Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C17orf80	55028	broad.mit.edu	37	17	71232151	71232151	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr17:71232151C>T	ENST00000359042.2	+	3	724	c.530C>T	c.(529-531)tCa>tTa	p.S177L	FAM104A_ENST00000583178.1_Intron|C17orf80_ENST00000268942.8_Missense_Mutation_p.S177L|C17orf80_ENST00000577615.1_Missense_Mutation_p.S177L|C17orf80_ENST00000582793.1_Intron|C17orf80_ENST00000426147.2_Missense_Mutation_p.S177L|C17orf80_ENST00000535032.2_Missense_Mutation_p.S177L|C17orf80_ENST00000255557.4_Missense_Mutation_p.S177L	NM_017941.4	NP_060411.2	Q9BSJ5	CQ080_HUMAN	chromosome 17 open reading frame 80	177						integral to membrane				kidney(1)|large_intestine(5)|lung(2)|skin(2)|stomach(2)|urinary_tract(2)	14			LUSC - Lung squamous cell carcinoma(166;0.197)			CTGGTTGGCTCAATAGAACCT	0.378000													11	59					0	0	1	0	0
RP11-467H10.2	0	broad.mit.edu	37	7	76681226	76681226	+	RNA	SNP	G	G	C			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr7:76681226G>C	ENST00000459742.1	+	0	58																											TGTCACACTTGAAGGAGGCAG	0.453000													2	5					0	0	1	0	0
GPR115	221393	broad.mit.edu	37	6	47682675	47682675	+	Missense_Mutation	SNP	C	C	T	rs140641930	byFrequency	TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr6:47682675C>T	ENST00000283303.2	+	6	1952	c.1694C>T	c.(1693-1695)cCg>cTg	p.P565L	GPR115_ENST00000327753.3_Missense_Mutation_p.P565L|GPR115_ENST00000371220.1_Missense_Mutation_p.P622L	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	565					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						TTTGCCATCCCGGCGTTCGTC	0.488000													38	76					0	0	1	0	0
ZNF57	126295	broad.mit.edu	37	19	2917857	2917857	+	Missense_Mutation	SNP	C	C	T	rs148390269		TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr19:2917857C>T	ENST00000306908.5	+	4	1386	c.1238C>T	c.(1237-1239)aCg>aTg	p.T413M	ZNF57_ENST00000523428.1_Missense_Mutation_p.T381M|AC006277.2_ENST00000520090.2_RNA	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		CATTTGAGGACGCACACTGGA	0.438000													5	79					0	0	1	0	0
R3HDML	140902	broad.mit.edu	37	20	42972025	42972025	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr20:42972025C>A	ENST00000217043.2	+	3	561	c.389C>A	c.(388-390)tCc>tAc	p.S130Y		NM_178491.2	NP_848586.1	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like	130						extracellular region	peptidase inhibitor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)	21		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			AGGTACCGGTCCGTAGTGGAT	0.597000													4	42					1	1	1	1	0
PCDHB15	0	broad.mit.edu	37	5	140625165	140625165	+	Missense_Mutation	SNP	C	C	T	rs147410183		TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr5:140625165C>T	ENST00000231173.3	+	1	19	c.19C>T	c.(19-21)Cgc>Tgc	p.R7C		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		7					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCAGGGGAGCGCTTTCCCGA	0.537000													12	21					0	0	1	0	0
MST1	4485	broad.mit.edu	37	3	49721883	49721883	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr3:49721883G>T	ENST00000449682.2	-	17	2241	c.1880C>A	c.(1879-1881)aCg>aAg	p.T627K		NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	613	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GTCATTACCCGTACCTGCAGT	0.577000													5	77					0.014758	0.0158718	1	1	0
IFT52	51098	broad.mit.edu	37	20	42242496	42242496	+	Silent	SNP	C	C	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr20:42242496C>A	ENST00000373030.3	+	7	622	c.492C>A	c.(490-492)ctC>ctA	p.L164L	IFT52_ENST00000373039.4_Silent_p.L164L	NM_016004.2	NP_057088.2	Q9Y366	IFT52_HUMAN	intraflagellar transport 52 homolog (Chlamydomonas)	164						intraflagellar transport particle B|microtubule-based flagellum	protein C-terminus binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			ACAGGGCTCTCACCTTTGTGT	0.363000													9	71					1.76689e-08	2.14283e-08	1	1	0
DNMT3B	1789	broad.mit.edu	37	20	31386422	31386422	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr20:31386422C>A	ENST00000328111.2	+	15	1968	c.1647C>A	c.(1645-1647)ttC>ttA	p.F549L	DNMT3B_ENST00000456297.2_Missense_Mutation_p.F453L|DNMT3B_ENST00000353855.2_Missense_Mutation_p.F529L|DNMT3B_ENST00000348286.2_Missense_Mutation_p.F529L|DNMT3B_ENST00000201963.3_Missense_Mutation_p.F541L|DNMT3B_ENST00000375623.4_3'UTR|DNMT3B_ENST00000443239.3_Missense_Mutation_p.F487L|DNMT3B_ENST00000344505.4_Missense_Mutation_p.F529L	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	549	ADD.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TGCAGGCCTTCTTCACCAGTG	0.607000													6	36					0.217242	0.225142	1	1	0
SERPINA3	12	broad.mit.edu	37	14	95081101	95081101	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr14:95081101C>T	ENST00000553947.1	+	5	1286	c.398C>T	c.(397-399)aCg>aTg	p.T133M	SERPINA3_ENST00000393078.3_Missense_Mutation_p.T108M|SERPINA3_ENST00000556388.1_Intron|SERPINA3_ENST00000467132.1_Missense_Mutation_p.T108M|SERPINA3_ENST00000393080.4_Missense_Mutation_p.T108M			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	108					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity	p.T108M(1)		NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		TTCAACCTCACGGAGACTTCT	0.552000													28	32					0	0	1	0	0
FBXO45	200933	broad.mit.edu	37	3	196311181	196311181	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr3:196311181G>T	ENST00000311630.6	+	3	1150	c.853G>T	c.(853-855)Gac>Tac	p.D285Y	FBXO45_ENST00000440469.1_Missense_Mutation_p.D106Y	NM_001105573.1	NP_001099043.1	P0C2W1	FBSP1_HUMAN	F-box protein 45	285					nervous system development|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	cell junction|postsynaptic membrane|presynaptic membrane	protein binding			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	7	all_cancers(143;8.88e-09)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;2.75e-23)|all cancers(36;2.47e-21)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00314)		AAAACCTTTGGACGGATGACA	0.448000													12	24					1.61879e-10	2.00589e-10	1	1	0
C3orf17	25871	broad.mit.edu	37	3	112732171	112732171	+	Nonsense_Mutation	SNP	C	C	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr3:112732171C>A	ENST00000314400.5	-	4	612	c.421G>T	c.(421-423)Gga>Tga	p.G141*	C3orf17_ENST00000393857.2_Nonsense_Mutation_p.G5*|C3orf17_ENST00000383675.2_Intron	NM_015412.3	NP_056227.2	Q6NW34	CC017_HUMAN	chromosome 3 open reading frame 17	141						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(2)|lung(6)|prostate(2)|skin(1)	13						TTGCAGGCTCCCAAAACCTTC	0.398000													4	71					0.000602214	0.000673063	1	1	0
ZNF117	51351	broad.mit.edu	37	7	64438887	64438887	+	Silent	SNP	A	A	G			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr7:64438887A>G	ENST00000282869.5	-	4	2346	c.1062T>C	c.(1060-1062)atT>atC	p.I354I		NM_015852.3	NP_056936.2	Q03924	ZN117_HUMAN	zinc finger protein 117	354						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(1)|skin(1)	22		Lung NSC(55;0.0295)|all_lung(88;0.0691)				CTCCAGTATGAATTACCTTAT	0.388000													7	106					0	0	1	0	0
MTMR14	64419	broad.mit.edu	37	3	9712766	9712766	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr3:9712766G>A	ENST00000296003.4	+	6	711	c.589G>A	c.(589-591)Ggc>Agc	p.G197S	MTMR14_ENST00000420925.1_Intron|MTMR14_ENST00000353332.5_Missense_Mutation_p.G197S|MTMR14_ENST00000351233.5_Missense_Mutation_p.G197S	NM_001077525.2	NP_001070993.1	Q8NCE2	MTMRE_HUMAN	myotubularin related protein 14	197						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(2)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	21	Medulloblastoma(99;0.227)					TAAGGTCAGAGGCTATGACAT	0.468000													4	104					0	0	1	0	0
ZFP36	7538	broad.mit.edu	37	19	39899003	39899003	+	Silent	SNP	C	C	G	rs149138506		TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr19:39899003C>G	ENST00000597629.1	+	2	737	c.663C>G	c.(661-663)ccC>ccG	p.P221P	ZFP36_ENST00000248673.3_Silent_p.P215P			P26651	TTP_HUMAN	ZFP36 ring finger protein	215					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			large_intestine(1)|lung(5)|pancreas(1)	7	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCTTCTCGCCCTCCAGCTCCC	0.692000													42	72					0	0	1	0	0
CCNK	8812	broad.mit.edu	37	14	99969193	99969193	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr14:99969193C>G	ENST00000389879.5	+	8	1006	c.883C>G	c.(883-885)Caa>Gaa	p.Q295E	CCNK_ENST00000555049.1_Missense_Mutation_p.Q295E	NM_001099402.1	NP_001092872.1	O75909	CCNK_HUMAN	cyclin K	295					cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding			NS(1)|endometrium(2)|lung(3)	6		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)				ACAGCCGTCTCAAAGCTCCGA	0.602000													14	37					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57187780	57187780	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr7:57187780A>C	ENST00000331162.4	-	5	1612	c.1342T>G	c.(1342-1344)Tta>Gta	p.L448V		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	448					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			GTTGAGGATAAGCTAAAGGCT	0.438000													5	154					0	0	1	0	0
MYH9	4627	broad.mit.edu	37	22	36715609	36715609	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr22:36715609G>A	ENST00000216181.5	-	10	1314	c.1084C>T	c.(1084-1086)Cag>Tag	p.Q362*		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	362	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						ATGGACGCCTGGTCAGTGTTC	0.577000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				8	22					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7574003	7574003	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr17:7574003G>A	ENST00000269305.4	-	10	1213	c.1024C>T	c.(1024-1026)Cga>Tga	p.R342*	TP53_ENST00000420246.2_3'UTR|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Nonsense_Mutation_p.R342*|TP53_ENST00000359597.4_Intron|TP53_ENST00000455263.2_3'UTR	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	342	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		R -> L (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R342*(70)|p.0?(8)|p.R342fs*3(8)|p.?(1)|p.R342_N345delRELN(1)|p.I332fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCAGCTCTCGGAACATCTCG	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	10					0	0	1	0	0
RAI14	26064	broad.mit.edu	37	5	34796092	34796092	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr5:34796092G>T	ENST00000265109.3	+	4	503	c.216G>T	c.(214-216)atG>atT	p.M72I	RAI14_ENST00000428746.2_Missense_Mutation_p.M72I|RAI14_ENST00000503673.1_Missense_Mutation_p.M72I|RAI14_ENST00000512629.1_Missense_Mutation_p.M72I|RAI14_ENST00000507276.1_3'UTR|RAI14_ENST00000506376.1_Missense_Mutation_p.M64I|RAI14_ENST00000397449.1_Missense_Mutation_p.M65I|RAI14_ENST00000515799.1_Missense_Mutation_p.M75I	NM_001145522.1|NM_015577.2	NP_001138994.1|NP_056392.2	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14	72						cell cortex|cytoskeleton	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(19)|lung(22)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(31;0.000191)					TCAGGGTCATGATTACACATG	0.428000													5	116					2.0095e-06	2.29083e-06	1	1	0
OR2M4	26245	broad.mit.edu	37	1	248402787	248402787	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr1:248402787C>A	ENST00000306687.1	+	1	557	c.557C>A	c.(556-558)cCt>cAt	p.P186H		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCCCTTTTACCTCTATCCTGC	0.398000													13	122					1.3612e-06	1.58344e-06	1	1	0
NARFL	64428	broad.mit.edu	37	16	784748	784748	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr16:784748G>C	ENST00000540986.1	-	4	1692	c.257C>G	c.(256-258)tCt>tGt	p.S86C	NARFL_ENST00000301694.5_Missense_Mutation_p.L144V|NARFL_ENST00000251588.2_Missense_Mutation_p.S188C|NARFL_ENST00000568545.1_Missense_Mutation_p.S86C|HAGHL_ENST00000569604.1_3'UTR			Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	188					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				TGGGCAGGCAGAGGCCAGCAG	0.607000													42	50					0	0	1	0	0
ZNF800	168850	broad.mit.edu	37	7	127013781	127013781	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr7:127013781G>A	ENST00000393313.1	-	5	2200	c.1609C>T	c.(1609-1611)Cat>Tat	p.H537Y	ZNF800_ENST00000393312.1_Missense_Mutation_p.H537Y|ZNF800_ENST00000265827.3_Missense_Mutation_p.H537Y			Q2TB10	ZN800_HUMAN	zinc finger protein 800	537					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						ACAGTTATATGTCGTATCACA	0.348000													47	56					0	0	1	0	0
ZNF695	57116	broad.mit.edu	37	1	247150485	247150485	+	Silent	SNP	A	A	C			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr1:247150485A>C	ENST00000339986.7	-	4	1479	c.1332T>G	c.(1330-1332)gcT>gcG	p.A444A	ZNF695_ENST00000498046.2_Intron|ZNF695_ENST00000487338.2_Intron	NM_020394.4	NP_065127.4	Q8IW36	ZN695_HUMAN	zinc finger protein 695	444					regulation of transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	13	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			ACCAGTTAAAAGCTTTGCCAC	0.383000													17	35					0	0	1	0	0
RMI1	80010	broad.mit.edu	37	9	86615978	86615978	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr9:86615978G>C	ENST00000325875.3	+	3	409	c.77G>C	c.(76-78)tGg>tCg	p.W26S		NM_024945.2	NP_079221.2	Q9H9A7	RMI1_HUMAN	RecQ mediated genome instability 1	26					DNA replication	nucleus				biliary_tract(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						CCTCCGATGTGGCTGGAAGCT	0.348000													4	105					0	0	1	0	0
PPP1R12A	4659	broad.mit.edu	37	12	80182523	80182523	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr12:80182523A>C	ENST00000450142.2	-	21	2973	c.2707T>G	c.(2707-2709)Tcc>Gcc	p.S903A	PPP1R12A_ENST00000546369.1_Missense_Mutation_p.S816A|PPP1R12A_ENST00000261207.5_Missense_Mutation_p.S903A|PPP1R12A_ENST00000550107.1_Missense_Mutation_p.S847A|PPP1R12A_ENST00000437004.2_Missense_Mutation_p.S903A	NM_002480.2	NP_002471.1	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory subunit 12A	903						contractile fiber	protein binding|signal transducer activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|liver(1)|lung(4)|ovary(2)|skin(1)	29						CCCAGCAAGGAATCATATCGA	0.343000													12	20					0	0	1	0	0
ITM2A	9452	broad.mit.edu	37	X	78619050	78619050	+	Splice_Site	SNP	T	T	C			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chrX:78619050T>C	ENST00000373298.2	-	2	256	c.111_splice	c.e2-1	p.E38_splice	ITM2A_ENST00000469541.1_5'UTR|ITM2A_ENST00000434584.2_Intron	NM_004867.4	NP_004858.1	O43736	ITM2A_HUMAN	integral membrane protein 2A	38						integral to membrane	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	18						AACTCGGAGCTCCTATTTATT	0.398000													20	10					0	0	1	0	0
SLC4A3	6508	broad.mit.edu	37	2	220504357	220504357	+	Silent	SNP	G	G	A	rs138004203		TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr2:220504357G>A	ENST00000358055.3	+	20	3689	c.3177G>A	c.(3175-3177)gcG>gcA	p.A1059A	SLC4A3_ENST00000373760.2_Silent_p.A1059A|SLC4A3_ENST00000317151.3_Silent_p.A1059A|SLC4A3_ENST00000273063.6_Silent_p.A1086A|SLC4A3_ENST00000373762.3_Silent_p.A1086A			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	1059	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity	p.A1086A(1)		breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATGTCAATGCGTTGACAGTGA	0.652000													12	43					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21188821	21188821	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr1:21188821C>T	ENST00000602326.1	-	21	3444	c.2861G>A	c.(2860-2862)cGt>cAt	p.R954H	EIF4G3_ENST00000400422.1_Missense_Mutation_p.R948H|EIF4G3_ENST00000536266.1_Missense_Mutation_p.R552H|EIF4G3_ENST00000374935.3_Missense_Mutation_p.R668H|EIF4G3_ENST00000374937.3_Missense_Mutation_p.R954H|EIF4G3_ENST00000264211.8_Missense_Mutation_p.R948H|EIF4G3_ENST00000537738.1_Missense_Mutation_p.R438H	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	948	MIF4G.|eIF3/EIF4A-binding (By similarity).				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CTGGTCCATACGTGGCTGCAA	0.328000													16	47					0	0	1	0	0
BRAT1	221927	broad.mit.edu	37	7	2582851	2582851	+	Missense_Mutation	SNP	T	T	G			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr7:2582851T>G	ENST00000340611.4	-	6	1166	c.910A>C	c.(910-912)Aag>Cag	p.K304Q		NM_152743.3	NP_689956.2	Q6PJG6	BRAT1_HUMAN	BRCA1-associated ATM activator 1	304					response to ionizing radiation	nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23						TGCTCGAGCTTCAGGATCCCC	0.652000													14	47					0	0	1	0	0
SLC6A10P	0	broad.mit.edu	37	16	32890622	32890622	+	RNA	SNP	T	T	G			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr16:32890622T>G	ENST00000330048.5	-	0	3176					NR_003083.2																						CGTTGGTGTTTTTGTAGACCA	0.617000													3	31					0	0	1	0	0
ZNRD1-AS1	0	broad.mit.edu	37	6	29977377	29977377	+	RNA	SNP	C	C	G			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr6:29977377C>G	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|HLA-J_ENST00000462773.1_RNA																							TTTGTGACTTCAAGAACCCTG	0.458000													3	38					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65083153	65083153	+	Silent	SNP	G	G	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr17:65083153G>A	ENST00000358691.5	-	32	5452	c.5286C>T	c.(5284-5286)atC>atT	p.I1762I	HELZ_ENST00000580168.1_Silent_p.I1763I	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGCTAGATGAGATTCTTCTTT	0.443000													8	35					0	0	1	0	0
CYP2C18	1562	broad.mit.edu	37	10	96448025	96448025	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr10:96448025A>C	ENST00000285979.6	+	3	674	c.475A>C	c.(475-477)Acc>Ccc	p.T159P	CYP2C18_ENST00000339022.5_Missense_Mutation_p.T159P|CYP2C19_ENST00000464755.1_3'UTR	NM_000772.2	NP_000763.1			cytochrome P450, family 2, subfamily C, polypeptide 18									p.T159P(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	26		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		GTTGAGAAAAACCAATGGTGG	0.383000													44	49					0	0	1	0	0
R3HDML	140902	broad.mit.edu	37	20	42972036	42972036	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr20:42972036C>A	ENST00000217043.2	+	3	572	c.400C>A	c.(400-402)Ctc>Atc	p.L134I		NM_178491.2	NP_848586.1	Q9H3Y0	CRSPL_HUMAN	R3H domain containing-like	134						extracellular region	peptidase inhibitor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)	21		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CGTAGTGGATCTCATGAAGTC	0.617000													6	46					0.27861	0.283586	1	1	0
ZNF57	126295	broad.mit.edu	37	19	2917842	2917842	+	Missense_Mutation	SNP	G	G	A	rs149690257	byFrequency	TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr19:2917842G>A	ENST00000306908.5	+	4	1371	c.1223G>A	c.(1222-1224)cGa>cAa	p.R408Q	ZNF57_ENST00000523428.1_Missense_Mutation_p.R376Q|AC006277.2_ENST00000520090.2_RNA	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	408					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		AGATCATTCCGAGGTCATTTG	0.428000													4	82					0	0	1	0	0
ZMYM3	9203	broad.mit.edu	37	X	70461117	70461117	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chrX:70461117G>A	ENST00000373998.1	-	24	4541	c.3844C>T	c.(3844-3846)Cgc>Tgc	p.R1282C	ZMYM3_ENST00000353904.2_Missense_Mutation_p.R1294C|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373984.3_Missense_Mutation_p.R1204C|ZMYM3_ENST00000314425.5_Missense_Mutation_p.R1294C|ZMYM3_ENST00000373988.1_Missense_Mutation_p.R1296C	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	1294					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					ACAGGGCAGCGGAGGGGATTC	0.507000													13	8					0	0	1	0	0
C1orf53	388722	broad.mit.edu	37	1	197876315	197876315	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr1:197876315A>C	ENST00000367393.3	+	3	406	c.403A>C	c.(403-405)Aaa>Caa	p.K135Q	C1orf53_ENST00000542800.1_3'UTR	NM_001024594.2	NP_001019765.1	Q5VUE5	CA053_HUMAN	chromosome 1 open reading frame 53	135										endometrium(1)|lung(1)	2						AGATCCATCTAAAAAGAAGCA	0.274000													13	19					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116919908	116919908	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr10:116919908C>T	ENST00000355044.3	+	6	1063	c.937C>T	c.(937-939)Cac>Tac	p.H313Y	ATRNL1_ENST00000529665.1_3'UTR|ATRNL1_ENST00000527407.1_Missense_Mutation_p.H313Y	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	313						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		AGCAGTTTTACACGGGAAATT	0.368000													19	97					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73240153	73240153	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr9:73240153C>T	ENST00000377110.2	-	13	1970	c.1727G>A	c.(1726-1728)cGc>cAc	p.R576H	TRPM3_ENST00000377105.1_Missense_Mutation_p.R435H|TRPM3_ENST00000360823.2_Missense_Mutation_p.R448H|TRPM3_ENST00000396292.4_Missense_Mutation_p.R448H|TRPM3_ENST00000357533.2_Missense_Mutation_p.R590H|TRPM3_ENST00000377111.2_Missense_Mutation_p.R576H|TRPM3_ENST00000396285.1_Missense_Mutation_p.R423H|TRPM3_ENST00000423814.3_Missense_Mutation_p.R603H|TRPM3_ENST00000377106.1_Missense_Mutation_p.R448H|TRPM3_ENST00000358082.3_Missense_Mutation_p.R448H|TRPM3_ENST00000408909.2_Missense_Mutation_p.R435H|TRPM3_ENST00000396280.5_Missense_Mutation_p.R435H	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	601						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GAAGCGCTTGCGCGTGTAGTT	0.597000													9	15					0	0	1	0	0
PRDX1	5052	broad.mit.edu	37	1	45980652	45980652	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr1:45980652C>G	ENST00000262746.1	-	4	615	c.276G>C	c.(274-276)aaG>aaC	p.K92N	PRDX1_ENST00000372079.1_Intron|PRDX1_ENST00000319248.8_Missense_Mutation_p.K92N	NM_002574.3|NM_181696.2	NP_002565.1|NP_859047.1	Q06830	PRDX1_HUMAN	peroxiredoxin 1	92	Thioredoxin.				cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	12	Acute lymphoblastic leukemia(166;0.155)					CTCCTTGTTTCTTAGGTGTAT	0.448000													53	108					0	0	1	0	0
TMEM106A	113277	broad.mit.edu	37	17	41367895	41367895	+	Missense_Mutation	SNP	C	C	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr17:41367895C>A	ENST00000331615.3	+	5	601	c.364C>A	c.(364-366)Cag>Aag	p.Q122K	TMEM106A_ENST00000588659.1_Missense_Mutation_p.Q122K|TMEM106A_ENST00000592564.1_3'UTR|TMEM106A_ENST00000541594.1_Missense_Mutation_p.Q74K|TMEM106A_ENST00000536052.1_Missense_Mutation_p.Q122K	NM_145041.1	NP_659478.1	Q96A25	T106A_HUMAN	transmembrane protein 106A	122						integral to membrane				NS(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11		Breast(137;0.0164)		BRCA - Breast invasive adenocarcinoma(366;0.0917)		CGTCATTGTGCAGCCTGCAGG	0.567000													41	158					8.16277e-20	1.03395e-19	1	1	0
IGHV4OR15-8	0	broad.mit.edu	37	15	22473098	22473098	+	RNA	SNP	C	C	T			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr15:22473098C>T	ENST00000557788.2	-	0	172																											TGGGGGCTGGCGGACCCAGCT	0.592000													14	107					0	0	1	0	0
ZNF578	147660	broad.mit.edu	37	19	53014268	53014268	+	Missense_Mutation	SNP	T	T	G			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr19:53014268T>G	ENST00000421239.2	+	6	878	c.634T>G	c.(634-636)Ttt>Gtt	p.F212V		NM_001099694.1	NP_001093164.1	Q96N58	ZN578_HUMAN	zinc finger protein 578	127					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding								GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		TGGGAATAATTTTTTCCATTC	0.363000													27	45					0	0	1	0	0
GRIA4	0	broad.mit.edu	37	11	105789611	105789611	+	Silent	SNP	C	C	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr11:105789611C>A	ENST00000393127.2	+	11	1889	c.1443C>A	c.(1441-1443)atC>atA	p.I481I	GRIA4_ENST00000530497.1_Silent_p.I481I|GRIA4_ENST00000525187.1_Silent_p.I481I|GRIA4_ENST00000282499.5_Silent_p.I481I	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	481					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	ACACAAAAATCTGGAATGGGA	0.368000													6	33					0.00307968	0.0033758	1	1	0
HNRNPDL	9987	broad.mit.edu	37	4	83350461	83350461	+	Missense_Mutation	SNP	T	T	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr4:83350461T>A	ENST00000295470.5	-	1	558	c.383A>T	c.(382-384)aAt>aTt	p.N128I	HNRNPDL_ENST00000514511.1_5'UTR|HNRNPDL_ENST00000502762.1_Missense_Mutation_p.N128I|HNRNPDL_ENST00000602300.1_Missense_Mutation_p.N9I|HNRNPDL_ENST00000349655.4_Missense_Mutation_p.N9I	NM_001207000.1|NM_031372.3	NP_001193929.1|NP_112740.1			heterogeneous nuclear ribonucleoprotein D-like																		TTCCTCTATATTGCTGTACTC	0.627000													59	59					0	0	1	0	0
SOX6	55553	broad.mit.edu	37	11	16007827	16007827	+	Silent	SNP	G	G	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr11:16007827G>A	ENST00000352083.6	-	15	2183	c.2106C>T	c.(2104-2106)ggC>ggT	p.G702G	SOX6_ENST00000527619.1_Silent_p.G678G|SOX6_ENST00000316399.6_Silent_p.G682G|SOX6_ENST00000528429.1_Silent_p.G702G|SOX6_ENST00000396356.3_Silent_p.G682G|SOX6_ENST00000528252.1_Silent_p.G675G			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	702					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						GAAGCTTTTTGCCATCAACAA	0.458000													49	116					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167095398	167095400	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr1:167095398_167095400delGAG	ENST00000361200.2	+	6	1196_1198	c.1030_1032delGAG	c.(1030-1032)del	p.E348del	DUSP27_ENST00000443333.1_In_Frame_Del_p.E348del|DUSP27_ENST00000485151.1_3'UTR|DUSP27_ENST00000271385.5_In_Frame_Del_p.E348del			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	348					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCTCATAGACGAGGAGGAGGAGG	0.655													2	4	---	---	---	---					
SOX14	8403	broad.mit.edu	37	3	137484144	137484149	+	In_Frame_Del	DEL	AGAACG	AGAACG	-			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr3:137484144_137484149delAGAACG	ENST00000306087.1	+	1	566_571	c.518_523delAGAACG	c.(517-525)cgc>c	p.QNG173del		NM_004189.3	NP_004180.1	O95416	SOX14_HUMAN	SRY (sex determining region Y)-box 14	173					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding			large_intestine(2)|lung(12)	14						CTGGGCTACCAGAACGGCGCCTTCGG	0.675													3	3	---	---	---	---					
KIF25	0	broad.mit.edu	37	6	168442674	168442674	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr6:168442674delC	ENST00000443060.2	+	8	1063	c.672delC	c.(670-672)ctfs	p.L224fs	KIF25_ENST00000354419.2_Frame_Shift_Del_p.L224fs|KIF25_ENST00000351261.3_Frame_Shift_Del_p.L224fs			Q9UIL4	KIF25_HUMAN	kinesin family member 25	224	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GTGCCACCCTCCCCAGGGAGC	0.612													2	4	---	---	---	---					
CCT6P3	0	broad.mit.edu	37	7	64532708	64532709	+	RNA	INS	-	-	A			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr7:64532708_64532709insA	ENST00000426828.1	+	0	1228					NR_033416.1																						AAATGGGGACCAAAAAAAAAAA	0.351													2	4	---	---	---	---					
CHRNA6	8973	broad.mit.edu	37	8	42611170	42611171	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr8:42611170_42611171delTG	ENST00000276410.2	-	5	1526_1527	c.1171_1172delCA	c.(1171-1173)tfs	p.H391fs	CHRNA6_ENST00000534622.1_Frame_Shift_Del_p.H376fs	NM_004198.3	NP_004189.1	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6 (neuronal)	391						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(2)|large_intestine(3)|liver(1)|lung(15)|ovary(1)	22	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			TTCTTTAAGATGTCTGGGTTCC	0.515													36	69	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49434024	49434024	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr12:49434024delA	ENST00000301067.7	-	31	7528	c.7529delT	c.(7528-7530)gcfs	p.V2510fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CCCACTTGGGACCTTGGCATG	0.652													10	19	---	---	---	---					
VASN	114990	broad.mit.edu	37	16	4432596	4432597	+	Frame_Shift_Ins	INS	-	-	C	rs76495149		TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chr16:4432596_4432597insC	ENST00000304735.3	+	2	1873_1874	c.1718_1719insC	c.(1717-1719)actfs	p.T573fs	CORO7_ENST00000537233.2_Intron|CORO7_ENST00000251166.4_Intron|CORO7-PAM16_ENST00000572467.1_Intron|CORO7_ENST00000574025.1_Intron|CORO7_ENST00000423908.2_Intron|CORO7_ENST00000539968.1_Intron	NM_138440.2	NP_612449.2	Q6EMK4	VASN_HUMAN	vasorin	573						extracellular region|integral to membrane		p.N573T(1)		breast(1)|lung(3)|prostate(1)|skin(1)	6						CGCGAGGGCAACCTGCCGCTCC	0.772													2	4	---	---	---	---					
KAL1	3730	broad.mit.edu	37	X	8503766	8503766	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ZG-A9L0-01A-11D-A41K-08	TCGA-ZG-A9L0-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ed594b57-98b2-4fcf-b6a4-e507919e6b7d	b1de224d-ae13-4f56-813c-4326b207e7ac	g.chrX:8503766delA	ENST00000262648.3	-	12	1857	c.1708delT	c.(1708-1710)ctfs	p.S570fs	KAL1_ENST00000481896.1_5'UTR	NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	570	Fibronectin type-III 4.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						ATCTTCCAAGAAAAGTGACCG	0.488													31	14	---	---	---	---