Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
KCNQ5	0	genome.wustl.edu	37	6	73904416	73904416	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	6	73904416	73904416	C	T	SNP	KCNQ5	ENST00000402622	human	ensembl	74_37	+1	known	missense	c.2108	p.T703M	1.000	NULL	pfam_K_chnl_volt-dep_KCNQ_C,pfam_Ion_trans_dom,pfam_2pore_dom_K_chnl_dom,prints_K_chnl_volt-dep_KCNQ,prints_K_chnl	-	no_errors	KCNQ5	HGNC	ENSG00000185760	tier1	-	-	17	0	0.00	26	6	18.75	76	1	1.30	81	15	15.62
PLCB1	0	genome.wustl.edu	37	20	8665641	8665641	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	20	8665641	8665641	C	T	SNP	PLCB1	ENST00000338037	human	ensembl	74_37	+1	known	missense	c.925	p.P309S	1.000	pirsf_PLC-beta,pfam_PLipase_C_EF-hand-like	pirsf_PLC-beta,pfam_PLC-beta_C,pfam_PLipase_C_PInositol-sp_X_dom,pfam_PLipase_C_Pinositol-sp_Y,pfam_PLipase_C_EF-hand-like,superfamily_PLC-like_Pdiesterase_TIM-brl,superfamily_C2_dom,smart_PLipase_C_PInositol-sp_X_dom,smart_PLipase_C_Pinositol-sp_Y,smart_C2_dom,prints_Pinositol_PLipase_C,pfscan_C2_dom,pfscan_PLipase_C_PInositol-sp_X_dom,pfscan_PLipase_C_Pinositol-sp_Y	-	no_errors	PLCB1	HGNC	ENSG00000182621	tier1	-	-	58	0	0.00	36	20	35.71	134	0	0.00	57	31	35.23
WDFY2	0	genome.wustl.edu	37	13	52332390	52332390	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	13	52332390	52332390	C	G	SNP	WDFY2	ENST00000298125	human	ensembl	74_37	+1	known	missense	c.1127	p.A376G	0.993	pfam_WD40_repeat,superfamily_WD40_repeat_dom,smart_WD40_repeat,pfscan_WD40_repeat,pfscan_WD40_repeat_dom	pfam_WD40_repeat,pfam_Znf_FYVE,superfamily_WD40_repeat_dom,superfamily_Znf_FYVE_PHD,smart_WD40_repeat,smart_Znf_FYVE,pfscan_Znf_FYVE-rel,pfscan_WD40_repeat,pfscan_WD40_repeat_dom,prints_G-protein_beta_WD-40_rep	-	no_errors	WDFY2	HGNC	ENSG00000139668	tier1	-	-	66	0	0.00	24	21	46.67	82	0	0.00	46	41	47.13
MAP2K4	0	genome.wustl.edu	37	17	12032516	12032516	+	Missense_Mutation	SNP	A	A	G			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	17	12032516	12032516	A	G	SNP	MAP2K4	ENST00000415385	human	ensembl	74_37	+1	known	missense	c.985	p.T329A	1.000	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	MAP2K4	HGNC	ENSG00000065559	tier1	-	-	46	0	0.00	24	19	44.19	60	0	0.00	19	14	42.42
OR4C3	0	genome.wustl.edu	37	11	48347059	48347059	+	Silent	SNP	T	T	G			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	11	48347059	48347059	T	G	SNP	OR4C3	ENST00000319856	human	ensembl	74_37	+1	known	silent	c.567	p.L189	0.003	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR4C3	HGNC	ENSG00000176547	tier1	-	-	112	0	0.00	74	16	17.78	146	0	0.00	110	29	20.86
EHBP1L1	0	genome.wustl.edu	37	11	65348685	65348685	+	Missense_Mutation	SNP	C	C	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	11	65348685	65348685	C	A	SNP	EHBP1L1	ENST00000309295	human	ensembl	74_37	+1	known	missense	c.707	p.A236D	0.998	NULL	pfam_DUF3585,pfam_CH-domain,pfam_CAMSAP_CH,superfamily_CH-domain,smart_CH-domain,pfscan_CH-domain	-	no_errors	EHBP1L1	HGNC	ENSG00000173442	tier1	-	-	15	0	0.00	17	36	67.92	56	0	0.00	41	79	65.83
SLC6A3	0	genome.wustl.edu	37	5	1432617	1432617	+	Silent	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	5	1432617	1432617	G	A	SNP	SLC6A3	ENST00000270349	human	ensembl	74_37	-1	known	silent	c.615	p.N205	0.989	pfam_Na/ntran_symport,pfscan_Na/ntran_symport	pfam_Na/ntran_symport,pfscan_Na/ntran_symport,prints_Na/ntran_symport,prints_Na/ntran_symport_dopamine	-	no_errors	SLC6A3	HGNC	ENSG00000142319	tier1	-	-	39	0	0.00	34	7	17.07	74	0	0.00	68	17	19.77
EHBP1L1	0	genome.wustl.edu	37	11	65348684	65348684	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	11	65348684	65348684	G	A	SNP	EHBP1L1	ENST00000309295	human	ensembl	74_37	+1	known	missense	c.706	p.A236T	0.987	NULL	pfam_DUF3585,pfam_CH-domain,pfam_CAMSAP_CH,superfamily_CH-domain,smart_CH-domain,pfscan_CH-domain	-	no_errors	EHBP1L1	HGNC	ENSG00000173442	tier1	-	-	14	0	0.00	18	37	67.27	56	0	0.00	42	79	65.29
KIAA1524	0	genome.wustl.edu	37	3	108273288	108273288	+	Missense_Mutation	SNP	A	A	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	3	108273288	108273288	A	T	SNP	KIAA1524	ENST00000295746	human	ensembl	74_37	-1	known	missense	c.2259	p.D753E	1.000	NULL	superfamily_ARM-type_fold	-	no_errors	KIAA1524	HGNC	ENSG00000163507	tier1	-	-	57	0	0.00	18	10	35.71	90	0	0.00	37	47	55.95
GRM3	0	genome.wustl.edu	37	7	86394618	86394618	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	7	86394618	86394618	G	A	SNP	GRM3	ENST00000361669	human	ensembl	74_37	+1	known	missense	c.157	p.G53R	1.000	superfamily_Peripla_BP_I,prints_GPCR_3_mtglu_rcpt_3	pfam_ANF_lig-bd_rcpt,pfam_GPCR_3_C,pfam_GPCR_3_9-Cys_dom,superfamily_Peripla_BP_I,pfscan_GPCR_3_C,prints_GPCR_3,prints_GPCR_3_mtglu_rcpt_3,prints_GPCR_3_mtglu_rcpt,prints_GPCR_3_mtglu_rcpt_2,prints_GPCR_3_GABA_rcpt_B	-	no_errors	GRM3	HGNC	ENSG00000198822	tier1	-	-	30	0	0.00	17	13	43.33	119	0	0.00	69	66	48.53
MARK1	0	genome.wustl.edu	37	1	220825491	220825491	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	1	220825491	220825491	G	A	SNP	MARK1	ENST00000366917	human	ensembl	74_37	+1	known	missense	c.1735	p.G579S	1.000	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_KA1_dom,superfamily_Kinase-like_dom,superfamily_KA1/Ssp2_C,superfamily_UBA-like,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,smart_UBA/transl_elong_EF1B_N_euk,prints_Ser-Thr/Tyr_kinase_cat_dom,pfscan_UBA/transl_elong_EF1B_N_euk,pfscan_Prot_kinase_dom	-	no_errors	MARK1	HGNC	ENSG00000116141	tier1	-	-	60	0	0.00	47	20	29.85	122	0	0.00	106	66	38.37
COL18A1	0	genome.wustl.edu	37	21	46909414	46909414	+	Silent	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	21	46909414	46909414	G	A	SNP	COL18A1	ENST00000359759	human	ensembl	74_37	+1	known	silent	c.3183	p.V1061	0.000	pfam_Collagen	pfam_Collagenase_NC10/endostatin,pfam_DUF959_COL18_N,pfam_Collagen,pfam_Frizzled_dom,superfamily_C-type_lectin_fold,superfamily_ConA-like_lec_gl_sf,superfamily_Frizzled_dom,smart_Frizzled_dom,smart_Laminin_G,pfscan_Frizzled_dom	-	no_errors	COL18A1	HGNC	ENSG00000182871	tier1	-	-	71	0	0.00	52	27	34.18	10	0	0.00	11	6	35.29
DCHS1	0	genome.wustl.edu	37	11	6651257	6651257	+	Missense_Mutation	SNP	C	C	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	11	6651257	6651257	C	T	SNP	DCHS1	ENST00000299441	human	ensembl	74_37	-1	known	missense	c.4768	p.G1590S	0.997	pfam_Cadherin,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin	pfam_Cadherin,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin	-	no_errors	DCHS1	HGNC	ENSG00000166341	tier1	-	-	43	0	0.00	37	18	32.73	22	0	0.00	19	7	26.92
TRIM64B	0	genome.wustl.edu	37	11	89603886	89603886	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	11	89603886	89603886	C	G	SNP	TRIM64B	ENST00000329862	human	ensembl	74_37	-1	known	missense	c.1253	p.S418T	0.277	pfam_SPRY_rcpt,superfamily_ConA-like_lec_gl_sf,smart_SPla/RYanodine_receptor_subgr,pfscan_B30.2/SPRY,prints_Butyrophylin	pfam_SPRY_rcpt,pfam_Znf_B-box,superfamily_ConA-like_lec_gl_sf,smart_Znf_RING,smart_Znf_B-box,smart_SPla/RYanodine_receptor_subgr,pfscan_B30.2/SPRY,pfscan_Znf_B-box,pfscan_Znf_RING,prints_Butyrophylin	-	no_errors	TRIM64B	HGNC	ENSG00000189253	tier1	-	-	244	0	0.00	387	41	9.58	74	0	0.00	160	18	10.11
CD244	0	genome.wustl.edu	37	1	160832438	160832438	+	Silent	SNP	G	G	C			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	1	160832438	160832438	G	C	SNP	CD244	ENST00000368033	human	ensembl	74_37	-1	known	silent	c.30	p.L10	0.007	NULL	pfam_NK_rcpt_2B4_Ig_dom,pfscan_Ig-like_dom	-	no_errors	CD244	HGNC	ENSG00000122223	tier1	-	-	50	0	0.00	34	53	60.92	117	0	0.00	59	78	56.12
PIP	0	genome.wustl.edu	37	7	142829269	142829269	+	Silent	SNP	C	C	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	7	142829269	142829269	C	T	SNP	PIP	ENST00000291009	human	ensembl	74_37	+1	known	silent	c.60	p.C20	0.887	pfam_SV_autoAg,pirsf_SV_autoAg	pfam_SV_autoAg,pirsf_SV_autoAg	-	no_errors	PIP	HGNC	ENSG00000159763	tier1	-	-	42	0	0.00	18	14	43.75	61	0	0.00	41	19	31.15
MYO10	0	genome.wustl.edu	37	5	16766285	16766285	+	Missense_Mutation	SNP	T	T	G			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	5	16766285	16766285	T	G	SNP	MYO10	ENST00000513610	human	ensembl	74_37	-1	known	missense	c.1083	p.L361F	0.998	pfam_Myosin_head_motor_dom,superfamily_P-loop_NTPase,smart_Myosin_head_motor_dom	pfam_Myosin_head_motor_dom,pfam_MyTH4_dom,pfam_Pleckstrin_homology,pfam_FERM_central,pfam_IQ_motif_EF-hand-BS,pfam_Ras-assoc,superfamily_P-loop_NTPase,superfamily_FERM_central,smart_Myosin_head_motor_dom,smart_IQ_motif_EF-hand-BS,smart_Pleckstrin_homology,smart_MyTH4_dom,smart_Band_41_domain,pfscan_FERM_domain,pfscan_IQ_motif_EF-hand-BS,pfscan_MyTH4_dom,pfscan_Pleckstrin_homology,prints_Myosin_head_motor_dom	-	no_errors	MYO10	HGNC	ENSG00000145555	tier1	-	-	26	0	0.00	21	6	22.22	43	0	0.00	33	40	54.79
KDR	0	genome.wustl.edu	37	4	55981139	55981139	+	Missense_Mutation	SNP	A	A	G			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	4	55981139	55981139	A	G	SNP	KDR	ENST00000263923	human	ensembl	74_37	-1	known	missense	c.560	p.I187T	0.901	smart_Ig_sub,prints_VEGFR2_rcpt	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Ig_I-set,pfam_Prot_kinase_dom,pfam_Ig_V-set,pfam_Immunoglobulin,pfam_CD80_C2-set,superfamily_Kinase-like_dom,smart_Ig_sub,smart_Ig_sub2,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom,prints_VEGFR2_rcpt	-	no_errors	KDR	HGNC	ENSG00000128052	tier1	-	-	38	0	0.00	18	14	43.75	133	0	0.00	78	52	39.69
LOC100286922	0	genome.wustl.edu	37	2	234663608	234663608	+	R	SNP	A	A	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	2	234663608	234663608	A	T	SNP	LOC100286922	ENST00000450901	human	ensembl	74_37	-1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	AC114812.5	Clone_based_vega_gene	ENSG00000178836	tier1	-	-	50	0	0.00	25	15	37.50	59	0	0.00	49	31	38.75
EFHC2	0	genome.wustl.edu	37	X	44008133	44008133	+	Missense_Mutation	SNP	C	C	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	X	44008133	44008133	C	A	SNP	EFHC2	ENST00000420999	human	ensembl	74_37	-1	known	missense	c.2158	p.D720Y	1.000	NULL	pfam_DUF1126,smart_Uncharacterised_DM10,pfscan_EF_hand_dom	-	no_errors	EFHC2	HGNC	ENSG00000183690	tier1	-	-	65	0	0.00	27	31	53.45	179	0	0.00	91	103	53.09
KRTAP19-5	0	genome.wustl.edu	37	21	31874391	31874391	+	Silent	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	21	31874391	31874391	G	A	SNP	KRTAP19-5	ENST00000334151	human	ensembl	74_37	-1	known	silent	c.18	p.N6	0.353	pfam_KRTAP_type6/8/16/19/20	pfam_KRTAP_type6/8/16/19/20	-	no_errors	KRTAP19-5	HGNC	ENSG00000186977	tier1	-	-	126	0	0.00	46	47	50.54	49	0	0.00	38	20	34.48
HARS2	0	genome.wustl.edu	37	5	140073605	140073605	+	Missense_Mutation	SNP	C	C	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	5	140073605	140073605	C	A	SNP	HARS2	ENST00000230771	human	ensembl	74_37	+1	known	missense	c.269	p.A90E	1.000	pfam_aa-tR-synt_IIb_cons-dom,pirsf_HisRS/HisZ,pfscan_aa-tR-synth_II,tigrfam_His-tR-ligase	pfam_aa-tR-synt_IIb_cons-dom,pfam_Anticodon-bd,superfamily_Anticodon-bd,pirsf_HisRS/HisZ,pfscan_aa-tR-synth_II,tigrfam_His-tR-ligase	-	no_errors	HARS2	HGNC	ENSG00000112855	tier1	-	-	71	0	0.00	56	9	13.85	134	0	0.00	117	29	19.86
CYP11B2	0	genome.wustl.edu	37	8	143994865	143994865	+	Silent	SNP	T	T	C			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	8	143994865	143994865	T	C	SNP	CYP11B2	ENST00000323110	human	ensembl	74_37	-1	known	silent	c.957	p.T319	0.000	pfam_Cyt_P450,superfamily_Cyt_P450,prints_Cyt_P450_E_grp-I,prints_Cyt_P450	pfam_Cyt_P450,superfamily_Cyt_P450,prints_Cyt_P450_mitochondrial,prints_Cyt_P450_E_grp-I,prints_Cyt_P450_E_grp-IV,prints_Cyt_P450,prints_Cyt_P450_B	-	no_errors	CYP11B2	HGNC	ENSG00000179142	tier1	-	-	60	0	0.00	33	21	38.89	4	0	0.00	11	7	38.89
FREM1	0	genome.wustl.edu	37	9	14842509	14842509	+	Missense_Mutation	SNP	A	A	C			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	9	14842509	14842509	A	C	SNP	FREM1	ENST00000380881	human	ensembl	74_37	-1	known	missense	c.1546	p.L516V	1.000	NULL	pfam_C-type_lectin,pfam_Calx_beta,superfamily_C-type_lectin_fold,superfamily_Cadherin-like,smart_C-type_lectin,pfscan_C-type_lectin	-	no_errors	FREM1	HGNC	ENSG00000164946	tier1	-	-	36	0	0.00	25	12	32.43	115	0	0.00	75	50	40.00
KANSL1	0	genome.wustl.edu	37	17	44116420	44116420	+	Nonsense_Mutation	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	17	44116420	44116420	G	A	SNP	KANSL1	ENST00000262419	human	ensembl	74_37	-1	known	nonsense	c.2365	p.R789*	1.000	NULL	NULL	-	no_errors	KANSL1	HGNC	ENSG00000120071	tier1	-	-	73	0	0.00	35	32	47.76	94	0	0.00	69	55	44.00
SERPINB10	0	genome.wustl.edu	37	18	61587038	61587038	+	Missense_Mutation	SNP	T	T	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	18	61587038	61587038	T	A	SNP	SERPINB10	ENST00000238508	human	ensembl	74_37	+1	known	missense	c.389	p.M130K	0.999	pfam_Serpin_dom,superfamily_Serpin_dom,smart_Serpin_dom	pfam_Serpin_dom,superfamily_Serpin_dom,smart_Serpin_dom	-	no_errors	SERPINB10	HGNC	ENSG00000242550	tier1	-	-	31	0	0.00	25	7	21.88	81	0	0.00	73	16	17.98
HOXC5	0	genome.wustl.edu	37	12	54426956	54426956	+	Missense_Mutation	SNP	C	C	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	12	54426956	54426956	C	A	SNP	HOXC5	ENST00000312492	human	ensembl	74_37	+1	known	missense	c.50	p.P17H	1.000	NULL	pfam_Homeobox_dom,superfamily_Homeodomain-like,smart_Homeobox_dom,pfscan_Homeobox_dom,prints_Homeobox_metazoa,prints_Homeobox_antennapedia	-	no_errors	HOXC5	HGNC	ENSG00000172789	tier1	-	-	49	0	0.00	33	24	42.11	73	0	0.00	35	39	52.70
EPHA3	0	genome.wustl.edu	37	3	89478261	89478261	+	Missense_Mutation	SNP	C	C	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	3	89478261	89478261	C	A	SNP	EPHA3	ENST00000336596	human	ensembl	74_37	+1	known	missense	c.2080	p.P694T	1.000	pirsf_Tyr_kinase_ephrin_rcpt,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pirsf_Tyr_kinase_ephrin_rcpt,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Ephrin_rcpt_lig-bd_dom,pfam_Prot_kinase_dom,pfam_Fibronectin_type3,pfam_SAM_2,pfam_SAM_type1,pfam_Tyr-kin_ephrin_A/B_rcpt-like,superfamily_Galactose-bd-like,superfamily_Kinase-like_dom,superfamily_Fibronectin_type3,superfamily_SAM/pointed,superfamily_Growth_fac_rcpt_N_dom,smart_Ephrin_rcpt_lig-bd_dom,smart_Fibronectin_type3,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,smart_SAM,prints_Ser-Thr/Tyr_kinase_cat_dom,pfscan_Fibronectin_type3,pfscan_SAM,pfscan_Prot_kinase_dom	-	no_errors	EPHA3	HGNC	ENSG00000044524	tier1	-	-	49	0	0.00	19	9	32.14	81	0	0.00	74	18	19.57
FRYL	0	genome.wustl.edu	37	4	48551622	48551622	+	Missense_Mutation	SNP	T	T	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	4	48551622	48551622	T	A	SNP	FRYL	ENST00000358350	human	ensembl	74_37	-1	known	missense	c.4652	p.Y1551F	1.000	superfamily_ARM-type_fold	superfamily_ARM-type_fold	-	no_errors	FRYL	HGNC	ENSG00000075539	tier1	-	-	35	0	0.00	22	7	24.14	77	0	0.00	22	15	40.54
PTCHD3	0	genome.wustl.edu	37	10	27702287	27702287	+	Missense_Mutation	SNP	G	G	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	10	27702287	27702287	G	T	SNP	PTCHD3	ENST00000438700	human	ensembl	74_37	-1	known	missense	c.893	p.T298N	0.255	pfam_Patched	pfam_Patched,pfscan_SSD	-	no_errors	PTCHD3	HGNC	ENSG00000182077	tier1	-	-	66	0	0.00	33	26	44.07	46	0	0.00	27	29	51.79
CX3CR1	0	genome.wustl.edu	37	3	39307683	39307683	+	Silent	SNP	G	G	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	3	39307683	39307683	G	T	SNP	CX3CR1	ENST00000358309	human	ensembl	74_37	-1	known	silent	c.414	p.T138	0.000	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Chemokine_rcpt	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,pfscan_GPCR_Rhodpsn_7TM,prints_Chemokine_CX3CR1,prints_GPCR_Rhodpsn,prints_Chemokine_rcpt,prints_Duffy_chemokine_rcpt,prints_Chemokine_CXCR4	-	no_errors	CX3CR1	HGNC	ENSG00000168329	tier1	-	-	25	0	0.00	12	8	40.00	108	0	0.00	88	31	26.05
GRM3	0	genome.wustl.edu	37	7	86394619	86394619	+	Missense_Mutation	SNP	G	G	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	7	86394619	86394619	G	T	SNP	GRM3	ENST00000361669	human	ensembl	74_37	+1	known	missense	c.158	p.G53V	1.000	superfamily_Peripla_BP_I,prints_GPCR_3_mtglu_rcpt_3	pfam_ANF_lig-bd_rcpt,pfam_GPCR_3_C,pfam_GPCR_3_9-Cys_dom,superfamily_Peripla_BP_I,pfscan_GPCR_3_C,prints_GPCR_3,prints_GPCR_3_mtglu_rcpt_3,prints_GPCR_3_mtglu_rcpt,prints_GPCR_3_mtglu_rcpt_2,prints_GPCR_3_GABA_rcpt_B	-	no_errors	GRM3	HGNC	ENSG00000198822	tier1	-	-	29	0	0.00	17	13	43.33	120	0	0.00	68	66	48.89
PSME4	0	genome.wustl.edu	37	2	54152727	54152727	+	Silent	SNP	C	C	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	2	54152727	54152727	C	T	SNP	PSME4	ENST00000404125	human	ensembl	74_37	-1	known	silent	c.1758	p.L586	0.958	superfamily_ARM-type_fold	pfam_DUF3437,superfamily_ARM-type_fold	-	no_errors	PSME4	HGNC	ENSG00000068878	tier1	-	-	86	0	0.00	31	26	45.61	159	0	0.00	76	64	45.71
LOC100128714	0	genome.wustl.edu	37	15	26260644	26260644	+	R	SNP	C	C	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	15	26260644	26260644	C	T	SNP	LOC100128714	ENST00000383019	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	RP11-1084I9.1	Clone_based_vega_gene	ENSG00000206187	tier1	-	-	40	0	0.00	21	20	48.78	68	0	0.00	31	23	42.59
KCNT2	0	genome.wustl.edu	37	1	196250098	196250098	+	Silent	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	1	196250098	196250098	G	A	SNP	KCNT2	ENST00000294725	human	ensembl	74_37	-1	known	silent	c.2802	p.D934	1.000	NULL	pfam_K_chnl_Ca-activ_BK_asu,pfam_2pore_dom_K_chnl_dom	-	no_errors	KCNT2	HGNC	ENSG00000162687	tier1	-	-	50	0	0.00	23	30	56.60	93	0	0.00	45	70	60.87
PPP3R2	0	genome.wustl.edu	37	9	104356954	104356954	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	9	104356954	104356954	C	G	SNP	PPP3R2	ENST00000374806	human	ensembl	74_37	-1	known	missense	c.259	p.V87L	1.000	pfscan_EF_hand_dom	pfam_EF_hand_dom,smart_EF_hand_dom,pfscan_EF_hand_dom,prints_Recoverin	-	no_errors	PPP3R2	HGNC	ENSG00000188386	tier1	-	-	51	0	0.00	33	16	32.65	69	0	0.00	21	29	58.00
P1L3	0	genome.wustl.edu	37	X	92928275	92928275	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	X	92928275	92928275	G	A	SNP	P1L3	ENST00000373079	human	ensembl	74_37	-1	known	missense	c.29	p.S10L	0.049	NULL	pfam_P_family	-	no_errors	P1L3	HGNC	ENSG00000186310	tier1	-	-	77	0	0.00	30	35	53.85	78	0	0.00	50	32	39.02
PTTG1	0	genome.wustl.edu	37	5	159854773	159854773	+	Missense_Mutation	SNP	T	T	G			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	5	159854773	159854773	T	G	SNP	PTTG1	ENST00000352433	human	ensembl	74_37	+1	known	missense	c.422	p.L141W	1.000	pfam_Securin_separation_inhibitor	pfam_Securin_separation_inhibitor	-	no_errors	PTTG1	HGNC	ENSG00000164611	tier1	-	-	64	0	0.00	12	8	40.00	34	0	0.00	14	3	17.65
IGDCC4	0	genome.wustl.edu	37	15	65674297	65674297	+	R	SNP	C	C	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	15	65674297	65674297	C	T	SNP	IGDCC4	ENST00000558048	human	ensembl	74_37	-1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	IGDCC4	HGNC	ENSG00000103742	tier1	-	-	22	0	0.00	14	9	39.13	141	0	0.00	71	66	48.18
V2	0	genome.wustl.edu	37	11	20070457	20070457	+	Silent	SNP	C	C	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	11	20070457	20070457	C	A	SNP	V2	ENST00000396087	human	ensembl	74_37	+1	known	silent	c.4155	p.L1385	0.999	NULL	pfam_CH-domain,superfamily_CH-domain,superfamily_P-loop_NTPase,smart_CH-domain,smart_AAA+_ATPase,pfscan_CH-domain	-	no_errors	V2	HGNC	ENSG00000166833	tier1	-	-	56	0	0.00	26	30	53.57	62	0	0.00	45	42	48.28
MALAT1	0	genome.wustl.edu	37	11	65269611	65269612	+	R	INS	-	-	TTTCC			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	-	-	-	TTTCC	-	-	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	11	65269611	65269612	-	TTTCC	INS	MALAT1	ENST00000534336	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000:0.000	-	-	-	no_errors	MALAT1	HGNC	ENSG00000251562	tier1			131	0	0.00	163	36	18.09	131	0	0.00	163	36	18.09
ARID1A	0	genome.wustl.edu	37	1	27097647	27097647	+	Missense_Mutation	SNP	A	A	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	1	27097647	27097647	A	T	SNP	ARID1A	ENST00000324856	human	ensembl	74_37	+1	known	missense	c.3236	p.N1079I	1.000	pfam_ARID/BRIGHT_D-bd,superfamily_ARID/BRIGHT_D-bd,smart_ARID/BRIGHT_D-bd,pfscan_ARID/BRIGHT_D-bd	pfam_DUF3518,pfam_ARID/BRIGHT_D-bd,superfamily_ARID/BRIGHT_D-bd,superfamily_ARM-type_fold,smart_ARID/BRIGHT_D-bd,pfscan_ARID/BRIGHT_D-bd	-	no_errors	ARID1A	HGNC	ENSG00000117713	tier1	-	-	46	0	0.00	2	32	94.12	118	0	0.00	5	46	90.20
ARL4D	0	genome.wustl.edu	37	17	41477526	41477526	+	Silent	SNP	A	A	G			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	17	41477526	41477526	A	G	SNP	ARL4D	ENST00000320033	human	ensembl	74_37	+1	known	silent	c.426	p.A142	0.207	pfam_Small_GTPase_ARF/SAR,pfam_Small_GTPase,pfam_SRP_receptor_beta_su,pfam_EF_GTP-bd_dom,superfamily_P-loop_NTPase,smart_Small_GTPase_ARF,smart_Small_GTPase_SAR1,smart_Small_GTPase_Ras,smart_Small_GTPase_Rab_type,prints_Small_GTPase_ARF/SAR,tigrfam_Small_GTP-bd_dom	pfam_Small_GTPase_ARF/SAR,pfam_Small_GTPase,pfam_MIRO-like,pfam_SRP_receptor_beta_su,pfam_EF_GTP-bd_dom,pfam_Gtr1_RagA,superfamily_P-loop_NTPase,smart_Small_GTPase_ARF,smart_Small_GTPase_SAR1,smart_Small_GTPase_Ras,smart_Small_GTPase_Rab_type,prints_Small_GTPase_ARF/SAR,prints_Small_GTPase,tigrfam_Small_GTP-bd_dom	-	no_errors	ARL4D	HGNC	ENSG00000175906	tier1	-	-	17	0	0.00	15	10	40.00	13	0	0.00	7	4	36.36
C14orf39	0	genome.wustl.edu	37	14	60950421	60950421	+	Missense_Mutation	SNP	T	T	C			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	14	60950421	60950421	T	C	SNP	C14orf39	ENST00000321731	human	ensembl	74_37	-1	known	missense	c.221	p.D74G	0.996	NULL	NULL	-	no_errors	C14orf39	HGNC	ENSG00000179008	tier1	-	-	62	0	0.00	6	26	81.25	131	0	0.00	6	66	91.67
CD33	0	genome.wustl.edu	37	19	51729106	51729106	+	Missense_Mutation	SNP	G	G	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	19	51729106	51729106	G	T	SNP	CD33	ENST00000262262	human	ensembl	74_37	+1	known	missense	c.466	p.G156C	0.004	pfam_Immunoglobulin,pfam_CD80_C2-set,smart_Ig_sub,pfscan_Ig-like_dom	pfam_Ig_V-set,pfam_Immunoglobulin,pfam_CD80_C2-set,smart_Ig_sub,pfscan_Ig-like_dom	-	no_errors	CD33	HGNC	ENSG00000105383	tier1	-	-	18	0	0.00	3	18	85.71	36	0	0.00	2	32	94.12
CLASRP	0	genome.wustl.edu	37	19	45561081	45561081	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	19	45561081	45561081	G	A	SNP	CLASRP	ENST00000221455	human	ensembl	74_37	+1	known	missense	c.538	p.E180K	0.983	NULL	pfam_SWAP_N_domain	-	no_errors	CLASRP	HGNC	ENSG00000104859	tier1	-	-	35	0	0.00	6	15	71.43	72	0	0.00	2	34	87.18
CSMD2	0	genome.wustl.edu	37	1	34383726	34383726	+	Missense_Mutation	SNP	C	C	G			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	1	34383726	34383726	C	G	SNP	CSMD2	ENST00000373381	human	ensembl	74_37	-1	known	missense	c.889	p.E297Q	1.000	pfam_CUB_dom,superfamily_CUB_dom,smart_CUB_dom,pfscan_CUB_dom	pfam_CUB_dom,pfam_Sushi_SCR_CCP,superfamily_CUB_dom,superfamily_Sushi_SCR_CCP,smart_CUB_dom,smart_Sushi_SCR_CCP,pfscan_CUB_dom,pfscan_Sushi_SCR_CCP	-	no_errors	CSMD2	HGNC	ENSG00000121904	tier1	-	-	32	0	0.00	1	19	95.00	96	0	0.00	3	52	94.55
GARNL3	0	genome.wustl.edu	37	9	130005414	130005414	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	9	130005414	130005414	G	A	SNP	GARNL3	ENST00000429629	human	ensembl	74_37	+1	known	missense	c.29	p.G10E	1.000	NULL	NULL	-	no_errors	GARNL3	HGNC	ENSG00000136895	tier1	-	-	56	0	0.00	2	18	90.00	82	0	0.00	1	41	97.62
LRRC37A6P	0	genome.wustl.edu	37	10	27536666	27536666	+	R	SNP	C	C	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	10	27536666	27536666	C	T	SNP	LRRC37A6P	ENST00000284414	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.000	-	-	-	no_errors	LRRC37A6P	HGNC	ENSG00000230445	tier1	-	-	38	0	0.00	17	17	50.00	16	0	0.00	8	14	63.64
PTPN23	0	genome.wustl.edu	37	3	47452009	47452009	+	Silent	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	3	47452009	47452009	G	A	SNP	PTPN23	ENST00000265562	human	ensembl	74_37	+1	known	silent	c.2721	p.P907	0.066	NULL	pfam_BRO1_dom,pfam_Tyr_Pase_rcpt/non-rcpt,smart_Tyr_Pase_rcpt/non-rcpt,smart_Tyr_Pase_cat,pfscan_BRO1_dom,pfscan_Tyr/Dual-sp_Pase,pfscan_Tyr_Pase_rcpt/non-rcpt,prints_Tyr_Pase_rcpt/non-rcpt	-	no_errors	PTPN23	HGNC	ENSG00000076201	tier1	rs150118207	-	9	0	0.00	5	5	50.00	8	0	0.00	9	6	27.27
SRRM1	0	genome.wustl.edu	37	1	24969812	24969812	+	R	SNP	G	G	C			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	1	24969812	24969812	G	C	SNP	SRRM1	ENST00000466910	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.994	-	-	-	no_errors	SRRM1	HGNC	ENSG00000133226	tier1	-	-	52	0	0.00	6	19	76.00	23	0	0.00	1	7	87.50
CKAP5	0	genome.wustl.edu	37	11	46774244	46774244	+	Missense_Mutation	SNP	G	G	A			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	11	46774244	46774244	G	A	SNP	CKAP5	ENST00000415402	human	ensembl	74_37	-1	known	missense	c.5074	p.L1692F	1.000	superfamily_ARM-type_fold	pfam_CLASP_N_dom,pfam_HEAT,superfamily_ARM-type_fold,superfamily_Homing_endonucl,pfscan_HEAT_type_2	-	no_errors	CKAP5	HGNC	ENSG00000175216	tier1	-	-	29	0	0.00	10	7	41.18	122	2	1.61	72	53	42.06
BHLHA9	0	genome.wustl.edu	37	17	1174545	1174545	+	Missense_Mutation	SNP	A	A	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	17	1174545	1174545	A	T	SNP	BHLHA9	ENST00000391429	human	ensembl	74_37	+1	known	missense	c.688	p.M230L	0.081	NULL	pfam_bHLH_dom,superfamily_bHLH_dom,smart_bHLH_dom,pfscan_bHLH_dom	-	no_errors	BHLHA9	HGNC	ENSG00000205899	tier1	-	-	29	0	0.00	9	8	47.06	0	0	0.00	0	0	0.00
CROCCP2	0	genome.wustl.edu	37	1	16952377	16952377	+	R	SNP	C	C	T			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	1	16952377	16952377	C	T	SNP	CROCCP2	ENST00000412962	human	ensembl	74_37	-1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	CROCCP2	HGNC	ENSG00000215908	tier1	rs9658928	-	92	0	0.00	52	5	8.77	0	0	0.00	3	0	0.00
ENSG00000221684	0	genome.wustl.edu	37	X	70979260	70979261	+	R	DEL	GC	GC	-			TCGA-K1-A42X-01A-11D-A24N-09	TCGA-K1-A42X-11A-11D-A24N-09	GC	GC					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	347468ce-6cf1-46ba-8d49-c9627f57b1b1	8bee70d0-af1d-40fb-9152-522822710a6e	X	70979260	70979261	GC	-	DEL	ENSG00000221684	ENST00000408757	human	ensembl	74_37	-1	novel	rna	NULL	NULL	0.000:0.000	-	-	-	no_errors	BX276092.1	Clone_based_ensembl_gene	ENSG00000221684	tier1			27	0	0.00	19	5	20.83	0	0	0.00	1	0	0.00