Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
FMNL2	0	genome.wustl.edu	37	2	153475531	153475531	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	2	153475531	153475531	G	A	SNP	FMNL2	ENST00000288670	human	ensembl	74_37	+1	known	missense	c.1486	p.V496I	0.896	NULL	pfam_FH2_Formin,pfam_FH3_dom,pfam_GTPase-bd,superfamily_ARM-type_fold,smart_FH2_Formin,prints_Wilms_tumour	-	no_errors	FMNL2	HGNC	ENSG00000157827	tier1	-	-	39	0	0.00	76	13	14.61	89	0	0.00	119	32	21.19
FMNL2	0	genome.wustl.edu	37	2	153475473	153475473	+	Silent	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	2	153475473	153475473	G	A	SNP	FMNL2	ENST00000288670	human	ensembl	74_37	+1	known	silent	c.1428	p.E476	1.000	NULL	pfam_FH2_Formin,pfam_FH3_dom,pfam_GTPase-bd,superfamily_ARM-type_fold,smart_FH2_Formin,prints_Wilms_tumour	-	no_errors	FMNL2	HGNC	ENSG00000157827	tier1	-	-	48	0	0.00	66	12	15.38	92	0	0.00	141	28	16.57
ATP2C2	0	genome.wustl.edu	37	16	84444193	84444193	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	16	84444193	84444193	C	T	SNP	ATP2C2	ENST00000262429	human	ensembl	74_37	+1	known	missense	c.437	p.T146I	0.993	pfam_ATPase_P-typ_transduc_dom_A,tigrfam_ATPase_P-typ_Ca-transp_PMR1	pfam_ATPase_P-typ_transduc_dom_A,pfam_ATPase_P-typ_cation-transptr_C,pfam_HAD-like_dom,pfam_ATPase_P-typ_cation-transptr_N,superfamily_ATPase_P-typ_cyto_domN,superfamily_HAD-like_dom,smart_ATPase_P-typ_cation-transptr_N,prints_Cation_transp_P_typ_ATPase,tigrfam_ATPase_P-typ_Ca-transp_PMR1,tigrfam_Cation_transp_P_typ_ATPase	-	no_errors	ATP2C2	HGNC	ENSG00000064270	tier1	-	-	22	0	0.00	34	8	19.05	68	0	0.00	33	11	25.00
FMNL2	0	genome.wustl.edu	37	2	153475615	153475615	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	2	153475615	153475615	G	A	SNP	FMNL2	ENST00000288670	human	ensembl	74_37	+1	known	missense	c.1570	p.G524R	0.686	NULL	pfam_FH2_Formin,pfam_FH3_dom,pfam_GTPase-bd,superfamily_ARM-type_fold,smart_FH2_Formin,prints_Wilms_tumour	-	no_errors	FMNL2	HGNC	ENSG00000157827	tier1	-	-	31	0	0.00	119	21	15.00	57	0	0.00	105	22	17.32
BRWD3	0	genome.wustl.edu	37	X	79989633	79989633	+	Missense_Mutation	SNP	T	T	G			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	X	79989633	79989633	T	G	SNP	BRWD3	ENST00000373275	human	ensembl	74_37	-1	known	missense	c.1070	p.E357A	1.000	pfam_WD40_repeat,superfamily_Quino_amine_DH_bsu,smart_WD40_repeat,pfscan_WD40_repeat_dom	pfam_WD40_repeat,pfam_Bromodomain,superfamily_Quino_amine_DH_bsu,superfamily_Bromodomain,smart_WD40_repeat,smart_Bromodomain,pfscan_Bromodomain,pfscan_WD40_repeat,pfscan_WD40_repeat_dom,prints_Bromodomain	-	no_errors	BRWD3	HGNC	ENSG00000165288	tier1	-	-	177	0	0.00	89	29	24.58	94	0	0.00	66	30	31.25
OR6T1	0	genome.wustl.edu	37	11	123813912	123813912	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	11	123813912	123813912	C	A	SNP	OR6T1	ENST00000321252	human	ensembl	74_37	-1	known	missense	c.634	p.A212S	0.000	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR6T1	HGNC	ENSG00000181499	tier1	-	-	35	0	0.00	5	24	82.76	69	0	0.00	19	46	70.77
TMPRSS15	0	genome.wustl.edu	37	21	19732162	19732162	+	Silent	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	21	19732162	19732162	G	A	SNP	TMPRSS15	ENST00000284885	human	ensembl	74_37	-1	known	silent	c.792	p.S264	0.954	pfam_CUB_dom,superfamily_CUB_dom,smart_CUB_dom,pfscan_CUB_dom	pfam_Peptidase_S1,pfam_CUB_dom,pfam_MAM_dom,pfam_SEA_dom,pfam_LDrepeatLR_classA_rpt,pfam_Peptidase_S1A_nudel,pfam_SRCR,superfamily_Trypsin-like_Pept_dom,superfamily_ConA-like_lec_gl_sf,superfamily_CUB_dom,superfamily_LDrepeatLR_classA_rpt,superfamily_Srcr_rcpt-rel,smart_SEA_dom,smart_LDrepeatLR_classA_rpt,smart_CUB_dom,smart_MAM_dom,smart_Srcr_rcpt-rel,smart_Peptidase_S1,pfscan_CUB_dom,pfscan_LDrepeatLR_classA_rpt,pfscan_MAM_dom,pfscan_SEA_dom,pfscan_SRCR,pfscan_Peptidase_S1,prints_Peptidase_S1A,prints_LDrepeatLR_classA_rpt	-	no_errors	TMPRSS15	HGNC	ENSG00000154646	tier1	-	-	141	1	0.70	42	23	35.38	86	0	0.00	54	28	34.15
FMNL2	0	genome.wustl.edu	37	2	153475465	153475465	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	2	153475465	153475465	G	A	SNP	FMNL2	ENST00000288670	human	ensembl	74_37	+1	known	missense	c.1420	p.E474K	1.000	pfam_FH3_dom	pfam_FH2_Formin,pfam_FH3_dom,pfam_GTPase-bd,superfamily_ARM-type_fold,smart_FH2_Formin,prints_Wilms_tumour	-	no_errors	FMNL2	HGNC	ENSG00000157827	tier1	-	-	50	0	0.00	67	11	14.10	97	0	0.00	131	24	15.48
EIF4G3	0	genome.wustl.edu	37	1	21167469	21167469	+	Missense_Mutation	SNP	A	A	G			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	1	21167469	21167469	A	G	SNP	EIF4G3	ENST00000374937	human	ensembl	74_37	-1	known	missense	c.3791	p.F1264S	1.000	pfam_Initiation_fac_eIF4g_MI,superfamily_ARM-type_fold,smart_Initiation_fac_eIF4g_MI	pfam_MIF4G-like_typ-3,pfam_Initiation_fac_eIF4g_MI,pfam_W2_domain,superfamily_ARM-type_fold,smart_MIF4G-like_typ-3,smart_Initiation_fac_eIF4g_MI,smart_W2_domain	-	no_errors	EIF4G3	HGNC	ENSG00000075151	tier1	-	-	47	0	0.00	54	32	37.21	94	0	0.00	67	34	33.66
FMNL2	0	genome.wustl.edu	37	2	153475500	153475500	+	Silent	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	2	153475500	153475500	G	A	SNP	FMNL2	ENST00000288670	human	ensembl	74_37	+1	known	silent	c.1455	p.K485	1.000	NULL	pfam_FH2_Formin,pfam_FH3_dom,pfam_GTPase-bd,superfamily_ARM-type_fold,smart_FH2_Formin,prints_Wilms_tumour	-	no_errors	FMNL2	HGNC	ENSG00000157827	tier1	-	-	40	0	0.00	69	15	17.86	91	1	1.09	132	32	19.51
SIX4	0	genome.wustl.edu	37	14	61180804	61180804	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	14	61180804	61180804	G	A	SNP	SIX4	ENST00000216513	human	ensembl	74_37	-1	known	missense	c.1667	p.T556M	1.000	NULL	pfam_Homeobox_dom,superfamily_Homeodomain-like,smart_Homeobox_dom,pfscan_Homeobox_dom	-	no_errors	SIX4	HGNC	ENSG00000100625	tier1	-	-	42	0	0.00	32	14	30.43	75	0	0.00	52	32	38.10
UGT3A2	0	genome.wustl.edu	37	5	36035888	36035888	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	5	36035888	36035888	A	T	SNP	UGT3A2	ENST00000282507	human	ensembl	74_37	-1	known	missense	c.1484	p.L495H	0.019	pfam_UDP_glucos_trans	pfam_UDP_glucos_trans,pfam_Glyco_trans_28_C	-	no_errors	UGT3A2	HGNC	ENSG00000168671	tier1	-	-	17	0	0.00	26	15	36.59	46	0	0.00	46	23	33.33
IGDCC3	0	genome.wustl.edu	37	15	65621811	65621811	+	Missense_Mutation	SNP	C	C	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	15	65621811	65621811	C	A	SNP	IGDCC3	ENST00000327987	human	ensembl	74_37	-1	known	missense	c.2122	p.D708Y	0.007	NULL	pfam_Ig_I-set,pfam_Immunoglobulin,pfam_Fibronectin_type3,pfam_Ig_V-set,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	IGDCC3	HGNC	ENSG00000174498	tier1	-	-	60	0	0.00	50	31	38.27	15	0	0.00	10	8	44.44
KIAA0355	0	genome.wustl.edu	37	19	34819042	34819042	+	Missense_Mutation	SNP	C	C	G			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	19	34819042	34819042	C	G	SNP	KIAA0355	ENST00000299505	human	ensembl	74_37	+1	known	missense	c.1090	p.L364V	1.000	NULL	NULL	-	no_errors	KIAA0355	HGNC	ENSG00000166398	tier1	-	-	30	0	0.00	49	9	15.52	77	0	0.00	42	10	19.23
FMNL2	0	genome.wustl.edu	37	2	153475423	153475423	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	2	153475423	153475423	G	A	SNP	FMNL2	ENST00000288670	human	ensembl	74_37	+1	known	missense	c.1378	p.E460K	1.000	pfam_FH3_dom	pfam_FH2_Formin,pfam_FH3_dom,pfam_GTPase-bd,superfamily_ARM-type_fold,smart_FH2_Formin,prints_Wilms_tumour	-	no_errors	FMNL2	HGNC	ENSG00000157827	tier1	-	-	50	0	0.00	58	12	17.14	79	0	0.00	123	17	11.89
FMNL2	0	genome.wustl.edu	37	2	153475564	153475564	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	2	153475564	153475564	G	A	SNP	FMNL2	ENST00000288670	human	ensembl	74_37	+1	known	missense	c.1519	p.E507K	0.085	prints_Wilms_tumour	pfam_FH2_Formin,pfam_FH3_dom,pfam_GTPase-bd,superfamily_ARM-type_fold,smart_FH2_Formin,prints_Wilms_tumour	-	no_errors	FMNL2	HGNC	ENSG00000157827	tier1	-	-	28	0	0.00	78	13	14.29	71	0	0.00	120	30	20.00
CD86	0	genome.wustl.edu	37	3	121822505	121822505	+	Missense_Mutation	SNP	G	G	C			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	3	121822505	121822505	G	C	SNP	CD86	ENST00000330540	human	ensembl	74_37	+1	known	missense	c.211	p.G71R	0.603	pfam_Ig_V-set,smart_Ig_sub,smart_Ig_V-set_subgr,pfscan_Ig-like_dom	pfam_Ig_V-set,smart_Ig_sub,smart_Ig_V-set_subgr,pfscan_Ig-like_dom	-	no_errors	CD86	HGNC	ENSG00000114013	tier1	-	-	74	0	0.00	49	21	30.00	102	0	0.00	70	24	25.53
OTOA	0	genome.wustl.edu	37	16	21702929	21702929	+	Silent	SNP	C	C	T			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	16	21702929	21702929	C	T	SNP	OTOA	ENST00000286149	human	ensembl	74_37	+1	known	silent	c.660	p.Y220	0.567	NULL	NULL	-	no_errors	OTOA	HGNC	ENSG00000155719	tier1	rs139292090	GMAF=0.0005	54	0	0.00	22	23	51.11	70	0	0.00	61	31	33.70
SLC19A1	0	genome.wustl.edu	37	21	46935022	46935022	+	Silent	SNP	A	A	G			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	21	46935022	46935022	A	G	SNP	SLC19A1	ENST00000380010	human	ensembl	74_37	-1	putative	silent	c.1338	p.H446	0.000	pirsf_Folate_carrier	pfam_Folate_carrier,superfamily_MFS_dom_general_subst_transpt,pirsf_Folate_carrier,tigrfam_Folate_carrier	-	no_errors	SLC19A1	HGNC	ENSG00000173638	tier1	-	-	18	0	0.00	29	11	27.50	40	0	0.00	18	16	47.06
ZNF182	0	genome.wustl.edu	37	X	47842772	47842772	+	Missense_Mutation	SNP	G	G	T			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	X	47842772	47842772	G	T	SNP	ZNF182	ENST00000305127	human	ensembl	74_37	-1	known	missense	c.112	p.Q38K	0.877	pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,pfscan_Krueppel-associated_box	pfam_Znf_C2H2,pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZNF182	HGNC	ENSG00000147118	tier1	-	-	70	0	0.00	62	24	27.91	76	0	0.00	47	19	28.79
MMP26	0	genome.wustl.edu	37	11	5013310	5013310	+	Missense_Mutation	SNP	T	T	C			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	11	5013310	5013310	T	C	SNP	MMP26	ENST00000300762	human	ensembl	74_37	+1	known	missense	c.712	p.F238L	0.898	pfam_Pept_M10_metallopeptidase,smart_Peptidase_Metallo	pfam_Pept_M10_metallopeptidase,superfamily_Peptidoglycan-bd-like,smart_Peptidase_Metallo,prints_Pept_M10A	-	no_errors	MMP26	HGNC	ENSG00000167346	tier1	-	-	35	0	0.00	32	9	21.95	98	0	0.00	43	7	14.00
GRHL2	0	genome.wustl.edu	37	8	102570802	102570802	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	8	102570802	102570802	C	T	SNP	GRHL2	ENST00000251808	human	ensembl	74_37	+1	known	missense	c.440	p.S147F	0.803	NULL	pfam_CP2	-	no_errors	GRHL2	HGNC	ENSG00000083307	tier1	-	-	37	0	0.00	15	19	54.29	64	0	0.00	31	23	42.59
PCDHA7	0	genome.wustl.edu	37	5	140214891	140214891	+	Missense_Mutation	SNP	T	T	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	5	140214891	140214891	T	A	SNP	PCDHA7	ENST00000525929	human	ensembl	74_37	+1	known	missense	c.923	p.M308K	0.079	pfam_Cadherin,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin	pfam_Cadherin,pfam_Cadherin_N,superfamily_Cadherin-like,smart_Cadherin,prints_Cadherin,pfscan_Cadherin	-	no_errors	PCDHA7	HGNC	ENSG00000204963	tier1	-	-	55	0	0.00	22	6	21.43	56	0	0.00	32	6	15.79
ABCA3	0	genome.wustl.edu	37	16	2329036	2329036	+	Silent	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	16	2329036	2329036	G	A	SNP	ABCA3	ENST00000301732	human	ensembl	74_37	-1	known	silent	c.4455	p.G1485	0.995	pfam_ABC_transporter-like,superfamily_P-loop_NTPase,smart_AAA+_ATPase,pfscan_ABC_transporter-like	pfam_ABC_transporter-like,superfamily_P-loop_NTPase,smart_AAA+_ATPase,pfscan_ABC_transporter-like	-	no_errors	ABCA3	HGNC	ENSG00000167972	tier1	-	-	94	0	0.00	106	58	34.73	16	0	0.00	15	15	50.00
FMNL2	0	genome.wustl.edu	37	2	153475623	153475623	+	Silent	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	2	153475623	153475623	G	A	SNP	FMNL2	ENST00000288670	human	ensembl	74_37	+1	known	silent	c.1578	p.L526	0.733	NULL	pfam_FH2_Formin,pfam_FH3_dom,pfam_GTPase-bd,superfamily_ARM-type_fold,smart_FH2_Formin,prints_Wilms_tumour	-	no_errors	FMNL2	HGNC	ENSG00000157827	tier1	-	-	30	0	0.00	114	23	16.79	54	0	0.00	100	21	17.21
MYH6	0	genome.wustl.edu	37	14	23853824	23853824	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	14	23853824	23853824	G	A	SNP	MYH6	ENST00000356287	human	ensembl	74_37	-1	known	missense	c.5392	p.R1798W	1.000	pfam_Myosin_tail	pfam_Myosin_tail,pfam_Myosin_head_motor_dom,pfam_Myosin_N,superfamily_P-loop_NTPase,superfamily_Prefoldin,smart_Myosin_head_motor_dom,pfscan_IQ_motif_EF-hand-BS,prints_Myosin_head_motor_dom	-	no_errors	MYH6	HGNC	ENSG00000197616	tier1	-	-	33	0	0.00	58	35	37.63	21	0	0.00	14	8	34.78
POT1	0	genome.wustl.edu	37	7	124493077	124493077	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	7	124493077	124493077	C	T	SNP	POT1	ENST00000357628	human	ensembl	74_37	-1	known	missense	c.818	p.R273Q	1.000	superfamily_-bd_OB-fold	pfam_Telomer_end-bd_POT1/Cdc13,superfamily_-bd_OB-fold,smart_Telomer_end-bd_POT1/Cdc13	-	no_errors	POT1	HGNC	ENSG00000128513	tier1	-	-	108	0	0.00	67	12	15.19	105	0	0.00	95	16	14.41
WNK3	0	genome.wustl.edu	37	X	54319436	54319436	+	Missense_Mutation	SNP	A	A	T			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	X	54319436	54319436	A	T	SNP	WNK3	ENST00000354646	human	ensembl	74_37	-1	known	missense	c.1922	p.I641N	0.410	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Kinase_OSR1/WNK_CCT,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	WNK3	HGNC	ENSG00000196632	tier1	-	-	113	0	0.00	74	13	14.94	104	0	0.00	100	21	17.36
FMNL2	0	genome.wustl.edu	37	2	153475589	153475589	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	2	153475589	153475589	G	A	SNP	FMNL2	ENST00000288670	human	ensembl	74_37	+1	known	missense	c.1544	p.G515E	0.991	prints_Wilms_tumour	pfam_FH2_Formin,pfam_FH3_dom,pfam_GTPase-bd,superfamily_ARM-type_fold,smart_FH2_Formin,prints_Wilms_tumour	-	no_errors	FMNL2	HGNC	ENSG00000157827	tier1	-	-	32	0	0.00	107	17	13.71	64	0	0.00	124	28	18.42
CHRM2	0	genome.wustl.edu	37	7	136700328	136700328	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	7	136700328	136700328	G	A	SNP	CHRM2	ENST00000320658	human	ensembl	74_37	+1	known	missense	c.716	p.R239K	0.862	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Musac_Ach_M2_rcpt	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Musac_Ach_M2_rcpt,prints_Musac_Ach_rcpt,prints_GPCR_Rhodpsn	-	no_errors	CHRM2	HGNC	ENSG00000181072	tier1	-	-	24	0	0.00	30	10	25.00	106	0	0.00	63	51	44.74
LOC100131825	0	genome.wustl.edu	37	1	159170734	159170734	+	R	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	1	159170734	159170734	G	A	SNP	LOC100131825	ENST00000415675	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.123	-	-	-	no_errors	CTA-134P22.2	Clone_based_vega_gene	ENSG00000225670	tier1	-	-	49	0	0.00	42	22	34.38	32	0	0.00	19	11	36.67
ZIM2	0	genome.wustl.edu	37	19	57301291	57301291	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	T	T	T	-	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	19	57301291	57301291	T	-	DEL	ZIM2	ENST00000221722	human	ensembl	74_37	-1	known	frame_shift_del	c.426	p.E143fs	0.000	NULL	pfam_Krueppel-associated_box,pfam_Znf_C2H2,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	ZIM2	HGNC	ENSG00000269699	tier1			37	0	0.00	76	16	17.39	58	0	0.00	114	20	14.93
CABP2	0	genome.wustl.edu	37	11	67288529	67288529	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	11	67288529	67288529	C	T	SNP	CABP2	ENST00000294288	human	ensembl	74_37	-1	known	missense	c.346	p.E116K	1.000	NULL	pfam_EF_hand_dom,smart_EF_hand_dom,pfscan_EF_hand_dom	-	no_errors	CABP2	HGNC	ENSG00000167791	tier1	rs140767804	-	35	0	0.00	25	25	50.00	17	0	0.00	8	5	38.46
FHDC1	0	genome.wustl.edu	37	4	153875437	153875437	+	Missense_Mutation	SNP	G	G	A			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	4	153875437	153875437	G	A	SNP	FHDC1	ENST00000260008	human	ensembl	74_37	+1	known	missense	c.629	p.R210Q	0.960	pfam_FH2_Formin,smart_FH2_Formin	pfam_FH2_Formin,smart_FH2_Formin	-	no_errors	FHDC1	HGNC	ENSG00000137460	tier1	-	-	28	0	0.00	3	24	88.89	64	0	0.00	9	32	78.05
SEC16A	0	genome.wustl.edu	37	9	139360765	139360765	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	G	G	G	-	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	9	139360765	139360765	G	-	DEL	SEC16A	ENST00000313050	human	ensembl	74_37	-1	known	frame_shift_del	c.4079	p.A1360fs	0.006	NULL	NULL	-	no_errors	SEC16A	HGNC	ENSG00000148396	tier1			59	0	0.00	85	35	29.17	5	0	0.00	4	3	42.86
DKK1	0	genome.wustl.edu	37	10	54074610	54074610	+	R	SNP	C	C	T			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	10	54074610	54074610	C	T	SNP	DKK1	ENST00000467359	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.002	-	-	-	no_errors	DKK1	HGNC	ENSG00000107984	tier1	-	-	48	0	0.00	42	5	10.64	90	0	0.00	66	5	7.04
USP7	0	genome.wustl.edu	37	16	8988658	8988658	+	Missense_Mutation	SNP	C	C	T			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	16	8988658	8988658	C	T	SNP	USP7	ENST00000344836	human	ensembl	74_37	-1	known	missense	c.3094	p.E1032K	1.000	NULL	pfam_Peptidase_C19/C67,pfam_MATH,pfam_USP7_ICP0-binding_dom,superfamily_TRAF-like,smart_MATH,pfscan_MATH,pfscan_Peptidase_C19/C67	-	no_errors	USP7	HGNC	ENSG00000187555	tier1	-	-	23	0	0.00	59	10	14.49	34	0	0.00	51	5	8.93
DNM1P51	0	genome.wustl.edu	37	15	84954198	84954212	+	R	DEL	ATGGGCATGCTGACG	ATGGGCATGCTGACG	-			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	ATGGGCATGCTGACG	ATGGGCATGCTGACG					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	15	84954198	84954212	ATGGGCATGCTGACG	-	DEL	DNM1P51	ENST00000558801	human	ensembl	74_37	-1	known	rna	NULL	NULL	1.000:0.996:0.997:0.997:0.990:0.993:1.000:1.000:1.000:0.991:0.992:0.989:0.996:0.997:1.000	-	-	-	no_errors	DNM1P51	HGNC	ENSG00000235370	tier1			1	0	0.00	3	0	0.00	1	0	0.00	3	0	0.00
ENSG00000221704	0	genome.wustl.edu	37	2	236480576	236480577	+	R	INS	-	-	TGTGTGTGTG			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	2	236480576	236480577	-	TGTGTGTGTG	INS	ENSG00000221704	ENST00000408777	human	ensembl	74_37	+1	novel	rna	NULL	NULL	0.083:0.055	-	-	-	no_errors	AC012305.1	Clone_based_ensembl_gene	ENSG00000221704	tier1			0	0	0.00	0	0	0.00	0	0	0.00	0	0	0.00
LOR	0	genome.wustl.edu	37	1	153233991	153233992	+	In_Frame_Ins	INS	-	-	CTCTGGCGGCGG			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	1	153233991	153233992	-	CTCTGGCGGCGG	INS	LOR	ENST00000368742	human	ensembl	74_37	+1	known	in_frame_ins	c.566_567	p.193in_frame_insGSGG	0.014:0.200	NULL	NULL	-	no_errors	LOR	HGNC	ENSG00000203782	tier1			2	0	0.00	3	0	0.00	2	0	0.00	3	0	0.00
SEPT5	0	genome.wustl.edu	37	22	19706405	19706474	+	Splice_Site	DEL	GGTCCCCGTCCCCGCGCGCCACGGCCCGCCAGCGCCTAGGCTCAGCCCTTCCCTCCGCAGCGGCCTCGCA	GGTCCCCGTCCCCGCGCGCCACGGCCCGCCAGCGCCTAGGCTCAGCCCTTCCCTCCGCAGCGGCCTCGCA	-			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	GGTCCCCGTCCCCGCGCGCCACGGCCCGCCAGCGCCTAGGCTCAGCCCTTCCCTCCGCAGCGGCCTCGCA	GGTCCCCGTCCCCGCGCGCCACGGCCCGCCAGCGCCTAGGCTCAGCCCTTCCCTCCGCAGCGGCCTCGCA					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	22	19706405	19706474	GGTCCCCGTCCCCGCGCGCCACGGCCCGCCAGCGCCTAGGCTCAGCCCTTCCCTCCGCAGCGGCCTCGCA	-	DEL	SEPT5	ENST00000490204	human	ensembl	74_37	+1	putative	splice_site_del	c.NULL	NULL	0.001:0.001:0.000:0.000:0.000:0.000:0.000:0.001:0.000:0.000:0.001:0.000:0.228:0.234:0.241:0.322:0.327:0.699:0.694:0.703:0.739:0.769:0.806:0.810:0.791:0.694:0.664:0.665:0.662:0.840:0.858:0.920:0.932:0.929:0.905:0.868:0.689:0.525:0.473:0.458:0.371:0.369:0.365:0.319:0.270:0.205:0.118:0.062:0.038:0.026:0.037:0.153:0.410:0.429:0.415:0.344:0.328:0.109:0.017:0.008:0.013:0.016:0.014:0.010:0.028:0.026:0.027:0.003:0.000:0.000	-	-	-	no_errors	SEPT5	HGNC	ENSG00000184702	tier1			2	0	0.00	0	0	0.00	2	0	0.00	0	0	0.00
LOC642361	0	genome.wustl.edu	37	10	81586763	81586764	+	R	INS	-	-	TCGCCTCGCC			TCGA-DX-AB2F-01A-11D-A387-09	TCGA-DX-AB2F-10A-01D-A38A-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1dbf015e-3809-436e-b7c4-d2b40266bd0f	b9ce481f-768d-40b6-aa4a-b571e5069c27	10	81586763	81586764	-	TCGCCTCGCC	INS	LOC642361	ENST00000605920	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.302:0.319	-	-	-	no_errors	RP11-182L21.6	Clone_based_vega_gene	ENSG00000272447	tier1			2	0	0.00	6	2	25.00	2	0	0.00	6	2	25.00