Hugo_Symbol Entrez_Gene_Id Center NCBI_Build Chromosome Start_Position End_Position Strand Variant_Classification Variant_Type Reference_Allele Tumor_Seq_Allele1 Tumor_Seq_Allele2 dbSNP_RS dbSNP_Val_Status Tumor_Sample_Barcode Matched_Norm_Sample_Barcode Match_Norm_Seq_Allele1 Match_Norm_Seq_Allele2 Tumor_Validation_Allele1 Tumor_Validation_Allele2 Match_Norm_Validation_Allele1 Match_Norm_Validation_Allele2 Verification_Status Validation_Status Mutation_Status Sequencing_Phase Sequence_Source Validation_Method Score BAM_File Sequencer Tumor_Sample_UUID Matched_Norm_Sample_UUID chromosome_name start stop reference variant type gene_name transcript_name transcript_species transcript_source transcript_version strand transcript_status trv_type c_position amino_acid_change ucsc_cons domain all_domains deletion_substructures transcript_error default_gene_name gene_name_source ensembl_gene_id tier dbSNP GMAF n_ref_count n_alt_count normal_vaf t_ref_count t_alt_count tumor_vaf n_ref_count_val n_alt_count_val normal_vaf_val t_ref_count_val t_alt_count_val tumor_vaf_val SDK1 0 genome.wustl.edu 37 7 4091396 4091396 + Silent SNP C C T TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 C C C T C C Unknown Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 7 4091396 4091396 C T SNP SDK1 ENST00000404826 human ensembl 74_37 +1 known silent c.2845 p.L949 0.979 pfam_Fibronectin_type3,superfamily_Fibronectin_type3,smart_Fibronectin_type3,pfscan_Fibronectin_type3 pfam_Fibronectin_type3,pfam_Ig_I-set,pfam_Immunoglobulin,pfam_Ig_V-set,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom - no_errors SDK1 HGNC ENSG00000146555 tier1 - - 32 0 0.00 190 34 15.18 120 0 0.00 468 77 14.10 FEM1C 0 genome.wustl.edu 37 5 114860080 114860080 + Silent SNP G G A TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 G G G A G G Unknown Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 5 114860080 114860080 G A SNP FEM1C ENST00000274457 human ensembl 74_37 -1 known silent c.1779 p.V593 1.000 NULL pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,prints_Ankyrin_rpt - no_errors FEM1C HGNC ENSG00000145780 tier1 - - 45 0 0.00 79 15 15.79 80 0 0.00 126 32 20.25 ADAM32 0 genome.wustl.edu 37 8 39080584 39080584 + Missense_Mutation SNP G G C TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 G G G C G G Unknown Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 8 39080584 39080584 G C SNP ADAM32 ENST00000379907 human ensembl 74_37 +1 known missense c.1352 p.R451T 0.978 pfam_Blood-coag_inhib_Disintegrin,superfamily_Blood-coag_inhib_Disintegrin,smart_Blood-coag_inhib_Disintegrin,pfscan_Blood-coag_inhib_Disintegrin pfam_Peptidase_M12B,pfam_Peptidase_M12B_N,pfam_ADAM_Cys-rich,pfam_Blood-coag_inhib_Disintegrin,superfamily_Blood-coag_inhib_Disintegrin,smart_Blood-coag_inhib_Disintegrin,smart_ADAM_Cys-rich,pfscan_Blood-coag_inhib_Disintegrin,pfscan_EG-like_dom,pfscan_Peptidase_M12B - no_errors ADAM32 HGNC ENSG00000197140 tier1 - - 28 0 0.00 23 3 11.54 103 0 0.00 92 18 16.36 FEM1C 0 genome.wustl.edu 37 5 114860112 114860112 + Missense_Mutation SNP G G A TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 G G G A G G Unknown Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 5 114860112 114860112 G A SNP FEM1C ENST00000274457 human ensembl 74_37 -1 known missense c.1747 p.H583Y 1.000 NULL pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,prints_Ankyrin_rpt - no_errors FEM1C HGNC ENSG00000145780 tier1 - - 39 0 0.00 75 18 19.35 86 0 0.00 130 30 18.75 CP 0 genome.wustl.edu 37 3 148919931 148919931 + Missense_Mutation SNP G G C TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 G G G C G G Unknown Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 3 148919931 148919931 G C SNP CP ENST00000264613 human ensembl 74_37 -1 known missense c.1306 p.R436G 0.000 superfamily_Cupredoxin pfam_Cu-oxidase_2,pfam_Cu-oxidase_3,pfam_Cu-oxidase,superfamily_Cupredoxin - no_errors CP HGNC ENSG00000047457 tier1 - - 43 0 0.00 45 8 15.09 128 0 0.00 134 22 14.01 FEM1C 0 genome.wustl.edu 37 5 114860070 114860070 + Missense_Mutation SNP G G A TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 G G G A G G Unknown Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 5 114860070 114860070 G A SNP FEM1C ENST00000274457 human ensembl 74_37 -1 known missense c.1789 p.H597Y 1.000 NULL pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,prints_Ankyrin_rpt - no_errors FEM1C HGNC ENSG00000145780 tier1 - - 42 0 0.00 80 16 16.49 74 0 0.00 118 28 19.05 FLG 0 genome.wustl.edu 37 1 152278006 152278006 + Missense_Mutation SNP C C T TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 C C C T C C Unknown Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 1 152278006 152278006 C T SNP FLG ENST00000368799 human ensembl 74_37 -1 known missense c.9356 p.G3119E 0.003 NULL pfam_Filaggrin,pfam_S100_Ca-bd_sub,pfscan_EF_hand_dom,prints_Filaggrin - no_errors FLG HGNC ENSG00000143631 tier1 - - 60 0 0.00 62 14 18.42 12 0 0.00 13 6 31.58 KDR 0 genome.wustl.edu 37 4 55980332 55980332 + Missense_Mutation SNP A A T TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 A A A T A A Unknown Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 4 55980332 55980332 A T SNP KDR ENST00000263923 human ensembl 74_37 -1 known missense c.759 p.N253K 0.692 pfam_Ig_I-set,pfam_Ig_V-set,pfam_Immunoglobulin,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Ig_I-set,pfam_Prot_kinase_dom,pfam_Ig_V-set,pfam_Immunoglobulin,pfam_CD80_C2-set,superfamily_Kinase-like_dom,smart_Ig_sub,smart_Ig_sub2,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom,prints_VEGFR2_rcpt - no_errors KDR HGNC ENSG00000128052 tier1 - - 50 0 0.00 50 6 10.71 197 0 0.00 160 15 8.57 T10 0 genome.wustl.edu 37 11 34130376 34130376 + Missense_Mutation SNP A A G TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 A A A G A A Unknown Valid Somatic Phase_IV WXS Hybrid_Capture_Illumina_Seq Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 11 34130376 34130376 A G SNP T10 ENST00000257829 human ensembl 74_37 +1 known missense c.196 p.S66G 1.000 NULL pfam_Helicase_dom,pfam_DUF1726,superfamily_Acyl_CoA_acyltransferase,superfamily_P-loop_NTPase,pfscan_GT_dom - no_errors T10 HGNC ENSG00000135372 tier1 - - 57 0 0.00 55 5 8.33 141 0 0.00 102 10 8.93 GAPVD1 0 genome.wustl.edu 37 9 128025963 128025989 + Splice_Site DEL CAGCACTCCATCTGTAGGTATGTCTGT CAGCACTCCATCTGTAGGTATGTCTGT - TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 CAGCACTCCATCTGTAGGTATGTCTGT CAGCACTCCATCTGTAGGTATGTCTGT Unknown Untested Somatic Phase_IV WXS none Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 9 128025963 128025989 CAGCACTCCATCTGTAGGTATGTCTGT - DEL GAPVD1 ENST00000469528 human ensembl 74_37 +1 known splice_site_del c.NULL NULL 1.000:1.000:1.000:1.000:1.000:0.999:0.996:0.980:0.970:0.963:0.961:0.959:0.952:0.948:0.947:0.950:0.961:0.966:0.966:0.969:0.974:0.982:0.984:0.985:0.984:0.985:0.993 - - - no_errors GAPVD1 HGNC ENSG00000165219 tier1 7 0 0.00 5 0 0.00 7 0 0.00 5 0 0.00 DDX11L9 0 genome.wustl.edu 37 15 102516816 102516816 + R SNP G G T TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 G G Unknown Untested Somatic Phase_IV WXS none Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 15 102516816 102516816 G T SNP DDX11L9 ENST00000559159 human ensembl 74_37 -1 known rna NULL NULL 0.000 - - - no_errors DDX11L9 HGNC ENSG00000248472 tier1 - - 9 0 0.00 5 4 44.44 0 0 0.00 0 0 0.00 DNM1P51 0 genome.wustl.edu 37 15 84959328 84959328 + R SNP G G A TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 G G Unknown Untested Somatic Phase_IV WXS none Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 15 84959328 84959328 G A SNP DNM1P51 ENST00000558801 human ensembl 74_37 -1 known rna NULL NULL 0.754 - - - no_errors DNM1P51 HGNC ENSG00000235370 tier1 - - 54 0 0.00 71 15 17.44 0 0 0.00 3 0 0.00 MSH3 0 genome.wustl.edu 37 5 79950709 79950717 + In_Frame_Del DEL GCAGCGGCC GCAGCGGCC - TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 GCAGCGGCC GCAGCGGCC Unknown Untested Somatic Phase_IV WXS none Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 5 79950709 79950717 GCAGCGGCC - DEL MSH3 ENST00000265081 human ensembl 74_37 +1 known in_frame_del c.163_171 p.AAA58in_frame_del 0.338:0.304:0.271:0.238:0.205:0.172:0.140:0.107:0.075 NULL pfam_D_mismatch_repair_MutS_C,pfam_D_mismatch_repair_MutS_core,pfam_D_mmatch_repair_MutS_con_dom,pfam_D_mismatch_repair_MutS-lik_N,pfam_D_mismatch_repair_MutS_clamp,superfamily_D_mismatch_repair_MutS_core,superfamily_P-loop_NTPase,superfamily_D_mismatch_repair_MutS_N,superfamily_D_mmatch_repair_MutS_con_dom,smart_D_mismatch_repair_MutS_core,smart_D_mismatch_repair_MutS_C - no_errors MSH3 HGNC ENSG00000113318 tier1 0 0 0.00 0 1 100.00 0 0 0.00 0 1 100.00 MT-CO1 0 genome.wustl.edu 37 MT 7176 7176 + Missense_Mutation SNP T T C TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 T T Unknown Untested Somatic Phase_IV WXS none Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 MT 7176 7176 T C SNP MT-CO1 ENST00000361624 human ensembl 74_37 +1 known missense c.1273 p.F425L NULL pfam_Cyt_c_Oxase_su1,superfamily_Cyt_c_Oxase_su1_dom,pfscan_Cyt_c_Oxase_su1_dom,prints_Cyt_c_Oxase_su1 pfam_Cyt_c_Oxase_su1,superfamily_Cyt_c_Oxase_su1_dom,pfscan_Cyt_c_Oxase_su1_dom,prints_Cyt_c_Oxase_su1 - no_errors MT-CO1 HGNC ENSG00000198804 tier1 - - 17 0 0.00 73 22 23.16 2 0 0.00 0 0 0.00 TBC1D3 0 genome.wustl.edu 37 17 36339584 36339584 + Missense_Mutation SNP G G T TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 G G Unknown Untested Somatic Phase_IV WXS none Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 17 36339584 36339584 G T SNP TBC1D3 ENST00000354664 human ensembl 74_37 -1 known missense c.1073 p.P358Q 1.000 NULL pfam_Rab-GTPase-TBC_dom,superfamily_Rab-GTPase-TBC_dom,smart_Rab-GTPase-TBC_dom,pfscan_Rab-GTPase-TBC_dom - no_errors TBC1D3 HGNC ENSG00000197681 tier1 - - 25 0 0.00 15 7 31.82 0 0 0.00 0 0 0.00 FAM153C 0 genome.wustl.edu 37 5 177457620 177457620 + Silent SNP C C T TCGA-DX-A23T-01A-11D-A26G-09 TCGA-DX-A23T-10A-01D-A26G-09 C C Unknown Untested Somatic Phase_IV WXS none Illumina HiSeq dbc6f717-fbc5-40d2-b105-da9a150b454f b5482bab-e0c8-4a78-b485-a9d4bcfe9203 5 177457620 177457620 C T SNP FAM153C ENST00000511189 human ensembl 74_37 +1 novel silent c.27 p.L9 0.000 NULL prints_FAM153 - no_errors FAM153C HGNC ENSG00000204677 tier1 rs200476067 - 40 0 0.00 41 6 12.77 23 0 0.00 40 2 4.76