Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
ABCA13	0	genome.wustl.edu	37	7	48314976	48314976	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	7	48314976	48314976	G	T	SNP	ABCA13	ENST00000435803	human	ensembl	74_37	+1	known	nonsense	c.5713	p.E1905*	0.014	NULL	pfam_ABC_transporter-like,superfamily_P-loop_NTPase,smart_AAA+_ATPase,pfscan_ABC_transporter-like	-	no_errors	ABCA13	HGNC	ENSG00000179869	tier1	-	-	105	0	0.00	49	43	46.74	110	0	0.00	51	45	46.88
PKHD1	0	genome.wustl.edu	37	6	51930781	51930781	+	Silent	SNP	G	G	C			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	6	51930781	51930781	G	C	SNP	PKHD1	ENST00000371117	human	ensembl	74_37	-1	known	silent	c.873	p.T291	0.006	pfam_IPT,superfamily_Ig_E-set,smart_IPT	pfam_IPT,pfam_G8_domain,superfamily_Ig_E-set,superfamily_Pectin_lyase_fold/virulence,smart_IPT,smart_PbH1	-	no_errors	PKHD1	HGNC	ENSG00000170927	tier1	-	-	319	0	0.00	152	150	49.67	105	0	0.00	76	65	46.10
SNHG14	0	genome.wustl.edu	37	15	25328601	25328601	+	R	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	15	25328601	25328601	C	T	SNP	SNHG14	ENST00000383025	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.002	-	-	-	no_errors	SNHG14	HGNC	ENSG00000224078	tier1	-	-	246	0	0.00	117	117	50.00	115	1	0.86	26	44	62.86
MUC16	0	genome.wustl.edu	37	19	9066039	9066039	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	19	9066039	9066039	G	A	SNP	MUC16	ENST00000397910	human	ensembl	74_37	-1	known	missense	c.21407	p.T7136M	0.000	NULL	pfam_SEA_dom,smart_SEA_dom,pfscan_SEA_dom	-	no_errors	MUC16	HGNC	ENSG00000181143	tier1	-	-	272	0	0.00	127	128	50.20	141	1	0.70	58	47	44.76
COL6A1	0	genome.wustl.edu	37	21	47423972	47423972	+	R	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	21	47423972	47423972	C	T	SNP	COL6A1	ENST00000486023	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.010	-	-	-	no_errors	COL6A1	HGNC	ENSG00000142156	tier1	-	-	76	0	0.00	66	14	17.28	82	0	0.00	54	13	19.40
HIST2H3PS2	0	genome.wustl.edu	37	1	149400241	149400241	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	1	149400241	149400241	A	T	SNP	HIST2H3PS2	ENST00000392948	human	ensembl	74_37	-1	putative	missense	c.302	p.L101Q	1.000	pfam_Histone_core_D,superfamily_Histone-fold,smart_Histone_H3,prints_Histone_H3	pfam_Histone_core_D,superfamily_Histone-fold,smart_Histone_H3,prints_Histone_H3	-	no_errors	HIST2H3PS2	HGNC	ENSG00000203818	tier1	-	-	729	0	0.00	604	171	22.06	46	0	0.00	47	16	25.40
MAGI2	0	genome.wustl.edu	37	7	78636524	78636524	+	Splice_Site	SNP	T	T	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	7	78636524	78636524	T	A	SNP	MAGI2	ENST00000354212	human	ensembl	74_37	-1	known	splice_site	c.302-2	e2-2	1.000	-	-	-	no_errors	MAGI2	HGNC	ENSG00000187391	tier1	-	-	78	0	0.00	54	16	22.86	68	0	0.00	59	29	32.58
MEIG1	0	genome.wustl.edu	37	10	15014543	15014543	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	10	15014543	15014543	A	G	SNP	MEIG1	ENST00000378240	human	ensembl	74_37	+1	known	missense	c.170	p.K57R	1.000	NULL	NULL	-	no_errors	MEIG1	HGNC	ENSG00000197889	tier1	-	-	173	0	0.00	84	69	45.10	142	0	0.00	52	42	44.68
PSTPIP2	0	genome.wustl.edu	37	18	43571883	43571883	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	18	43571883	43571883	C	T	SNP	PSTPIP2	ENST00000409746	human	ensembl	74_37	-1	known	missense	c.905	p.G302E	0.170	NULL	pfam_FCH_dom,smart_FCH_dom,pfscan_FCH_dom	-	no_errors	PSTPIP2	HGNC	ENSG00000152229	tier1	-	-	128	0	0.00	67	63	48.09	94	1	1.05	36	28	43.08
ENSG00000244227	0	genome.wustl.edu	37	3	167632987	167632987	+	R	SNP	C	C	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	3	167632987	167632987	C	A	SNP	ENSG00000244227	ENST00000459923	human	ensembl	74_37	+1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	RP11-298O21.5	Clone_based_vega_gene	ENSG00000244227	tier1	-	-	109	0	0.00	56	72	56.25	104	0	0.00	27	43	61.43
HFM1	0	genome.wustl.edu	37	1	91726828	91726828	+	R	SNP	T	T	C			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	1	91726828	91726828	T	C	SNP	HFM1	ENST00000462405	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	HFM1	HGNC	ENSG00000162669	tier1	-	-	89	0	0.00	51	41	44.57	54	0	0.00	66	51	43.59
MPDZ	0	genome.wustl.edu	37	9	13223587	13223587	+	Silent	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	9	13223587	13223587	C	T	SNP	MPDZ	ENST00000319217	human	ensembl	74_37	-1	known	silent	c.516	p.E172	0.997	pfam_PDZ,superfamily_PDZ,smart_PDZ,pfscan_PDZ	pfam_PDZ,pfam_L27_2,superfamily_PDZ,smart_PDZ,pfscan_L27,pfscan_PDZ	-	no_errors	MPDZ	HGNC	ENSG00000107186	tier1	-	-	125	0	0.00	63	44	41.12	123	1	0.81	38	37	49.33
MYH2	0	genome.wustl.edu	37	17	10432961	10432961	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	17	10432961	10432961	G	C	SNP	MYH2	ENST00000245503	human	ensembl	74_37	-1	known	missense	c.3037	p.L1013V	1.000	superfamily_Prefoldin	pfam_Myosin_tail,pfam_Myosin_head_motor_dom,pfam_Myosin_N,superfamily_P-loop_NTPase,superfamily_Prefoldin,superfamily_Ribosomal_L29,superfamily_t-SRE,smart_Myosin_head_motor_dom,smart_IQ_motif_EF-hand-BS,pfscan_IQ_motif_EF-hand-BS,prints_Myosin_head_motor_dom	-	no_errors	MYH2	HGNC	ENSG00000125414	tier1	-	-	373	0	0.00	3600	953	20.91	47	0	0.00	487	121	19.90
TTN	0	genome.wustl.edu	37	2	179431620	179431620	+	Silent	SNP	A	A	G			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	2	179431620	179431620	A	G	SNP	TTN	ENST00000342992	human	ensembl	74_37	-1	known	silent	c.71535	p.D23845	1.000	pfam_Fibronectin_type3,superfamily_Fibronectin_type3,superfamily_Calpain_domain_III,superfamily_RNaseH-like_dom,smart_Fibronectin_type3,pfscan_Fibronectin_type3	pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Immunoglobulin,pfam_Ig_V-set,pfam_Titin_Z,pfam_PPAK_motif,pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,superfamily_Fibronectin_type3,superfamily_Calpain_domain_III,superfamily_RNaseH-like_dom,smart_Ig_sub,smart_Ig_sub2,smart_Ig_V-set_subgr,smart_Fibronectin_type3,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Fibronectin_type3,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom	-	no_errors	TTN	HGNC	ENSG00000155657	tier1	-	-	63	0	0.00	41	36	46.75	98	0	0.00	52	26	32.91
SLC2A2	0	genome.wustl.edu	37	3	170723821	170723821	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	3	170723821	170723821	G	A	SNP	SLC2A2	ENST00000314251	human	ensembl	74_37	-1	known	missense	c.686	p.A229V	0.998	pfam_Sub_transporter,pfam_MFS,superfamily_MFS_dom_general_subst_transpt,pfscan_MFS_dom,tigrfam_Sugar/inositol_transpt	pfam_Sub_transporter,pfam_MFS,superfamily_MFS_dom_general_subst_transpt,prints_Sugar/inositol_transpt,prints_Glc_transpt_2,pfscan_MFS_dom,tigrfam_Sugar/inositol_transpt	-	no_errors	SLC2A2	HGNC	ENSG00000163581	tier1	-	-	61	0	0.00	17	19	52.78	58	0	0.00	13	30	69.77
HLTF	0	genome.wustl.edu	37	3	148792110	148792110	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	3	148792110	148792110	C	T	SNP	HLTF	ENST00000310053	human	ensembl	74_37	-1	known	missense	c.421	p.A141T	0.996	pfam_HIP116_Rad5p_N,smart_HIP116_Rad5p_N	pfam_SNF2_N,pfam_HIP116_Rad5p_N,pfam_Helicase_C,superfamily_P-loop_NTPase,smart_HIP116_Rad5p_N,smart_Helicase_ATP-bd,smart_Znf_RING,smart_Helicase_C,pfscan_Znf_RING,pfscan_Helicase_ATP-bd,pfscan_Helicase_C	-	no_errors	HLTF	HGNC	ENSG00000071794	tier1	-	-	62	0	0.00	59	24	28.92	106	0	0.00	114	43	27.39
MYH2	0	genome.wustl.edu	37	17	10432929	10432929	+	Silent	SNP	G	G	C			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	17	10432929	10432929	G	C	SNP	MYH2	ENST00000245503	human	ensembl	74_37	-1	known	silent	c.3069	p.V1023	1.000	superfamily_Prefoldin	pfam_Myosin_tail,pfam_Myosin_head_motor_dom,pfam_Myosin_N,superfamily_P-loop_NTPase,superfamily_Prefoldin,superfamily_Ribosomal_L29,superfamily_t-SRE,smart_Myosin_head_motor_dom,smart_IQ_motif_EF-hand-BS,pfscan_IQ_motif_EF-hand-BS,prints_Myosin_head_motor_dom	-	no_errors	MYH2	HGNC	ENSG00000125414	tier1	-	-	443	0	0.00	4268	1107	20.57	55	0	0.00	607	155	20.26
ROM1	0	genome.wustl.edu	37	11	62381881	62381881	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	11	62381881	62381881	C	T	SNP	ROM1	ENST00000278833	human	ensembl	74_37	+1	known	missense	c.742	p.L248F	1.000	pfam_Tetraspanin/Peripherin,superfamily_Tetraspanin_EC2	pfam_Tetraspanin/Peripherin,superfamily_Tetraspanin_EC2,prints_Peripherin/rom-1	-	no_errors	ROM1	HGNC	ENSG00000149489	tier1	-	-	63	0	0.00	42	22	34.38	110	1	0.90	40	44	52.38
ARFGEF1	0	genome.wustl.edu	37	8	68113722	68113722	+	Silent	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	8	68113722	68113722	C	T	SNP	ARFGEF1	ENST00000262215	human	ensembl	74_37	-1	known	silent	c.5247	p.E1749	1.000	NULL	pfam_Sec7_dom,pfam_DUF1981_Sec7_assoc,superfamily_Sec7_dom,superfamily_ARM-type_fold,smart_Sec7_dom,pfscan_Sec7_dom	-	no_errors	ARFGEF1	HGNC	ENSG00000066777	tier1	-	-	93	0	0.00	29	46	61.33	91	0	0.00	26	24	48.00
JAG1	0	genome.wustl.edu	37	20	10625904	10625904	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	20	10625904	10625904	C	G	SNP	JAG1	ENST00000254958	human	ensembl	74_37	-1	known	missense	c.2114	p.R705P	1.000	pfscan_EG-like_dom	pfam_EG-like_dom,pfam_Notch_ligand_N,pfam_DSL,pfam_EGF_extracell,pfam_EGF-like_Ca-bd_dom,smart_DSL,smart_EG-like_dom,smart_EGF-like_Ca-bd_dom,smart_VWC_out,smart_VWF_C,pfscan_DSL,pfscan_EG-like_dom	-	no_errors	JAG1	HGNC	ENSG00000101384	tier1	-	-	103	0	0.00	56	38	40.00	83	0	0.00	37	41	51.90
MDN1	0	genome.wustl.edu	37	6	90388356	90388356	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	6	90388356	90388356	C	T	SNP	MDN1	ENST00000369393	human	ensembl	74_37	-1	known	missense	c.12374	p.R4125Q	1.000	pirsf_Midasin	pfam_ATPase_dyneun-rel_AAA,pfam_ATPase_AAA-3,superfamily_P-loop_NTPase,superfamily_ARM-type_fold,smart_AAA+_ATPase,smart_VWF_A,pirsf_Midasin,pfscan_VWF_A	-	no_errors	MDN1	HGNC	ENSG00000112159	tier1	-	-	151	0	0.00	83	84	50.30	88	0	0.00	46	59	56.19
GLP2R	0	genome.wustl.edu	37	17	9760833	9760833	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	17	9760833	9760833	C	G	SNP	GLP2R	ENST00000262441	human	ensembl	74_37	+1	known	missense	c.705	p.F235L	0.000	pfam_GPCR_2_secretin-like,pfscan_GPCR_2-like,prints_GPCR_2_secretin-like	pfam_GPCR_2_secretin-like,pfam_GPCR_2_extracellular_dom,smart_GPCR_2_extracellular_dom,pfscan_GPCR_2_extracellular_dom,pfscan_GPCR_2-like,prints_GPCR_2_secretin-like	-	no_errors	GLP2R	HGNC	ENSG00000065325	tier1	-	-	189	0	0.00	1514	513	25.30	108	0	0.00	714	228	24.15
OR2T3	0	genome.wustl.edu	37	1	248637398	248637398	+	Silent	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	1	248637398	248637398	C	T	SNP	OR2T3	ENST00000359594	human	ensembl	74_37	+1	known	silent	c.747	p.H249	0.911	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR2T3	HGNC	ENSG00000196539	tier1	-	-	257	0	0.00	227	47	17.15	85	0	0.00	51	12	19.05
KCNH5	0	genome.wustl.edu	37	14	63269300	63269300	+	Splice_Site	SNP	C	C	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	14	63269300	63269300	C	A	SNP	KCNH5	ENST00000322893	human	ensembl	74_37	-1	known	splice_site	c.1570-1	e9-1	1.000	-	-	-	no_errors	KCNH5	HGNC	ENSG00000140015	tier1	-	-	90	0	0.00	45	49	52.13	37	0	0.00	12	24	66.67
ROM1	0	genome.wustl.edu	37	11	62381818	62381818	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	11	62381818	62381818	C	T	SNP	ROM1	ENST00000278833	human	ensembl	74_37	+1	known	nonsense	c.679	p.Q227*	1.000	pfam_Tetraspanin/Peripherin,superfamily_Tetraspanin_EC2,prints_Peripherin/rom-1	pfam_Tetraspanin/Peripherin,superfamily_Tetraspanin_EC2,prints_Peripherin/rom-1	-	no_errors	ROM1	HGNC	ENSG00000149489	tier1	-	-	70	0	0.00	46	27	36.49	108	0	0.00	37	51	57.95
PTRF	0	genome.wustl.edu	37	17	40556897	40556897	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	17	40556897	40556897	C	G	SNP	PTRF	ENST00000357037	human	ensembl	74_37	-1	known	missense	c.981	p.K327N	1.000	NULL	NULL	-	no_errors	PTRF	HGNC	ENSG00000177469	tier1	-	-	57	0	0.00	25	23	47.92	25	0	0.00	15	16	51.61
GLP2R	0	genome.wustl.edu	37	17	9760880	9760880	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	17	9760880	9760880	C	G	SNP	GLP2R	ENST00000262441	human	ensembl	74_37	+1	known	missense	c.752	p.S251C	1.000	pfam_GPCR_2_secretin-like,pfscan_GPCR_2-like	pfam_GPCR_2_secretin-like,pfam_GPCR_2_extracellular_dom,smart_GPCR_2_extracellular_dom,pfscan_GPCR_2_extracellular_dom,pfscan_GPCR_2-like,prints_GPCR_2_secretin-like	-	no_errors	GLP2R	HGNC	ENSG00000065325	tier1	-	-	123	0	0.00	1235	400	24.42	120	1	0.81	809	234	22.33
GCGR	0	genome.wustl.edu	37	17	79770102	79770102	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	17	79770102	79770102	C	T	SNP	GCGR	ENST00000400723	human	ensembl	74_37	+1	known	missense	c.922	p.R308W	1.000	pfam_GPCR_2_secretin-like,pfscan_GPCR_2-like,prints_GPCR_2_secretin-like	pfam_GPCR_2_secretin-like,pfam_GPCR_2_extracellular_dom,smart_GPCR_2_extracellular_dom,pfscan_GPCR_2_extracellular_dom,pfscan_GPCR_2-like,prints_GPCR_2_glucagon_rcpt,prints_GPCR_2_secretin-like,prints_GPCR_2_GLP1/glucagon_rcpt,prints_GPCR_2_GIP_rcpt	-	no_errors	GCGR	HGNC	ENSG00000215644	tier1	-	-	148	0	0.00	76	53	41.09	72	1	1.37	18	15	45.45
ZMAT3	0	genome.wustl.edu	37	3	178785423	178785423	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	3	178785423	178785423	C	G	SNP	ZMAT3	ENST00000311417	human	ensembl	74_37	-1	known	missense	c.118	p.G40R	1.000	NULL	pfam_Znf_C2H2_jaz,smart_Znf_U1,smart_Znf_C2H2-like	-	no_errors	ZMAT3	HGNC	ENSG00000172667	tier1	-	-	184	0	0.00	63	111	63.43	59	0	0.00	13	37	74.00
ABCA13	0	genome.wustl.edu	37	7	48314977	48314977	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	7	48314977	48314977	A	T	SNP	ABCA13	ENST00000435803	human	ensembl	74_37	+1	known	missense	c.5714	p.E1905V	0.018	NULL	pfam_ABC_transporter-like,superfamily_P-loop_NTPase,smart_AAA+_ATPase,pfscan_ABC_transporter-like	-	no_errors	ABCA13	HGNC	ENSG00000179869	tier1	-	-	105	1	0.94	50	42	45.65	109	0	0.00	52	44	45.83
OR2T34	0	genome.wustl.edu	37	1	248737312	248737312	+	Silent	SNP	G	G	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	1	248737312	248737312	G	A	SNP	OR2T34	ENST00000328782	human	ensembl	74_37	-1	known	silent	c.747	p.H249	0.995	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR2T34	HGNC	ENSG00000183310	tier1	rs143585056	-	121	0	0.00	92	40	30.30	38	0	0.00	26	7	21.21
FCGBP	0	genome.wustl.edu	37	19	40421292	40421292	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	19	40421292	40421292	C	T	SNP	FCGBP	ENST00000221347	human	ensembl	74_37	-1	known	missense	c.2629	p.G877S	0.865	pfam_VWF_type-D,smart_VWF_type-D	pfam_VWF_type-D,pfam_Unchr_dom_Cys-rich,pfam_TIL_dom,superfamily_TIL_dom,smart_Fol_N,smart_VWF_type-D,smart_Unchr_dom_Cys-rich,smart_EG-like_dom,smart_VWF_C,smart_VWC_out	-	no_errors	FCGBP	HGNC	ENSG00000090920	tier1	-	-	173	0	0.00	335	86	20.38	15	0	0.00	24	6	20.00
MYH2	0	genome.wustl.edu	37	17	10432323	10432323	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	17	10432323	10432323	G	C	SNP	MYH2	ENST00000245503	human	ensembl	74_37	-1	known	missense	c.3428	p.S1143C	1.000	pfam_Myosin_tail	pfam_Myosin_tail,pfam_Myosin_head_motor_dom,pfam_Myosin_N,superfamily_P-loop_NTPase,superfamily_Prefoldin,superfamily_Ribosomal_L29,superfamily_t-SRE,smart_Myosin_head_motor_dom,smart_IQ_motif_EF-hand-BS,pfscan_IQ_motif_EF-hand-BS,prints_Myosin_head_motor_dom	-	no_errors	MYH2	HGNC	ENSG00000125414	tier1	-	-	166	0	0.00	1547	420	21.35	11	0	0.00	119	42	25.93
OR1J2	0	genome.wustl.edu	37	9	125273520	125273520	+	Missense_Mutation	SNP	T	T	C			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	9	125273520	125273520	T	C	SNP	OR1J2	ENST00000335302	human	ensembl	74_37	+1	known	missense	c.440	p.V147A	0.000	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_GPCR_Rhodpsn	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR1J2	HGNC	ENSG00000197233	tier1	-	-	187	0	0.00	69	59	46.09	108	0	0.00	32	43	57.33
MCM3AP-AS1	0	genome.wustl.edu	37	21	47669799	47669799	+	R	SNP	T	T	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	21	47669799	47669799	T	A	SNP	MCM3AP-AS1	ENST00000414659	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	MCM3AP-AS1	HGNC	ENSG00000215424	tier1	-	-	49	0	0.00	27	21	43.75	58	0	0.00	21	9	30.00
ATP5G3	0	genome.wustl.edu	37	2	176044904	176044904	+	Silent	SNP	G	G	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	2	176044904	176044904	G	T	SNP	ATP5G3	ENST00000284727	human	ensembl	74_37	-1	known	silent	c.42	p.I14	1.000	NULL	pfam_ATPase_proteolipid_c_like_dom,superfamily_ATPase_proteolipid_c_like_dom,prints_ATPase_F0-cplx_csu	-	no_errors	ATP5G3	HGNC	ENSG00000154518	tier1	-	-	114	0	0.00	107	27	20.15	61	0	0.00	37	12	24.49
LRRC8B	0	genome.wustl.edu	37	1	90050237	90050237	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	1	90050237	90050237	C	A	SNP	LRRC8B	ENST00000330947	human	ensembl	74_37	+1	known	missense	c.2028	p.F676L	1.000	smart_Leu-rich_rpt_typical-subtyp	pfam_LRR_protein-8_N,pfam_Leu-rich_rpt,smart_Leu-rich_rpt_typical-subtyp	-	no_errors	LRRC8B	HGNC	ENSG00000197147	tier1	-	-	21	0	0.00	18	13	41.94	66	0	0.00	43	24	35.82
TFAP2E	0	genome.wustl.edu	37	1	36060270	36060270	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	1	36060270	36060270	G	A	SNP	TFAP2E	ENST00000373235	human	ensembl	74_37	+1	known	missense	c.1322	p.R441Q	1.000	NULL	pfam_TF_AP2_C,prints_TF_AP2_C	-	no_errors	TFAP2E	HGNC	ENSG00000116819	tier1	-	-	59	0	0.00	31	17	35.42	132	0	0.00	46	44	48.89
HUNK	0	genome.wustl.edu	37	21	33371084	33371084	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	21	33371084	33371084	C	T	SNP	HUNK	ENST00000270112	human	ensembl	74_37	+1	known	missense	c.1732	p.H578Y	0.960	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_LipoPS_kinase,pfam_RIO-like_kinase,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	HUNK	HGNC	ENSG00000142149	tier1	-	-	91	0	0.00	35	33	48.53	62	0	0.00	29	24	45.28
NEB	0	genome.wustl.edu	37	2	152425138	152425138	+	Silent	SNP	G	G	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	2	152425138	152425138	G	A	SNP	NEB	ENST00000397345	human	ensembl	74_37	-1	known	silent	c.17628	p.L5876	0.010	pfam_Nebulin_35r-motif,smart_Nebulin_35r-motif,pfscan_Nebulin_35r-motif	pfam_Nebulin_35r-motif,pfam_SH3_domain,pfam_SH3_2,superfamily_SH3_domain,superfamily_Adhesion_dom,superfamily_6-PGluconate_DH_C-like,smart_Nebulin_35r-motif,smart_SH3_domain,pfscan_Nebulin_35r-motif,pfscan_SH3_domain,prints_Nebulin	-	no_errors	NEB	HGNC	ENSG00000183091	tier1	-	-	127	0	0.00	73	58	44.27	108	0	0.00	63	48	43.24
CUBN	0	genome.wustl.edu	37	10	16975218	16975218	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	10	16975218	16975218	C	G	SNP	CUBN	ENST00000377833	human	ensembl	74_37	-1	known	missense	c.5992	p.D1998H	0.000	pfam_CUB_dom,superfamily_CUB_dom,smart_CUB_dom,pfscan_CUB_dom	pfam_CUB_dom,pfam_EG-like_dom,pfam_EGF-like_Ca-bd_dom,superfamily_CUB_dom,superfamily_Growth_fac_rcpt_N_dom,smart_EGF-like_Ca-bd_dom,smart_EG-like_dom,smart_CUB_dom,pfscan_CUB_dom,pfscan_EG-like_dom	-	no_errors	CUBN	HGNC	ENSG00000107611	tier1	-	-	80	0	0.00	37	26	41.27	85	0	0.00	23	27	54.00
ROM1	0	genome.wustl.edu	37	11	62381831	62381831	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	11	62381831	62381831	C	T	SNP	ROM1	ENST00000534093	human	ensembl	74_37	+1	putative	nonsense	c.64	p.Q22*	1.000	NULL	NULL	-	no_errors	ROM1	HGNC	ENSG00000149489	tier1	-	-	65	0	0.00	42	21	33.33	111	0	0.00	36	48	57.14
CCDC61	0	genome.wustl.edu	37	19	46498369	46498369	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	19	46498369	46498369	G	T	SNP	CCDC61	ENST00000263284	human	ensembl	74_37	+1	known	missense	c.31	p.G11C	0.000	NULL	NULL	-	no_errors	CCDC61	HGNC	ENSG00000104983	tier1	-	-	104	1	0.95	118	43	26.71	13	0	0.00	26	6	18.75
OR8D1	0	genome.wustl.edu	37	11	124179837	124179837	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	11	124179837	124179837	C	T	SNP	OR8D1	ENST00000357821	human	ensembl	74_37	-1	known	missense	c.826	p.V276M	0.001	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_GPCR_Rhodpsn	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR8D1	HGNC	ENSG00000196341	tier1	-	-	98	0	0.00	38	30	44.12	119	1	0.83	26	26	50.00
TAS2R7	0	genome.wustl.edu	37	12	10954758	10954758	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	12	10954758	10954758	C	T	SNP	TAS2R7	ENST00000240687	human	ensembl	74_37	-1	known	missense	c.412	p.V138M	0.000	pfam_TAS2_rcpt,pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_TAS2_rcpt,pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	-	no_errors	TAS2R7	HGNC	ENSG00000121377	tier1	-	-	109	0	0.00	105	49	31.82	134	0	0.00	144	70	32.71
HERC2P4	0	genome.wustl.edu	37	16	32191961	32191961	+	R	SNP	G	G	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	16	32191961	32191961	G	T	SNP	HERC2P4	ENST00000566591	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.996	-	-	-	no_errors	HERC2P4	HGNC	ENSG00000230267	tier1	-	-	349	1	0.29	199	56	21.96	105	0	0.00	69	42	37.84
HNF4A	0	genome.wustl.edu	37	20	43030126	43030126	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	T	T	T	-	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	20	43030126	43030126	T	-	DEL	HNF4A	ENST00000316099	human	ensembl	74_37	+1	known	frame_shift_del	c.114	p.N38fs	1.000	NULL	pfam_Nucl_hrmn_rcpt_lig-bd_core,pfam_Znf_hrmn_rcpt,superfamily_Nucl_hormone_rcpt_ligand-bd,smart_Znf_hrmn_rcpt,smart_Nucl_hrmn_rcpt_lig-bd_core,pfscan_Znf_hrmn_rcpt,prints_Str_hrmn_rcpt,prints_Znf_hrmn_rcpt,prints_COUP_TF,prints_Retinoid-X_rcpt/HNF4	-	no_errors	HNF4A	HGNC	ENSG00000101076	tier1			138	0	0.00	81	53	39.55	60	0	0.00	31	22	41.51
ACSS2	0	genome.wustl.edu	37	20	33464462	33464462	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	20	33464462	33464462	A	T	SNP	ACSS2	ENST00000253382	human	ensembl	74_37	+1	known	missense	c.14	p.E5V	0.996	NULL	pfam_AMP-dep_Synth/Lig	-	no_errors	ACSS2	HGNC	ENSG00000131069	tier1	-	-	19	0	0.00	17	8	30.77	8	0	0.00	8	6	42.86
ANGPTL2	0	genome.wustl.edu	37	9	129870420	129870420	+	Silent	SNP	G	G	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	9	129870420	129870420	G	A	SNP	ANGPTL2	ENST00000373425	human	ensembl	74_37	-1	known	silent	c.591	p.I197	0.077	NULL	pfam_Fibrinogen_a/b/g_C_dom,superfamily_Fibrinogen_a/b/g_C_dom,smart_Fibrinogen_a/b/g_C_dom	-	no_errors	ANGPTL2	HGNC	ENSG00000136859	tier1	-	-	53	0	0.00	24	31	56.36	11	0	0.00	6	2	25.00
AP2A1	0	genome.wustl.edu	37	19	50308789	50308789	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	19	50308789	50308789	C	A	SNP	AP2A1	ENST00000354293	human	ensembl	74_37	+1	known	nonsense	c.2424	p.C808*	0.988	pfam_Clathrin_a/b/g-adaptin_app_Ig,superfamily_Coatomer/clathrin_app_Ig-like,smart_Clathrin_a/b/g-adaptin_app_Ig,pirsf_AP2_complex_asu	pfam_Clathrin/coatomer_adapt-like_N,pfam_Clathrin_a-adaptin_app_sub_C,pfam_Clathrin_a/b/g-adaptin_app_Ig,superfamily_ARM-type_fold,superfamily_Coatomer/calthrin_app_sub_C,superfamily_Coatomer/clathrin_app_Ig-like,smart_Clathrin_a/b/g-adaptin_app_Ig,pirsf_AP2_complex_asu	-	no_errors	AP2A1	HGNC	ENSG00000196961	tier1	-	-	60	0	0.00	40	46	53.49	9	0	0.00	1	7	87.50
CC2D1A	0	genome.wustl.edu	37	19	14024037	14024037	+	Silent	SNP	G	G	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	19	14024037	14024037	G	A	SNP	CC2D1A	ENST00000318003	human	ensembl	74_37	+1	known	silent	c.435	p.A145	0.098	smart_DM14	pfam_C2_dom,superfamily_C2_dom,smart_DM14,smart_C2_dom	-	no_errors	CC2D1A	HGNC	ENSG00000132024	tier1	-	-	85	0	0.00	58	41	41.41	17	0	0.00	4	13	76.47
CDH8	0	genome.wustl.edu	37	16	61891134	61891134	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	16	61891134	61891134	C	A	SNP	CDH8	ENST00000577390	human	ensembl	74_37	-1	known	missense	c.556	p.V186F	1.000	pfam_Cadherin,superfamily_Cadherin-like,pfscan_Cadherin,prints_Cadherin	pfam_Cadherin,pfam_Cadherin_cytoplasmic-dom,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin	-	no_errors	CDH8	HGNC	ENSG00000150394	tier1	-	-	71	0	0.00	5	39	88.64	52	0	0.00	2	22	91.67
FDPS	0	genome.wustl.edu	37	1	155290334	155290342	+	In_Frame_Del	DEL	CGCAGCACC	CGCAGCACC	-			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	CGCAGCACC	CGCAGCACC	CGCAGCACC	-	CGCAGCACC	CGCAGCACC	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	1	155290334	155290342	CGCAGCACC	-	DEL	FDPS	ENST00000356657	human	ensembl	74_37	+1	known	in_frame_del	c.1194_1202	p.AAP399in_frame_del	0.862:0.905:0.903:0.002:0.000:0.001:0.001:0.936:0.989	superfamily_Terpenoid_synth	pfam_Polyprenyl_synt,superfamily_Terpenoid_synth	-	no_errors	FDPS	HGNC	ENSG00000160752	tier1			16	0	0.00	7	2	22.22	16	0	0.00	7	2	22.22
LENG8	0	genome.wustl.edu	37	19	54965619	54965619	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	19	54965619	54965619	C	G	SNP	LENG8	ENST00000326764	human	ensembl	74_37	+1	known	missense	c.437	p.P146R	1.000	NULL	pfam_SAC3/GANP/Nin1/mts3/eIF-3-p25	-	no_errors	LENG8	HGNC	ENSG00000167615	tier1	-	-	128	0	0.00	61	55	47.01	11	0	0.00	4	11	73.33
MICA	0	genome.wustl.edu	37	6	31378924	31378924	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	6	31378924	31378924	A	G	SNP	MICA	ENST00000449934	human	ensembl	74_37	+1	known	missense	c.401	p.Y134C	0.000	pfam_MHC_I_a_a1/a2,superfamily_MHC_I/II-like_Ag-recog	pfam_MHC_I_a_a1/a2,pfam_Ig_C1-set,superfamily_MHC_I/II-like_Ag-recog,smart_Ig_C1-set,pfscan_Ig-like_dom	-	no_errors	MICA	HGNC	ENSG00000204520	tier1	-	-	56	0	0.00	32	29	46.77	21	0	0.00	2	14	87.50
PAK3	0	genome.wustl.edu	37	X	110390987	110390987	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	X	110390987	110390987	G	A	SNP	PAK3	ENST00000360648	human	ensembl	74_37	+1	known	missense	c.407	p.R136Q	1.000	pfam_CRIB_dom	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_CRIB_dom,superfamily_Kinase-like_dom,smart_CRIB_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_CRIB_dom,pfscan_Prot_kinase_dom	-	no_errors	PAK3	HGNC	ENSG00000077264	tier1	-	-	45	0	0.00	3	38	92.68	95	0	0.00	8	66	89.19
RIPK4	0	genome.wustl.edu	37	21	43161030	43161030	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	21	43161030	43161030	C	T	SNP	RIPK4	ENST00000352483	human	ensembl	74_37	-1	known	missense	c.2467	p.A823T	0.000	NULL	pfam_Ankyrin_rpt,pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Ankyrin_rpt-contain_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,pfscan_Prot_kinase_dom,prints_Ankyrin_rpt,prints_Ser-Thr/Tyr_kinase_cat_dom	-	no_errors	RIPK4	HGNC	ENSG00000183421	tier1	rs142879262	-	150	0	0.00	75	62	44.93	12	0	0.00	4	7	63.64
ZC3H18	0	genome.wustl.edu	37	16	88677733	88677744	+	In_Frame_Del	DEL	GAGCGGGACCGA	GAGCGGGACCGA	-			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	GAGCGGGACCGA	GAGCGGGACCGA					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	16	88677733	88677744	GAGCGGGACCGA	-	DEL	ZC3H18	ENST00000301011	human	ensembl	74_37	+1	known	in_frame_del	c.1264_1275	p.DRER424in_frame_del	0.989:1.000:1.000:1.000:1.000:0.998:1.000:1.000:0.992:0.997:0.991:0.721	NULL	smart_Znf_CCCH	-	no_errors	ZC3H18	HGNC	ENSG00000158545	tier1			20	0	0.00	0	1	100.00	20	0	0.00	0	1	100.00
RYR1	0	genome.wustl.edu	37	19	38964203	38964203	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	19	38964203	38964203	G	A	SNP	RYR1	ENST00000359596	human	ensembl	74_37	+1	known	missense	c.3952	p.A1318T	0.013	NULL	pfam_Ca-rel_channel,pfam_Ryanodine_rcpt,pfam_Ryanrecept_TM4-6,pfam_SPRY_rcpt,pfam_Ins145_P3_rcpt,pfam_MIR_motif,pfam_RIH_assoc-dom,pfam_Ion_trans_dom,superfamily_MIR_motif,superfamily_ConA-like_lec_gl_sf,superfamily_MG_RAP_rcpt_1,smart_MIR_motif,smart_SPla/RYanodine_receptor_subgr,prints_Ryan_recept,pfscan_B30.2/SPRY,pfscan_MIR_motif	-	no_errors	RYR1	HGNC	ENSG00000196218	tier1	-	-	85	0	0.00	160	51	24.06	0	0	0.00	0	0	0.00
SPPL2B	0	genome.wustl.edu	37	19	2341094	2341101	+	R	DEL	CTCCCTGG	CTCCCTGG	-			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	CTCCCTGG	CTCCCTGG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	19	2341094	2341101	CTCCCTGG	-	DEL	SPPL2B	ENST00000592738	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000:0.000:0.010:0.001:0.000:0.000:0.001:0.000	-	-	-	no_errors	SPPL2B	HGNC	ENSG00000005206	tier1			0	0	0.00	1	0	0.00	0	0	0.00	1	0	0.00
DAPL1	0	genome.wustl.edu	37	2	159710125	159710125	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	2	159710125	159710125	C	A	SNP	DAPL1	ENST00000409042	human	ensembl	74_37	+1	putative	missense	c.319	p.P107T	0.834	NULL	NULL	-	no_errors	DAPL1	HGNC	ENSG00000163331	tier1	-	-	119	0	0.00	71	67	48.55	0	0	0.00	0	3	100.00
TREML1	0	genome.wustl.edu	37	6	41121641	41121641	+	Silent	SNP	C	C	T			TCGA-DX-A48R-01A-11D-A307-09	TCGA-DX-A48R-10A-01D-A307-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	09bcb1b5-568d-4ec4-99a2-5401f231aae8	ab74d2ac-412f-4c3a-988e-920595b8fcc1	6	41121641	41121641	C	T	SNP	TREML1	ENST00000426005	human	ensembl	74_37	-1	known	silent	c.231	p.T77	0.000	pfam_Ig_V-set	pfam_Ig_V-set	-	no_errors	TREML1	HGNC	ENSG00000161911	tier1	rs201231028	-	156	0	0.00	115	23	16.67	38	0	0.00	27	2	6.90