D208N	TXNDC2_ENST00000536353.2_Intron|TXNDC2_ENST00000357775.4_Missense_Mutation_p.D141N	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	208	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						CAAAGAGGGTGACATCCCCAA	0.557000													4	121					0	0	1	0	0
AC004381.6	0	broad.mit.edu	37	16	20856421	20856421	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr16:20856421C>T	ENST00000261377.6	+	18	2191	c.1982C>T	c.(1981-1983)aCa>aTa	p.T661I	AC004381.6_ENST00000564274.1_Missense_Mutation_p.T661I|AC004381.6_ENST00000348433.6_Missense_Mutation_p.T630I|ERI2_ENST00000564349.1_Intron	NM_001199053.1|NM_030941.2	NP_001185982.1|NP_112203.2																					AACATTCTCACAGGCAAGGAC	0.532000													20	29					0	0	1	0	0
CSDC2	27254	broad.mit.edu	37	22	41970869	41970869	+	Missense_Mutation	SNP	G	G	C			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr22:41970869G>C	ENST00000306149.7	+	4	976	c.432G>C	c.(430-432)gaG>gaC	p.E144D		NM_014460.3	NP_055275.1	Q9Y534	CSDC2_HUMAN	cold shock domain containing C2, RNA binding	144					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|RNA binding			prostate(2)|upper_aerodigestive_tract(1)	3						CTCCCCACGAGACGTGGTCTG	0.652000													5	10					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77651486	77651486	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr3:77651486G>A	ENST00000461745.1	+	20	3880	c.2980G>A	c.(2980-2982)Gct>Act	p.A994T	ROBO2_ENST00000332191.8_Missense_Mutation_p.A994T|ROBO2_ENST00000487694.3_Missense_Mutation_p.A1010T	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	994					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		AATAACACAGGCTACCCCATA	0.438000													21	25					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7049115	7049115	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr18:7049115G>A	ENST00000389658.3	-	5	823	c.730C>T	c.(730-732)Cgg>Tgg	p.R244W		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	244	Laminin N-terminal.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTAGGTTCCCGGTGGCTAAGG	0.428000													30	57					0	0	1	0	0
IGF1R	3480	broad.mit.edu	37	15	99251295	99251295	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr15:99251295A>G	ENST00000268035.6	+	2	1210	c.599A>G	c.(598-600)gAg>gGg	p.E200G	IGF1R_ENST00000558762.1_Missense_Mutation_p.E200G	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	200					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	ATCAACAATGAGTACAACTAC	0.517000													25	42					0	0	1	0	0
ZIM3	0	broad.mit.edu	37	19	57646680	57646680	+	Missense_Mutation	SNP	T	T	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr19:57646680T>A	ENST00000269834.1	-	5	1410	c.1025A>T	c.(1024-1026)aAg>aTg	p.K342M		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGAAAAGGCCTTCTCACATAT	0.408000													59	88					0	0	1	0	0
ALG1L2	0	broad.mit.edu	37	3	129817063	129817063	+	RNA	SNP	C	C	T	rs142072122	by1000genomes	TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr3:129817063C>T	ENST00000507643.1	+	0	647							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										CTCTGCTCTTCAGTATTTTGC	0.552000													3	34					0	0	1	0	0
OXCT1	5019	broad.mit.edu	37	5	41807484	41807484	+	Silent	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr5:41807484C>T	ENST00000196371.5	-	8	949	c.789G>A	c.(787-789)caG>caA	p.Q263Q	OXCT1_ENST00000509987.1_Silent_p.Q77Q	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	263					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	GTACATAAATCTGAGGAATAT	0.348000													27	98					0	0	1	0	0
CHAT	1103	broad.mit.edu	37	10	50870746	50870746	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr10:50870746G>A	ENST00000395562.2	+	15	2118	c.1649G>A	c.(1648-1650)cGg>cAg	p.R550Q	CHAT_ENST00000337653.2_Missense_Mutation_p.R632Q|CHAT_ENST00000395559.2_Missense_Mutation_p.R514Q|CHAT_ENST00000339797.1_Missense_Mutation_p.R514Q|CHAT_ENST00000351556.3_Missense_Mutation_p.R514Q|CHAT_ENST00000455728.2_Missense_Mutation_p.R514Q	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	632					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	GAGCTGGCCCGGGCCATGTGC	0.587000													41	63					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	39019295	39019295	+	Missense_Mutation	SNP	A	A	G			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr19:39019295A>G	ENST00000355481.4	+	74	11110	c.10979A>G	c.(10978-10980)gAa>gGa	p.E3660G	RYR1_ENST00000360985.3_Missense_Mutation_p.E3665G|RYR1_ENST00000359596.3_Missense_Mutation_p.E3665G	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3665					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ATCCTGACTGAAGACCACAGT	0.627000													25	41					0	0	1	0	0
CCDC62	84660	broad.mit.edu	37	12	123286202	123286202	+	Silent	SNP	C	C	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr12:123286202C>A	ENST00000253079.6	+	9	1853	c.1509C>A	c.(1507-1509)gcC>gcA	p.A503A	CCDC62_ENST00000537566.1_Silent_p.A264A|CCDC62_ENST00000392440.2_Silent_p.A264A|CCDC62_ENST00000392441.4_Silent_p.A503A	NM_201435.4	NP_958843.2	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62	503						cytoplasm|nucleus				breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		AAAATGAAGCCTGTCTGGGCG	0.478000													3	50					1	1	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								4	46					0	0	1	0	0
MARK4	57787	broad.mit.edu	37	19	45805762	45805762	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr19:45805762C>T	ENST00000262891.4	+	17	2384	c.2053C>T	c.(2053-2055)Cgc>Tgc	p.R685C	MARK4_ENST00000300843.4_3'UTR	NM_001199867.1	NP_001186796.1	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	685					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AGCAGCCGCCCGCTGCCGCTG	0.731000													15	28					0	0	1	0	0
OXCT1	5019	broad.mit.edu	37	5	41807440	41807440	+	Missense_Mutation	SNP	C	C	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr5:41807440C>A	ENST00000196371.5	-	8	993	c.833G>T	c.(832-834)aGa>aTa	p.R278I	OXCT1_ENST00000509987.1_Missense_Mutation_p.R92I	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	278					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	TACCTCAATTCTTTTCTCATA	0.403000													13	61					3.27435e-08	3.50017e-08	1	1	0
RFC3	5983	broad.mit.edu	37	13	34399991	34399991	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr13:34399991A>C	ENST00000380071.3	+	4	489	c.359A>C	c.(358-360)cAa>cCa	p.Q120P	RFC3_ENST00000434425.1_Missense_Mutation_p.Q120P	NM_002915.3	NP_002906.1	P40938	RFC3_HUMAN	replication factor C (activator 1) 3, 38kDa	120					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			lung(2)|skin(1)	3		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		CAATCACAACAACTTGAAACA	0.358000													12	34					0	0	1	0	0
ZNF679	168417	broad.mit.edu	37	7	63721245	63721245	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr7:63721245G>A	ENST00000421025.1	+	4	469	c.200G>A	c.(199-201)tGt>tAt	p.C67Y	ZNF679_ENST00000255746.4_Missense_Mutation_p.C67Y	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	67	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						TTGATCACCTGTCTGGAGCAA	0.363000													22	24					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35222776	35222776	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr14:35222776C>T	ENST00000360310.1	-	27	5176	c.4609G>A	c.(4609-4611)Gtc>Atc	p.V1537I	BAZ1A_ENST00000358716.4_Missense_Mutation_p.V1505I|BAZ1A_ENST00000382422.2_Missense_Mutation_p.V1537I	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	1537					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding	p.V1537I(1)		breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CTGGGTGTGACGTGGAGTCCA	0.418000													23	38					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22804358	22804358	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr18:22804358G>A	ENST00000361524.3	-	4	3672	c.3524C>T	c.(3523-3525)aCg>aTg	p.T1175M	ZNF521_ENST00000538137.2_Missense_Mutation_p.T1175M|ZNF521_ENST00000584787.1_Missense_Mutation_p.T955M	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	1175					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding	p.T1175M(1)		NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TACTTGGGGCGTTTTCAACTG	0.483000			T	PAX5	ALL								33	54					0	0	1	0	0
FNTB	2342	broad.mit.edu	37	14	65471020	65471020	+	Missense_Mutation	SNP	C	C	G			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr14:65471020C>G	ENST00000246166.2	+	2	432	c.198C>G	c.(196-198)caC>caG	p.H66Q	CHURC1-FNTB_ENST00000542227.1_Missense_Mutation_p.H20Q|FNTB_ENST00000555742.1_3'UTR|CHURC1-FNTB_ENST00000447296.2_Missense_Mutation_p.H100Q	NM_002028.3	NP_002019.1			farnesyltransferase, CAAX box, beta											breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14				all cancers(60;0.00115)|OV - Ovarian serous cystadenocarcinoma(108;0.00412)|BRCA - Breast invasive adenocarcinoma(234;0.011)		AGTTCAACCACCTTGTACCAA	0.453000													40	86					0	0	1	0	0
GRK7	131890	broad.mit.edu	37	3	141497196	141497196	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr3:141497196G>A	ENST00000264952.2	+	1	207	c.70G>A	c.(70-72)Gac>Aac	p.D24N		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	24					visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						GAAGCCCTCGGACTGCGACAG	0.692000													20	37					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702556	27702556	+	Silent	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr10:27702556G>A	ENST00000438700.3	-	1	741	c.624C>T	c.(622-624)ttC>ttT	p.F208F		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	208					spermatid development	integral to membrane	hedgehog receptor activity	p.F208F(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GAAGCGAGACGAAATTGGCTT	0.632000													16	36					0	0	1	0	0
OXCT1	5019	broad.mit.edu	37	5	41807525	41807525	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr5:41807525C>T	ENST00000196371.5	-	8	908	c.748G>A	c.(748-750)Gat>Aat	p.D250N	OXCT1_ENST00000509987.1_Missense_Mutation_p.D64N	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	250					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	GCTCCAATATCCACAATTTCT	0.303000													27	83					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93108738	93108738	+	Nonsense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr7:93108738G>A	ENST00000359558.2	-	5	486	c.187C>T	c.(187-189)Cga>Tga	p.R63*	CALCR_ENST00000360249.4_Nonsense_Mutation_p.R45*|CALCR_ENST00000394441.1_Nonsense_Mutation_p.R45*|CALCR_ENST00000426151.1_Nonsense_Mutation_p.R45*|CALCR_ENST00000421592.1_Nonsense_Mutation_p.R45*	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	45					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding	p.R45*(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	ATCTTCTTTCGTCCTACGACG	0.398000													52	73					0	0	1	0	0
TRAV26-2	0	broad.mit.edu	37	14	22670501	22670501	+	RNA	SNP	G	G	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr14:22670501G>T	ENST00000390460.1	+	0	25																											AAGCATTACTGTACTCCTATC	0.448000													6	41					0.0293803	0.0303597	1	1	0
ZCCHC8	55596	broad.mit.edu	37	12	122958560	122958560	+	Silent	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr12:122958560G>A	ENST00000543897.1	-	12	3249	c.894C>T	c.(892-894)agC>agT	p.S298S	ZCCHC8_ENST00000538116.1_Silent_p.S147S|ZCCHC8_ENST00000536306.1_Silent_p.S298S|ZCCHC8_ENST00000336229.4_Silent_p.S536S			Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	536						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		CGCTGTTTACGCTCTCGGCCT	0.552000													62	100					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900492	51900492	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr17:51900492C>T	ENST00000268919.4	+	1	254	c.98C>T	c.(97-99)gCg>gTg	p.A33V		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	33					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						ATCTACGTGGCGATCCAGCGC	0.552000													11	13					0	0	1	0	0
ADCY7	113	broad.mit.edu	37	16	50341044	50341044	+	Silent	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr16:50341044C>T	ENST00000394697.2	+	15	2176	c.1836C>T	c.(1834-1836)gtC>gtT	p.V612V	ADCY7_ENST00000566433.2_Silent_p.V612V|ADCY7_ENST00000537579.1_3'UTR|ADCY7_ENST00000538642.1_Silent_p.V612V|ADCY7_ENST00000254235.3_Silent_p.V612V			P51828	ADCY7_HUMAN	adenylate cyclase 7	612					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	TCGTCCATGTCCTGCTCATGC	0.647000													3	12					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23912044	23912044	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr13:23912044C>T	ENST00000382298.3	-	10	6559	c.5971G>A	c.(5971-5973)Gta>Ata	p.V1991I	SACS_ENST00000402364.1_Missense_Mutation_p.V1241I|SACS_ENST00000382292.3_Missense_Mutation_p.V1991I	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1991					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AGAAATCTTACGTTCTTCATG	0.368000													24	53					0	0	1	0	0
CUL3	8452	broad.mit.edu	37	2	225371708	225371708	+	Missense_Mutation	SNP	A	A	C			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr2:225371708A>C	ENST00000264414.4	-	7	1234	c.896T>G	c.(895-897)aTg>aGg	p.M299R	CUL3_ENST00000344951.4_Missense_Mutation_p.M233R|CUL3_ENST00000409096.1_Missense_Mutation_p.M275R|CUL3_ENST00000409777.1_Missense_Mutation_p.M275R	NM_003590.4	NP_003581.1	Q13618	CUL3_HUMAN	cullin 3	299					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding	p.M299R(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TAACTTGTACATGCAACCAAG	0.358000													14	23					0	0	1	0	0
ZNF709	163051	broad.mit.edu	37	19	12575380	12575380	+	Silent	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr19:12575380C>T	ENST00000397732.3	-	4	1527	c.1356G>A	c.(1354-1356)caG>caA	p.Q452Q	ZNF709_ENST00000428311.1_Silent_p.Q452Q|CTD-3105H18.18_ENST00000598753.1_Intron	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(3)|upper_aerodigestive_tract(3)	6						CTTTACCACACTGTTTACATT	0.403000													4	197					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25958882	25958882	+	Silent	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr15:25958882G>A	ENST00000356865.6	-	10	2394	c.2283C>T	c.(2281-2283)atC>atT	p.I761I		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	761					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		TGTAGACGTTGATCTCATCGG	0.622000													11	24					0	0	1	0	0
ALG1L2	0	broad.mit.edu	37	3	129817105	129817105	+	RNA	SNP	A	A	G			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr3:129817105A>G	ENST00000507643.1	+	0	687							C9J202	AG1L2_HUMAN							biosynthetic process		transferase activity, transferring glycosyl groups										CTGATCCTGAAGGCAAGCTAA	0.527000													5	37					0	0	1	0	0
NCSTN	23385	broad.mit.edu	37	1	160314581	160314581	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr1:160314581G>A	ENST00000368063.1	+	3	375	c.95G>A	c.(94-96)cGc>cAc	p.R32H	NCSTN_ENST00000392212.4_Missense_Mutation_p.R32H|NCSTN_ENST00000294785.5_Missense_Mutation_p.R52H|NCSTN_ENST00000535857.1_Missense_Mutation_p.R52H			Q92542	NICA_HUMAN	nicastrin	52					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(2)	34	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCCTGTGTTCGCCTGCTCAAC	0.423000													34	17					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103234815	103234815	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr7:103234815C>T	ENST00000428762.1	-	26	3823	c.3664G>A	c.(3664-3666)Gag>Aag	p.E1222K	RELN_ENST00000343529.5_Missense_Mutation_p.E1222K|RELN_ENST00000424685.2_Missense_Mutation_p.E1222K	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1222					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCTGCTTCTCGGACAGAATG	0.488000													104	137					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10897283	10897283	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr19:10897283G>A	ENST00000314646.5	+	7	1057	c.893G>A	c.(892-894)aGc>aAc	p.S298N	DNM2_ENST00000359692.6_Missense_Mutation_p.S298N|DNM2_ENST00000389253.4_Missense_Mutation_p.S298N|DNM2_ENST00000408974.4_Missense_Mutation_p.S298N|DNM2_ENST00000585892.1_Missense_Mutation_p.S298N|DNM2_ENST00000355667.6_Missense_Mutation_p.S298N			P50570	DYN2_HUMAN	dynamin 2	298					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			GCCCTACGTAGCAAACTACAG	0.597000			"""F, N, Splice, Mis, O"""		ETP ALL								12	17					0	0	1	0	0
PROM1	8842	broad.mit.edu	37	4	16026833	16026833	+	Silent	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr4:16026833G>A	ENST00000505450.1	-	5	1197	c.585C>T	c.(583-585)ctC>ctT	p.L195L	PROM1_ENST00000508167.1_Silent_p.L195L|PROM1_ENST00000539194.1_Silent_p.L204L|PROM1_ENST00000543373.1_Silent_p.L195L|PROM1_ENST00000540805.1_Silent_p.L204L|PROM1_ENST00000502943.1_5'UTR|PROM1_ENST00000510224.1_Silent_p.L204L|PROM1_ENST00000447510.2_Silent_p.L204L	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	204					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						TTTCATTCAAGAGAGTTCGCA	0.403000													45	89					0	0	1	0	0
AMZ2P1	0	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													4	119					0	0	1	0	0
SDHAP1	0	broad.mit.edu	37	3	195690149	195690149	+	RNA	SNP	A	A	G			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr3:195690149A>G	ENST00000427841.1	-	0	2325					NR_003264.2																						TGACACATGCATGAGCTATTA	0.498000													3	7					0	0	1	0	0
ZNF507	22847	broad.mit.edu	37	19	32851518	32851518	+	Missense_Mutation	SNP	C	C	T			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr19:32851518C>T	ENST00000311921.3	+	4	2546	c.2354C>T	c.(2353-2355)cCg>cTg	p.P785L	ZNF507_ENST00000544431.1_Missense_Mutation_p.P785L|ZNF507_ENST00000355898.5_Missense_Mutation_p.P785L	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	785					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					TCTGATAAGCCGTACAGGTAA	0.289000													13	25					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71346978	71346978	+	Missense_Mutation	SNP	T	T	C			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr4:71346978T>C	ENST00000413702.1	+	4	805	c.517T>C	c.(517-519)Tct>Cct	p.S173P	MUC7_ENST00000514512.1_3'UTR|MUC7_ENST00000304887.5_Missense_Mutation_p.S173P|MUC7_ENST00000456088.1_Missense_Mutation_p.S173P	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	173	Thr-rich.					extracellular region	protein binding	p.S173P(3)		central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.522000													4	89					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10624677	10624677	+	Missense_Mutation	SNP	G	G	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr11:10624677G>A	ENST00000547195.1	-	13	2092	c.1592C>T	c.(1591-1593)gCc>gTc	p.A531V	MRVI1_ENST00000558540.1_Missense_Mutation_p.A307V|MRVI1_ENST00000552103.1_Missense_Mutation_p.A531V|MRVI1_ENST00000423302.2_Missense_Mutation_p.A622V|MRVI1_ENST00000421747.1_Missense_Mutation_p.A613V|MRVI1_ENST00000424001.1_Missense_Mutation_p.A307V|MRVI1_ENST00000534266.2_Missense_Mutation_p.A307V|MRVI1_ENST00000545852.1_Missense_Mutation_p.A307V|MRVI1_ENST00000541483.1_Missense_Mutation_p.A416V|MRVI1_ENST00000436272.1_Missense_Mutation_p.A595V|MRVI1_ENST00000531107.1_Missense_Mutation_p.A614V|MRVI1_ENST00000527509.2_Missense_Mutation_p.A531V|LYVE1_ENST00000531706.1_Intron	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	595	Interaction with ITPR1 (By similarity).				platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		CTGGCGGACGGCGCCTACCAC	0.612000													7	3					0	0	1	0	0
PCDHB4	0	broad.mit.edu	37	5	140502486	140502487	+	Frame_Shift_Ins	INS	-	-	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr5:140502486_140502487insA	ENST00000194152.1	+	1	906_907	c.906_907insA	c.(904-909)ttaaaafs	p.LK302fs		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		302	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding	p.K305fs*12(1)		autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATACTGTTGAAAAAAAAATT	0.366													7	125	---	---	---	---					
HERC2P2	0	broad.mit.edu	37	15	23299146	23299147	+	RNA	INS	-	-	A			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr15:23299146_23299147insA	ENST00000560464.1	-	0	4510																											TACATTCAAAGAAAAAAAAAAA	0.317													3	5	---	---	---	---					
SUZ12P	0	broad.mit.edu	37	17	29061756	29061759	+	RNA	DEL	ACTA	ACTA	-			TCGA-XK-AAJP-01A-11D-A41K-08	TCGA-XK-AAJP-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	64628bbc-a289-40e4-8bbc-ed53b7676771	50308439-7f7d-4b92-8264-c59f4afcedb9	g.chr17:29061756_29061759delACTA	ENST00000582557.1	+	0	676_679																											TACTGTGCATACTAACTTTCTTGA	0.304													2	4	---	---	---	---