Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CECR2	27443	broad.mit.edu	37	22	18029034	18029034	+	Silent	SNP	C	C	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr22:18029034C>A	ENST00000262608.8	+	16	3994	c.3994C>A	c.(3994-3996)Cgg>Agg	p.R1332R	CECR2_ENST00000400585.2_Silent_p.R1189R|CECR2_ENST00000400573.4_Silent_p.R1331R	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	1373					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		TACCCCTCAGCGGCCGGCCAG	0.622000													3	57					1	1	1	1	0
RFC5	5985	broad.mit.edu	37	12	118463581	118463581	+	Missense_Mutation	SNP	C	C	G			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr12:118463581C>G	ENST00000392542.2	+	8	1081	c.548C>G	c.(547-549)gCa>gGa	p.A183G	RFC5_ENST00000454402.2_Missense_Mutation_p.A204G|RFC5_ENST00000229043.3_Missense_Mutation_p.A119G	NM_181578.3	NP_853556.2	P40937	RFC5_HUMAN	replication factor C (activator 1) 5, 36.5kDa	204					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGAATGAAAGCACTAGTCACT	0.403000													32	35					0	0	1	0	0
ONECUT1	3175	broad.mit.edu	37	15	53080999	53080999	+	Silent	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr15:53080999G>A	ENST00000305901.5	-	1	1210	c.1083C>T	c.(1081-1083)cgC>cgT	p.R361R	ONECUT1_ENST00000561401.2_Intron	NM_004498.2	NP_004489.1	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	361					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	17				all cancers(107;0.0708)		GCGCGGACATGCGCTGGAACT	0.637000													27	18					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14875289	14875289	+	Missense_Mutation	SNP	T	T	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr19:14875289T>A	ENST00000315576.3	-	11	1491	c.1040A>T	c.(1039-1041)aAc>aTc	p.N347I	EMR2_ENST00000594294.1_Missense_Mutation_p.N298I|EMR2_ENST00000594076.1_Missense_Mutation_p.N254I|EMR2_ENST00000392964.3_Missense_Mutation_p.N86I|EMR2_ENST00000392965.3_Missense_Mutation_p.N347I|EMR2_ENST00000353005.1_Missense_Mutation_p.N205I|EMR2_ENST00000601345.1_Missense_Mutation_p.N347I|EMR2_ENST00000392967.2_Missense_Mutation_p.N347I|EMR2_ENST00000346057.1_Missense_Mutation_p.N298I|EMR2_ENST00000595839.1_Missense_Mutation_p.N205I|EMR2_ENST00000353876.1_Missense_Mutation_p.N254I|EMR2_ENST00000596991.2_Missense_Mutation_p.N347I	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	347					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						ATTGGAAAGGTTCTTGCTCAG	0.587000													13	12					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161816	90161816	+	RNA	SNP	C	C	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr16:90161816C>T	ENST00000564451.1	+	0	1169				TUBB8P7_ENST00000567960.1_RNA																							AGCCCTACAACGCCACCCTCT	0.488000													3	31					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29638247	29638247	+	Silent	SNP	C	C	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr1:29638247C>T	ENST00000373779.3	+	21	3177	c.3048C>T	c.(3046-3048)gtC>gtT	p.V1016V	PTPRU_ENST00000460170.2_Silent_p.V1022V|PTPRU_ENST00000415600.2_3'UTR|PTPRU_ENST00000345512.3_Silent_p.V1026V|PTPRU_ENST00000356870.3_Silent_p.V1022V|PTPRU_ENST00000323874.8_Silent_p.V1022V|PTPRU_ENST00000428026.2_Silent_p.V1013V	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1026	Tyrosine-protein phosphatase 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CTGAGTATGTCGTGCGCACTT	0.602000													46	84					0	0	1	0	0
FOXA1	3169	broad.mit.edu	37	14	38061208	38061208	+	Missense_Mutation	SNP	G	G	C			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr14:38061208G>C	ENST00000250448.2	-	2	842	c.781C>G	c.(781-783)Cgc>Ggc	p.R261G	FOXA1_ENST00000540786.1_Missense_Mutation_p.R228G|FOXA1_ENST00000545425.2_5'UTR	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	261					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TTCTGGCGGCGCAAGTAGCAG	0.716000													13	9					0	0	1	0	0
ATF2	1386	broad.mit.edu	37	2	175962238	175962238	+	Missense_Mutation	SNP	C	C	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr2:175962238C>A	ENST00000264110.2	-	11	1210	c.912G>T	c.(910-912)agG>agT	p.R304S	ATF2_ENST00000409635.1_Missense_Mutation_p.R246S|ATF2_ENST00000538946.1_Missense_Mutation_p.R286S|ATF2_ENST00000409499.1_Intron|ATF2_ENST00000392543.2_Intron|ATF2_ENST00000345739.5_Missense_Mutation_p.R246S|ATF2_ENST00000426833.3_Missense_Mutation_p.R286S|ATF2_ENST00000409437.1_Missense_Mutation_p.R188S|ATF2_ENST00000392544.1_Missense_Mutation_p.R304S|ATF2_ENST00000487334.2_3'UTR	NM_001256090.1|NM_001256091.1|NM_001880.3	NP_001243019.1|NP_001243020.1|NP_001871.2	P15336	ATF2_HUMAN	activating transcription factor 2	304					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.125)			CTGACTGAGTCCTAACCAATC	0.453000													44	52					2.77807e-22	3.09257e-22	1	1	0
SQRDL	58472	broad.mit.edu	37	15	45968418	45968418	+	Silent	SNP	C	C	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr15:45968418C>T	ENST00000260324.7	+	6	1160	c.774C>T	c.(772-774)aaC>aaT	p.N258N	SQRDL_ENST00000568606.1_Silent_p.N258N|RP11-96O20.4_ENST00000564080.1_Silent_p.N258N	NM_021199.2	NP_067022.1	Q9Y6N5	SQRD_HUMAN	sulfide quinone reductase-like (yeast)	258							oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	11		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		TCACTGTTAACTACAAGAAAA	0.458000													49	65					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182339937	182339937	+	Missense_Mutation	SNP	C	C	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr2:182339937C>A	ENST00000397033.2	+	4	908	c.478C>A	c.(478-480)Ctc>Atc	p.L160I	ITGA4_ENST00000478440.1_Intron|ITGA4_ENST00000339307.4_Missense_Mutation_p.L160I	NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	160					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TGAAAATAAGCTCCCCACTGG	0.383000													41	52					6.1244e-12	6.4525e-12	1	1	0
SLC34A2	10568	broad.mit.edu	37	4	25673235	25673235	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr4:25673235G>A	ENST00000382051.3	+	9	990	c.940G>A	c.(940-942)Gtc>Atc	p.V314I	SLC34A2_ENST00000504570.1_Missense_Mutation_p.V313I|SLC34A2_ENST00000503434.1_Missense_Mutation_p.V313I	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	314					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				CCAGATTAACGTCACTGTTCC	0.522000			T	ROS1	NSCLC								79	94					0	0	1	0	0
NLK	51701	broad.mit.edu	37	17	26488195	26488195	+	Silent	SNP	C	C	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr17:26488195C>T	ENST00000407008.3	+	4	1372	c.654C>T	c.(652-654)gtC>gtT	p.V218V		NM_016231.4	NP_057315.3	Q9UBE8	NLK_HUMAN	nemo-like kinase	218	Protein kinase.				intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(1)	14	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GATATGTTGTCACAGAATTGA	0.393000													10	34					0	0	1	0	0
THBS3	7059	broad.mit.edu	37	1	155173034	155173034	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr1:155173034G>A	ENST00000368378.3	-	6	756	c.736C>T	c.(736-738)Cgg>Tgg	p.R246W	RP11-263K19.4_ENST00000430312.1_RNA|THBS3_ENST00000487250.1_5'UTR|RP11-263K19.4_ENST00000453136.1_RNA|THBS3_ENST00000457183.2_Missense_Mutation_p.R126W|RP11-263K19.4_ENST00000422665.1_RNA|THBS3_ENST00000428962.2_Intron|THBS3_ENST00000541990.1_5'UTR	NM_001252607.1|NM_007112.4	NP_001239536.1|NP_009043.1	P49746	TSP3_HUMAN	thrombospondin 3	246					cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(6)|endometrium(4)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(3)	48	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			ATATCATCCCGCAGCTCCACC	0.602000													10	20					0	0	1	0	0
SLC35F4	341880	broad.mit.edu	37	14	58030926	58030926	+	Missense_Mutation	SNP	T	T	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr14:58030926T>A	ENST00000556826.1	-	8	1621	c.1385A>T	c.(1384-1386)gAt>gTt	p.D462V	SLC35F4_ENST00000339762.6_Missense_Mutation_p.D498V|SLC35F4_ENST00000554729.1_Missense_Mutation_p.D339V	NM_001206920.1	NP_001193849.1			solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						ATCAGTCACATCATCCACATG	0.498000													6	8					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108218045	108218045	+	Missense_Mutation	SNP	A	A	G			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr11:108218045A>G	ENST00000278616.4	+	59	9009	c.8624A>G	c.(8623-8625)aAt>aGt	p.N2875S	C11orf65_ENST00000525729.1_Intron|ATM_ENST00000452508.2_Missense_Mutation_p.N2875S|C11orf65_ENST00000526725.1_Intron|ATM_ENST00000525178.1_3'UTR	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2875	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.N2875T(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CATGTACAGAATATCTTGATA	0.303000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			61	5					0	0	1	0	0
UNC13D	201294	broad.mit.edu	37	17	73831510	73831510	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr17:73831510G>A	ENST00000207549.4	-	20	2207	c.1828C>T	c.(1828-1830)Cgc>Tgc	p.R610C	UNC13D_ENST00000412096.2_Missense_Mutation_p.R610C	NM_199242.2	NP_954712.1	Q70J99	UN13D_HUMAN	unc-13 homolog D (C. elegans)	610	MHD1.				positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGCACAGCGCGCTGCACCCGC	0.677000									Familial Hemophagocytic Lymphohistiocytosis				3	13					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146625847	146625847	+	Missense_Mutation	SNP	G	G	C			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr6:146625847G>C	ENST00000392299.2	+	4	1521	c.1051G>C	c.(1051-1053)Gat>Cat	p.D351H	GRM1_ENST00000492807.2_Missense_Mutation_p.D351H|GRM1_ENST00000355289.4_Missense_Mutation_p.D351H|GRM1_ENST00000361719.2_Missense_Mutation_p.D351H|GRM1_ENST00000282753.1_Missense_Mutation_p.D351H|GRM1_ENST00000507907.1_Missense_Mutation_p.D351H			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	351					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CAGGTCATTTGATGATTATTT	0.507000													11	12					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10356590	10356590	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr17:10356590G>A	ENST00000255381.2	-	24	3100	c.2990C>T	c.(2989-2991)aCc>aTc	p.T997I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	997					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CTTCTCCTTGGTCAGCTTAGC	0.478000													8	181					0	0	1	0	0
SLC2A11	66035	broad.mit.edu	37	22	24225971	24225971	+	Missense_Mutation	SNP	G	G	A	rs79905160	byFrequency	TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr22:24225971G>A	ENST00000345044.6	+	9	1265	c.997G>A	c.(997-999)Gag>Aag	p.E333K	SLC2A11_ENST00000398356.2_Missense_Mutation_p.E340K|SLC2A11_ENST00000316185.8_Missense_Mutation_p.E336K|AP000350.10_ENST00000433835.3_Intron			Q9BYW1	GTR11_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 11	333						integral to membrane|plasma membrane	sugar transmembrane transporter activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|skin(2)	12						TGTGGTAATCGAGAGGGTGGG	0.617000													24	37					0	0	1	0	0
FAM27L	284123	broad.mit.edu	37	17	21825425	21825425	+	RNA	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr17:21825425G>A	ENST00000426869.3	+	0	129					NR_028336.1				family with sequence similarity 27-like											central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)		tcggggctccgaggctccggc	0.622000													7	12					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114292293	114292293	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr7:114292293G>A	ENST00000393500.3	+	15	1725	c.905G>A	c.(904-906)aGc>aAc	p.S302N	FOXP2_ENST00000360232.4_Missense_Mutation_p.S377N|FOXP2_ENST00000393494.2_Missense_Mutation_p.S377N|FOXP2_ENST00000408937.3_Missense_Mutation_p.S402N|FOXP2_ENST00000393489.3_Missense_Mutation_p.S285N|FOXP2_ENST00000403559.4_Missense_Mutation_p.S394N|FOXP2_ENST00000393498.2_Missense_Mutation_p.S356N|FOXP2_ENST00000390668.3_Missense_Mutation_p.S401N|FOXP2_ENST00000393491.3_Missense_Mutation_p.S285N|FOXP2_ENST00000350908.4_Missense_Mutation_p.S377N			O15409	FOXP2_HUMAN	forkhead box P2	377				DLTTNNSSSTTSSNT -> EEFPVQGPAAVCAGL (in Ref. 10; AAB91439).	camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						GATGACCGAAGCACTGCTCAG	0.418000													5	52					0	0	1	0	0
ACCSL	390110	broad.mit.edu	37	11	44069708	44069708	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr11:44069708C>T	ENST00000378832.1	+	1	178	c.122C>T	c.(121-123)aCg>aTg	p.T41M		NM_001031854.2	NP_001027025.2	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like	41							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(14)|ovary(5)|pancreas(1)|skin(2)	34						CAGGCCATGACGGAGCACTTC	0.592000													15	21					0	0	1	0	0
ARRDC5	645432	broad.mit.edu	37	19	4902803	4902803	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr19:4902803G>A	ENST00000381781.2	-	1	76	c.77C>T	c.(76-78)cCc>cTc	p.P26L		NM_001080523.1	NP_001073992.1	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	26					signal transduction					endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		TCTATCCTCGGGCAGCACTAA	0.552000													38	54					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													5	31					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064067	9064067	+	Missense_Mutation	SNP	G	G	C			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr19:9064067G>C	ENST00000397910.4	-	3	23582	c.23379C>G	c.(23377-23379)gaC>gaG	p.D7793E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7795	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGGAGATGAGTCAGCTAGGA	0.502000													4	196					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150885275	150885275	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr5:150885275G>A	ENST00000261800.5	-	23	12913	c.12901C>T	c.(12901-12903)Cgc>Tgc	p.R4301C		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	4301					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CGGCTGAGGCGCATACCCACC	0.667000													3	43					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000405598.1_Silent_p.S372S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	43					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25959331	25959331	+	Silent	SNP	T	T	G			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr15:25959331T>G	ENST00000356865.6	-	10	1945	c.1834A>C	c.(1834-1836)Agg>Cgg	p.R612R		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	612					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGTGTGAACCTCCGCAGGAAG	0.597000													20	24					0	0	1	0	0
ZRANB1	54764	broad.mit.edu	37	10	126662251	126662251	+	Silent	SNP	A	A	G			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr10:126662251A>G	ENST00000359653.4	+	4	1565	c.1194A>G	c.(1192-1194)ttA>ttG	p.L398L		NM_017580.2	NP_060050.2	Q9UGI0	ZRAN1_HUMAN	zinc finger, RAN-binding domain containing 1	398	TRAF-binding.				positive regulation of Wnt receptor signaling pathway|protein K63-linked deubiquitination|Wnt receptor signaling pathway	aggresome|centrosome|intermediate filament cytoskeleton|nucleolus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	23		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.172)		Colorectal(40;0.113)|COAD - Colon adenocarcinoma(40;0.119)		AAGAAAAATTATTTGATGAGG	0.303000													4	207					0	0	1	0	0
IGKV3-7	0	broad.mit.edu	37	2	89277991	89277991	+	RNA	SNP	A	A	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr2:89277991A>T	ENST00000390247.2	-	0	440																											TGTGGGAGGTAAGTTATAATC	0.443000													12	14					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11051757	11051757	+	Missense_Mutation	SNP	T	T	G			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr16:11051757T>G	ENST00000409790.1	+	2	429	c.199T>G	c.(199-201)Tct>Gct	p.S67A	CLEC16A_ENST00000409552.3_Missense_Mutation_p.S67A	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	67										breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						AAATGACAGCTCTGTATTTGA	0.403000													4	83					0	0	1	0	0
SASH3	54440	broad.mit.edu	37	X	128927070	128927070	+	Silent	SNP	C	C	A	rs142835579		TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chrX:128927070C>A	ENST00000356892.3	+	7	1021	c.907C>A	c.(907-909)Cgg>Agg	p.R303R		NM_018990.3	NP_061863.1	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	303	SAM.							p.R303R(1)		breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	12						TCCACAGCACCGGGCCAAGCT	0.587000													21	0					7.45023e-12	7.71164e-12	1	1	0
RHOT1	55288	broad.mit.edu	37	17	30529851	30529851	+	Missense_Mutation	SNP	A	A	G			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr17:30529851A>G	ENST00000358365.3	+	15	1491	c.1264A>G	c.(1264-1266)Aat>Gat	p.N422D	RHOT1_ENST00000583994.1_Missense_Mutation_p.N295D|RHOT1_ENST00000545287.2_Missense_Mutation_p.N422D|RHOT1_ENST00000394692.2_Missense_Mutation_p.N422D|RHOT1_ENST00000354266.3_Missense_Mutation_p.N401D|RHOT1_ENST00000333942.6_Missense_Mutation_p.N422D|RHOT1_ENST00000581094.1_Missense_Mutation_p.N422D	NM_001033568.1	NP_001028740.1	Q8IXI2	MIRO1_HUMAN	ras homolog family member T1	422	Miro 2.				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			NS(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28		Myeloproliferative disorder(56;0.0255)|Breast(31;0.116)|Ovarian(249;0.182)				GTTCAGATGTAATGTAATTGG	0.313000													20	24					0	0	1	0	0
VPS11	55823	broad.mit.edu	37	11	118949846	118949846	+	Missense_Mutation	SNP	G	G	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr11:118949846G>T	ENST00000300793.6	+	15	2313	c.2271G>T	c.(2269-2271)caG>caT	p.Q757H	VPS11_ENST00000527798.1_3'UTR	NM_021729.4	NP_068375.3	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11 homolog (S. cerevisiae)	758					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	29	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		CAGTGGTGCAGACCCTGGCCC	0.552000													21	4					9.95505e-16	1.08768e-15	1	1	0
ANKHD1	54882	broad.mit.edu	37	5	139907827	139907827	+	Missense_Mutation	SNP	C	C	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr5:139907827C>A	ENST00000297183.6	+	29	5420	c.5296C>A	c.(5296-5298)Cct>Act	p.P1766T	ANKHD1_ENST00000360839.2_Missense_Mutation_p.P1766T|ANKHD1_ENST00000544120.1_Missense_Mutation_p.P149T|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.P1766T	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATTCAAGATCCTGCTAAGGA	0.383000													28	39					7.26314e-15	7.79137e-15	1	1	0
RUFY2	55680	broad.mit.edu	37	10	70105526	70105526	+	Nonstop_Mutation	SNP	C	C	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr10:70105526C>A	ENST00000388768.2	-	18	2251	c.1925G>T	c.(1924-1926)tGa>tTa	p.*642L	RUFY2_ENST00000602465.1_Nonstop_Mutation_p.*607L|RUFY2_ENST00000265865.3_Nonstop_Mutation_p.*197L	NM_017987.4	NP_060457.4	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain containing 2	0						nucleus	metal ion binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(2)	20						TCTGGAGTCTCAGGGCAAGTT	0.423000													24	37					1.22574e-08	1.24687e-08	1	1	0
CDH11	1009	broad.mit.edu	37	16	65038589	65038589	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr16:65038589C>T	ENST00000394156.3	-	3	637	c.184G>A	c.(184-186)Gtg>Atg	p.V62M	CDH11_ENST00000566827.1_Intron|CDH11_ENST00000569624.1_5'UTR|CDH11_ENST00000268603.4_Missense_Mutation_p.V62M			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	62	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TCCTCTATCACGAAGAACTGG	0.612000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			10	1					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120976076	120976076	+	Silent	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr3:120976076G>A	ENST00000273666.6	+	17	1999	c.1728G>A	c.(1726-1728)ccG>ccA	p.P576P	STXBP5L_ENST00000472879.1_Silent_p.P576P|STXBP5L_ENST00000471454.1_Silent_p.P576P|STXBP5L_ENST00000492541.1_Silent_p.P576P|STXBP5L_ENST00000497029.1_Silent_p.P576P	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	576					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		CAAGTCCTCCGTTTCCAGATC	0.393000													8	131					0	0	1	0	0
CHMP4B	128866	broad.mit.edu	37	20	32441333	32441333	+	Missense_Mutation	SNP	G	G	C			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr20:32441333G>C	ENST00000217402.2	+	5	807	c.642G>C	c.(640-642)atG>atC	p.M214I		NM_176812.4	NP_789782.1	Q9H444	CHM4B_HUMAN	charged multivesicular body protein 4B	214					cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13						ACGACGACATGAAGGAATTGG	0.557000													15	11					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977327	29977327	+	RNA	SNP	T	T	C	rs143365191	by1000genomes	TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr6:29977327T>C	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|HLA-J_ENST00000462773.1_RNA																							GACAGCTGCCTTGTGTGGGAC	0.438000													3	35					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225698898	225698898	+	Missense_Mutation	SNP	T	T	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr2:225698898T>A	ENST00000409592.3	-	26	3028	c.2915A>T	c.(2914-2916)aAt>aTt	p.N972I	DOCK10_ENST00000258390.7_Missense_Mutation_p.N978I			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	978							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TGTTGAGTCATTTGATTTCAA	0.403000													33	35					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|HLA-J_ENST00000462773.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													3	32					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42473001	42473001	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr19:42473001C>T	ENST00000545399.1	-	20	2947	c.2794G>A	c.(2794-2796)Gtc>Atc	p.V932I	ATP1A3_ENST00000543770.1_Missense_Mutation_p.V930I|ATP1A3_ENST00000302102.5_Missense_Mutation_p.V919I|ATP1A3_ENST00000602133.1_Missense_Mutation_p.V889I	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	919					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						GCCCACTGGACGACAACGATG	0.607000													28	19					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								4	45					0	0	1	0	0
DDX54	79039	broad.mit.edu	37	12	113612881	113612881	+	Silent	SNP	G	G	A			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr12:113612881G>A	ENST00000314045.7	-	8	861	c.834C>T	c.(832-834)tcC>tcT	p.S278S	DDX54_ENST00000306014.5_Silent_p.S278S	NM_001111322.1	NP_001104792.1	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	278	Helicase ATP-binding.				estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GCAGCGTGGCGGAGAACAGCA	0.667000											OREG0022139	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	26					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43279996	43279996	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr10:43279996C>T	ENST00000374518.4	+	2	217	c.154C>T	c.(154-156)Cgg>Tgg	p.R52W		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	52					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GTCTGCTGTGCGGATGGCTCG	0.463000													26	32					0	0	1	0	0
RBP1	5947	broad.mit.edu	37	3	139258317	139258318	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr3:139258317_139258318delAC	ENST00000483943.2	-	1	243_244	c.243_244delGT	c.(241-246)gaacfs	p.EY81fs	RBP1_ENST00000492918.1_Frame_Shift_Del_p.EY81fs|RP11-319G6.1_ENST00000515247.1_RNA|RBP1_ENST00000232219.2_Frame_Shift_Del_p.EY81fs	NM_001130993.1	NP_001124465.1	P09455	RET1_HUMAN	retinol binding protein 1, cellular	19						cytoplasm	retinal binding|retinol binding|transporter activity			endometrium(1)|large_intestine(2)|lung(1)|prostate(1)	5					Vitamin A(DB00162)	GCGCGCAGGTACTCCTCGAAAT	0.673													11	2	---	---	---	---					
BNIP1	662	broad.mit.edu	37	5	172578611	172578611	+	Frame_Shift_Del	DEL	T	T	-			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr5:172578611delT	ENST00000231668.9	+	3	324	c.220delT	c.(220-222)ttfs	p.F76fs	BNIP1_ENST00000393770.4_Intron|BNIP1_ENST00000352523.6_Frame_Shift_Del_p.F76fs|BNIP1_ENST00000351486.5_Intron	NM_013979.2	NP_053582.2	Q12981	SEC20_HUMAN	BCL2/adenovirus E1B 19kDa interacting protein 1	59					anti-apoptosis|apoptosis|endoplasmic reticulum membrane fusion|endoplasmic reticulum organization|induction of apoptosis|vesicle-mediated transport	integral to endoplasmic reticulum membrane|nuclear envelope|SNARE complex	protein binding			breast(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)|skin(1)	11	Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TGCTTCCACATTTTTTTTTAA	0.348													8	90	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	62038573	62038574	+	Frame_Shift_Ins	INS	-	-	T			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr10:62038573_62038574insT	ENST00000280772.1	-	4	563_564	c.372_373insA	c.(370-375)aatcttfs	p.NL124fs	ANK3_ENST00000503366.1_Frame_Shift_Ins_p.NL107fs|ANK3_ENST00000373827.2_Frame_Shift_Ins_p.NL118fs	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	124					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GTAACCAAGACTTTTACCACCT	0.396													86	79	---	---	---	---					
DDX23	9416	broad.mit.edu	37	12	49231321	49231321	+	Frame_Shift_Del	DEL	G	G	-			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr12:49231321delG	ENST00000308025.3	-	7	818	c.739delC	c.(739-741)tgfs	p.L247fs	DDX23_ENST00000553182.1_Intron	NM_004818.2	NP_004809.2	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	247						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			NS(1)|cervix(1)|kidney(4)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(3)	36						ATGGCATGCAGTTCCTTGCTC	0.502													70	64	---	---	---	---					
TRAV26-2	0	broad.mit.edu	37	14	22670555	22670567	+	RNA	DEL	TAATGACAAAAGA	TAATGACAAAAGA	-			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr14:22670555_22670567delTAATGACAAAAGA	ENST00000390460.1	+	0	40																											GTTTTGTGGCTAATGACAAAAGAGAGTTATCTG	0.404													8	5	---	---	---	---					
HERC2P2	0	broad.mit.edu	37	15	23312380	23312380	+	RNA	DEL	T	T	-			TCGA-YL-A8S9-01A-11D-A377-08	TCGA-YL-A8S9-10A-01D-A37A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	291c97ad-143c-40b6-9405-7b75ab8e23e4	b2e52658-fe9d-4212-b9e5-eedc1dff76f3	g.chr15:23312380delT	ENST00000560464.1	-	0	3118																											TGTTAttttcttttttttttt	0.398													4	9	---	---	---	---