Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BSN	8927	broad.mit.edu	37	3	49662488	49662488	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr3:49662488C>T	ENST00000296452.4	+	2	419	c.305C>T	c.(304-306)aCc>aTc	p.T102I		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	102					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCTTCTGCTACCACTCCTGGC	0.602000													22	46					0	0	1	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86539140	86539140	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr7:86539140C>A	ENST00000450689.2	-	16	2532	c.2347G>T	c.(2347-2349)Gat>Tat	p.D783Y	KIAA1324L_ENST00000444627.1_Missense_Mutation_p.D712Y|KIAA1324L_ENST00000416314.1_Missense_Mutation_p.D616Y|KIAA1324L_ENST00000297222.6_Missense_Mutation_p.D543Y	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	783						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					ATGAATGTATCTGCCAGAATG	0.358000													42	55					3.05275e-18	3.24119e-18	1	1	0
NR1D1	9572	broad.mit.edu	37	17	38252187	38252187	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr17:38252187G>A	ENST00000246672.3	-	5	1388	c.758C>T	c.(757-759)tCg>tTg	p.S253L		NM_021724.3	NP_068370.1	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	253					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|large_intestine(5)|lung(2)|skin(1)|upper_aerodigestive_tract(2)	11	Colorectal(19;0.000442)					AGGGGGTGGCGAGGGGCCCAT	0.662000													7	20					0	0	1	0	0
PPAN	56342	broad.mit.edu	37	19	10224931	10224931	+	Silent	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr19:10224931C>T	ENST00000556468.1	+	13	1929	c.1902C>T	c.(1900-1902)tgC>tgT	p.C634C	PPAN-P2RY11_ENST00000393796.4_Silent_p.C634C|P2RY11_ENST00000321826.4_Silent_p.C214C|PPAN-P2RY11_ENST00000428358.1_3'UTR					peter pan homolog (Drosophila)											endometrium(3)|liver(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	15			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GGTTGGGCTGCGGCCTGCCGC	0.711000													17	33					0	0	1	0	0
EPO	2056	broad.mit.edu	37	7	100320382	100320382	+	Silent	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr7:100320382G>A	ENST00000252723.2	+	4	523	c.342G>A	c.(340-342)ccG>ccA	p.P114P		NM_000799.2	NP_000790.2	P01588	EPO_HUMAN	erythropoietin	114					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)|endometrium(2)|lung(7)|prostate(1)	12	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CTTCCCAGCCGTGGGAGCCCC	0.657000													7	27					0	0	1	0	0
ZNF777	27153	broad.mit.edu	37	7	149148162	149148162	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr7:149148162G>A	ENST00000247930.4	-	4	1338	c.1015C>T	c.(1015-1017)Cgc>Tgc	p.R339C		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	339	Glu-rich.|KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CGCTCCCCGCGCTCCATCTGT	0.537000													33	52					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155219106	155219106	+	Silent	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr4:155219106C>T	ENST00000357232.3	-	18	4994	c.4995G>A	c.(4993-4995)agG>agA	p.R1665R		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1665	Cadherin 14.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R1665R(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCGTGGTTGTCCTGGCTGGAA	0.433000													9	34					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21156286	21156286	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr22:21156286C>T	ENST00000255882.6	-	14	1785	c.1699G>A	c.(1699-1701)Gac>Aac	p.D567N	PI4KA_ENST00000572273.1_Missense_Mutation_p.D509N	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	509					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			ATAGCGATGTCTCGGAGCTGC	0.483000													25	78					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158592846	158592846	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:158592846C>T	ENST00000368148.3	-	43	6227	c.6047G>A	c.(6046-6048)cGc>cAc	p.R2016H	SPTA1_ENST00000461624.1_5'UTR|SPTA1_ENST00000368147.3_Missense_Mutation_p.R2013H	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2016					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.R2016H(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTGTTCCCAGCGCTTCAGCAG	0.478000													82	186					0	0	1	0	0
ST6GALNAC1	55808	broad.mit.edu	37	17	74621474	74621474	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr17:74621474C>T	ENST00000156626.7	-	9	1940	c.1741G>A	c.(1741-1743)Gat>Aat	p.D581N		NM_018414.3	NP_060884.1	Q9NSC7	SIA7A_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	581					protein glycosylation	integral to Golgi membrane	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	22						ATCCCTTCATCGTGTAGCCGC	0.532000													5	41					0	0	1	0	0
CHP2	63928	broad.mit.edu	37	16	23767170	23767170	+	Missense_Mutation	SNP	G	G	A	rs147617371	byFrequency	TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr16:23767170G>A	ENST00000300113.2	+	3	566	c.143G>A	c.(142-144)cGc>cAc	p.R48H		NM_022097.2	NP_071380.1	O43745	CHP2_HUMAN	calcineurin-like EF-hand protein 2	48	EF-hand 1.						calcium ion binding	p.R48H(1)		central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|stomach(1)	9				GBM - Glioblastoma multiforme(48;0.0144)		CTTTGCAGCCGCATGGATCTC	0.567000													9	33					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181680189	181680189	+	Silent	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:181680189C>T	ENST00000526775.1	+	8	1320	c.1155C>T	c.(1153-1155)gcC>gcT	p.A385A	CACNA1E_ENST00000357570.5_Silent_p.A336A|CACNA1E_ENST00000358338.5_Silent_p.A336A|CACNA1E_ENST00000367570.1_Silent_p.A385A|CACNA1E_ENST00000367567.4_5'UTR|CACNA1E_ENST00000367573.2_Silent_p.A385A|CACNA1E_ENST00000360108.3_Silent_p.A385A	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	385	Binding to the beta subunit (By similarity).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						GCTACCGTGCCTGGATAGACA	0.592000													16	44					0	0	1	0	0
NBL1	4681	broad.mit.edu	37	1	19981506	19981506	+	Splice_Site	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:19981506G>A	ENST00000289749.2	+	2	168	c.86_splice	c.e2-1	p.A30_splice	MINOS1-NBL1_ENST00000602662.1_5'UTR|NBL1_ENST00000375136.3_5'UTR|NBL1_ENST00000548815.1_5'UTR	NM_182744.3	NP_877421.2	P41271	NBL1_HUMAN	neuroblastoma 1, DAN family BMP antagonist	0						extracellular region				lung(2)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00043)|Ovarian(437;0.00373)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;5.9e-05)|Kidney(64;0.000173)|GBM - Glioblastoma multiforme(114;0.0012)|KIRC - Kidney renal clear cell carcinoma(64;0.0026)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCGTTCTAGGGCTCTGGAGGC	0.632000													7	16					0	0	1	0	0
VILL	50853	broad.mit.edu	37	3	38047368	38047368	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr3:38047368G>C	ENST00000283713.6	+	17	2302	c.2036G>C	c.(2035-2037)gGg>gCg	p.G679A	VILL_ENST00000465644.1_Missense_Mutation_p.G397A|VILL_ENST00000383759.2_Missense_Mutation_p.G679A			O15195	VILL_HUMAN	villin-like	679					actin filament capping|cytoskeleton organization	actin cytoskeleton	actin binding|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|stomach(3)|urinary_tract(2)	28				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		CACCCAGCAGGGAGGAGCCCG	0.612000													29	73					0	0	1	0	0
DPEP2	64174	broad.mit.edu	37	16	68025823	68025823	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr16:68025823C>T	ENST00000412757.2	-	6	1245	c.580G>A	c.(580-582)Gac>Aac	p.D194N	DPEP2_ENST00000393847.1_Missense_Mutation_p.D194N|DPEP2_ENST00000572888.1_Missense_Mutation_p.D194N			Q9H4A9	DPEP2_HUMAN	dipeptidase 2	194					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		AGGCTATTGTCCAGCGAGTGG	0.567000													12	48					0	0	1	0	0
TRAPPC10	7109	broad.mit.edu	37	21	45502929	45502929	+	Missense_Mutation	SNP	G	G	A	rs149129671	byFrequency	TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr21:45502929G>A	ENST00000291574.4	+	14	2159	c.1984G>A	c.(1984-1986)Gca>Aca	p.A662T		NM_003274.4	NP_003265.3	P48553	TPC10_HUMAN	trafficking protein particle complex 10	662					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(8)|ovary(1)|prostate(2)|skin(2)|urinary_tract(4)	41						ACCCGAGACCGCACCTTTCCC	0.483000													4	97					0	0	1	0	0
PLRG1	5356	broad.mit.edu	37	4	155467028	155467028	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr4:155467028G>A	ENST00000499023.2	-	6	578	c.452C>T	c.(451-453)cCt>cTt	p.P151L	PLRG1_ENST00000393905.2_Missense_Mutation_p.P151L|PLRG1_ENST00000302078.5_Missense_Mutation_p.P142L	NM_001201564.1|NM_002669.3	NP_001188493.1|NP_002660.1	O43660	PLRG1_HUMAN	pleiotropic regulator 1	151						catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|skin(1)|urinary_tract(1)	22	all_hematologic(180;0.215)	Renal(120;0.0854)				AGAAGCCCCAGGATGTCGGTA	0.423000													12	20					0	0	1	0	0
DDRGK1	65992	broad.mit.edu	37	20	3175950	3175950	+	Missense_Mutation	SNP	T	T	G			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr20:3175950T>G	ENST00000354488.3	-	5	617	c.560A>C	c.(559-561)gAg>gCg	p.E187A	DDRGK1_ENST00000380201.2_Missense_Mutation_p.E187A	NM_023935.1	NP_076424.1	Q96HY6	DDRGK_HUMAN	DDRGK domain containing 1	187						endoplasmic reticulum	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|skin(2)|urinary_tract(1)	7						CAGGTACTCCTCATGCTCCCG	0.627000													13	53					0	0	1	0	0
UBQLN4	56893	broad.mit.edu	37	1	156013896	156013896	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:156013896G>A	ENST00000368309.3	-	6	1111	c.1019C>T	c.(1018-1020)tCc>tTc	p.S340F	UBQLN4_ENST00000368307.1_Intron	NM_020131.3	NP_064516.2	Q9NRR5	UBQL4_HUMAN	ubiquilin 4	340						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)	16	Hepatocellular(266;0.133)|all_neural(408;0.195)					GGGGGCCTGGGAGGTGGGGGG	0.687000													8	15					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51705355	51705355	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr8:51705355C>T	ENST00000522124.1	+	19	2181	c.1520C>T	c.(1519-1521)tCt>tTt	p.S507F	SNTG1_ENST00000518864.1_Missense_Mutation_p.S507F|SNTG1_ENST00000276467.5_Missense_Mutation_p.S470F|SNTG1_ENST00000517473.1_Missense_Mutation_p.S470F	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	507					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GCTGCCAGCTCTGCTACCACG	0.428000													21	52					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37646964	37646964	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr17:37646964C>T	ENST00000447079.4	+	3	2119	c.2086C>T	c.(2086-2088)Caa>Taa	p.Q696*	CDK12_ENST00000430627.2_Nonsense_Mutation_p.Q696*	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	696					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						ACCACCTCAGCAACCATATAA	0.448000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			14	22					0	0	1	0	0
ATR	545	broad.mit.edu	37	3	142272702	142272702	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr3:142272702C>A	ENST00000350721.4	-	11	2618	c.2497G>T	c.(2497-2499)Gaa>Taa	p.E833*	ATR_ENST00000383101.3_Nonsense_Mutation_p.E769*	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	833					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TCCAAGGATTCCAATATGTGC	0.313000								Other conserved DNA damage response genes					7	33					0.307466	0.307466	1	1	0
HSPA8	3312	broad.mit.edu	37	11	122931348	122931348	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr11:122931348T>C	ENST00000534624.1	-	3	640	c.364A>G	c.(364-366)Atg>Gtg	p.M122V	HSPA8_ENST00000453788.2_Missense_Mutation_p.M122V|HSPA8_ENST00000227378.3_Missense_Mutation_p.M122V|HSPA8_ENST00000526110.1_Missense_Mutation_p.M122V|HSPA8_ENST00000532636.1_Missense_Mutation_p.M122V|HSPA8_ENST00000533540.1_Intron	NM_006597.4	NP_006588.1	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8	122					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			breast(1)|central_nervous_system(7)|endometrium(1)|kidney(9)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	36		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GTCAGAACCATAGAAGACACC	0.473000													13	66					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94486381	94486381	+	Missense_Mutation	SNP	G	G	C	rs141235720	byFrequency	TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr9:94486381G>C	ENST00000375708.3	-	9	2593	c.2395C>G	c.(2395-2397)Ccc>Gcc	p.P799A	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Intron	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	799	Pro-rich.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding	p.P799S(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						ATGAACTGGGGCTGTGGGAAG	0.672000													20	32					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43909116	43909116	+	Missense_Mutation	SNP	C	C	T	rs146439294		TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:43909116C>T	ENST00000562955.1	+	60	8422	c.8422C>T	c.(8422-8424)Ccc>Tcc	p.P2808S	SZT2_ENST00000372442.1_Missense_Mutation_p.P1966S	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2865						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GCTGCATGGGCCCCCAGAGAC	0.627000													14	14					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22389682	22389682	+	Silent	SNP	G	G	A	rs146569496		TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr4:22389682G>A	ENST00000334304.5	-	19	3881	c.3612C>T	c.(3610-3612)aaC>aaT	p.N1204N	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	1204					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				TAGGTAAGCCGTTCTGCACGC	0.522000													58	85					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	887225	887225	+	Silent	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr4:887225C>T	ENST00000314167.4	-	9	1040	c.930G>A	c.(928-930)gtG>gtA	p.V310V	GAK_ENST00000511163.1_Silent_p.V231V	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	310	Protein kinase.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		GCAGCTGGTGCACCACCTCGG	0.687000													6	40					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128446848	128446848	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr7:128446848G>A	ENST00000297788.4	+	9	1722	c.1355G>A	c.(1354-1356)tGc>tAc	p.C452Y	CCDC136_ENST00000464832.1_Intron|CCDC136_ENST00000378685.4_Intron|CCDC136_ENST00000487361.1_Missense_Mutation_p.C399Y	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	452						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						GAGCTGCAGTGCCATGAGGCA	0.577000													7	13					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117805041	117805041	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chrX:117805041G>A	ENST00000276204.6	+	46	5206	c.5132G>A	c.(5131-5133)cGt>cAt	p.R1711H	DOCK11_ENST00000276202.7_Missense_Mutation_p.R1711H			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1711	DHR-2.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						AAGGCAGAACGTTATGAAATA	0.348000													24	14					0	0	1	0	0
CEACAM7	1087	broad.mit.edu	37	19	42187837	42187837	+	Silent	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr19:42187837G>A	ENST00000006724.3	-	3	786	c.585C>T	c.(583-585)tcC>tcT	p.S195S	CEACAM7_ENST00000401731.1_Silent_p.S195S|CEACAM7_ENST00000338196.4_Intron|CEACAM7_ENST00000602225.1_Intron	NM_006890.3	NP_008821.1	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 7	195	Ig-like C2-type.					anchored to membrane|integral to membrane|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		TGTTGTCAGTGGAGAGCAGCA	0.512000													41	76					0	0	1	0	0
ZFP57	346171	broad.mit.edu	37	6	29640720	29640720	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr6:29640720A>G	ENST00000376883.1	-	6	1519	c.1108T>C	c.(1108-1110)Tct>Cct	p.S370P	ZFP57_ENST00000376881.3_Missense_Mutation_p.S370P|ZFP57_ENST00000488757.1_Missense_Mutation_p.S390P			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	306					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						AAAGTCAAAGAACAATGGGGG	0.517000													90	171					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3134559	3134559	+	Missense_Mutation	SNP	C	C	T	rs140979048	by1000genomes	TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr4:3134559C>T	ENST00000355072.5	+	18	2559	c.2414C>T	c.(2413-2415)gCg>gTg	p.A805V		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	805					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TTTTCTTTGGCGGATTGCATT	0.383000													69	88					0	0	1	0	0
PPP2R5C	5527	broad.mit.edu	37	14	102391492	102391492	+	Silent	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr14:102391492G>A	ENST00000422945.2	+	16	1647	c.1551G>A	c.(1549-1551)ccG>ccA	p.P517P	PPP2R5C_ENST00000350249.3_Silent_p.P447P|PPP2R5C_ENST00000334743.5_Silent_p.P486P|PPP2R5C_ENST00000328724.5_Silent_p.P502P	NM_001161725.1	NP_001155197.1	Q13362	2A5G_HUMAN	protein phosphatase 2, regulatory subunit B', gamma	486					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of cell proliferation|proteasomal ubiquitin-dependent protein catabolic process|signal transduction	chromosome, centromeric region|nucleus|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20						AGAAAGATCCGAAGAAGGACC	0.522000													32	135					0	0	1	0	0
IFNA17	3451	broad.mit.edu	37	9	21228107	21228107	+	Silent	SNP	T	T	C			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr9:21228107T>C	ENST00000413767.2	-	1	114	c.66A>G	c.(64-66)ctA>ctG	p.L22L		NM_021268.2	NP_067091.1	P01571	IFN17_HUMAN	interferon, alpha 17	22					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			breast(1)|endometrium(2)|lung(4)|ovary(1)|skin(1)	9				Lung(24;2.13e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		GATCACAGCCTAGAGAACAGA	0.502000													4	92					0	0	1	0	0
SGSM3	27352	broad.mit.edu	37	22	40803533	40803533	+	Silent	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr22:40803533C>T	ENST00000248929.9	+	13	1674	c.1485C>T	c.(1483-1485)gaC>gaT	p.D495D	SGSM3_ENST00000454798.2_Silent_p.D428D	NM_015705.4	NP_056520.2	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	495	SH3.				cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)	19						AGCGGCACGACGACGACGAGC	0.657000													3	30					0	0	1	0	0
FPR1	2357	broad.mit.edu	37	19	52249967	52249967	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr19:52249967C>T	ENST00000595042.1	-	3	422	c.281G>A	c.(280-282)gGc>gAc	p.G94D	FPR1_ENST00000304748.4_Missense_Mutation_p.G94D	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	94					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	CAGGAACCAGCCGAAAGGCCA	0.517000													21	33					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11323863	11323863	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr19:11323863C>T	ENST00000294618.7	-	35	4491	c.4480G>A	c.(4480-4482)Gag>Aag	p.E1494K	DOCK6_ENST00000319867.7_Missense_Mutation_p.E833K|CTC-510F12.2_ENST00000588634.1_RNA	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1494	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						TGGCCGATCTCGAAGTTCTGT	0.642000													8	29					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16893709	16893709	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:16893709T>C	ENST00000430580.2	-	25	3691	c.2804A>G	c.(2803-2805)gAg>gGg	p.E935G	NBPF1_ENST00000432949.1_3'UTR|NBPF1_ENST00000420031.2_3'UTR	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	935	NBPF 5.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		ACGCTGTTGCTCCAATATGTA	0.458000													28	2448					0	0	1	0	0
AC024560.3	0	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	G	C			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr3:197348739G>C	ENST00000418868.1	-	0	520					NR_003266.2																						TAATTTTCTAGCTGTGAAAGA	0.398000													4	86					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22846975	22846975	+	Silent	SNP	C	C	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr19:22846975C>A	ENST00000456783.2	+	4	748	c.504C>A	c.(502-504)ccC>ccA	p.P168P		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				GAGAGAAACCCTACAAATGTA	0.338000													4	12					0.014758	0.0151094	1	1	0
GRIA1	0	broad.mit.edu	37	5	152870478	152870478	+	Silent	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr5:152870478C>T	ENST00000285900.5	+	1	373	c.30C>T	c.(28-30)acC>acT	p.T10T	GRIA1_ENST00000518862.1_Intron|GRIA1_ENST00000518142.1_Silent_p.T10T|GRIA1_ENST00000340592.5_Silent_p.T10T	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	10					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TCTTCTGCACCGGTTTCCTAG	0.527000													4	280					0	0	1	0	0
METTL9	51108	broad.mit.edu	37	16	21629323	21629323	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr16:21629323C>T	ENST00000358154.3	+	3	752	c.494C>T	c.(493-495)cCt>cTt	p.P165L	METTL9_ENST00000396014.4_Missense_Mutation_p.P165L	NM_001077180.1|NM_016025.3	NP_001070648.1|NP_057109.3	Q9H1A3	METL9_HUMAN	methyltransferase like 9	165								p.P165H(1)		endometrium(1)|kidney(3)|large_intestine(1)|lung(1)|ovary(1)	7				GBM - Glioblastoma multiforme(48;0.0759)		ATCATGAGCCCTCATTTTGAA	0.368000													31	98					0	0	1	0	0
SATB2	23314	broad.mit.edu	37	2	200137089	200137089	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr2:200137089C>T	ENST00000443023.1	-	10	3335	c.1870G>A	c.(1870-1872)Gcg>Acg	p.A624T	SATB2_ENST00000457245.1_Missense_Mutation_p.A683T|SATB2_ENST00000260926.5_Missense_Mutation_p.A683T|SATB2_ENST00000417098.1_Missense_Mutation_p.A683T|SATB2_ENST00000428695.1_Missense_Mutation_p.A565T			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	683						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						ACGTCCACCGCGGAGCCCAGG	0.572000													23	66					0	0	1	0	0
CC2D2A	57545	broad.mit.edu	37	4	15564984	15564984	+	Silent	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr4:15564984G>A	ENST00000424120.1	+	24	3275	c.3021G>A	c.(3019-3021)ttG>ttA	p.L1007L	CC2D2A_ENST00000503292.1_Silent_p.L1007L|CC2D2A_ENST00000389652.5_Silent_p.L958L|CC2D2A_ENST00000413206.1_Silent_p.L1007L			Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A	1007					cell projection organization	cilium|microtubule basal body				NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|urinary_tract(2)	32						TTAGCATTTTGGGCCTAAGCC	0.488000													4	6					0	0	1	0	0
TAP1	6890	broad.mit.edu	37	6	32815728	32815728	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr6:32815728G>T	ENST00000354258.4	-	8	2049	c.1888C>A	c.(1888-1890)Ccc>Acc	p.P630T	TAP1_ENST00000425148.2_Missense_Mutation_p.P369T|PSMB9_ENST00000395330.1_Intron	NM_000593.5	NP_000584.2	Q03518	TAP1_HUMAN	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	630	ABC transporter.				antigen processing and presentation of endogenous peptide antigen via MHC class I|cytosol to ER transport|intracellular transport of viral proteins in host cell|positive regulation of T cell mediated cytotoxicity	cytosol|plasma membrane|TAP complex	ADP binding|ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(4)|prostate(1)|skin(1)	21						TCATATTGGGGAAGGGGCTTC	0.582000													22	68					7.41877e-09	7.78066e-09	1	1	0
KDM4B	23030	broad.mit.edu	37	19	5041160	5041160	+	Silent	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr19:5041160G>A	ENST00000159111.4	+	5	548	c.330G>A	c.(328-330)ccG>ccA	p.P110P	KDM4B_ENST00000536461.1_Silent_p.P110P|KDM4B_ENST00000381759.4_Silent_p.P110P	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	110					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						ACTGTACCCCGCGGCACCAGG	0.577000													28	92					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	23689453	23689453	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr12:23689453C>T	ENST00000546136.1	-	13	1885	c.1883G>A	c.(1882-1884)cGc>cAc	p.R628H	SOX5_ENST00000545921.1_Missense_Mutation_p.R631H|SOX5_ENST00000381381.2_Missense_Mutation_p.R520H|SOX5_ENST00000309359.1_Missense_Mutation_p.R628H|SOX5_ENST00000541536.1_Missense_Mutation_p.R520H|SOX5_ENST00000451604.2_Missense_Mutation_p.R641H|SOX5_ENST00000396007.2_Missense_Mutation_p.R255H|SOX5_ENST00000537393.1_Missense_Mutation_p.R606H			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	641					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						TTCACCAATGCGCAGCTTTTT	0.517000													14	36					0	0	1	0	0
RAB8B	51762	broad.mit.edu	37	15	63555769	63555769	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr15:63555769C>A	ENST00000321437.4	+	8	731	c.575C>A	c.(574-576)aCa>aAa	p.T192K	RAB8B_ENST00000448330.2_Missense_Mutation_p.T175K	NM_016530.2	NP_057614.1	Q92930	RAB8B_HUMAN	RAB8B, member RAS oncogene family	192					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			kidney(3)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9						GTGAAAATAACAGAAAACCGA	0.423000													4	48					0.000602214	0.000623981	1	1	0
OR52J3	119679	broad.mit.edu	37	11	5068207	5068207	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr11:5068207T>C	ENST00000380370.1	+	1	452	c.452T>C	c.(451-453)gTa>gCa	p.V151A		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	151					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V151A(1)		NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGTGCATTGTAATTCGTCCC	0.473000													9	38					0	0	1	0	0
CERK	64781	broad.mit.edu	37	22	47085927	47085927	+	Silent	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr22:47085927G>A	ENST00000216264.8	-	12	1615	c.1503C>T	c.(1501-1503)tgC>tgT	p.C501C	CERK_ENST00000541677.1_Silent_p.C303C	NM_022766.5	NP_073603.2	Q8TCT0	CERK1_HUMAN	ceramide kinase	501					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	20		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		CCTCCCCGTCGCAGTTCCAGG	0.647000													14	14					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76868015	76868015	+	Missense_Mutation	SNP	C	C	A	rs41298133	by1000genomes	TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr11:76868015C>A	ENST00000409709.3	+	7	972	c.700C>A	c.(700-702)Cag>Aag	p.Q234K	MYO7A_ENST00000458637.2_Missense_Mutation_p.Q234K|MYO7A_ENST00000409619.2_Missense_Mutation_p.Q223K|MYO7A_ENST00000409893.1_Missense_Mutation_p.Q234K	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	234	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GAAGATTGAGCAGTACCTGCT	0.597000													4	61					0.184627	0.186799	1	1	0
PRG4	10216	broad.mit.edu	37	1	186276296	186276296	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:186276296C>T	ENST00000445192.2	+	7	1490	c.1445C>T	c.(1444-1446)cCt>cTt	p.P482L	PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367486.3_Missense_Mutation_p.P439L|PRG4_ENST00000367485.4_Missense_Mutation_p.P389L|PRG4_ENST00000367483.4_Missense_Mutation_p.P441L	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	482	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CCCAAAGAGCCTGCACCCACT	0.647000													25	44					0	0	1	0	0
SHARPIN	81858	broad.mit.edu	37	8	145154289	145154289	+	Silent	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr8:145154289G>A	ENST00000398712.2	-	6	1249	c.813C>T	c.(811-813)gtC>gtT	p.V271V		NM_030974.3	NP_112236.3	Q9H0F6	SHRPN_HUMAN	SHANK-associated RH domain interactor	271	Interaction with SHANK1 (By similarity).|Ubiquitin-like.				negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(2)|ovary(2)	7	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCGTCCGATGACCCAGCGTT	0.632000													17	59					0	0	1	0	0
CACNG7	59284	broad.mit.edu	37	19	54445483	54445483	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr19:54445483C>T	ENST00000391767.1	+	6	976	c.764C>T	c.(763-765)aCg>aTg	p.T255M	CACNG7_ENST00000222212.2_Missense_Mutation_p.T255M			P62955	CCG7_HUMAN	calcium channel, voltage-dependent, gamma subunit 7	255				GAGVMSVYLFTKRYAEEEMYRPHPAFYRPRLSDCSDYSGQF LQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHIST SPC -> VTSVGPRL (in Ref. 1; AAK20030).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		ATCCAAATGACGCAGAACTAC	0.687000													19	162					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55418538	55418538	+	Missense_Mutation	SNP	T	T	G			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr11:55418538T>G	ENST00000312422.2	+	1	159	c.159T>G	c.(157-159)ttT>ttG	p.F53L		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				GCAACCTGTTTAAGTCACCCA	0.393000													4	85					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292770	102292770	+	RNA	SNP	C	C	T	rs149751844	by1000genomes	TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr15:102292770C>T	ENST00000561463.1	+	0	816																											AGCGGCGCGACGAGATGCTGC	0.597000													3	42					0	0	1	0	0
GOLGA2B	0	broad.mit.edu	37	12	100562731	100562731	+	RNA	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr12:100562731G>A	ENST00000397112.4	-	0	599					NR_036632.1															large_intestine(1)|lung(3)	4						GCCTGAGGGCGTCTCTCTCTT	0.542000													5	57					0	0	1	0	0
GJB5	2709	broad.mit.edu	37	1	35223665	35223665	+	Missense_Mutation	SNP	C	C	T	rs148092547		TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:35223665C>T	ENST00000338513.1	+	2	907	c.734C>T	c.(733-735)tCg>tTg	p.S245L		NM_005268.3	NP_005259.1	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	245					cell communication|epidermis development	connexon complex|integral to membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(1)	10		Myeloproliferative disorder(586;0.0393)				GACCTCCTTTCGGGTGACCTC	0.567000													16	45					0	0	1	0	0
SYT15	83849	broad.mit.edu	37	10	46967543	46967543	+	Silent	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr10:46967543C>T	ENST00000374323.3	-	3	1280	c.693G>A	c.(691-693)tcG>tcA	p.S231S	SYT15_ENST00000503753.1_Silent_p.S178S|SYT15_ENST00000374325.3_Silent_p.S178S|SYT15_ENST00000374321.4_Silent_p.S178S			Q9BQS2	SYT15_HUMAN	synaptotagmin XV	178	C2 1.					integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						TGCAGGTCTCCGAGGGGGCTT	0.627000													5	56					0	0	1	0	0
RUFY4	285180	broad.mit.edu	37	2	218940430	218940430	+	Silent	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr2:218940430G>A	ENST00000374155.3	+	8	1685	c.1275G>A	c.(1273-1275)gaG>gaA	p.E425E	RUFY4_ENST00000441828.2_3'UTR|RUFY4_ENST00000344321.7_Silent_p.E405E|RUFY4_ENST00000463872.1_3'UTR			Q6ZNE9	RUFY4_HUMAN	RUN and FYVE domain containing 4	405							metal ion binding			endometrium(2)|kidney(2)|large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(1)	10		Renal(207;0.0915)		Epithelial(149;4.11e-06)|all cancers(144;0.000519)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GAAGGGAGGAGCAAGCCGAGG	0.562000													10	69					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													4	43					0	0	1	0	0
PTPLA	9200	broad.mit.edu	37	10	17645744	17645744	+	Splice_Site	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr10:17645744C>T	ENST00000361271.3	-	3	413		c.e3-1			NM_014241.3	NP_055056.3	B0YJ81	HACD1_HUMAN	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A						fatty acid biosynthetic process|multicellular organismal development|signal transduction	endoplasmic reticulum membrane|integral to membrane	lyase activity|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|skin(1)	13						AGTGAACTATCTGTAAGCAAA	0.284000													6	50					0	0	1	0	0
ZNF502	91392	broad.mit.edu	37	3	44763153	44763153	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr3:44763153C>T	ENST00000296091.4	+	4	1100	c.844C>T	c.(844-846)Ctt>Ttt	p.L282F	ZNF502_ENST00000449836.1_Missense_Mutation_p.L282F|ZNF502_ENST00000436624.2_Missense_Mutation_p.L282F	NM_001134440.1|NM_033210.4	NP_001127912.1|NP_149987.2	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(8)|lung(4)|prostate(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		GAATACACACCTTATTCATCA	0.413000													29	179					0	0	1	0	0
CPT1C	126129	broad.mit.edu	37	19	50214009	50214009	+	Silent	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr19:50214009G>A	ENST00000392518.4	+	16	2133	c.1761G>A	c.(1759-1761)gaG>gaA	p.E587E	CPT1C_ENST00000323446.5_Silent_p.E587E|CPT1C_ENST00000598293.1_Silent_p.E587E|CPT1C_ENST00000354199.5_Silent_p.E587E|CPT1C_ENST00000405931.2_Silent_p.E576E	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	587					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TGACTTATGAGTCGGCCATGA	0.567000													18	47					0	0	1	0	0
CAMKK1	84254	broad.mit.edu	37	17	3786382	3786382	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr17:3786382G>A	ENST00000381771.2	-	6	749	c.602C>T	c.(601-603)gCc>gTc	p.A201V	CAMKK1_ENST00000158166.5_Missense_Mutation_p.A201V|CAMKK1_ENST00000381769.2_Missense_Mutation_p.A228V|CAMKK1_ENST00000348335.2_Missense_Mutation_p.A201V			Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase kinase 1, alpha	201	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	11				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		CTTCAGGATGGCAATCTCCTG	0.632000													3	47					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276272	186276272	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:186276272C>T	ENST00000445192.2	+	7	1466	c.1421C>T	c.(1420-1422)cCt>cTt	p.P474L	PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367486.3_Missense_Mutation_p.P431L|PRG4_ENST00000367485.4_Missense_Mutation_p.P381L|PRG4_ENST00000367483.4_Missense_Mutation_p.P433L	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	474	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						ACCAAGGAGCCTGCACCCACC	0.647000													14	46					0	0	1	0	0
RPS20	6224	broad.mit.edu	37	8	56986676	56986676	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr8:56986676C>T	ENST00000519807.1	-	2	171	c.46G>A	c.(46-48)Gca>Aca	p.A16T	RPS20_ENST00000009589.3_Missense_Mutation_p.A16T|RPS20_ENST00000520627.1_Intron|RPS20_ENST00000524349.1_5'UTR|RPS20_ENST00000520490.1_5'UTR|RPS20_ENST00000518875.1_Missense_Mutation_p.A16T|RPS20_ENST00000519606.1_Missense_Mutation_p.A16T|RPS20_ENST00000521262.1_Missense_Mutation_p.A16T|RPS20_ENST00000523936.1_Missense_Mutation_p.A16T	NM_001146227.1	NP_001139699.1	P60866	RS20_HUMAN	ribosomal protein S20	16					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome						all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.155)	Epithelial(17;0.00117)|all cancers(17;0.00879)			CGGTGAATTGCCACCTCCGGC	0.473000													4	135					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43821106	43821106	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr15:43821106C>T	ENST00000382031.1	+	5	8180	c.8149C>T	c.(8149-8151)Cgg>Tgg	p.R2717W	MAP1A_ENST00000300231.5_Missense_Mutation_p.R2479W|MAP1A_ENST00000399453.1_Missense_Mutation_p.R2479W			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2479						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity	p.R2479W(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	AAGAGGGGGGCGGCGCCGGGT	0.622000													18	43					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147744151	147744151	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chrX:147744151C>G	ENST00000370460.2	+	3	1382	c.903C>G	c.(901-903)atC>atG	p.I301M	AFF2_ENST00000342251.3_Missense_Mutation_p.I297M|AFF2_ENST00000370457.5_Missense_Mutation_p.I297M|AFF2_ENST00000370458.1_Missense_Mutation_p.I297M	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	301					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CACCGGACATCTCACCAACAC	0.483000													37	10					0	0	1	0	0
SIK3	23387	broad.mit.edu	37	11	116798051	116798051	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr11:116798051C>G	ENST00000375300.1	-	4	505	c.500G>C	c.(499-501)cGg>cCg	p.R167P	SIK3_ENST00000292055.4_Missense_Mutation_p.R109P|SIK3_ENST00000542607.1_Missense_Mutation_p.R109P|SIK3_ENST00000375288.1_5'UTR|SIK3_ENST00000434315.2_Missense_Mutation_p.R8P|SIK3_ENST00000446921.2_Missense_Mutation_p.R167P			Q9Y2K2	SIK3_HUMAN	SIK family kinase 3	109	Protein kinase.					cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	57						TTTGAACTTCCGACGTGCCTC	0.413000													31	56					0	0	1	0	0
INHA	3623	broad.mit.edu	37	2	220437228	220437228	+	Silent	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr2:220437228C>T	ENST00000243786.2	+	1	312	c.132C>T	c.(130-132)ccC>ccT	p.P44P	INHA_ENST00000489456.1_Intron	NM_002191.3	NP_002182.1	P05111	INHA_HUMAN	inhibin, alpha	44					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			large_intestine(2)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		TGGGGCCCCCCGCGGTGACCA	0.687000											OREG0003991	type=REGULATORY REGION|Gene=BC045558|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	3	4					0	0	1	0	0
RASL10A	10633	broad.mit.edu	37	22	29709922	29709922	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr22:29709922C>T	ENST00000401450.3	-	2	719	c.274G>A	c.(274-276)Gtc>Atc	p.V92I	RASL10A_ENST00000216101.6_Missense_Mutation_p.V92I|RASL10A_ENST00000474590.1_5'UTR			Q92737	RSLAA_HUMAN	RAS-like, family 10, member A	92	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			NS(1)	1						ATGTCGTAGACGAGCACGAAG	0.642000													10	24					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19468211	19468211	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:19468211G>A	ENST00000375267.2	-	56	8243	c.8240C>T	c.(8239-8241)cCg>cTg	p.P2747L	UBR4_ENST00000375254.3_Missense_Mutation_p.P2747L|UBR4_ENST00000375217.2_Missense_Mutation_p.P2775L|UBR4_ENST00000375226.2_Missense_Mutation_p.P2758L			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2747					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ACCACCATTCGGGATCCCTGA	0.512000													16	55					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235840908	235840908	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:235840908T>C	ENST00000389794.3	-	49	10986	c.10812A>G	c.(10810-10812)atA>atG	p.I3604M	LYST_ENST00000473037.1_5'UTR|LYST_ENST00000389793.2_Missense_Mutation_p.I3604M			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3604					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCTCCATTTCTATTTCTGATG	0.328000													22	50					0	0	1	0	0
SLX4IP	128710	broad.mit.edu	37	20	10603340	10603340	+	Silent	SNP	G	G	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr20:10603340G>A	ENST00000334534.5	+	8	720	c.540G>A	c.(538-540)acG>acA	p.T180T		NM_001009608.1	NP_001009608.1			SLX4 interacting protein																		GCAGTGTCACGAGCAAATCGC	0.433000													15	41					0	0	1	0	0
WASF2	10163	broad.mit.edu	37	1	27742572	27742573	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:27742572_27742573delTT	ENST00000430629.2	-	5	658_659	c.443_444delAA	c.(442-444)afs	p.K148fs	WASF2_ENST00000536657.1_Frame_Shift_Del_p.K148fs	NM_001201404.1|NM_006990.3	NP_001188333.1|NP_008921.1	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	148					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	18		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		CTGTGTAGAATTTGAGTGCCTC	0.441													18	92	---	---	---	---					
IRF6	3664	broad.mit.edu	37	1	209963883	209963890	+	Frame_Shift_Del	DEL	TCTCTCAA	TCTCTCAA	-	rs121434231		TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr1:209963883_209963890delTCTCTCAA	ENST00000367021.3	-	7	1182_1189	c.1010_1017delTTGAGAGA	c.(1009-1017)afs	p.IER337fs	IRF6_ENST00000542854.1_Frame_Shift_Del_p.IER242fs	NM_006147.3	NP_006138.1	O14896	IRF6_HUMAN	interferon regulatory factor 6	337					cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	28				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CCTTCTTTTGTCTCTCAATCAGGTTGGG	0.481										HNSCC(57;0.16)			14	52	---	---	---	---					
ANKAR	150709	broad.mit.edu	37	2	190541783	190541786	+	Frame_Shift_Del	DEL	AAAT	AAAT	-			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr2:190541783_190541786delAAAT	ENST00000520309.1	+	2	655_658	c.567_570delAAAT	c.(565-570)acfs	p.TN189fs	ANKAR_ENST00000313581.4_Frame_Shift_Del_p.TN189fs|ANKAR_ENST00000438402.2_Frame_Shift_Del_p.TN189fs|ANKAR_ENST00000281412.6_5'UTR|ANKAR_ENST00000431575.2_Frame_Shift_Del_p.TN118fs|ANKAR_ENST00000461516.1_Intron	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	189						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			AACCTCAAACAAATAAAGACATTT	0.348													19	35	---	---	---	---					
CCR3	1232	broad.mit.edu	37	3	46306948	46306948	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr3:46306948delT	ENST00000357422.2	+	4	842	c.299delT	c.(298-300)gtfs	p.V100fs	CCR3_ENST00000541018.1_Frame_Shift_Del_p.V100fs|CCR3_ENST00000395940.2_Frame_Shift_Del_p.V100fs|CCR3_ENST00000395942.2_Frame_Shift_Del_p.V100fs|CCR3_ENST00000545097.1_Frame_Shift_Del_p.V121fs			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	100					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CATAACTGGGTTTTTGGCCAT	0.488													7	202	---	---	---	---					
FAM86JP	0	broad.mit.edu	37	3	125642556	125642557	+	RNA	INS	-	-	C	rs112362688		TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr3:125642556_125642557insC	ENST00000485843.1	+	0	332					NR_024251.1																						ATCATCTCCCAGGCATCACAGG	0.579													8	13	---	---	---	---					
PIGG	54872	broad.mit.edu	37	4	494202	494203	+	Frame_Shift_Ins	INS	-	-	CCACGCTG			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr4:494202_494203insCCACGCTG	ENST00000453061.2	+	2	278_279	c.172_173insCCACGCTG	c.(172-174)cacfs	p.H58fs	PIGG_ENST00000536264.1_5'UTR|PIGG_ENST00000504346.1_5'UTR|PIGG_ENST00000509768.1_5'UTR|PIGG_ENST00000383028.4_Frame_Shift_Ins_p.H58fs|PIGG_ENST00000296306.7_5'UTR|PIGG_ENST00000310340.5_Frame_Shift_Ins_p.H58fs|PIGG_ENST00000503111.1_5'UTR|PIGG_ENST00000502311.1_3'UTR	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	58					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						TTCTAACTGGACCACGCTGCCA	0.401													11	77	---	---	---	---					
SMARCAD1	56916	broad.mit.edu	37	4	95200079	95200080	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr4:95200079_95200080insA	ENST00000457823.2	+	19	2577_2578	c.2302_2303insA	c.(2302-2304)aaafs	p.K768fs	SMARCAD1_ENST00000354268.4_Splice_Site|SMARCAD1_ENST00000509418.1_Splice_Site	NM_001128429.2|NM_020159.4	NP_001121901.1|NP_064544.2	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1	766					chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|liver(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TTGAGTCACAGAAAAAAACACA	0.317													17	33	---	---	---	---					
CCDC132	55610	broad.mit.edu	37	7	92970865	92970866	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr7:92970865_92970866delAG	ENST00000544910.1	+	24	2315_2316	c.2095_2096delAG	c.(2095-2097)afs	p.R699fs	CCDC132_ENST00000535481.1_Frame_Shift_Del_p.R449fs|CCDC132_ENST00000541136.1_Frame_Shift_Del_p.R540fs|CCDC132_ENST00000305866.5_Frame_Shift_Del_p.R729fs|CCDC132_ENST00000474412.1_3'UTR	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	729										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			GTTGGCAGAAAGAGTGGTAGCC	0.411													22	78	---	---	---	---					
KMT2C	58508	broad.mit.edu	37	7	151877140	151877140	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr7:151877140delC	ENST00000355193.2	-	37	7439	c.7221delG	c.(7219-7221)ggfs	p.G2407fs	KMT2C_ENST00000262189.6_Frame_Shift_Del_p.G2407fs					lysine (K)-specific methyltransferase 2C																		AGTCCTGTGACCCCTTCTCCT	0.522													57	230	---	---	---	---					
ZNF658	26149	broad.mit.edu	37	9	40789482	40789483	+	Splice_Site	INS	-	-	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr9:40789482_40789483insA	ENST00000602553.1	-	2	94		c.e2-2		ZNF658_ENST00000377626.3_Intron|ZNF658_ENST00000441795.1_Splice_Site			Q5TYW1	ZN658_HUMAN	zinc finger protein 658						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TTCATGTGCCTAAAAAAAAAAA	0.426													2	4	---	---	---	---					
CDK12	51755	broad.mit.edu	37	17	37627854	37627855	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr17:37627854_37627855insA	ENST00000447079.4	+	2	1802_1803	c.1769_1770insA	c.(1768-1770)taafs	p.*590fs	CDK12_ENST00000430627.2_Frame_Shift_Ins_p.*590fs	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	590					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						TCTACTCACTCAAAGACATCTG	0.485			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			58	120	---	---	---	---					
KDM4B	23030	broad.mit.edu	37	19	5040011	5040012	+	Frame_Shift_Ins	INS	-	-	A			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr19:5040011_5040012insA	ENST00000159111.4	+	4	524_525	c.306_307insA	c.(304-309)gcacagfs	p.Q103fs	KDM4B_ENST00000381759.4_Frame_Shift_Ins_p.Q103fs|KDM4B_ENST00000536461.1_Frame_Shift_Ins_p.Q103fs	NM_015015.2	NP_055830.1	O94953	KDM4B_HUMAN	lysine (K)-specific demethylase 4B	103					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(1)|liver(1)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						GCCGCCTGGCCAACAGCGAGAA	0.693													13	38	---	---	---	---					
CLASRP	11129	broad.mit.edu	37	19	45567607	45567609	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chr19:45567607_45567609delCTC	ENST00000544944.2	+	12	1820_1822	c.1128_1130delCTC	c.(1126-1131)cgc>cg	p.RS376del	CLASRP_ENST00000391953.4_In_Frame_Del_p.RS314del|CLASRP_ENST00000221455.3_In_Frame_Del_p.RS376del			Q8N2M8	CLASR_HUMAN	CLK4-associating serine/arginine rich protein	376	Arg-rich.				mRNA processing|RNA splicing	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|pancreas(2)|prostate(1)	16						GCAGCCGCCGctcctcctcctcc	0.744													2	4	---	---	---	---					
SHROOM4	57477	broad.mit.edu	37	X	50345633	50345634	+	Splice_Site	INS	-	-	T			TCGA-ZG-A9KY-01A-11D-A41K-08	TCGA-ZG-A9KY-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4aeba7a2-387f-41b0-ba7d-24d6c0c96b22	caacdc42-537a-470f-b215-c0727d083e42	g.chrX:50345633_50345634insT	ENST00000376020.2	-	7	3966_3967	c.3942_splice	c.e7+1	p.N1314_splice	SHROOM4_ENST00000460112.3_Splice_Site_p.N1198_splice|SHROOM4_ENST00000289292.7_Splice_Site_p.N1314_splice	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1314	ASD2.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding	p.K1314fs*23(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					AAAACTTTACCTTTTTTTGAGC	0.450													32	23	---	---	---	---