Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HPCAL4	51440	broad.mit.edu	37	1	40149730	40149730	+	Missense_Mutation	SNP	A	A	T			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr1:40149730A>T	ENST00000372844.3	-	3	648	c.257T>A	c.(256-258)aTc>aAc	p.I86N		NM_016257.2	NP_057341.1	Q9UM19	HPCL4_HUMAN	hippocalcin like 4	86	EF-hand 2.				central nervous system development	intracellular	calcium ion binding			breast(1)|central_nervous_system(1)|lung(5)|stomach(1)	8	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CAGGGCGCAGATGAACTCCCG	0.642000													9	18					0	0	1	0	0
HLA-C	3107	broad.mit.edu	37	6	31239513	31239513	+	Missense_Mutation	SNP	C	C	T	rs41548913		TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr6:31239513C>T	ENST00000383329.3	-	2	220	c.206G>A	c.(205-207)gGg>gAg	p.G69E	HLA-C_ENST00000376228.5_Missense_Mutation_p.G69E			Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	69	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex		p.G69E(5)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	17						CCGCGGCTCCCCTCTCGGACT	0.697000													3	43					0	0	1	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891854	5891854	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr18:5891854G>A	ENST00000581347.1	-	3	854	c.209C>T	c.(208-210)gCg>gTg	p.A70V	RP11-945C19.4_ENST00000577694.1_RNA|TMEM200C_ENST00000383490.2_Missense_Mutation_p.A70V			A6NKL6	T200C_HUMAN	transmembrane protein 200C	70						integral to membrane		p.A70V(1)		autonomic_ganglia(1)|endometrium(1)|large_intestine(4)|lung(5)|stomach(1)	12						GCCCACCACCGCCATGGCTAT	0.662000													18	25					0	0	1	0	0
PDGFD	80310	broad.mit.edu	37	11	104034551	104034551	+	Silent	SNP	G	G	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr11:104034551G>A	ENST00000302251.5	-	1	556	c.105C>T	c.(103-105)aaC>aaT	p.N35N	PDGFD_ENST00000393158.2_Silent_p.N35N	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	35					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		TGAGGTTGGCGTTGCGCAAAG	0.423000											OREG0021315	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	30					0	0	1	0	0
CAV2	858	broad.mit.edu	37	7	116140406	116140406	+	Silent	SNP	A	A	G			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr7:116140406A>G	ENST00000222693.4	+	2	635	c.243A>G	c.(241-243)aaA>aaG	p.K81K	CAV2_ENST00000343213.2_Intron|CAV2_ENST00000462876.1_3'UTR|CAV2_ENST00000393480.2_Silent_p.K81K	NM_001206747.1|NM_001206748.1|NM_001233.4	NP_001193676.1|NP_001193677.1|NP_001224.1	P51636	CAV2_HUMAN	caveolin 2	81					caveola assembly|endoplasmic reticulum organization|mitochondrion organization|negative regulation of endothelial cell proliferation|positive regulation of dopamine receptor signaling pathway|regulation of mitosis|skeletal muscle fiber development|vesicle docking|vesicle fusion	caveola|extrinsic to internal side of plasma membrane|Golgi membrane|integral to plasma membrane|membrane fraction|nucleus|perinuclear region of cytoplasm|transport vesicle	D1 dopamine receptor binding|protein homodimerization activity			large_intestine(1)|lung(1)|skin(1)	3	all_epithelial(6;1.53e-06)|Lung NSC(10;0.00592)|all_lung(10;0.00642)		STAD - Stomach adenocarcinoma(10;0.00878)			AAATCAGCAAATACGTAATGT	0.532000													4	40					0	0	1	0	0
WNT3A	89780	broad.mit.edu	37	1	228210491	228210491	+	Missense_Mutation	SNP	C	C	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr1:228210491C>A	ENST00000284523.1	+	2	273	c.195C>A	c.(193-195)agC>agA	p.S65R	WNT3A_ENST00000366753.2_Missense_Mutation_p.S65R	NM_033131.3	NP_149122.1	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family, member 3A	65					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				TCATGCCCAGCGTGGCCGAGG	0.652000													3	28					0.115264	0.115264	1	1	0
CNTN6	27255	broad.mit.edu	37	3	1371511	1371511	+	Missense_Mutation	SNP	C	C	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr3:1371511C>A	ENST00000446702.2	+	11	1883	c.1256C>A	c.(1255-1257)tCt>tAt	p.S419Y	CNTN6_ENST00000350110.2_Missense_Mutation_p.S419Y|CNTN6_ENST00000539053.1_Missense_Mutation_p.S347Y			Q9UQ52	CNTN6_HUMAN	contactin 6	419	Ig-like C2-type 5.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAAAAAAAGTCTTTTGTTCAA	0.383000													24	41					1.1804e-14	1.28304e-14	1	1	0
TTLL5	23093	broad.mit.edu	37	14	76147908	76147908	+	Missense_Mutation	SNP	A	A	G			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr14:76147908A>G	ENST00000298832.9	+	4	407	c.202A>G	c.(202-204)Aag>Gag	p.K68E	TTLL5_ENST00000557636.1_Missense_Mutation_p.K68E|TTLL5_ENST00000556977.1_Missense_Mutation_p.K68E|TTLL5_ENST00000286650.5_Missense_Mutation_p.K68E	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	68	TTL.				protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		TTTGTCTTATAAGATTGTACG	0.343000													5	79					0	0	1	0	0
ALCAM	214	broad.mit.edu	37	3	105086325	105086325	+	Splice_Site	SNP	G	G	C			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr3:105086325G>C	ENST00000306107.5	+	1	573	c.73_splice	c.e1+1	p.G25_splice	ALCAM_ENST00000472644.2_Splice_Site_p.G25_splice	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	25					cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						CTTCAGGCCAGGTGAGCAAGG	0.652000													5	11					0	0	1	0	0
MSH4	4438	broad.mit.edu	37	1	76333274	76333274	+	Splice_Site	SNP	G	G	T			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr1:76333274G>T	ENST00000263187.3	+	9	1409		c.e9+1			NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4						chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						TCCTTTAAAGGTAATTTATGT	0.294000								Mismatch excision repair (MMR)					8	19					1.12685e-05	1.1738e-05	1	1	0
STAT4	6775	broad.mit.edu	37	2	191937909	191937909	+	Missense_Mutation	SNP	A	A	G			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr2:191937909A>G	ENST00000392320.2	-	5	694	c.380T>C	c.(379-381)cTa>cCa	p.L127P	STAT4_ENST00000358470.4_Missense_Mutation_p.L127P	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	127					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			GGATTTCTCTAGAGGCCCCTG	0.398000													49	58					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100676840	100676840	+	Missense_Mutation	SNP	A	A	T			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr7:100676840A>T	ENST00000306151.4	+	3	2207	c.2143A>T	c.(2143-2145)Acc>Tcc	p.T715S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	715	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCTGTTGACACCAGCACACC	0.498000													5	328					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116446367	116446367	+	Silent	SNP	T	T	C			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr12:116446367T>C	ENST00000281928.3	-	10	2057	c.1851A>G	c.(1849-1851)ttA>ttG	p.L617L		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	617					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		TCCCACAATATAAGGCTGTCT	0.522000													18	11					0	0	1	0	0
KRT33B	3884	broad.mit.edu	37	17	39521167	39521167	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr17:39521167C>T	ENST00000251646.3	-	6	1010	c.961G>A	c.(961-963)Gtg>Atg	p.V321M		NM_002279.4	NP_002270.1	Q14525	KT33B_HUMAN	keratin 33B	321	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|lung(6)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000496)				TGGGACTCCACGTTGGTGATC	0.612000													5	46					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57109973	57109973	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr12:57109973C>T	ENST00000454682.1	-	3	5622	c.5341G>A	c.(5341-5343)Gtc>Atc	p.V1781I	NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000550952.1_Missense_Mutation_p.V628I|NACA_ENST00000548563.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TTAGGAAGGACCTTCTCAAAG	0.557000			T	BCL6	NHL								13	15					0	0	1	0	0
KCNA2	3737	broad.mit.edu	37	1	111146236	111146236	+	Missense_Mutation	SNP	A	A	G			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr1:111146236A>G	ENST00000485317.1	-	3	1842	c.1169T>C	c.(1168-1170)gTg>gCg	p.V390A	KCNA2_ENST00000440270.1_Missense_Mutation_p.V390A|KCNA2_ENST00000316361.4_Missense_Mutation_p.V390A|KCNA2_ENST00000369770.3_Intron			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	390						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		TAGGGAACCCACTATCTTTCC	0.517000													5	59					0	0	1	0	0
MS4A6A	64231	broad.mit.edu	37	11	59942906	59942906	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr11:59942906G>A	ENST00000528851.1	-	5	658	c.518C>T	c.(517-519)aCg>aTg	p.T173M	MS4A6A_ENST00000533023.1_Intron|MS4A6A_ENST00000323961.3_Missense_Mutation_p.T173M|MS4A6A_ENST00000426738.2_Missense_Mutation_p.T128M|MS4A6A_ENST00000529054.1_Missense_Mutation_p.T201M|MS4A6A_ENST00000530839.1_Missense_Mutation_p.T173M|MS4A6A_ENST00000420732.2_Intron|MS4A6A_ENST00000412309.2_Missense_Mutation_p.T201M			Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member 6A	173						integral to membrane	receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ATAGCAGTCCGTGGTATAAAG	0.368000													13	11					0	0	1	0	0
C9orf156	51531	broad.mit.edu	37	9	100678519	100678519	+	Missense_Mutation	SNP	A	A	C			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr9:100678519A>C	ENST00000375119.3	-	2	254	c.178T>G	c.(178-180)Ttg>Gtg	p.L60V	C9orf156_ENST00000478126.1_Intron	NM_016481.3	NP_057565.3	Q9BU70	NAP1_HUMAN	chromosome 9 open reading frame 156	60					interspecies interaction between organisms		hydrolase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)	13		Acute lymphoblastic leukemia(62;0.158)				CTAATCCTCAAACAGGCTCGA	0.408000													3	46					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151131069	151131069	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chrX:151131069C>T	ENST00000370325.1	-	4	442	c.389G>A	c.(388-390)cGc>cAc	p.R130H	GABRE_ENST00000393914.3_5'UTR|GABRE_ENST00000370328.3_Missense_Mutation_p.R130H			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	130					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					GTAACAGAGGCGTTCGTCGTA	0.468000													34	6					0	0	1	0	0
ACOX1	51	broad.mit.edu	37	17	73953635	73953635	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr17:73953635C>T	ENST00000537812.1	-	4	977	c.329G>A	c.(328-330)cGa>cAa	p.R110Q	ACOX1_ENST00000591857.1_5'UTR|ACOX1_ENST00000301608.4_Missense_Mutation_p.R148Q|ACOX1_ENST00000293217.5_Missense_Mutation_p.R148Q	NM_001185039.1	NP_001171968.1	Q15067	ACOX1_HUMAN	acyl-CoA oxidase 1, palmitoyl	148					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(1)	14						TTCCAAGCCTCGAAGGTGAGT	0.448000													21	22					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14850219	14850219	+	Silent	SNP	T	T	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr18:14850219T>A	ENST00000358984.4	+	35	3225	c.3045T>A	c.(3043-3045)acT>acA	p.T1015T		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1100										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						GCAGATTGACTTTAAATCAAG	0.284000													11	5					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120668	38120668	+	Missense_Mutation	SNP	A	A	G			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr22:38120668A>G	ENST00000406386.3	+	7	2360	c.2105A>G	c.(2104-2106)cAa>cGa	p.Q702R	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	702					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					TCCTGTGCCCAACGGGACGAT	0.582000													3	42					0	0	1	0	0
UBA2	10054	broad.mit.edu	37	19	34935916	34935916	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr19:34935916G>A	ENST00000439527.2	+	8	871	c.373G>A	c.(373-375)Gaa>Aaa	p.E125K	UBA2_ENST00000246548.4_Missense_Mutation_p.E221K			Q9UBT2	SAE2_HUMAN	ubiquitin-like modifier activating enzyme 2	221					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	20	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			GGAACCAACGGAAGCCGAAGC	0.363000													16	61					0	0	1	0	0
ACTN2	88	broad.mit.edu	37	1	236882229	236882229	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr1:236882229C>T	ENST00000366578.4	+	3	443	c.277C>T	c.(277-279)Cgg>Tgg	p.R93W	ACTN2_ENST00000542672.1_Missense_Mutation_p.R93W|ACTN2_ENST00000492634.1_3'UTR	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	93	Actin-binding.|CH 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GGGAAAAATGCGGTTCCACAA	0.483000													3	42					0	0	1	0	0
TRIM48	79097	broad.mit.edu	37	11	55035844	55035844	+	Missense_Mutation	SNP	T	T	C			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr11:55035844T>C	ENST00000417545.2	+	4	660	c.574T>C	c.(574-576)Tac>Cac	p.Y192H		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	176						intracellular	zinc ion binding	p.Y192H(11)|p.Y176H(11)		endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						AGACATATTATACAGGTGAGT	0.338000													3	35					0	0	1	0	0
TRAF3IP2	10758	broad.mit.edu	37	6	111888850	111888850	+	Missense_Mutation	SNP	A	A	T			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr6:111888850A>T	ENST00000368761.5	-	6	1814	c.1336T>A	c.(1336-1338)Tgg>Agg	p.W446R	TRAF3IP2-AS1_ENST00000438298.2_RNA|TRAF3IP2-AS1_ENST00000449449.2_RNA|TRAF3IP2-AS1_ENST00000606892.1_RNA|TRAF3IP2_ENST00000359831.4_Missense_Mutation_p.W446R|TRAF3IP2_ENST00000340026.6_Missense_Mutation_p.W455R|TRAF3IP2_ENST00000368731.2_5'UTR|TRAF3IP2-AS1_ENST00000440395.1_RNA|TRAF3IP2-AS1_ENST00000532353.1_RNA|TRAF3IP2-AS1_ENST00000456352.2_RNA|TRAF3IP2-AS1_ENST00000442928.2_RNA|TRAF3IP2_ENST00000392556.4_Missense_Mutation_p.W34R	NM_001164281.2|NM_147686.3	NP_001157753.1|NP_679211.2	O43734	CIKS_HUMAN	TRAF3 interacting protein 2	455	SEFIR.				intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	18		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		CGCTCCATCCATTTAATGATA	0.373000													23	31					0	0	1	0	0
AASS	10157	broad.mit.edu	37	7	121758446	121758446	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr7:121758446G>A	ENST00000393376.1	-	5	697	c.602C>T	c.(601-603)gCt>gTt	p.A201V	AASS_ENST00000473553.1_Intron|AASS_ENST00000417368.2_Missense_Mutation_p.A201V			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	201	Lysine-ketoglutarate reductase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	TTCATAGCCAGCATCACGGAC	0.423000													3	61					0	0	1	0	0
OR5L1	219437	broad.mit.edu	37	11	55579447	55579447	+	Missense_Mutation	SNP	T	T	C			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr11:55579447T>C	ENST00000333973.2	+	1	594	c.505T>C	c.(505-507)Tat>Cat	p.Y169H		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				GATCCCCTTCTATAGATCTAA	0.453000													70	73					0	0	1	0	0
SDHAP3	0	broad.mit.edu	37	5	1593261	1593261	+	RNA	SNP	A	A	T			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr5:1593261A>T	ENST00000436493.2	-	0	364																											CTCAGGGCACATGCCTGACCA	0.542000													3	29					0	0	1	0	0
PCDHA11	0	broad.mit.edu	37	5	140250402	140250402	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr5:140250402G>A	ENST00000398640.2	+	1	1714	c.1714G>A	c.(1714-1716)Gcg>Acg	p.A572T	PCDHA5_ENST00000529859.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCTGGCAGCGCGGGAGGCGC	0.677000													11	117					0	0	1	0	0
RGPD8	727851	broad.mit.edu	37	2	113127775	113127775	+	Missense_Mutation	SNP	G	G	C			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr2:113127775G>C	ENST00000302558.3	-	23	5469	c.5278C>G	c.(5278-5280)Cct>Gct	p.P1760A	RGPD8_ENST00000409750.1_Missense_Mutation_p.P1620A	NM_001164463.1	NP_001157935.1			RANBP2-like and GRIP domain containing 8									p.P1760A(12)		endometrium(4)|kidney(1)|lung(1)|prostate(3)|urinary_tract(1)	10						GAACGGGAAGGATTTTCTTCC	0.308000													4	60					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628301	29628301	+	Silent	SNP	T	T	C			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr20:29628301T>C	ENST00000278882.3	+	6	683	c.303T>C	c.(301-303)agT>agC	p.S101S	FRG1B_ENST00000358464.4_Silent_p.S101S|FRG1B_ENST00000439954.2_Silent_p.S106S																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AAGCAAAAAGTAAAACAGCAG	0.353000													5	41					0	0	1	0	0
LGI4	163175	broad.mit.edu	37	19	35616120	35616120	+	Missense_Mutation	SNP	G	G	C			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr19:35616120G>C	ENST00000310123.3	-	9	2110	c.1591C>G	c.(1591-1593)Cac>Gac	p.H531D	LGI4_ENST00000392225.3_3'UTR|LGI4_ENST00000493050.1_5'UTR	NM_139284.2	NP_644813.1	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	531						extracellular region				endometrium(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			TCGATCTCGTGATGCTGGTAG	0.642000													5	39					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113331065	113331065	+	Splice_Site	SNP	C	C	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr8:113331065C>A	ENST00000297405.5	-	47	7605		c.e47+1		CSMD3_ENST00000352409.3_Splice_Site|CSMD3_ENST00000343508.3_Splice_Site|CSMD3_ENST00000455883.2_Splice_Site	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3							integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CCATTGAATACCTTGACAAAC	0.318000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			24	11					3.08376e-08	3.2806e-08	1	1	0
GLDC	2731	broad.mit.edu	37	9	6554737	6554737	+	Silent	SNP	G	G	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr9:6554737G>A	ENST00000321612.6	-	19	2397	c.2247C>T	c.(2245-2247)caC>caT	p.H749H		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	749					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GAAGATTTAGGTGCGAGACAT	0.557000													6	7					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													4	46					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151932975	151932975	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr7:151932975G>A	ENST00000355193.2	-	16	2914	c.2696C>T	c.(2695-2697)gCa>gTa	p.A899V	KMT2C_ENST00000262189.6_Missense_Mutation_p.A899V					lysine (K)-specific methyltransferase 2C																		CGACAGTCCTGCACCTCGAGG	0.483000													6	68					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								6	45					0	0	1	0	0
CHST8	64377	broad.mit.edu	37	19	34263027	34263027	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr19:34263027C>T	ENST00000262622.3	+	4	1092	c.334C>T	c.(334-336)Cgc>Tgc	p.R112C	CHST8_ENST00000438847.2_Missense_Mutation_p.R112C|CHST8_ENST00000434302.1_Missense_Mutation_p.R112C	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	112					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					CCAGCGCCGTCGCCGTCTGCT	0.711000													5	19					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28847368	28847368	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr16:28847368G>A	ENST00000336783.4	+	22	3177	c.3010G>A	c.(3010-3012)Gcg>Acg	p.A1004T	RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000382686.4_Missense_Mutation_p.A1004T|ATXN2L_ENST00000564304.1_Missense_Mutation_p.A1010T|ATXN2L_ENST00000570200.1_Missense_Mutation_p.A1004T|ATXN2L_ENST00000395547.2_Missense_Mutation_p.A1004T|ATXN2L_ENST00000340394.8_Missense_Mutation_p.A1004T|ATXN2L_ENST00000325215.6_Missense_Mutation_p.A1004T	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	1004						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						CCCCCAAGGCGCGGTGCCCCA	0.706000													27	27					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977327	29977327	+	RNA	SNP	T	T	C	rs143365191	by1000genomes	TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr6:29977327T>C	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA																							GACAGCTGCCTTGTGTGGGAC	0.438000													3	54					0	0	1	0	0
MLXIP	22877	broad.mit.edu	37	12	122620180	122620180	+	Frame_Shift_Del	DEL	G	G	-			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr12:122620180delG	ENST00000319080.6	+	11	2131	c.1999delG	c.(1999-2001)ggfs	p.G668fs	MLXIP_ENST00000538698.1_Frame_Shift_Del_p.G275fs			Q9HAP2	MLXIP_HUMAN	MLX interacting protein	668					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		CCCGCTGCATGGGGGCAGCCC	0.677													2	4	---	---	---	---					
PRPF8	10594	broad.mit.edu	37	17	1577185	1577216	+	Splice_Site	DEL	ACCTACACCAGACCAGGTACACTGCTGAGGCC	ACCTACACCAGACCAGGTACACTGCTGAGGCC	-			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr17:1577185_1577216delACCTACACCAGACCAGGTACACTGCTGAGGCC	ENST00000572621.1	-	21	3565_3566	c.3299_splice	c.e21-1	p.S1100_splice	PRPF8_ENST00000304992.6_Splice_Site_p.S1100_splice			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1100						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TCTGCTGTGAACCTACACCAGACCAGGTACACTGCTGAGGCCCCAGTACACT	0.530													8	56	---	---	---	---					
CTD-2206N4.4	0	broad.mit.edu	37	17	37213525	37213526	+	RNA	INS	-	-	TTTTG	rs59291335		TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chr17:37213525_37213526insTTTTG	ENST00000583447.1	+	0	141					NR_036551.1																						CTGAAGGACTCttttttttttt	0.550													2	4	---	---	---	---					
HDAC6	10013	broad.mit.edu	37	X	48673084	48673084	+	Frame_Shift_Del	DEL	G	G	-			TCGA-YL-A9WL-01A-11D-A41K-08	TCGA-YL-A9WL-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bc2626e6-65db-4905-97c5-46d61ea9e208	9b13b9bb-48e7-4bb4-81d0-3ce62ee0e536	g.chrX:48673084delG	ENST00000334136.5	+	12	1114	c.936delG	c.(934-936)gtfs	p.V312fs	HDAC6_ENST00000413163.2_Frame_Shift_Del_p.V257fs|HDAC6_ENST00000376619.2_Frame_Shift_Del_p.V312fs|HDAC6_ENST00000444343.2_Frame_Shift_Del_p.V326fs			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	312	Histone deacetylase 1.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	GTCTGCAGGTGGGGATGCGGG	0.642													2	4	---	---	---	---