Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF92	168374	broad.mit.edu	37	7	64863705	64863705	+	Silent	SNP	A	A	G			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr7:64863705A>G	ENST00000328747.7	+	4	877	c.678A>G	c.(676-678)gaA>gaG	p.E226E	ZNF92_ENST00000357512.2_Silent_p.E194E|ZNF92_ENST00000450302.2_Silent_p.E157E|ZNF92_ENST00000431504.1_Silent_p.E150E	NM_152626.2	NP_689839.1	Q03936	ZNF92_HUMAN	zinc finger protein 92	226						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				ATACTGGAGAAAAACCCTACA	0.338000													3	61					0	0	1	0	0
DCUN1D2	55208	broad.mit.edu	37	13	114128477	114128477	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr13:114128477G>A	ENST00000332592.3	-	2	117	c.83C>T	c.(82-84)aCc>aTc	p.T28I	DCUN1D2-AS_ENST00000414992.1_RNA|DCUN1D2_ENST00000478244.1_Missense_Mutation_p.T161I|DCUN1D2_ENST00000375399.2_Missense_Mutation_p.T161I			Q6PH85	DCNL2_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 2	161	UBA-like.									breast(1)|endometrium(1)|large_intestine(1)|lung(3)|stomach(1)	7	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.029)|GBM - Glioblastoma multiforme(44;0.234)			GAAGGTGAAGGTAAACTGATA	0.448000													4	98					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7780627	7780627	+	Silent	SNP	G	G	A			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr10:7780627G>A	ENST00000358415.4	+	16	2167	c.2001G>A	c.(1999-2001)ccG>ccA	p.P667P	ITIH2_ENST00000379587.4_Silent_p.P656P	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	667					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						ATTCCACCCCGTCTTGGGCCA	0.532000													8	58					0	0	1	0	0
BCL2L10	10017	broad.mit.edu	37	15	52402108	52402108	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr15:52402108G>A	ENST00000561198.1	-	2	663	c.622C>T	c.(622-624)Cca>Tca	p.P208S	BCL2L10_ENST00000260442.3_Silent_p.V184V			Q9HD36	B2L10_HUMAN	BCL2-like 10 (apoptosis facilitator)	0					activation of caspase activity|anti-apoptosis|female gamete generation|spermatogenesis	cytosol|integral to membrane|membrane fraction|mitochondrion|nuclear membrane	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	2				all cancers(107;0.0148)		GAAAAGCCTGGACCAGCTGTT	0.438000													4	97					0	0	1	0	0
EFCAB7	84455	broad.mit.edu	37	1	63999252	63999252	+	Missense_Mutation	SNP	C	C	T			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr1:63999252C>T	ENST00000371088.4	+	5	860	c.614C>T	c.(613-615)cCa>cTa	p.P205L		NM_032437.2	NP_115813.2	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	205							calcium ion binding			breast(1)|endometrium(4)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	19						GAAAGGGACCCATCACCAGTA	0.378000													5	118					0	0	1	0	0
PCDHA3	0	broad.mit.edu	37	5	140182441	140182441	+	Silent	SNP	G	G	A			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr5:140182441G>A	ENST00000522353.2	+	1	1659	c.1659G>A	c.(1657-1659)gtG>gtA	p.V553V	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000532566.2_Silent_p.V553V|PCDHA2_ENST00000520672.2_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCTGCAGGTGTTCGTGCTGG	0.682000													17	97					0	0	1	0	0
CBLL1	79872	broad.mit.edu	37	7	107394392	107394392	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr7:107394392G>A	ENST00000440859.2	+	4	802	c.335G>A	c.(334-336)tGt>tAt	p.C112Y	CBLL1_ENST00000222597.2_Missense_Mutation_p.C111Y|CBLL1_ENST00000415884.2_Missense_Mutation_p.C112Y	NM_024814.2	NP_079090.2	Q75N03	HAKAI_HUMAN	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase	112					cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(3)	21						TGTGACAAGTGTGGATTGCCT	0.299000													5	68					0	0	1	0	0
PARD3	56288	broad.mit.edu	37	10	34606223	34606223	+	Silent	SNP	A	A	T			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr10:34606223A>T	ENST00000374789.3	-	20	3211	c.2886T>A	c.(2884-2886)tcT>tcA	p.S962S	PARD3_ENST00000466092.1_5'UTR|PARD3_ENST00000340077.5_Silent_p.S959S|PARD3_ENST00000374790.3_Silent_p.S902S|PARD3_ENST00000346874.4_Silent_p.S962S|PARD3_ENST00000545260.1_Silent_p.S872S|PARD3_ENST00000374776.1_Silent_p.S916S|PARD3_ENST00000374788.3_Silent_p.S959S|PARD3_ENST00000374773.1_Silent_p.S929S|PARD3_ENST00000544292.1_Silent_p.S675S|PARD3_ENST00000350537.4_Silent_p.S916S|PARD3_ENST00000545693.1_Silent_p.S946S|PARD3_ENST00000374794.3_Silent_p.S887S	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	962					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				CTGTGGATACAGACTCTCTCC	0.398000													4	40					0	0	1	0	0
CUL2	8453	broad.mit.edu	37	10	35322104	35322104	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr10:35322104G>A	ENST00000374748.1	-	12	1413	c.1100C>T	c.(1099-1101)gCg>gTg	p.A367V	CUL2_ENST00000537177.1_Missense_Mutation_p.A386V|CUL2_ENST00000374746.1_Missense_Mutation_p.A367V|CUL2_ENST00000374742.1_Missense_Mutation_p.A367V|CUL2_ENST00000602371.1_Missense_Mutation_p.A310V|CUL2_ENST00000374751.3_Missense_Mutation_p.A367V|CUL2_ENST00000374749.3_Missense_Mutation_p.A367V			Q13617	CUL2_HUMAN	cullin 2	367					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|prostate(2)|skin(1)|urinary_tract(2)	31						CTTATCCAACGCACTCATAAA	0.323000													4	52					0	0	1	0	0
ENC1	8507	broad.mit.edu	37	5	73932281	73932281	+	Silent	SNP	C	C	T			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr5:73932281C>T	ENST00000302351.4	-	2	1160	c.30G>A	c.(28-30)aaG>aaA	p.K10K	ENC1_ENST00000537006.1_Silent_p.K10K|ENC1_ENST00000510316.1_Intron	NM_003633.3	NP_003624.1	O14682	ENC1_HUMAN	ectodermal-neural cortex 1 (with BTB domain)	10					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	20		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		TGGCCCTGGACTTGCGGTTCT	0.443000													5	38					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29633900	29633900	+	Missense_Mutation	SNP	A	A	G	rs60081496	by1000genomes	TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr20:29633900A>G	ENST00000278882.3	+	9	919	c.539A>G	c.(538-540)gAa>gGa	p.E180G	FRG1B_ENST00000358464.4_Missense_Mutation_p.E180G														p.E180G(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAAACAAGAGAACCAAATTGA	0.264000													5	53					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114269985	114269985	+	Silent	SNP	A	A	G			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr7:114269985A>G	ENST00000393500.3	+	11	1117	c.297A>G	c.(295-297)caA>caG	p.Q99Q	FOXP2_ENST00000393498.2_Silent_p.Q154Q|FOXP2_ENST00000393494.2_Silent_p.Q174Q|FOXP2_ENST00000408937.3_Silent_p.Q199Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000393489.3_Silent_p.Q82Q|FOXP2_ENST00000350908.4_Silent_p.Q174Q|FOXP2_ENST00000393491.3_Silent_p.Q82Q|FOXP2_ENST00000360232.4_Silent_p.Q174Q|FOXP2_ENST00000378237.3_Silent_p.Q174Q|FOXP2_ENST00000403559.4_Silent_p.Q191Q|FOXP2_ENST00000390668.3_Silent_p.Q198Q			O15409	FOXP2_HUMAN	forkhead box P2	174	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q199Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						aacaacaacaacagcagcaac	0.502000													3	38					0	0	1	0	0
SF3A3	10946	broad.mit.edu	37	1	38444715	38444715	+	Silent	SNP	G	G	A			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr1:38444715G>A	ENST00000373019.4	-	10	1727	c.772C>T	c.(772-774)Ctg>Ttg	p.L258L	SF3A3_ENST00000489537.1_5'UTR|SF3A3_ENST00000448721.2_Silent_p.L205L	NM_006802.2	NP_006793.1	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3, 60kDa	258					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(3)|prostate(2)	12	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TCCAAACCCAGAGAAGCCAAC	0.398000													5	63					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577548	7577548	+	Missense_Mutation	SNP	C	C	T	rs28934575		TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr17:7577548C>T	ENST00000420246.2	-	7	865	c.733G>A	c.(733-735)Ggc>Agc	p.G245S	TP53_ENST00000359597.4_Missense_Mutation_p.G245S|TP53_ENST00000413465.2_Missense_Mutation_p.G245S|TP53_ENST00000269305.4_Missense_Mutation_p.G245S|TP53_ENST00000455263.2_Missense_Mutation_p.G245S|TP53_ENST00000445888.2_Missense_Mutation_p.G245S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	245	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		G -> A (in sporadic cancers; somatic mutation).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(304)|p.G245C(59)|p.G245R(10)|p.G152S(8)|p.0?(8)|p.?(5)|p.G152C(4)|p.G244_M246>V(3)|p.G245N(2)|p.G245fs*2(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245fs*22(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.M243fs*18(1)|p.G151_M153>V(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577000	G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKLMS1_SOFT_TISSUE)|G245S(SKMEL2_SKIN)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			5	43					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53242522	53242522	+	Missense_Mutation	SNP	G	G	A			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr12:53242522G>A	ENST00000304620.4	-	1	256	c.193C>T	c.(193-195)Cgg>Tgg	p.R65W		NM_173352.2	NP_775487.2	Q8N1N4	K2C78_HUMAN	keratin 78	65	Gly-rich.|Head.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						TCCCCAAACCGCACCCCCAGC	0.637000													4	16					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123725995	123725995	+	Silent	SNP	T	T	C			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr9:123725995T>C	ENST00000223642.1	-	34	4271	c.4242A>G	c.(4240-4242)gaA>gaG	p.E1414E		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1414					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	CAGATGATGATTCTTCCCTGC	0.363000													11	95					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33581458	33581458	+	Splice_Site	SNP	G	G	A			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr11:33581458G>A	ENST00000321505.4	+	6	3307		c.e6+1		KIAA1549L_ENST00000389726.3_Splice_Site|KIAA1549L_ENST00000265654.5_Splice_Site					KIAA1549-like																		ATTGCTGAACGTGAGTATGGC	0.547000													21	162					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60498514	60498514	+	Silent	SNP	C	C	T			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr20:60498514C>T	ENST00000360469.5	+	10	1468	c.1380C>T	c.(1378-1380)gtC>gtT	p.V460V	CDH4_ENST00000543233.1_Silent_p.V386V	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	460	Cadherin 3.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			TCCAGGCAGTCGACTACGAGC	0.622000													9	70					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													3	23					0	0	1	0	0
TRBV5-6	0	broad.mit.edu	37	7	142131738	142131739	+	RNA	INS	-	-	A			TCGA-YL-A9WX-01A-21D-A41K-08	TCGA-YL-A9WX-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	19f982b5-db69-440a-815e-c90a923179c8	4be95b75-954e-4f4a-840e-f9fc6762bfc8	g.chr7:142131738_142131739insA	ENST00000390375.2	-	0	90																											ATGAGCACAGGGACAGCCTGGA	0.579													7	66	---	---	---	---