Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
DSCAM	0	genome.wustl.edu	37	21	41416026	41416026	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	21	41416026	41416026	C	T	SNP	DSCAM	ENST00000400454	human	ensembl	74_37	-1	known	missense	c.5362	p.V1788I	1.000	NULL	pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Immunoglobulin,pfam_Ig_V-set,superfamily_Fibronectin_type3,smart_Ig_sub2,smart_Ig_sub,smart_Ig_V-set_subgr,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	DSCAM	HGNC	ENSG00000171587	tier1	-	-	25	0	0.00	17	16	48.48	57	0	0.00	36	51	58.62
TMEM131	0	genome.wustl.edu	37	2	98428883	98428883	+	Splice_Site	SNP	C	C	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	2	98428883	98428883	C	A	SNP	TMEM131	ENST00000186436	human	ensembl	74_37	-1	known	splice_site	c.1863+1	e17+1	1.000	-	-	-	no_errors	TMEM131	HGNC	ENSG00000075568	tier1	-	-	48	0	0.00	39	66	62.86	87	0	0.00	69	81	53.64
FSTL4	0	genome.wustl.edu	37	5	132902896	132902896	+	Silent	SNP	A	A	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	5	132902896	132902896	A	G	SNP	FSTL4	ENST00000265342	human	ensembl	74_37	-1	known	silent	c.141	p.F47	1.000	NULL	pfam_Ig_I-set,pfam_Immunoglobulin,pfam_Kazal_dom,smart_Kazal_dom,smart_Ig_sub,smart_Ig_sub2,pfscan_EF_hand_dom,pfscan_Ig-like_dom	-	no_errors	FSTL4	HGNC	ENSG00000053108	tier1	-	-	56	0	0.00	58	12	17.14	99	0	0.00	95	27	22.13
ZNF80	0	genome.wustl.edu	37	3	113955795	113955795	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	3	113955795	113955795	C	T	SNP	ZNF80	ENST00000308095	human	ensembl	74_37	-1	known	missense	c.127	p.V43I	0.002	NULL	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	ZNF80	HGNC	ENSG00000174255	tier1	-	-	52	0	0.00	71	15	17.44	101	0	0.00	178	39	17.89
IGSF1	0	genome.wustl.edu	37	X	130408685	130408685	+	Silent	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	130408685	130408685	G	A	SNP	IGSF1	ENST00000370903	human	ensembl	74_37	-1	known	silent	c.3654	p.I1218	0.983	smart_Ig_sub,smart_Ig_sub2	pfam_Immunoglobulin,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	-	no_errors	IGSF1	HGNC	ENSG00000147255	tier1	-	-	42	0	0.00	80	10	11.11	107	0	0.00	200	24	10.71
PTPRT	0	genome.wustl.edu	37	20	41419840	41419840	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	20	41419840	41419840	A	G	SNP	PTPRT	ENST00000373198	human	ensembl	74_37	-1	known	missense	c.481	p.Y161H	1.000	pfam_MAM_dom,superfamily_ConA-like_lec_gl_sf,smart_MAM_dom,pfscan_MAM_dom,prints_MAM_dom	pfam_Tyr_Pase_rcpt/non-rcpt,pfam_MAM_dom,pfam_Fibronectin_type3,superfamily_ConA-like_lec_gl_sf,superfamily_Fibronectin_type3,smart_MAM_dom,smart_Fibronectin_type3,smart_Tyr_Pase_rcpt/non-rcpt,smart_Tyr_Pase_cat,pfscan_Fibronectin_type3,pfscan_MAM_dom,pfscan_Tyr/Dual-sp_Pase,pfscan_Tyr_Pase_rcpt/non-rcpt,pfscan_Ig-like_dom,prints_Tyr_Pase_rcpt/non-rcpt,prints_MAM_dom	-	no_errors	PTPRT	HGNC	ENSG00000196090	tier1	-	-	76	0	0.00	84	25	22.94	65	0	0.00	113	31	21.53
MTHFD2L	0	genome.wustl.edu	37	4	75041117	75041117	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	4	75041117	75041117	C	T	SNP	MTHFD2L	ENST00000395759	human	ensembl	74_37	+1	known	missense	c.448	p.P150S	1.000	pfam_THF_DH/CycHdrlase_cat_dom,prints_THF_DH/CycHdrlase	pfam_THF_DH/CycHdrlase_D-bd_dom,pfam_THF_DH/CycHdrlase_cat_dom,prints_THF_DH/CycHdrlase	-	no_errors	MTHFD2L	HGNC	ENSG00000163738	tier1	-	-	74	0	0.00	134	36	21.18	133	0	0.00	202	42	17.21
CCDC117	0	genome.wustl.edu	37	22	29169758	29169758	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	22	29169758	29169758	G	C	SNP	CCDC117	ENST00000249064	human	ensembl	74_37	+1	known	missense	c.231	p.E77D	0.860	NULL	NULL	-	no_errors	CCDC117	HGNC	ENSG00000159873	tier1	-	-	65	0	0.00	35	20	36.36	143	0	0.00	108	36	25.00
PGLYRP3	0	genome.wustl.edu	37	1	153271624	153271624	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	1	153271624	153271624	A	G	SNP	PGLYRP3	ENST00000290722	human	ensembl	74_37	-1	known	missense	c.812	p.I271T	0.995	pfam_Amidase_domain,superfamily_Amidase_domain,smart_PGRP_domain_met/bac,smart_Amidase_domain	pfam_Amidase_domain,superfamily_Amidase_domain,smart_PGRP_domain_met/bac,smart_Amidase_domain	-	no_errors	PGLYRP3	HGNC	ENSG00000159527	tier1	-	-	53	0	0.00	41	16	28.07	89	0	0.00	101	32	24.06
DMTF1	0	genome.wustl.edu	37	7	86811368	86811368	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	7	86811368	86811368	A	G	SNP	DMTF1	ENST00000394702	human	ensembl	74_37	+1	known	missense	c.746	p.H249R	1.000	NULL	NULL	-	no_errors	DMTF1	HGNC	ENSG00000135164	tier1	-	-	69	0	0.00	36	23	38.98	82	0	0.00	65	50	43.48
TRIM21	0	genome.wustl.edu	37	11	4407544	4407544	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	11	4407544	4407544	C	T	SNP	TRIM21	ENST00000543625	human	ensembl	74_37	-1	known	missense	c.745	p.V249M	0.000	NULL	pfam_SPRY_rcpt,pfam_Znf_B-box,pfam_Znf_C3HC4_RING-type,superfamily_ConA-like_lec_gl_sf,smart_Ubox_domain,smart_Znf_RING,smart_Znf_B-box,smart_PRY,smart_SPla/RYanodine_receptor_subgr,pfscan_B30.2/SPRY,pfscan_Znf_B-box,pfscan_Znf_RING,prints_Butyrophylin,prints_Znf_B-box_chordata	-	no_errors	TRIM21	HGNC	ENSG00000132109	tier1	-	-	23	0	0.00	8	17	65.38	86	0	0.00	35	62	63.27
ZNF300	0	genome.wustl.edu	37	5	150282891	150282891	+	Silent	SNP	A	A	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	5	150282891	150282891	A	G	SNP	ZNF300	ENST00000446148	human	ensembl	74_37	-1	known	silent	c.21	p.S7	0.001	NULL	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF300	HGNC	ENSG00000145908	tier1	-	-	61	0	0.00	94	22	18.97	99	0	0.00	141	38	21.23
ESX1	0	genome.wustl.edu	37	X	103494923	103494923	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	103494923	103494923	A	T	SNP	ESX1	ENST00000372588	human	ensembl	74_37	-1	known	missense	c.1207	p.C403S	0.000	NULL	pfam_Homeobox_dom,superfamily_Homeodomain-like,smart_Homeobox_dom,pfscan_Homeobox_dom,prints_POU	-	no_errors	ESX1	HGNC	ENSG00000123576	tier1	-	-	133	0	0.00	103	33	24.26	109	0	0.00	103	23	18.11
NEFH	0	genome.wustl.edu	37	22	29885939	29885939	+	Silent	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	22	29885939	29885939	G	A	SNP	NEFH	ENST00000310624	human	ensembl	74_37	+1	known	silent	c.2310	p.A770	0.004	NULL	pfam_IF,pfam_DUF1388	-	no_errors	NEFH	HGNC	ENSG00000100285	tier1	-	-	89	0	0.00	51	16	23.88	52	0	0.00	28	21	42.86
ZNF727	0	genome.wustl.edu	37	7	63538202	63538202	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	7	63538202	63538202	G	A	SNP	ZNF727	ENST00000550760	human	ensembl	74_37	+1	known	missense	c.775	p.E259K	0.400	smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF727	HGNC	ENSG00000257482	tier1	rs192720590	GMAF=0.0005	44	0	0.00	34	44	56.41	21	0	0.00	19	18	48.65
CSF2RB	0	genome.wustl.edu	37	22	37334065	37334065	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	22	37334065	37334065	G	C	SNP	CSF2RB	ENST00000262825	human	ensembl	74_37	+1	known	missense	c.2233	p.D745H	0.001	pirsf_IL3_rcpt_beta	pirsf_IL3_rcpt_beta,pfam_Fibronectin_type3,pfam_IL-6_rcpt_alpha-bd,pfam_Interferon_alpha/beta_rcpt_bsu,superfamily_Fibronectin_type3,smart_Fibronectin_type3,pfscan_Fibronectin_type3	-	no_errors	CSF2RB	HGNC	ENSG00000100368	tier1	-	-	30	0	0.00	32	102	75.56	70	0	0.00	74	172	69.92
ARHGAP27	0	genome.wustl.edu	37	17	43472839	43472839	+	Missense_Mutation	SNP	T	T	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	17	43472839	43472839	T	G	SNP	ARHGAP27	ENST00000428638	human	ensembl	74_37	-1	known	missense	c.2653	p.I885L	1.000	superfamily_Rho_GTPase_activation_prot,pfscan_RhoGAP_dom	pfam_RhoGAP_dom,pfam_WW_dom,pfam_Pleckstrin_homology,superfamily_Rho_GTPase_activation_prot,superfamily_SH3_domain,superfamily_WW_dom,smart_WW_dom,smart_Pleckstrin_homology,smart_RhoGAP_dom,pfscan_Pleckstrin_homology,pfscan_SH3_domain,pfscan_WW_dom,pfscan_RhoGAP_dom	-	no_errors	ARHGAP27	HGNC	ENSG00000159314	tier1	-	-	29	0	0.00	18	16	45.71	11	0	0.00	17	6	26.09
TMEM169	0	genome.wustl.edu	37	2	216965176	216965176	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	2	216965176	216965176	A	T	SNP	TMEM169	ENST00000295658	human	ensembl	74_37	+1	known	missense	c.805	p.S269C	1.000	NULL	NULL	-	no_errors	TMEM169	HGNC	ENSG00000163449	tier1	-	-	31	0	0.00	10	11	52.38	64	0	0.00	21	49	70.00
LCT	0	genome.wustl.edu	37	2	136570168	136570168	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	2	136570168	136570168	C	T	SNP	LCT	ENST00000264162	human	ensembl	74_37	-1	known	missense	c.2066	p.R689H	1.000	pfam_Glyco_hydro_1,superfamily_Glycoside_hydrolase_SF,prints_Glyco_hydro_1	pfam_Glyco_hydro_1,superfamily_Glycoside_hydrolase_SF,prints_Glyco_hydro_1	-	no_errors	LCT	HGNC	ENSG00000115850	tier1	rs146706415	GMAF=0.0005	33	0	0.00	9	18	64.29	76	0	0.00	17	61	78.21
RIMS2	0	genome.wustl.edu	37	8	105235954	105235954	+	Silent	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	8	105235954	105235954	G	T	SNP	RIMS2	ENST00000339750	human	ensembl	74_37	+1	known	silent	c.75	p.L25	0.970	NULL	pfam_C2_dom,superfamily_C2_dom,smart_C2_dom,pfscan_C2_dom	-	no_errors	RIMS2	HGNC	ENSG00000176406	tier1	-	-	71	0	0.00	33	18	35.29	22	0	0.00	17	8	32.00
ZNF225	0	genome.wustl.edu	37	19	44622637	44622637	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	19	44622637	44622637	C	T	SNP	ZNF225	ENST00000262894	human	ensembl	74_37	+1	known	missense	c.145	p.H49Y	0.002	superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,pfscan_Krueppel-associated_box	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF225	HGNC	ENSG00000256294	tier1	-	-	90	0	0.00	44	12	21.43	57	0	0.00	85	24	22.02
IGSF1	0	genome.wustl.edu	37	X	130408744	130408744	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	130408744	130408744	G	C	SNP	IGSF1	ENST00000370903	human	ensembl	74_37	-1	known	missense	c.3595	p.L1199V	0.994	smart_Ig_sub,smart_Ig_sub2	pfam_Immunoglobulin,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	-	no_errors	IGSF1	HGNC	ENSG00000147255	tier1	-	-	81	0	0.00	93	11	10.58	131	0	0.00	208	31	12.97
DCX	0	genome.wustl.edu	37	X	110653472	110653472	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	110653472	110653472	G	T	SNP	DCX	ENST00000338081	human	ensembl	74_37	-1	known	missense	c.398	p.A133D	1.000	smart_Doublecortin_dom,pirsf_Doublecortin_chordata	pfam_Doublecortin_dom,smart_Doublecortin_dom,pirsf_Doublecortin_chordata,pfscan_Doublecortin_dom	-	no_errors	DCX	HGNC	ENSG00000077279	tier1	-	-	75	0	0.00	54	18	25.00	82	0	0.00	110	30	21.43
ZNF534	0	genome.wustl.edu	37	19	52954520	52954520	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	19	52954520	52954520	G	A	SNP	ZNF534	ENST00000301085	human	ensembl	74_37	+1	putative	missense	c.352	p.G118S	0.001	NULL	pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,pfscan_Krueppel-associated_box	-	no_errors	ZNF534	HGNC	ENSG00000198633	tier1	-	-	73	0	0.00	94	19	16.81	36	0	0.00	56	8	12.50
ASPDH	0	genome.wustl.edu	37	19	51017057	51017057	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	19	51017057	51017057	C	A	SNP	ASPDH	ENST00000389208	human	ensembl	74_37	-1	known	missense	c.24	p.R8S	0.806	NULL	pfam_Asp_DH,pfam_Asp/hSer_DH_D-bd	-	no_errors	ASPDH	HGNC	ENSG00000204653	tier1	-	-	85	0	0.00	105	19	15.32	35	0	0.00	62	20	24.39
SNRPB	0	genome.wustl.edu	37	20	2442576	2442576	+	Silent	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	20	2442576	2442576	C	T	SNP	SNRPB	ENST00000381342	human	ensembl	74_37	-1	known	silent	c.695	p.*232	1.000	NULL	pfam_Ribonucl_LSM,superfamily_LSM_dom,smart_Ribonucl_LSM_euk/arc,pirsf_snRNP-assoc_SmB/SmN	-	no_errors	SNRPB	HGNC	ENSG00000125835	tier1	-	-	67	0	0.00	81	21	20.59	134	0	0.00	113	34	23.13
PKD2L2	0	genome.wustl.edu	37	5	137226243	137226243	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	5	137226243	137226243	C	A	SNP	PKD2L2	ENST00000508883	human	ensembl	74_37	+1	known	nonsense	c.105	p.Y35*	1.000	NULL	pfam_PKD1_2_channel,pfam_Ion_trans_dom,prints_PKD_2	-	no_errors	PKD2L2	HGNC	ENSG00000078795	tier1	-	-	103	1	0.95	122	42	25.61	90	0	0.00	121	43	26.22
FAM155A	0	genome.wustl.edu	37	13	107822972	107822972	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	13	107822972	107822972	A	T	SNP	FAM155A	ENST00000375915	human	ensembl	74_37	-1	known	missense	c.1250	p.L417H	1.000	NULL	NULL	-	no_errors	FAM155A	HGNC	ENSG00000204442	tier1	-	-	57	0	0.00	29	8	21.62	41	0	0.00	41	19	31.67
ANO7	0	genome.wustl.edu	37	2	242149951	242149951	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	2	242149951	242149951	C	G	SNP	ANO7	ENST00000274979	human	ensembl	74_37	+1	known	missense	c.1689	p.I563M	0.998	pfam_Anoctamin	pfam_Anoctamin	-	no_errors	ANO7	HGNC	ENSG00000146205	tier1	-	-	20	0	0.00	10	11	52.38	69	0	0.00	26	42	61.76
GBF1	0	genome.wustl.edu	37	10	104121645	104121645	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	10	104121645	104121645	G	C	SNP	GBF1	ENST00000369983	human	ensembl	74_37	+1	known	missense	c.1659	p.E553D	0.984	superfamily_ARM-type_fold	pfam_Sec7_dom,superfamily_Sec7_dom,superfamily_ARM-type_fold,smart_Sec7_dom,pfscan_Sec7_dom	-	no_errors	GBF1	HGNC	ENSG00000107862	tier1	-	-	18	0	0.00	9	17	65.38	56	0	0.00	45	21	31.82
RANGAP1	0	genome.wustl.edu	37	22	41642614	41642614	+	Missense_Mutation	SNP	T	T	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	22	41642614	41642614	T	C	SNP	RANGAP1	ENST00000356244	human	ensembl	74_37	-1	known	missense	c.1757	p.K586R	0.721	pfam_Ran_GTPase_activating_1_C,superfamily_Ran_GTPase_activating_1_C	pfam_Ran_GTPase_activating_1_C,superfamily_Ran_GTPase_activating_1_C,smart_Leu-rich_rpt_RNase_inh_sub-typ	-	no_errors	RANGAP1	HGNC	ENSG00000100401	tier1	-	-	55	0	0.00	39	12	23.53	59	0	0.00	125	18	12.59
STC1	0	genome.wustl.edu	37	8	23702549	23702549	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	8	23702549	23702549	A	T	SNP	STC1	ENST00000290271	human	ensembl	74_37	-1	known	missense	c.478	p.Y160N	1.000	pfam_Stanniocalcin	pfam_Stanniocalcin	-	no_errors	STC1	HGNC	ENSG00000159167	tier1	-	-	31	0	0.00	8	10	55.56	30	0	0.00	30	35	53.85
KRTAP24-1	0	genome.wustl.edu	37	21	31654526	31654526	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	21	31654526	31654526	C	T	SNP	KRTAP24-1	ENST00000340345	human	ensembl	74_37	-1	known	missense	c.725	p.R242K	1.000	NULL	pfam_KRTAP_PMG	-	no_errors	KRTAP24-1	HGNC	ENSG00000188694	tier1	-	-	45	0	0.00	33	6	15.38	97	0	0.00	101	33	24.63
FAM90A27P	0	genome.wustl.edu	37	19	53786084	53786084	+	R	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	19	53786084	53786084	G	T	SNP	FAM90A27P	ENST00000599085	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	FAM90A27P	HGNC	ENSG00000189348	tier1	-	-	84	0	0.00	82	23	21.90	13	0	0.00	13	9	40.91
CD209	0	genome.wustl.edu	37	19	7808042	7808042	+	Silent	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	19	7808042	7808042	G	A	SNP	CD209	ENST00000315599	human	ensembl	74_37	-1	known	silent	c.1098	p.D366	0.003	pfam_C-type_lectin,superfamily_C-type_lectin_fold,smart_C-type_lectin,pfscan_C-type_lectin,prints_AntifreezeII	pfam_C-type_lectin,superfamily_C-type_lectin_fold,smart_C-type_lectin,pfscan_C-type_lectin,prints_AntifreezeII	-	no_errors	CD209	HGNC	ENSG00000090659	tier1	-	-	85	0	0.00	44	46	51.11	93	0	0.00	79	64	44.44
MYH13	0	genome.wustl.edu	37	17	10248638	10248638	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	17	10248638	10248638	G	C	SNP	MYH13	ENST00000252172	human	ensembl	74_37	-1	known	missense	c.1465	p.Q489E	1.000	pfam_Myosin_head_motor_dom,superfamily_P-loop_NTPase,smart_Myosin_head_motor_dom	pfam_Myosin_tail,pfam_Myosin_head_motor_dom,pfam_Myosin_N,superfamily_P-loop_NTPase,superfamily_Prefoldin,smart_Myosin_head_motor_dom,pfscan_IQ_motif_EF-hand-BS,prints_Myosin_head_motor_dom	-	no_errors	MYH13	HGNC	ENSG00000006788	tier1	-	-	154	0	0.00	287	35	10.87	28	0	0.00	48	11	18.33
HKDC1	0	genome.wustl.edu	37	10	70980216	70980216	+	Missense_Mutation	SNP	T	T	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	10	70980216	70980216	T	C	SNP	HKDC1	ENST00000354624	human	ensembl	74_37	+1	known	missense	c.25	p.F9L	0.997	NULL	pfam_Hexokinase_C,pfam_Hexokinase_N,prints_Hexokinase	-	no_errors	HKDC1	HGNC	ENSG00000156510	tier1	-	-	58	0	0.00	15	30	66.67	106	0	0.00	22	69	75.82
DGAT1	0	genome.wustl.edu	37	8	145541664	145541664	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	8	145541664	145541664	G	C	SNP	DGAT1	ENST00000531896	human	ensembl	74_37	-1	putative	missense	c.859	p.L287V	0.929	NULL	superfamily_PEP-util_enz_mobile_dom	-	no_errors	DGAT1	HGNC	ENSG00000185000	tier1	-	-	19	0	0.00	11	5	31.25	30	0	0.00	33	9	21.43
NSUN5	0	genome.wustl.edu	37	7	72717521	72717521	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	7	72717521	72717521	G	A	SNP	NSUN5	ENST00000438747	human	ensembl	74_37	-1	known	missense	c.1292	p.A431V	0.027	NULL	pfam_Fmu/NOL1/Nop2p,prints_RCMT	-	no_errors	NSUN5	HGNC	ENSG00000130305	tier1	-	-	90	0	0.00	77	13	14.44	38	0	0.00	66	25	27.47
ZMAT1	0	genome.wustl.edu	37	X	101159271	101159271	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	101159271	101159271	G	T	SNP	ZMAT1	ENST00000372782	human	ensembl	74_37	-1	known	missense	c.154	p.L52I	0.052	NULL	superfamily_Asn/Gln_tR_amidoTrfrase-rel,smart_Znf_U1,smart_Znf_C2H2-like	-	no_errors	ZMAT1	HGNC	ENSG00000166432	tier1	-	-	48	0	0.00	51	21	29.17	124	0	0.00	130	39	23.08
SRPK2	0	genome.wustl.edu	37	7	104758460	104758460	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	7	104758460	104758460	C	T	SNP	SRPK2	ENST00000393651	human	ensembl	74_37	-1	known	missense	c.1925	p.R642Q	1.000	pfam_Prot_kinase_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,pfscan_Prot_kinase_dom	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	SRPK2	HGNC	ENSG00000135250	tier1	-	-	28	0	0.00	39	19	32.76	131	0	0.00	102	74	42.05
VPS4A	0	genome.wustl.edu	37	16	69353364	69353364	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	16	69353364	69353364	G	A	SNP	VPS4A	ENST00000254950	human	ensembl	74_37	+1	known	missense	c.538	p.V180M	1.000	pfam_ATPase_AAA_core,pfam_IstB_ATP-bd,pfam_ATPase_dyneun-rel_AAA,pfam_D_helicase_Holl-junc_RuvB_N,superfamily_P-loop_NTPase,smart_AAA+_ATPase	pfam_ATPase_AAA_core,pfam_Vps4_C,pfam_MIT,pfam_IstB_ATP-bd,pfam_ATPase_dyneun-rel_AAA,pfam_D_helicase_Holl-junc_RuvB_N,superfamily_P-loop_NTPase,smart_MIT,smart_AAA+_ATPase	-	no_errors	VPS4A	HGNC	ENSG00000132612	tier1	-	-	65	0	0.00	22	15	40.54	71	0	0.00	69	27	28.12
MLH1	0	genome.wustl.edu	37	3	37070375	37070375	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	3	37070375	37070375	A	T	SNP	MLH1	ENST00000231790	human	ensembl	74_37	+1	known	missense	c.1510	p.T504S	1.000	NULL	pfam_D_mismatch_repair_C,pfam_HATPase_ATP-bd,superfamily_HATPase_ATP-bd,superfamily_Ribosomal_S5_D2-typ_fold,tigrfam_D_mismatch_repair_N	-	no_errors	MLH1	HGNC	ENSG00000076242	tier1	-	-	108	0	0.00	29	59	67.05	119	0	0.00	34	66	65.35
CNTP4	0	genome.wustl.edu	37	16	76513331	76513331	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	16	76513331	76513331	C	T	SNP	CNTP4	ENST00000307431	human	ensembl	74_37	+1	known	missense	c.1775	p.S592L	1.000	superfamily_Fibrinogen_a/b/g_C_dom	pfam_Laminin_G,pfam_Coagulation_fac_5/8-C_type_dom,superfamily_Galactose-bd-like,superfamily_ConA-like_lec_gl_sf,superfamily_Fibrinogen_a/b/g_C_dom,smart_Coagulation_fac_5/8-C_type_dom,smart_Laminin_G,smart_EG-like_dom,pfscan_EG-like_dom,pfscan_Coagulation_fac_5/8-C_type_dom,pfscan_Laminin_G	-	no_errors	CNTP4	HGNC	ENSG00000152910	tier1	-	-	60	0	0.00	41	20	32.79	87	0	0.00	65	28	30.11
PTAFR	0	genome.wustl.edu	37	1	28503185	28503185	+	Splice_Site	SNP	C	C	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	1	28503185	28503185	C	G	SNP	PTAFR	ENST00000539896	human	ensembl	74_37	-1	known	splice_site	c.1-1	e1-1	0.930	-	-	-	no_errors	PTAFR	HGNC	ENSG00000169403	tier1	-	-	42	0	0.00	53	21	28.38	54	0	0.00	67	58	46.40
FAM83B	0	genome.wustl.edu	37	6	54805724	54805724	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	6	54805724	54805724	A	G	SNP	FAM83B	ENST00000306858	human	ensembl	74_37	+1	known	missense	c.1955	p.K652R	0.089	NULL	pfam_DUF1669	-	no_errors	FAM83B	HGNC	ENSG00000168143	tier1	-	-	61	0	0.00	51	16	23.88	97	0	0.00	111	29	20.71
CTCFL	0	genome.wustl.edu	37	20	56090832	56090832	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	20	56090832	56090832	C	A	SNP	CTCFL	ENST00000423479	human	ensembl	74_37	-1	known	missense	c.1118	p.C373F	0.001	smart_Znf_C2H2-like,pfscan_Znf_C2H2	smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	CTCFL	HGNC	ENSG00000124092	tier1	-	-	64	0	0.00	55	30	35.29	81	0	0.00	77	86	52.44
GABRR1	0	genome.wustl.edu	37	6	89907776	89907776	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	6	89907776	89907776	G	A	SNP	GABRR1	ENST00000454853	human	ensembl	74_37	-1	known	missense	c.535	p.R179W	1.000	pfam_Neur_chan_lig-bd,superfamily_Neur_chan_lig-bd,tigrfam_Neur_channel	pfam_Neur_chan_lig-bd,pfam_Neurotrans-gated_channel_TM,superfamily_Neur_chan_lig-bd,superfamily_Neurotrans-gated_channel_TM,prints_GABAA_rcpt,prints_GABAAa_rho1_rcpt,prints_Neur_channel,prints_GABAAa_rho_rcpt,tigrfam_Neur_channel	-	no_errors	GABRR1	HGNC	ENSG00000146276	tier1	rs201013212	-	65	0	0.00	31	64	67.37	95	0	0.00	106	147	57.87
KCNJ16	0	genome.wustl.edu	37	17	68128480	68128480	+	Silent	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	17	68128480	68128480	G	A	SNP	KCNJ16	ENST00000283936	human	ensembl	74_37	+1	known	silent	c.252	p.S84	0.794	pfam_K_chnl_inward-rec_Kir,pirsf_K_chnl_inward-rec_Kir,prints_K_chnl_inward-rec_Kir	pfam_K_chnl_inward-rec_Kir,superfamily_Ig_E-set,pirsf_K_chnl_inward-rec_Kir,prints_K_chnl_inward-rec_Kir5,prints_K_chnl_inward-rec_Kir	-	no_errors	KCNJ16	HGNC	ENSG00000153822	tier1	-	-	60	0	0.00	12	28	70.00	82	0	0.00	27	50	64.94
IGSF1	0	genome.wustl.edu	37	X	130408805	130408805	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	130408805	130408805	G	T	SNP	IGSF1	ENST00000370903	human	ensembl	74_37	-1	known	missense	c.3534	p.F1178L	1.000	smart_Ig_sub	pfam_Immunoglobulin,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	-	no_errors	IGSF1	HGNC	ENSG00000147255	tier1	-	-	90	0	0.00	132	15	10.20	113	1	0.88	213	39	15.35
PRSS1	0	genome.wustl.edu	37	7	142459862	142459862	+	Silent	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	7	142459862	142459862	C	T	SNP	PRSS1	ENST00000311737	human	ensembl	74_37	+1	known	silent	c.438	p.N146	1.000	pfam_Peptidase_S1,superfamily_Trypsin-like_Pept_dom,smart_Peptidase_S1,pfscan_Peptidase_S1	pfam_Peptidase_S1,superfamily_Trypsin-like_Pept_dom,smart_Peptidase_S1,pfscan_Peptidase_S1,prints_Peptidase_S1A	-	no_errors	PRSS1	HGNC	ENSG00000204983	tier1	-	-	31	0	0.00	21	27	56.25	31	0	0.00	55	33	37.50
GABRD	0	genome.wustl.edu	37	1	1959608	1959608	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	1	1959608	1959608	G	A	SNP	GABRD	ENST00000378585	human	ensembl	74_37	+1	known	missense	c.568	p.E190K	1.000	pfam_Neur_chan_lig-bd,superfamily_Neur_chan_lig-bd,tigrfam_Neur_channel	pfam_Neur_chan_lig-bd,pfam_Neurotrans-gated_channel_TM,superfamily_Neur_chan_lig-bd,superfamily_Neurotrans-gated_channel_TM,prints_GABAA_rcpt,prints_GABAAd_rcpt,prints_Neur_channel,tigrfam_Neur_channel	-	no_errors	GABRD	HGNC	ENSG00000187730	tier1	-	-	33	0	0.00	21	14	40.00	14	0	0.00	26	17	38.64
MYOM2	0	genome.wustl.edu	37	8	2024315	2024315	+	Silent	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	8	2024315	2024315	G	A	SNP	MYOM2	ENST00000262113	human	ensembl	74_37	+1	known	silent	c.1215	p.P405	0.015	pfam_Fibronectin_type3,superfamily_Fibronectin_type3,smart_Fibronectin_type3,pfscan_Fibronectin_type3	pfam_Fibronectin_type3,pfam_Ig_I-set,pfam_Ig_V-set,pfam_Immunoglobulin,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	MYOM2	HGNC	ENSG00000036448	tier1	-	-	71	0	0.00	79	31	28.18	32	0	0.00	30	16	34.78
ASPH	0	genome.wustl.edu	37	8	62438653	62438653	+	Missense_Mutation	SNP	T	T	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	8	62438653	62438653	T	C	SNP	ASPH	ENST00000379454	human	ensembl	74_37	-1	known	missense	c.1783	p.K595E	1.000	pfam_Asp_Arg_b-Hydrxlase	pfam_Asp-B-hydro/Triadin_dom,pfam_Asp_Arg_b-Hydrxlase,smart_TPR_repeat,pfscan_TPR_repeat,pfscan_TPR-contain_dom	-	no_errors	ASPH	HGNC	ENSG00000198363	tier1	-	-	46	0	0.00	51	11	17.74	79	0	0.00	95	28	22.76
DOCK4	0	genome.wustl.edu	37	7	111617310	111617310	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	7	111617310	111617310	G	A	SNP	DOCK4	ENST00000428084	human	ensembl	74_37	-1	known	missense	c.578	p.T193I	1.000	NULL	pfam_DOCK_C,pfam_SH3_2,superfamily_SH3_domain,superfamily_Rho_GTPase_activation_prot,superfamily_C2_dom,smart_SH3_domain,pfscan_SH3_domain	-	no_errors	DOCK4	HGNC	ENSG00000128512	tier1	-	-	56	0	0.00	48	53	52.48	65	0	0.00	60	43	41.75
PADI6	0	genome.wustl.edu	37	1	17707595	17707595	+	R	SNP	C	C	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	1	17707595	17707595	C	A	SNP	PADI6	ENST00000358481	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.017	-	-	-	no_errors	PADI6	HGNC	ENSG00000256049	tier1	-	-	26	0	0.00	37	23	38.33	82	0	0.00	85	61	41.78
GPR112	0	genome.wustl.edu	37	X	135405422	135405422	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	135405422	135405422	C	A	SNP	GPR112	ENST00000370652	human	ensembl	74_37	+1	known	missense	c.556	p.Q186K	1.000	pfam_Pentaxin,superfamily_ConA-like_lec_gl_sf,smart_Pentaxin	pfam_GPCR_2_secretin-like,pfam_GPS_dom,pfam_Pentaxin,superfamily_ConA-like_lec_gl_sf,smart_Pentaxin,smart_GPS_dom,pfscan_GPS_dom,pfscan_GPCR_2-like,prints_GPCR_2_secretin-like	-	no_errors	GPR112	HGNC	ENSG00000156920	tier1	-	-	44	0	0.00	83	22	20.95	93	0	0.00	121	36	22.93
FAM83F	0	genome.wustl.edu	37	22	40391373	40391373	+	Silent	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	22	40391373	40391373	C	T	SNP	FAM83F	ENST00000333407	human	ensembl	74_37	+1	known	silent	c.327	p.P109	0.983	pfam_DUF1669	pfam_DUF1669	-	no_errors	FAM83F	HGNC	ENSG00000133477	tier1	-	-	17	0	0.00	23	15	39.47	22	0	0.00	23	24	51.06
OPALIN	0	genome.wustl.edu	37	10	98109509	98109509	+	Silent	SNP	T	T	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	10	98109509	98109509	T	G	SNP	OPALIN	ENST00000371172	human	ensembl	74_37	-1	known	silent	c.147	p.L49	0.000	NULL	NULL	-	no_errors	OPALIN	HGNC	ENSG00000197430	tier1	-	-	36	0	0.00	13	18	58.06	54	0	0.00	17	55	76.39
OR12D3	0	genome.wustl.edu	37	6	29342525	29342525	+	Silent	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	6	29342525	29342525	C	T	SNP	OR12D3	ENST00000396806	human	ensembl	74_37	-1	known	silent	c.540	p.K180	0.071	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR12D3	HGNC	ENSG00000112462	tier1	-	-	20	0	0.00	17	4	19.05	89	0	0.00	96	29	23.20
LMTK2	0	genome.wustl.edu	37	7	97823854	97823854	+	Silent	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	7	97823854	97823854	C	T	SNP	LMTK2	ENST00000297293	human	ensembl	74_37	+1	known	silent	c.4077	p.F1359	0.635	NULL	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom,prints_Ser-Thr/Tyr_kinase_cat_dom	-	no_errors	LMTK2	HGNC	ENSG00000164715	tier1	-	-	34	0	0.00	36	27	42.19	109	0	0.00	96	57	37.01
OR7C1	0	genome.wustl.edu	37	19	14910160	14910160	+	Silent	SNP	T	T	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	19	14910160	14910160	T	C	SNP	OR7C1	ENST00000248073	human	ensembl	74_37	-1	known	silent	c.789	p.A263	0.000	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR7C1	HGNC	ENSG00000127530	tier1	-	-	49	0	0.00	25	32	56.14	38	0	0.00	40	32	44.44
CALCR	0	genome.wustl.edu	37	7	93106949	93106949	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	7	93106949	93106949	C	A	SNP	CALCR	ENST00000359558	human	ensembl	74_37	-1	known	missense	c.291	p.W97C	1.000	pfam_GPCR_2_extracellular_dom,smart_GPCR_2_extracellular_dom,pfscan_GPCR_2_extracellular_dom	pfam_GPCR_2_secretin-like,pfam_GPCR_2_extracellular_dom,smart_GPCR_2_extracellular_dom,pfscan_GPCR_2_extracellular_dom,pfscan_GPCR_2-like,prints_GCPR_2_calcitonin_rcpt_fam,prints_GPCR_2_secretin-like,prints_GPCR_2_calcitonin_rcpt	-	no_errors	CALCR	HGNC	ENSG00000004948	tier1	-	-	34	0	0.00	41	15	26.79	91	0	0.00	93	29	23.58
MET	0	genome.wustl.edu	37	7	116340033	116340033	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	7	116340033	116340033	A	T	SNP	MET	ENST00000318493	human	ensembl	74_37	+1	known	missense	c.895	p.I299F	1.000	pirsf_Tyr_kinase_HGF/MSP_rcpt,pfam_Semap_dom,superfamily_Semap_dom,smart_Semap_dom,pfscan_Semap_dom	pirsf_Tyr_kinase_HGF/MSP_rcpt,pfam_Semap_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,pfam_IPT,pfam_Plexin_repeat,superfamily_Semap_dom,superfamily_Kinase-like_dom,superfamily_Ig_E-set,superfamily_Plexin-like_fold,smart_Semap_dom,smart_Plexin-like_fold,smart_IPT,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,prints_Ser-Thr/Tyr_kinase_cat_dom,pfscan_Semap_dom,pfscan_Prot_kinase_dom	-	no_errors	MET	HGNC	ENSG00000105976	tier1	-	-	31	0	0.00	47	7	12.96	78	0	0.00	109	13	10.66
CAMTA1	0	genome.wustl.edu	37	1	7796530	7796530	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	1	7796530	7796530	G	A	SNP	CAMTA1	ENST00000303635	human	ensembl	74_37	+1	known	missense	c.3193	p.G1065R	1.000	superfamily_Ankyrin_rpt-contain_dom,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom	pfam_CG-1_dom,pfam_IPT,pfam_IQ_motif_EF-hand-BS,superfamily_Ig_E-set,superfamily_Ankyrin_rpt-contain_dom,superfamily_P-loop_NTPase,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,pfscan_IQ_motif_EF-hand-BS	-	no_errors	CAMTA1	HGNC	ENSG00000171735	tier1	-	-	43	0	0.00	37	6	13.64	86	0	0.00	124	18	12.68
OBSL1	0	genome.wustl.edu	37	2	220424007	220424007	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	2	220424007	220424007	C	T	SNP	OBSL1	ENST00000404537	human	ensembl	74_37	-1	known	missense	c.3166	p.G1056R	0.044	smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	pfam_Ig_I-set,pfam_Immunoglobulin,pfam_Ig_V-set,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	OBSL1	HGNC	ENSG00000124006	tier1	-	-	20	0	0.00	4	4	50.00	44	0	0.00	12	37	75.51
SLC2A6	0	genome.wustl.edu	37	9	136343454	136343454	+	Silent	SNP	T	T	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	9	136343454	136343454	T	C	SNP	SLC2A6	ENST00000371899	human	ensembl	74_37	-1	known	silent	c.177	p.T59	0.323	pfam_Sub_transporter,pfam_MFS,superfamily_MFS_dom_general_subst_transpt,pfscan_MFS_dom,tigrfam_Sugar/inositol_transpt	pfam_Sub_transporter,pfam_MFS,superfamily_MFS_dom_general_subst_transpt,pfscan_MFS_dom,prints_Sugar/inositol_transpt,tigrfam_Sugar/inositol_transpt	-	no_errors	SLC2A6	HGNC	ENSG00000160326	tier1	rs199947289	GMAF=0.0005	97	0	0.00	50	21	29.58	67	0	0.00	53	25	32.05
ADSL	0	genome.wustl.edu	37	22	40762509	40762509	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	22	40762509	40762509	G	A	SNP	ADSL	ENST00000454266	human	ensembl	74_37	+1	known	missense	c.1480	p.A494T	1.000	NULL	pfam_Fumarate_lyase_N,pfam_AdenyloSucc_lyase_C,superfamily_L-Aspartase-like,prints_Fumarate_lyase_fam,tigrfam_Pur_lyase	-	no_errors	ADSL	HGNC	ENSG00000239900	tier1	-	-	74	0	0.00	54	41	43.16	90	0	0.00	104	88	45.83
STARD8	0	genome.wustl.edu	37	X	67939184	67939184	+	Silent	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	67939184	67939184	G	A	SNP	STARD8	ENST00000374599	human	ensembl	74_37	+1	known	silent	c.1833	p.L611	0.998	NULL	pfam_START_lipid-bd_dom,pfam_RhoGAP_dom,superfamily_Rho_GTPase_activation_prot,smart_RhoGAP_dom,smart_START_lipid-bd_dom,pfscan_START_lipid-bd_dom,pfscan_RhoGAP_dom	-	no_errors	STARD8	HGNC	ENSG00000130052	tier1	-	-	90	0	0.00	29	53	64.63	44	0	0.00	10	15	60.00
GJD2	0	genome.wustl.edu	37	15	35045464	35045464	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	15	35045464	35045464	C	A	SNP	GJD2	ENST00000290374	human	ensembl	74_37	-1	known	missense	c.181	p.G61C	1.000	pfam_Connexin_N,smart_Connexin_N,prints_Connexin	pfam_Connexin_N,pfam_Connexin_CCC,smart_Connexin_N,prints_Connexin,prints_Connexin36	-	no_errors	GJD2	HGNC	ENSG00000159248	tier1	-	-	44	0	0.00	16	10	38.46	93	0	0.00	60	27	31.03
FGD3	0	genome.wustl.edu	37	9	95796885	95796885	+	Silent	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	9	95796885	95796885	C	T	SNP	FGD3	ENST00000337352	human	ensembl	74_37	+1	known	silent	c.1848	p.S616	0.000	smart_Pleckstrin_homology,pfscan_Pleckstrin_homology	pfam_DH-domain,pfam_Pleckstrin_homology,pfam_Znf_FYVE,superfamily_DH-domain,superfamily_Znf_FYVE_PHD,smart_DH-domain,smart_Pleckstrin_homology,smart_Znf_FYVE,pfscan_Pleckstrin_homology,pfscan_Znf_FYVE-rel,pfscan_DH-domain	-	no_errors	FGD3	HGNC	ENSG00000127084	tier1	-	-	40	0	0.00	44	27	38.03	11	0	0.00	13	11	45.83
SGK223	0	genome.wustl.edu	37	8	8234395	8234395	+	Silent	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	8	8234395	8234395	G	A	SNP	SGK223	ENST00000330777	human	ensembl	74_37	-1	known	silent	c.1524	p.S508	0.001	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,pfscan_Prot_kinase_dom	-	no_errors	SGK223	Uniprot_gn	ENSG00000182319	tier1	rs200101338	-	55	0	0.00	57	13	18.57	43	0	0.00	61	10	14.08
CPAMD8	0	genome.wustl.edu	37	19	17040028	17040028	+	Silent	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	19	17040028	17040028	G	A	SNP	CPAMD8	ENST00000443236	human	ensembl	74_37	-1	known	silent	c.3009	p.P1003	0.999	NULL	pfam_A2M_comp,pfam_A2M_N_2,pfam_Methyltransf_FA,pfam_Macroglobln_a2,pfam_A-macroglobulin_rcpt-bd,pfam_A2M_N,pfam_MacrogloblnA2_thiol-ester-bond,pfam_Kazal_dom,superfamily_Terpenoid_cyclase/PrenylTrfase,superfamily_A-macroglobulin_rcpt-bd,smart_Kazal_dom	-	no_errors	CPAMD8	HGNC	ENSG00000160111	tier1	-	-	63	0	0.00	47	14	22.95	62	0	0.00	44	26	37.14
SEC14L6	0	genome.wustl.edu	37	22	30925097	30925097	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	22	30925097	30925097	C	T	SNP	SEC14L6	ENST00000402034	human	ensembl	74_37	-1	novel	missense	c.641	p.R214H	0.571	pfam_CRAL-TRIO_dom,superfamily_CRAL-TRIO_dom,smart_CRAL-TRIO_dom,pfscan_CRAL-TRIO_dom,prints_CRAL-bd_toc_tran	pfam_CRAL-TRIO_dom,pfam_CRAL/TRIO_N_dom,superfamily_CRAL-TRIO_dom,superfamily_GOLD,superfamily_CRAL/TRIO_N_dom,smart_CRAL-TRIO_dom,pfscan_CRAL-TRIO_dom,pfscan_GOLD,prints_CRAL-bd_toc_tran	-	no_errors	SEC14L6	HGNC	ENSG00000214491	tier1	-	-	31	0	0.00	3	7	70.00	13	0	0.00	14	22	61.11
TGS1	0	genome.wustl.edu	37	8	56698829	56698829	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	8	56698829	56698829	A	G	SNP	TGS1	ENST00000260129	human	ensembl	74_37	+1	known	missense	c.372	p.I124M	0.006	NULL	pfam_R_cap_Gua-N2-MeTrfase,pfam_R_methylase_dom,pfam_tR_Trfase_Trm5/Tyw2	-	no_errors	TGS1	HGNC	ENSG00000137574	tier1	-	-	36	0	0.00	21	13	38.24	30	0	0.00	30	6	16.22
HMCN1	0	genome.wustl.edu	37	1	186151337	186151337	+	Missense_Mutation	SNP	T	T	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	1	186151337	186151337	T	G	SNP	HMCN1	ENST00000271588	human	ensembl	74_37	+1	known	missense	c.16332	p.H5444Q	0.999	pfam_EGF-like_Ca-bd_dom,superfamily_Growth_fac_rcpt_N_dom,smart_EGF-like_Ca-bd_dom,smart_EG-like_dom,pfscan_EG-like_dom	pfam_Ig_I-set,pfam_Immunoglobulin,pfam_Ig_V-set,pfam_G2_nidogen/fibulin_G2F,pfam_EGF-like_Ca-bd_dom,pfam_Thrombospondin_1_rpt,superfamily_GFP,superfamily_Thrombospondin_1_rpt,superfamily_Growth_fac_rcpt_N_dom,superfamily_Cadherin-like,smart_Ig_sub,smart_Ig_sub2,smart_Ig_V-set_subgr,smart_Thrombospondin_1_rpt,smart_G2_nidogen/fibulin_G2F,smart_EGF-like_Ca-bd_dom,smart_EG-like_dom,pfscan_EG-like_dom,pfscan_G2_nidogen/fibulin_G2F,pfscan_Thrombospondin_1_rpt,pfscan_Ig-like_dom	-	no_errors	HMCN1	HGNC	ENSG00000143341	tier1	-	-	24	0	0.00	30	20	40.00	56	0	0.00	64	41	39.05
TARS	0	genome.wustl.edu	37	5	33463875	33463875	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	5	33463875	33463875	C	T	SNP	TARS	ENST00000265112	human	ensembl	74_37	+1	known	missense	c.1853	p.P618L	1.000	superfamily_Anticodon-bd,prints_Thr-tR-ligase_IIa,tigrfam_Thr-tR-ligase_IIa	pfam_aa-tR-synt_IIb_cons-dom,pfam_Anticodon-bd,pfam_TGS,pfam_tR_SAD,superfamily_Thr/Ala-tR-synth_IIc_edit,superfamily_Anticodon-bd,superfamily_TGS-like,smart_tR_SAD,prints_Thr-tR-ligase_IIa,pfscan_aa-tR-synth_II,tigrfam_Thr-tR-ligase_IIa	-	no_errors	TARS	HGNC	ENSG00000113407	tier1	-	-	61	0	0.00	15	23	58.97	95	0	0.00	23	58	71.60
ZNF225	0	genome.wustl.edu	37	19	44622636	44622636	+	Silent	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	19	44622636	44622636	G	T	SNP	ZNF225	ENST00000262894	human	ensembl	74_37	+1	known	silent	c.144	p.G48	0.001	pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,pfscan_Krueppel-associated_box	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF225	HGNC	ENSG00000256294	tier1	-	-	90	0	0.00	44	12	21.43	57	0	0.00	86	24	21.82
NLRP9	0	genome.wustl.edu	37	19	56220321	56220321	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	19	56220321	56220321	G	C	SNP	NLRP9	ENST00000332836	human	ensembl	74_37	-1	known	missense	c.2933	p.P978R	0.000	NULL	pfam_DAPIN,superfamily_DEATH-like_dom,superfamily_P-loop_NTPase,smart_Leu-rich_rpt_RNase_inh_sub-typ,pfscan_CHT_NTPase,pfscan_DAPIN	-	no_errors	NLRP9	HGNC	ENSG00000185792	tier1	-	-	56	0	0.00	62	19	23.46	136	0	0.00	106	25	19.08
IGSF1	0	genome.wustl.edu	37	X	130409008	130409008	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	130409008	130409008	G	T	SNP	IGSF1	ENST00000370903	human	ensembl	74_37	-1	known	nonsense	c.3452	p.S1151*	0.857	smart_Ig_sub	pfam_Immunoglobulin,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	-	no_errors	IGSF1	HGNC	ENSG00000147255	tier1	-	-	60	0	0.00	66	16	19.51	80	0	0.00	155	24	13.41
NF2	0	genome.wustl.edu	37	22	30032860	30032860	+	Nonsense_Mutation	SNP	A	A	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	22	30032860	30032860	A	T	SNP	NF2	ENST00000338641	human	ensembl	74_37	+1	known	nonsense	c.235	p.K79*	1.000	pirsf_ERM,pfam_FERM_N,smart_Band_41_domain,pfscan_FERM_domain	pirsf_ERM,pfam_ERM_C_dom,pfam_FERM_PH-like_C,pfam_FERM_central,pfam_FERM_N,superfamily_FERM_central,superfamily_Moesin_tail,smart_Band_41_domain,pfscan_FERM_domain,prints_Ez/rad/moesin_like,prints_Band_41_fam,prints_Tropomyosin	-	no_errors	NF2	HGNC	ENSG00000186575	tier1	-	-	54	0	0.00	11	33	73.33	75	0	0.00	33	69	67.65
ERVH48-1	0	genome.wustl.edu	37	21	44339204	44339207	+	R	DEL	CAGA	CAGA	-			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	CAGA	CAGA	CAGA	-	CAGA	CAGA	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	21	44339204	44339207	CAGA	-	DEL	ERVH48-1	ENST00000447535	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.012:0.014:0.015:0.016	-	-	-	no_errors	ERVH48-1	HGNC	ENSG00000233056	tier1			25	0	0.00	8	5	38.46	75	0	0.00	53	17	24.29
ENSG00000228506	0	genome.wustl.edu	37	6	99873377	99873377	+	R	DEL	T	T	-			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	T	T	T	-	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	6	99873377	99873377	T	-	DEL	ENSG00000228506	ENST00000418945	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	RP11-98I9.4	Clone_based_vega_gene	ENSG00000228506	tier1			14	0	0.00	26	7	21.21	77	0	0.00	199	25	11.16
ARHGAP27	0	genome.wustl.edu	37	17	43472842	43472842	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	-	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	17	43472842	43472842	C	-	DEL	ARHGAP27	ENST00000428638	human	ensembl	74_37	-1	known	frame_shift_del	c.2650	p.D884fs	0.234	superfamily_Rho_GTPase_activation_prot,pfscan_RhoGAP_dom	pfam_RhoGAP_dom,pfam_WW_dom,pfam_Pleckstrin_homology,superfamily_Rho_GTPase_activation_prot,superfamily_SH3_domain,superfamily_WW_dom,smart_WW_dom,smart_Pleckstrin_homology,smart_RhoGAP_dom,pfscan_Pleckstrin_homology,pfscan_SH3_domain,pfscan_WW_dom,pfscan_RhoGAP_dom	-	no_errors	ARHGAP27	HGNC	ENSG00000159314	tier1			30	0	0.00	20	17	45.95	11	0	0.00	17	6	26.09
SMARCA5	0	genome.wustl.edu	37	4	144442729	144442731	+	In_Frame_Del	DEL	AAC	AAC	-			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	AAC	AAC	AAC	-	AAC	AAC	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	4	144442729	144442731	AAC	-	DEL	SMARCA5	ENST00000283131	human	ensembl	74_37	+1	known	in_frame_del	c.400_402	p.N134in_frame_del	1.000:1.000:1.000	superfamily_P-loop_NTPase	pfam_SNF2_N,pfam_SLIDE,pfam_ISWI_HAND-dom,pfam_Helicase_C,pfam_Helicase/UvrB_dom,pfam_HDA_complex_subunit-2/3,pfam_D/R_helicase_DEAD/DEAH_N,superfamily_P-loop_NTPase,superfamily_Homeodomain-like,superfamily_ISWI_HAND-dom,smart_Helicase_ATP-bd,smart_Helicase_C,smart_SANT/Myb,pfscan_Helicase_ATP-bd,pfscan_Helicase_C	-	no_errors	SMARCA5	HGNC	ENSG00000153147	tier1			85	0	0.00	92	38	29.23	119	0	0.00	140	60	30.00
ASMT	0	genome.wustl.edu	37	X	1743283	1743283	+	Silent	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	1743283	1743283	C	T	SNP	ASMT	ENST00000381241	human	ensembl	74_37	+1	known	silent	c.366	p.D122	0.452	pfam_O_MeTrfase_2,pirsf_COMT	pfam_O_MeTrfase_2,pirsf_COMT	-	no_errors	ASMT	HGNC	ENSG00000196433	tier1	-	-	78	0	0.00	13	57	80.28	7	0	0.00	4	23	85.19
FOSB	0	genome.wustl.edu	37	19	45974168	45974168	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	-	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	19	45974168	45974168	C	-	DEL	FOSB	ENST00000353609	human	ensembl	74_37	+1	known	frame_shift_del	c.408	p.P137fs	1.000	NULL	pfam_bZIP,superfamily_TF_D-bd,smart_bZIP,pfscan_bZIP,prints_Leuzip_Fos	-	no_errors	FOSB	HGNC	ENSG00000125740	tier1			12	0	0.00	15	6	28.57	9	0	0.00	9	4	30.77
JAKMIP3	0	genome.wustl.edu	37	10	133976760	133976760	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	10	133976760	133976760	G	T	SNP	JAKMIP3	ENST00000298622	human	ensembl	74_37	+1	known	missense	c.2262	p.E754D	0.686	NULL	NULL	-	no_errors	JAKMIP3	HGNC	ENSG00000188385	tier1	-	-	45	0	0.00	12	40	76.92	17	0	0.00	4	9	69.23
PLX3	0	genome.wustl.edu	37	X	153692617	153692617	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	153692617	153692617	C	T	SNP	PLX3	ENST00000369682	human	ensembl	74_37	+1	known	missense	c.1789	p.P597S	0.999	NULL	pfam_Plexin_cytoplasmic_RasGAP_dom,pfam_Semap_dom,pfam_IPT,pfam_Plexin_repeat,superfamily_Semap_dom,superfamily_Rho_GTPase_activation_prot,superfamily_Ig_E-set,superfamily_Plexin-like_fold,smart_Semap_dom,smart_Plexin-like_fold,smart_IPT,pfscan_Semap_dom	-	no_errors	PLX3	HGNC	ENSG00000130827	tier1	-	-	21	0	0.00	17	4	19.05	22	0	0.00	5	3	37.50
MYH4	0	genome.wustl.edu	37	17	10351814	10351814	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	17	10351814	10351814	G	T	SNP	MYH4	ENST00000255381	human	ensembl	74_37	-1	known	missense	c.4555	p.Q1519K	1.000	pfam_Myosin_tail,superfamily_tR-bd_arm	pfam_Myosin_tail,pfam_Myosin_head_motor_dom,pfam_Myosin_N,superfamily_P-loop_NTPase,superfamily_Prefoldin,superfamily_tR-bd_arm,smart_Myosin_head_motor_dom,pfscan_IQ_motif_EF-hand-BS,prints_Myosin_head_motor_dom	-	no_errors	MYH4	HGNC	ENSG00000264424	tier1	-	-	34	0	0.00	72	17	19.10	93	0	0.00	227	24	9.49
UCP1	0	genome.wustl.edu	37	4	141489848	141489848	+	Silent	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	4	141489848	141489848	G	T	SNP	UCP1	ENST00000262999	human	ensembl	74_37	-1	known	silent	c.36	p.T12	1.000	superfamily_Mt_carrier_dom,pfscan_Mitochondrial_sb/sol_carrier	pfam_Mitochondrial_sb/sol_carrier,superfamily_Mt_carrier_dom,pfscan_Mitochondrial_sb/sol_carrier,prints_Mit_uncoupling	-	no_errors	UCP1	HGNC	ENSG00000109424	tier1	-	-	41	0	0.00	41	12	22.64	33	0	0.00	56	4	6.56
PCDHA4	0	genome.wustl.edu	37	5	140187880	140187880	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	5	140187880	140187880	G	A	SNP	PCDHA4	ENST00000530339	human	ensembl	74_37	+1	known	missense	c.1108	p.A370T	0.882	pfam_Cadherin,superfamily_Cadherin-like,pfscan_Cadherin	pfam_Cadherin,pfam_Cadherin_N,superfamily_Cadherin-like,smart_Cadherin,prints_Cadherin,pfscan_Cadherin	-	no_errors	PCDHA4	HGNC	ENSG00000204967	tier1	-	-	55	0	0.00	69	6	8.00	65	0	0.00	99	10	9.17
IGSF1	0	genome.wustl.edu	37	X	130408707	130408707	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	X	130408707	130408707	G	C	SNP	IGSF1	ENST00000370903	human	ensembl	74_37	-1	known	nonsense	c.3632	p.S1211*	0.957	smart_Ig_sub,smart_Ig_sub2	pfam_Immunoglobulin,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	-	no_errors	IGSF1	HGNC	ENSG00000147255	tier1	-	-	45	0	0.00	76	10	11.63	117	0	0.00	188	20	9.62
ZCRB1	0	genome.wustl.edu	37	12	42706971	42706971	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	T	T	T	-	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	12	42706971	42706971	T	-	DEL	ZCRB1	ENST00000266529	human	ensembl	74_37	-1	known	frame_shift_del	c.552	p.K184fs	0.732	NULL	pfam_RRM_dom,pfam_Znf_CCHC,superfamily_Znf_CCHC,smart_RRM_dom_euk,smart_RRM_dom,smart_Znf_CCHC,pfscan_Znf_CCHC,pfscan_RRM_dom	-	no_errors	ZCRB1	HGNC	ENSG00000139168	tier1			54	0	0.00	35	4	10.26	78	0	0.00	72	4	5.26
SRGAP3	0	genome.wustl.edu	37	3	9034675	9034675	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	3	9034675	9034675	G	T	SNP	SRGAP3	ENST00000383836	human	ensembl	74_37	-1	known	missense	c.2473	p.L825M	1.000	superfamily_SH3_domain	pfam_RhoGAP_dom,pfam_FCH_dom,pfam_SH3_domain,pfam_SH3_2,superfamily_Rho_GTPase_activation_prot,superfamily_SH3_domain,smart_FCH_dom,smart_RhoGAP_dom,smart_SH3_domain,pfscan_FCH_dom,pfscan_SH3_domain,pfscan_RhoGAP_dom	-	no_errors	SRGAP3	HGNC	ENSG00000196220	tier1	-	-	38	0	0.00	39	7	15.22	34	1	2.86	58	14	19.44
BCR	0	genome.wustl.edu	37	22	23523835	23523835	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	22	23523835	23523835	C	A	SNP	BCR	ENST00000305877	human	ensembl	74_37	+1	known	missense	c.688	p.P230T	0.000	NULL	pfam_RhoGAP_dom,pfam_Bcr-Abl_oncoprot_oligo,pfam_DH-domain,pfam_C2_dom,pfam_Pleckstrin_homology,superfamily_Rho_GTPase_activation_prot,superfamily_DH-domain,superfamily_Bcr-Abl_oncoprot_oligo,superfamily_C2_dom,smart_DH-domain,smart_Pleckstrin_homology,smart_C2_dom,smart_RhoGAP_dom,pfscan_C2_dom,pfscan_Pleckstrin_homology,pfscan_RhoGAP_dom,pfscan_DH-domain	-	no_errors	BCR	HGNC	ENSG00000186716	tier1	-	-	37	0	0.00	31	4	11.11	6	0	0.00	4	0	0.00
ELMSAN1	0	genome.wustl.edu	37	14	74205954	74205956	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	TGC	TGC					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	14	74205954	74205956	TGC	-	DEL	ELMSAN1	ENST00000286523	human	ensembl	74_37	-1	known	in_frame_del	c.758_756	p.Q253in_frame_del	0.074:0.180:0.001	NULL	pfam_ELM2_dom,superfamily_Homeodomain-like,smart_SANT/Myb,pfscan_ELM2_dom	-	no_errors	ELMSAN1	HGNC	ENSG00000156030	tier1			39	0	0.00	40	5	11.11	9	0	0.00	5	0	0.00
OR13A1	0	genome.wustl.edu	37	10	45799437	45799437	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	10	45799437	45799437	C	A	SNP	OR13A1	ENST00000374401	human	ensembl	74_37	-1	known	missense	c.434	p.C145F	1.000	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR13A1	HGNC	ENSG00000256574	tier1	-	-	18	0	0.00	5	7	58.33	7	0	0.00	9	1	10.00
POTEJ	0	genome.wustl.edu	37	2	131369279	131369279	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	2	131369279	131369279	G	T	SNP	POTEJ	ENST00000409602	human	ensembl	74_37	+1	novel	missense	c.174	p.R58S	0.012	NULL	pfam_Actin-related,pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,smart_Actin-related,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,prints_Actin-related	-	no_errors	POTEJ	HGNC	ENSG00000222038	tier1	-	-	37	0	0.00	10	2	16.67	8	0	0.00	7	0	0.00
SFTPB	0	genome.wustl.edu	37	2	85895264	85895266	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	GCA	GCA					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	2	85895264	85895266	GCA	-	DEL	SFTPB	ENST00000393822	human	ensembl	74_37	-1	known	in_frame_del	c.79_77	p.L26in_frame_del	0.966:0.981:0.990	NULL	pfam_SapB_2,pfam_SapA,pfam_SapB_1,superfamily_Saposin-like,smart_SapA,smart_SaposinB,pfscan_SapA,pfscan_SaposinB,prints_Saposin	-	no_errors	SFTPB	HGNC	ENSG00000168878	tier1			18	0	0.00	15	2	11.76	12	0	0.00	5	1	16.67
CEP97	0	genome.wustl.edu	37	3	101481976	101481976	+	Silent	SNP	C	C	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	3	101481976	101481976	C	T	SNP	CEP97	ENST00000327230	human	ensembl	74_37	+1	known	silent	c.1917	p.P639	0.008	NULL	pfam_IQ_motif_EF-hand-BS,superfamily_P-loop_NTPase,pfscan_IQ_motif_EF-hand-BS	-	no_errors	CEP97	HGNC	ENSG00000182504	tier1	-	-	74	0	0.00	48	26	35.14	0	0	0.00	0	0	0.00
FAM230B	0	genome.wustl.edu	37	22	21537771	21537771	+	R	SNP	G	G	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	22	21537771	21537771	G	C	SNP	FAM230B	ENST00000451257	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.022	-	-	-	no_errors	FAM230B	HGNC	ENSG00000215498	tier1	rs63749487	-	37	0	0.00	14	3	17.65	4	0	0.00	2	0	0.00
PKD1	0	genome.wustl.edu	37	16	2153897	2153897	+	Splice_Site	SNP	C	C	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	16	2153897	2153897	C	A	SNP	PKD1	ENST00000262304	human	ensembl	74_37	-1	known	splice_site	c.8162-1	e23-1	0.998	-	-	-	no_errors	PKD1	HGNC	ENSG00000008710	tier1	-	-	41	0	0.00	35	4	10.26	0	0	0.00	0	0	0.00
RSET2	0	genome.wustl.edu	37	6	167369655	167369655	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	6	167369655	167369655	G	T	SNP	RSET2	ENST00000476238	human	ensembl	74_37	-1	known	missense	c.16	p.L6M	0.000	NULL	pfam_RNase_T2-like,superfamily_RNase_T2-like	-	no_errors	RSET2	HGNC	ENSG00000026297	tier1	-	-	39	0	0.00	40	5	11.11	2	0	0.00	2	0	0.00
TBP	0	genome.wustl.edu	37	6	170871004	170871004	+	Silent	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	6	170871004	170871004	G	A	SNP	TBP	ENST00000230354	human	ensembl	74_37	+1	known	silent	c.180	p.Q60	0.991	NULL	pfam_TBP,prints_TBP	-	no_errors	TBP	HGNC	ENSG00000112592	tier1	-	-	43	0	0.00	43	11	20.37	0	0	0.00	3	0	0.00
UNC93B6	0	genome.wustl.edu	37	11	71314423	71314423	+	R	SNP	G	G	A			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	11	71314423	71314423	G	A	SNP	UNC93B6	ENST00000525262	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.996	-	-	-	no_errors	UNC93B6	HGNC	ENSG00000255562	tier1	-	-	115	0	0.00	61	60	49.59	0	0	0.00	0	0	0.00
USP17L2	0	genome.wustl.edu	37	8	11995398	11995398	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	8	11995398	11995398	A	G	SNP	USP17L2	ENST00000333796	human	ensembl	74_37	-1	known	missense	c.872	p.L291P	0.001	pfam_Peptidase_C19/C67,pfscan_Peptidase_C19/C67	pfam_Peptidase_C19/C67,pfam_HABP4_PAIRBP1-bd,pfscan_Peptidase_C19/C67	-	no_errors	USP17L2	HGNC	ENSG00000223443	tier1	-	-	98	0	0.00	83	29	25.89	3	0	0.00	8	1	11.11
POTEG	0	genome.wustl.edu	37	14	19559063	19559063	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-A6YQ-01A-12D-A33E-09	TCGA-DX-A6YQ-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	a7be76f9-2aaa-4fbe-95d0-7a1a304f48e8	d69e4b21-e6ab-4164-9ba6-809891a82b67	14	19559063	19559063	G	C	SNP	POTEG	ENST00000409832	human	ensembl	74_37	+1	known	missense	c.709	p.E237Q	0.000	superfamily_Ankyrin_rpt-contain_dom,pfscan_Ankyrin_rpt-contain_dom	pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,prints_Ankyrin_rpt	-	no_errors	POTEG	HGNC	ENSG00000222036	tier1	-	-	258	0	0.00	241	35	12.68	37	0	0.00	29	3	9.38