Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HERC1	8925	broad.mit.edu	37	15	63991137	63991137	+	Silent	SNP	G	G	A			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr15:63991137G>A	ENST00000443617.2	-	26	4782	c.4695C>T	c.(4693-4695)agC>agT	p.S1565S	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	1565					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						ACCAGTCTCTGCTATGTTTCA	0.393000													4	112					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73471770	73471770	+	Silent	SNP	A	A	G			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr7:73471770A>G	ENST00000358929.4	+	22	1507	c.1416A>G	c.(1414-1416)ccA>ccG	p.P472P	ELN_ENST00000414324.1_Intron|ELN_ENST00000380553.4_Intron|ELN_ENST00000380562.4_Intron|ELN_ENST00000380575.4_Intron|ELN_ENST00000380576.5_Intron|ELN_ENST00000458204.1_Intron|ELN_ENST00000357036.5_Intron|ELN_ENST00000445912.1_Intron|ELN_ENST00000320399.6_Intron|ELN_ENST00000320492.7_Intron|ELN_ENST00000252034.7_Intron|ELN_ENST00000429192.1_Intron|ELN_ENST00000380584.4_Intron			P15502	ELN_HUMAN	elastin	472	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	GCGCAGTCCCAGGTGTGCCGG	0.632000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						5	16					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr20:29628245G>A	ENST00000278882.3	+	6	627	c.247G>A	c.(247-249)Gcc>Acc	p.A83T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A88T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A83T														p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													4	94					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47696432	47696432	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr17:47696432A>C	ENST00000393331.3	-	7	861	c.391T>G	c.(391-393)Tgg>Ggg	p.W131G	SPOP_ENST00000503676.1_Missense_Mutation_p.W131G|SPOP_ENST00000393328.2_Missense_Mutation_p.W131G|SPOP_ENST00000347630.2_Missense_Mutation_p.W131G|SPOP_ENST00000504102.1_Missense_Mutation_p.W131G	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	131	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.W131G(2)|p.W131R(1)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						TTGAATCCCCAGTCTTTGCCT	0.458000										Prostate(2;0.17)			50	92					0	0	1	0	0
CWH43	80157	broad.mit.edu	37	4	49034677	49034677	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr4:49034677G>A	ENST00000226432.4	+	12	1786	c.1603G>A	c.(1603-1605)Gtt>Att	p.V535I	CWH43_ENST00000513409.1_Missense_Mutation_p.V508I	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	535					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						CACATTGACCGTTAACATTTC	0.463000													4	188					0	0	1	0	0
C9orf91	203197	broad.mit.edu	37	9	117405508	117405508	+	Missense_Mutation	SNP	C	C	G			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr9:117405508C>G	ENST00000374049.4	+	9	1384	c.947C>G	c.(946-948)aCg>aGg	p.T316R	C9orf91_ENST00000288502.4_Missense_Mutation_p.T315R	NM_153045.3	NP_694590.2	Q5VZI3	CI091_HUMAN	chromosome 9 open reading frame 91	315						integral to membrane				endometrium(2)|large_intestine(3)|lung(5)|pancreas(1)|skin(1)|urinary_tract(1)	13						ACACGACACACGAACTCTCCG	0.587000													23	72					0	0	1	0	0
FBXO39	162517	broad.mit.edu	37	17	6690256	6690256	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr17:6690256G>A	ENST00000321535.4	+	3	1311	c.1181G>A	c.(1180-1182)tGt>tAt	p.C394Y		NM_153230.2	NP_694962.1	Q8N4B4	FBX39_HUMAN	F-box protein 39	394										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	26						GAACGGCAGTGTGCCCTGCGT	0.512000													34	56					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54777747	54777747	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chrX:54777747G>T	ENST00000218436.6	-	12	3448	c.3419C>A	c.(3418-3420)aCc>aAc	p.T1140N		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	1140					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										CTGGAAGTAGGTGCGAGTCTG	0.607000													28	3					1.33986e-20	1.47058e-20	1	1	0
APOL4	80832	broad.mit.edu	37	22	36587725	36587725	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr22:36587725T>C	ENST00000332987.1	-	7	864	c.442A>G	c.(442-444)Atc>Gtc	p.I148V	APOL4_ENST00000429038.2_3'UTR|APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000404685.3_3'UTR|APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000352371.1_Missense_Mutation_p.I151V			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	152					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						ACAGACAGGATGCCAGTGGAG	0.532000													11	18					0	0	1	0	0
BRIX1	55299	broad.mit.edu	37	5	34925038	34925038	+	Silent	SNP	A	A	G			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr5:34925038A>G	ENST00000336767.5	+	9	1113	c.750A>G	c.(748-750)ggA>ggG	p.G250G	BRIX1_ENST00000506023.1_3'UTR	NM_018321.3	NP_060791.3	Q8TDN6	BRX1_HUMAN	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)	250					ribosome biogenesis|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|protein binding			central_nervous_system(1)|large_intestine(2)|lung(1)	4						GTTTTGGAGGACCAACTTTAT	0.378000													27	38					0	0	1	0	0
VCL	7414	broad.mit.edu	37	10	75843162	75843162	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr10:75843162G>T	ENST00000211998.4	+	8	1007	c.913G>T	c.(913-915)Gaa>Taa	p.E305*	VCL_ENST00000478896.2_Intron|VCL_ENST00000372755.3_Nonsense_Mutation_p.E305*|VCL_ENST00000417648.2_Intron	NM_014000.2	NP_054706.1	P18206	VINC_HUMAN	vinculin	305	3 X 112 AA tandem repeats.|N-terminal globular head.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Prostate(51;0.0112)					GATCTTAGATGAAGCTGGAAA	0.428000													21	40					9.39395e-14	1.00649e-13	1	1	0
DCXR	51181	broad.mit.edu	37	17	79993878	79993878	+	Silent	SNP	C	C	T			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr17:79993878C>T	ENST00000306869.2	-	8	742	c.693G>A	c.(691-693)acG>acA	p.T231T		NM_001195218.1|NM_016286.3	NP_001182147.1|NP_057370.1	Q7Z4W1	DCXR_HUMAN	dicarbonyl/L-xylulose reductase	231					D-xylose metabolic process|glucose metabolic process|protein homotetramerization|xylulose metabolic process	membrane	binding|L-xylulose reductase (NADP+) activity			kidney(1)|lung(3)	4	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			AAGTGGAACCCGTGGTCATGC	0.622000													5	83					0	0	1	0	0
ZNF347	84671	broad.mit.edu	37	19	53644064	53644064	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr19:53644064T>C	ENST00000452676.2	-	5	2446	c.2020A>G	c.(2020-2022)Aga>Gga	p.R674G	ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000601469.2_Missense_Mutation_p.R674G|ZNF347_ENST00000334197.7_Missense_Mutation_p.R673G	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	673					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		GTATGAACTCTCCGATGTCTT	0.428000													5	147					0	0	1	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202538279	202538279	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr1:202538279G>C	ENST00000406302.3	+	23	2969	c.2816G>C	c.(2815-2817)aGg>aCg	p.R939T	PPP1R12B_ENST00000391959.3_Missense_Mutation_p.R165T|PPP1R12B_ENST00000290419.5_3'UTR|PPP1R12B_ENST00000336894.4_Missense_Mutation_p.R939T|PPP1R12B_ENST00000367270.4_Missense_Mutation_p.R165T	NM_001197131.1|NM_002481.3	NP_001184060.1|NP_002472.2	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory subunit 12B	939					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(17)|ovary(4)|skin(3)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(75;0.166)			AAACAGGAGAGGCGAGCCTTG	0.443000													28	48					0	0	1	0	0
MAP2K3	5606	broad.mit.edu	37	17	21208397	21208397	+	Missense_Mutation	SNP	G	G	A	rs148612005	byFrequency	TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr17:21208397G>A	ENST00000342679.4	+	9	980	c.731G>A	c.(730-732)gGc>gAc	p.G244D	MAP2K3_ENST00000316920.6_Missense_Mutation_p.G215D|MAP2K3_ENST00000361818.5_Missense_Mutation_p.G215D	NM_145109.2	NP_659731.1	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	244	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity								COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		AACCAGAAGGGCTACAATGTC	0.637000													16	120					0	0	1	0	0
IMPAD1	54928	broad.mit.edu	37	8	57878868	57878868	+	Silent	SNP	A	A	G			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr8:57878868A>G	ENST00000262644.4	-	4	948	c.690T>C	c.(688-690)tcT>tcC	p.S230S		NM_017813.4	NP_060283.3	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	230						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				CATTGTAGGAAGAGCGGGCTT	0.418000													25	84					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11957962	11957962	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr11:11957962G>A	ENST00000339865.5	+	16	2541	c.1778G>A	c.(1777-1779)gGg>gAg	p.G593E	USP47_ENST00000539466.1_5'UTR|USP47_ENST00000399455.2_Missense_Mutation_p.G681E|USP47_ENST00000527733.1_Missense_Mutation_p.G661E	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	681					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		ACACCAATGGGGCTTCTACTA	0.423000													32	70					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5462222	5462222	+	Silent	SNP	A	A	G			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr5:5462222A>G	ENST00000296564.7	+	13	2997	c.2775A>G	c.(2773-2775)tcA>tcG	p.S925S		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	925										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						AAAGCATTTCACCAGAAGTTT	0.398000													11	28					0	0	1	0	0
MSH6	2956	broad.mit.edu	37	2	48027960	48027960	+	Missense_Mutation	SNP	A	A	C			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr2:48027960A>C	ENST00000234420.4	+	4	2990	c.2838A>C	c.(2836-2838)gaA>gaC	p.E946D	MSH6_ENST00000538136.1_Missense_Mutation_p.E644D|FBXO11_ENST00000405808.1_Intron|MSH6_ENST00000540021.1_Missense_Mutation_p.E816D	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	946					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ACATAAGAGAAAATGAACAGA	0.458000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				12	29					0	0	1	0	0
NAB2	4665	broad.mit.edu	37	12	57485584	57485584	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr12:57485584C>T	ENST00000300131.3	+	2	1138	c.760C>T	c.(760-762)Cgg>Tgg	p.R254W	NAB2_ENST00000342556.6_Missense_Mutation_p.R254W|NAB2_ENST00000357680.4_Missense_Mutation_p.R254W|NAB2_ENST00000554718.1_3'UTR	NM_005967.3	NP_005958.1	Q15742	NAB2_HUMAN	NGFI-A binding protein 2 (EGR1 binding protein 2)	254					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						GAGGATCTTCCGGAGCTTCCC	0.592000													51	65					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31226130	31226130	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr16:31226130C>T	ENST00000322122.3	+	2	355	c.71C>T	c.(70-72)cCc>cTc	p.P24L		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	24					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						TTCGACGCGCCCGTGACAGCC	0.721000													6	15					0	0	1	0	0
SCAF11	9169	broad.mit.edu	37	12	46316920	46316920	+	Silent	SNP	A	A	C			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr12:46316920A>C	ENST00000465950.1	-	3	4188	c.2979T>G	c.(2977-2979)tcT>tcG	p.S993S	SCAF11_ENST00000419565.2_Silent_p.S1308S|SCAF11_ENST00000369367.3_Silent_p.S1308S|SCAF11_ENST00000549162.1_Silent_p.S1116S|SCAF11_ENST00000550629.1_5'UTR			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1308					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TACTTACATGAGAAGAACTAG	0.378000													31	55					0	0	1	0	0
ITGA2	3673	broad.mit.edu	37	5	52361704	52361704	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr5:52361704C>T	ENST00000296585.5	+	15	1983	c.1840C>T	c.(1840-1842)Cat>Tat	p.H614Y		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	614					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				CTTTAGGAGCCATCTCCAGTA	0.453000													43	15					0	0	1	0	0
TMBIM6	7009	broad.mit.edu	37	12	50149485	50149485	+	Missense_Mutation	SNP	A	A	G			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr12:50149485A>G	ENST00000423828.1	+	4	735	c.407A>G	c.(406-408)cAt>cGt	p.H136R	TMBIM6_ENST00000547798.1_Missense_Mutation_p.H41R|TMBIM6_ENST00000552699.1_Missense_Mutation_p.H136R|TMBIM6_ENST00000267115.5_Missense_Mutation_p.H78R|TMBIM6_ENST00000395006.4_Missense_Mutation_p.H78R|TMBIM6_ENST00000549385.1_Missense_Mutation_p.H78R	NM_001098576.1	NP_001092046.1	P55061	BI1_HUMAN	transmembrane BAX inhibitor motif containing 6	78					apoptosis|negative regulation of apoptosis	endoplasmic reticulum|insoluble fraction|integral to plasma membrane|nucleus				lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	6						CCTCATAGCCATGAAACTGAA	0.428000													94	121					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098909	11098909	+	RNA	SNP	C	C	T			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr21:11098909C>T	ENST00000470054.1	-	0	16									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		agcagctcagcgggagatacc	0.587000													3	12					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961838	34961838	+	Missense_Mutation	SNP	C	C	T			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chrX:34961838C>T	ENST00000329357.5	+	1	926	c.890C>T	c.(889-891)cCg>cTg	p.P297L		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	297	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						CATCTCCACCCGGAGCCTCCT	0.632000													39	14					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S|FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													4	96					0	0	1	0	0
MARCH4	57574	broad.mit.edu	37	2	217124081	217124081	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr2:217124081G>A	ENST00000273067.4	-	4	2953	c.1187C>T	c.(1186-1188)cCc>cTc	p.P396L		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	396						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GCTGCCTGGGGGACTTCGCTG	0.617000													24	63					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	50					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16892268	16892268	+	Missense_Mutation	SNP	G	G	C			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr1:16892268G>C	ENST00000430580.2	-	27	3811	c.2924C>G	c.(2923-2925)cCt>cGt	p.P975R		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	975	NBPF 6.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CAAGACTTCAGGCTCTACTGC	0.488000													38	689					0	0	1	0	0
RRN3P2	0	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													8	101					0	0	1	0	0
KLHL28	54813	broad.mit.edu	37	14	45403573	45403573	+	Missense_Mutation	SNP	G	G	T			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr14:45403573G>T	ENST00000396128.4	-	3	1207	c.1088C>A	c.(1087-1089)aCa>aAa	p.T363K	KLHL28_ENST00000355081.2_Missense_Mutation_p.T377K	NM_017658.3	NP_060128.2	Q9NXS3	KLH28_HUMAN	kelch-like family member 28	363										breast(2)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CCAAGTATTTGTATCAGGATT	0.398000													19	80					3.32936e-07	3.48421e-07	1	1	0
CCDC85A	114800	broad.mit.edu	37	2	56599555	56599555	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr2:56599555G>A	ENST00000407595.2	+	4	1896	c.1394G>A	c.(1393-1395)cGg>cAg	p.R465Q	RP11-482H16.1_ENST00000607540.1_RNA	NM_001080433.1	NP_001073902.1	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	465										breast(6)|cervix(2)|endometrium(5)|kidney(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)	38			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			AGAGCCCGGCGGGTCTTGCAG	0.522000													3	6					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50994336	50994336	+	Missense_Mutation	SNP	G	G	A			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr18:50994336G>A	ENST00000442544.2	+	25	4308	c.3692G>A	c.(3691-3693)cGg>cAg	p.R1231Q	DCC_ENST00000581580.1_Missense_Mutation_p.R866Q	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1231					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CGAGCCCCCCGGGCCAAGCTC	0.493000													24	39					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71346978	71346978	+	Missense_Mutation	SNP	T	T	C			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr4:71346978T>C	ENST00000413702.1	+	4	805	c.517T>C	c.(517-519)Tct>Cct	p.S173P	MUC7_ENST00000514512.1_3'UTR|MUC7_ENST00000304887.5_Missense_Mutation_p.S173P|MUC7_ENST00000456088.1_Missense_Mutation_p.S173P	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	173	Thr-rich.					extracellular region	protein binding	p.S173P(3)		central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			ACCCACACCTTCTGCAACTAC	0.522000													5	113					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207644418	207644418	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr1:207644418delT	ENST00000367057.3	+	8	1668	c.1479delT	c.(1477-1479)tcfs	p.S494fs	CR2_ENST00000367059.3_Frame_Shift_Del_p.S494fs|CR2_ENST00000367058.3_Frame_Shift_Del_p.S494fs|CR2_ENST00000458541.2_Frame_Shift_Del_p.S494fs	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	494	Sushi 8.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						ATGTCAACTCTTCTTGTGGTG	0.468													51	71	---	---	---	---					
PIKFYVE	200576	broad.mit.edu	37	2	209204848	209204848	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr2:209204848delT	ENST00000264380.4	+	31	5082	c.4924delT	c.(4924-4926)ttfs	p.F1642fs		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1642					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						TCCTATTCCATTTCCTTTGTA	0.373													46	78	---	---	---	---					
DBR1	51163	broad.mit.edu	37	3	137880741	137880743	+	In_Frame_Del	DEL	TCG	TCG	-	rs2622736	byFrequency	TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr3:137880741_137880743delTCG	ENST00000260803.4	-	8	1776_1778	c.1623_1625delCGA	c.(1621-1626)gat>ga	p.DD541del	DBR1_ENST00000505015.2_In_Frame_Del_p.DD307del	NM_016216.3	NP_057300.2	Q9UK59	DBR1_HUMAN	debranching RNA lariats 1	541						nucleus	metal ion binding|RNA lariat debranching enzyme activity			NS(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	15						TTAAGCTGCATCGTCATCATCAT	0.394													9	118	---	---	---	---					
UBLCP1	134510	broad.mit.edu	37	5	158697638	158697638	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr5:158697638delT	ENST00000296786.6	+	5	761	c.435delT	c.(433-435)gafs	p.D145fs		NM_145049.3	NP_659486.2	Q8WVY7	UBCP1_HUMAN	ubiquitin-like domain containing CTD phosphatase 1	145	FCP1 homology.					nucleus	phosphoprotein phosphatase activity			endometrium(1)|kidney(3)|large_intestine(4)|ovary(1)	9	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TAGATGTTGATTATACATTAT	0.323													16	27	---	---	---	---					
FAM66B	0	broad.mit.edu	37	8	7191583	7191584	+	RNA	DEL	AC	AC	-			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr8:7191583_7191584delAC	ENST00000606573.1	-	0	703																											acgcacgcaaacacacacacac	0.510													3	5	---	---	---	---					
FER1L6	654463	broad.mit.edu	37	8	125047624	125047628	+	Frame_Shift_Del	DEL	TAGGC	TAGGC	-			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr8:125047624_125047628delTAGGC	ENST00000522917.1	+	19	2599_2603	c.2393_2397delTAGGC	c.(2392-2397)gfs	p.VG798fs	FER1L6-AS1_ENST00000518567.1_RNA|FER1L6_ENST00000399018.1_Frame_Shift_Del_p.VG798fs	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	798						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AACTTGCCAGTAGGCTATGAAGCAG	0.556													12	68	---	---	---	---					
TTF1	7270	broad.mit.edu	37	9	135254513	135254514	+	Frame_Shift_Ins	INS	-	-	T			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr9:135254513_135254514insT	ENST00000334270.2	-	10	2435_2436	c.2396_2397insA	c.(2395-2397)tgtfs	p.C799fs	TTF1_ENST00000461970.1_5'UTR	NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	799					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		TAGTTTGAACGTAAGATGGAGG	0.297													28	43	---	---	---	---					
ZDHHC8P1	0	broad.mit.edu	37	22	23744098	23744098	+	RNA	DEL	G	G	-			TCGA-ZG-A9ND-01A-11D-A41K-08	TCGA-ZG-A9ND-10A-01D-A41N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e54ecf05-37ff-4c12-8ea9-5c8f2ce9b32f	1ed242e5-cb06-4cb6-b21f-fef81d717693	g.chr22:23744098delG	ENST00000255890.4	-	0	368																											GGCAGGCGTCGGGGGGTGGCG	0.632													2	4	---	---	---	---