Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
KIAA1549	0	genome.wustl.edu	37	7	138601629	138601629	+	Missense_Mutation	SNP	C	C	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	7	138601629	138601629	C	A	SNP	KIAA1549	ENST00000422774	human	ensembl	74_37	-1	known	missense	c.2743	p.A915S	0.000	NULL	NULL	-	no_errors	KIAA1549	HGNC	ENSG00000122778	tier1	-	-	34	0	0.00	22	7	24.14	39	0	0.00	35	13	27.08
KLF8	0	genome.wustl.edu	37	X	56276720	56276720	+	Missense_Mutation	SNP	A	A	G			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	X	56276720	56276720	A	G	SNP	KLF8	ENST00000468660	human	ensembl	74_37	+1	known	missense	c.64	p.M22V	0.978	NULL	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	KLF8	HGNC	ENSG00000102349	tier1	-	-	21	0	0.00	23	16	41.03	63	0	0.00	27	38	58.46
WDFY3	0	genome.wustl.edu	37	4	85625498	85625498	+	Missense_Mutation	SNP	C	C	G			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	4	85625498	85625498	C	G	SNP	WDFY3	ENST00000295888	human	ensembl	74_37	-1	known	missense	c.8435	p.R2812T	0.997	pfam_BEACH_dom,superfamily_BEACH_dom,pfscan_BEACH_dom	pfam_BEACH_dom,pfam_Znf_FYVE,pfam_WD40_repeat,superfamily_BEACH_dom,superfamily_WD40_repeat_dom,superfamily_Znf_FYVE_PHD,superfamily_ConA-like_lec_gl_sf,superfamily_Cyclin-like,superfamily_ARM-type_fold,smart_WD40_repeat,smart_Znf_FYVE,pfscan_BEACH_dom,pfscan_Znf_FYVE-rel,pfscan_WD40_repeat,pfscan_WD40_repeat_dom	-	no_errors	WDFY3	HGNC	ENSG00000163625	tier1	-	-	67	0	0.00	38	18	32.14	143	0	0.00	48	22	31.43
ENSG00000244227	0	genome.wustl.edu	37	3	167621135	167621135	+	R	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	3	167621135	167621135	C	T	SNP	ENSG00000244227	ENST00000459923	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.003	-	-	-	no_errors	RP11-298O21.5	Clone_based_vega_gene	ENSG00000244227	tier1	-	-	55	0	0.00	57	7	10.94	127	0	0.00	63	16	20.25
PAPD5	0	genome.wustl.edu	37	16	50265294	50265294	+	R	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	16	50265294	50265294	C	T	SNP	PAPD5	ENST00000573002	human	ensembl	74_37	+1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	PAPD5	HGNC	ENSG00000121274	tier1	-	-	67	0	0.00	38	20	34.48	36	0	0.00	20	5	20.00
B4GALNT3	0	genome.wustl.edu	37	12	665772	665772	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	12	665772	665772	G	A	SNP	B4GALNT3	ENST00000266383	human	ensembl	74_37	+1	known	missense	c.2120	p.G707D	0.894	pfam_Chond_Galc	pfam_PA14,pfam_Chond_Galc,smart_PA14	-	no_errors	B4GALNT3	HGNC	ENSG00000139044	tier1	-	-	94	0	0.00	54	15	21.74	75	0	0.00	34	12	26.09
CSMD2	0	genome.wustl.edu	37	1	34312507	34312507	+	Silent	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	1	34312507	34312507	G	A	SNP	CSMD2	ENST00000373381	human	ensembl	74_37	-1	known	silent	c.1011	p.R337	0.212	pfam_CUB_dom,superfamily_CUB_dom,smart_CUB_dom,pfscan_CUB_dom	pfam_CUB_dom,pfam_Sushi_SCR_CCP,superfamily_CUB_dom,superfamily_Sushi_SCR_CCP,smart_CUB_dom,smart_Sushi_SCR_CCP,pfscan_CUB_dom,pfscan_Sushi_SCR_CCP	-	no_errors	CSMD2	HGNC	ENSG00000121904	tier1	rs143306375	-	36	0	0.00	27	7	20.59	44	0	0.00	27	6	18.18
CCDC169-SOHLH2	0	genome.wustl.edu	37	13	36765961	36765961	+	Silent	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	13	36765961	36765961	C	T	SNP	CCDC169-SOHLH2	ENST00000511166	human	ensembl	74_37	-1	known	silent	c.732	p.L244	0.000	NULL	pfam_bHLH_dom,superfamily_bHLH_dom,smart_bHLH_dom,pfscan_bHLH_dom	-	no_errors	CCDC169-SOHLH2	HGNC	ENSG00000250709	tier1	-	-	81	0	0.00	67	11	14.10	122	0	0.00	50	20	28.57
TMLHE	0	genome.wustl.edu	37	X	154736707	154736707	+	Missense_Mutation	SNP	G	G	C			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	X	154736707	154736707	G	C	SNP	TMLHE	ENST00000334398	human	ensembl	74_37	-1	known	missense	c.847	p.Q283E	0.996	pfam_Taurine_dOase,tigrfam_Trimethyllysine_dOase	pfam_Taurine_dOase,pfam_DUF971,tigrfam_Trimethyllysine_dOase	-	no_errors	TMLHE	HGNC	ENSG00000185973	tier1	-	-	37	0	0.00	30	21	41.18	46	0	0.00	24	19	44.19
DLG4	0	genome.wustl.edu	37	17	7094060	7094060	+	Silent	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	17	7094060	7094060	G	A	SNP	DLG4	ENST00000399510	human	ensembl	74_37	-1	known	silent	c.2271	p.P757	1.000	pirsf_M-assoc_guanylate_kinase,superfamily_P-loop_NTPase	pirsf_M-assoc_guanylate_kinase,pfam_GK/Ca_channel_bsu,pfam_PDZ,pfam_PDZ_assoc,pfam_MAGUK_PEST_N,pfam_SH3_domain,pfam_SH3_2,pfam_L27_1,superfamily_P-loop_NTPase,superfamily_SH3_domain,superfamily_PDZ,smart_PDZ,smart_SH3_domain,smart_GK/Ca_channel_bsu,pfscan_PDZ,pfscan_SH3_domain,pfscan_Guanylate_kin-like	-	no_errors	DLG4	HGNC	ENSG00000132535	tier1	-	-	72	0	0.00	56	25	30.86	86	0	0.00	52	25	32.47
KNTC1	0	genome.wustl.edu	37	12	123036012	123036012	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	12	123036012	123036012	G	A	SNP	KNTC1	ENST00000333479	human	ensembl	74_37	+1	known	missense	c.1138	p.E380K	1.000	NULL	pfam_RZZ-complex_KNTC1/ROD_C,superfamily_Quino_amine_DH_bsu,superfamily_WD40_repeat_dom,superfamily_PAH	-	no_errors	KNTC1	HGNC	ENSG00000184445	tier1	-	-	73	0	0.00	58	17	22.67	101	0	0.00	36	8	18.18
JAKMIP3	0	genome.wustl.edu	37	10	133963537	133963537	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	10	133963537	133963537	G	A	SNP	JAKMIP3	ENST00000298622	human	ensembl	74_37	+1	known	missense	c.1999	p.A667T	1.000	NULL	NULL	-	no_errors	JAKMIP3	HGNC	ENSG00000188385	tier1	rs199769239	GMAF=0.0005	20	0	0.00	22	7	24.14	100	0	0.00	29	10	25.64
ACCS	0	genome.wustl.edu	37	11	44104824	44104824	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	11	44104824	44104824	G	A	SNP	ACCS	ENST00000263776	human	ensembl	74_37	+1	known	missense	c.1217	p.R406H	0.642	pfam_Aminotransferase_I/II,superfamily_PyrdxlP-dep_Trfase	pfam_Aminotransferase_I/II,superfamily_PyrdxlP-dep_Trfase	-	no_errors	ACCS	HGNC	ENSG00000110455	tier1	rs138481594	GMAF=0.0005	81	0	0.00	58	6	9.38	144	0	0.00	109	17	13.49
CCNDBP1	0	genome.wustl.edu	37	15	43483857	43483857	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	15	43483857	43483857	G	A	SNP	CCNDBP1	ENST00000300213	human	ensembl	74_37	+1	known	missense	c.844	p.D282N	1.000	NULL	NULL	-	no_errors	CCNDBP1	HGNC	ENSG00000166946	tier1	-	-	19	0	0.00	22	6	21.43	107	0	0.00	62	11	15.07
TBX5	0	genome.wustl.edu	37	12	114793771	114793771	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	12	114793771	114793771	G	A	SNP	TBX5	ENST00000310346	human	ensembl	74_37	-1	known	missense	c.1123	p.R375W	1.000	NULL	pfam_TF_T-box,superfamily_p53-like_TF_D-bd,smart_TF_T-box,pfscan_TF_T-box,prints_TF_T-box	-	no_errors	TBX5	HGNC	ENSG00000089225	tier1	-	-	54	0	0.00	31	10	24.39	20	0	0.00	11	2	15.38
ADCY2	0	genome.wustl.edu	37	5	7724664	7724664	+	Missense_Mutation	SNP	G	G	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	5	7724664	7724664	G	T	SNP	ADCY2	ENST00000338316	human	ensembl	74_37	+1	known	missense	c.1710	p.W570C	1.000	pfam_Adenylate_cyclase-like	pfam_A/G_cyclase,pfam_Adenylate_cyclase-like,superfamily_A/G_cyclase,smart_A/G_cyclase,pfscan_A/G_cyclase	-	no_errors	ADCY2	HGNC	ENSG00000078295	tier1	-	-	49	0	0.00	46	18	28.12	111	0	0.00	73	19	20.65
OR6T1	0	genome.wustl.edu	37	11	123814023	123814023	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	11	123814023	123814023	C	T	SNP	OR6T1	ENST00000321252	human	ensembl	74_37	-1	known	missense	c.523	p.D175N	0.887	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM,prints_Olfact_rcpt,prints_GPCR_Rhodpsn	-	no_errors	OR6T1	HGNC	ENSG00000181499	tier1	rs149839618	GMAF=0.0005	41	0	0.00	24	6	20.00	120	0	0.00	59	22	27.16
ENSG00000220256	0	genome.wustl.edu	37	2	240702074	240702074	+	Nonsense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	2	240702074	240702074	C	T	SNP	ENSG00000220256	ENST00000407524	human	ensembl	74_37	+1	putative	nonsense	c.124	p.Q42*	0.009	NULL	NULL	-	no_errors	AC093802.1	Clone_based_vega_gene	ENSG00000220256	tier1	-	-	114	0	0.00	78	17	17.89	41	0	0.00	20	4	16.67
TMPRSS15	0	genome.wustl.edu	37	21	19744557	19744557	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	21	19744557	19744557	C	T	SNP	TMPRSS15	ENST00000284885	human	ensembl	74_37	-1	known	missense	c.617	p.G206E	1.000	pfam_LDrepeatLR_classA_rpt,superfamily_LDrepeatLR_classA_rpt,smart_LDrepeatLR_classA_rpt,pfscan_LDrepeatLR_classA_rpt,prints_LDrepeatLR_classA_rpt	pfam_Peptidase_S1,pfam_CUB_dom,pfam_MAM_dom,pfam_SEA_dom,pfam_LDrepeatLR_classA_rpt,pfam_Peptidase_S1A_nudel,pfam_SRCR,superfamily_Trypsin-like_Pept_dom,superfamily_ConA-like_lec_gl_sf,superfamily_CUB_dom,superfamily_LDrepeatLR_classA_rpt,superfamily_Srcr_rcpt-rel,smart_SEA_dom,smart_LDrepeatLR_classA_rpt,smart_CUB_dom,smart_MAM_dom,smart_Srcr_rcpt-rel,smart_Peptidase_S1,pfscan_CUB_dom,pfscan_LDrepeatLR_classA_rpt,pfscan_MAM_dom,pfscan_SEA_dom,pfscan_SRCR,pfscan_Peptidase_S1,prints_Peptidase_S1A,prints_LDrepeatLR_classA_rpt	-	no_errors	TMPRSS15	HGNC	ENSG00000154646	tier1	-	-	25	0	0.00	31	5	13.89	108	0	0.00	84	11	11.58
PPP3CC	0	genome.wustl.edu	37	8	22380189	22380189	+	Missense_Mutation	SNP	C	C	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	8	22380189	22380189	C	A	SNP	PPP3CC	ENST00000240139	human	ensembl	74_37	+1	known	missense	c.870	p.S290R	1.000	smart_Ser/Thr-sp_prot-phosphatase	pfam_PEstase_dom,smart_Ser/Thr-sp_prot-phosphatase,prints_Ser/Thr-sp_prot-phosphatase	-	no_errors	PPP3CC	HGNC	ENSG00000120910	tier1	-	-	31	0	0.00	26	17	39.53	100	0	0.00	33	19	36.54
CDH12	0	genome.wustl.edu	37	5	21765143	21765143	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	5	21765143	21765143	G	A	SNP	CDH12	ENST00000382254	human	ensembl	74_37	-1	known	missense	c.1459	p.P487S	1.000	superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin	pfam_Cadherin,pfam_Cadherin_cytoplasmic-dom,superfamily_Cadherin-like,smart_Cadherin,pfscan_Cadherin,prints_Cadherin	-	no_errors	CDH12	HGNC	ENSG00000154162	tier1	-	-	47	0	0.00	113	10	8.13	97	0	0.00	97	12	11.01
RRN3P2	0	genome.wustl.edu	37	16	29088081	29088081	+	R	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	16	29088081	29088081	C	T	SNP	RRN3P2	ENST00000427965	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.995	-	-	-	no_errors	RRN3P2	HGNC	ENSG00000103472	tier1	-	-	98	0	0.00	99	41	29.29	40	0	0.00	16	9	36.00
DDX58	0	genome.wustl.edu	37	9	32500870	32500870	+	Silent	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	9	32500870	32500870	G	A	SNP	DDX58	ENST00000379883	human	ensembl	74_37	-1	known	silent	c.174	p.L58	0.070	superfamily_DEATH-like_dom	pfam_RIG-I_C-RD,pfam_D/R_helicase_DEAD/DEAH_N,pfam_Helicase/UvrB_dom,pfam_Helicase_C,superfamily_P-loop_NTPase,superfamily_DEATH-like_dom,smart_Helicase_ATP-bd,smart_Helicase_C,pfscan_Helicase_ATP-bd,pfscan_Helicase_C	-	no_errors	DDX58	HGNC	ENSG00000107201	tier1	-	-	48	0	0.00	65	15	18.75	132	0	0.00	107	42	28.19
SDK2	0	genome.wustl.edu	37	17	71415397	71415397	+	Silent	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	17	71415397	71415397	G	A	SNP	SDK2	ENST00000392650	human	ensembl	74_37	-1	known	silent	c.2094	p.I698	0.873	pfam_Fibronectin_type3,superfamily_Fibronectin_type3,smart_Fibronectin_type3,pfscan_Fibronectin_type3	pfam_Fibronectin_type3,pfam_Ig_I-set,pfam_Immunoglobulin,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	SDK2	HGNC	ENSG00000069188	tier1	-	-	51	0	0.00	50	11	18.03	39	0	0.00	36	7	16.28
AMPD3	0	genome.wustl.edu	37	11	10500123	10500123	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	11	10500123	10500123	C	T	SNP	AMPD3	ENST00000396553	human	ensembl	74_37	+1	known	missense	c.272	p.P91L	1.000	pirsf_AMP_deaminase	pfam_A/AMP_deaminase_dom,pirsf_AMP_deaminase,tigrfam_AMP_deaminase	-	no_errors	AMPD3	HGNC	ENSG00000133805	tier1	-	-	37	0	0.00	43	14	24.56	49	0	0.00	30	10	25.00
FLNC	0	genome.wustl.edu	37	7	128490862	128490862	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	7	128490862	128490862	G	A	SNP	FLNC	ENST00000325888	human	ensembl	74_37	+1	known	missense	c.5404	p.V1802M	1.000	pfam_Filamin/ABP280_repeat-like,superfamily_Ig_E-set,smart_Filamin,pfscan_Filamin/ABP280_repeat-like	pfam_Filamin/ABP280_repeat-like,pfam_CH-domain,superfamily_CH-domain,superfamily_Ig_E-set,smart_CH-domain,smart_Filamin,pfscan_CH-domain,pfscan_Filamin/ABP280_repeat-like	-	no_errors	FLNC	HGNC	ENSG00000128591	tier1	-	-	44	0	0.00	16	13	44.83	56	0	0.00	16	20	55.56
IFNW1	0	genome.wustl.edu	37	9	21141089	21141089	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	9	21141089	21141089	C	T	SNP	IFNW1	ENST00000380229	human	ensembl	74_37	-1	known	missense	c.481	p.D161N	0.019	pfam_Interferon_alpha/beta/delta,superfamily_4_helix_cytokine-like_core,smart_Interferon_alpha/beta/delta,prints_Interferon_alpha/beta/delta	pfam_Interferon_alpha/beta/delta,superfamily_4_helix_cytokine-like_core,smart_Interferon_alpha/beta/delta,prints_Interferon_alpha/beta/delta	-	no_errors	IFNW1	HGNC	ENSG00000177047	tier1	-	-	46	0	0.00	65	13	16.67	74	0	0.00	55	7	11.11
HAVCR1	0	genome.wustl.edu	37	5	156482233	156482233	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	5	156482233	156482233	C	T	SNP	HAVCR1	ENST00000425854	human	ensembl	74_37	-1	known	missense	c.358	p.V120I	0.000	smart_Ig_sub,pfscan_Ig-like_dom	pfam_Ig_V-set,smart_Ig_sub,pfscan_Ig-like_dom	-	no_errors	HAVCR1	HGNC	ENSG00000113249	tier1	-	-	44	0	0.00	36	9	20.00	75	0	0.00	34	12	26.09
PAFAH1B3	0	genome.wustl.edu	37	19	42804136	42804136	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	19	42804136	42804136	G	A	SNP	PAFAH1B3	ENST00000262890	human	ensembl	74_37	-1	known	missense	c.394	p.R132W	1.000	NULL	NULL	-	no_errors	PAFAH1B3	HGNC	ENSG00000079462	tier1	rs200814337	-	58	0	0.00	33	8	19.51	113	0	0.00	68	16	19.05
TP53	0	genome.wustl.edu	37	17	7577046	7577046	+	Nonsense_Mutation	SNP	C	C	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	17	7577046	7577046	C	A	SNP	TP53	ENST00000269305	human	ensembl	74_37	-1	known	nonsense	c.892	p.E298*	0.001	NULL	pfam_p53_D-bd,pfam_p53_tetrameristn,pfam_p53_transactivation_domain,superfamily_p53-like_TF_D-bd,superfamily_p53_tetrameristn,prints_p53_tumour_suppressor	-	no_errors	TP53	HGNC	ENSG00000141510	tier1	-	-	62	0	0.00	22	51	68.92	94	0	0.00	29	58	66.67
ARHGAP32	0	genome.wustl.edu	37	11	128934794	128934794	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	11	128934794	128934794	C	T	SNP	ARHGAP32	ENST00000310343	human	ensembl	74_37	-1	known	missense	c.662	p.R221H	1.000	pfam_Phox,superfamily_Phox	pfam_RhoGAP_dom,pfam_SH3_domain,pfam_SH3_2,pfam_Phox,superfamily_Rho_GTPase_activation_prot,superfamily_SH3_domain,superfamily_Phox,smart_SH3_domain,smart_RhoGAP_dom,pfscan_SH3_domain,pfscan_RhoGAP_dom	-	no_errors	ARHGAP32	HGNC	ENSG00000134909	tier1	-	-	62	0	0.00	52	10	16.13	99	0	0.00	66	9	12.00
SLC4A9	0	genome.wustl.edu	37	5	139751126	139751126	+	Missense_Mutation	SNP	C	C	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	5	139751126	139751126	C	A	SNP	SLC4A9	ENST00000230993	human	ensembl	74_37	+1	known	missense	c.2659	p.L887I	1.000	pfam_HCO3_transpt_C,tigrfam_HCO3_transpt_euk	pfam_HCO3_transpt_C,pfam_Band3_cytoplasmic_dom,superfamily_PTrfase/Anion_transptr,prints_HCO3_transpt_euk,prints_Na/HCO3_transpt,tigrfam_HCO3_transpt_euk	-	no_errors	SLC4A9	HGNC	ENSG00000113073	tier1	-	-	27	0	0.00	25	6	19.35	55	0	0.00	33	8	19.51
MYLK2	0	genome.wustl.edu	37	20	30418869	30418869	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	20	30418869	30418869	C	T	SNP	MYLK2	ENST00000375985	human	ensembl	74_37	+1	known	missense	c.1349	p.S450L	1.000	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	-	no_errors	MYLK2	HGNC	ENSG00000101306	tier1	-	-	84	0	0.00	159	32	16.67	97	0	0.00	145	33	18.54
RASGRF1	0	genome.wustl.edu	37	15	79350742	79350742	+	Silent	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	15	79350742	79350742	G	A	SNP	RASGRF1	ENST00000419573	human	ensembl	74_37	-1	known	silent	c.465	p.T155	0.009	NULL	pfam_RasGRF_CDC25,pfam_Ras-like_Gua-exchang_fac_N,pfam_DH-domain,pfam_Pleckstrin_homology,superfamily_Ras_GEF_dom,superfamily_DH-domain,smart_Pleckstrin_homology,smart_DH-domain,smart_Ras-like_Gua-exchang_fac_N,smart_RasGRF_CDC25,pfscan_IQ_motif_EF-hand-BS,pfscan_Pleckstrin_homology,pfscan_DH-domain,pfscan_RasGRF_CDC25,pfscan_Ras-like_Gua-exchang_fac_N	-	no_errors	RASGRF1	HGNC	ENSG00000058335	tier1	-	-	40	0	0.00	22	7	24.14	37	0	0.00	46	7	13.21
IGSF22	0	genome.wustl.edu	37	11	18729766	18729766	+	Silent	SNP	A	A	G			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	A	A	A	G	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	11	18729766	18729766	A	G	SNP	IGSF22	ENST00000513874	human	ensembl	74_37	-1	known	silent	c.3075	p.H1025	0.002	pfam_Ig_I-set,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	pfam_Ig_I-set,pfam_Fibronectin_type3,pfam_Immunoglobulin,superfamily_Fibronectin_type3,smart_Ig_sub,smart_Ig_sub2,smart_Fibronectin_type3,pfscan_Fibronectin_type3,pfscan_Ig-like_dom	-	no_errors	IGSF22	HGNC	ENSG00000179057	tier1	-	-	39	0	0.00	34	8	19.05	98	0	0.00	34	12	26.09
IKZF4	0	genome.wustl.edu	37	12	56427018	56427018	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	12	56427018	56427018	C	T	SNP	IKZF4	ENST00000262032	human	ensembl	74_37	+1	known	missense	c.910	p.H304Y	1.000	NULL	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	IKZF4	HGNC	ENSG00000123411	tier1	-	-	43	0	0.00	35	14	28.57	75	0	0.00	46	13	22.03
PTPN18	0	genome.wustl.edu	37	2	131128341	131128341	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	2	131128341	131128341	G	A	SNP	PTPN18	ENST00000175756	human	ensembl	74_37	+1	known	missense	c.820	p.A274T	0.001	pfam_Tyr_Pase_rcpt/non-rcpt,smart_Tyr_Pase_rcpt/non-rcpt,smart_Tyr_Pase_cat,pfscan_Tyr/Dual-sp_Pase,pfscan_Tyr_Pase_rcpt/non-rcpt,prints_Tyr_Pase_rcpt/non-rcpt	pfam_Tyr_Pase_rcpt/non-rcpt,smart_Tyr_Pase_rcpt/non-rcpt,smart_Tyr_Pase_cat,pfscan_Tyr/Dual-sp_Pase,pfscan_Tyr_Pase_rcpt/non-rcpt,prints_Tyr_Pase_rcpt/non-rcpt	-	no_errors	PTPN18	HGNC	ENSG00000072135	tier1	-	-	42	0	0.00	26	9	25.71	56	0	0.00	17	7	29.17
ENSG00000229481	0	genome.wustl.edu	37	19	38321666	38321666	+	R	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	19	38321666	38321666	G	A	SNP	ENSG00000229481	ENST00000443870	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.099	-	-	-	no_errors	CTD-2554C21.3	Clone_based_vega_gene	ENSG00000229481	tier1	-	-	42	0	0.00	36	5	12.20	87	0	0.00	39	5	11.36
ENSG00000267260	0	genome.wustl.edu	37	19	37266356	37266356	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	19	37266356	37266356	C	T	SNP	ENSG00000267260	ENST00000590750	human	ensembl	74_37	+1	putative	missense	c.202	p.R68C	0.029	NULL	NULL	-	no_errors	CTD-2162K18.4	Clone_based_vega_gene	ENSG00000267260	tier1	-	-	115	0	0.00	56	35	38.46	139	1	0.71	76	34	30.91
PAX6	0	genome.wustl.edu	37	11	31823240	31823240	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	11	31823240	31823240	G	A	SNP	PAX6	ENST00000379107	human	ensembl	74_37	-1	known	missense	c.268	p.P90S	1.000	pfam_Paired_dom,superfamily_Homeodomain-like,smart_Paired_dom,prints_Paired_dom,pfscan_Paired_dom	pfam_Paired_dom,pfam_Homeobox_dom,superfamily_Homeodomain-like,smart_Paired_dom,smart_Homeobox_dom,prints_Paired_dom,pfscan_Homeobox_dom,pfscan_Paired_dom	-	no_errors	PAX6	HGNC	ENSG00000007372	tier1	-	-	54	0	0.00	57	14	19.72	108	0	0.00	43	12	21.82
NCKAP1	0	genome.wustl.edu	37	2	183817934	183817934	+	Frame_Shift_Del	DEL	T	T	-			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	T	T	T	-	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	2	183817934	183817934	T	-	DEL	NCKAP1	ENST00000360982	human	ensembl	74_37	-1	known	frame_shift_del	c.2297	p.D766fs	1.000	pfam_Nck-associated_protein-1	pfam_Nck-associated_protein-1	-	no_errors	NCKAP1	HGNC	ENSG00000061676	tier1			66	0	0.00	62	17	21.52	120	0	0.00	58	13	18.31
HMBOX1	0	genome.wustl.edu	37	8	28909077	28909086	+	Frame_Shift_Del	DEL	GGATGCAAGC	GGATGCAAGC	-			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	GGATGCAAGC	GGATGCAAGC	GGATGCAAGC	-	GGATGCAAGC	GGATGCAAGC	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	8	28909077	28909086	GGATGCAAGC	-	DEL	HMBOX1	ENST00000355231	human	ensembl	74_37	+1	putative	frame_shift_del	c.1130_1139	p.R377fs	1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000:1.000	NULL	pfam_HNF-1_N,pfam_Homeobox_dom,superfamily_Lambda_D-bd_dom,superfamily_Homeodomain-like,smart_Homeobox_dom,pfscan_Homeobox_dom	-	no_errors	HMBOX1	HGNC	ENSG00000147421	tier1			117	0	0.00	58	8	12.12	117	0	0.00	58	8	12.12
NEB	0	genome.wustl.edu	37	2	152548372	152548377	+	Splice_Site	DEL	ACTTAC	ACTTAC	-			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	ACTTAC	ACTTAC	ACTTAC	-	ACTTAC	ACTTAC	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	2	152548372	152548377	ACTTAC	-	DEL	NEB	ENST00000397345	human	ensembl	74_37	-1	known	splice_site_del	c.2211+1_2211+1	e21+1	0.753:1.000:1.000:1.000:1.000:1.000	-	-	-	no_errors	NEB	HGNC	ENSG00000183091	tier1			137	0	0.00	64	30	31.91	137	0	0.00	64	30	31.91
ACOT11	0	genome.wustl.edu	37	1	55050380	55050380	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	1	55050380	55050380	C	T	SNP	ACOT11	ENST00000371316	human	ensembl	74_37	+1	known	missense	c.86	p.A29V	0.014	NULL	pfam_START_lipid-bd_dom,pfam_Thioestr_supf,smart_START_lipid-bd_dom,pfscan_START_lipid-bd_dom	-	no_errors	ACOT11	HGNC	ENSG00000162390	tier1	rs150203501	-	65	0	0.00	15	33	68.75	66	0	0.00	8	40	83.33
BCL9L	0	genome.wustl.edu	37	11	118771359	118771359	+	Silent	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	11	118771359	118771359	G	A	SNP	BCL9L	ENST00000334801	human	ensembl	74_37	-1	known	silent	c.3093	p.N1031	1.000	NULL	pfam_BCL9_beta-catenin-bd_dom	-	no_errors	BCL9L	HGNC	ENSG00000186174	tier1	-	-	24	0	0.00	7	15	68.18	51	1	1.92	7	22	75.86
CCDC88C	0	genome.wustl.edu	37	14	91744358	91744358	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	14	91744358	91744358	C	T	SNP	CCDC88C	ENST00000389857	human	ensembl	74_37	-1	known	missense	c.4966	p.V1656I	0.000	NULL	pfam_Hook-related_fam,superfamily_Prefoldin,superfamily_Fum_Rdtase/Succ_DH_flav-like_C	-	no_errors	CCDC88C	HGNC	ENSG00000015133	tier1	-	-	64	0	0.00	42	14	25.00	11	0	0.00	5	2	28.57
HDAC7	0	genome.wustl.edu	37	12	48189100	48189100	+	Missense_Mutation	SNP	G	G	C			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	12	48189100	48189100	G	C	SNP	HDAC7	ENST00000380610	human	ensembl	74_37	-1	known	missense	c.1202	p.S401C	0.883	pirsf_Histone_deAcase_II_euk	pfam_His_deacetylse_dom,pirsf_Histone_deAcase_II_euk,prints_His_deacetylse	-	no_errors	HDAC7	HGNC	ENSG00000061273	tier1	-	-	96	0	0.00	43	44	50.57	17	0	0.00	5	6	54.55
GRIN3A	0	genome.wustl.edu	37	9	104335644	104335644	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	9	104335644	104335644	C	T	SNP	GRIN3A	ENST00000361820	human	ensembl	74_37	-1	known	missense	c.3160	p.E1054K	1.000	NULL	pfam_Iontro_glu_rcpt,pfam_SBP_bac_3,pfam_Glu_rcpt_Glu/Gly-bd,superfamily_Peripla_BP_I,smart_Glu_rcpt_Glu/Gly-bd,smart_Iontro_glu_rcpt,prints_NMDA_rcpt	-	no_errors	GRIN3A	HGNC	ENSG00000198785	tier1	-	-	45	0	0.00	57	5	8.06	81	0	0.00	88	7	7.37
DH5	0	genome.wustl.edu	37	5	13922290	13922290	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	5	13922290	13922290	G	A	SNP	DH5	ENST00000265104	human	ensembl	74_37	-1	known	missense	c.586	p.R196C	0.152	NULL	pfam_Dynein_heavy_dom,pfam_Dynein_heavy_dom-1,pfam_Dynein_heavy_dom-2,pfam_ATPase_dyneun-rel_AAA,superfamily_P-loop_NTPase,smart_AAA+_ATPase	-	no_errors	DH5	HGNC	ENSG00000039139	tier1	rs200314274	-	60	0	0.00	89	9	9.18	53	0	0.00	55	5	8.33
MACF1	0	genome.wustl.edu	37	1	39823522	39823522	+	Missense_Mutation	SNP	A	A	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	1	39823522	39823522	A	T	SNP	MACF1	ENST00000317713	human	ensembl	74_37	+1	known	missense	c.5714	p.K1905M	0.999	smart_Spectrin/alpha-actinin	pfam_Spectrin_repeat,pfam_CH-domain,pfam_GAS2_dom,pfam_CAMSAP_CH,superfamily_CH-domain,superfamily_GAS2_dom,smart_CH-domain,smart_Spectrin/alpha-actinin,smart_EF_hand_dom,smart_GAS2_dom,pfscan_CH-domain,pfscan_EF_hand_dom	-	no_errors	MACF1	HGNC	ENSG00000127603	tier1	-	-	56	0	0.00	46	10	17.86	124	0	0.00	96	10	9.43
RASGRF1	0	genome.wustl.edu	37	15	79298606	79298606	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	15	79298606	79298606	C	T	SNP	RASGRF1	ENST00000419573	human	ensembl	74_37	-1	known	missense	c.2036	p.R679H	1.000	pfam_Ras-like_Gua-exchang_fac_N,superfamily_Ras_GEF_dom,smart_Ras-like_Gua-exchang_fac_N,pfscan_Ras-like_Gua-exchang_fac_N	pfam_RasGRF_CDC25,pfam_Ras-like_Gua-exchang_fac_N,pfam_DH-domain,pfam_Pleckstrin_homology,superfamily_Ras_GEF_dom,superfamily_DH-domain,smart_Pleckstrin_homology,smart_DH-domain,smart_Ras-like_Gua-exchang_fac_N,smart_RasGRF_CDC25,pfscan_IQ_motif_EF-hand-BS,pfscan_Pleckstrin_homology,pfscan_DH-domain,pfscan_RasGRF_CDC25,pfscan_Ras-like_Gua-exchang_fac_N	-	no_errors	RASGRF1	HGNC	ENSG00000058335	tier1	-	-	53	0	0.00	49	10	16.95	103	0	0.00	79	5	5.95
KIAA0947	0	genome.wustl.edu	37	5	5460964	5460964	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	5	5460964	5460964	G	A	SNP	KIAA0947	ENST00000296564	human	ensembl	74_37	+1	known	missense	c.1517	p.R506Q	0.000	NULL	superfamily_Vitellinogen_superhlx	-	no_errors	KIAA0947	HGNC	ENSG00000164151	tier1	-	-	31	0	0.00	55	10	15.38	107	0	0.00	111	10	8.26
IPO5	0	genome.wustl.edu	37	13	98655019	98655019	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	13	98655019	98655019	C	T	SNP	IPO5	ENST00000261574	human	ensembl	74_37	+1	known	missense	c.1369	p.H457Y	1.000	superfamily_ARM-type_fold	pfam_HEAT,superfamily_ARM-type_fold,pfscan_Importin-beta_N	-	no_errors	IPO5	HGNC	ENSG00000065150	tier1	-	-	11	0	0.00	12	10	45.45	124	2	1.59	38	16	29.63
FAM182B	0	genome.wustl.edu	37	20	25755864	25755864	+	Missense_Mutation	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	20	25755864	25755864	C	T	SNP	FAM182B	ENST00000376404	human	ensembl	74_37	-1	known	missense	c.83	p.G28E	0.317	NULL	NULL	-	no_errors	FAM182B	HGNC	ENSG00000175170	tier1	-	-	53	0	0.00	52	10	16.13	36	1	2.70	20	10	33.33
AGFG2	0	genome.wustl.edu	37	7	100163512	100163512	+	R	DEL	C	C	-			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	7	100163512	100163512	C	-	DEL	AGFG2	ENST00000474713	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.013	-	-	-	no_errors	AGFG2	HGNC	ENSG00000106351	tier1			28	0	0.00	38	4	9.52	6	0	0.00	8	0	0.00
CARD10	0	genome.wustl.edu	37	22	37904671	37904671	+	Frame_Shift_Del	DEL	C	C	-			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	22	37904671	37904671	C	-	DEL	CARD10	ENST00000251973	human	ensembl	74_37	-1	known	frame_shift_del	c.928	p.A310fs	0.999	NULL	pfam_CARD,superfamily_DEATH-like_dom,pfscan_CARD	-	no_errors	CARD10	HGNC	ENSG00000100065	tier1			16	0	0.00	22	2	8.33	0	0	0.00	6	0	0.00
ENSG00000260158	0	genome.wustl.edu	37	16	32822096	32822096	+	R	SNP	C	C	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	16	32822096	32822096	C	A	SNP	ENSG00000260158	ENST00000569859	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.676	-	-	-	no_errors	RP11-67H24.2	Clone_based_vega_gene	ENSG00000260158	tier1	-	-	10	0	0.00	14	12	46.15	0	0	0.00	0	0	0.00
FAM230A	0	genome.wustl.edu	37	22	20709096	20709096	+	Silent	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	22	20709096	20709096	C	T	SNP	FAM230A	ENST00000434783	human	ensembl	74_37	+1	known	silent	c.828	p.N276	0.029	superfamily_Kinase-like_dom	pfam_Ret-finger_pr-like_3_antisense,superfamily_Kinase-like_dom	-	no_errors	FAM230A	HGNC	ENSG00000188280	tier1	-	-	108	0	0.00	90	16	14.55	1	0	0.00	6	0	0.00
LINC00200	0	genome.wustl.edu	37	10	1205736	1205736	+	R	SNP	A	A	G			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	A	A					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	10	1205736	1205736	A	G	SNP	LINC00200	ENST00000425630	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.155	-	-	-	no_errors	LINC00200	HGNC	ENSG00000229205	tier1	rs60415666	-	18	0	0.00	14	5	26.32	2	0	0.00	0	0	0.00
ZNF358	0	genome.wustl.edu	37	19	7584581	7584581	+	Silent	SNP	C	C	T			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	19	7584581	7584581	C	T	SNP	ZNF358	ENST00000394341	human	ensembl	74_37	+1	known	silent	c.453	p.F151	1.000	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	ZNF358	HGNC	ENSG00000198816	tier1	-	-	22	0	0.00	31	8	20.51	0	0	0.00	1	0	0.00
RFPL4A	0	genome.wustl.edu	37	19	56274126	56274126	+	Missense_Mutation	SNP	G	G	A			TCGA-QQ-A5V9-01A-11D-A32I-09	TCGA-QQ-A5V9-11A-31D-A32I-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	1ae3de4e-4700-435a-add1-586224c5838b	f3212ce3-7a66-415a-9ef8-f1669ed8940e	19	56274126	56274126	G	A	SNP	RFPL4A	ENST00000434937	human	ensembl	74_37	+1	novel	missense	c.449	p.R150H	0.116	pfam_SPRY_rcpt,superfamily_ConA-like_lec_gl_sf,smart_SPla/RYanodine_receptor_subgr,prints_Butyrophylin,pfscan_B30.2/SPRY	pfam_RDM_domain_RFPL,pfam_SPRY_rcpt,superfamily_ConA-like_lec_gl_sf,smart_PRY,smart_SPla/RYanodine_receptor_subgr,prints_Butyrophylin,pfscan_B30.2/SPRY,pfscan_Znf_RING	-	no_errors	RFPL4A	HGNC	ENSG00000223638	tier1	-	-	185	1	0.53	132	17	11.41	97	0	0.00	86	2	2.27