Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	default_gene_name	gene_name_source	 ensembl_gene_id	tier	dbSNP	GMAF	n_ref_count	n_alt_count	normal_vaf	t_ref_count	t_alt_count	tumor_vaf	n_ref_count_val	n_alt_count_val	normal_vaf_val	t_ref_count_val	t_alt_count_val	tumor_vaf_val
ZNF890P	0	genome.wustl.edu	37	7	5161321	5161321	+	R	SNP	G	G	C			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	7	5161321	5161321	G	C	SNP	ZNF890P	ENST00000422060	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.001	-	-	-	no_errors	ZNF890P	HGNC	ENSG00000159904	tier1	-	-	92	0	0.00	152	44	22.45	69	0	0.00	84	26	23.64
ENSG00000219492	0	genome.wustl.edu	37	4	9385981	9385981	+	Silent	SNP	A	A	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	A	A	A	T	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	4	9385981	9385981	A	T	SNP	ENSG00000219492	ENST00000508324	human	ensembl	74_37	-1	novel	silent	c.663	p.T221	0.656	smart_Znf_C2H2-like,pfscan_Znf_C2H2	pfam_Krueppel-associated_box,superfamily_Krueppel-associated_box,smart_Krueppel-associated_box,smart_Znf_C2H2-like,pfscan_Znf_C2H2,pfscan_Krueppel-associated_box	-	no_errors	RP11-1396O13.13	Clone_based_vega_gene	ENSG00000219492	tier1	-	-	283	0	0.00	207	54	20.69	89	0	0.00	22	11	33.33
GALNT14	0	genome.wustl.edu	37	2	31168687	31168687	+	Missense_Mutation	SNP	G	G	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	2	31168687	31168687	G	A	SNP	GALNT14	ENST00000349752	human	ensembl	74_37	-1	known	missense	c.704	p.T235I	0.998	pfam_Glyco_trans_2	pfam_Glyco_trans_2,pfam_Ricin_B_lectin,superfamily_Ricin_B_lectin,smart_Ricin_B_lectin,pfscan_Ricin_B_lectin	-	no_errors	GALNT14	HGNC	ENSG00000158089	tier1	-	-	42	0	0.00	56	29	34.12	88	0	0.00	39	22	36.07
ZDBF2	0	genome.wustl.edu	37	2	207173469	207173469	+	Missense_Mutation	SNP	G	G	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	2	207173469	207173469	G	T	SNP	ZDBF2	ENST00000374423	human	ensembl	74_37	+1	known	missense	c.4217	p.G1406V	0.975	NULL	pfam_Znf_DBF,smart_Znf_DBF	-	no_errors	ZDBF2	HGNC	ENSG00000204186	tier1	-	-	39	0	0.00	115	39	25.16	120	0	0.00	87	36	29.27
DGKI	0	genome.wustl.edu	37	7	137080395	137080395	+	Silent	SNP	C	C	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	7	137080395	137080395	C	A	SNP	DGKI	ENST00000288490	human	ensembl	74_37	-1	known	silent	c.3030	p.V1010	1.000	pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom	pfam_Diacylglycerol_kin_accessory,pfam_Diacylglycerol_kinase_cat_dom,pfam_Prot_Kinase_C-like_PE/DAG-bd,pfam_Ankyrin_rpt,superfamily_Ankyrin_rpt-contain_dom,smart_Prot_Kinase_C-like_PE/DAG-bd,smart_Diacylglycerol_kinase_cat_dom,smart_Diacylglycerol_kin_accessory,smart_Ankyrin_rpt,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom	-	no_errors	DGKI	HGNC	ENSG00000157680	tier1	-	-	60	0	0.00	73	29	28.43	34	0	0.00	24	22	47.83
NRK	0	genome.wustl.edu	37	X	105153297	105153297	+	Missense_Mutation	SNP	C	C	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	X	105153297	105153297	C	T	SNP	NRK	ENST00000428173	human	ensembl	74_37	+1	known	missense	c.1667	p.A556V	0.000	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Citron,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,smart_Citron,pfscan_Prot_kinase_dom	-	no_errors	NRK	HGNC	ENSG00000123572	tier1	-	-	19	0	0.00	26	26	50.00	39	0	0.00	28	31	52.54
CASC3	0	genome.wustl.edu	37	17	38324174	38324174	+	Nonsense_Mutation	SNP	C	C	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	17	38324174	38324174	C	T	SNP	CASC3	ENST00000264645	human	ensembl	74_37	+1	known	nonsense	c.1723	p.Q575*	1.000	NULL	pfam_Btz_dom	-	no_errors	CASC3	HGNC	ENSG00000108349	tier1	-	-	79	0	0.00	49	62	55.86	59	0	0.00	41	23	35.94
SIK3	0	genome.wustl.edu	37	11	116729350	116729350	+	Missense_Mutation	SNP	G	G	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	11	116729350	116729350	G	A	SNP	SIK3	ENST00000375300	human	ensembl	74_37	-1	known	missense	c.2687	p.S896L	1.000	NULL	pfam_Prot_kinase_dom,pfam_Ser-Thr/Tyr_kinase_cat_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_UBA/transl_elong_EF1B_N_euk,pfscan_Prot_kinase_dom	-	no_errors	SIK3	HGNC	ENSG00000160584	tier1	-	-	54	0	0.00	20	14	41.18	107	0	0.00	35	7	16.67
ARID1A	0	genome.wustl.edu	37	1	27106528	27106528	+	Missense_Mutation	SNP	G	G	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	1	27106528	27106528	G	A	SNP	ARID1A	ENST00000324856	human	ensembl	74_37	+1	known	missense	c.6139	p.E2047K	1.000	pfam_DUF3518	pfam_DUF3518,pfam_ARID/BRIGHT_D-bd,superfamily_ARID/BRIGHT_D-bd,superfamily_ARM-type_fold,smart_ARID/BRIGHT_D-bd,pfscan_ARID/BRIGHT_D-bd	-	no_errors	ARID1A	HGNC	ENSG00000117713	tier1	-	-	53	0	0.00	31	20	39.22	137	0	0.00	49	34	40.96
NIN	0	genome.wustl.edu	37	14	51243731	51243731	+	Missense_Mutation	SNP	T	T	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	14	51243731	51243731	T	A	SNP	NIN	ENST00000245441	human	ensembl	74_37	-1	known	missense	c.602	p.H201L	1.000	NULL	superfamily_tR-bd_arm,pfscan_EF_hand_dom	-	no_errors	NIN	HGNC	ENSG00000100503	tier1	-	-	25	0	0.00	54	30	35.71	119	0	0.00	105	26	19.85
OR11A1	0	genome.wustl.edu	37	6	29395185	29395185	+	Silent	SNP	T	T	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	6	29395185	29395185	T	A	SNP	OR11A1	ENST00000377147	human	ensembl	74_37	-1	known	silent	c.234	p.A78	0.044	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,prints_GPCR_Rhodpsn,pfscan_GPCR_Rhodpsn_7TM	pfam_GPCR_Rhodpsn,pfam_7TM_GPCR_olfarory/Srsx,prints_GPCR_Rhodpsn,prints_Olfact_rcpt,pfscan_GPCR_Rhodpsn_7TM	-	no_errors	OR11A1	HGNC	ENSG00000204694	tier1	-	-	31	0	0.00	28	19	40.43	70	0	0.00	19	22	53.66
DPPA5	0	genome.wustl.edu	37	6	74063926	74063926	+	Missense_Mutation	SNP	C	C	G			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	6	74063926	74063926	C	G	SNP	DPPA5	ENST00000370370	human	ensembl	74_37	-1	known	missense	c.23	p.R8T	0.000	NULL	NULL	-	no_errors	DPPA5	HGNC	ENSG00000203909	tier1	-	-	86	0	0.00	59	43	42.16	66	0	0.00	57	33	36.67
PGAP1	0	genome.wustl.edu	37	2	197707533	197707533	+	Missense_Mutation	SNP	T	T	G			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	T	T	T	G	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	2	197707533	197707533	T	G	SNP	PGAP1	ENST00000354764	human	ensembl	74_37	-1	known	missense	c.2542	p.N848H	0.968	NULL	pfam_PGAP1-like	-	no_errors	PGAP1	HGNC	ENSG00000197121	tier1	-	-	41	0	0.00	105	39	27.08	116	0	0.00	106	35	24.82
ADAMTS19	0	genome.wustl.edu	37	5	129072798	129072798	+	Missense_Mutation	SNP	G	G	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	5	129072798	129072798	G	T	SNP	ADAMTS19	ENST00000274487	human	ensembl	74_37	+1	known	missense	c.3511	p.V1171L	0.999	pfam_PLAC,pfscan_PLAC	pfam_ADAM_spacer1,pfam_Thrombospondin_1_rpt,pfam_Peptidase_M12B,pfam_Peptidase_M12B_N,pfam_PLAC,pfam_Pept_M10_metallopeptidase,superfamily_Thrombospondin_1_rpt,smart_ADAM_Cys-rich,smart_Thrombospondin_1_rpt,pfscan_PLAC,pfscan_Thrombospondin_1_rpt,pfscan_Peptidase_M12B,prints_Peptidase_M12B_ADAM-TS	-	no_errors	ADAMTS19	HGNC	ENSG00000145808	tier1	-	-	21	0	0.00	6	22	78.57	90	0	0.00	33	27	45.00
GPR112	0	genome.wustl.edu	37	X	135487944	135487944	+	Silent	SNP	T	T	C			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	T	T	T	C	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	X	135487944	135487944	T	C	SNP	GPR112	ENST00000370652	human	ensembl	74_37	+1	known	silent	c.8748	p.V2916	0.998	pfam_GPCR_2_secretin-like,pfscan_GPCR_2-like	pfam_GPCR_2_secretin-like,pfam_GPS_dom,pfam_Pentaxin,superfamily_ConA-like_lec_gl_sf,smart_Pentaxin,smart_GPS_dom,pfscan_GPS_dom,pfscan_GPCR_2-like,prints_GPCR_2_secretin-like	-	no_errors	GPR112	HGNC	ENSG00000156920	tier1	-	-	49	0	0.00	65	25	27.78	67	0	0.00	73	21	22.11
ARRDC5	0	genome.wustl.edu	37	19	4891142	4891142	+	Silent	SNP	G	G	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	19	4891142	4891142	G	T	SNP	ARRDC5	ENST00000381781	human	ensembl	74_37	-1	known	silent	c.945	p.I315	0.019	pfam_Arrestin_C-like,superfamily_Ig_E-set	pfam_Arrestin-like_N,pfam_Arrestin_C-like,superfamily_Ig_E-set	-	no_errors	ARRDC5	HGNC	ENSG00000205784	tier1	-	-	47	0	0.00	72	27	27.27	87	1	1.14	96	33	25.58
KLF8	0	genome.wustl.edu	37	X	56292123	56292123	+	Missense_Mutation	SNP	C	C	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C	C	A	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	X	56292123	56292123	C	A	SNP	KLF8	ENST00000468660	human	ensembl	74_37	+1	known	missense	c.592	p.P198T	0.992	NULL	pfam_Znf_C2H2,smart_Znf_C2H2-like,pfscan_Znf_C2H2	-	no_errors	KLF8	HGNC	ENSG00000102349	tier1	-	-	17	0	0.00	47	20	29.85	12	0	0.00	28	4	12.50
FGFR1	0	genome.wustl.edu	37	8	38274849	38274849	+	Missense_Mutation	SNP	G	G	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	T	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	8	38274849	38274849	G	T	SNP	FGFR1	ENST00000425967	human	ensembl	74_37	-1	known	missense	c.1731	p.N577K	1.000	pirsf_FGF_rcpt_fam,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom	pirsf_FGF_rcpt_fam,pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,pfam_Ig_I-set,pfam_Immunoglobulin,superfamily_Kinase-like_dom,smart_Ig_sub,smart_Ig_sub2,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,prints_Ser-Thr/Tyr_kinase_cat_dom,pfscan_Prot_kinase_dom,pfscan_Ig-like_dom	-	no_errors	FGFR1	HGNC	ENSG00000077782	tier1	-	-	26	0	0.00	38	11	22.45	34	0	0.00	23	18	43.90
CCDC155	0	genome.wustl.edu	37	19	49910870	49910870	+	Missense_Mutation	SNP	G	G	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	19	49910870	49910870	G	A	SNP	CCDC155	ENST00000447857	human	ensembl	74_37	+1	known	missense	c.935	p.R312H	0.998	NULL	NULL	-	no_errors	CCDC155	HGNC	ENSG00000161609	tier1	-	-	112	0	0.00	118	56	32.18	79	0	0.00	35	13	26.53
C2orf72	0	genome.wustl.edu	37	2	231911630	231911630	+	Missense_Mutation	SNP	T	T	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	T	T	T	A	T	T	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	2	231911630	231911630	T	A	SNP	C2orf72	ENST00000373640	human	ensembl	74_37	+1	putative	missense	c.782	p.L261Q	0.873	NULL	NULL	-	no_errors	C2orf72	HGNC	ENSG00000204128	tier1	-	-	86	0	0.00	103	34	24.82	89	0	0.00	89	26	22.61
SCGB1C1	0	genome.wustl.edu	37	11	194424	194424	+	Missense_Mutation	SNP	G	G	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	11	194424	194424	G	A	SNP	SCGB1C1	ENST00000342878	human	ensembl	74_37	+1	known	missense	c.262	p.V88M	1.000	pfam_Secretoglobin,superfamily_Secretoglobin	pfam_Secretoglobin,superfamily_Secretoglobin	-	no_errors	SCGB1C1	HGNC	ENSG00000188076	tier1	-	-	101	0	0.00	75	11	12.79	96	0	0.00	57	12	17.39
LCP1	0	genome.wustl.edu	37	13	46717443	46717443	+	Silent	SNP	C	C	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	13	46717443	46717443	C	T	SNP	LCP1	ENST00000323076	human	ensembl	74_37	-1	known	silent	c.1350	p.L450	1.000	pfam_CH-domain,superfamily_CH-domain,smart_CH-domain,pfscan_CH-domain	pfam_CH-domain,pfam_EF_hand_dom,pfam_CAMSAP_CH,superfamily_CH-domain,smart_EF_hand_dom,smart_CH-domain,pfscan_CH-domain,pfscan_EF_hand_dom	-	no_errors	LCP1	HGNC	ENSG00000136167	tier1	-	-	89	0	0.00	94	29	23.58	149	0	0.00	100	39	28.06
CD2AP	0	genome.wustl.edu	37	6	47573998	47573998	+	Silent	SNP	C	C	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	6	47573998	47573998	C	T	SNP	CD2AP	ENST00000359314	human	ensembl	74_37	+1	known	silent	c.1515	p.F505	1.000	NULL	pfam_SH3_domain,pfam_SH3_2,superfamily_SH3_domain,smart_SH3_domain,pfscan_SH3_domain,prints_SH3_domain	-	no_errors	CD2AP	HGNC	ENSG00000198087	tier1	-	-	48	0	0.00	92	26	22.03	122	1	0.81	94	15	13.76
TYK2	0	genome.wustl.edu	37	19	10463610	10463610	+	Silent	SNP	G	G	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	19	10463610	10463610	G	A	SNP	TYK2	ENST00000264818	human	ensembl	74_37	-1	known	silent	c.3192	p.P1064	0.036	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,superfamily_Kinase-like_dom,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pirsf_Tyr_kinase_non-rcpt_Jak/Tyk2,pfscan_Prot_kinase_dom,prints_Ser-Thr/Tyr_kinase_cat_dom	pfam_Ser-Thr/Tyr_kinase_cat_dom,pfam_Prot_kinase_dom,superfamily_Kinase-like_dom,superfamily_FERM_central,smart_Band_41_domain,smart_SH2,smart_Ser/Thr_dual-sp_kinase_dom,smart_Tyr_kinase_cat_dom,pirsf_Tyr_kinase_non-rcpt_Jak/Tyk2,pfscan_FERM_domain,pfscan_Prot_kinase_dom,prints_Tyr_kinase_non-rcpt_Jak/Tyk2,prints_Ser-Thr/Tyr_kinase_cat_dom,prints_Tyr_kinase_non-rcpt_TYK2_N	-	no_errors	TYK2	HGNC	ENSG00000105397	tier1	-	-	54	0	0.00	12	15	55.56	48	0	0.00	12	8	40.00
SLC38A8	0	genome.wustl.edu	37	16	84063139	84063139	+	Missense_Mutation	SNP	G	G	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	16	84063139	84063139	G	A	SNP	SLC38A8	ENST00000299709	human	ensembl	74_37	-1	known	missense	c.650	p.S217F	0.998	pfam_AA_transpt_TM,pfam_Tryptophan/tyrosine_permease	pfam_AA_transpt_TM,pfam_Tryptophan/tyrosine_permease	-	no_errors	SLC38A8	HGNC	ENSG00000166558	tier1	-	-	105	0	0.00	45	33	42.31	130	0	0.00	96	39	28.89
MTMR8	0	genome.wustl.edu	37	X	63563503	63563503	+	Missense_Mutation	SNP	A	A	C			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	A	A	A	C	A	A	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	X	63563503	63563503	A	C	SNP	MTMR8	ENST00000374852	human	ensembl	74_37	-1	known	missense	c.963	p.I321M	1.000	smart_Tyr_Pase_cat	pfam_Myotubularin-like_Pase_dom,smart_Tyr_Pase_cat	-	no_errors	MTMR8	HGNC	ENSG00000102043	tier1	-	-	98	0	0.00	128	33	20.50	139	0	0.00	103	27	20.61
ARRDC5	0	genome.wustl.edu	37	19	4891074	4891074	+	Missense_Mutation	SNP	G	G	C			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	19	4891074	4891074	G	C	SNP	ARRDC5	ENST00000381781	human	ensembl	74_37	-1	known	missense	c.1013	p.P338R	0.000	superfamily_Ig_E-set	pfam_Arrestin-like_N,pfam_Arrestin_C-like,superfamily_Ig_E-set	-	no_errors	ARRDC5	HGNC	ENSG00000205784	tier1	-	-	73	0	0.00	100	62	37.80	97	0	0.00	97	33	25.38
PTPN4	0	genome.wustl.edu	37	2	120704097	120704097	+	Missense_Mutation	SNP	G	G	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	A	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	2	120704097	120704097	G	A	SNP	PTPN4	ENST00000263708	human	ensembl	74_37	+1	known	missense	c.1603	p.G535R	1.000	pfam_PDZ,superfamily_PDZ,smart_PDZ,pirsf_Tyr_Pase_non-rcpt_typ-3/4,pfscan_PDZ	pfam_Tyr_Pase_rcpt/non-rcpt,pfam_FERM_PH-like_C,pfam_FERM_central,pfam_FERM_N,pfam_PDZ,pfam_FERM-adjacent,superfamily_FERM_central,superfamily_PDZ,smart_Band_41_domain,smart_PDZ,smart_Tyr_Pase_rcpt/non-rcpt,smart_Tyr_Pase_cat,pirsf_Tyr_Pase_non-rcpt_typ-3/4,pfscan_FERM_domain,pfscan_PDZ,pfscan_Tyr/Dual-sp_Pase,pfscan_Tyr_Pase_rcpt/non-rcpt,prints_Tyr_Pase_rcpt/non-rcpt,prints_Band_41_fam,prints_Ez/rad/moesin_like	-	no_errors	PTPN4	HGNC	ENSG00000088179	tier1	-	-	53	0	0.00	76	21	21.65	82	0	0.00	73	21	22.34
HACE1	0	genome.wustl.edu	37	6	105219148	105219148	+	Missense_Mutation	SNP	C	C	G			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C	C	G	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	6	105219148	105219148	C	G	SNP	HACE1	ENST00000262903	human	ensembl	74_37	-1	known	missense	c.2131	p.E711Q	1.000	pfam_HECT,superfamily_HECT,smart_HECT,pfscan_HECT	pfam_HECT,pfam_Ankyrin_rpt,superfamily_HECT,superfamily_Ankyrin_rpt-contain_dom,smart_Ankyrin_rpt,smart_HECT,pfscan_Ankyrin_rpt,pfscan_Ankyrin_rpt-contain_dom,pfscan_HECT,prints_Ankyrin_rpt	-	no_errors	HACE1	HGNC	ENSG00000085382	tier1	-	-	56	0	0.00	100	26	20.47	151	0	0.00	112	31	21.68
MGA	0	genome.wustl.edu	37	15	41961309	41961309	+	Missense_Mutation	SNP	G	G	C			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	C	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	15	41961309	41961309	G	C	SNP	MGA	ENST00000219905	human	ensembl	74_37	+1	known	missense	c.217	p.G73R	1.000	NULL	pfam_TF_T-box,pfam_bHLH_dom,superfamily_p53-like_TF_D-bd,superfamily_bHLH_dom,smart_TF_T-box,smart_bHLH_dom,pfscan_bHLH_dom,pfscan_TF_T-box,prints_TF_T-box	-	no_errors	MGA	HGNC	ENSG00000174197	tier1	-	-	50	0	0.00	78	30	27.78	122	0	0.00	114	25	17.99
CEACAM5	0	genome.wustl.edu	37	19	42224076	42224076	+	Nonsense_Mutation	SNP	C	C	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	19	42224076	42224076	C	T	SNP	CEACAM5	ENST00000221992	human	ensembl	74_37	+1	known	nonsense	c.1720	p.Q574*	0.000	pfam_Ig_I-set,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	pfam_Ig_I-set,pfam_Ig_V-set,pfam_Immunoglobulin,smart_Ig_sub,smart_Ig_sub2,pfscan_Ig-like_dom	-	no_errors	CEACAM5	HGNC	ENSG00000105388	tier1	-	-	107	0	0.00	136	66	32.67	59	0	0.00	32	8	20.00
ABCC2	0	genome.wustl.edu	37	10	101595898	101595898	+	Silent	SNP	C	C	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C	C	T	C	C	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	10	101595898	101595898	C	T	SNP	ABCC2	ENST00000370449	human	ensembl	74_37	+1	known	silent	c.3465	p.T1155	0.997	pfam_ABC_transptr_TM_dom,superfamily_ABC1_TM_dom,pfscan_ABC1_TM_dom,tigrfam_Multidrug-R_assoc	pfam_ABC_transptr_TM_dom,pfam_ABC_transporter-like,superfamily_ABC1_TM_dom,superfamily_P-loop_NTPase,smart_AAA+_ATPase,pfscan_ABC_transporter-like,pfscan_ABC1_TM_dom,tigrfam_Multidrug-R_assoc	-	no_errors	ABCC2	HGNC	ENSG00000023839	tier1	-	-	55	0	0.00	32	44	57.89	67	0	0.00	18	41	69.49
BTBD10	0	genome.wustl.edu	37	11	13441262	13441262	+	Frame_Shift_Del	DEL	G	G	-			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G	G	-	G	G	Unknown	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	11	13441262	13441262	G	-	DEL	BTBD10	ENST00000278174	human	ensembl	74_37	-1	known	frame_shift_del	c.329	p.P110fs	1.000	NULL	superfamily_BTB/POZ_fold,smart_BTB/POZ-like	-	no_errors	BTBD10	HGNC	ENSG00000148925	tier1			38	0	0.00	14	66	82.50	48	0	0.00	5	37	88.10
DLGAP3	0	genome.wustl.edu	37	1	35351792	35351792	+	Missense_Mutation	SNP	C	C	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	1	35351792	35351792	C	T	SNP	DLGAP3	ENST00000235180	human	ensembl	74_37	-1	known	missense	c.1481	p.G494D	1.000	NULL	pfam_GKAP	-	no_errors	DLGAP3	HGNC	ENSG00000116544	tier1	-	-	42	0	0.00	14	3	17.65	9	0	0.00	9	0	0.00
FAM131C	0	genome.wustl.edu	37	1	16384813	16384813	+	R	SNP	G	G	C			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	1	16384813	16384813	G	C	SNP	FAM131C	ENST00000494078	human	ensembl	74_37	-1	known	rna	NULL	NULL	0.002	-	-	-	no_errors	FAM131C	HGNC	ENSG00000185519	tier1	-	-	124	0	0.00	51	31	37.80	5	0	0.00	0	0	0.00
IFITM3	0	genome.wustl.edu	37	11	320723	320723	+	Missense_Mutation	SNP	C	C	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	11	320723	320723	C	T	SNP	IFITM3	ENST00000399808	human	ensembl	74_37	-1	known	missense	c.91	p.V31M	0.000	NULL	pfam_CD225/Dispanin_fam	-	no_errors	IFITM3	HGNC	ENSG00000142089	tier1	rs199582787	-	63	0	0.00	42	9	17.65	10	0	0.00	8	1	11.11
LOXHD1	0	genome.wustl.edu	37	18	44146368	44146368	+	Silent	SNP	G	G	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	18	44146368	44146368	G	T	SNP	LOXHD1	ENST00000536736	human	ensembl	74_37	-1	known	silent	c.2289	p.A763	0.277	pfam_PLAT/LH2_dom,superfamily_Lipase_LipOase,smart_PLAT/LH2_dom,pfscan_PLAT/LH2_dom	pfam_PLAT/LH2_dom,superfamily_Lipase_LipOase,smart_PLAT/LH2_dom,pfscan_PLAT/LH2_dom	-	no_errors	LOXHD1	HGNC	ENSG00000167210	tier1	-	-	40	0	0.00	27	4	12.90	21	0	0.00	7	0	0.00
ANKRD20A2	0	genome.wustl.edu	37	9	42375546	42375547	+	R	INS	-	-	ACACC			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	-	-					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	9	42375546	42375547	-	ACACC	INS	ANKRD20A2	ENST00000477139	human	ensembl	74_37	+1	known	rna	NULL	NULL	0.000:0.000	-	-	-	no_errors	ANKRD20A2	HGNC	ENSG00000183148	tier1			0	0	0.00	0	0	0.00	0	0	0.00	0	0	0.00
ENSG00000221664	0	genome.wustl.edu	37	1	77857120	77857125	+	R	DEL	ATATAC	ATATAC	-			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	ATATAC	ATATAC					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	1	77857120	77857125	ATATAC	-	DEL	ENSG00000221664	ENST00000408737	human	ensembl	74_37	-1	novel	rna	NULL	NULL	0.993:0.996:0.997:0.998:0.999:0.999	-	-	-	no_errors	AC095030.1	Clone_based_ensembl_gene	ENSG00000221664	tier1			0	0	0.00	0	0	0.00	0	0	0.00	0	0	0.00
ENSG00000239012	0	genome.wustl.edu	37	1	142653747	142653747	+	R	SNP	G	G	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	1	142653747	142653747	G	T	SNP	ENSG00000239012	ENST00000459390	human	ensembl	74_37	+1	novel	rna	NULL	NULL	0.000	-	-	-	no_errors	AL583842.1	Clone_based_ensembl_gene	ENSG00000239012	tier1	-	-	235	1	0.42	414	65	13.54	0	0	0.00	0	0	0.00
HNRNPA3	0	genome.wustl.edu	37	2	178080861	178080861	+	Missense_Mutation	SNP	G	G	T			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	2	178080861	178080861	G	T	SNP	HNRNPA3	ENST00000392524	human	ensembl	74_37	+1	known	missense	c.498	p.K166N	1.000	pfam_RRM_dom,smart_RRM_dom,pfscan_RRM_dom	pfam_RRM_dom,smart_RRM_dom,pfscan_RRM_dom	-	no_errors	HNRNPA3	HGNC	ENSG00000170144	tier1	-	-	31	0	0.00	20	4	16.67	1	0	0.00	0	0	0.00
MT-ATP6	0	genome.wustl.edu	37	MT	8714	8714	+	Missense_Mutation	SNP	C	C	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	C	C					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	MT	8714	8714	C	A	SNP	MT-ATP6	ENST00000361899	human	ensembl	74_37	+1	known	missense	c.188	p.T63N	NULL	pfam_ATPase_F0-cplx_asu,superfamily_ATPase_F0-cplx_asu,tigrfam_ATPase_F0-cplx_asu	pfam_ATPase_F0-cplx_asu,superfamily_ATPase_F0-cplx_asu,prints_ATPase_F0-cplx_asu,tigrfam_ATPase_F0-cplx_asu	-	no_errors	MT-ATP6	HGNC	ENSG00000198899	tier1	-	-	46	0	0.00	9	2	18.18	4	0	0.00	0	0	0.00
WASH3P	0	genome.wustl.edu	37	15	102515340	102515340	+	R	SNP	G	G	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	15	102515340	102515340	G	A	SNP	WASH3P	ENST00000557932	human	ensembl	74_37	+1	known	rna	NULL	NULL	1.000	-	-	-	no_errors	WASH3P	HGNC	ENSG00000185596	tier1	-	-	305	0	0.00	89	68	43.31	0	0	0.00	1	0	0.00
CBWD1	0	genome.wustl.edu	37	9	122049	122049	+	Silent	SNP	G	G	A			TCGA-SI-A71Q-01A-12D-A33E-09	TCGA-SI-A71Q-10A-01D-A33H-09	G	G					Unknown	Untested	Somatic	Phase_IV	WXS	none			Illumina HiSeq	289dd857-9301-4214-8ae5-3ae1f84be485	bbc63b41-0a71-4886-9194-ffdeae6bb13f	9	122049	122049	G	A	SNP	CBWD1	ENST00000356521	human	ensembl	74_37	-1	known	silent	c.993	p.V331	1.000	pfam_Cbl_biosynth_CobW-like_C,superfamily_Cbl_biosynth_CobW-like_C	pfam_CobW/HypB/UreG_dom,pfam_Cbl_biosynth_CobW-like_C,superfamily_P-loop_NTPase,superfamily_Cbl_biosynth_CobW-like_C	-	no_errors	CBWD1	HGNC	ENSG00000172785	tier1	-	-	181	0	0.00	5	108	95.58	2	0	0.00	0	2	100.00